American Journal of Physiology-Cell Physiology

Article	Citations
Adipose tissue inflammation and metabolic dysfunction in obesity	554
Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis	245
Long-term complications of COVID-19	211
A brief history of organoids	199
Mitochondrial metabolic manipulation by SARS-CoV-2 in peripheral blood mononuclear cells of patients with COVID-19	142
Purinergic signaling, DAMPs, and inflammation	130
Exosomes derived from mmu_circ_0000250-modified adipose-derived mesenchymal stem cells promote wound healing in diabetic mice by inducing miR-128-3p/SIRT1-mediated autophagy	128
The H+-ATPase (V-ATPase): from proton pump to signaling complex in health and disease	76
Single-cell transcriptomic analysis identifies extensive heterogeneity in the cellular composition of mouse Achilles tendons	68
In vitro and ex vivo models of adipocytes	67
The kynurenine connection: how exercise shifts muscle tryptophan metabolism and affects energy homeostasis, the immune system, and the brain	66
Aquaporin-3 in the epidermis: more than skin deep	66
Extracellular matrix dynamics in vascular remodeling	64
Depletion of resident muscle stem cells negatively impacts running volume, physical function, and muscle fiber hypertrophy in response to lifelong physical activity	62
Neuroendocrine signaling in the skin with a special focus on the epidermal neuropeptides	57
Molecular nature and physiological role of the mitochondrial calcium uniporter channel	57
Wound healing and fibrosis: a contrasting role for periostin in skin and the oral mucosa	53
Extracellular vesicles as signaling mediators in type 2 diabetes mellitus	52
Neutrophil heterogeneity and fate in inflamed tissues: implications for the resolution of inflammation	50
Stem cells and lung regeneration	48
The intersection of metformin and inflammation	48
Tenascin-C in cardiac disease: a sophisticated controller of inflammation, repair, and fibrosis	47
Heterogeneity within molecular subtypes of breast cancer	46
H2S as a potential defense against COVID-19?	45
Soluble ACE2 as a potential therapy for COVID-19	42

Is REDD1 a metabolic double agent? Lessons from physiology and pathology	41
Conjunction junction, what’s the function? CCN proteins as targets in fibrosis and cancers	40
Integrative view of serpins in health and disease: the contribution of serpinA3	38
Cellular metabolomics of pulmonary fibrosis, from amino acids to lipids	37
Drivers of dynamic intratumor heterogeneity and phenotypic plasticity	37
Extracellular vesicle secretion is tissue-dependent ex vivo and skeletal muscle myofiber extracellular vesicles reach the circulation in vivo	37
Mitochondrial redox regulation and myocardial ischemia-reperfusion injury	36
Hydrogen sulfide rescues high glucose-induced migration dysfunction in HUVECs by upregulating miR-126-3p	35
Irradiation-induced senescence of bone marrow mesenchymal stem cells aggravates osteogenic differentiation dysfunction via paracrine signaling	34
Muscle-nerve communication and the molecular assessment of human skeletal muscle denervation with aging	33
The glycosaminoglycan interactome 2.0	33
Factors mediating spaceflight-induced skeletal muscle atrophy	33
Microglia depletion exacerbates acute seizures and hippocampal neuronal degeneration in mouse models of epilepsy	32
New aspects of hepatic endothelial cells in physiology and nonalcoholic fatty liver disease	31
Translating the force—mechano-sensing GPCRs	31
Cell physiology and molecular mechanism of anion transport by erythrocyte band 3/AE1	30
Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension	30
TRPV4-Rho signaling drives cytoskeletal and focal adhesion remodeling in trabecular meshwork cells	30
Aerobic exercise and resistance exercise alleviate skeletal muscle atrophy through IGF-1/IGF-1R-PI3K/Akt pathway in mice with myocardial infarction	30
Advances in aquaporin-2 trafficking mechanisms and their implications for treatment of water balance disorders	29
Mitochondria-cytokine crosstalk following skeletal muscle injury and disuse: a mini-review	29
Long noncoding RNA Kcnq1ot1 promotes sC5b-9-induced podocyte pyroptosis by inhibiting miR-486a-3p and upregulating NLRP3	29
Disuse-induced skeletal muscle atrophy in disease and nondisease states in humans: mechanisms, prevention, and recovery strategies	29
Upregulating microRNA-874-3p inhibits CXCL12 expression to promote angiogenesis and suppress inflammatory response in ischemic stroke	29
Mitochondrial DNA damage as driver of cellular outcomes	29
ARF family GTPases with links to cilia	29
LncRNA GAS5 inhibits miR-579-3p to activate SIRT1/PGC-1α/Nrf2 signaling pathway to reduce cell pyroptosis in sepsis-associated renal injury	29
The CD38 glycohydrolase and the NAD sink: implications for pathological conditions	28
More than a cell biosensor: aryl hydrocarbon receptor at the intersection of physiology and inflammation	28
TNFα and IL-17 alkalinize airway surface liquid through CFTR and pendrin	28
Heterogeneous groups of alveolar type II cells in lung homeostasis and repair	27
Role of glypican-1 in regulating multiple cellular signaling pathways	27
The role of lamina cribrosa tissue stiffness and fibrosis as fundamental biomechanical drivers of pathological glaucoma cupping	27
Thrombospondin-1 in maladaptive aging responses: a concept whose time has come	26
Breast cancer-associated skeletal muscle mitochondrial dysfunction and lipid accumulation is reversed by PPARG	26
LncRNA GAS5 attenuates fibroblast activation through inhibiting Smad3 signaling	25
Monocyte recruitment and fate specification after myocardial infarction	25
Resolution of inflammation in immune and nonimmune cells by interleukin-19	25
G protein-coupled receptor signaling: transducers and effectors	25
Engineering fiber anisotropy within natural collagen hydrogels	25
Cardiac tissue remodeling in healthy aging: the road to pathology	25
Out of breath, out of time: interactions between HIF and circadian rhythms	25
Sex omission and male bias are still widespread in cell experiments	24
The importance of mitochondrial quality control for maintaining skeletal muscle function across health span	24
GPCR systems pharmacology: a different perspective on the development of biased therapeutics	24
Macrophages in myocardial infarction	23
Sequential paracrine mechanisms are necessary for the therapeutic benefits of stem cell therapy	23
“SLC-omics” of the kidney: solute transporters along the nephron	23
Control of coronary vascular resistance by eicosanoids via a novel GPCR	23
Assessment of the effects of Syk and BTK inhibitors on GPVI-mediated platelet signaling and function	23

A glitch in the matrix: the pivotal role for extracellular matrix remodeling during muscle hypertrophy	23
Osteoclast-derived exosomal let-7a-5p targets Smad2 to promote the hypertrophic differentiation of chondrocytes	23
Characterization of cellular oxidative stress response by stoichiometric redox proteomics	23
Recent progress in assays for GPCR drug discovery	22
Coreceptor functions of cell surface heparan sulfate proteoglycans	22
Mitochondrial quality surveillance: mitophagy in cardiovascular health and disease	22
The role of the sphingolipid pathway in liver fibrosis: an emerging new potential target for novel therapies	22
miRNA degradation in the mammalian brain	22
The essential role of intraflagellar transport protein IFT81 in male mice spermiogenesis and fertility	22
Mechanisms of exercise as a preventative measure to muscle wasting	22
Burn-induced hypermetabolism and skeletal muscle dysfunction	22
Role of SERCA and sarcolipin in adaptive muscle remodeling	22
Recent advances in understanding cancer-associated fibroblasts in pancreatic cancer	22
WNKs are potassium-sensitive kinases	21
Regulatory networks coordinating mitochondrial quality control in skeletal muscle	21
The emerging role of MEIS1 in cell proliferation and differentiation	21
Diseases caused by mutations in the Na+/K+ pump α1 gene ATP1A1	21
Actin dynamics as critical ion channel regulator: ENaC and Piezo in focus	21
Electrically stimulated contractile activity-induced transcriptomic responses and metabolic remodeling in C2C12 myotubes: twitch vs. tetanic contractions	21
Mitochondrial transplantation in cardiomyocytes: foundation, methods, and outcomes	21
Mechanisms and mathematical modeling of ROS production by the mitochondrial electron transport chain	21
3-Mercaptopyruvate sulfurtransferase/hydrogen sulfide protects cerebral endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury via mitoprotection and inhibition of the RhoA/	21
Exploring mechanistic links between extracellular branched-chain amino acids and muscle insulin resistance: an in vitro approach	20
Barriers and opportunities for gemcitabine in pancreatic cancer therapy	20
Generation and optimization of highly pure motor neurons from human induced pluripotent stem cells via lentiviral delivery of transcription factors	20
The microRNA-29 family: role in metabolism and metabolic disease	20
Aquaporin water channels as regulators of cell-cell adhesion proteins	20
Knockdown of the E3 ubiquitin ligase UBR5 and its role in skeletal muscle anabolism	20
Role of oxygen in fetoplacental endothelial responses: hypoxia, physiological normoxia, or hyperoxia?	20
Let-7d-5p suppresses inflammatory response in neonatal rats with necrotizing enterocolitis via LGALS3-mediated TLR4/NF-κB signaling pathway	20
Super-relaxed state of myosin in human skeletal muscle is fiber-type dependent	19
Neuronal G protein-gated K+ channels	19
Role of metaplasia during gastric regeneration	19
Mitochondrial stress responses in Duchenne muscular dystrophy: metabolic dysfunction or adaptive reprogramming?	19
Next-generation inward rectifier potassium channel modulators: discovery and molecular pharmacology	19
LRRC8A homohexameric channels poorly recapitulate VRAC regulation and pharmacology	19
Identification and characterization of Fbxl22, a novel skeletal muscle atrophy-promoting E3 ubiquitin ligase	19
Suppression of long noncoding RNA MALAT1 inhibits the development of uveal melanoma via microRNA-608-mediated inhibition of HOXC4	19
Aquaporin-5 regulation of cell–cell adhesion proteins: an elusive “tail” story	19
Milk exosomes in nutrition and drug delivery	19
Bioprinting stem cells: building physiological tissues one cell at a time	19
Epigenetic evidence for distinct contributions of resident and acquired myonuclei during long-term exercise adaptation using timed in vivo myonuclear labeling	18
Indoxyl sulfate impairs angiogenesis via chronic aryl hydrocarbon receptor activation	18
Skeletal muscle progenitors are sensitive to collagen architectural features of fibril size and cross linking	18
Sex-specific adaptations to high-salt diet preserve electrolyte homeostasis with distinct sodium transporter profiles	18
Different modalities of host cell death and their impact onMycobacterium tuberculosisinfection	18
Coordinated alpha-crystallin B phosphorylation and desmin expression indicate adaptation and deadaptation to resistance exercise-induced loading in human skeletal muscle	18
Serum extracellular vesicle miR-203a-3p content is associated with skeletal muscle mass and protein turnover during disuse atrophy and regrowth	18
Protein biomarkers in breast cancer-derived extracellular vesicles for use in liquid biopsies	18
Nonclassical monocytes in cardiovascular physiology and disease	17
WNK3 and WNK4 exhibit opposite sensitivity with respect to cell volume and intracellular chloride concentration	17
A semiautomated measurement of muscle fiber size using the Imaris software	17
Spatiotemporal diversity and regulation of glycosaminoglycans in cell homeostasis and human disease	17
The role of phospholamban and GSK3 in regulating rodent cardiac SERCA function	17
Changes in endothelial glycocalyx layer protective ability after inflammatory stimulus	17
MicroRNA-195 regulates Tuft cell function in the intestinal epithelium by altering translation of DCLK1	17
Recent progress on surfactant protein A: cellular function in lung and kidney disease development	17
Procoagulant platelets: novel players in thromboinflammation	17
The role of Cl−and K+efflux in NLRP3 inflammasome and innate immune response activation	16
The cellular and molecular basis of in vivo synaptic plasticity in rodents	16
Oncosuppressive roles of decorin through regulation of multiple receptors and diverse signaling pathways	16
Hypoxia-inducible factor as a bridge between healthy barrier function, wound healing, and fibrosis	16
Rho GTPases and the emerging role of tunneling nanotubes in physiology and disease	16
Plasminogen activator receptor assemblies in cell signaling, innate immunity, and inflammation	16
Adaptive and maladaptive roles of lipid droplets in health and disease	16
Discovery of thymosin β4 as a human exerkine and growth factor	16
Overlapping and distinct biological effects of IL-6 classic and trans-signaling in vascular endothelial cells	16
Notch enhances Ca2+ entry by activating calcium-sensing receptors and inhibiting voltage-gated K+ channels	16
Murine models of Duchenne muscular dystrophy: is there a best model?	16
Chloride transport modulators as drug candidates	16
Global changes to HepG2 cell metabolism in response to galactose treatment	16
Advances in the development of novel compounds targeting cation-chloride cotransporter physiology	15
Proteolysis: a key post-translational modification regulating proteoglycans	15
Circulating miRNAs associated with nonalcoholic fatty liver disease	15
Immunoengineering approaches for cytokine therapy	15
Hypoxia-inducible factor-1 mediates pancreatic β-cell dysfunction by intermittent hypoxia	15
From initial segment to cauda: a regional characterization of mouse epididymal CD11c+ mononuclear phagocytes based on immune phenotype and function	15
TRPV1 activation stimulates NKCC1 and increases hydrostatic pressure in the mouse lens	15
Potassium channels in intestinal epithelial cells and their pharmacological modulation: a systematic review	15
miR-19b-3p is associated with a diametric response to resistance exercise in older adults and regulates skeletal muscle anabolism via PTEN inhibition	15

KATP channels in lymphatic function	15
Bioinspired in vitro microenvironments to control cell fate: focus on macromolecular crowding	15
The regulation of polyamine pathway proteins in models of skeletal muscle hypertrophy and atrophy: a potential role for mTORC1	14
Microfluidic confinement enhances phenotype and function of hepatocyte spheroids	14
Coordinate adaptations of skeletal muscle and kidney to maintain extracellular [K+] during K+-deficient diet	14
Role of proton-activated G protein-coupled receptors in pathophysiology	14
TRPV1 activation mitigates hypoxic injury in mouse cardiomyocytes by inducing autophagy through the AMPK signaling pathway	14
The septate junction protein Tetraspanin 2A is critical to the structure and function of Malpighian tubules inDrosophila melanogaster	14
Hyaluronan in pathophysiology of vascular diseases: specific roles in smooth muscle cells, endothelial cells, and macrophages	14
Chaperone-mediated autophagy protects cardiomyocytes against hypoxic-cell death	14
Skeletal muscle wasting: the estrogen side of sexual dimorphism	14
Recent advances in measuring and understanding the regulation of exercise-mediated protein degradation in skeletal muscle	14
Ca2+dependency of limb muscle fiber contractile mechanics in young and older adults	14
The role of mitochondria in the pathophysiology and treatment of common metabolic diseases in humans	14
CD47 and thrombospondin-1 regulation of mitochondria, metabolism, and diabetes	14
Mitochondrial ion channels in cardiac function	14
Glycosaminoglycans in cancer therapy	13
Mechanosensitive myosin II but not cofilin primarily contributes to cyclic cell stretch-induced selective disassembly of actin stress fibers	13
Inhibition of miR-155 potentially protects against lipopolysaccharide-induced acute lung injury through the IRF2BP2-NFAT1 pathway	13
Novel HIF-1-target gene isthmin1 contributes to hypoxia-induced hyperpermeability of pulmonary microvascular endothelial cells monolayers	13
lncRNAs in T lymphocytes: RNA regulation at the heart of the immune response	13
Role of platelets in regulating activated coagulation factor XI activity	13
Suppression of lncRNA HOTAIR alleviates RCC angiogenesis through regulating miR-126/EGFL7 axis	13
Aggrecan and versican: two brothers close or apart	13
ALY688 elicits adiponectin-mimetic signaling and improves insulin action in skeletal muscle cells	13
Moving human muscle physiology research forward: an evaluation of fiber type-specific protein research methodologies	13
Targeting syndecan-1: new opportunities in cancer therapy	13
Emerging roles of calcium-sensing receptor in the local regulation of intestinal transport of ions and calcium	12
Downregulation of AAA-domain-containing protein 2 restrains cancer stem cell properties in esophageal squamous cell carcinoma via blockade of the Hedgehog signaling pathway	12
Effect of luminal flow on doming of mpkCCD cells in a 3D perfusable kidney cortical collecting duct model	12
Ex vivo use of cell-permeable succinate prodrug attenuates mitochondrial dysfunction in blood cells obtained from carbon monoxide-poisoned individuals	12
Kir6.1 and SUR2B in Cantú syndrome	12
Vessel-on-a-chip models for studying microvascular physiology, transport, and function in vitro	12
MicroRNA-99b-5p downregulates protein synthesis in human primary myotubes	12
LRG1 facilitates corneal fibrotic response by inducing neutrophil chemotaxis via Stat3 signaling in alkali-burned mouse corneas	12
Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature	12
Dystrophin-negative slow-twitch soleus muscles are not susceptible to eccentric contraction induced injury over the lifespan of the mdx mouse	12
Inwardly rectifying K+ channels 4.1 and 5.1 (Kir4.1/Kir5.1) in the renal distal nephron	12
Proteoglycans in Toll-like receptor responses and innate immunity	12
Pituitary adenylate cyclase-activating polypeptide-induced PAC1 receptor internalization and recruitment of MEK/ERK signaling enhance excitability of dentate gyrus granule cells	12
The effect of young and old ex vivo human serum on cellular protein synthesis and growth in an in vitro model of aging	12
Brefeldin A and kifunensine modulate LPS-induced lung endothelial hyperpermeability in human and bovine cells	12
The β1-integrin plays a key role in LEC invasion in an optimized 3-D collagen matrix model	12
Divergent effects of genetic and pharmacological inhibition of Nox2 NADPH oxidase on insulin resistance-related vascular damage	12
Active modulation of human erythrocyte mechanics	12
The mechanobiome: a goldmine for cancer therapeutics	11
Reversing mitochondrial defects in aged hearts: role of mitochondrial calpain activation	11
Skeletal tissue regulation by catalase overexpression in mitochondria	11
The role of the tripartite synapse in the heart: how glial cells may contribute to the physiology and pathophysiology of the intracardiac nervous system	11
Nicotinamide N-methyltransferase upregulation via the mTORC1-ATF4 pathway activation contributes to palmitate-induced lipotoxicity in hepatocytes	11
Isolation and characterization of muscle stem cells, fibro-adipogenic progenitors, and macrophages from human skeletal muscle biopsies	11
Role of hepatic lipid species in the progression of nonalcoholic fatty liver disease	11
The aged extracellular matrix and the profibrotic role of senescence-associated secretory phenotype	11
Transforming nanobodies into high-precision tools for protein function analysis	11
Altered intramuscular network of lipid droplets and mitochondria in type 2 diabetes	11
Syncytialization alters the extracellular matrix and barrier function of placental trophoblasts	11
Dynamics and mechanistic underpinnings to pharmacology of class A GPCRs: an NMR perspective	11
Caveolin-1 stabilizes ATP7A, a copper transporter for extracellular SOD, in vascular tissue to maintain endothelial function	11
Impaired glucose partitioning in primary myotubes from severely obese women with type 2 diabetes	11
Cartilage extracellular matrix-derived matrikines in osteoarthritis	11
Elastin, arterial mechanics, and stenosis	11
Early functional changes associated with alpha-synuclein proteinopathy in engineered human neural networks	11
Manipulation of the miR-378a/mt-ATP6 regulatory axis rescues ATP synthase in the diabetic heart and offers a novel role for lncRNA Kcnq1ot1	11
β2 integrin activation and signal transduction in leukocyte recruitment	11
Succinylation at a key residue of FEN1 is involved in the DNA damage response to maintain genome stability	10
TRIM59 inhibits PPM1A through ubiquitination and activates TGF-β/Smad signaling to promote the invasion of ectopic endometrial stromal cells in endometriosis	10
Role of glycolysis in the development of atherosclerosis	10
Loss of the mitochondrial phosphate carrier SLC25A3 induces remodeling of the cardiac mitochondrial protein acylome	10
Pancreatic fat cells of humans with type 2 diabetes display reduced adipogenic and lipolytic activity	10
Role of mechanosensitive channels/receptors in atherosclerosis	10
Maresin-1 induces cardiomyocyte hypertrophy through IGF-1 paracrine pathway	10
Essential hypertension is associated with blunted smooth muscle cell vasodilator responsiveness and is reversed by 10-20-30 training in men	10
Premature satellite cell activation before injury accelerates myogenesis and disrupts neuromuscular junction maturation in regenerating muscle	10
Kir5.1 channels: potential role in epilepsy and seizure disorders	10
The ocular pulse decreases aqueous humor outflow resistance by stimulating nitric oxide production	10
A common genetic variant in zinc transporter ZnT2 (Thr288Ser) is present in women with low milk volume and alters lysosome function and cell energetics	10
Protective and anti-inflammatory effects of acetylcholine in the heart	10
Arterial remodeling: the role of mitochondrial metabolism in vascular smooth muscle cells	10
Loss of calpains-1 and -2 prevents repair of plasma membrane scrape injuries, but not small pores, and induces a severe muscular dystrophy	10
Effect of the ketogenic diet in excitable tissues	10
Downregulation of the Ca2+-activated K+ channel KCa3.1 in mouse preosteoblast cells treated with vitamin D receptor agonist	10
Glucose-induced, duration-dependent genome-wide DNA methylation changes in human endothelial cells	10
Is heparan sulfate a target for inhibition of RNA virus infection?	10
Myristoylated alanine-rich C kinase substrate-like protein-1 regulates epithelial sodium channel activity in renal distal convoluted tubule cells	10
Mitochondrial metabolism in macrophages	10
IL-17A contributes to skeletal muscle atrophy in lung cancer-induced cachexia via JAK2/STAT3 pathway	10
miR-135b-dependent downregulation of S100B promotes neural stem cell differentiation in a hypoxia/ischemia-induced cerebral palsy rat model	10
Skeletal muscle memory	10
Identification of variants of ISL1 gene promoter and cellular functions in isolated ventricular septal defects	10
Imaging microphysiological systems: a review	10
Exercise mitigates the Toll of muscle atrophy: a narrative review of the effects of exercise on Toll-like receptor-4 in leukocytes and skeletal muscle	10
Mechanisms of altered skeletal muscle action potentials in the R6/2 mouse model of Huntington’s disease	10
Early secretory pathway-resident Zn transporter proteins contribute to cellular sphingolipid metabolism through activation of sphingomyelin phosphodiesterase 1	10
Role of complement 3 in renin generation during the differentiation of mesenchymal stem cells to smooth muscle cells	10
Effect of rapamycin on mitochondria and lysosomes in fibroblasts from patients with mtDNA mutations	10