Cancer Investigation

Article	Citations
Clinical Characteristics and Impact on Prognosis of Melanoma Accompanied by Multiple Primary Malignancies: A Retrospective Analysis	107
Artificial Intelligence in Cancer Clinical Research: V. What We Have Learned About Human Intelligence from Artificial Intelligence	40
Effect of Androgen–Androgen Receptor Directed Therapy on COVID-19 Outcome in Prostate Cancer Patients	29
Use of Antiperspirant Products and Risk of Breast Cancer: A Meta-Analysis of Case-Control Studies	24
CTL-NK Signature Based on Immune Gene Profiling and IHC Predicts Clinical Outcomes in Triple-Negative Breast Cancer	23
Racial Diversity and Reporting in United States Food and Drug Administration Registration Trials for Thoracic Malignancies from 2006 to 2020	23
COVID-19 Outbreak Impact on Cancer Multidisciplinary Team Meetings. A Multicenter French Experience	22
Adverse Events Induced by Nivolumab Plus Ipilimumab vs. Nivolumab Monotherapy among Cancer Patients: A Systematic Review and Meta-Analysis	22
PARP Inhibitors Rising as an Epoch-Making Strategy in First-Line Maintenance Therapy of Ovarian Cancer: A Systematic Review and Meta-Analysis	20
Clinical Analysis of the Efficacy and Safety of Different Neoadjuvant Strategies in the Treatment of Locally Advanced Rectal Cancer	14
Clinical validation of a ctDNA-Based Assay for Multi-Cancer Detection: An Interim Report from a Vietnamese Longitudinal Prospective Cohort Study of 2795 Participants	13
Development and Validation of a Nomogram for Prognosis Prediction in Patients with Synchronous Primary Thyroid and Breast Cancer Based on SEER Database	13
Linking p53 rs1042522 Variant to Thyroid Cancer Risk: Insights from a Comprehensive Meta-Analysis of 2116 Cases	13
A Nomogram for Predicting Survival in Advanced Non-Small-Cell Lung Carcinoma Patients: A Population-Based Study	12
The Democratization of Hematology-Oncology Medical Education during the COVID-19 Pandemic	12
Decision Aids for Decision Making about Locally Advance Breast Cancer: A Systematic Review	12
Gene Expression Analysis of Early Stage Changes in Pancreatic Cancer by Kras G12D Transfer in Pancreatic Progenitor-	11
Long Non-Coding RNA and Chemoresistance in Bladder Cancer – A Mini Review	11
Correction	10
A Mechanistic Review of Methotrexate and Celecoxib as a Potential Metronomic Chemotherapy for Oral Squamous Cell Carcinoma	10
Clinical Validation of Local Versus Commercial Genomic Testing in Cancer: A Comparison of Tissue and Plasma Concordance	10
Determinants of Post-Traumatic Growth and Quality of Life in Ghanaian Breast Cancer Survivors	9
Clinical and Pathological Characteristics of the Mammary Paget’s Disease: A Single-Center Retrospective Study in Japan	9
The Relationship Between Body Image and Meaning of Life Among Women with Breast Cancer in Kerman, Iran	9
Immunomodulatory Effect of First-Line Cisplatin Versus Carboplatin in Response to Second-Line Nivolumab Therapy in Metastatic Non-Small Cell Lung Cancer	8

Perception, Cognition and Thought: Part I Nature, Evolution and Development of Conceptual and Symbolic Processes	8
Elevated Expression of LGR5 and WNT Signaling Factors in Neuroblastoma Cells With Acquired Drug Resistance	8
Webinar as an Informational Resource on Trastuzumab Biosimilars: Planning, Promotion, Execution, and Evaluation	7
Practice-Changing Trials in Gastrointestinal Cancers at ASCO 2025: A Critical Review and Clinical Context	7
Sepsis-related outcomes of patients with Philadelphia-negative myeloproliferative neoplasms	7
Comparative Evaluation of Serum Irisin Levels in Cancer Patients and Healthy Individuals: A Systematic Review and Meta-Analysis of Diagnostic Evidence	7
Assessing Chemotherapy-Induced Peripheral Neuropathy in Postmenopausal Breast Cancer Patients Using Vibration Perception Threshold	7
Dynamic Changes of Peripheral NK Cells Predict Outcome in Patients with PD-L1 Positive Non-small-cell Lung Cancer Undergoing Immune Checkpoint Inhibitors as Second-line Therapy	7
Stereotactic Body Radiation Therapy in the Management of Oligometastatic Uterine Cancer	7
Correction	6
Predictors of Acute Kidney Injury in Patients Prescribed Immune Checkpoint Inhibitor Therapy and Their Association with Death: A Systematic Review and Meta-Analysis	6
p53 Missense Mutation is Associated with Immune Cell PD-L1 Expression in Triple-Negative Breast Cancer	6
Tumoral Overexpression of Hepcidin is Associated with Poor Prognosis of Patients with Clear Cell Renal Cell Carcinoma	6
A Review on Emerging Techniques for Diagnosis of Colorectal Cancer	6
Analytical and Clinical Validation of a Target-Enhanced Whole Genome Sequencing-Based Comprehensive Genomic Profiling Test	6
Update on Pediatric Thyroid Cancer Incidence and Mortality Trends in the United States, 2000-2018	6
Efficacy and Safety of Different Dosages of Anlotinib Combined with PD-1 Monoclonal Antibody in the Treatment of Advanced Non-Small Cell Lung Cancer	6
Early Changes in Lymphocyte/Monocyte Ratio on Treatment as a Prognostic Marker to Predict Overall Survival in Patients with Advanced Cancer Treated with Immune Checkpoint Inhibitors	6
An Overview of Cancer Biology, Pathophysiological Development and It’s Treatment Modalities: Current Challenges of Cancer anti-Angiogenic Therapy	6
Research Progress of Nutrition and Coagulation-Based Markers as Predictors for Digestive System Cancers	6
Integrative Analysis Developing and Validating Potential Candidate Biomarkers for Cancer Stemness Features of Pan-Renal Cell Carcinoma	6
Turning the Tables: How Encorafenib and Binimetinib are Reshaping NSCLC Treatment	5
Fusobacterium Detected in Barrett’s Esophagus and Esophageal Adenocarcinoma Tissues	5
Evaluation of High-Dimensional Data Classification for Skin Malignancy Detection Using DL-Based Techniques	5
Capecitabine-Enhanced Brachytherapy in Locally Advanced Cervical Cancer: A Phase II Non-Randomized Trial on Safety and Efficacy	5
Retrospective Analyses of PD-L1, LAG-3, TIM-3, OX40L Expressions and MSI Status in Gastroenteropancreatic Neuroendocrine Neoplasms	5
Curcumin Enhances the Efficacy of Docetaxel by Promoting Anti-Tumor Immune Response in Head and Neck Squamous Cell Carcinoma	5
Differential Toxicity of Immune Checkpoint Inhibitors in Older Adults: A Large-Scale, Propensity Score-Matched Real-World Analysis	5
The Nature, Origin and Evolution of Life: Part II The Origin of Life	5
Neoadjuvant Therapy and Axillary Lymph Node Status in HER2-Positive Breast Cancer	5
Human Mycobiota and Its Role in Cancer Progression, Diagnostics and Therapeutics: A Link Lesser-Known	4
Advanced Machine Learning and Multiomics Reveal Tumor Dynamics and Therapeutic Opportunities in Glioblastoma Multiforme	4
Risk Factors and Epidemiological Trends (1990–2021) in Esophageal Cancer Across East and South Asia	4
Perceptions of COVID-19 Vaccination in Patients with Genitourinary Cancers: Correspondence	4
Glucose Metabolism and Glucose Transporters in Head and Neck Squamous Cell Carcinoma	4
Recurrence Patterns and Clinical Management after a Positive Sentinel Node Biopsy in Melanoma Patients	4
Metagenomic Analysis of Biliary Microbial Flora in Patients with Gallbladder Cancer or Gallstones-Associated Chronic Cholecystitis	4
Cancer Inducing Role of BK Polyomavirus Large T Antigen: Molecular Signaling View	4
Efficacy and Safety of First-Line Platinum-Based Doublet Chemotherapy in Advanced Primary Pulmonary Salivary Gland Tumors (PSGTs)	4
Fear of Cancer Recurrence and COVID-19 Anxiety Among Cancer Survivors: A Cross-Sectional Study in Southeast Iran	4
Telomere Shortening of Barrett’s Esophagus and Esophageal Adenocarcinoma in Japanese Patients	4
Immunomodulation of the Breast Cancer Microenvironment by Tumor-Derived Exosomes: Implications for Immunotherapy	4
Interplay Between ERK1/2 Signaling Pathway and Estradiol Receptor Modulates ER Targeted Genes Involved in Progression of Estrogen Responsive Breast Cancers	4
Real World Presentation and Treatment Outcomes with a Predominant Induction Chemotherapy Based Approach in Nasopharyngeal Carcinoma: A Sixteen Year Report from a Teaching Hospital in India	4
Perceptions of COVID-19 Vaccination in Patients with Genitourinary Cancers: A Survey Study	4
TTYH3 Promotes Cervical Cancer Progression by Activating the Wnt/ β -Catenin Signaling Pathway	4
Ethical Principles in the Analysis of Prostate Cancer Diagnostics	3
Increased Risk of Hyperglycemia in Advanced Urothelial Cancer Patients Treated with Enfortumab Vedotin: A Systematic Review and Meta-Analysis	3
Beyond the Horizon: A Cutting-Edge Review of the Latest Checkpoint Inhibitors in Cancer Treatment	3
The Prognostic Value of ADAMTS8 and Its Role as a Tumor Suppressor in Breast Cancer	3

Microvessel Density (MVD) in Patients with Osteosarcoma: A Systematic Review and Meta-Analysis	3
The Impact of Prophylactic Post-Chemotherapy G-CSF on the Relapse Rates in Patients with Acute Myeloid Leukemia: A Meta-Analysis	3
Radiation Therapy for Primary Cutaneous Gamma Delta Lymphoma Prior to Stem Cell Transplantation	3
Magnetic Resonance Imaging Guided Prostate Biopsy in Patients with ≥ One Negative Systematic Transrectal Ultrasound-Guided Biopsy: A Systemic Review and Meta-Analysis	3
Barthel Index and Age as Predictors of Discharge Destination in Patients with Glioblastoma	3
Gender, Bladder Cancer Healthcare and Burden of COVID-19	3
Identifying Optimal Candidates for Primary Tumor Resection Among Metastatic Pancreatic Cancer Patients: A Population-Based Predictive Model	3
A Comprehensive Insight into Apoptosis: Molecular Mechanisms, Signaling Pathways, and Modulating Therapeutics	3
Role of the Family in Treatment Decision-Making for Women with Breast Cancer: a Study from China	3
A Systematic Review of the Efficacy of KRAS p.G12C Inhibitors in Metastatic Colorectal Cancer: The Current State of Science	3
Suspension of Oncology Randomized Clinical Trials during the COVID-19 Pandemic: A Cross-Sectional Evaluation of COVID-Related Suspensions	3
Perineural Invasion as a Predictive Biomarker of Groin Metastases and Survival Outcomes in Vulvar Cancer: A Meta-Analysis	3
Modified Le-Net Model with Multiple Image Features for Skin Cancer Detection	3
Chemotherapy-Induced Oral Complications and Prophylaxis Strategies	3
Does Aspirin Use Reduce the Risk for Ovarian Cancer?	3
Correction	3
Evidence-Based Medicine and Complementary and Alternative Medicine – Attitudes and Knowledge of German Medical Students	3
Comparative Analysis of miRNA and EMT Markers in Metastatic Colorectal Cancer	3
Trends and Projections of Stomach Cancer Incidence in Hong Kong: A Population-Based Study	3
A Systematic Review of the Treatment Outcomes among Prostate Cancer Patients in Africa	3
Cognitive Dysfunction in Non-CNS Metastatic Cancer: Comparing Brain Metastasis, Non-CNS Metastasis, and Healthy Controls	3
Outcomes of Cancer Patients with COVID-19: The Virginia Commonwealth University Experience	3
Research Progress on CARM1 and its Relationship with Colorectal Cancer	3
Artificial intelligence in Cancer Clinical Research: IV. Inherent Limitations of Artificial Intelligence	3
Vitamin D Receptor Expression Is Significantly Decreased in Bone Metastases Compared to Matched Primary Breast Cancer Tumours	3
Flamingo Search Sailfish Optimizer Based SqueezeNet for Detection of Breast Cancer Using MRI Images	3
Evaluation of Impression Cytology for Diagnosis of Ocular Surface Squamous Neoplasia in Two Kenyan Tertiary Hospitals	3
Comorbidity in Small Cell Lung Cancer: Prognostic Impacts of Hypertension/Coronary Artery Disease, Diabetes Mellitus, and Chronic Obstructive Pulmonary Disease	3
TTN Mutation in Endometrial Endometrioid Carcinoma Is Associated with Poor Clinical Outcomes and High Tumor Mutation Burden	2
Thyroid Cancer Detection Using Py-SpinalNet: A Pyramid and SpinalNet Approach	2
Resilience, Social Support, and Anxious Preoccupation in Patients with Advanced Cancer during COVID-19 Pandemic	2
Significance and Implications of Prostate Cancer: Critical Overview for Future Directions in Africa	2
Optimizing Diagnostic Tools & Outcomes Evaluation for t (9;22)-Positive Leukemias in Pediatric Low Middle-Income Country (LMIC) Patients	2
Breast Cancer Detection in Mammography Images Using Transfer Learning Model	2
Professional Challenges for United States Hematology/Oncology Trainees during COVID-19	2
The Influence of GLP-1 Receptor Agonists on Five-Year Mortality in Colon Cancer Patients	2
Enhancing Chemotherapy Adherence in Cancer Management: A Quasi-Experimental Trial of a Smartphone Application	2
CHEK2 Germline Variants and Their Clinical Implications: Experience from a Turkish Hereditary Cancer Cohort	2
Investigating Breast Cancer Detection with Contextual Relationship Embedded CNN in Mammograms	2
Post-Marketing Safety of Tazemetostat in Antitumor Therapy: A Real-World Pharmacovigilance Study of the FDA Adverse Event Reporting System	2
Integrated Analysis of Slow Transit Constipation and Colorectal Cancer Reveals the Co-Pathogenic Targets and Their Potential Clinical Value	2
Construction and Validation of a Prognostic Survival Prediction Model for NMIBC Patients Undergoing Radical Cystectomy	2
Impacts of Perioperative Comprehensive Nursing Intervention on Postoperative Urinary Incontinence and Quality of Life of Patients Undergoing Laparoscopic Radical Prostatectomy	2
Low Cancer Screening Rates Among Emergency Department Patients: A Multicenter Retrospective Study	2
The Pittsburgh Sleep Quality Index (PSQI) Applied to Cancer Patients: Psychometric Properties and Factors Affecting Sleep Quality	2
Where the Sidewalk Ends: Parenting as a Trainee during COVID-19	2
Next-Generation Salivary Biomarkers for Oral Cancer: From Noninvasive Diagnostics to Public Health Impact	2
Less is More? First Impressions From COSMIC-313	2
Elevated Vitamin B12, Risk of Cancer, and Mortality: A Systematic Review	2
LDHB Mediates Histone Lactylation to Activate PD-L1 and Promote Ovarian Cancer Immune Escape	2
Variation of Plasma Damage-Associated Molecular Patterns in Patients with Advanced Solid Tumors after Standard of Care Systemic Treatment	2
Prognostic Significance of Combining Cytokeratin-19, E-Cadherin and Ki-67 Analysis in Triple-Negative Breast Cancer with Basal-Like and Non-Basal-Like Phenotype	2
The Nature, Origin, and Evolution of Life: Part V Bringing It Together: Concepts, Constraints, and Closure	1
The Effect of Hand Massage on Quality of Life After Mastectomy: A Randomized Controlled Trial	1
Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Concurrent Use of Crocin During Chemoradiation for Esophageal Squamous Cell Carcinoma	1
Spine Instability Neoplastic Score (SINS) as a Predictive Tool in Conventional Radiotherapy: A Narrative Review	1
Tandem Dual CAR-T Cells Targeting HER2 and Mesothelin Enhance anti-Tumor Effects in Pancreatic Cancer	1
The Markers Auxiliary in Differential Diagnosis of Early Melanomas and Benign Nevi Sharing Some Similar Features Potentially Leading to Misdiagnosis – A Review of Immunohistochemical Studies	1
Impact of the Multidisciplinary Cancer Team on the Diagnostic and Therapeutic Care Pathway of Early Breast Cancer Patients and Perception of Team Members: The Experience of a Cancer Centre in Italy	1
Exercise interventions to combat cancer-related fatigue in cancer patients undergoing treatment: a review	1
Decoding Cervical Cancer Biomarkers: An Integrated Framework of Bioinformatics, Machine Learning, and Experimental Confirmation	1
The Influence of Body Mass Index on Treatment Response and Survival in HER2-Positive Breast Cancer Patients	1
Management of Non-Small Cell Lung Cancer: Updates from the European Lung Cancer Congress 2022	1
Next-Generation Therapies for Meningioma: Overcoming Barriers and Expanding Treatment Options	1
Self-Supervised Learning Method for Breast Cancer Detection with Image Feature Set and Modified U-Net Segmentation Using Whole Slide Image	1
Drug Repurposing Analysis for Colorectal Cancer through Network Medicine Framework: Novel Candidate Drugs and Small Molecules	1
Once-a-Week Ablative Radiotherapy as Replacement of Prolonged Fractionation in Frail Patients: Feasibility and Toxicity Results	1
The Roles of MicroRNA in Pancreatic Cancer Progression	1
The Journey of Resveratrol from Vineyards to Clinics	1
Poorly Controlled Diabetes Mellitus Increases the Risk of Deaths and Castration-Resistance in Locally Advanced Prostate Cancer Patients	1
Prognostic Value of Neutrophil-to-Lymphocyte Ratio and Tumor-Infiltrating Lymphocytes (TILs), for Patients with Triple-Negative Breast Cancer	1
Tertiary Lymphoid Structures, Immune Response, and Prognostic Relevance in Non-Small Cell Lung Cancer	1
Efficacy of Adjuvant First-Generation TKIs versus Chemotherapy in Patients with Completely Resected EGFR-Mutant Non-Small Cell Lung Cancer: A Meta-Analysis	1
A 15-Inflammation-Related Gene Signature Predicts the Prognosis of Patients With Pancreatic Ductal Adenocarcinoma	1
Accuracy of the ‘CUT’ Score for Assessing Malignancy in Bethesda 3 and 4 Thyroid Nodules in North American Population: A Retrospective Study	1
Ulceration vs. Mitosis in Cutaneous Melanoma: Which Is Superior for Predicting Prognosis Across Clinical Stages?	1
Anxiety, Depression, and Coping Strategies during Chemotherapy Treatment: A Comparison of Older and Younger Adults with Advanced Cancer in Brazil	1
Lung Cancer Treatment Advances in 2022	1
Clinical Characteristics and Prognostic Factors of Renal Sarcoma: A Japanese National Cancer Registry Study	1
Comparative Analysis of the Chemotherapy-Related Cognitive Impairments in Patients with Breast Cancer: A Community-Based Research	1

Development of a Novel Prognostic Model for Esophageal Squamous Cell Carcinoma: Insights into Immune Cell Interactions and Drug Sensitivity	1
Identification and Validation of a Prognostic Risk-Scoring Model Based on LATS2 Expression in Acute Myeloid Leukemia	1
Predictive Modeling of Long-Term Prognosis After Resection in Typical Pulmonary Carcinoid: A Machine Learning Perspective	1
Grade 4 Neutropenia Frequency as a Binary Risk Predictor for Adverse Clinical Consequences of Chemotherapy‑Induced Neutropenia: A Meta-analysis	1
Clinical Characteristics and Outcomes of COVID-19 in 1294 New Cancer Patients: Single-Center, Prospective Cohort Study from Iran	1
Clinical Challenges and Evolving Treatments in Desmoid Fibromatosis: A Single Institution Experience	1
Artificial Intelligence in Cancer Clinical Research: II. Development and Validation of Clinical Prediction Models	1
Examining the Direct and Indirect Effects of Socioeconomic Status on Colorectal Cancer Using Structural Equation Modeling	1
Efficacy and Safety of Current Treatment Regimens for Acute Myeloid Leukemia in Elderly Patients	1
Gustative Roussy Immune Score is a Predictor for Major Pathological Response in Rectal Cancer: A Result from the Preoperative Intraarterial Chemoembolization Combined with Radiotherapy (PCAR) Study	1
The Neutrophil-to-Lymphocyte Ratio May be the Best Serological Biomarker in Predicting Longer Survival in Neoadjuvant Treatment of Triple-Negative Breast Cancer	1
Multi-Modal Lung Cancer Detection Using Pyramidal Cascade Neuro-Fuzzy Fractional Network	1
Attenuated Total Reflection-Fourier Transform Infrared (ATR-FTIR) Spectroscopy Analysis of Saliva as a Diagnostic Specimen for Rapid Classification of Oral Squamous Cell Carcinoma Using Chemometrics M	1
Routine Skin Cancer Screening: Balance between Overdiagnosis and Prevention	1
Viral Hepatitis in Western Patients with Advanced Intrahepatic Cholangiocarcinoma: Retrospective Assessment of Prevalence, Prognostic and Predictive Significance	1
Genomic Alterations of Signaling and DNA Damage Repair Pathways in Non-Muscle Invasive Bladder Cancer	1
Sucrose Nonfermenting-Related Kinase Expression Is Related to a Metabolic Switch in Ovarian Cancer Cells That Results in Increased Fatty Acid Oxidation	1
Metabolism-Related Programmed Cell Death: Unveiling Prognostic Biomarkers, Immune Checkpoints, and Therapeutic Strategies in Ovarian Cancer	1
Cancer Stem Cells Promote Tumorigenesis and Progression of Pancreatic Cancer Through Notch-1 Pathway	1
Conceptualization of Breast Cancer and Attitudes toward Breast Cancer Screening: A Qualitative Study on Iranian and Australian Women	1
The Impact and Evaluation of Immune Checkpoint Inhibitors on Clinical Survival in Patients with Advanced Osteosarcoma: A Systematic Review and Meta-Analysis	1
Evaluation of the Efficacy of Postoperative Adjuvant Therapy for HER2-Positive Ductal Carcinoma in Situ with Microinvasion	1
Biomarker Potential of DNA Repair Genes XRCC1, XRCC3 and RAD51 Polymorphisms in Ovarian Cancer Patients	1
AURKA Enhances Antitumor Immunity by Activating CD4+ T Cell Proliferation in Colorectal Cancer	1
Veliparib‑Induced Toxicity in Cancer Patients: A Systematic Review and Meta‑Analysis	1
Combination Hormonal Drug Therapy Inhibits In Vitro Growth of Adult Ovarian Granulosa Tumor Cells	1