Journal of Leukocyte Biology

Article	Citations
Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and therapy concepts	546
Frontline Science: COVID-19 infection induces readily detectable morphologic and inflammation-related phenotypic changes in peripheral blood monocytes	171
NLRP3 inflammasome priming: A riddle wrapped in a mystery inside an enigma	125
Natural products and their derivatives: Promising modulators of tumor immunotherapy	118
Innate immune receptors in platelets and platelet-leukocyte interactions	98
Neutrophil calprotectin identifies severe pulmonary disease in COVID-19	92
Multiple roles of caspase-8 in cell death, inflammation, and innate immunity	83
Cytokine release syndrome in COVID-19: Innate immune, vascular, and platelet pathogenic factors differ in severity of disease and sex	82
The vitals of NETs	79
Genome-wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID-19	78
Neutrophils mediate Th17 promotion in COVID-19 patients	64
Increasing complexity of NLRP3 inflammasome regulation	62
IFNγ-mediated repression of system xc− drives vulnerability to induced ferroptosis in hepatocellular carcinoma cells	59
Leptin correlates with monocytes activation and severe condition in COVID-19 patients	58
The microbiota-gut-bone axis and bone health	57
Specialized immune responses in the peritoneal cavity and omentum	56
Neutrophil recruitment by chemokines Cxcl1/KC and Cxcl2/MIP2: Role of Cxcr2 activation and glycosaminoglycan interactions	56
The role of the microbiome and the NLRP3 inflammasome in the gut and lung	53
Surmounting the obstacles that impede effective CAR T cell trafficking to solid tumors	50
Cellular immune responses in the pathophysiology of preeclampsia	48
Alveolar and lung interstitial macrophages: Definitions, functions, and roles in lung fibrosis	46
Trophoblast-secreted soluble-PD-L1 modulates macrophage polarization and function	44
B cell analysis in SARS-CoV-2 versus malaria: Increased frequencies of plasmablasts and atypical memory B cells in COVID-19	43
Roles of IL-2 in bridging adaptive and innate immunity, and as a tool for cellular immunotherapy	41
Notch signaling at the crossroads of innate and adaptive immunity	40

Identification of key signaling pathways induced by SARS-CoV2 that underlie thrombosis and vascular injury in COVID-19 patients	38
The neuro-immune microenvironment of acupoints—initiation of acupuncture effectiveness	37
Sustained calcium ion release from bioceramics promotes CaSR-mediated M2 macrophage polarization for osteoinduction	37
Intestinal intraepithelial lymphocytes: Maintainers of intestinal immune tolerance and regulators of intestinal immunity	37
Molecular interactions and functions of IL-32	36
HLA-DR-expressing NK cells: Effective killers suspected for antigen presentation	35
Age-related changes in intestinal immunity and the microbiome	35
Porphyromonas gingivalisinduces periodontitis, causes immune imbalance, and promotes rheumatoid arthritis	34
From virus to inflammation, how influenza promotes lung damage	33
Direct and indirect regulation of the tumor immune microenvironment by VEGF	33
Neutrophils produce proinflammatory or anti-inflammatory extracellular vesicles depending on the environmental conditions	32
ADAM17/MMP inhibition prevents neutrophilia and lung injury in a mouse model of COVID-19	31
Severe COVID-19 is marked by dysregulated serum levels of carboxypeptidase A3 and serotonin	31
Intersection between macrophages and periodontal pathogens in periodontitis	31
Ginsenoside Rg1 ameliorates sepsis-induced acute kidney injury by inhibiting ferroptosis in renal tubular epithelial cells	31
Unraveling exhaustion in adaptive and conventional NK cells	30
RAC2 and primary human immune deficiencies	29
Regulatory functions of NK cells during infections and cancer	28
At the Bench: Pre-clinical evidence for multiple functions of CXCR4 in cancer	28
Dynamic changes in human single-cell transcriptional signatures during fatal sepsis	28
Influenza A virus directly modulates mouse eosinophil responses	28
Role of IL-6 in dendritic cell functions	27
PB1-F2 protein of highly pathogenic influenza A (H7N9) virus selectively suppresses RNA-induced NLRP3 inflammasome activation through inhibition of MAVS-NLRP3 interaction	27
Drug target validation in primary human natural killer cells using CRISPR RNP	27
Identification of a regulatory Vδ1 gamma delta T cell subpopulation expressing CD73 in human breast cancer	26
Changing the paradigm of IFN-γ at the interface between innate and adaptive immunity: Macrophage-derived IFN-γ	26
Tumor inhibition or tumor promotion? The duplicity of CXCR3 in cancer	25
LPS-mediated neutrophil VEGF-A release is modulated by cannabinoid receptor activation	25
Emergence of immunosuppressive LOX-1+ PMN-MDSC in septic shock and severe COVID-19 patients with acute respiratory distress syndrome	24
Spinal microglia-neuron interactions in chronic pain	24
Platelet extracellular vesicles in COVID-19: Potential markers and makers	24
IL-34 and CSF-1, deciphering similarities and differences at steady state and in diseases	24
T follicular helper cells in the humoral immune response to SARS-CoV-2 infection and vaccination	24
Loss of mitochondrial membrane potential (ΔΨm) in leucocytes as post-COVID-19 sequelae	24
Use of integrated metabolomics, transcriptomics, and signal protein profile to characterize the effector function and associated metabotype of polarized macrophage phenotypes	24
Mechanisms of NK cell dysfunction in the tumor microenvironment and current clinical approaches to harness NK cell potential for immunotherapy	24
Follicular helper T cells and follicular regulatory T cells in the immunopathology of primary Sjögren’s syndrome	24
CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4	24
Differential expression and regulation of MS4A family members in myeloid cells in physiological and pathological conditions	23
MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression	23
TNFR2 blockade alone or in combination with PD-1 blockade shows therapeutic efficacy in murine cancer models	22
The spleen: “epicenter” in malaria infection and immunity	22
Andrographolide exerts anti-inflammatory effects in Mycobacterium tuberculosis-infected macrophages by regulating the Notch1/Akt/NF-κB axis	22
Periodontal ligament stem cells in the periodontitis niche: inseparable interactions and mechanisms	22
Breakthrough concepts in immune-oncology: Cancer vaccines at the bedside	22
BTK/ITK dual inhibitors: Modulating immunopathology and lymphopenia for COVID-19 therapy	22
Malassezia spp. induce inflammatory cytokines and activate NLRP3 inflammasomes in phagocytes	22
T regulatory cells-derived extracellular vesicles and their contribution to the generation of immune tolerance	22
T cell counts and IL-6 concentration in blood of North African COVID-19 patients are two independent prognostic factors for severe disease and death	22
CAR NK-92 cells targeting DLL3 kill effectively small cell lung cancer cells in vitro and in vivo	22

Periodontal ligament stem cells promote polarization of M2 macrophages	21
Analysis of deficiency of adenosine deaminase 2 pathogenesis based on single-cell RNA sequencing of monocytes	21
CD56dimCD57−NKG2C+ NK cells retaining proliferative potential are possible precursors of CD57+NKG2C+ memory-like NK cells	21
Melanoma-derived extracellular vesicles skew neutrophils into a pro-tumor phenotype	21
Macrophage M1/M2 polarization dynamically adapts to changes in microenvironment and modulates alveolar bone remodeling after dental implantation	21
HMGB1: An overview of its roles in the pathogenesis of liver disease	21
Classically activated mouse macrophages produce methylglyoxal that induces a TLR4- and RAGE-independent proinflammatory response	20
Regulatory CD4+ and CD8+ T cells are negatively correlated with CD4+/CD8+ T cell ratios in patients acutely infected with SARS-CoV-2	20
NLRC4 biology in immunity and inflammation	20
Frontline Science: AMPK regulates metabolic reprogramming necessary for interferon production in human plasmacytoid dendritic cells	20
FOXO3a acetylation regulates PINK1, mitophagy, inflammasome activation in murine palmitate-conditioned and diabetic macrophages	20
Pro-inflammatory polarization primes Macrophages to transition into a distinct M2-like phenotype in response to IL-4	20
Flow cytometric evaluation of the neutrophil compartment in COVID-19 at hospital presentation: A normal response to an abnormal situation	19
IL-38 prevents induction of trained immunity by inhibition of mTOR signaling	19
Role of extracellular vesicles in atherosclerosis: An update	19
MiR-155 regulates neutrophil extracellular trap formation and lung injury in abdominal sepsis	19
Frontline Science: Characterization and regulation of osteoclast precursors following chronic Porphyromonas gingivalis infection	19
Targeting NLRP3 and Staphylococcal pore-forming toxin receptors in human-induced pluripotent stem cell-derived macrophages	19
IL-17a exacerbates hepatic ischemia–reperfusion injury in fatty liver by promoting neutrophil infiltration and mitochondria-driven apoptosis	18
The imbalance of Th17/Treg via STAT3 activation modulates cognitive impairment inP. gingivalis LPS-induced periodontitis mice	18
LncRNA SNHG12 alleviates hypertensive vascular endothelial injury through miR-25-3p/SIRT6 pathway	18
Scientific premise for the involvement of neutrophil extracellular traps (NETs) in vaccine-induced thrombotic thrombocytopenia (VITT)	18
Interplay between alveolar epithelial and dendritic cells and Mycobacterium tuberculosis	18
Mismatch between circulating cytokines and spontaneous cytokine production by leukocytes in hyperinflammatory COVID-19	18
Functional crosstalk between T cells and monocytes in cancer and atherosclerosis	17
Anticancer effects of disulfiram in T-cell malignancies through NPL4-mediated ubiquitin–proteasome pathway	17
Dengue virus-activated platelets modulate monocyte immunometabolic response through lipid droplet biogenesis and cytokine signaling	17
Inhibitory effect of sinomenine on lung cancer cells via negative regulation of α7 nicotinic acetylcholine receptor	17
Plasma extracellular vesicles released after severe burn injury modulate macrophage phenotype and function	16
Role of vitamin D in regulating COVID-19 severity—An immunological perspective	16
Immunomodulatory functions of oral mesenchymal stem cells: Novel force for tissue regeneration and disease therapy	16
The lymphatic drainage system of the CNS plays a role in lymphatic drainage, immunity, and neuroinflammation in stroke	16
Brief review on the roles of neutrophils in cancer development	16
The multiple ways Wnt signaling contributes to acute leukemia pathogenesis	16
Extracellular vesicles in inflammation: Focus on the microRNA cargo of EVs in modulation of liver diseases	16
Aloe emodin relieves Ang II-induced endothelial junction dysfunction via promoting ubiquitination mediated NLRP3 inflammasome inactivation	16
Functional selective FPR1 signaling in favor of an activation of the neutrophil superoxide generating NOX2 complex	16
The neutrophil subset defined by CD177 expression is preferentially recruited to gingival crevicular fluid in periodontitis	16
Stem cell-like memory T cells: The generation and application	15
Impact of age-, cancer-, and treatment-driven inflammation on T cell function and immunotherapy	15
Macrophage dysfunction in cystic fibrosis: Nature or nurture?	15
VIP plasma levels associate with survival in severe COVID-19 patients, correlating with protective effects in SARS-CoV-2-infected cells	15
Frontline Science: Extracellular CIRP generates a proinflammatory Ly6G+CD11bhi subset of low-density neutrophils in sepsis	15
Immune modulatory effects of progesterone on oxLDL-induced trained immunity in monocytes	15
The regulatory role of insulin in energy metabolism and leukocyte functions	15
Mendelian diseases of dysregulated canonical NF-κB signaling: From immunodeficiency to inflammation	15
Tensile force transmitted through LFA-1 bonds mechanoregulate neutrophil inflammatory response	15
Sepsis, pyruvate, and mitochondria energy supply chain shortage	15
Frontline Science: Kindlin-3 is essential for patrolling and phagocytosis functions of nonclassical monocytes during metastatic cancer surveillance	15
Escape of tumor cells from the NK cell cytotoxic activity	15
Frontline Science: Anthrax lethal toxin-induced, NLRP1-mediated IL-1β release is a neutrophil and PAD4-dependent event	15
TCF-1 maintains CD8+ T cell stemness in tumor microenvironment	15
Stress aggravates and prolongs imiquimod-induced psoriasis-like epidermal hyperplasis and IL-1β/IL-23p40 production	15
Synthesis and identification of lithocholic acid 3-sulfate as RORγt ligand to inhibit Th17 cell differentiation	15
Histone H4 directly stimulates neutrophil activation through membrane permeabilization	15
Systematic reassessment of chemokine-receptor pairings confirms CCL20 but not CXCL13 and extends the spectrum of ACKR4 agonists to CCL22	15
LncRNA SNHG8 sponges miR-449c-5p and regulates the SIRT1/FoxO1 pathway to affect microglia activation and blood-brain barrier permeability in ischemic stroke	15
Characterization of memory T cell subsets and common γ−chain cytokines in convalescent COVID-19 individuals	14
Neutrophil dysfunction triggers inflammatory bowel disease in G6PC3 deficiency	14
Sinomenine increases adenosine A2A receptor and inhibits NF-κB to inhibit arthritis in adjuvant-induced-arthritis rats and fibroblast-like synoviocytes through α7nAChR	14
Novel TREM2 splicing isoform that lacks the V-set immunoglobulin domain is abundant in the human brain	14
Macrophage migration inhibitory factor inhibits neutrophil apoptosis by inducing cytokine release from mononuclear cells	14
Serum-borne lipids amplify TLR-activated inflammatory responses	13
Frontline Science: LPS-inducible SLC30A1 drives human macrophage-mediated zinc toxicity against intracellular Escherichia coli	13
P2Y12 antagonism results in altered interactions between platelets and regulatory T cells during sepsis	13
Diabetes induces macrophage dysfunction through cytoplasmic dsDNA/AIM2 associated pyroptosis	13
Frontline Science: P2Y11 receptors support T cell activation by directing mitochondrial trafficking to the immune synapse	13
The functions of EZH2 in immune cells: Principles for novel immunotherapies	13
Monocytic myeloid-derived suppressor cells reflect tuberculosis severity and are influenced by cyclooxygenase-2 inhibitors	13
At the Bedside: Profiling and treating patients with CXCR4-expressing cancers	13
The mechanism of Chinese herbal formula HQT in the treatment of rheumatoid arthritis is related to its regulation of lncRNA uc.477 and miR-19b	13
GABAergic signaling in human and murine NK cells upon challenge withToxoplasma gondii	13
Extracellular vesicle-mediated crosstalk between melanoma and the immune system: Impact on tumor progression and therapy response	13
Alpha lipoic acid promotes development of hematopoietic progenitors derived from human embryonic stem cells by antagonizing ROS signals	13
TLR3 expression by maternal and fetal cells at the maternal-fetal interface in normal and preeclamptic pregnancies	13
Gut microbiota shape B cell in health and disease settings	12
Research advances in nanomedicine, immunotherapy, and combination therapy for leukemia	12
Monocyte subsets predict mortality after cardiac arrest	12
Quantitative single-molecule imaging of TNFR1 reveals zafirlukast as antagonist of TNFR1 clustering and TNFα-induced NF-ĸB signaling	12
Innate lymphoid cell and adaptive immune cell cross-talk: A talk meant not to forget	12

Circulating inflammatory cell profiling and periodontitis: A systematic review and meta-analysis	12
In silico design of a TLR4-mediating multiepitope chimeric vaccine against amyotrophic lateral sclerosis via advanced immunoinformatics	12
Insulin acutely activates metabolism of primary human monocytes and promotes a proinflammatory phenotype	12
Frontline Science: Activation of metabolic nuclear receptors restores periodontal tissue homeostasis in mice with leukocyte adhesion deficiency-1	12
Emerging neutrophil plasticity: Terminally differentiated cells no more	12
The adaptive immune response to Clostridioides difficile: A tricky balance between immunoprotection and immunopathogenesis	12
Neuroimmune regulatory networks of the airway mucosa in allergic inflammatory disease	12
The role of bacterial DNA containing CpG motifs in diseases	12
A novel strategy to dissect multifaceted macrophage function in human diseases	12
Profiling cellular heterogeneity in asthma with single cell multiparameter CyTOF	12
Guanylate binding proteins contained in the murine chromosome 3 are important to control mycobacterial infection	12