OOIR: Observatory of International Research

Papers

(The median citation count of Critical Reviews in Biotechnology is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Advances in the development of phage-mediated cyanobacterial cell lysis	159
Elucidation of transfer RNAs as stress regulating agents and the experimental strategies to conceive the functional role of tRNA-derived fragments in plants	100
Overview of resveratrol properties, applications, and advances in microbial precision fermentation	98
Wastewater-borne viruses and bacteria, surveillance and biosensors at the interface of academia and field deployment	72
Unveiling the potential of dendrobine: insights into bioproduction, bioactivities, safety, circular economy, and future prospects	69
Electrospun wound dressings with antibacterial function: a critical review of plant extract and essential oil incorporation	68
Bioreactor configurations for adventitious root culture: recent advances toward the commercial production of specialized metabolites	65
Plant lipid phosphate phosphatases: current advances and future outlooks	57
Sustainability of biodegradable plastics: a review on social, economic, and environmental factors	57
Smart reprograming of plants against salinity stress using modern biotechnological tools	53
Recent updates on green synthesis of lignin nanoparticle and its potential applications in modern biotechnology	53
Sustainable utilization of fruit and vegetable waste bioresources for bioplastics production	53
Enzyme hybrid nanoflowers and enzyme@metal–organic frameworks composites: fascinating hybrid nanobiocatalysts	51
Neurodegenerative disorders management: state-of-art and prospects of nano-biotechnology	49
Fermentation strategies to improve propionic acid production withpropionibacteriumssp.: a review	49
Advances in the metabolic engineering of Saccharomyces cerevisiae and Yarrowia lipolytica for the production of β	47
An update on experimental to large-scale production of bacteriophages against superbugs: a review	45
Production and waste treatment of polyesters: application of bioresources and biotechniques	43
Advances in high-throughput screening approaches for biosurfactants: current trends, bottlenecks and perspectives	43
Bacterial genome reduction for optimal chassis of synthetic biology: a review	42
Recent development of phenyllactic acid: physicochemical properties, biotechnological production strategies and applications	41
Biomaterials for eco-friendly packaging in dairy products: towards a cleaner, greener, and sustainable future	41
Synthetic biology for the food industry: advances and challenges	40
Role of proteins in the biosynthesis and functioning of metallic nanoparticles	40
Biofilm formation in xenobiotic-degrading microorganisms	40

3D printing: trends and approaches toward achieving long-term sustainability in the food industry	39
Enhancing plastic biodegradation process: strategies and opportunities	38
Antimicrobials from endophytes as novel therapeutics to counter drug-resistant pathogens	36
Perfusion culture of Chinese Hamster Ovary cells for bioprocessing applications	35
Diversity of fungus-mediated synthesis of gold nanoparticles: properties, mechanisms, challenges, and solving methods	34
Calcium-dependent protein kinase (CDPK/CPK)-mediated salicylic acid cascade: the key arsenal of plants under pathogens attack	33
Cold-active enzymes from deep marine psychrophiles: harnessing their potential in enhanced food production and sustainability	33
A crosswalk on the genetic and conventional strategies for enhancing astaxanthin production in Haematococcus pluvialis	32
A close-up of regulatory networks and signaling pathways of MKK5 in biotic and abiotic stresses	31
Proteomics for abiotic stresses in legumes: present status and future directions	31
Current trends in solid tannery waste management	29
Harnessing microbial division of labor for biomanufacturing: a review of laboratory and formal modeling approaches	29
Whole recombinant yeast-based vaccines: concept, importance, issues, and future scope	29
Advances in sustainable approaches utilizing orange peel waste to produce highly value-added bioproducts	29
Pluripotent stem cells for skeletal tissue engineering	28
Synergetic anaerobic digestion of food waste for enhanced production of biogas and value-added products: strategies, challenges, and techno-economic analysis	27
Unveiling the silent defenders: mycobacterial stress sensors at the forefront to combat tuberculosis	27
Sustainable and biotechnological production of docosahexaenoic acid from marine protists and slaughterhouse waste	27
Improving environmental stress resilience in crops by genome editing: insights from extremophile plants	27
Critical analysis of analytical techniques developed for statins in biological fluids, environmental and fermentation samples	27
Field and laboratory guidelines for reliable bioinformatic and statistical analysis of bacterial shotgun metagenomic data	27
Available strategies for improving the biosynthesis of surfactin: a review	27
Recent trends in nanomaterial-based signal amplification in electrochemical aptasensors	25
A story of two kingdoms: unravelling the intricacies of protein phase separation in plants and animals	25
Systems seed biology to understand and manipulate rice grain quality and nutrition	25
D-allulose 3-epimerase for low-calorie D-allulose synthesis: microbial production, characterization, and applications	24
Crucial aspects of metabolism and cell biology relating to industrial production and processing of Saccharomyces biomass	24
Catalytic mechanisms underlying fungal fatty acid desaturases activities	24
Molecular modification and biotechnological applications of microbial aspartic proteases	23
New strategies to study in depth the metabolic mechanism of astaxanthin biosynthesis in Phaffia rhodozyma	23
A comprehensive review on tissue culture studies and secondary metabolite production in Bacopa monnieri L. Pennell: a nootropic plant	22
Research progress on the application of cell-free synthesis systems for enzymatic processes	22
Amplification-free nucleic acids detection with next-generation CRISPR/dx systems	21
Nanobiosensors and their role in detection of adulterants and contaminants in food products	20
Fashion meets science: how advanced breeding approaches could revolutionize the textile industry	20
Membrane bioreactors for syngas permeation and fermentation	20
Value-added biotransformation of agricultural byproducts by cellulolytic fungi: a review	20
Microbial cell factories using Paenibacillus : status and perspectives	20
Strategies to improve the efficiency and quality of mutant breeding using heavy-ion beam irradiation	20
Thraustochytrids as a promising source of fatty acids, carotenoids, and sterols: bioactive compound biosynthesis, and modern biotechnology	20
Microbial production of vitamin B5: current status and prospects	19
Microbial alchemy: upcycling of brewery spent grains into high-value products through fermentation	19
APETALA2/ethylene-responsive factors in higher plant and their roles in regulation of plant stress response	19
Emerging trends in high-solids enzymatic saccharification of lignocellulosic feedstocks for developing an efficient and industrially deployable sugar platform	19
How do probiotics alleviate constipation? A narrative review of mechanisms	19
Chinese cordyceps products, geographic traceability and authenticity assessment: current status, challenges, and future directions	18
Engineering industrial yeast for improved tolerance and robustness	18
Harnessing the advances of genetic engineering in microalgae for the production of cannabinoids	18
Extension characteristics of TdT and its application in biosensors	18
Emerging alternative food protein sources: production process, quality parameters, and safety point of view	18

Cyanobacterial myxoxanthophylls: biotechnological interventions and biological implications	18
Efficient heterologous expression of cytochrome P450 enzymes in microorganisms for the biosynthesis of natural products	18
Progress of metabolic engineering for the production of eicosapentaenoic acid	17
Emerging green cell disruption techniques to obtain valuable compounds from macro and microalgae: a review	17
Metabolic engineering of Saccharomyces cerevisiae for the synthesis of valuable chemicals	17
Glycosylation of cellulase: a novel strategy for improving cellulase	17
Bioactive compounds from Cordyceps and their therapeutic potential	17
Microbial granules on reactors performance during organic butyrate digestion: clean production	16
Molecular prospective on the wheat grain development	16
Deciphering the role of miRNA in reprogramming plant responses to drought stress	16
Au-courant and novel technologies for efficient doubled haploid development in barley (Hordeum vulgare L.)	16
Sustainable management of tea wastes: resource recovery and conversion techniques	15
Iridoid glycosides from Picrorhiza genus endemic to the Himalayan region: phytochemistry, biosynthesis, pharmacological potential and biotechnological intercessions to b	15
Algae: the game-changers in biohydrogen sector	15
A comprehensive review on the recent advances for 5-aminolevulinic acid production by the engineered bacteria	15
Current trends and possibilities of typical microbial protein production approaches: a review	15
Bacteriophages: a potential game changer in food processing industry	15
Upcoming generation nanoengineered antimicrobial delivery system for targeting multidrug-resistant microbes	15
Insights in detection and analysis of organophosphates using organophosphorus acid anhydrolases (OPAA) enzyme-based biosensors	15
Potato microtuberization: its regulation and applications	15
Pilot scale polyhydroxyalkanoates biopolymer production using pure cultures: current status and future opportunities	15
Microbial torularhodin – a comprehensive review	14
Developed and emerging 1,4-butanediol commercial production strategies: forecasting the current status and future possibility	14
Ultrasonic processing: effects on the physicochemical and microbiological aspects of dairy products	14
Insight into recent advances in microalgae biogranulation in wastewater treatment	14
Strategies for modulating transglycosylation activity, substrate specificity, and product polymerization degree of engineered transglycosylases	14
Modern approaches to engineering human reporter cell lines using CRISPR within Safe Harbor loci and endogenous genes	13
Engineering traits through CRISPR/cas genome editing in woody species to improve forest diversity and yield	13
Rhodococcus: sequences of genetic parts, analysis of their functionality, and development prospects as a molecular biology platform	13
Oligonucleotide probes for imaging and diagnosis of bacterial infections	13
Advances in AI-based strategies and tools to facilitate natural product and drug development	13
Antiviral and antibacterial properties of phloroglucinols: a review on naturally occurring and (semi)synthetic derivatives with potential therapeutic interest	13
Microbial bioprocess performance in nanoparticle-mediated composting	13
Transcriptional control in microalgae: co-regulated fatty acid biosynthesis and carbon dioxide fixation	13
Advances in biological production of acetoin: a comprehensive overview	13
Intracellular biosensor-based dynamic regulation to manipulate gene expression at the spatiotemporal level	12
Microbial assisted multifaceted amelioration processes of heavy-metal remediation: a clean perspective toward sustainable and greener future	12
Advanced diagnostic methods for identification of bacterial foodborne pathogens: contemporary and upcoming challenges	12
The challenges of using NAD⁺-dependent formate dehydrogenases for CO₂conversion	12
Biological production of nicotinamide mononucleotide: a review	12
Chitin and chitosan from shellfish waste and their applications in agriculture and biotechnology industries	12
Astaxanthin biosynthesis for functional food development and space missions	11
Immobilized enzyme for screening and identification of anti-diabetic components from natural products by ligand fishing	11
Enzyme producing insect gut microbes: an unexplored biotechnological aspect	11
Strategies for tailoring pH performances of glycoside hydrolases	11
Recent advances and prospects of Bacillus amyloliquefaciens as microbial cell factories: from rational design to industrial applications	11
Current evidence in high throughput ultrafiltration toward the purification of monoclonal antibodies (mAbs) and biotechnological protein-type molecules	11
Response mechanisms to acid stress of acid-resistant bacteria and biotechnological applications in the food industry	10
Enzymes and pathways in microbial production of 2,3-butanediol and 3-acetoin isomers	10
Use of elicitors to enhance or activate the antibiotic production in streptomyces	10
An overview on fermentation strategies to overcome lignocellulosic inhibitors in second-generation ethanol production using cell immobilization	10
High-throughput genetic engineering tools for regulating gene expression in a microbial cell factory	10
Graphene as a nano-delivery vehicle in agriculture – current knowledge and future prospects	10
Every road leads to Rome: diverse biosynthetic regulation of plant cell wall-degrading enzymes in filamentous fungi Penicillium oxalicum and Trichoderma r	10
Plant response to silver nanoparticles: a critical review	10
Synthesis of C–N bonds by nicotinamide-dependent oxidoreductase: an overview	10
Cold stress regulates accumulation of flavonoids and terpenoids in plants by phytohormone, transcription process, functional enzyme, and epigenetics	10
Cambial meristematic cell culture: a sustainable technology toward in vitro specialized metabolites production	10
Pulmonary delivery systems for antimicrobial peptides	9
Advances in pharmacology, biosynthesis, and metabolic engineering of Scutellaria -specialized metabolites	9
Biotechnological application of Aureobasidium spp. as a promising chassis for biosynthesis of ornithine-urea cycle-derived bioproducts	9
Challenges and opportunities for the production of lactic acid bacteria inoculants aimed for ensiling processes	9
Biodegradable acids for pyrite depression and green flotation separation – an overview	9
Mitigating toxic formaldehyde to promote efficient utilization of C1 resources	9
Microalgae harvesting techniques: updates and recent technological interventions	9
Application of protein engineering to ene-reductase for the synthesis of chiral compounds through asymmetric reaction	9
Air biofilters for a mixture of organic gaseous pollutants: an approach for industrial applications	8
Fast-growing cyanobacterial chassis for synthetic biology application	8
Xylooligosaccharides mediated gut microbiome modulation: prebiotics to postbiotics	8
Advancements in multi-omics for nutraceutical enhancement and traits improvement in buckwheat	8
Biocontrol of plant pathogens in omics era—with special focus on endophytic bacilli	8
Chassis engineering for high light tolerance in microalgae and cyanobacteria	8
Exploring future applications of the apiculate yeast Hanseniaspora	8
Biosynthesis, acquisition, regulation, and upcycling of heme: recent advances	8