Experimental Gerontology

Article	Citations
Editorial Board	155
Corrigendum to “Segmental extracellular-to-intracellular water resistance ratio and physical function in older adults” [Exp. Gerontol. 181 (2023) 112278]	132
Editorial Board	122
Overexpression of solute carrier family 6 member 12 promotes cell injury in Parkinson's disease via MAPK signaling pathway	92
Correlation between blood pressure and mortality in older critically ill patients: Insights from a large intensive care unit database	88
Anti-fibrosis effect and its mechanism of atractylenolide III on post-traumatic extending knee joint contracture in rats	80
Oral administration of liposome-encapsulated thymol could alleviate the inflammatory parameters in serum and hippocampus in a rat model of Alzheimer's disease	78
Aerobic exercise attenuates abnormal myelination and oligodendrocyte differentiation in 3xTg-AD mice	76
Impact of repetitive home-based galvanic vestibular stimulation on cognitive skills in healthy older adults	72
Inflammatory biomarkers of frailty: A review	66
Activation of α7nAChR by PNU282987 improves cognitive impairment through inhibiting oxidative stress and neuroinflammation in D-galactose induced aging via regulating α7nAChR/Nrf2/HO-1 signaling pathw	59
A pilot investigation of reliability and validity of balance and gait assessments using telehealth with healthy older adults	56
Comparative efficacy of exercise interventions for cognitive health in older adults: A network meta-analysis	49
Cognitive impairment: The missing link between sarcopenic obesity and functional decline	48
Effects of combined aerobic and resistance exercise on arterial stiffness in middle-aged and older men with dysglycemia and dyslipidemia: A 12-week intervention study	48
The effect of tamoxifen on the lipid profile in women: A systematic review and meta-analysis of randomized controlled trials	47
Effects of an inulin fiber diet on the gut microbiome, colon, and inflammatory biomarkers in aged mice	47
Enhancing fracture risk indication: The impact of bone load index and muscle fat infiltration on vertebral compression fracture	46
Segmental extracellular-to-intracellular water resistance ratio and physical function in older adults	45
The biological roots of the sex-frailty paradox	45
Comparison of metabolic risk factors, physical performances, and prevalence of low back pain among categories determined by visceral adipose tissue and trunk skeletal muscle mass in middle-aged men	44
Immunophenotypic characterization of B1a lymphocytes in Cuban older adults	43
Long-term administration of soft drink causes memory impairment and oxidative damage in adult and middle-aged rats	43
Oral frailty as a risk factor for mild cognitive impairment in community-dwelling older adults: Kashiwa study	43
Frequency and factors associated with sarcopenia prediction in adult and elderly patients hospitalized for COVID-19	43

High-intensity interval training reduces the induction of neutrophil extracellular traps in older men using live-neutrophil imaging as biosensor	42
Gait speed reference values in community-dwelling older adults – Cross-sectional analysis from the Rotterdam Study	41
The inflammatory profiling in a cohort of older patients suffering from cognitive decline and dementia	41
Receiving financial support and its association with late-age depression: The mediating role of social engagement	41
Age-related structural changes show that loss of fibers is not a significant contributor to muscle atrophy in old mice	41
Development and validation of a risk prediction model for frailty in older nappers	39
QKL injection ameliorates Alzheimer's disease-like pathology by regulating expression of RAGE	39
Age-specific in the relationship between diastolic blood pressure and the risk of cardiovascular disease: A cohort study of the UK Biobank	39
A chronic low dose of Δ9-tetrahydrocannabinol (3 mg / kg / 21 d) reorganizes the disturbed wound healing process and accelerates wound closure in old female mice	38
Recruitment evaluation of a gerotherapeutic randomized controlled trial testing alpha-ketoglutarate in biologically older, middle-aged adults (ABLE)	38
The promise of amplification assays for accurate early detection of α-synucleinopathies: A review	37
Relationship between serum uric acid and sarcopenia in geriatric heart failure patients with preserved ejection fraction	37
Associations between the timing of eating and weight-loss in calorically restricted healthy adults: Findings from the CALERIE study	37
Mediterranean diet and mitochondria: New findings	36
Identifying and validating the key regulatory transcription factor YY1 in the aging process of pancreatic beta cells based on bioinformatics	36
Exosomes: A promising therapeutic strategy for intervertebral disc degeneration	36
Study on correlation between perioperative cognitive function and nutritional status in elderly patients with gastric cancer	36
Editorial Board	35
Effects of home-based specific and comprehensive balance-training programs on balance and functional status in healthy older adults	35
Parental age at death is associated with age at first birth in offspring	33
Alzheimer's disease genes and proteins associated with resistance and aerobic training: An in silico analysis	33
Editorial Board	32
Drosophila melanogaster flies better know than us the nutrients they need: Let them choose	32
Linear and non-linear analyses of autonomic modulation in uncontrolled and controlled elderly resistant hypertensives	32
Voluntarily wheel running inhibits the growth of CRPC xenograft by inhibiting HMGB1 in mice	32
Forecasting prevalence and mortality of Alzheimer's disease using the partitioning models	32
A VO2peak prediction model in older adults' patients with Parkinson's disease	31
Metformin use and brain atrophy in nondemented elderly individuals with diabetes	30
Exploring age-related iron dysregulation: effects on longevity, body size, and behavior in C. elegans	29
The role of oxidative stress in the association between metabolic score for insulin resistance and stroke: evidence from two large population-based studies	29
The relationship between nutrition and depression in the life process: A mini-review	29
Metformin delays the decline in thermogenic function of brown adipose tissue in a mouse model of Hutchinson-Gilford progeria syndrome	28
The effects of raloxifene on endothelial function and Inflammation in Postmenopausal women: A Meta-analysis of randomized controlled trials	28
PGC-1α participates in regulating mitochondrial function in aged sarcopenia through effects on the Sestrin2-mediated mTORC1 pathway	28
Validity of the Korean triage and acuity scale in older patients compared to the adult group	28
Bioinformatics identification of potential biomarkers and therapeutic targets for ischemic stroke and vascular dementia	27
Editorial Board	27
Longitudinal association between cardiometabolic comorbidities and physical activity in middle aged and older adults living with HIV	27
Effects of functional and combined training on subsets of memory T cells and functional fitness of postmenopausal women: A randomized controlled trial	27
Differences in power and performance during sit-to-stand test and its relationships to functional measures in older adults with and without Parkinson's disease	26
Senolytic therapy increases replicative capacity by eliminating senescent endothelial cells	26
Network-based analysis identifies key regulatory transcription factors involved in skin aging	26
Multimodal and conventional resistance training interventions improve muscle function in older adults: Findings from the Training IMCT study	26
Integration of small needle knife in treating inflammatory factors, Th17 cell function, and magnetic resonance imaging evaluation in osteoporosis complicated by compression fractures in elderly patien	26
Effects of unstable resistance training combined with high-definition transcranial direct current stimulation on proprioception, balance and fall risks in the elderly: a randomized controlled trial st	25
Effects of metformin on serum miRNA expression and target gene regulation in prediabetic patients	25
Machine learning insights on activities of daily living disorders in Chinese older adults	25
Chronic inflammation and cognitive frailty in older adults: A narrative review	24
Effects of free versus restricted arm movements on postural control in normal and modified sensory conditions in young and older adults	24
Exercise training alters resting brain-derived neurotrophic factor concentration in older adults: A systematic review with meta-analysis of randomized-controlled trials	24

Association of body roundness index, serum α-Klotho and osteoarthritis: A nationwide population-based study of middle-aged and older adults	24
Milk kefir therapy improves the skeletal response to resistance exercise in rats submitted to glucocorticoid-induced osteoporosis	24
Poor sleep quality is associated with probable sarcopenia in community-dwelling older adults: Results from the longevity check-up (lookup) 8+	24
Brainstem auditory evoked potential in cognitive impairment in patients with type 2 diabetes mellitus	24
Influence of human gut microbiome on the healthy and the neurodegenerative aging	24
Gut microbiome, and immune cells mediated effect on depression: A two-step, two-sample Mendelian randomization analysis	23
Polypharmacy, physical activity, and sedentary time in older adults: A scoping review	23
MicroRNA-511-3p regulates Aβ1–40 induced decreased cell viability and serves as a candidate biomarker in Alzheimer's disease	23
The effect-modification of physical activity on the association of pain with impaired physical function in aging adults	23
The characteristics of the body mass frequency index in dysmobility syndrome: A pilot study	22
The influence of chronic knee pain and age on conditioned pain modulation and motor unit control	22
Editorial Board	22
The relationship between muscle strength and epicardial fat in healthy adults	22
Visuospatial cognition predicts performance on an obstructed vision obstacle walking task in older adults	21
Increased knee-extension strength and steps per day after a novel post-hospitalization rehabilitative program in older adults (65+): Secondary analyses of a randomized controlled single-blinded trial	21
Spermidine alleviates thymopoiesis defects and aging of the peripheral T-cell population in mice after radiation exposure	21
Very old adults show impaired fatigue resistance compared to old adults independently of sex during a knee-extensors isometric test	21
Association between METS-VF and sarcopenia among middle-aged and older adults in China: The first longitudinal evidence from CHARLS	21
Immunosenescence evaluation of peripheral blood lymphocyte subsets in 957 healthy adults from 20 to 95 years old	21
Mechanism associated with changes in male reproductive functions during ageing process	20
Brain health correlates of mobility-related confidence	20
Does excess body weight accelerate immune aging?	20
Differences in mitochondrial function between brain and heart of senile rats exposed to acute hypobaric hypoxia. Role of nitric oxide	20
Circulating microRNAs related to lipid metabolism and solid tissue maintenance and morphology associate with mortality in elderly twins	20
Association of leukocyte telomere length with perceived physical fatigability	20
Are assessment measures for components of the International Classification of Functioning, Disability and Health reproducible for use on pre-frail and frail older adults? A systematic review	20
Influence of sarcopenia on surgical efficacy and mortality of percutaneous kyphoplasty in the treatment of older adults with osteoporotic thoracolumbar fracture	19
Short-term exposure to a clinical dose of metformin increases skeletal muscle mitochondrial H2O2 emission and production in healthy, older adults: A randomized controlled trial	19
High-intensity interval training reduces blood pressure in older adults: A systematic review and meta-analysis	19
Extra Virgin Olive Oil consumption from Mild Cognitive Impairment patients attenuates oxidative and nitrative stress reflecting on the reduction of the PARP levels and DNA damage	19
Age-associated changes in the gut microbiome impact efficacy of tumor immunomodulatory treatments	19
SARC-F predicts poor motor function, quality of life, and prognosis in older patients with cardiovascular disease and cognitive impairment	19
Age- and sex-dependence of muscle quality: Influence of intramuscular non-contractile tissues	19
Changes in AMPK activity induces cellular senescence in human dental follicle cells	19
Effect of blood flow restriction combined with low-intensity training on the lower limbs muscle strength and function in older adults: A meta-analysis	18
Circadian rhythms and objective measures of physical activity among middle-aged and older adults in Taiwan	18
The effects of PPARγ inhibitor on bones and bone marrow fat in aged glucocorticoid-treated female rats	18
Editorial Board	18
The influence of ageism on the hallmarks of aging: Where age stigma and biology collide	18
Association between physical activity & sedentary time on frailty in adults with chronic kidney disease: Cross-sectional NHANES study	18
Association between sex steroid hormones and α-klotho: Results from the NHANES 2013-2016 and Mendelian randomization study	18
Association of back pain with major depressive disorder among older adults in six low- and middle-income countries: A cross-sectional study	17
Lack of association between serum myonectin levels and sarcopenia in older Asian adults	17
The visual control of locomotion when stepping onto moving surfaces: A comparison of younger and older adults	17
Dietary inflammatory index and its associations with cardiovascular diseases and cancer: Evidence form NHANES 2017–2018 and Mendelian randomization analysis	17
The effect of casein hydrolysate intake on cerebral neural regulation during cognitive tasks in the elderly	17
Identification of two patterns of mitochondrial DNA-copy number variation in postcentral gyrus during aging, influenced by body mass index and type 2 diabetes	17
The tissue factor expression on CD14++CD16-monocytes is a new markers in the Chinese Han older adult population with sepsis: A prospective study	17
Exploring the impact of interleukins on sarcopenia development: A systematic review and meta-analysis	17
Plasma levels of myokines and inflammatory markers are related with functional and respiratory performance in older adults with COPD and sarcopenia	17
The multi-tissue benefits of exercise on aging human physiology	17
P16INK4a deletion alleviates contrast-induced acute kidney injury by ameliorating renal cell apoptosis and suppressing inflammation and oxidative stress	16
Retraction notice to “LRE-MMF: A novel multi-modal fusion algorithm for detecting neurodegeneration in Parkinson's disease among the geriatric population” [Exp. Gerontol. 197 (2024) 112585]	16
Single nucleotide polymorphism SULT2A1 rs4149448 and genetic risk score as biomarkers of frailty and progression of chronic kidney disease	16
Editorial Board	16
No causal relationship between serum urate and neurodegenerative diseases: A Mendelian randomization study	16
Erythrocyte Zn concentration and antioxidant response after supplementation with Zn in a postmenopausal population. A double-blind randomized trial	16
Age-dependent down-regulation of orexin receptors in trigeminal nucleus caudalis correlated with attenuation of orexinergic analgesia in rats	16
Genetic analysis of comorbidities between osteoarthritis, sarcopenia, and osteoporosis	16
Epstein-Barr virus and the origin of frailty and fatigue: A two-sample multivariable bidirectional Mendelian randomization study	16
Mitochondrial dysfunction drives cellular senescence: Molecular mechanisms of inter-organelle communication	16
Cross-sectional and prospective associations between homocysteine and a frailty index: A post-hoc analysis of the multidomain Alzheimer's prevention trial (MAPT)	16
Mediterranean diet and structural neuroimaging biomarkers of Alzheimer's and cerebrovascular disease: A systematic review	16
Comparing the effects of different exercises on blood pressure and arterial stiffness in postmenopausal women: A systematic review and meta-analysis	16
Effect of developmental and adult diet composition on reproductive aging in Drosophila melanogaster	16
Kaempferol: Paving the path for advanced treatments in aging-related diseases	16
The role of chondrocyte senescence in osteoarthritis pathogenesis and therapeutic implications	15
Changes in primitive reflexes in older adults and their relationship to mental health indices: An experimental investigation	15
The association of sleep and cortical thickness in mild cognitive impairment	15
The association between low cognitive reserve and subjective memory complaints in functionally independent older women	15
The acute response of irisin to resistance and endurance exercise at both lower and higher intensities in healthy older adults	15
Equating conversion norms for the Mini-Mental State Examination and Montreal Cognitive Assessment in healthy subjects and patients with neurodegenerative disorders	15
Corrigendum to “Associations of daily steps and step intensity with peripheral arterial disease in Chinese community-dwelling older women” [Exp. Gerontol. 201 (2025) 112706]	15
Differences in acute neuromuscular response after single session of resistance exercise between young and older adults	15
Extended anesthesia exposure for abdominal and pelvic procedures in older adults with colorectal cancer: Associations with chart dementia diagnoses	15
High-fat diet attenuates vestibular and auditory dysfunction in aged mice via macrophage-mediated anti-inflammatory mechanisms	15
Cellular senescence and glaucoma	15
Age related gut microbiota regulates energy-related metabolism to influence natural aging phenotypes in the heart	15
Editorial Board	15
Coenzyme Q10 ameliorates aging-induced memory deficits via modulation of apoptosis, oxidative stress, and mitophagy in aged rats	15

Research hotspots and trends in animal experiments on mild cognitive impairment: A bibliometric analysis	15
Old age as a risk factor for liver diseases: Modern therapeutic approaches	15
Differences in prolonged walking intensity and duration between older people reporting difficulty, modifications or no difficulty in walking	15
Anthropometric indicators and cardiovascular diseases risk in pre-diabetic and diabetic adults: NHANES 1999–2018 cross-sectional analysis	15
Editorial Board	15
S1P lyase inhibition prevents lung injury following high pressure-controlled mechanical ventilation in aging mice	14
Peripheral double negative T: A look at senescent Cubans	14
Smaller grey matter volume in the central olfactory system in mild cognitive impairment	14
Corrigendum: “Tectoridin inhibits osteoclastogenesis and bone loss in a murine model of ovariectomy-induced osteoporosis” [Exp. Gerontol. 140: 2020; 111057. DOI:10.1016/j.exger.2020.111057]	14
Comparison of clinical characteristics and outcome measures of PCR-positive and PCR-negative patients diagnosed as COVID-19: Analyses focusing on the older adults	14
Osteocalcin inhibits myocyte aging through promotion of starvation-induced autophagy via IL-6/STAT3 signaling	14
Neutrophil-to-lymphocyte ratio in aging: Trends and clinical implications	14
Strength versus endurance trained master athletes: Contrasting neurophysiological adaptations	14
Effects of a prolonged diet regimen on autophagic function in rat islets with aging	14
Gender-specific association of SLC19A1 and MTHFR genetic polymorphism with oxidative stress biomarkers and plasma folate levels in older adults	14
Protective effects of GLHP from Gracilaria lemaneiformis against UVB-induced photodamage in human immortalized keratinocytes cells and BALB/c mice	14
VPS33B-dependent exosomes modulate cellular senescence of mesenchymal stem cells via an autocrine signaling pathway	14
Maresin1 ameliorates postoperative cognitive dysfunction in aged rats by potentially regulating the NF-κB pathway to inhibit astrocyte activation	14
Inflammaging: The ground for sarcopenia?	14
Experimental models for elderly patients with membranous nephropathy: Application and advancements	14
Parkinson's disease and microRNAs - Lessons from model organisms and human studies	14
Associations of non-exercise estimated cardiorespiratory fitness with mortality risk in individuals with diabetic kidney diseases: Analysis of 1999–2018 NHANES data	14
Editorial Board	14
Cognitive–exercise dual-task intervention ameliorates cognitive decline in natural aging rats through reducing oxidative stress and enhancing synaptic plasticity	14
Exogenous oxidative stressors elicit differing age and sex effects in Tigriopus californicus	14
Thigh muscles are more susceptible to age-related muscle loss when compared to lower leg and pelvic muscles	14
Decadal analysis of efficacy and safety profiles of mesenchymal stem cells from varied sources in knee osteoarthritis patients: A systematic review and network meta-analysis	14
Editorial Board	14
Difference between estimated GFR based on cystatin C versus creatinine and incident dementia, cognitive functions and biological aging: A cohort study of the UK Biobank	14
Mediating role of thyroid dysfunction in the relationship between insomnia and osteoporosis: A Mendelian randomization analysis	14
Exergaming interventions for older adults: The effect of game characteristics on gameplay	13
Older rats show slow modulation of hippocampal theta rhythm during voluntary running	13
Aging-dependent mitochondrial bioenergetic impairment in the skeletal muscle of NNT-deficient mice	13
The mechanisms and functions of TNF-α in intervertebral disc degeneration	13
DPP4 inhibitors as a potential therapeutic option for sarcopenia: A 6-month follow-up study in diabetic older patients	13
A bibliometric analysis of inflammation in sarcopenia from 2007 to 2022	13
Plasma volume variations in response to high intensity interval training in obese women: The influential role of menopausal status and age	13
Development and psychometric evaluation of the Polish version of the Chronic Pain Acceptance Questionnaire (CPAQ)	13
Lower extremity performance predicts length of hospital stay in older candidates to elective cardiac surgery	13
Recognition of mild cognitive impairment in older adults using a polynomial regression model based on prefrontal cortex hemoglobin oxygenation	13
Neurobiological and anti-aging benefits of yoga: A comprehensive review of recent advances in non-pharmacological therapy	13
Early life exercise impacts physiology and lifespan in a sex- and genotype-dependent manner in a Drosophila melanogaster exercise model	13
Progressive aerobic exercise in reducing inflammation and oxidative stress markers in older adult Korean women with obesity	13
D-chiro-inositol increases antioxidant capacity and longevity of Caenorhabditis elegans via activating Nrf-2/SKN-1 and FOXO/DAF-16	13
CHRNA1 induces sarcopenia through neuromuscular synaptic elimination	13
A prospective cohort study on the association between new falls and balancing ability among older adults over 80 years who are independent	13
Zhuyeqing liquor promotes longevity through enhancing stress resistance via regulation of SKN-1 and HSF-1 transcription factors in Caenorhabditis elegans	13
Unraveling the relationship between obstructive sleep apnea and osteoarthritis: A multivariate mendelian randomization highlighting the role of BMI as a confounding factor	13
Modifiable predictive factors and all-cause mortality in the non-hospitalized elderly population: An umbrella review of meta-analyses	12
High-throughput sequencing analysis of the characteristics of the gut microbiota in aged patients with sarcopenia	12
Respiratory training in older women: Unravelling central and peripheral hemodynamic slow oscillatory patterns	12
Analysis of the effectiveness of a computerized cognitive stimulation program designed from Occupational Therapy according to the level of cognitive reserve in older adults in Primary Care: Stratified	12
Social frailty increases the risk of all-cause mortality: A longitudinal analysis of the English Longitudinal Study of Ageing	12
Heterogeneity in resistance training-induced muscle strength responses is associated with training frequency and insulin resistance in postmenopausal women	12
Comparison of traditional vs. lighter load strength training on fat-free mass, strength, power and affective responses in middle and older-aged adults: A pilot randomized trial	12
Acute catabolic bone metabolism response to exercise in young and older adults: A narrative review	12
Diclofenac, a NSAID, delays fracture healing in aged mice	12
The guppy (Poecilia reticulata) is a useful model for analyzing age-dependent changes in metabolism, motor function, and gene expression	12
Predictors of total mortality and their differential association on premature or late mortality in the SUN cohort	12
No impact of combining multi-ingredient supplementation with exercise on body composition and physical performance, in healthy middle-aged and older adults: A systematic review and meta-analysis	12
Interaction of Klotho and sirtuins	12
25-hydroxyvitamin D insufficiency and inflammation increase cardiovascular risk in older people	12
Age-related morphological and functional changes in the small intestine of senescence-accelerated mouse	12
Visual-related training to improve balance and walking ability in older adults: A systematic review	12
ER stress in cardiac aging, a current view on the D-galactose model	11
Dose-response associations of accelerometer-measured physical activity with mortality across frailty levels: A prospective cohort study	11
Quantitative analysis of balance function characteristics in older patients with mild to moderate cognitive impairment	11
Editorial Board	11
Data-driven physical actigraphy patterns relate to cognitive and vascular health in older adults	11
Investigation of commonly used assessment methods for predicting fall risk in the elderly	11
Neuropsychological assessment in cognitively healthy nonagenarians and centenarians: an updated systematic review and meta-analysis	11
Baicalin alleviates intervertebral disc degeneration by inhibiting the p38 MAPK signaling pathway	11
Environmental enrichment modulates silent information regulator 1 (SIRT1) activity to attenuate central presbycusis in a rat model of normal aging	11
A novel insight into the key gene signature associated with the immune landscape in the progression of sarcopenia	11
Comparison of the surgical efficacy of robot-assisted and freehand nail placement in the treatment of sarcopenia combined with femoral neck fractures younger than 65 years	11
Association between arterial stiffness and walking capacity in older adults	11
Editorial Board	11
Factors related to trunk intramuscular adipose tissue content – A comparison of younger and older men	11
Visualizing the bibliometrics of the inflammatory mechanisms in intervertebral disc degeneration	11
The effect of tibolone treatment on fasting blood sugar, insulin, insulin resistance and endothelial function in postmenopausal women: A meta-analysis of randomized controlled trials	11
The triglyceride-glucose index mediates associations between dietary inflammation index/Composite Dietary Antioxidant Index and cardiovascular disease incidence: insights from NHANES study	11
Oral frailty is associated with mortality independently of physical and psychological frailty among older adults	11
Sarcopenic patients “get even”: The impact of COVID-19 vaccination on mortality	11
Decrease in force control among older adults under unpredictable conditions	11
Early cardiac aging linked to impaired stress-resistance and transcriptional control of stress response, quality control and mitochondrial pathways	11
Thyroid nodules and its association with vitamin D in centenarians	11
The effect of high intensity interval training with genistein supplementation on mitochondrial function in the heart tissue of elderly rats	11
Effect of healthy lifestyle score trajectory on all-cause mortality in the late middle-aged and older population: Finding from 17-year retrospective cohort study	11
The relationship between interhemispheric transfer time and physical activity as well as cardiorespiratory fitness in healthy older adults	11
Development and validation of an earphone-based system to measure short physical performance battery in older adults	11
l-Glutamine supplementation enhances glutathione peroxidase and paraoxonase-1 activities in HDL of exercising older individuals	11
The effect of early time-restricted eating on muscle damage-related biomarkers and anxiety in older men	11
Time-dependent relationships between exercise training-induced changes in nitric oxide production and hormone regulation	11
Contribution of impaired autophagy, mitochondrial dysfunction and abnormal lipolysis to epididymal aging in mice	11
Valsartan and sacubitril combination treatment enhances collagen production in older adult human skin cells	11