Archiv der Pharmazie

Papers
(The TQCC of Archiv der Pharmazie is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)
ArticleCitations
Discovery of sulfadrug–pyrrole conjugates as carbonic anhydrase and acetylcholinesterase inhibitors158
1,2,3‐Triazole hybrids as anticancer agents: A review118
Coumarin derivatives with anticancer activities: An update69
1,2,3‐Triazole hybrids with anti‐HIV‐1 activity68
Novel benzoic acid derivatives: Synthesis and biological evaluation as multitarget acetylcholinesterase and carbonic anhydrase inhibitors66
Synthesis, characterization, biological evaluation, and in silico studies of novel 1,3‐diaryltriazene‐substituted sulfathiazole derivatives60
Novel metabolic enzyme inhibitors designed through the molecular hybridization of thiazole and pyrazoline scaffolds60
Determination of the inhibition profiles of pyrazolyl–thiazole derivatives against aldose reductase and α‐glycosidase and molecular docking studies59
1,3,5‐Triazine: A versatile pharmacophore with diverse biological activities55
Synthesis, characterization, molecular docking, and biological activities of coumarin–1,2,3‐triazole‐acetamide hybrid derivatives53
Aromatase inhibitors: Role in postmenopausal breast cancer46
Design and discovery of new 1,2,4‐triazolo[4,3‐c]quinazolines as potential DNA intercalators and topoisomerase II inhibitors46
Pharmacophore‐linked pyrazolo[3,4‐d]pyrimidines as EGFR‐TK inhibitors: Synthesis, anticancer evaluation, pharmacokinetics, and in silico mechanistic studies45
Design, synthesis, and biological activity of novel dithiocarbamate‐methylsulfonyl hybrids as carbonic anhydrase inhibitors45
Synthesis and antidiabetic evaluation of benzimidazole‐tethered 1,2,3‐triazoles43
Recent update on antibacterial and antifungal activity of quinoline scaffolds43
Novel 2‐cyanoacrylamido‐4,5,6,7‐tetrahydrobenzo[b]thiophene derivatives as potent anticancer agents42
Toad venom: A comprehensive review of chemical constituents, anticancer activities, and mechanisms37
Synthesis and in vitro carbonic anhydrases and acetylcholinesterase inhibitory activities of novel imidazolinone‐based benzenesulfonamides37
Natural indole‐containing alkaloids and their antibacterial activities37
Design, synthesis, molecular docking, and anticancer evaluations of 1‐benzylquinazoline‐2,4(1H,3H)‐dione bearing different moieties as VEGFR‐2 inhibitors37
Pyrazole–coumarin and pyrazole–quinoline chalcones as potential antitubercular agents36
Phthalazine‐based VEGFR‐2 inhibitors: Rationale, design, synthesis, in silico, ADMET profile, docking, and anticancer evaluations35
Design, synthesis, molecular modeling, and antimicrobial potential of novel 3‐[(1H‐pyrazol‐3‐yl)imino]indolin‐2‐one derivatives as DNA gyrase inhibitors34
5‐(4‐Methoxybenzylidene)thiazolidine‐2,4‐dione‐derived VEGFR‐2 inhibitors: Design, synthesis, molecular docking, and anticancer evaluations34
Design, synthesis, molecular docking, anticancer evaluations, and in silico pharmacokinetic studies of novel 5‐[(4‐chloro/2,4‐dichloro)benzylidene]thiazolidine‐2,4‐dione derivatives as VEGFR‐2 inhibit32
Quinoline‐based promising anticancer and antibacterial agents, and some metabolic enzyme inhibitors31
Synthesis, antimicrobial evaluation, DNA gyrase inhibition, and in silico pharmacokinetic studies of novel quinoline derivatives30
In vitro and in silico studies of fluorinated 2,3‐disubstituted thiazolidinone‐pyrazoles as potential α‐amylase inhibitors and antioxidant agents30
Pyridine‐derived VEGFR‐2 inhibitors: Rational design, synthesis, anticancer evaluations, in silico ADMET profile, and molecular docking29
New 1,2,3‐triazole–(thio)barbituric acid hybrids as urease inhibitors: Design, synthesis, in vitro urease inhibition, docking study, and molecular dynamic simulation29
Synthesis of N‐alkylated pyrazolo[3,4‐d]pyrimidine analogs and evaluation of acetylcholinesterase and carbonic anhydrase inhibition properties28
In vivo‐ and in silico‐driven identification of novel synthetic quinoxalines as anticonvulsants and AMPA inhibitors28
Ecofriendly synthesis of pyrano[2,3‐d]pyrimidine derivatives and related heterocycles with anti‐inflammatory activities28
Synthesis and biological evaluation of some 1‐naphthol derivatives as antioxidants, acetylcholinesterase, and carbonic anhydrase inhibitors27
Oxadiazole: A highly versatile scaffold in drug discovery27
Synthesis and in silico studies of triazene‐substituted sulfamerazine derivatives as acetylcholinesterase and carbonic anhydrases inhibitors26
Novel pyrazole‐clubbed thiophene derivatives via Gewald synthesis as antibacterial and anti‐inflammatory agents26
Design, synthesis, molecular docking, and some metabolic enzyme inhibition properties of novel quinazolinone derivatives25
Indole/isatin‐containing hybrids as potential antibacterial agents25
Cinnamic acid hybrids as anticancer agents: A mini‐review25
Design, synthesis, docking, ADMET profile, and anticancer evaluations of novel thiazolidine‐2,4‐dione derivatives as VEGFR‐2 inhibitors25
Anticancer activity of novel 3‐(furan‐2‐yl)pyrazolyl and 3‐(thiophen‐2‐yl)pyrazolyl hybrid chalcones: Synthesis and in vitro studies25
Discovery of novel pyrazole and pyrazolo[1,5‐a]pyrimidine derivatives as cyclooxygenase inhibitors (COX‐1 and COX‐2) using molecular modeling simulation25
Synthesis of benzamide derivatives with thiourea‐substituted benzenesulfonamides as carbonic anhydrase inhibitors24
New 1,3,4‐oxadiazoles linked with the 1,2,3‐triazole moiety as antiproliferative agents targeting the EGFR tyrosine kinase24
N‐Substituted‐4‐phenylphthalazin‐1‐amine‐derived VEGFR‐2 inhibitors: Design, synthesis, molecular docking, and anticancer evaluation studies24
Azetidines of pharmacological interest24
Risk assessment for nitrosated pharmaceuticals: A future perspective in drug development23
Novel 1,2,4‐triazole derivatives: Design, synthesis, anticancer evaluation, molecular docking, and pharmacokinetic profiling studies23
Synthesis, molecular docking, and biological activities of new cyanopyridine derivatives containing phenylurea22
Synthesis, characterization, and biological evaluation of some novel Schiff bases as potential metabolic enzyme inhibitors22
Design and synthesis of pyrazole–pyrazoline hybrids as cancer‐associated selective COX‐2 inhibitors22
Synthesis, characterization, and biological studies of chalcone derivatives containing Schiff bases: Synthetic derivatives for the treatment of epilepsy and Alzheimer's disease21
Design, synthesis, and in vitro biological evaluation of novel thiazolopyrimidine derivatives as antileishmanial compounds21
Synthesis of novel sulfonamides with anti‐Alzheimer and antioxidant capacities21
Ginkgo biloba in the management of the COVID‐19 severity21
Discovery of novel furo[2,3‐d]pyrimidin‐2‐one–1,3,4‐oxadiazole hybrid derivatives as dual antiviral and anticancer agents that induce apoptosis20
Advances in 2‐substituted benzothiazole scaffold‐based chemotherapeutic agents20
Cytotoxic and antimicrobial potential of benzimidazole derivatives20
Biscoumarin–pyrimidine conjugates as potent anticancer agents and binding mechanism of hit candidate with human serum albumin20
Design, synthesis, and biological evaluation of novel morpholinated isatin–quinoline hybrids as potent anti‐breast cancer agents20
Synthesis and in vitro study of antiproliferative benzyloxy dihydropyrimidinones20
Benzimidazole hybrids as anticancer drugs: An updated review on anticancer properties, structure–activity relationship, and mechanisms of action (2019–2021)19
Design, synthesis, and biological evaluation of isatin‐indole‐3‐carboxaldehyde hybrids as a new class of xanthine oxidase inhibitors19
Novel benzo[b]xanthene derivatives: Bismuth(III) triflate‐catalyzed one‐pot synthesis, characterization, and acetylcholinesterase, glutathione S‐transferase, and butyrylcholinesterase inhibitor19
(+)‐Camphor and (−)‐borneol derivatives as potential anti‐orthopoxvirus agents19
Reprogramming of antibiotics to combat antimicrobial resistance18
Anticancer activity of bisindole alkaloids derived from natural sources and synthetic bisindole hybrids18
1,2,4‐Triazole hybrids with potential antibacterial activity against methicillin‐resistant Staphylococcus aureus18
1,2,3‐Triazole‐linked 5‐benzylidene (thio)barbiturates as novel tyrosinase inhibitors and free‐radical scavengers17
Design, synthesis, and biological evaluation of new pyrazoloquinazoline derivatives as dual COX‐2/5‐LOX inhibitors17
Potential antibacterial and antifungal activities of novel sulfamidophosphonate derivatives bearing the quinoline or quinolone moiety17
Synthesis and anticancer properties of novel hydrazone derivatives incorporating pyridine and isatin moieties17
Thieno[2,3‐b]pyridine amines: Synthesis and evaluation of tacrine analogs against biological activities related to Alzheimer's disease16
Design, synthesis, and biological evaluation of imidazopyridine‐linked thiazolidinone as potential anticancer agents16
(E)‐2‐(2‐Allylidenehydrazinyl)thiazole derivatives: Design, green synthesis, in silico and in vitro antimycobacterial and radical scavenging studies16
Development of novel indole‐linked pyrazoles as anticonvulsant agents: A molecular hybridization approach16
Structure–activity relationship studies of indolin‐2‐one derivatives as vascular endothelial growth factor receptor inhibitors and anticancer agents16
Biological functions of kojic acid and its derivatives in medicine, cosmetics, and food industry: Insights into health aspects16
The anticancer activity of carbazole alkaloids15
New N‐phenylacetamide‐linked 1,2,3‐triazole‐tethered coumarin conjugates: Synthesis, bioevaluation, and molecular docking study15
In silico molecular docking studies of oxadiazole and pyrimidine bearing heterocyclic compounds as potential antimicrobial agents15
Enzyme inhibition, molecular docking, and density functional theory studies of new thiosemicarbazones incorporating the 4‐hydroxy‐3,5‐dimethoxy benzaldehyde motif15
The antimalarial activity of indole alkaloids and hybrids15
Phyllobilins as a challenging diverse natural product class: Exploration of pharmacological activities15
Design, synthesis, and molecular docking studies of thiazolidinediones as PPAR‐γ agonists and thymidylate synthase inhibitors15
Isatin thiazoles as antidiabetic: Synthesis, in vitro enzyme inhibitory activities, kinetics, and in silico studies15
Revealing the role of the benzyloxy pharmacophore in the design of a new class of monoamine oxidase‐B inhibitors14
Synthesis, characterization, crystal structure, α‐glycosidase, and acetylcholinesterase inhibitory properties of 1,3‐disubstituted benzimidazolium salts14
Chemical composition and antimicrobial activity of Osage orange (Maclura pomifera) leaf extracts13
New quinoxalin‐1,3,4‐oxadiazole derivatives: Synthesis, characterization, in vitro biological evaluations, and molecular modeling studies13
Thiophene‐containing compounds with antimicrobial activity13
A comprehensive review of recent advances in the biological activities of 1,2,4‐oxadiazoles13
Synthesis and anticancer activity of ethyl 5‐amino‐1‐N‐substituted‐imidazole‐4‐carboxylate building blocks13
Novel benzenesulfonamide‐bearing pyrazoles and 1,2,4‐thiadiazoles as selective carbonic anhydrase inhibitors13
New indomethacin analogs as selective COX‐2 inhibitors: Synthesis, COX‐1/2 inhibitory activity, anti‐inflammatory, ulcerogenicity, histopathological, and docking studies13
Pharmacological report of recently designed multifunctional coumarin and coumarin–heterocycle derivatives13
Synthesis and docking calculations of tetrafluoronaphthalene derivatives and their inhibition profiles against some metabolic enzymes13
PXR–ABC drug transporters/CYP‐mediated ursolic acid transport and metabolism in vitro and vivo13
Silver–N‐heterocyclic carbene complexes‐catalyzed multicomponent reactions: Synthesis, spectroscopic characterization, density functional theory calculations, and antibacterial study13
Exploration of thiazolidine‐2,4‐diones as tyrosine kinase inhibitors: Design, synthesis, ADMET, docking, and antiproliferative evaluations13
Design, synthesis, biological activity, molecular docking, and molecular dynamics of novel benzimidazole derivatives as potential AChE/MAO‐B dual inhibitors12
Effect of substituents in the A and B rings of chalcones on antiparasite activity12
Design, synthesis, and characterization of PROTACs targeting the androgen receptor in prostate and lung cancer models12
Investigation of HMG‐CoA reductase inhibitory and antioxidant effects of various hydroxycoumarin derivatives12
Targeting VEGFR‐2 by new quinoxaline derivatives: Design, synthesis, antiproliferative assay, apoptosis induction, and in silico studies12
Novel N‐benzylpiperidine derivatives of 5‐arylisoxazole‐3‐carboxamides as anti‐Alzheimer's agents12
Resveratrol isoforms and conjugates: A review from biosynthesis in plants to elimination from the human body12
N‐Substituted pyrimidinethione and acetophenone derivatives as a new therapeutic approach in diabetes12
Synthesis and in vitro antileishmanial efficacy of novel benzothiadiazine‐1,1‐dioxide derivatives12
Design, synthesis, and molecular docking study of new monastrol analogues as kinesin spindle protein inhibitors11
The current scenario on anticancer activity of artemisinin metal complexes, hybrids, and dimers11
Synthesis and antimalarial and anticancer evaluation of 7‐chlorquinoline‐4‐thiazoleacetic derivatives containing aryl hydrazide moieties11
Discovery of oxindole‐based FLT3 inhibitors as a promising therapeutic lead for acute myeloid leukemia carrying the oncogenic ITD mutation11
Some phenolic natural compounds as carbonic anhydrase inhibitors: An in vitro and in silico study11
Design, synthesis, cytotoxicity, and molecular docking studies of novel thiazolyl–hydrazone derivatives as histone lysine acetyl‐transferase inhibitors and apoptosis inducers11
Synthesis and antimicrobial evaluation of new nitric oxide‐donating fluoroquinolone/oxime hybrids11
New 4‐phenylpiperazine‐carbodithioate‐N‐phenylacetamide hybrids: Synthesis, in vitro and in silico evaluations against cholinesterase and α‐glucosidase enzymes11
Design, synthesis, and α‐glucosidase‐inhibitory activity of phenoxy‐biscoumarin–N‐phenylacetamide hybrids11
Design, synthesis, and cytotoxicity screening of new synthesized imidazolidine‐2‐thiones as VEGFR‐2 enzyme inhibitors10
Dual EGFR/VEGFR2 inhibitors and apoptosis inducers: Synthesis and antitumor activity of novel pyrazoline derivatives10
Synthesis and evaluation of novel xanthene‐based thiazoles as potential antidiabetic agents10
Discovery of 2,4‐diaminopyrimidine derivatives targeting p21‐activated kinase 4: Biological evaluation and docking studies10
Facile synthesis of C6‐substituted benz[4,5]imidazo[1,2‐a]quinoxaline derivatives and their anticancer evaluation10
Synthesis and biological evaluation of new coumarin derivatives as cytotoxic agents10
3D‐QSAR and scaffold hopping based designing of benzo[d]ox‐azol‐2(3H)‐one and 2‐oxazolo[4,5‐b]pyridin‐2(3H)‐one derivatives as selective aldehyde dehydrogenase 1A1 inhibito10
Design, synthesis, in silico ADMET, docking, and antiproliferative evaluations of [1,2,4]triazolo[4,3‐c]quinazolines as classical DNA intercalators10
Cyanopropyl functionalized benzimidazolium salts and their silver N‐heterocyclic carbene complexes: Synthesis, antimicrobial activity, and theoretical analysis9
Potential targeting of Hep3B liver cancer cells by lupeol isolated from Avicennia marina9
In silico studies, nitric oxide, and cholinesterases inhibition activities of pyrazole and pyrazoline analogs of diarylpentanoids9
Design, synthesis, docking, and anticancer evaluations of phthalazines as VEGFR‐2 inhibitors9
Design, synthesis, and molecular docking study of novel quinoline‐based bis‐chalcones as potential antitumor agents9
Evaluation of isoindole derivatives: Antioxidant potential and cytotoxicity in the HT‐29 colon cancer cells9
Simultaneous analysis of oxytetracycline hydrochloride, lidocaine, and bromhexine hydrochloride in the presence of many interfering excipients9
Antiprotozoal agents: How have they changed over a decade?9
Influence of the pKa value on the antioxidant activity of licorice flavonoids under solvent‐mediated effects9
Synthesis of novel 4,5‐dihydropyrrolo[1,2‐a]quinoxalines, pyrrolo[1,2‐a]quinoxalin]‐2‐ones and their antituberculosis and anticancer activity9
Synthesis and biological evaluation of substituted pyrrolidines and pyrroles as potential anticancer agents9
Probing simple structural modification of α‐mangostin on its cholinesterase inhibition and cytotoxicity9
Green synthesis of pregabalin‐stabilized gold nanoclusters and their applications in sensing and drug release9
Current perspectives on naturally occurring saponins as anticancer agents9
Synthesis and anticancer activities of some new coumarin derivatives including the triazole ring and their in silico molecular docking studies9
Novel 2‐substituted thioquinazoline‐benzenesulfonamide derivatives as carbonic anhydrase inhibitors with potential anticancer activity9
Upregulation of BAX and caspase‐3, as well as downregulation of Bcl‐2 during treatment with indeno[1,2‐b]quinoxalin derivatives, mediated apoptosis in human cancer cells9
Design, synthesis, antibacterial evaluation, and computational studies of hybrid oxothiazolidin–1,2,4‐triazole scaffolds9
Design, synthesis, and biological evaluation of new urolithin amides as multitarget agents against Alzheimer's disease9
Novel promising benzoxazole/benzothiazole‐derived immunomodulatory agents: Design, synthesis, anticancer evaluation, and in silico ADMET analysis9
Comparison of extraction efficiency and selectivity between low‐temperature pressurized microwave‐assisted extraction and prolonged maceration9
Synthesis and radioligand‐binding assay of 2,5‐disubstituted thiadiazoles and evaluation of their anticonvulsant activities9
Design, synthesis, biological evaluation, and in silico studies of 2‐aminobenzothiazole derivatives as potent PI3Kα inhibitors8
Bioevaluation of synthetic pyridones as dual inhibitors of α‐amylase and α‐glucosidase enzymes and potential antioxidants8
Piperazine and piperidine‐substituted 7‐hydroxy coumarins for the development of anti‐inflammatory agents8
Molecular hydrogen (H2) as a potential treatment for acute and chronic fatigue8
Design and synthesis of benzenesulfonamide‐linked imidazo[2,1‐b][1,3,4]thiadiazole derivatives as carbonic anhydrase I and II inhibitors8
Insights into the chemistry and therapeutic potential of acrylonitrile derivatives8
Triazoloquinazoline derived classical DNA intercalators: Design, synthesis, in silico ADME profile, docking, and antiproliferative evaluations8
A new series of hydrazones as small‐molecule aldose reductase inhibitors8
Zinc(II) complexation strategy for ultra‐sensitive fluorimetric estimation of molnupiravir: Applications and greenness evaluation8
1,2,4‐Triazole and benzimidazole fused dihydropyrimidine derivatives: Design, green synthesis, antibacterial, antitubercular, and antimalarial activities8
Activating endogenous resolution pathways by soluble epoxide hydrolase inhibitors for the management of COVID‐198
Synthesis and biological evaluation of coumarin‐thiazole hybrids as selective carbonic anhydrase IX and XII inhibitors8
Synthesis and biological evaluation of novel isoxazole derivatives from acridone8
Design, synthesis, biological evaluation, and docking studies of some novel chalcones as selective COX‐2 inhibitors8
Synthesis of new 7‐amino‐3,4‐dihydroquinolin‐2(1H)‐one‐peptide derivatives and their carbonic anhydrase enzyme inhibition, antioxidant, and cytotoxic activities8
Recent advances in indole dimers and hybrids with antibacterial activity against methicillin‐resistant Staphylococcus aureus8
Antitumor and multikinase inhibition activities of some synthesized coumarin and benzofuran derivatives8
Discovery of novel triazolophthalazine derivatives as DNA intercalators and topoisomerase II inhibitors8
Synthesis and biological evaluation of Val–Val dipeptide–sulfonamide conjugates8
Binding of boswellic acids to functional proteins of the SARS‐CoV‐2 virus: Bioinformatic studies8
Synthesis, structural characterization, and biological studies of ATBS–M complexes (M(II) = Cu, Co, Ni, and Mn): Access for promising antibiotics and anticancer agents8
Design, synthesis, and docking of novel thiazolidine‐2,4‐dione multitarget scaffold as new approach for cancer treatment8
A new series of benzoxazole‐based SIRT1 modulators for targeted therapy of non‐small‐cell lung cancer7
Antiproliferative effects of chalcones on T cell acute lymphoblastic leukemia‐derived cells: Role of PKCβ7
Therapeutic potential of 1,2,3‐triazole hybrids for leukemia treatment7
Eugenol carbonate activity against Plasmodium falciparum, Leishmania braziliensis, and Trypanosoma cruzi7
Bioevaluation of quinoline‐4‐carbonyl derivatives of piperazinyl‐benzothiazinones as promising antimycobacterial agents7
Pyrazole/pyrazoline as an excellent pharmacophore in the design of carbonic anhydrase inhibitors (2018–2022)7
Drug re‐engineering and repurposing: A significant and rapid approach to tuberculosis drug discovery7
Design, synthesis, evaluation, and molecular modeling studies of indolyl oxoacetamides as potential pancreatic lipase inhibitors7
Design, synthesis, and in silico studies of tetrahydropyrimidine analogs as urease enzyme inhibitors7
Tandem synthesis, cytotoxicity, and in silico study of new 1,3,4‐oxadiazoles as potential thymidylate synthase inhibitors7
New nanodrug design for cancer therapy: Its synthesis, formulation, in vitro and in silico evaluations7
Anti‐inflammatory activity of pyridazinones: A review7
The antimalarial activity of 1,2,4‐trioxolane/trioxane hybrids and dimers: A review7
Synthesis and antimicrobial activity of new 2‐piperazin‐1‐yl‐N‐1,3‐thiazol‐2‐ylacetamides of cyclopenta[c]pyridines and pyrano[3,4‐c]pyridines7
Hybridization‐based design of novel anticholinesterase indanone–carbamates for Alzheimer's disease: Synthesis, biological evaluation, and docking studies7
New [1,2,4]triazolo[4,3‐c]quinazoline derivatives as vascular endothelial growth factor receptor‐2 inhibitors and apoptosis inducers: Design, synthesis, docking, and antiproliferative evaluatio7
Synthesis and antitumor potential of new arylidene ursolic acid derivatives via caspase‐8 activation7
Phthalimide‐tethered imidazolium salts: Synthesis, characterization, enzyme inhibitory properties, and in silico studies7
Synthesis of new arylazopyrazoles as apoptosis inducers: Candidates to inhibit proliferation of MCF‐7 cells7
Design, synthesis, and biological evaluation of novel benzimidazole derivatives as sphingosine kinase 1 inhibitor7
Synthesis, in silico, and in vitro studies of novel dopamine D2 and D3 receptor ligands7
Recent updates on 1,2,3‐, 1,2,4‐, and 1,3,5‐triazine hybrids (2017–present): The anticancer activity, structure–activity relationships, and mechanisms of action7
Design and synthesis of novel quinazolinone‐based fibrates as PPARα agonists with antihyperlipidemic activity7
Synthesis of new 1,2,4‐triazole–(thio)semicarbazide hybrid molecules: Their tyrosinase inhibitor activities and molecular docking analysis7
Pyrazole scaffold‐based derivatives: A glimpse of α‐glucosidase inhibitory activity, SAR, and route of synthesis7
Design, synthesis, and antiproliferative effect of 2,9‐bis[4‐(pyridinylalkylaminomethyl)phenyl]‐1,10‐phenanthroline derivatives on human leukemic cells by targeting G‐quadruplex7
Development of new Alzheimer's disease drug candidates using donepezil as a key model7
Synthesis, docking studies, and pharmacological evaluation of 2‐hydroxypropyl‐4‐arylpiperazine derivatives as serotoninergic ligands7
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