OOIR: Observatory of International Research

Papers

(The TQCC of Drug Development and Industrial Pharmacy is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
In vivo behavior of technetium-99m labeled ibuprofen in infection and inflamation animal models	31
Establishing virtual bioequivalence and bio-related dissolution specifications for naproxen using physiologically based pharmacokinetic modeling and in vitro biorelevant	30
Development and characterization of 3D printed ethylene vinyl acetate (EVA) as drug delivery device for the treatment of overactive bladder	28
Microneedle-assisted transdermal delivery of amlodipine besylate loaded nanoparticles	25
Preparation and evaluation of liposome with ropivacaine ion-pairing in local pain management	22
Formulation, biopharmaceutical evaluation and in-vitro screening of polyherbal phytosomes for breast cancer therapy	19
Construction of albumin-based nanoparticles utilizing paclitaxel-fatty acid prodrug that mimicking the natural fatty-acid binding process in vivo to syne	18
A QbD approach for optimizing the lyophilization parameters of cyclophosphamide monohydrate	18
Crisaborole loaded nanoemulgel for the mitigation of atopic dermatitis in mice model	18
Polymeric oral fast dissolving films of metformin: fabrication, optimization, in vitro, and in vivo evalua	18
Radioprotective effect of nanoniosome loaded by Mentha Pulegium essential oil on human peripheral blood mononuclear cells exposed to ionizing radiation	17
Improving cellular uptake and synergetic anti-tumor effects of magnolol and Brucea javanica oil through self-microemulsion	16
Ginkgolic acid as a fusion inhibitor: targeting RBD-ACE2 interaction with in silico, in vitro evidence of allosteric modulation and potent virucidal effect	15
Intranasal delivery of metal/metal oxide nanoparticles for the management of CNS-related diseases: theranostic and toxicity issues	15
Polymyxin B and silver nanoparticles: a nanotechnology-driven approach to overcome antibiotic resistance	15
Studies on ameliorative potentials of quercetin nanoparticles against imidacloprid induced subacute genotoxicity and histopathological alteration in Swiss albino mice	15
Transferrin functionalized poloxamer-chitosan nanoparticles of metformin: physicochemical characterization, in-vitro, and Ex-vivo studies	14
Potential anticancer effect of free and nanoformulated Deferasirox for breast cancer treatment: in-vitro and in-vivo evaluation	14
Use of nanoemulsion for co-delivery of silibinin and cabazitaxel for prostate cancer treatment	13
Polymorphic transformation of febuxostat after crystallization in presence of bentonite dispersion: characterization by the heat of fusion and heat of transition rule, and dissolution	13
Methylprednisolone 100 mg tablet formulation with pea protein: experimental approaches over intestinal permeability and cytotoxicity	13
Solubility-permeability interplay of hydrotropic solubilization of piroxicam	13
Mixed Pluronic/lecithin micelles formulation for oral bioavailability of candesartan cilexetil drug: in vitro characterization and in vivo	12
Assessment of Cytotoxic Effects of Quercetin Nanoemulgel on Different Skin Cancer cell lines	12
Nicotine transport across calu-3 cell monolayer: effect of nicotine salts and flavored e-liquids	12

Concurrent oral delivery of non-oncology drugs through solid self-emulsifying system for repurposing in hepatocellular carcinoma	12
Development of etoricoxib-loaded mesoporous silica nanoparticles laden gel as vehicle for transdermal delivery: optimization, ex vivo permeation, histopathology, and	12
The Future trends of Artificial Intelligence and innovative technologies in the new era of pharmaceutical sciences and Industry 4.0	11
Development of PU foam dressings loaded with extract of Plectranthus amboinicus for burn wound healing	11
Generative artificial intelligence and large language models in pharmaceutical formulation and personalized pharmacy: a review of opportunities, technical constraints, and regulatory readiness	11
Design and development of donepezil hydrochloride loaded nanostructured lipid carriers for efficient management of Alzheimer’s disease	11
Albendazole-loaded chitosan nanoparticle conjugated with hyaluronic acid for the treatment of psoriasis	11
An insight into molecular targets and nanotherapeutics for diabetic wound healing	10
Development and evaluation of a novel methotrexate-loaded electrospun patch to alleviate psoriasis plaques	10
Simple and high sample throughput LC/ESI-MS/MS method for bioequivalence study of prazosin, a drug with risk of orthostatic hypotension	10
An updated review on pharmacological aspects and nanotechnological advancements of frankincense boswellic acids	10
Enhanced intestinal permeation of novel sulpiride electrospun nanofibers: formulation, optimization, and ex vivo evaluation of drug absorption	10
Solid dispersion of alectinib HCl: preclinical evaluation for improving bioavailability and establishing an IVIVC model	10
Development and evaluation of a multifunctional natural composite microemulsion for anti-acne therapy: synergistic anti-inflammatory and antibacterial effects	10
Innovative strategies in the formulation and applications of mouth dissolving films for enhanced oral drug delivery	10
Correction	9
Effect of mango butter on the physicochemical properties of beeswax-Moringa seed oil-based oleogels for topical application	9
Stearyl amine coated liposome of rotigotine alleviates cognitive deficit in Parkinson’s disease induced mice model: modulation of oxidative stress, and motor coordination	9
Design and optimization of venlafaxine niosomes loaded thermosensitive in-situ gel for prolonging intranasal residence in depressive disorder	9
The use of nanomedicines in the healthcare systems: a policy brief	9
Visualizing fluid transport inside orally disintegrating tablets and changes in tablets using real-time X-ray radiography and X-ray computed tomography	9
Comparative study between pH, time and colonic bacterial enzyme triggered polymers for colonic delivery of coated ketoprofen multi-particulates	9
Matrix metalloproteinase enzyme responsive delivery of 5-Fluorouracil using Collagen-I peptide functionalized Dendrimer-Gold nanocarrier	9
Melting point depression for enhanced dissolution rate of eslicarbazepine acetate	9
Development and pharmacological evaluation of Evodia rutaecarpa extract-based transdermal gels: a novel approach for hypertension management	9
Budesonide-liposomes inclusion complex in thermosensitive gel alleviates DSS-induced ulcerative colitis in mice	9
Co-administration of Ayurvedic medicines Arshogrit and Jatyadi Ghrit, attenuate croton oil-induced hemorrhoids in rat model of recto-anal inflammation by modulating TNF-α and IL-1β levels	9
Development of immediate release tablet formulations of lornoxicam with hot melt extrusion-based three-dimensional printing technology	9
Construction and in vitro / in vivo evaluation of menantine hydrochloride oral liquid sustained-release drug delivery system	9
Doxorubicin-sanguinarine nanoparticles: formulation and evaluation of breast cancer cell apoptosis and cell cycle	8
pH-Responsive and liver-targeting drug delivery system for combination delivery of artesunate with arsenic trioxide prodrug against hepatocellular carcinoma	8
Investigation on the protective effect of Ganoderma Lucidum spore oil on pustular acne based on molecular dynamics simulation and experimental validation	8
Overcoming bottlenecks in drug delivery: the promise of biomolecular and artificial molecular motors	8
Silibinin solubilization: combined effect of co-solvency and inclusion complex formation	8
Study of compression effect on testosterone tablets	8
Evaluation of particle size distribution of sub-visible particles in powder injections with different packaging forms – small-sized sub-visible particles should not be ignored	8
Stability indicating HPTLC – densitometric method for estimation of vonoprazan fumarate	8
Role of novel drug delivery system in enhancing iron bioavailability and reducing gastrointestinal side effects in iron deficiency anemia	8
Borneol-modified docetaxel plus tetrandrine micelles for treatment of drug-resistant brain glioma	8
A Novel image processing technique for weighted particle size distribution assessment	8
Effect of modulation of alimentary and formulation pH on the pharmacokinetics of BCS-Class I, II, III, and IV compounds in rats following cassette dosing	8
Formulation of Morus alba extract loaded solid lipid nanoparticles: in silico , characterizations, and in vitro	8
Unveiling the mechanistic aspect of biogenic copper oxide nanoparticles harnessing Citrus pseudolimon for eradicating multi-drug-resistant gram-negative	8
Coreopsis Tinctoria flavonoids phospholipid complex: molecular dynamics simulation, preparation, characterization, and in vitro release	8
Stimuli-responsive mesoporous silica nanoparticles for brain tumor theranostics and drug targeting	7
Bioequivalence and pharmacokinetic prediction of oral marketed metformin extended-release tablets in Saudi Arabia	7
Polysaccharide-based suspensions: a novel pediatric-friendly formulation for administering furosemide through nasogastric tubes	7
Functionalized liposomes for intranasal levodopa delivery to the brain	7
A comprehensive review of green approaches to drug solubility enhancement	7
Systematic review on effectiveness of flavonoids against breast cancer: insights from in-vitro, in-vivo studies and molecular pathway studies	7

Formulation and optimisation of Ozenoxacin topical nano-emulgel including a comprehensive methodology to qualify and validate the critical parameters of an in-vitro rele	7
The preparation, characterization, and application of porous core–shell composite particles produced with laboratory-scale spray dryer	7
Statement of Retraction: Synthesis of Chemically Cross-Linked Hydroxypropyl Methyl Cellulose Hydrogels and their Application in Controlled Release of 5-Amino Salicylic Acid	7
Ionically cross-linked pH-responsive interpenetrating polysaccharide network hydrogel tablets for colon-targeted delivery of budesonide	6
Synthesis of a PVA-GO drug delivery system for sustained release of 4-methyl umbelliferon	6
Raloxifene HCl – quercetin co-amorphous system: preparation, characterization, and investigation of its behavior in phosphate buffer	6
Q1 and Q2 selection, Q3, IVRT, IVPT, pharmacokinetic and pharmacodynamic evaluation of topical generic product	6
Panaxadiol saponins-loaded gel for periodontitis therapy: anti-inflammatory and microbiota-modulating effects	6
Stability-indicating green HPLC method for fixed-dose tablets containing remogliflozin etabonate and teneligliptin: an AQbD approach	6
Quality by design (QbD)-driven formulation of sildenafil citrate microparticles using quasi-emulsion technique for pulmonary delivery: an in vitro study	6
Nanocrystal formulations of mebendazole employing quality by design and molecular level insights by atomistic simulations	6
Exploration of polymethacrylate and Hypromellose for the development of a non-sulfhydryl ACE inhibitor mucoadhesive system using Box-Behnken design: in-vitro and ex-vivo evaluation	6
Molecular dynamics and surfactant study for enhancing the formation and anti-oral cancer efficacy of D-limonene nanoemulsions	6
Correction	6
Enhanced photoprotection with rheum ribes -loaded solid lipid nanoparticles: a novel sunscreen gel formulation	6
Stability, in vitro release, and pharmacokinetic evaluation of standardized crude extracts, isolated compounds, and their nano-liposomes derived from	6
A rapid solid form risk assessment workflow for ophthalmic drug candidates	6
Targeted delivery of epirubicin to breast cancer cells using poly-aptamer DNA nanocarriers prepared by the RCA method with multiple repeats of aptamers of FOXM1 and AS1411	6
Glimepiride/hydroxypropyl-β-cyclodextrin inclusion compound: preparation, characterization, and evaluation	6
Empagliflozin containing chitosan-alginate nanoparticles in orodispersible film: preparation, characterization, pharmacokinetic evaluation and its in-vitro	6
Formulation and evaluation of an enoxaparin aqueous spray for the treatment of contusions by topical application	6
A newly developed UPLC-MS/MS method for simultaneous quantitative analysis of ajuforrestin A, ajuforrestin B, ajugamacrin and 8-O-acetylharpagide derived from Ajuga plan	5
Optimizing voriconazole-loaded thermoresponsive hydrogel: in silico tools and ex vivo studies	5
Effects of water-soluble additive on the release profile and pharmacodynamics of triptorelin loaded in PLGA microspheres	5
Green synthesis and biomedical potential of l -ascorbic acid-stabilized copper sulfide nanoparticles as antibacterial and antioxidant agents	5
Bicyclol alleviates high-fat diet-induced hepatic ER stress- and autophagy-associated non-alcoholic fatty liver disease/non-alcoholic steatohepatitis in mice	5
Development and optimization of Clitoria teratea synthesized silver nanoparticles and its application to nanogel systems for wound healing	5
Integrated stability and metabolomic investigation of new rifampicin and isoniazid co-loaded liposome against tuberculosis	5
Development of berberine-loaded PEGylated liposomes: in-vitro and ex-vivo evaluation	5
RETRACTED ARTICLE: Improvement of dissolution profile of eplerenone with solidified self-emulsifying drug delivery systems (S-SEDDS)	5
Correction	5
Formulate a concentrated highly branched poly(β-amino ester)/DNA polyplex – one step closer to application in lung cystic fibrosis disease	5
Comparison between molecular dynamics potentials for simulation of graphene-based nanomaterials for biomedical applications	5
Ultra-stabilized transethosomal gel for co-delivery of 5-fluorouracil and carvedilol: cytotoxicity and in vivo studies in skin cancer	5
Gliclazide loaded spanlastic nanovesicles: empowering bioavailability and antidiabetic efficacy	5
Intranasal Nanoemulsion-based In-Situ Gel Containing Dexlansoprazole: Formulation Development, In-Vitro and Ex-Vivo	5
Deoxycholic acid as a permeability enhancer of two antidiabetic drugs with distinctive biopharmaceutical properties through biological barriers	5
Targeted delivery of resveratrol using PEGylated PLGA nanoparticles decorated with folic acid for cancer therapy: characterization, and in vitro studies	5
Effect of roll compaction pressure on the properties of high drug-loaded piracetam granules and tablets	5
In vitro and in silico computational methods for assessing vaginal permeability	5
Protective effect of Euphorbia thymifolia and Euphorbia hirta against carbon tetrachloride-induced hepatotoxicity in Wistar rats	5
Method-dependent release kinetics of the sustained-release bolus tablets: a comparative study using daisy II incubator and continuous artificial saliva systems	5
Emerging nanotechnology-based therapies in the treatment of diabetes: recent developments and future opinion	5
Preparation and characterization of soluplus-based nanosuspension for dissolution enhancement of indomethacin using ultrasonic assisted precipitation method for formulation and Box-Behnken design for	5
Synthesis and characterization of magnetic Ag–Fe ₃ O ₄ @polymer hybrid nanocomposite systems with promising antibacterial applicat	5