OOIR: Observatory of International Research

Papers

(The TQCC of Drug Development and Industrial Pharmacy is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
In vivo behavior of technetium-99m labeled ibuprofen in infection and inflamation animal models	53
Establishing virtual bioequivalence and bio-related dissolution specifications for naproxen using physiologically based pharmacokinetic modeling and in vitro biorelevant	31
Preparation and evaluation of liposome with ropivacaine ion-pairing in local pain management	27
A QbD approach for optimizing the lyophilization parameters of cyclophosphamide monohydrate	24
Polymeric Oral Fast Dissolving Films of Metformin: Fabrication, Optimization, In Vitro and In Vivo Evaluat	21
Development and characterization of 3D printed ethylene vinyl acetate (EVA) as drug delivery device for the treatment of overactive bladder	20
Formulation, biopharmaceutical evaluation and in-vitro screening of polyherbal phytosomes for breast cancer therapy	19
Assessing the viability of carbamoylethyl pullulan-g-stearic acid based smart polymeric micelles for tumor targeting of raloxifene	16
Microneedle-assisted transdermal delivery of amlodipine besylate loaded nanoparticles	16
Potential anticancer effect of free and nanoformulated Deferasirox for breast cancer treatment: in-vitro and in-vivo evaluation	14
Synthesis of novel combinatorial drug delivery system (nCDDS) for co-delivery of 5-fluorouracil and leucovorin calcium for colon targeting and controlled drug release	14
Ginkgolic acid as a fusion inhibitor: targeting RBD-ACE2 interaction with in silico, in vitro evidence of allosteric modulation and potent virucidal effect	14
Transferrin functionalized poloxamer-chitosan nanoparticles of metformin: physicochemical characterization, in-vitro, and Ex-vivo studies	14
Studies on ameliorative potentials of quercetin nanoparticles against imidacloprid induced subacute genotoxicity and histopathological alteration in Swiss albino mice	14
Use of nanoemulsion for co-delivery of silibinin and cabazitaxel for prostate cancer treatment	13
Polymyxin B and silver nanoparticles: a nanotechnology-driven approach to overcome antibiotic resistance	13
Solubility-permeability interplay of hydrotropic solubilization of piroxicam	13
Improving cellular uptake and synergetic anti-tumor effects of magnolol and Brucea javanica oil through self-microemulsion	13
Radioprotective effect of nanoniosome loaded by Mentha Pulegium essential oil on human peripheral blood mononuclear cells exposed to ionizing radiation	13
Crisaborole loaded nanoemulgel for the mitigation of atopic dermatitis in mice model	13
Nicotine transport across calu-3 cell monolayer: effect of nicotine salts and flavored e-liquids	12
Mixed Pluronic/lecithin micelles formulation for oral bioavailability of candesartan cilexetil drug: in vitro characterization and in vivo	12
Polymorphic transformation of febuxostat after crystallization in presence of bentonite dispersion: characterization by the heat of fusion and heat of transition rule, and dissolution	12
Methylprednisolone 100 mg tablet formulation with pea protein: experimental approaches over intestinal permeability and cytotoxicity	11
Concurrent oral delivery of non-oncology drugs through solid self-emulsifying system for repurposing in hepatocellular carcinoma	11

Applications of bio-predictive dissolution tools for the development of solid oral dosage forms: current industry experience	11
Design and development of donepezil hydrochloride loaded nanostructured lipid carriers for efficient management of Alzheimer’s disease	11
The Future trends of Artificial Intelligence and innovative technologies in the new era of pharmaceutical sciences and Industry 4.0	10
Assessment of Cytotoxic Effects of Quercetin Nanoemulgel on Different Skin Cancer cell lines	10
Development of etoricoxib-loaded mesoporous silica nanoparticles laden gel as vehicle for transdermal delivery: optimization, ex vivo permeation, histopathology, and	10
Ocular delivery of sunitinib-loaded nanoparticles doped in tragacanthic acid hydrogel in treatment of diabetic retinopathy in rats	10
Development of PU foam dressings loaded with extract of Plectranthus amboinicus for burn wound healing	10
Network pharmacology prediction and molecular docking-based strategy to explore the pharmacodynamic substances and mechanism of “Mung Bean” against bacterial infection	10
Visualizing fluid transport inside orally disintegrating tablets and changes in tablets using real-time X-ray radiography and X-ray computed tomography	9
Simple and high sample throughput LC/ESI-MS/MS method for bioequivalence study of prazosin, a drug with risk of orthostatic hypotension	9
Solid dispersion of alectinib HCl: preclinical evaluation for improving bioavailability and establishing an IVIVC model	9
Innovative strategies in the formulation and applications of mouth dissolving films for enhanced oral drug delivery	9
An updated review on pharmacological aspects and nanotechnological advancements of frankincense boswellic acids	9
Co-administration of Ayurvedic medicines Arshogrit and Jatyadi Ghrit, attenuate croton oil-induced hemorrhoids in rat model of recto-anal inflammation by modulating TNF-α and IL-1β levels	9
Stearyl amine coated liposome of rotigotine alleviates cognitive deficit in Parkinson’s disease induced mice model: modulation of oxidative stress, and motor coordination	9
An insight into molecular targets and nanotherapeutics for diabetic wound healing	9
Correction	9
Budesonide-liposomes inclusion complex in thermosensitive gel alleviates DSS-induced ulcerative colitis in mice	8
Development and pharmacological evaluation of Evodia rutaecarpa extract-based transdermal gels: a novel approach for hypertension management	8
Evaluation of particle size distribution of sub-visible particles in powder injections with different packaging forms – small-sized sub-visible particles should not be ignored	8
A Novel image processing technique for weighted particle size distribution assessment	8
Comparative study between pH, time and colonic bacterial enzyme triggered polymers for colonic delivery of coated ketoprofen multi-particulates	8
The use of nanomedicines in the healthcare systems: a policy brief	8
Matrix metalloproteinase enzyme responsive delivery of 5-Fluorouracil using Collagen-I peptide functionalized Dendrimer-Gold nanocarrier	8
Construction and in vitro / in vivo evaluation of menantine hydrochloride oral liquid sustained-release drug delivery system	8
Effect of mango butter on the physicochemical properties of beeswax-Moringa seed oil-based oleogels for topical application	8
Development and evaluation of a novel methotrexate-loaded electrospun patch to alleviate psoriasis plaques	8
Enhanced intestinal permeation of novel sulpiride electrospun nanofibers: formulation, optimization, and ex vivo evaluation of drug absorption	8
pH-Responsive and liver-targeting drug delivery system for combination delivery of artesunate with arsenic trioxide prodrug against hepatocellular carcinoma	8
Coreopsis Tinctoria flavonoids phospholipid complex: molecular dynamics simulation, preparation, characterization, and in vitro release	7
Melting point depression for enhanced dissolution rate of eslicarbazepine acetate	7
Development of immediate release tablet formulations of lornoxicam with hot melt extrusion-based three-dimensional printing technology	7
Investigation on the protective effect of Ganoderma Lucidum spore oil on pustular acne based on molecular dynamics simulation and experimental validation	7
Silibinin solubilization: combined effect of co-solvency and inclusion complex formation	7
Functionalized liposomes for intranasal levodopa delivery to the brain	7
Formulation of Morus alba extract loaded solid lipid nanoparticles: in silico , characterizations, and in vitro	7
Stability indicating HPTLC – densitometric method for estimation of vonoprazan fumarate	7
Formulation and optimisation of Ozenoxacin topical nano-emulgel including a comprehensive methodology to qualify and validate the critical parameters of an in-vitro rele	7
The preparation, characterization, and application of porous core–shell composite particles produced with laboratory-scale spray dryer	7
A comprehensive review of green approaches to drug solubility enhancement	7
Borneol-modified docetaxel plus tetrandrine micelles for treatment of drug-resistant brain glioma	7
Investigating potential TRPV1 positive feedback to explain TRPV1 upregulation in airway disease states	7
Doxorubicin-sanguinarine nanoparticles: formulation and evaluation of breast cancer cell apoptosis and cell cycle	7
Design and optimization of venlafaxine niosomes loaded thermosensitive in-situ gel for prolonging intranasal residence in depressive disorder	7
Topical delivery of pluronic F127/TPGS mixed micelles-based hydrogel loaded with glycyrrhizic acid for atopic dermatitis treatment	7
Synthesis and drug loading improvements on mesoporous SBA-15 by spray drying	7
Statement of Retraction: Synthesis of Chemically Cross-Linked Hydroxypropyl Methyl Cellulose Hydrogels and their Application in Controlled Release of 5-Amino Salicylic Acid	7
Enhanced photoprotection with rheum ribes -loaded solid lipid nanoparticles: a novel sunscreen gel formulation	6
Empagliflozin containing chitosan-alginate nanoparticles in orodispersible film: preparation, characterization, pharmacokinetic evaluation and itsin-vitroanticancer activity	6
Bioequivalence and pharmacokinetic prediction of oral marketed metformin extended-release tablets in Saudi Arabia	6

Correction	6
Raloxifene HCl – quercetin co-amorphous system: preparation, characterization, and investigation of its behavior in phosphate buffer	6
Synthesis of a PVA-GO drug delivery system for sustained release of 4-methyl umbelliferon	6
Targeted delivery of epirubicin to breast cancer cells using poly-aptamer DNA nanocarriers prepared by the RCA method with multiple repeats of aptamers of FOXM1 and AS1411	6
PEGylated drug delivery systems in the pharmaceutical field: past, present and future perspective	6
Q1 and Q2 selection, Q3, IVRT, IVPT, pharmacokinetic and pharmacodynamic evaluation of topical generic product	6
A rapid solid form risk assessment workflow for ophthalmic drug candidates	6
Molecular dynamics and surfactant study for enhancing the formation and anti-oral cancer efficacy of D-limonene nanoemulsions	6
Exploration of polymethacrylate and Hypromellose for the development of a non-sulfhydryl ACE inhibitor mucoadhesive system using Box-Behnken design: in-vitro and ex-vivo evaluation	6
Quality by design (QbD)-driven formulation of sildenafil citrate microparticles using quasi-emulsion technique for pulmonary delivery: an in vitro study	6
Nanocrystal formulations of mebendazole employing quality by design and molecular level insights by atomistic simulations	6
Stability-indicating green HPLC method for fixed-dose tablets containing remogliflozin etabonate and teneligliptin: an AQbD approach	6
In vitro and in silico computational methods for assessing vaginal permeability	6
Glimepiride/hydroxypropyl-β-cyclodextrin inclusion compound: preparation, characterization, and evaluation	6
Ionically cross-linked pH-responsive interpenetrating polysaccharide network hydrogel tablets for colon-targeted delivery of budesonide	5
Effects of water-soluble additive on the release profile and pharmacodynamics of triptorelin loaded in PLGA microspheres	5
Poly(maleic anhydride-alt-1-octadecene)-based bioadhesive nanovehicles improve oral bioavailability of poor water-soluble gefitinib	5
Emerging nanotechnology-based therapies in the treatment of diabetes: recent developments and future opinion	5
Protective effect of Euphorbia thymifolia and Euphorbia hirta against carbon tetrachloride-induced hepatotoxicity in Wistar rats	5
Correction	5
Formulate a concentrated highly branched poly(β-amino ester)/DNA polyplex – one step closer to application in lung cystic fibrosis disease	5
Effect of roll compaction pressure on the properties of high drug-loaded piracetam granules and tablets	5
Targeted delivery of resveratrol using PEGylated PLGA nanoparticles decorated with folic acid for cancer therapy: characterization, and in vitro studies	5
Optimizing voriconazole-loaded thermoresponsive hydrogel: in silico tools and ex vivo studies	5
Gliclazide loaded spanlastic nanovesicles: empowering bioavailability and antidiabetic efficacy	5
Comparison between molecular dynamics potentials for simulation of graphene-based nanomaterials for biomedical applications	5
Green synthesis and biomedical potential of l -ascorbic acid-stabilized copper sulfide nanoparticles as antibacterial and antioxidant agents	5
A newly developed UPLC-MS/MS method for simultaneous quantitative analysis of ajuforrestin A, ajuforrestin B, ajugamacrin and 8-O-acetylharpagide derived from Ajuga plan	5
Preparation and characterization of soluplus-based nanosuspension for dissolution enhancement of indomethacin using ultrasonic assisted precipitation method for formulation and Box-Behnken design for	5
RETRACTED ARTICLE: Improvement of dissolution profile of eplerenone with solidified self-emulsifying drug delivery systems (S-SEDDS)	5