Journal of Pineal Research

Article	Citations
Melatonin Increased Autophagy Level to Facilitate Osteogenesis of Inflamed PDLSCs Through TMEM110 Signaling Pathways	152
A phase II, single‐center, double‐blind, randomized placebo‐controlled trial to explore the efficacy and safety of intravenous melatonin in surgical patients with severe sepsis admitted to the intensi	90
Correction to high sensitivity of melatonin suppression response to evening light in preschool‐aged children	80
RETRACTION: Changes in the Expression of Melatonin Receptors Induced by Melatonin Treatment in Hepatocarcinoma HepG2 Cells	74
Zygotic Exposure to Venlafaxine Disrupts the Circadian Locomotor Activity Behaviour in Zebrafish Larvae	71
Transcriptomic and Metabolomic Signatures of Acute Circadian Misalignment in Mice	70
BPS‐induced ovarian dysfunction: Protective actions of melatonin via modulation of SIRT‐1/Nrf2/NFĸB and IR/PI3K/pAkt/GLUT‐4 expressions in adult golden hamster	61
Melatonin targets MoIcl1 and works synergistically with fungicide isoprothiolane in rice blast control	56
Melatonin mediates reactive oxygen species homeostasis via SlCV to regulate leaf senescence in tomato plants	54
Melatonin as a chronobiotic/cytoprotective agent in bone. Doses involved	50
Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications	47
Corrigendum to Melatonin Attenuates D‐Galactose‐Induced Memory Impairment, Neuroinflammation and Neurodegeneration via Rage/Nf‐ K B/Jnk Signaling Pat	45
Microbial Melatonin Production Improves Plant Metabolic Function in Short‐Term Climate‐Induced Stresses	43
From Seasonality to Species Conservation: Chronobiological Research on European Hamsters in Strasbourg, France	42
Melatonin inhibits chondrosarcoma cell proliferation and metastasis by enhancing miR‐520f‐3p production and suppressing MMP7 expression	42
Investigating the safety profiles of exogenous melatonin and associated adverse events: A pharmacovigilance study using WHO‐VigiBase	42
Issue Information	40
Optimizing the Time and Dose of Melatonin as a Sleep‐Promoting Drug: A Systematic Review of Randomized Controlled Trials and Dose−Response Meta‐Analysis	40
Melatonin Ameliorates Atherosclerotic Plaque Vulnerability by Regulating PPARδ‐Associated Smooth Muscle Cell Phenotypic Switching	39
Erratum to: Mitochondrial cytochrome P450 (CYP) 1B1 is responsible for melatonin‐induced apoptosis in neural cancer cells	37
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Light‐Dependent Circadian Rhythm Governs O‐GlcNAc Cycling to Influence Cognitive Function in Adult Zebrafish	36
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Anti‐PANoptosis is involved in neuroprotective effects of melatonin in acute ocular hypertension model	35
Melatonin Enhances Peanut Productivity by Enriching Root‐Associated Nitrogen‐Fixing Bacteria	34

Exogenous Melatonin Regulates Hormone Signalling and Photosynthesis‐Related Genes to Enhance Brassica napus. Yield: A Transcriptomic Perspective	34
Relationship Between Urinary 6‐Sulfatoxymelatonin Rhythms and the Bone Resorption Marker Amino‐Terminal Cross‐Linked Telopeptide of Collagen I in Blind Women	33
3‐Month Melatonin Supplementation to Reduce Brain Oxidative Stress and Improve Sleep in Mild Cognitive Impairment: A Randomised Controlled Feasibility Trial	32
From gestational chronodisruption to noncommunicable diseases: Pathophysiological mechanisms of programming of adult diseases, and the potential therapeutic role of melatonin	31
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RETRACTION: Melatonin Suppresses Proinflammatory Mediators in Lipopolysaccharide‐Stimulated CRL1999 Cells via Targeting MAPK, NF‐κB, c/EBPβ, and p300 Signaling	30
Effect of melatonin cream on acute radiation dermatitis in patients with primary breast cancer: A double‐blind, randomized, placebo‐controlled trial	30
RETRACTION: Melatonin Inhibits the Expression of the Inducible Isoform of Nitric Oxide Synthase and Nuclear Factor Kappa B Activation in Rat Skeletal Muscle	30
Correction to “Melatonin mediates selenium‐induced tolerance to cadmium stress in tomato plants”	27
Light Environment of Arctic Solstices is Coupled With Melatonin Phase‐Amplitude Changes and Decline of Metabolic Health	25
Melatonin improves skin barrier damage caused by sleep restriction through gut microbiota	25
Melatonin prevents EAAC1 deletion‐induced retinal ganglion cell degeneration by inhibiting apoptosis and senescence	25
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EXPRESSION OF CONCERN: Mitochondrial Function Is Controlled by Melatonin and Its Metabolites In Vitro in Human Melanoma Cells	22
Melatonin Defends Against the Oxidative Stress by Preventing the Uptake of Nanoplastics and Activating the Antioxidant System in Paeonia ostii	22
Homeobox gene‐encoded transcription factors in development and mature circadian function of the rodent pineal gland	22
Effect of melatonin on ATG2B‐mediated autophagy regulation in sheep granulosa cells with different FecB genotypes	22
Melatonin Rescues Influenza A Virus–Induced Cellular Energy Exhaustion via OMA1‐OPA1‐S in Acute Exacerbation of COPD	21
Multi‐Omics Analysis Reveals That AhNHL Contributes to Melatonin‐Mediated Cadmium Tolerance in Peanut Plants	21
Melatonin Ameliorates Circadian Disruption‐Associated Dry Eye via Modulation of BMAL1‐REV‐ERBα‐IL‐17 Axis and Ocular Surface Microbiota Homeostasis	21
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Orphan GPR50 Restrains Neurite Outgrowth and Cell Migration by Activating the G12/13 Protein‐RhoA Pathway in Neural Progenitor Cells and Tanycytes	20
In Vitro and In Vivo Effects of Melatonin‐Containing Combinations in Human Pancreatic Ductal Adenocarcinoma	20
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Melatonin Alleviates Osteoarthritis by Regulating NADPH Oxidase 4–Induced Ferroptosis and Mitigating Mitochondrial Dysfunction	19
Protective Effects of Melatonin on Kidney Function Against Contrast Media‐Induced Kidney Damage in Patients With Chronic Kidney Disease: A Prospective, Randomized, Double‐Blinded, Placebo‐Controlled T	19
Relating Photoperiod and Outdoor Temperature With Sleep Architecture in Patients With Neuropsychiatric Sleep Disorders	19
Mouse Models in Circadian Rhythm and Melatonin Research	19
Melatonin‐Mediated Alleviation of Plant Response to Heavy Metals: From Integrative Mechanisms to Potential Applications	18
Melatonin Membrane Receptors in the Vascular System: Function, Modulation and Clinical Relevance	18
Melatonin Affects Peucedanum praeruptorum Vegetative Growth and Coumarin Synthesis by Modulating the Antioxidant System, Photosynthesis, and Endogenous H	18
NPAS2 Deficiency Leads to Antidepressant‐Like Behaviors in Mice by Modulating Astrocyte‐Mediated Neuroinflammation	18
Melatonin as a key regulator in seed germination under abiotic stress	17
Correction to “Melatonin/PGC1A/UCP1 promotes tumor slimming and represses tumor progression by initiating autophagy and lipid browning”	17
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Melatonin sensitizes leukemia cells to the MCL1 inhibitors S63845 and A‐1210477 through multiple pathways	17
Cyclic uniaxial mechanical load enhances chondrogenesis through entraining the molecular circadian clock	17
Melatonin and Exercise Restore Myogenesis and Mitochondrial Dynamics Deficits Associated With Sarcopenia in iMS‐ Bmal1 −/−	17
IAT4 , a New Indolamine N ‐Acetyltransferase in Saccharomyces cerevisiae Involv	16
Thirty‐seven years of MT1 and MT2 melatonin receptor localization in the brain: Past and future challenges	16
Melatonin Inhibits Endometriosis Growth via Specific Binding and Inhibition of EGFR Phosphorylation	16
Time‐of‐Day Impacts Uterine Circadian Rhythms and Response to Oxytocin: Comparison of Uterine Function in Melatonin‐Deficient C57BL/6 Versus Melatonin Proficient CBA/B6 Hybrid Mice	16
The Mechanism by Which Melatonin Improves the Dysregulation of Glucose and Lipid Metabolism in Castrated Female Mice	16
Melatonin inhibits endometriosis development by disrupting mitochondrial function and regulating tiRNAs	15
Greater sensitivity of the circadian system of women to bright light, but not dim‐to‐moderate light	15
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Melatonin, an Antitumor Necrosis Factor Therapy	15
Hypnotic effects of melatonin depend on the environmental lighting conditions in the rat	15
Melatonin Regulates Rheumatoid Synovial Fibroblasts‐Related Inflammation: Implications for Pathological Skeletal Muscle Treatment	15

Melatonin protects against developmental PBDE‐47 neurotoxicity by targeting the AMPK/mitophagy axis	15
Melatonin MT1 receptors regulate the Sirt1/Nrf2/Ho‐1/Gpx4 pathway to prevent α‐synuclein‐induced ferroptosis in Parkinson's disease	15
RETRACTION: Melatonin Inhibits Autophagy and Endoplasmic Reticulum Stress in Mice With Carbon Tetrachloride‐Induced Fibrosis	15
Zebrafish Dark‐Dependent Behavior Requires Phototransduction by the Pineal Gland	14
Melatonin Supplementation Alleviates Bone Mineral Density Decline and Circulating Oxidative Stress in Iron‐Overloaded Thalassemia Patients	14
Quality‐of‐life outcomes following topical melatonin application against acute radiation dermatitis in patients with early breast cancer: A double‐blind, randomized, placebo‐controlled trial	14
Melatonin Enhances the Myometrial Contraction Through MT2‐PKC‐NRF2/MAFF Signaling Pathway in Sows	14
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Melatonin Regulates Neuronal Synaptic Plasticity in the Supramammillary Nucleus and Attenuates Methamphetamine‐Induced Conditioned Place Preference and Sensitization in Mice	14
Standardized and Calibrated Light Stimuli via Head‐Mounted Displays for Investigating the Nonvisual Effects of Light	13
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Histone deacetylase 9 regulates disease resistance through fine‐tuning histone deacetylation of melatonin biosynthetic genes and melatonin accumulation in cassava	13
Criticism on the Incorrect Use of Oxygen–Ozone Therapy in Medicine	13
Direct Peritoneal Resuscitation and Melatonin in the Treatment of Abdominal Sepsis‐Induced Lung Injury via Macrophage Metabolic Reprogramming	13
KARS Mutations Impair Brain Myelination by Inducing Oligodendrocyte Deficiency: One Potential Mechanism and Improvement by Melatonin	13
Melatonin functions as a broad‐spectrum antifungal by targeting a conserved pathogen protein kinase	13
Melatonin and Seasonal Synchrony in Mammals	12
Melatonin reduces brain injury following inflammation‐amplified hypoxia–ischemia in a translational newborn piglet study of neonatal encephalopathy	12
Dose assessment of melatonin in sepsis (DAMSEL2) study: Pharmacokinetics of two doses of oral melatonin in patients with sepsis	12
Cross‐species single‐cell landscape of vertebrate pineal gland	12
Melatonin, Melatonin Receptors and Sleep: Moving Beyond Traditional Views	12
Melatonin receptor structure and signaling	12
Melatonin rescues the mitochondrial function of bone marrow‐derived mesenchymal stem cells and improves the repair of osteoporotic bone defect in ovariectomized rats	12
Issue Information	12
Melatonin alleviates myocardial dysfunction through inhibition of endothelial‐to‐mesenchymal transition via the NF‐κB pathway	11
Melatonin‐mediated malic enzyme 2 orchestrates mitochondrial fusion and respiratory functions to promote odontoblastic differentiation during tooth development	11
Coupling Melatonin and Ultrasound Modulates ROS Production, Antioxidant System, and Biochemical Attributes Linked to Oxidative Browning in Litchi Pericarp	11
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OPA1 Mediated Fatty Acid β‐Oxidation in Hepatocyte: The Novel Insight for Melatonin Attenuated Apoptosis in Concanavalin A Induced Acute Liver Injury	11
Key Role of the CRE Sequence in the Per1 Promoter in Mediating the Switch Between Unipolar and Bipolar Depression‐Like Behaviors	11
Issue Information	11
Correction to “Effects of melatonin on fatty liver disease: The role of NR4A1/DNA‐PKcs/p53 pathway, mitochondrial fission, and mitophagy”	11
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Melatonin Is Bound to a Glycolytic Protein Complex via Tdh2p During Fermentation in Saccharomyces cerevisiae	10
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Melatonin Overcomes Cancer Multidrug Resistance by Downregulating ABCB1 Expression and Modulating Mitochondrial Function	10
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RETRACTION: Melatonin Induces Cell Cycle Arrest and Apoptosis in Hepatocarcinoma HepG2 Cell Line	10
RETRACTION: Melatonin Modulates Dysregulated Circadian Clocks in Mice With Diethylnitrosamine‐Induced Hepatocellular Carcinoma	10
Melatonin Alleviates Oxidative Stress‐Induced Mitochondrial Dysfunction Through Ameliorating NAD + Homeostasis of hDPSCs for Cell‐Based Therapy	10
Melatonin facts: Lack of evidence that melatonin is a radical scavenger in living systems	10
Evening chronotype is associated with hormonal and metabolic disorders in polycystic ovary syndrome	10
EXPRESSION OF CONCERN: Melatonin Protects Against Isoproterenol‐Induced Alterations in Cardiac Mitochondrial Energy‐Metabolizing Enzymes, Apoptotic Proteins, and Assists in Complete Recovery From Myoc	9
Melatonin may suppress lung adenocarcinoma progression via regulation of the circular noncoding RNA hsa_circ_0017109/miR‐135b‐3p/TOX3 axis	9
Protective Activity of Melatonin Combinations and Melatonin‐Based Hybrid Molecules in Neurodegenerative Diseases	9
Identification of a COMT Gene Involved in the Biosynthesis of Melatonin Which Mediates Resistance to Citrus Canker	9
Biosynthesis of neuroprotective melatonin is dysregulated in Huntington's disease	9
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Correction to “PP2C1 Fine‐Tunes Melatonin Biosynthesis and Phytomelatonin Receptor PMTR1 Binding to Melatonin in Cassava”	8
Melatonin improves cardiac remodeling and brain–heart sympathetic hyperactivation aggravated by light disruption after myocardial infarction	8
Melatonin ameliorates myocardial infarction in obese diabetic individuals: The possible involvement of macrophage apoptotic factors	8
Identification of Predictors of Shift Work Adaptation and Its Association With Immune, Hormonal and Metabolite Biomarkers	8
Proteomic Signatures Underlying Sleep, Circadian Activity Patterns, and Major Chronic Diseases	8
Mechanism of Exogenous Melatonin to Alleviate the Fermentation Performance of Saccharomyces cerevisiae Under Copper Stress	8
Corrigendum to “melatonin ameliorates PM2.5‐induced cardiac perivascular fibrosis through regulating mitochondrial redox homeostasis”	8
RETRACTION: Melatonin Inhibits the Sphingosine Kinase 1/Sphingosine‐1‐Phosphate Signaling Pathway in Rabbits With Fulminant Hepatitis of Viral Origin	8
Issue Information	8
Novel melatonin‐producing Bacillus safensis EH143 mitigates salt and cadmium stress in soybean	7
RP58 knockdown contributes to hypoxia‐ischemia‐induced pineal dysfunction and circadian rhythm disruption in neonatal rats	7
Delayed circadian rhythms in older Africans living with human immunodeficiency virus (HIV)	7
Chronic developmental hypoxia alters mitochondrial oxidative capacity and reactive oxygen species production in the fetal rat heart in a sex‐dependent manner	7
Design, Synthesis, and Antifungal Activity of Melatonin Derivatives Containing a (Thio)Semicarbazide Group	7
Issue Information	7
Primary Gamma Knife Radiosurgery for pineal region tumors: A systematic review and pooled analysis of available literature with histological stratification	7
Ramelteon for delirium prevention in hospitalized patients: An updated meta‐analysis and trial sequential analysis of randomized controlled trials	7
Melatonin Influences Bmi1 + Intestinal Stem Cell Fate Through Metabolic Regulation After Irradiation	6
Melatonin: A Potential Therapy for Osteoporosis With Insights Into Molecular Mechanisms	6
Functional Characterization of GNA1 as a Serotonin N ‐Acetyltransferase Reveals a Key Role in the Serotonin to Melatonin Pathway in <	6
In vitro deacetylation of N‐acetylserotonin by arylacetamide deacetylase	6
Meditation Linked to Enhanced MRI Signal Intensity in the Pineal Gland and Reduced Predicted Brain Age	6
Issue Information	6
Combinatory Effects of Indoximod and Melatonin Alleviate Myeloid Derived Suppressor Cells Driven Triple Negative Breast Cancer Progression and Metastasis	6
Melatonin Protects Against Colistin‐Induced Intestinal Inflammation and Microbiota Dysbiosis	6
Light and Temperature Coordinately Regulate Phytomelatonin Synthesis to Maintain Plant Morphogenesis via the COP1‐HY5 Module	6
Issue Information	6
EXPRESSION OF CONCERN: Melatonin Protects Against Endometriosis via Regulation of Matrix Metalloproteinase‐3 and an Apoptotic Pathway	6
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Rational modification of melatonin for broad‐spectrum antifungal agents discovery	5
Recharge of chondrocyte mitochondria by sustained release of melatonin protects cartilage matrix homeostasis in osteoarthritis	5
The ISL LIM‐homeobox 2 transcription factor is negatively regulated by circadian adrenergic signaling to repress the expression of Aanat in pinealocytes of the rat pineal gland	5
EXPRESSION OF CONCERN: Melatonin Potentiates the Antiproliferative and Pro‐Apoptotic Effects of Ursolic Acid in Colon Cancer Cells by Modulating Multiple Signaling Pathways	5
Resetting of the Human Circadian Melatonin Rhythm by Ambient Hypoxia	5
Melatonin alleviates PM2.5‐induced glucose metabolism disorder and lipidome alteration by regulating endoplasmic reticulum stress	5
Melatonin Improves Diabetic‐Accelerated Experimental Osteoarthritis by Inhibiting NLRP3‐Mediated Chondrocyte Pyroptosis via PKG/Nrf2	5
Melatonin drives apoptosis in head and neck cancer by increasing mitochondrial ROS generated via reverse electron transport	5
RETRACTION: Melatonin Prevents Deregulation of the Sphingosine Kinase/Sphingosine 1‐Phosphate Signaling Pathway in a Mouse Model of Diethylnitrosamine‐Induced Hepatocellular Carcinoma	5
Relationship Between Melatonin Receptor Agonists and Parkinson's Disease	5
Melatonin Enhances Aquaporin 4 and Alpha‐Syntrophin Interaction by Inhibiting Cyclin‐Dependent Kinase 5 Activity to Preserve Glymphatic Function in Neonatal Hypoxic‐Ischemic Encephalopathy	5
Melatonin Repairs the Lipidome of Human Hepatocytes Exposed to Cd and Free Fatty Acid‐Induced Lipotoxicity	4
Issue Information	4
Correction to “Melatonin Inhibits Cd4+ T Cell Apoptosis via the Bcl‐2/BAX Pathway and Improves Survival Rates in Mice With Sepsis”	4
Brain‐Targeted RVG‐Liposomal Melatonin Ameliorates Manganese Neurotoxicity by Enhancing Neurogenesis and Modulating Systemic Amino Acid Profiles	4
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Exogenous Melatonin Enhances Waterlogging Tolerance in Sesame by Modulating Physiological, Biochemical, and Proteomic Responses	4
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N1‐Acetyl‐5‐methoxykynuramine, which decreases in the hippocampus with aging, improves long‐term memory via CaMKII/CREB phosphorylation	4
Circadian Rhythm Timing and Associations With Sleep Symptoms in People With Insomnia	4
Melatonin Prevents Thioacetamide–Induced Gut Leakiness and Liver Fibrosis Through the Gut–Liver Axis via Modulating Sirt1‐Related Deacetylation of Gut Junctional Complex and Hepatic Proteins	4
RETRACTION: Melatonin Attenuates Apoptotic Liver Damage in Fulminant Hepatic Failure Induced by the Rabbit Hemorrhagic Disease Virus	4
Safety and efficacy of melatonin supplementation as an add‐on treatment for infantile epileptic spasms syndrome: A randomized, placebo‐controlled, double‐blind trial	4
Adrenergic Agonists Activate Transcriptional Activity in Immortalized Neuronal Cells From the Mouse Suprachiasmatic Nucleus	4
Sleep Deprivation Exacerbates High‐Fat Diet‐Induced Obesity and MAFLD Through Melatonin Reduction Mediated NF‐κB Activation	3
Orchestrated feedback regulation between melatonin and sex hormones involving GPER1‐PKA‐CREB signaling in the placenta	3
Journal of Pineal Research guidelines for authors: Melatonin studies using plants	3
Issue Information	3
Healthy Lifestyles Modify the Association of Melatonin Receptor 1B Gene and Ischemic Stroke: A Family‐Based Cohort Study in Northern China	3
Manipulation of the Expression of SNAT1 Enhances Melatonin Biosynthesis, Promotes Plant Growth, and Improves Salt Stress Tolerance in Kiwifruit	3
Role and neural regulation of clock genes in the rat pineal gland: Clock modulates amplitude of rhythmic expression of Aanat encoding the melatonin‐producing enzyme	3
Melatonin Promotes the Synthesis and Secretion of Growth Hormone in the Adenohypophysis by Activating the cAMP/FOXO1 Pathway	3
Industrial and academic approaches to the search for alternative melatonin receptor ligands: An historical survey	3
Shift and longtime light induces endometrioid adenocarcinoma via activation of PKC‐α/Akt pathway in female golden hamster: Involvement of altered Aanat and Bmal1 rhythm	3
Melatonin suppression by light involves different retinal photoreceptors in young and older adults	3
Genetic and evolutionary dissection of melatonin response signaling facilitates the regulation of plant growth and stress responses	3
EXPRESSION OF CONCERN: Mechanisms of Isoproterenol‐Induced Cardiac Mitochondrial Damage: Protective Actions of Melatonin	3
RETRACTION: Regulation of Prostaglandin Production in Carrageenan‐Induced Pleurisy Melatonin	3
Discovery Begets Discovery: Special Edition on Melatonin and the Musculoskeletal System	3