OOIR: Observatory of International Research

Papers

(The TQCC of Drug Development and Industrial Pharmacy is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Polymeric oral fast dissolving films of metformin: fabrication, optimization, in vitro, and in vivo evalua	31
In vivo behavior of technetium-99m labeled ibuprofen in infection and inflamation animal models	31
A QbD approach for optimizing the lyophilization parameters of cyclophosphamide monohydrate	30
Construction of albumin-based nanoparticles utilizing paclitaxel-fatty acid prodrug that mimicking the natural fatty-acid binding process in vivo to syne	28
Development and characterization of 3D printed ethylene vinyl acetate (EVA) as drug delivery device for the treatment of overactive bladder	23
Formulation, biopharmaceutical evaluation and in-vitro screening of polyherbal phytosomes for breast cancer therapy	21
Radioprotective effect of nanoniosome loaded by Mentha Pulegium essential oil on human peripheral blood mononuclear cells exposed to ionizing radiation	20
Establishing virtual bioequivalence and bio-related dissolution specifications for naproxen using physiologically based pharmacokinetic modeling and in vitro biorelevant	20
Ginkgolic acid as a fusion inhibitor: targeting RBD-ACE2 interaction with in silico, in vitro evidence of allosteric modulation and potent virucidal effect	19
Studies on ameliorative potentials of quercetin nanoparticles against imidacloprid induced subacute genotoxicity and histopathological alteration in Swiss albino mice	19
Intranasal delivery of metal/metal oxide nanoparticles for the management of CNS-related diseases: theranostic and toxicity issues	19
Potential anticancer effect of free and nanoformulated Deferasirox for breast cancer treatment: in-vitro and in-vivo evaluation	17
Polymyxin B and silver nanoparticles: a nanotechnology-driven approach to overcome antibiotic resistance	17
Crisaborole loaded nanoemulgel for the mitigation of atopic dermatitis in mice model	16
Use of nanoemulsion for co-delivery of silibinin and cabazitaxel for prostate cancer treatment	16
Improving cellular uptake and synergetic anti-tumor effects of magnolol and Brucea javanica oil through self-microemulsion	15
Transferrin functionalized poloxamer-chitosan nanoparticles of metformin: physicochemical characterization, in-vitro, and Ex-vivo studies	14
Methylprednisolone 100 mg tablet formulation with pea protein: experimental approaches over intestinal permeability and cytotoxicity	14
Polymorphic transformation of febuxostat after crystallization in presence of bentonite dispersion: characterization by the heat of fusion and heat of transition rule, and dissolution	14
Generative artificial intelligence and large language models in pharmaceutical formulation and personalized pharmacy: a review of opportunities, technical constraints, and regulatory readiness	14
Safety, Tolerability, and Pharmacokinetics of Oral FM888 in Healthy Chinese Adults: A Phase I, Randomized, Double-Blind, Placebo-Controlled Study	14
Mixed Pluronic/lecithin micelles formulation for oral bioavailability of candesartan cilexetil drug: in vitro characterization and in vivo	13
Nicotine transport across calu-3 cell monolayer: effect of nicotine salts and flavored e-liquids	13
Concurrent oral delivery of non-oncology drugs through solid self-emulsifying system for repurposing in hepatocellular carcinoma	13
Solubility-permeability interplay of hydrotropic solubilization of piroxicam	13

Design and development of donepezil hydrochloride loaded nanostructured lipid carriers for efficient management of Alzheimer’s disease	12
Albendazole-loaded chitosan nanoparticle conjugated with hyaluronic acid for the treatment of psoriasis	12
Development and evaluation of a multifunctional natural composite microemulsion for anti-acne therapy: synergistic anti-inflammatory and antibacterial effects	12
Development of PU foam dressings loaded with extract of Plectranthus amboinicus for burn wound healing	12
Assessment of Cytotoxic Effects of Quercetin Nanoemulgel on Different Skin Cancer cell lines	12
Simple and high sample throughput LC/ESI-MS/MS method for bioequivalence study of prazosin, a drug with risk of orthostatic hypotension	11
Development of etoricoxib-loaded mesoporous silica nanoparticles laden gel as vehicle for transdermal delivery: optimization, ex vivo permeation, histopathology, and	11
An insight into molecular targets and nanotherapeutics for diabetic wound healing	11
The Future trends of Artificial Intelligence and innovative technologies in the new era of pharmaceutical sciences and Industry 4.0	11
An updated review on pharmacological aspects and nanotechnological advancements of frankincense boswellic acids	11
An in vivo study on extended-release formulation of buprenorphine in Sprague–Dawley rats	11
Stearyl amine coated liposome of rotigotine alleviates cognitive deficit in Parkinson’s disease induced mice model: modulation of oxidative stress, and motor coordination	10
Budesonide-liposomes inclusion complex in thermosensitive gel alleviates DSS-induced ulcerative colitis in mice	10
Development and pharmacological evaluation of Evodia rutaecarpa extract-based transdermal gels: a novel approach for hypertension management	10
Enhanced intestinal permeation of novel sulpiride electrospun nanofibers: formulation, optimization, and ex vivo evaluation of drug absorption	10
Innovative strategies in the formulation and applications of mouth dissolving films for enhanced oral drug delivery	10
Solid dispersion of alectinib HCl: preclinical evaluation for improving bioavailability and establishing an IVIVC model	10
Comparative study between pH, time and colonic bacterial enzyme triggered polymers for colonic delivery of coated ketoprofen multi-particulates	10
Correction	10
Effect of mango butter on the physicochemical properties of beeswax-Moringa seed oil-based oleogels for topical application	9
Construction and in vitro / in vivo evaluation of menantine hydrochloride oral liquid sustained-release drug delivery system	9
Evaluation of particle size distribution of sub-visible particles in powder injections with different packaging forms – small-sized sub-visible particles should not be ignored	9
Improvement of aqueous solubility and oral bioavailability of luteolin: a nanosuspension approach	9
Co-administration of Ayurvedic medicines Arshogrit and Jatyadi Ghrit, attenuate croton oil-induced hemorrhoids in rat model of recto-anal inflammation by modulating TNF-α and IL-1β levels	9
The use of nanomedicines in the healthcare systems: a policy brief	9
Mitigating chemical degradation in amorphous and lipid-based formulations through cyclodextrin complexation and nanosizing	9
Study of compression effect on testosterone tablets	9
pH-Responsive and liver-targeting drug delivery system for combination delivery of artesunate with arsenic trioxide prodrug against hepatocellular carcinoma	9
Development and evaluation of a novel methotrexate-loaded electrospun patch to alleviate psoriasis plaques	9
Design and optimization of venlafaxine niosomes loaded thermosensitive in-situ gel for prolonging intranasal residence in depressive disorder	9
Formulation of Morus alba extract loaded solid lipid nanoparticles: in silico , characterizations, and in vitro	9
Effect of modulation of alimentary and formulation pH on the pharmacokinetics of BCS-Class I, II, III, and IV compounds in rats following cassette dosing	9
A Novel image processing technique for weighted particle size distribution assessment	9
Borneol-modified docetaxel plus tetrandrine micelles for treatment of drug-resistant brain glioma	8
Investigation on the protective effect of Ganoderma Lucidum spore oil on pustular acne based on molecular dynamics simulation and experimental validation	8
Systematic review on effectiveness of flavonoids against breast cancer: insights from in-vitro, in-vivo studies and molecular pathway studies	8
A comprehensive review of green approaches to drug solubility enhancement	8
Extraction, development, and ex-vivo evaluation of thermoresponsive mucoadhesive in-situ nasal gel incorpo	8
Doxorubicin-sanguinarine nanoparticles: formulation and evaluation of breast cancer cell apoptosis and cell cycle	8
Next-generation drug delivery for age-related macular degeneration: promise of controlled release formulations	8
Orodispersible tablets in psychiatric and mood disorder management: clinical value, pharmacokinetics, and patient-centric formulation strategies	8
Polysaccharide-based suspensions: a novel pediatric-friendly formulation for administering furosemide through nasogastric tubes	8
Development of immediate release tablet formulations of lornoxicam with hot melt extrusion-based three-dimensional printing technology	8
Melting point depression for enhanced dissolution rate of eslicarbazepine acetate	8
The preparation, characterization, and application of porous core–shell composite particles produced with laboratory-scale spray dryer	8
Formulation and optimisation of Ozenoxacin topical nano-emulgel including a comprehensive methodology to qualify and validate the critical parameters of an in-vitro rele	8
Role of novel drug delivery system in enhancing iron bioavailability and reducing gastrointestinal side effects in iron deficiency anemia	8
Functionalized liposomes for intranasal levodopa delivery to the brain	8
Stability indicating HPTLC – densitometric method for estimation of vonoprazan fumarate	8
Harnessing the potential of spider silk proteins as emerging biomaterials for drug delivery: classification, comparative evaluation, and future perspectives	8

Overcoming bottlenecks in drug delivery: the promise of biomolecular and artificial molecular motors	8
Silibinin solubilization: combined effect of co-solvency and inclusion complex formation	7
Statement of Retraction: Synthesis of Chemically Cross-Linked Hydroxypropyl Methyl Cellulose Hydrogels and their Application in Controlled Release of 5-Amino Salicylic Acid	7
Quality by design (QbD)-driven formulation of sildenafil citrate microparticles using quasi-emulsion technique for pulmonary delivery: an in vitro study	7
Coreopsis Tinctoria flavonoids phospholipid complex: molecular dynamics simulation, preparation, characterization, and in vitro release	7
Unveiling the mechanistic aspect of biogenic copper oxide nanoparticles harnessing Citrus pseudolimon for eradicating multi-drug-resistant gram-negative	7
Correction	7
Formulation and evaluation of an enoxaparin aqueous spray for the treatment of contusions by topical application	7
Stimuli-responsive mesoporous silica nanoparticles for brain tumor theranostics and drug targeting	7
Bioequivalence and pharmacokinetic prediction of oral marketed metformin extended-release tablets in Saudi Arabia	7
Exploration of polymethacrylate and Hypromellose for the development of a non-sulfhydryl ACE inhibitor mucoadhesive system using Box-Behnken design: in-vitro and ex-vivo evaluation	7
Targeted delivery of epirubicin to breast cancer cells using poly-aptamer DNA nanocarriers prepared by the RCA method with multiple repeats of aptamers of FOXM1 and AS1411	7
Effects of water-soluble additive on the release profile and pharmacodynamics of triptorelin loaded in PLGA microspheres	6
Enhanced photoprotection with rheum ribes -loaded solid lipid nanoparticles: a novel sunscreen gel formulation	6
Q1 and Q2 selection, Q3, IVRT, IVPT, pharmacokinetic and pharmacodynamic evaluation of topical generic product	6
A rapid solid form risk assessment workflow for ophthalmic drug candidates	6
Rutin-enabled improved systemic exposure of doxorubicin via nanostructured lipid carriers: a proof of concept through novel LC-MS/MS analysis	6
Preparation and characterization of pre-nanoemulsions encapsulating multiple oil-soluble active substances	6
Ionically cross-linked pH-responsive interpenetrating polysaccharide network hydrogel tablets for colon-targeted delivery of budesonide	6
RETRACTED ARTICLE: Improvement of dissolution profile of eplerenone with solidified self-emulsifying drug delivery systems (S-SEDDS)	6
Glimepiride/hydroxypropyl-β-cyclodextrin inclusion compound: preparation, characterization, and evaluation	6
Stability, in vitro release, and pharmacokinetic evaluation of standardized crude extracts, isolated compounds, and their nano-liposomes derived from	6
Pregabalin-loaded transferosomal gel for enhanced topical delivery in peripheral neuropathy: formulation, in vitro and ex vivo	6
In vitro and in silico computational methods for assessing vaginal permeability	6
Comparison between molecular dynamics potentials for simulation of graphene-based nanomaterials for biomedical applications	6
Development of a transdermal sumatriptan formulation with iontophoresis	6
Formulate a concentrated highly branched poly(β-amino ester)/DNA polyplex – one step closer to application in lung cystic fibrosis disease	6
Nanocrystal formulations of mebendazole employing quality by design and molecular level insights by atomistic simulations	6
Stability-indicating green HPLC method for fixed-dose tablets containing remogliflozin etabonate and teneligliptin: an AQbD approach	6
Synthesis of a PVA-GO drug delivery system for sustained release of 4-methyl umbelliferon	6
Panaxadiol saponins-loaded gel for periodontitis therapy: anti-inflammatory and microbiota-modulating effects	6
Molecular dynamics and surfactant study for enhancing the formation and anti-oral cancer efficacy of D-limonene nanoemulsions	6
Stimuli-responsive solid lipid nanoparticles for targeted drug delivery in biofilm-resistant infections: advances and challenges	6
Green synthesis and biomedical potential of l -ascorbic acid-stabilized copper sulfide nanoparticles as antibacterial and antioxidant agents	6
Novel elastic nanovesicular hydrogel system: advancing metronidazole delivery for effective periodontitis management	5
Development and validation of HPLC method for simultaneous determination of Leflunomide and folic acid in the nanoparticulate system by reversed-phase HPLC	5
Development and optimization of Clitoria teratea synthesized silver nanoparticles and its application to nanogel systems for wound healing	5
Emerging nanotechnology-based therapies in the treatment of diabetes: recent developments and future opinion	5
Synthesis and characterization of magnetic Ag–Fe ₃ O ₄ @polymer hybrid nanocomposite systems with promising antibacterial applicat	5
Correction	5
Ultra-stabilized transethosomal gel for co-delivery of 5-fluorouracil and carvedilol: cytotoxicity and in vivo studies in skin cancer	5
Optimizing voriconazole-loaded thermoresponsive hydrogel: in silico tools and ex vivo studies	5
Emerging trends and future directions in co-amorphous solid dispersions for BCS class II and IV drugs	5
Retraction: Bioactive injectable triple acting thermosensitive hydrogel enriched with nano-hydroxyapatite for bone regeneration: in-vitro characterization, Saos-2 cell line cell viability and osteogen	5
Intranasal nanoemulsion-based in-situ gel containing dexlansoprazole: formulation development, in-vitro an	5
Preparation and characterization of soluplus-based nanosuspension for dissolution enhancement of indomethacin using ultrasonic assisted precipitation method for formulation and Box-Behnken design for	5
Targeted delivery of resveratrol using PEGylated PLGA nanoparticles decorated with folic acid for cancer therapy: characterization, and in vitro studies	5
Pharmacokinetic and dissolution profiling of tadalafil formulated with SNEDDS and β-cyclodextrin in fast-dissolving tablets	5
Protective effect of Euphorbia thymifolia and Euphorbia hirta against carbon tetrachloride-induced hepatotoxicity in Wistar rats	5
Effect of roll compaction pressure on the properties of high drug-loaded piracetam granules and tablets	5
Deoxycholic acid as a permeability enhancer of two antidiabetic drugs with distinctive biopharmaceutical properties through biological barriers	5
Amelioration of tableting properties and dissolution rate of naproxen co-grinded with nicotinamide: preparation and characterization of co-grinded mixture	5
Integrated stability and metabolomic investigation of new rifampicin and isoniazid co-loaded liposome against tuberculosis	5
Gliclazide loaded spanlastic nanovesicles: empowering bioavailability and antidiabetic efficacy	5
Leveraging bile acid transporters for enhanced liver targeting and anti-alcoholic efficacy of tectoridin via liposomal delivery	5
A newly developed UPLC-MS/MS method for simultaneous quantitative analysis of ajuforrestin A, ajuforrestin B, ajugamacrin and 8-O-acetylharpagide derived from Ajuga plan	5
Development of berberine-loaded PEGylated liposomes: in-vitro and ex-vivo evaluation	5
Method-dependent release kinetics of the sustained-release bolus tablets: a comparative study using daisy II incubator and continuous artificial saliva systems	5