OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Toxicological Sciences is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Lack of human relevance for rat developmental toxicity of flumioxazin is revealed by comparative heme synthesis assay using embryonic erythroid cells derived from human and rat pluripotent stem cells	16
Long-term exposure to urban particulate matter exacerbates mortality after ischemic stroke in mice	15
Glasgow coma scale may be a predictive factor for delayed neurological sequelae after carbon monoxide poisoning: a retrospective analysis of a nationwide multicenter observational registry in Japan	14
Histological differences between the central and peripheral areas of the testes of busulfan-administered mice	10
Per- and polyfluoroalkyl substances: toxicokinetics, exposure and health risks	10
Acyl-CoA:diacylglycerol acyltransferase 1 inhibition in the small intestine increases plasma transaminase activity via the activation of protein kinase C pathway	9
Identification of apoptotic pathways in zearalenone-treated mouse sertoli cells	8
False-negative chemicals in ESR-based photosafety test (ESR-PT) and their significance for photosafety evaluations: examples of bithionol, fenticlor and cilnidipine	7
Cadmium inhibits forskolin-induced differentiation of human placental BeWo cells	7
Neuro-protective effects of n-butylphthalide on carbon monoxide poisoning rats by modulating IL-2, AKT and BCL-2	7
Activation of the arylhydrocarbon receptor through maternal beta-naphthoflavone exposure in the neonatal kidney	6
Oxidative stress-induced TET1 upregulation mediates active DNA demethylation in human gastric epithelial cells	6
Spatio-temporal distribution of reactive sulfur species during methylmercury exposure in the rat brain	6
Oxycodone alleviates LPS-induced neuroinflammation by regulating the CREB/miR-181c/PDCD4 axis	6
Human gut microbiota influences drug-metabolizing enzyme hepatic Cyp3a: A human flora-associated mice study	6
Diphenylarsinic acid induced astrocyte-preferential cell-type-specific aberrant activation of signal transduction related to oxidative stress, MAP kinase activation, transcription factor regulation, a	6
<i>In vivo</i> analysis of acute eletropharmacological effects of proton pump inhibitors using halothane-anesthetized dogs: a translational study of cardiovascular adverse events	5
Pharmacokinetics of tacrolimus following an overdose in a patient with extreme obesity and genotype <i>CYP3A53/3</i>: a case report	5
Male rat-specific fatty change in liver by DS-1971a: Elevation in phospholipids and adenosine as early responses to the fatty change in male rat-derived primary hepatocytes	5
Propofol improves ischemia reperfusion-induced liver fibrosis by regulating lncRNA HOXA11-AS	5
Development challenges for carcinogenicity risk assessments of topical drugs	5
Evaluation of circulating miR-216a and miR-217 as biomarkers of pancreatic damage in the L-arginine-induced acute pancreatitis mouse model	5
Comparison of the acceptable surface limits derived from the skin sensitization potency for workers and swab residue limits determined from the permitted daily exposure derived from the systemic effec	5
Effect of secondary particle size of nickel oxide nanoparticles on cytotoxicity in A549 cells	5
Cadmium mediates pyroptosis of human dermal lymphatic endothelial cells in a NLRP3 inflammasome-dependent manner	5

Screening and identification of differential metabolites in serum and urine of bamaxiang pigs bitten by <i>trimeresurus stejnegeri</i> based on UPLC-Q-TOF/MS metabolomics technology	5
Methylthioacetic acid, a derivative of aroma compounds from <i>Cucumis melo</i> var. <i>conomon</i> dose-dependently triggers differentiation and apoptosis of RCM-1 human color	5
Spatial localization of cadmium and metallothionein in the kidneys of mice at the early phase of cadmium accumulation	5
Investigation of additional suitable positive controls in the human Cell Line Activation Test	5
Dabrafenib stimulates autophagy in thyroid carcinoma cells via HMGB-1	5
Melatonin therapy reverses lead exposure-induced testicular damage in rats despite the lack of effect on serum testosterone levels	5
Constitutive expression of cytochrome P450 1B1 endows testicular Leydig cells with susceptibility to 7,12-dimethylbenzanthracene-induced cell death	5
Amelioration of lipopolysaccharides-induced impairment of fear memory acquisition by alpha-glycosyl isoquercitrin through suppression of neuroinflammation in rats	4
No obvious toxicological influences of 50 μL microsampling from rats administered phenacetin as a drug with hematological toxicity	4
Evaluation of neurotoxicity of anticancer drugs using nematode <i>Caenorhabditis elegans</i> as a model organism	4
Comparative study of susceptibility to methylmercury cytotoxicity in cell types composing rat peripheral nerves: a higher susceptibility of dorsal root ganglion neurons	4
<i>Drosophila melanogaster</i> as potential alternative animal model for evaluating acute inhalation toxicity	4
Triphenylbismuth dichloride inhibits human glyoxalase I and induces cytotoxicity in cultured cancer cell lines	4
Carcinogenicity and chronic toxicity of butyl methacrylate in rats and mice by a two-year inhalation study	4
Plasma membrane damage triggered by benzalkonium chloride and cetylpyridinium chloride induces G<sub>0</sub>/G<sub>1</sub> cell cycle arrest via Cdc6 reduction in human lung ep	4
Lipopolysaccharide administration increases the susceptibility of mitochondrial permeability transition pore opening via altering adenine nucleotide translocase conformation in the mouse liver	4
Potential of connexin 32 as a predictive marker for drug-induced cholestatic liver injury in a collagen vitrigel-culture model of HepG2-NIAS cells, a new subline of HepG2 cells, with bile canaliculus-	4
Establishment of hyperoxic cell culture system for predicting drug-induced liver injury: reducing accumulated lipids in hepatocytes derived from chimeric mice with humanized liver	4
Effects of microsampling on toxicity evaluation of 1-naphthylisothiocyanate (ANIT), a hepatotoxic substance, in a mouse toxicity study	4
Transcriptome analysis in various cell lines exposed to nitric oxide	4
Nafamostat mesylate sensitizes ovarian cancer cells to carboplatin by promoting the ZNF24-mediated inhibition of WNT2B	3
A physiologically based kinetic modeling of ethyl <i>tert</i>-butyl ether in humans–An illustrative application of quantitative structure-property relationship and Monte Carlo simulation	3
Comparative sensitivity of laboratory animals used for preclinical convulsion risk assessment to drug-induced convulsion	3
Dexmedetomidine attenuates acute stress-induced liver injury in rats by regulating the miR-34a-5p/ROS/JNK/p38 signaling pathway	3
Induction of systemic inflammation by welding fume exposure in office workers as well as welders in welding factories	3
Effects of food restriction on toxicological parameters in juvenile rats	3
Toxicological effects of Sb(III), Sb(V), and NMG-Sb(V) in human lung, kidney, and liver cells: cytotoxicity and fibrotic factor induction	3
Bridging toxicological properties of environmental chemicals between animals and humans using healthy organoid systems	3
Paternal methamphetamine exposure differentially affects first and second generations in mice	3
Impact of selenium content in fetal bovine serum on ferroptosis susceptibility and selenoprotein expression in cultured cells	3
Toxicokinetic evaluation during intoxication of psychotropic drugs using brain microdialysis in mice	3
Developing a GNN-based AI model to predict mitochondrial toxicity using the bagging method	3
Differential effects of different time windows of postnatal perfluorooctane sulfonate exposure on cognitive development in mouse hippocampus	3