Journal of Pineal Research

Article	Citations
A phase II, single‐center, double‐blind, randomized placebo‐controlled trial to explore the efficacy and safety of intravenous melatonin in surgical patients with severe sepsis admitted to the intensi	98
Correction to high sensitivity of melatonin suppression response to evening light in preschool‐aged children	84
RETRACTION: Changes in the Expression of Melatonin Receptors Induced by Melatonin Treatment in Hepatocarcinoma HepG2 Cells	77
Zygotic Exposure to Venlafaxine Disrupts the Circadian Locomotor Activity Behaviour in Zebrafish Larvae	75
Corrigendum to Melatonin Attenuates D‐Galactose‐Induced Memory Impairment, Neuroinflammation and Neurodegeneration via Rage/Nf‐ K B/Jnk Signaling Pat	73
Melatonin as a chronobiotic/cytoprotective agent in bone. Doses involved	62
Melatonin targets MoIcl1 and works synergistically with fungicide isoprothiolane in rice blast control	58
Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications	58
Microbial Melatonin Production Improves Plant Metabolic Function in Short‐Term Climate‐Induced Stresses	57
Melatonin Increased Autophagy Level to Facilitate Osteogenesis of Inflamed PDLSCs Through TMEM110 Signaling Pathways	52
Melatonin inhibits chondrosarcoma cell proliferation and metastasis by enhancing miR‐520f‐3p production and suppressing MMP7 expression	50
Transcriptomic and Metabolomic Signatures of Acute Circadian Misalignment in Mice	48
BPS‐induced ovarian dysfunction: Protective actions of melatonin via modulation of SIRT‐1/Nrf2/NFĸB and IR/PI3K/pAkt/GLUT‐4 expressions in adult golden hamster	45
From Seasonality to Species Conservation: Chronobiological Research on European Hamsters in Strasbourg, France	44
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Melatonin Ameliorates Atherosclerotic Plaque Vulnerability by Regulating PPARδ‐Associated Smooth Muscle Cell Phenotypic Switching	42
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Erratum to: Mitochondrial cytochrome P450 (CYP) 1B1 is responsible for melatonin‐induced apoptosis in neural cancer cells	41
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Melatonin Enhances Peanut Productivity by Enriching Root‐Associated Nitrogen‐Fixing Bacteria	38
EXPRESSION OF CONCERN: Melatonin Prevents Cadmium‐Induced Bone Damage: First Evidence on an Improved Osteogenic/Adipogenic Differentiation Balance of Mesenchymal Stem Cells as Underlying Mechanism	36
Light‐Dependent Circadian Rhythm Governs O‐GlcNAc Cycling to Influence Cognitive Function in Adult Zebrafish	36
Exogenous Melatonin Regulates Hormone Signalling and Photosynthesis‐Related Genes to Enhance Brassica napus. Yield: A Transcriptomic Perspective	36
Anti‐PANoptosis is involved in neuroprotective effects of melatonin in acute ocular hypertension model	35
Investigating the safety profiles of exogenous melatonin and associated adverse events: A pharmacovigilance study using WHO‐VigiBase	34

Optimizing the Time and Dose of Melatonin as a Sleep‐Promoting Drug: A Systematic Review of Randomized Controlled Trials and Dose−Response Meta‐Analysis	33
3‐Month Melatonin Supplementation to Reduce Brain Oxidative Stress and Improve Sleep in Mild Cognitive Impairment: A Randomised Controlled Feasibility Trial	32
From gestational chronodisruption to noncommunicable diseases: Pathophysiological mechanisms of programming of adult diseases, and the potential therapeutic role of melatonin	32
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RETRACTION: Melatonin Suppresses Proinflammatory Mediators in Lipopolysaccharide‐Stimulated CRL1999 Cells via Targeting MAPK, NF‐κB, c/EBPβ, and p300 Signaling	31
Correction to “Melatonin mediates selenium‐induced tolerance to cadmium stress in tomato plants”	28
RETRACTION: Melatonin Inhibits the Expression of the Inducible Isoform of Nitric Oxide Synthase and Nuclear Factor Kappa B Activation in Rat Skeletal Muscle	28
Melatonin prevents EAAC1 deletion‐induced retinal ganglion cell degeneration by inhibiting apoptosis and senescence	27
Melatonin improves skin barrier damage caused by sleep restriction through gut microbiota	25
RETRACTION: Inhibiting MT2‐TFE3‐Dependent Autophagy Enhances Melatonin‐Induced Apoptosis in Tongue Squamous Cell Carcinoma	24
Correction to “Identification, Transcriptional and Functional Analysis of Heat‐Shock Protein 90s in Banana ( Musa acuminata L.) Highlight Their Novel Rol	23
Light Environment of Arctic Solstices is Coupled With Melatonin Phase‐Amplitude Changes and Decline of Metabolic Health	23
Relationship Between Urinary 6‐Sulfatoxymelatonin Rhythms and the Bone Resorption Marker Amino‐Terminal Cross‐Linked Telopeptide of Collagen I in Blind Women	23
Effect of melatonin on ATG2B‐mediated autophagy regulation in sheep granulosa cells with different FecB genotypes	22
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EXPRESSION OF CONCERN: Mitochondrial Function Is Controlled by Melatonin and Its Metabolites In Vitro in Human Melanoma Cells	22
Issue Information	22
Homeobox gene‐encoded transcription factors in development and mature circadian function of the rodent pineal gland	22
Effect of melatonin cream on acute radiation dermatitis in patients with primary breast cancer: A double‐blind, randomized, placebo‐controlled trial	22
Multi‐Omics Analysis Reveals That AhNHL Contributes to Melatonin‐Mediated Cadmium Tolerance in Peanut Plants	21
Melatonin Ameliorates Circadian Disruption‐Associated Dry Eye via Modulation of BMAL1‐REV‐ERBα‐IL‐17 Axis and Ocular Surface Microbiota Homeostasis	21
Melatonin Defends Against the Oxidative Stress by Preventing the Uptake of Nanoplastics and Activating the Antioxidant System in Paeonia ostii	21
Orphan GPR50 Restrains Neurite Outgrowth and Cell Migration by Activating the G12/13 Protein‐RhoA Pathway in Neural Progenitor Cells and Tanycytes	21
Melatonin Rescues Influenza A Virus–Induced Cellular Energy Exhaustion via OMA1‐OPA1‐S in Acute Exacerbation of COPD	20
In Vitro and In Vivo Effects of Melatonin‐Containing Combinations in Human Pancreatic Ductal Adenocarcinoma	20
Correction to “Melatonin Attenuated Early Brain Injury Induced by Subarachnoid Hemorrhage via Regulating NLRP3 Inflammasome and Apoptosis Signaling”	20
Relating Photoperiod and Outdoor Temperature With Sleep Architecture in Patients With Neuropsychiatric Sleep Disorders	19
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Melatonin Alleviates Osteoarthritis by Regulating NADPH Oxidase 4–Induced Ferroptosis and Mitigating Mitochondrial Dysfunction	18
Melatonin as a key regulator in seed germination under abiotic stress	18
Mouse Models in Circadian Rhythm and Melatonin Research	18
Melatonin Membrane Receptors in the Vascular System: Function, Modulation and Clinical Relevance	18
Melatonin‐Mediated Alleviation of Plant Response to Heavy Metals: From Integrative Mechanisms to Potential Applications	18
Protective Effects of Melatonin on Kidney Function Against Contrast Media‐Induced Kidney Damage in Patients With Chronic Kidney Disease: A Prospective, Randomized, Double‐Blinded, Placebo‐Controlled T	18
Melatonin Affects Peucedanum praeruptorum Vegetative Growth and Coumarin Synthesis by Modulating the Antioxidant System, Photosynthesis, and Endogenous H	17
Correction to “Melatonin/PGC1A/UCP1 promotes tumor slimming and represses tumor progression by initiating autophagy and lipid browning”	17
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NPAS2 Deficiency Leads to Antidepressant‐Like Behaviors in Mice by Modulating Astrocyte‐Mediated Neuroinflammation	17
IAT4 , a New Indolamine N ‐Acetyltransferase in Saccharomyces cerevisiae Involv	17
Cyclic uniaxial mechanical load enhances chondrogenesis through entraining the molecular circadian clock	16
Melatonin, an Antitumor Necrosis Factor Therapy	16
The Mechanism by Which Melatonin Improves the Dysregulation of Glucose and Lipid Metabolism in Castrated Female Mice	16
Melatonin Inhibits Endometriosis Growth via Specific Binding and Inhibition of EGFR Phosphorylation	16
Melatonin protects against developmental PBDE‐47 neurotoxicity by targeting the AMPK/mitophagy axis	16
Melatonin sensitizes leukemia cells to the MCL1 inhibitors S63845 and A‐1210477 through multiple pathways	16
Melatonin and Exercise Restore Myogenesis and Mitochondrial Dynamics Deficits Associated With Sarcopenia in iMS‐ Bmal1 −/−	16
Thirty‐seven years of MT1 and MT2 melatonin receptor localization in the brain: Past and future challenges	16
Melatonin MT1 receptors regulate the Sirt1/Nrf2/Ho‐1/Gpx4 pathway to prevent α‐synuclein‐induced ferroptosis in Parkinson's disease	15
Hypnotic effects of melatonin depend on the environmental lighting conditions in the rat	15

Time‐of‐Day Impacts Uterine Circadian Rhythms and Response to Oxytocin: Comparison of Uterine Function in Melatonin‐Deficient C57BL/6 Versus Melatonin Proficient CBA/B6 Hybrid Mice	15
RETRACTION: Melatonin Inhibits Autophagy and Endoplasmic Reticulum Stress in Mice With Carbon Tetrachloride‐Induced Fibrosis	15
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Melatonin inhibits endometriosis development by disrupting mitochondrial function and regulating tiRNAs	15
Correction to “Melatonin Mediates Elevated Carbon Dioxide‐Induced Photosynthesis and Thermotolerance in Tomato”	15
Melatonin Regulates Rheumatoid Synovial Fibroblasts‐Related Inflammation: Implications for Pathological Skeletal Muscle Treatment	15
Zebrafish Dark‐Dependent Behavior Requires Phototransduction by the Pineal Gland	14
Melatonin Supplementation Alleviates Bone Mineral Density Decline and Circulating Oxidative Stress in Iron‐Overloaded Thalassemia Patients	14
Melatonin Regulates Neuronal Synaptic Plasticity in the Supramammillary Nucleus and Attenuates Methamphetamine‐Induced Conditioned Place Preference and Sensitization in Mice	14
Greater sensitivity of the circadian system of women to bright light, but not dim‐to‐moderate light	14
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KARS Mutations Impair Brain Myelination by Inducing Oligodendrocyte Deficiency: One Potential Mechanism and Improvement by Melatonin	13
Standardized and Calibrated Light Stimuli via Head‐Mounted Displays for Investigating the Nonvisual Effects of Light	13
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Criticism on the Incorrect Use of Oxygen–Ozone Therapy in Medicine	13
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Melatonin Enhances the Myometrial Contraction Through MT2‐PKC‐NRF2/MAFF Signaling Pathway in Sows	13
Melatonin, Melatonin Receptors and Sleep: Moving Beyond Traditional Views	12
Melatonin and Seasonal Synchrony in Mammals	12
Melatonin receptor structure and signaling	12
Cross‐species single‐cell landscape of vertebrate pineal gland	12
Quality‐of‐life outcomes following topical melatonin application against acute radiation dermatitis in patients with early breast cancer: A double‐blind, randomized, placebo‐controlled trial	12
Direct Peritoneal Resuscitation and Melatonin in the Treatment of Abdominal Sepsis‐Induced Lung Injury via Macrophage Metabolic Reprogramming	12
Melatonin functions as a broad‐spectrum antifungal by targeting a conserved pathogen protein kinase	12
Melatonin reduces brain injury following inflammation‐amplified hypoxia–ischemia in a translational newborn piglet study of neonatal encephalopathy	12
Histone deacetylase 9 regulates disease resistance through fine‐tuning histone deacetylation of melatonin biosynthetic genes and melatonin accumulation in cassava	12
Melatonin rescues the mitochondrial function of bone marrow‐derived mesenchymal stem cells and improves the repair of osteoporotic bone defect in ovariectomized rats	12
Dose assessment of melatonin in sepsis (DAMSEL2) study: Pharmacokinetics of two doses of oral melatonin in patients with sepsis	11
Coupling Melatonin and Ultrasound Modulates ROS Production, Antioxidant System, and Biochemical Attributes Linked to Oxidative Browning in Litchi Pericarp	11
Issue Information	11
Correction to “Effects of melatonin on fatty liver disease: The role of NR4A1/DNA‐PKcs/p53 pathway, mitochondrial fission, and mitophagy”	11
Melatonin alleviates myocardial dysfunction through inhibition of endothelial‐to‐mesenchymal transition via the NF‐κB pathway	11
Issue Information	11
Issue Information	11
OPA1 Mediated Fatty Acid β‐Oxidation in Hepatocyte: The Novel Insight for Melatonin Attenuated Apoptosis in Concanavalin A Induced Acute Liver Injury	11
Melatonin‐mediated malic enzyme 2 orchestrates mitochondrial fusion and respiratory functions to promote odontoblastic differentiation during tooth development	11
Key Role of the CRE Sequence in the Per1 Promoter in Mediating the Switch Between Unipolar and Bipolar Depression‐Like Behaviors	11
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Melatonin facts: Lack of evidence that melatonin is a radical scavenger in living systems	10
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Melatonin Is Bound to a Glycolytic Protein Complex via Tdh2p During Fermentation in Saccharomyces cerevisiae	10
Evening chronotype is associated with hormonal and metabolic disorders in polycystic ovary syndrome	10
Melatonin Alleviates Oxidative Stress‐Induced Mitochondrial Dysfunction Through Ameliorating NAD + Homeostasis of hDPSCs for Cell‐Based Therapy	10
Melatonin Overcomes Cancer Multidrug Resistance by Downregulating ABCB1 Expression and Modulating Mitochondrial Function	10
RETRACTION: Melatonin Modulates Dysregulated Circadian Clocks in Mice With Diethylnitrosamine‐Induced Hepatocellular Carcinoma	10
Circadian‐Related Serotonin/Melatonin Level Modulates Cisplatin Ototoxicity Susceptibility Depended on NOS3–NO Pathway	9
RETRACTION: Melatonin Induces Cell Cycle Arrest and Apoptosis in Hepatocarcinoma HepG2 Cell Line	9
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EXPRESSION OF CONCERN: Melatonin Protects Against Isoproterenol‐Induced Alterations in Cardiac Mitochondrial Energy‐Metabolizing Enzymes, Apoptotic Proteins, and Assists in Complete Recovery From Myoc	9
Correction to “Melatonin Antagonizes Cadmium‐Induced Neurotoxicity By Activating the Transcription Factor Eb‐Dependent Autophagy–Lysosome Machinery in Mouse Neuroblastoma Cells”	9
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Issue Information	9
Biosynthesis of neuroprotective melatonin is dysregulated in Huntington's disease	8
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RETRACTION: Melatonin Inhibits the Sphingosine Kinase 1/Sphingosine‐1‐Phosphate Signaling Pathway in Rabbits With Fulminant Hepatitis of Viral Origin	8
Protective Activity of Melatonin Combinations and Melatonin‐Based Hybrid Molecules in Neurodegenerative Diseases	8
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Correction to “PP2C1 Fine‐Tunes Melatonin Biosynthesis and Phytomelatonin Receptor PMTR1 Binding to Melatonin in Cassava”	8
Identification of a COMT Gene Involved in the Biosynthesis of Melatonin Which Mediates Resistance to Citrus Canker	8
Identification of Predictors of Shift Work Adaptation and Its Association With Immune, Hormonal and Metabolite Biomarkers	8
Multiaxial Biophysical Control of Oncogenic Phase Separation by Indoleamines: A Proof‐of‐Concept Synthesis of Landscape‐Level Regulation	8
Corrigendum to “melatonin ameliorates PM2.5‐induced cardiac perivascular fibrosis through regulating mitochondrial redox homeostasis”	8
Primary Gamma Knife Radiosurgery for pineal region tumors: A systematic review and pooled analysis of available literature with histological stratification	8
Delayed circadian rhythms in older Africans living with human immunodeficiency virus (HIV)	7
Meditation Linked to Enhanced MRI Signal Intensity in the Pineal Gland and Reduced Predicted Brain Age	7
Ramelteon for delirium prevention in hospitalized patients: An updated meta‐analysis and trial sequential analysis of randomized controlled trials	7
Melatonin ameliorates myocardial infarction in obese diabetic individuals: The possible involvement of macrophage apoptotic factors	7
RP58 knockdown contributes to hypoxia‐ischemia‐induced pineal dysfunction and circadian rhythm disruption in neonatal rats	7
Light and Temperature Coordinately Regulate Phytomelatonin Synthesis to Maintain Plant Morphogenesis via the COP1‐HY5 Module	7
Melatonin Influences Bmi1 + Intestinal Stem Cell Fate Through Metabolic Regulation After Irradiation	7
Design, Synthesis, and Antifungal Activity of Melatonin Derivatives Containing a (Thio)Semicarbazide Group	7
Mechanism of Exogenous Melatonin to Alleviate the Fermentation Performance of Saccharomyces cerevisiae Under Copper Stress	7
Melatonin: A Potential Therapy for Osteoporosis With Insights Into Molecular Mechanisms	6
Novel melatonin‐producing Bacillus safensis EH143 mitigates salt and cadmium stress in soybean	6
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Chronic developmental hypoxia alters mitochondrial oxidative capacity and reactive oxygen species production in the fetal rat heart in a sex‐dependent manner	6
Melatonin Protects Against Colistin‐Induced Intestinal Inflammation and Microbiota Dysbiosis	6
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Melatonin improves cardiac remodeling and brain–heart sympathetic hyperactivation aggravated by light disruption after myocardial infarction	6
Proteomic Signatures Underlying Sleep, Circadian Activity Patterns, and Major Chronic Diseases	6
Functional Characterization of GNA1 as a Serotonin N ‐Acetyltransferase Reveals a Key Role in the Serotonin to Melatonin Pathway in <	5
EXPRESSION OF CONCERN: Melatonin Protects Against Endometriosis via Regulation of Matrix Metalloproteinase‐3 and an Apoptotic Pathway	5
The ISL LIM‐homeobox 2 transcription factor is negatively regulated by circadian adrenergic signaling to repress the expression of Aanat in pinealocytes of the rat pineal gland	5
Issue Information	5
In vitro deacetylation of N‐acetylserotonin by arylacetamide deacetylase	5
Combinatory Effects of Indoximod and Melatonin Alleviate Myeloid Derived Suppressor Cells Driven Triple Negative Breast Cancer Progression and Metastasis	5
RETRACTION: Melatonin Prevents Deregulation of the Sphingosine Kinase/Sphingosine 1‐Phosphate Signaling Pathway in a Mouse Model of Diethylnitrosamine‐Induced Hepatocellular Carcinoma	5
EXPRESSION OF CONCERN: Melatonin Potentiates the Antiproliferative and Pro‐Apoptotic Effects of Ursolic Acid in Colon Cancer Cells by Modulating Multiple Signaling Pathways	5
Melatonin drives apoptosis in head and neck cancer by increasing mitochondrial ROS generated via reverse electron transport	5
Melatonin Repairs the Lipidome of Human Hepatocytes Exposed to Cd and Free Fatty Acid‐Induced Lipotoxicity	5
Resetting of the Human Circadian Melatonin Rhythm by Ambient Hypoxia	5
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Brain‐Targeted RVG‐Liposomal Melatonin Ameliorates Manganese Neurotoxicity by Enhancing Neurogenesis and Modulating Systemic Amino Acid Profiles	4
Melatonin Enhances Aquaporin 4 and Alpha‐Syntrophin Interaction by Inhibiting Cyclin‐Dependent Kinase 5 Activity to Preserve Glymphatic Function in Neonatal Hypoxic‐Ischemic Encephalopathy	4
Melatonin alleviates PM2.5‐induced glucose metabolism disorder and lipidome alteration by regulating endoplasmic reticulum stress	4
Exogenous Melatonin Enhances Waterlogging Tolerance in Sesame by Modulating Physiological, Biochemical, and Proteomic Responses	4
RETRACTION: Melatonin Attenuates Apoptotic Liver Damage in Fulminant Hepatic Failure Induced by the Rabbit Hemorrhagic Disease Virus	4
Correction to “Melatonin Promotes the Proliferation of Primordial Germ Cell‐Like Cells Derived From Porcine Skin‐Derived Stem Cells: A Mechanistic Analysis”	4
Melatonin Improves Diabetic‐Accelerated Experimental Osteoarthritis by Inhibiting NLRP3‐Mediated Chondrocyte Pyroptosis via PKG/Nrf2	4
Relationship Between Melatonin Receptor Agonists and Parkinson's Disease	4
Issue Information	4
Correction to “Melatonin Inhibits Cd4+ T Cell Apoptosis via the Bcl‐2/BAX Pathway and Improves Survival Rates in Mice With Sepsis”	4
Melatonin Prevents Thioacetamide–Induced Gut Leakiness and Liver Fibrosis Through the Gut–Liver Axis via Modulating Sirt1‐Related Deacetylation of Gut Junctional Complex and Hepatic Proteins	4
Rational modification of melatonin for broad‐spectrum antifungal agents discovery	4
N1‐Acetyl‐5‐methoxykynuramine, which decreases in the hippocampus with aging, improves long‐term memory via CaMKII/CREB phosphorylation	3
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Melatonin Promotes the Synthesis and Secretion of Growth Hormone in the Adenohypophysis by Activating the cAMP/FOXO1 Pathway	3
Manipulation of the Expression of SNAT1 Enhances Melatonin Biosynthesis, Promotes Plant Growth, and Improves Salt Stress Tolerance in Kiwifruit	3
EXPRESSION OF CONCERN: Melatonin Alleviates Brain Injury in Mice Subjected to Cecal Ligation and Puncture via Attenuating Inflammation, Apoptosis, and Oxidative Stress: The Role of SIRT1 Signaling	3
Industrial and academic approaches to the search for alternative melatonin receptor ligands: An historical survey	3
Circadian Rhythm Timing and Associations With Sleep Symptoms in People With Insomnia	3
RETRACTION: Regulation of Prostaglandin Production in Carrageenan‐Induced Pleurisy Melatonin	3
Healthy Lifestyles Modify the Association of Melatonin Receptor 1B Gene and Ischemic Stroke: A Family‐Based Cohort Study in Northern China	3
Sleep Deprivation Exacerbates High‐Fat Diet‐Induced Obesity and MAFLD Through Melatonin Reduction Mediated NF‐κB Activation	3
Modeling Genetic Risk of β‐Cell Dysfunction in Human Induced Pluripotent Stem Cells From Patients Carrying the MTNR1B Risk Variant	3
EXPRESSION OF CONCERN: Matrix Metalloproteinase‐9 Activity and Expression Is Reduced by Melatonin During Prevention of Ethanol‐Induced Gastric Ulcer in Mice	3
Adrenergic Agonists Activate Transcriptional Activity in Immortalized Neuronal Cells From the Mouse Suprachiasmatic Nucleus	3
Safety and efficacy of melatonin supplementation as an add‐on treatment for infantile epileptic spasms syndrome: A randomized, placebo‐controlled, double‐blind trial	3
Shift and longtime light induces endometrioid adenocarcinoma via activation of PKC‐α/Akt pathway in female golden hamster: Involvement of altered Aanat and Bmal1 rhythm	3
Melatonin suppression by light involves different retinal photoreceptors in young and older adults	3
EXPRESSION OF CONCERN: Mechanisms of Isoproterenol‐Induced Cardiac Mitochondrial Damage: Protective Actions of Melatonin	3
Discovery Begets Discovery: Special Edition on Melatonin and the Musculoskeletal System	3
Ramelteon attenuates hippocampal neuronal loss and memory impairment following kainate‐induced seizures	3