OOIR: Observatory of International Research

Papers

(The TQCC of Drug Development and Industrial Pharmacy is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
In vivo behavior of technetium-99m labeled ibuprofen in infection and inflamation animal models	67
Preparation and evaluation of liposome with ropivacaine ion-pairing in local pain management	63
Development and characterization of 3D printed ethylene vinyl acetate (EVA) as drug delivery device for the treatment of overactive bladder	50
Formulation, biopharmaceutical evaluation and in-vitro screening of polyherbal phytosomes for breast cancer therapy	34
A QbD approach for optimizing the lyophilization parameters of cyclophosphamide monohydrate	28
Establishing virtual bioequivalence and bio-related dissolution specifications for naproxen using physiologically based pharmacokinetic modeling and in vitro biorelevant	23
Microneedle-assisted transdermal delivery of amlodipine besylate loaded nanoparticles	23
Studies on ameliorative potentials of quercetin nanoparticles against imidacloprid induced subacute genotoxicity and histopathological alteration in Swiss albino mice	22
Polymeric implants with drug-releasing capabilities: a mapping review of laboratory research	22
Assessing the viability of carbamoylethyl pullulan-g-stearic acid based smart polymeric micelles for tumor targeting of raloxifene	18
Crystal engineering of valproic acid and carbamazepine to improve hygroscopicity and dissolution profile	17
Polycaprolactone and polycaprolactone triol blends to obtain a stable liquid nanotechnological formulation: synthesis, characterization and in vitro – in vivo taste masking evaluation	17
Improving cellular uptake and synergetic anti-tumor effects of magnolol and Brucea javanica oil through self-microemulsion	17
Synthesis of novel combinatorial drug delivery system (nCDDS) for co-delivery of 5-fluorouracil and leucovorin calcium for colon targeting and controlled drug release	16
Potential anticancer effect of free and nanoformulated Deferasirox for breast cancer treatment: in-vitro and in-vivo evaluation	15
Radioprotective effect of nanoniosome loaded by Mentha Pulegium essential oil on human peripheral blood mononuclear cells exposed to ionizing radiation	15
Solubility-permeability interplay of hydrotropic solubilization of piroxicam	13
Crisaborole loaded nanoemulgel for the mitigation of atopic dermatitis in mice model	13
Development of PU foam dressings loaded with extract of Plectranthus amboinicus for burn wound healing	13
Transferrin functionalized poloxamer-chitosan nanoparticles of metformin: physicochemical characterization, in-vitro, and Ex-vivo studies	13
Development of etoricoxib-loaded mesoporous silica nanoparticles laden gel as vehicle for transdermal delivery: optimization, ex vivo permeation, histopathology, and	12
An overview of COVID-19 aerosol box for preventing droplet and aerosol contaminations in healthcare providers performing airway intubation	12
Applications of bio-predictive dissolution tools for the development of solid oral dosage forms: current industry experience	12
Mixed Pluronic/lecithin micelles formulation for oral bioavailability of candesartan cilexetil drug: in vitro characterization and in vivo	12
Methylprednisolone 100 mg tablet formulation with pea protein: experimental approaches over intestinal permeability and cytotoxicity	12

Nicotine transport across calu-3 cell monolayer: effect of nicotine salts and flavored e-liquids	11
Network pharmacology prediction and molecular docking-based strategy to explore the pharmacodynamic substances and mechanism of “Mung Bean” against bacterial infection	11
Assessment of Cytotoxic Effects of Quercetin Nanoemulgel on Different Skin Cancer cell lines	11
Polymorphic transformation of febuxostat after crystallization in presence of bentonite dispersion: characterization by the heat of fusion and heat of transition rule, and dissolution	11
Concurrent oral delivery of non-oncology drugs through solid self-emulsifying system for repurposing in hepatocellular carcinoma	11
Aloe vera and artemisia vulgaris hydrogels: exploring the toxic effects of structural transformation of the biocompatible materials	11
Co-administration of Ayurvedic medicines Arshogrit and Jatyadi Ghrit, attenuate croton oil-induced hemorrhoids in rat model of recto-anal inflammation by modulating TNF-α and IL-1β levels	10
Design and development of donepezil hydrochloride loaded nanostructured lipid carriers for efficient management of Alzheimer’s disease	10
Visualizing fluid transport inside orally disintegrating tablets and changes in tablets using real-time X-ray radiography and X-ray computed tomography	10
Ocular delivery of sunitinib-loaded nanoparticles doped in tragacanthic acid hydrogel in treatment of diabetic retinopathy in rats	10
Solid dispersion of alectinib HCl: preclinical evaluation for improving bioavailability and establishing an IVIVC model	10
Correction	10
The use of nanomedicines in the healthcare systems: a policy brief	9
Enhanced intestinal permeation of novel sulpiride electrospun nanofibers: formulation, optimization, and ex vivo evaluation of drug absorption	9
Simple and high sample throughput LC/ESI-MS/MS method for bioequivalence study of prazosin, a drug with risk of orthostatic hypotension	9
Comparative study between pH, time and colonic bacterial enzyme triggered polymers for colonic delivery of coated ketoprofen multi-particulates	9
Stearyl amine coated liposome of rotigotine alleviates cognitive deficit in Parkinson’s disease induced mice model: modulation of oxidative stress, and motor coordination	9
An insight into molecular targets and nanotherapeutics for diabetic wound healing	9
Innovative strategies in the formulation and applications of mouth dissolving films for enhanced oral drug delivery	9
Development and evaluation of a novel methotrexate-loaded electrospun patch to alleviate psoriasis plaques	9
Budesonide-liposomes inclusion complex in thermosensitive gel alleviates DSS-induced ulcerative colitis in mice	9
Effect of mango butter on the physicochemical properties of beeswax-Moringa seed oil-based oleogels for topical application	9
Matrix metalloproteinase enzyme responsive delivery of 5-Fluorouracil using Collagen-I peptide functionalized Dendrimer-Gold nanocarrier	8
pH-Responsive and liver-targeting drug delivery system for combination delivery of artesunate with arsenic trioxide prodrug against hepatocellular carcinoma	8
Lippia graveolensHBK oleoresins, extracted by supercritical fluids, showed bactericidal activity against multidrug resistanceEnterococcus faecalisandStaphylococcus aureusstrains	8
Evaluation of particle size distribution of sub-visible particles in powder injections with different packaging forms – small-sized sub-visible particles should not be ignored	8
Construction and in vitro / in vivo evaluation of menantine hydrochloride oral liquid sustained-release drug delivery system	8
Formulation of Morus alba extract loaded solid lipid nanoparticles: in silico , characterizations, and in vitro	8
Physico-chemical properties of two anhydrous azathioprine forms and their interaction with typical pharmaceutical excipients: highlighting new findings in drug formulation development	8
Multi-directionally evaluating the formation mechanism of 1,4-dihydropyridine drug nanosuspensions through experimental validation and computer-aided drug design	8
Doxorubicin-sanguinarine nanoparticles: formulation and evaluation of breast cancer cell apoptosis and cell cycle	8
The preparation, characterization, and application of porous core–shell composite particles produced with laboratory-scale spray dryer	7
Investigating potential TRPV1 positive feedback to explain TRPV1 upregulation in airway disease states	7
A Novel image processing technique for weighted particle size distribution assessment	7
Development of immediate release tablet formulations of lornoxicam with hot melt extrusion-based three-dimensional printing technology	7
Formulation and optimisation of Ozenoxacin topical nano-emulgel including a comprehensive methodology to qualify and validate the critical parameters of an in-vitro rele	7
A comprehensive review of green approaches to drug solubility enhancement	7
Melting point depression for enhanced dissolution rate of eslicarbazepine acetate	7
Stability indicating HPTLC – densitometric method for estimation of vonoprazan fumarate	7
Topical delivery of pluronic F127/TPGS mixed micelles-based hydrogel loaded with glycyrrhizic acid for atopic dermatitis treatment	7
Functionalized liposomes for intranasal levodopa delivery to the brain	7
Investigation on the Protective Effect of Ganoderma Lucidum Spore Oil on Pustular Acne Based on Molecular Dynamics Simulation and Experimental Validation	7
Development of bifunctional vaginal suppositories by joint use terconazole and probiotic for treatment and prophylaxis of vulvovaginal candidiasis	7
Design and optimization of venlafaxine niosomes loaded thermosensitive in-situ gel for prolonging intranasal residence in depressive disorder	7
Effects of different air change rates on cleanroom ‘in operation’ status	7
Formulation design and optimization of cationic-charged liposomes of brimonidine tartrate for effective ocular drug delivery by design of experiment (DoE) approach	7
Targeted delivery of epirubicin to breast cancer cells using poly-aptamer DNA nanocarriers prepared by the RCA method with multiple repeats of aptamers of FOXM1 and AS1411	6
Q1 and Q2 selection, Q3, IVRT, IVPT, pharmacokinetic and pharmacodynamic evaluation of topical generic product	6
Quality by design (QbD)-driven formulation of sildenafil citrate microparticles using quasi-emulsion technique for pulmonary delivery: an in vitro study	6
In vitro and in silico computational methods for assessing vaginal permeability	6

Enhanced photoprotection with rheum ribes -loaded solid lipid nanoparticles: a novel sunscreen gel formulation	6
Borneol-modified docetaxel plus tetrandrine micelles for treatment of drug-resistant brain glioma	6
Synthesis of a PVA-GO drug delivery system for sustained release of 4-methyl umbelliferon	6
Development and optimization of tibezonium iodide and lignocaine hydrochloride containing novel mucoadhesive buccal tablets: a pharmacokinetic investigation among healthy humans	6
Silibinin solubilization: combined effect of co-solvency and inclusion complex formation	6
Raloxifene HCl – quercetin co-amorphous system: preparation, characterization, and investigation of its behavior in phosphate buffer	6
Comparison between molecular dynamics potentials for simulation of graphene-based nanomaterials for biomedical applications	6
Nanocrystal formulations of mebendazole employing quality by design and molecular level insights by atomistic simulations	6
Coreopsis Tinctoria flavonoids phospholipid complex: molecular dynamics simulation, preparation, characterization, and in vitro release	6
Stability-indicating green HPLC method for fixed-dose tablets containing remogliflozin etabonate and teneligliptin: an AQbD approach	6
Exploration of polymethacrylate and Hypromellose for the development of a non-sulfhydryl ACE inhibitor mucoadhesive system using Box-Behnken design: in-vitro and ex-vivo evaluation	6
PEGylated drug delivery systems in the pharmaceutical field: past, present and future perspective	6
Molecular dynamics and surfactant study for enhancing the formation and anti-oral cancer efficacy of D-limonene nanoemulsions	6
Statement of Retraction: Synthesis of Chemically Cross-Linked Hydroxypropyl Methyl Cellulose Hydrogels and their Application in Controlled Release of 5-Amino Salicylic Acid	6
A rapid solid form risk assessment workflow for ophthalmic drug candidates	6
Synthesis and drug loading improvements on mesoporous SBA-15 by spray drying	6
Empagliflozin containing chitosan-alginate nanoparticles in orodispersible film: preparation, characterization, pharmacokinetic evaluation and itsin-vitroanticancer activity	6
Effect of roll compaction pressure on the properties of high drug-loaded piracetam granules and tablets	5
Correction	5
Glimepiride/hydroxypropyl-β-cyclodextrin inclusion compound: preparation, characterization, and evaluation	5
A newly developed UPLC-MS/MS method for simultaneous quantitative analysis of ajuforrestin A, ajuforrestin B, ajugamacrin and 8-O-acetylharpagide derived from Ajuga plan	5
Preparation and characterization of soluplus-based nanosuspension for dissolution enhancement of indomethacin using ultrasonic assisted precipitation method for formulation and Box-Behnken design for	5
Improving gallic acid and quercetin bioavailability by polymeric nanoparticle formulation	5
Synthesis and characterization of magnetic Ag–Fe ₃ O ₄ @polymer hybrid nanocomposite systems with promising antibacterial applicat	5
Smart UV-spectrophotometric platforms for rapid green analysis of miconazole nitrate and nystatin in their combined suppositories and in vitro dissolution testing	5
Improvement of dissolution profile of eplerenone with solidified self-emulsifying drug delivery systems (S-SEDDS)	5
Effects of synthesis conditions and release medium pH on release properties of acyclovir – mercaptopropyl modified silica composite	5
Effects of water-soluble additive on the release profile and pharmacodynamics of triptorelin loaded in PLGA microspheres	5
Gliclazide loaded spanlastic nanovesicles: empowering bioavailability and antidiabetic efficacy	5
Amelioration of tableting properties and dissolution rate of naproxen co-grinded with nicotinamide: preparation and characterization of co-grinded mixture	5
Exposure to potentially harmful excipients in medications among neonates at a state hospital in Malaysia	5
Development and optimization of Clitoria teratea synthesized silver nanoparticles and its application to nanogel systems for wound healing	5
Retraction: Bioactive injectable triple acting thermosensitive hydrogel enriched with nano-hydroxyapatite for bone regeneration: in-vitro characterization, Saos-2 cell line cell viability and osteogen	5
Green synthesis and biomedical potential of l -ascorbic acid-stabilized copper sulfide nanoparticles as antibacterial and antioxidant agents	5
Poly(maleic anhydride-alt-1-octadecene)-based bioadhesive nanovehicles improve oral bioavailability of poor water-soluble gefitinib	5
Protective effect of Euphorbia thymifolia and Euphorbia hirta against carbon tetrachloride-induced hepatotoxicity in Wistar rats	5
Formulate a concentrated highly branched poly(β-amino ester)/DNA polyplex – one step closer to application in lung cystic fibrosis disease	5
Development of a novel human stratum corneum mimetic phospholipid vesicle-based permeation assay models for in vitro permeation studies	5
Bicyclol alleviates high-fat diet-induced hepatic ER stress- and autophagy-associated non-alcoholic fatty liver disease/non-alcoholic steatohepatitis in mice	5
Optimizing voriconazole-loaded thermoresponsive hydrogel: in silico tools and ex vivo studies	5