OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Toxicological Sciences is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Glasgow coma scale may be a predictive factor for delayed neurological sequelae after carbon monoxide poisoning: a retrospective analysis of a nationwide multicenter observational registry in Japan	18
Long-term exposure to urban particulate matter exacerbates mortality after ischemic stroke in mice	16
Per- and polyfluoroalkyl substances: toxicokinetics, exposure and health risks	15
Histological differences between the central and peripheral areas of the testes of busulfan-administered mice	13
Acyl-CoA:diacylglycerol acyltransferase 1 inhibition in the small intestine increases plasma transaminase activity via the activation of protein kinase C pathway	11
Lack of human relevance for rat developmental toxicity of flumioxazin is revealed by comparative heme synthesis assay using embryonic erythroid cells derived from human and rat pluripotent stem cells	11
Cadmium inhibits forskolin-induced differentiation of human placental BeWo cells	10
Neuro-protective effects of n-butylphthalide on carbon monoxide poisoning rats by modulating IL-2, AKT and BCL-2	9
Identification of postmortem product of amlodipine decomposition by hemoglobin with LC-Q-Orbitrap-MS	9
Identification of apoptotic pathways in zearalenone-treated mouse sertoli cells	8
Characterization of the toxicological findings from 90-day and 2-year repeated-dose toxicity studies of pesticides in rats	8
Activation of the arylhydrocarbon receptor through maternal beta-naphthoflavone exposure in the neonatal kidney	8
False-negative chemicals in ESR-based photosafety test (ESR-PT) and their significance for photosafety evaluations: examples of bithionol, fenticlor and cilnidipine	8
Diphenylarsinic acid induced astrocyte-preferential cell-type-specific aberrant activation of signal transduction related to oxidative stress, MAP kinase activation, transcription factor regulation, a	8
Spatio-temporal distribution of reactive sulfur species during methylmercury exposure in the rat brain	7
Spatial localization of cadmium and metallothionein in the kidneys of mice at the early phase of cadmium accumulation	7
<i>In vivo</i> analysis of acute eletropharmacological effects of proton pump inhibitors using halothane-anesthetized dogs: a translational study of cardiovascular adverse events	7
Human gut microbiota influences drug-metabolizing enzyme hepatic Cyp3a: A human flora-associated mice study	7
Methylthioacetic acid, a derivative of aroma compounds from <i>Cucumis melo</i> var. <i>conomon</i> dose-dependently triggers differentiation and apoptosis of RCM-1 human color	7
Evaluation of circulating miR-216a and miR-217 as biomarkers of pancreatic damage in the L-arginine-induced acute pancreatitis mouse model	7
Variation and classification of chemically-induced zebrafish malformations for the ICH S5 (R3) guideline: an atlas for zebrafish teratogenesis	7
Oxidative stress-induced TET1 upregulation mediates active DNA demethylation in human gastric epithelial cells	7
Oxycodone alleviates LPS-induced neuroinflammation by regulating the CREB/miR-181c/PDCD4 axis	7
Male rat-specific fatty change in liver by DS-1971a: Elevation in phospholipids and adenosine as early responses to the fatty change in male rat-derived primary hepatocytes	6
Comparison of the acceptable surface limits derived from the skin sensitization potency for workers and swab residue limits determined from the permitted daily exposure derived from the systemic effec	6

Dabrafenib stimulates autophagy in thyroid carcinoma cells via HMGB-1	6
Cadmium mediates pyroptosis of human dermal lymphatic endothelial cells in a NLRP3 inflammasome-dependent manner	6
Effect of secondary particle size of nickel oxide nanoparticles on cytotoxicity in A549 cells	6
Investigation of additional suitable positive controls in the human Cell Line Activation Test	6
Comprehensive molecular docking on the AlphaFold-predicted protein structure proteome: identifying target protein candidates for puberulic acid	6
Constitutive expression of cytochrome P450 1B1 endows testicular Leydig cells with susceptibility to 7,12-dimethylbenzanthracene-induced cell death	6
Propofol improves ischemia reperfusion-induced liver fibrosis by regulating lncRNA HOXA11-AS	6
Pharmacokinetics of tacrolimus following an overdose in a patient with extreme obesity and genotype <i>CYP3A53/3</i>: a case report	6
Anticancer agent doxorubicin toxicity to <i>in vitro X. laevis</i> tadpole organ heart and mature frog heart and liver mitochondria	6
Dihydropyrazine activates the CAMKK2-AMPK-ULK1 signaling pathway in human hepatoma HepG2 cells	6
Melatonin therapy reverses lead exposure-induced testicular damage in rats despite the lack of effect on serum testosterone levels	6
<i>Drosophila melanogaster</i> as potential alternative animal model for evaluating acute inhalation toxicity	5
Potential of connexin 32 as a predictive marker for drug-induced cholestatic liver injury in a collagen vitrigel-culture model of HepG2-NIAS cells, a new subline of HepG2 cells, with bile canaliculus-	5
Development challenges for carcinogenicity risk assessments of topical drugs	5
Amelioration of lipopolysaccharides-induced impairment of fear memory acquisition by alpha-glycosyl isoquercitrin through suppression of neuroinflammation in rats	5
Plasma membrane damage triggered by benzalkonium chloride and cetylpyridinium chloride induces G<sub>0</sub>/G<sub>1</sub> cell cycle arrest via Cdc6 reduction in human lung ep	5
Screening and identification of differential metabolites in serum and urine of bamaxiang pigs bitten by <i>trimeresurus stejnegeri</i> based on UPLC-Q-TOF/MS metabolomics technology	5
No obvious toxicological influences of 50 μL microsampling from rats administered phenacetin as a drug with hematological toxicity	5
Prevention of prolactin reduction: a novel strategy countering multi-generational growth retardation caused by maternal exposure to 2,3,7,8-tetrachlorodibenzo-<i>p</i>-dioxin	5
Evaluation of neurotoxicity of anticancer drugs using nematode <i>Caenorhabditis elegans</i> as a model organism	5
Lipopolysaccharide administration increases the susceptibility of mitochondrial permeability transition pore opening via altering adenine nucleotide translocase conformation in the mouse liver	5
Triphenylbismuth dichloride inhibits human glyoxalase I and induces cytotoxicity in cultured cancer cell lines	5
Carcinogenicity and chronic toxicity of butyl methacrylate in rats and mice by a two-year inhalation study	5
Establishment of hyperoxic cell culture system for predicting drug-induced liver injury: reducing accumulated lipids in hepatocytes derived from chimeric mice with humanized liver	5
Transcriptome analysis in various cell lines exposed to nitric oxide	4
Induction of systemic inflammation by welding fume exposure in office workers as well as welders in welding factories	4
A physiologically based kinetic modeling of ethyl <i>tert</i>-butyl ether in humans–An illustrative application of quantitative structure-property relationship and Monte Carlo simulation	4
Successful multimodal treatment of venlafaxine overdose-induced catecholamine-refractory shock: a case report	4
Effects of microsampling on toxicity evaluation of 1-naphthylisothiocyanate (ANIT), a hepatotoxic substance, in a mouse toxicity study	4
Nafamostat mesylate sensitizes ovarian cancer cells to carboplatin by promoting the ZNF24-mediated inhibition of WNT2B	4
Comparative sensitivity of laboratory animals used for preclinical convulsion risk assessment to drug-induced convulsion	4
Comparative study of susceptibility to methylmercury cytotoxicity in cell types composing rat peripheral nerves: a higher susceptibility of dorsal root ganglion neurons	4
Effects of food restriction on toxicological parameters in juvenile rats	4
Impact of selenium content in fetal bovine serum on ferroptosis susceptibility and selenoprotein expression in cultured cells	4
Toxicokinetic evaluation during intoxication of psychotropic drugs using brain microdialysis in mice	4
Incorporation of target safety review in drug discovery	3
DTox: A deep neural network-based <i>in visio</i> lens for large scale toxicogenomics data	3
Post-mortem interaction between methidathion and human serum albumin in blood	3
Resin monomers induce apoptosis of the pulp–dentin complex through the mitochondrial pathway	3
Ephedrine alleviates bleomycin-induced pulmonary fibrosis by inhibiting epithelial-mesenchymal transition and restraining NF-κB signaling	3
Toxicological effects of Sb(III), Sb(V), and NMG-Sb(V) in human lung, kidney, and liver cells: cytotoxicity and fibrotic factor induction	3
Dexmedetomidine attenuates acute stress-induced liver injury in rats by regulating the miR-34a-5p/ROS/JNK/p38 signaling pathway	3
Methylmercury-induced brain neuronal death in CHOP-knockout mice	3
Testosterone contributes sex differences of urinary biomarkers for nephrotoxicity in rats	3
CREB is a potential marker associated with drug-induced liver injury: Identification and validation through transcriptome database analysis	3
Developing a GNN-based AI model to predict mitochondrial toxicity using the bagging method	3
An update on ototoxicity: from a genetic perspective	3
Integrating mathematical approaches (IMAS): Novel methodology for predicting dermal absorption rates of chemicals under finite dose conditions	3
Paternal methamphetamine exposure differentially affects first and second generations in mice	3
Optimisation of Photo-KeratinoSens™ for <i>in vitro</i> photoallergenicity assessment	3

A probabilistic approach for estimating human exposure to polychlorinated biphenyls via tuna consumption	3
Expression profiles of purinergic P1 and P2 receptors in cultured bovine aortic endothelial cells, bovine aortic smooth muscle cells, and human vascular endothelial EA.hy926 cells	3
Small noncoding RNA dysregulation is implicated in manganism in a rat model of methylcyclopentadienyl manganese tricarbonyl-induced unrepaired striatum damage	3
Slow-releasing hydrogen sulfide donor GYY4137 induces epithelial-mesenchymal transition in A549 human lung adenocarcinoma cells	3
Bridging toxicological properties of environmental chemicals between animals and humans using healthy organoid systems	3
Differential effects of different time windows of postnatal perfluorooctane sulfonate exposure on cognitive development in mouse hippocampus	3
Effects of inhalation of multi-walled carbon nanotube (MWCNT) on respiratory syncytial virus (RSV) infection in mice	2
Differential response of SNU-1826 colon cells on the autophagy, ER stress, and inflammation during the regulation of microplastic internalization	2
Dihydropyrazine induces endoplasmic reticulum stress and inhibits autophagy in HepG2 human hepatoma cells	2
Early detection of hepatocarcinogens in rats by immunohistochemistry of γ-H2AX	2
Evaluation of rewarding effects of nitazene analogs: results from conditioned place preference tests and <i>in vivo</i> microdialysis experiments in mice	2
Development of an AI algorithm for the automatic detection and classification of rat bone marrow cells	2
Carcinogenicity of butyraldehyde in rats by a two-year inhalation study	2
Perinatal maternal exposure to high-dose sodium phenobarbital in the modified Comparative Thyroid Assay: no significant reduction in thyroid hormones in pups despite notable effects in dams	2
Construction and evaluation of an open-source database for inhalation-based physiologically based kinetic modeling of selected categories for industrial chemicals	2
Impact of variability of <i>in silico</i> and <i>in vitro</i> octanol/water partition coefficients of compounds on the input parameters and results of simplified human physiolo	2
Benzo(a)pyrene-induced mitochondrial respiration and glycolysis disturbance in human neuroblastoma cells	2
An investigation and assessment of the muscle damage and inflammation at injection site of aluminum-adjuvanted vaccines in guinea pigs	2
Lidocaine induces neurotoxicity in spinal cord neurons in Goto-Kakizaki rats via AMPK-mediated mitophagy	2
Effects of salt supplementation in uninephrectomized KK-Ay mice: Examining the potential of a diabetic kidney disease model	2
Retraction: MZF1 alleviates oxidative stress and apoptosis induced by rotenone in SH-SY5Y cells by promoting RBM3 transcription	2
Activator protein-1 mediates blue light-induced phototoxicity in retinal pigment epithelial cells	2
Ionic liquid cytotoxicity in mouse macrophage J774.1 cells: Effects of alkyl chain length, cation core, and anion type	2
Effects of early-life tosufloxacin tosilate hydrate administration on growth rate, neurobehavior, and gut microbiota at adulthood in male mice	2
Discovery and development of COVID-19 vaccines and therapeutics: nonclinical perspectives	2
2,3’,4,4’,5-Pentachlorobiphenyl induced thyroid dysfunction by increasing mitochondrial oxidative stress	2
Effects of perfluorooctane sulfonate (PFOS) on cognitive behavior and autophagy of male mice	2
miRNA-214-3p targets BNIP3 to affect autophagy and thus drive gastric cancer progression	2
Oxidative stress and cellular toxicity induced by dihydropyrazine: a comparative study with other Maillard reaction products	2
Cadmium induces chondroitin sulfate synthase 1 via protein kinase Cα and elongates chondroitin/dermatan sulfate chains in cultured vascular endothelial cells	2
A case of pulmonary edema due to guanfacine intoxication with measurement of serum guanfacine concentrations	2
Repeated administration of acrylamide for 28 days reduces late-stage progenitor cells and immature granule cells accompanying impaired neurite outgrowth in the adult hippocampal neurogenesis in young-	2
Pathogenesis of selective damage of granule cell layer in cerebellum of rats exposed to methylmercury	2
Determination of putrefactive amine and ammonia concentrations around decomposed corpses	2
Determination of human <i>F<sub>a</sub>F<sub>g</sub></i> of polyphenols using allometric scaling	2
Protection of cultured vascular endothelial cells against cadmium cytotoxicity by simultaneous treatment or pretreatment with manganese	2
Estimation of intravenous TTC (TTCiv) for Extractables and Leachables (E&Ls) by applying a modifying factor based on blood concentration predicted using an open-source PBPK model	2
Responses to antibiotics in human iPSC-derived neurons based on the clinical antibiotic-associated encephalopathy classification	2
Continuous infiltration of small peritoneal macrophages in the mouse peritoneum through CCR2-dependent and -independent routes during fibrosis and mesothelioma development induced by a multiwalled car	2
Alteration of bile acid composition is a possible risk factor for antibiotics-induced liver injury	2
Effects of microsampling on toxicity assessment of hematotoxic compounds in a general toxicity study in rats	2
Involvement of <i>Npas2</i> and <i>Per2</i> modifications in zinc-induced acute diurnal toxicity in mice	2
Preclinical <i>in vitro</i> evaluation of immune suppression induced by GYM329, Fc-engineered sweeping antibody	2
Transcriptome analysis of cultured human vascular endothelial cells after γ-ray irradiation and correlation analysis with ATP, ADP, and adenosine as secondary soluble factors	2
Fetal loss due to Th1-skewed Th1/Th2 balance with increase (not decrease) of regulatory T cells in abortion-prone mouse model	2
Reactive oxygen species (ROS) assay-based photosafety screening for complex ingredients: Modification of the ROS assay protocol	2
Establishment of an <i>in vitro</i> cholestasis risk assessment system using two-dimensional cultured HepaRG cells and 12 bile acids	2
Assessment of metabolic activation of felbamate in chimeric mice with humanized liver in combination with <i>in vitro</i> metabolic assays	2
Breast milk-mediated exposure to dioxins and antigen in infancy enhances antigen-specific antibody production capacity in adulthood in mice	2
Tributyltin activates the Keap1–Nrf2 pathway via a macroautophagy-independent reduction in Keap1	2