OOIR: Observatory of International Research

Papers

(The TQCC of Drug Development and Industrial Pharmacy is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Starch flow behavior alone and under different glidants action using the shear cell method	55
Statement of Retraction: Synthesis of Chemically Cross-Linked Hydroxypropyl Methyl Cellulose Hydrogels and their Application in Controlled Release of 5-Amino Salicylic Acid	47
Topical NSAIDs for acute local pain relief: in vitro characterization of drug delivery profiles into and through human skin	46
Enhancing flowability of fine cohesive active pharmaceutical ingredients	41
In vivo behavior of technetium-99m labeled ibuprofen in infection and inflamation animal models	26
Preparation and evaluation of sublingual film of ketorolac tromethamine	24
Preparation and evaluation of liposome with ropivacaine ion-pairing in local pain management	22
The effect of testosterone and antioxidants nanoliposomes on gene expressions and sperm parameters in asthenospermic individuals	22
Development of pediatric orally disintegrating mini-tablets containing atomoxetine hydrochloride-β-cyclodextrin inclusion complex using experimental design	20
Reckoning γ-Glutamyl-S-allylcysteine as a potential main protease (m^pro) inhibitor of novel SARS-CoV-2 virus identified using docking and molecular dynamics simulation	19
Influence of chitosan thioglycolic acid conjugate in improving bioavailability of an antiparkinson drug; Rasagiline Mesylate from transdermal patch	19
Nanostructured lipid carriers for enhanced in vitro and in vivo schistosomicidal activity of praziquantel: effect of charge	19
Development and optimization of tibezonium iodide and lignocaine hydrochloride containing novel mucoadhesive buccal tablets: a pharmacokinetic investigation among healthy humans	19
Enhanced skin penetration of Finasteride loaded DMSO-liposomes for the treatment of androgenic alopecia: comparison with conventional liposomes	17
Palatability of pediatric formulations: do rats predict aversiveness?	17
Novel co-crystal of 3-methylcinnamic acid with berberine (1:1): synthesis, characterization, and intestinal absorption property	16
Prediction of the molecular mechanism of eucommiae Cortex - Achyranthis bidentatae radix in the treatment of osteoarthritis: network pharmacology and molecular docking	16
Development of oral formulation of Lepidium seeds significantly decreases the high blood glucose levels in diabetic rats: in vitro formula	15
Preparation, characterization and in vitro evaluation of cisplatin-bound triblock polymeric micelle solution for ovarian cancer treatment	15
Study on co-delivery of pemetrexed disodium and Bcl-2 siRNA by poly-γ-glutamic acid-modified cationic liposomes for the inhibition of NSCLC	15
Solubilization, Hansen solubility parameters, and thermodynamic studies of delafloxacin in (transcutol + 1-butyl-3-methyl imidazolium hexafluorophosphate) mixtures	15
Comparative pharmacokinetic evaluation of glimepiride orodispersable and conventional tablets in rabbits	15
In vivo assessment of bone repair by an injectable nanocomposite scaffold for local co-delivery of autologous platelet-rich plasma and calcitonin in a rat model	15
Microneedles assisted controlled and improved transdermal delivery of high molecular drugs viain situforming depot thermoresponsive poloxamers gels in skin microchannels	14
In-vitro and in-vivo evaluation of taste-masked ibuprofen formulated in oral dry emulsions	14

Are European marketed acyclovir 5% cream products similar? Comparison with EU and US reference product	13
Chrysin-functionalized gold nanoparticles and paclitaxel exhibit synergistic impact on lung cancer cell lines via regulating the AKT/PPAR-ϒ/β-catenin pathway	12
Optimizing critical quality attributes of fast disintegrating tablets using artificial neural networks: a scientific benchmark study	12
Colon targeted dosage form of Capecitabine using folic acid anchored modified carbon nanotube: in vitro cytotoxicity, apoptosis and in vivo roentgenographic study	12
Synthesis of a PVA-GO drug delivery system for sustained release of 4-methyl umbelliferon	12
Liposomal delivery of Annona muricata leaves extract for the treatment of hepatocellular carcinoma	12
Development and characterization of 3D printed ethylene vinyl acetate (EVA) as drug delivery device for the treatment of overactive bladder	12
Exploration of polymethacrylate and Hypromellose for the development of a non-sulfhydryl ACE inhibitor mucoadhesive system using Box-Behnken design: in-vitro and ex-vivo evaluation	12
Empagliflozin containing chitosan-alginate nanoparticles in orodispersible film: preparation, characterization, pharmacokinetic evaluation and itsin-vitroanticancer activity	11
Simultaneous estimation of paclitaxel and erlotinib in plasma by liquid chromatography/(+) electrospray tandem mass spectrometry: application in formulation development and pharmacokinetics	11
Influence of hydrotrope on solubility and bioavailability of curcumin: its complex formation and solid-state characterization	11
Nisin and nisin-loaded nanoparticles: a cytotoxicity investigation	11
Comparison of oven drying and freeze drying methods for the production of fast melt films containing quetiapine fumarate	10
Development of a novel direct compressible co-processed excipient and its application for formulation of Mirtazapine orally disintegrating tablets	10
In-use stability studies: guidelines and challenges	10
TGF-β1 and FOXM1 siRNA co-loaded nanoparticles by disulfide crosslinked PEG-PDMAEMA for the treatment of triple-negative breast cancer and its bone metastases in vitro	10
Nanocrystals based mucosal delivery system: research advances	10
Targeted delivery of epirubicin to breast cancer cells using poly-aptamer DNA nanocarriers prepared by the RCA method with multiple repeats of aptamers of FOXM1 and AS1411	10
Co-encapsulation of metformin and ginger into the liposomes: in vitro characterization and in vivo anti-psoriasis evaluation	10
Nanocrystal formulations of mebendazole employing quality by design and molecular level insights by atomistic simulations	10
N-(levodopa) chitosan derivative based on click chemistry shows biological functionality in brain cells	10
Computer-aided optimization of carbidopa/levodopa orally disintegrating tablets	10
Formulation, biopharmaceutical evaluation and in-vitro screening of polyherbal phytosomes for breast cancer therapy	10
Stability-indicating green HPLC method for fixed-dose tablets containing remogliflozin etabonate and teneligliptin: an AQbD approach	10
Developing a rapid analytical method for simultaneous determination of apigenin and gallic acid: validation and application in a nanoliposomal formulation	9
Chitosan-coated alginate (CCA) nanoparticles for augmentation of topical antihistaminic activity of diphenhydramine:in-vitrooptimization, skin histopathology and pharmacodynamic studies with in	9
Formulation, optimization and full characterization of mirtazapine loaded aquasomes: a new technique to boost antidepressant effects	9
In vitro evaluation of physicochemical-dependent effects of polymeric nanoparticles on their cellular uptake and co-localization using pulmonary calu-3 cell lines	9
Phytochemical profiling and antioxidant evaluation of Rhododendron arboreum Sm leaf and flower: integrative analysis using advanced analytical techniques	8
Gingerol containing polymeric nanofibers: a healing touch for accelerated wound recovery	8
Intranasal galantamine/chitosan complex nanoparticles elicit neuroprotection potentials in rat brains via antioxidant effect	8
Lymphatic targeting of cilnidipine by designing and developing a nanostructured lipid carrier drug delivery system	7
Residence time and mixing capacity of a rotary tablet press feed frame	7
Nanoparticle-based delivery systems for phytochemicals in cancer therapy: molecular mechanisms, clinical evidence, and emerging trends	7
Experimental confirmation of antimicrobial effects of GdYVO ₄ :Eu ³⁺ nanoparticles	7
Ameliorated delivery of amphotericin B to macrophages using chondroitin sulfate surface-modified liposome nanoparticles	7
Evaluation of the anticancer activity of Origanum Marjoram as a safe natural drink for daily use	7
Correction	7
Curcumin-loaded microemulsion: formulation, characterization, and in vitro skin penetration	7
PEGylated drug delivery systems in the pharmaceutical field: past, present and future perspective	7
Solubilization of a novel antitumor drug ribociclib in water and ten different organic solvents at different temperatures	7
Ecofriendly phytosynthesized zirconium oxide nanoparticles as antibiofilm and quorum quenching agents against Acinetobacter baumannii	7
A comparative anticancer analysis of iron oxide nanoparticles of Hippophae rhamnoides and Cichorium intybus found in the Karakoram Range o	7
Optimization and assessment of three generation solid dispersion for enhancement of solubility and dissolution for montelukast sodium	7
Intranasal administration of innovative triamcinolone acetonide encapsulated cubosomal in situ gel: formulation and characterization	7
Metabolomic profiles altered by erlotinib encapsulated in poly(lactide-co-glycolide) nanoparticles in non-small cell lung cancer	7
Microneedle-assisted transdermal delivery of amlodipine besylate loaded nanoparticles	7
Physicochemical evaluation and pharmacodynamics of itraconazole-loaded liquid crystal precursor for vaginal delivery	6
Effects of water-soluble additive on the release profile and pharmacodynamics of triptorelin loaded in PLGA microspheres	6
Boosting the mechanical strength and solubility-enhancement properties of hydroxypropyl-β-cyclodextrin nanofibrous films	6

Design and evaluation of molecular organogel based on folic acid as a potential green drug carrier for oral route	6
Design of experiments and multivariate analysis approach to study dissolution stability of a modified-release drug product to support lean design strategies	6
Formulation of topical gel contains a novel benzoic acid derivative for skin infection treatment: in vitro and in vivo evaluations	6
Development and greenness assessment of a stability-indicating HPLC-DAD method for simultaneous determination of allopurinol and benzbromarone	6
Study on the taste-masking effect and mechanism of Acesulfame K on berberine hydrochloride	6
Establishment of quantitative methodology for sophoridine analysis and determination of its pharmacokinetics and bioavailability in rat	6
Development of UV–visible spectrophotometric methods for the quantitative andin silicostudies for cilazapril optimized by response surface methodology	6
Preparation and evaluation of a lipid-based drug delivery system to ımprove valsartan oral bioavailability: pharmacokinetic and pharmacodynamic analysis	6
Comparison between molecular dynamics potentials for simulation of graphene-based nanomaterials for biomedical applications	6
Dissolution thermodynamics and preferential solvation of genistein in some (ethanol + water) mixtures at different temperatures	6
Fabrication of a dual stimuli-responsive magnetic nanohydrogel for delivery of anticancer drugs	6
EthoLeciplex: a new tool for effective cutaneous delivery of minoxidil	6
Hydrophobic ion pairing with cationic derivatives of α-, ß-, and γ-cyclodextrin as a novel approach for development of a self-nano-emulsifying drug delivery system (SNEDDS) for oral delivery of hepari	6
Improving the 6-Aminopenicillanic acid release process using vermiculite-alginate biocomposite bead on drug delivery system	6
Interdigitation of lipids for vesosomal formulation of ergotamine tartrate with caffeine: a futuristic trend of intranasal route	6
A rapid solid form risk assessment workflow for ophthalmic drug candidates	6
Multivesicular liposomal depot system for sustained delivery of risperidone: development, characterization, and toxicity assessment	6
Liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for determination of free and total dabigatran in human plasma and its application to a pharmacokinetic study	6
Targeted antibacterial and anticancer therapeutics: PEGylated liposomal delivery of turmeric and cinnamon extracts- in vitro and in vivo e	6
A method for the tribological assessment of oral pharmaceutical liquids	5
Development and evaluation of tofacitinib transdermal system for the treatment of rheumatoid arthritis in rats	5
In vivo and in vitro evaluation of pulmonary administration of itraconazole nanostructured lipid carriers for pulmonary aspergillosis	5
In vitro anti-melanoma activity of imiquimod in ultradeformable nanovesicles	5
Investigation of mixing homogeneity of binary particle systems in high-shear wet granulator by DEM	5
Dual loading of Nigella sativa oil-atorvastatin in chitosan–carboxymethyl cellulose nanogel as a transdermal delivery system	5
Effect of mechanochemical inclusion of triamterene into sulfobutylether-β-cyclodextrin and its improved dissolution behavior	5
Non-pigmented laser hair removal mediated via sepia melanin nanoparticles: in vivo study on albino mice	5
Transferrin functionalized poloxamer-chitosan nanoparticles of metformin: physicochemical characterization, in-vitro, and Ex-vivo studies	5
Solid state characterization, solubility, intrinsic dissolution and stability behavior of allopurinol hydrochloride salt	5
Spray coverage analysis of topical sprays formed by cold thermoreversible hydrogels	5
Revisiting the significance of nano-vitamin D for food fortification and therapeutic application	5
Crystal engineering of valproic acid and carbamazepine to improve hygroscopicity and dissolution profile	5
Fabrication of gelatin/silk fibroin/phage nanofiber scaffold effective against multidrug resistantPseudomonas aeruginosa	5
Raloxifene HCl – quercetin co-amorphous system: preparation, characterization, and investigation of its behavior in phosphate buffer	5
Glimepiride/hydroxypropyl-β-cyclodextrin inclusion compound: preparation, characterization, and evaluation	5
Improving cellular uptake and synergetic anti-tumor effects of magnolol and Brucea javanica oil through self-microemulsion	5
Traditional Mongolian medicine Wu-Lan thirteen-flavor decoction protects rat from hypertension-induced renal injury via aryl hydrocarbon receptor-mediated pathway	5
Development of purified cashew gum mucoadhesive buccal tablets containing nystatin for treatment of oral candidiasis	5
Quantitative analysis of solid dosage forms of Atenolol by Raman spectroscopy	5
Nintedanib and miR-29b co-loaded lipoplexes in idiopathic pulmonary fibrosis: formulation, characterization, and in vitro evaluation	5
Spray dried nanospheres for inclusion complexes of cefpodoxime proxetil with β-cyclodextrin, 2-hydroxypropyl-β-cyclodextrin and methyl-β-cyclodextrin: improved dissolution and enhanced antibacterial a	5
Incentives to promote the US pharmaceutical innovation: empirical research based on the case of Epogen	5
Extemporaneous printing of diclofenac orodispersible films for pediatrics	5