Journal of Pineal Research

Article	Citations
Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation	182
Melanopic illuminance defines the magnitude of human circadian light responses under a wide range of conditions	133
Melatonin attenuates diabetic cardiomyopathy and reduces myocardial vulnerability to ischemia‐reperfusion injury by improving mitochondrial quality control: Role of SIRT6	108
Melatonin attenuates choroidal neovascularization by regulating macrophage/microglia polarization via inhibition of RhoA/ROCK signaling pathway	99
Deletion of ferritin H in neurons counteracts the protective effect of melatonin against traumatic brain injury‐induced ferroptosis	99
Melatonin protects mouse testes from palmitic acid‐induced lipotoxicity by attenuating oxidative stress and DNA damage in a SIRT1‐dependent manner	97
Melatonin confers cadmium tolerance by modulating critical heavy metal chelators and transporters in radish plants	89
Circadian rhythms and obesity: Timekeeping governs lipid metabolism	81
Melatonin ameliorates cognitive deficits through improving mitophagy in a mouse model of Alzheimer’s disease	71
Melatonin inhibits seed germination by crosstalk with abscisic acid, gibberellin, and auxin in Arabidopsis	62
Extracellular vesicles derived from melatonin‐preconditioned mesenchymal stem cells containing USP29 repair traumatic spinal cord injury by stabilizing NRF2	59
Measuring melatonin by immunoassay	57
Melatonin reshapes the mitochondrial network and promotes intercellular mitochondrial transfer via tunneling nanotubes after ischemic‐like injury in hippocampal HT22 cells	54
Clinical trial to test the efficacy of melatonin in COVID‐19	53
Melatonin mitigates aflatoxin B1‐induced liver injury via modulation of gut microbiota/intestinal FXR/liver TLR4 signaling axis in mice	48
Melatonin inhibits lung cancer development by reversing the Warburg effect via stimulating the SIRT3/PDH axis	47
Melatonin restores neutrophil functions and prevents apoptosis amid dysfunctional glutathione redox system	46
Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans	46
Melatonin effects on bone: Implications for use as a therapy for managing bone loss	44
Melatonin ameliorates PM2.5‐induced cardiac perivascular fibrosis through regulating mitochondrial redox homeostasis	43
A novel melatonin‐regulated lncRNA suppresses TPA‐induced oral cancer cell motility through replenishing PRUNE2 expression	43
Safety of higher doses of melatonin in adults: A systematic review and meta‐analysis	43
Melatonin improves the effect of cryopreservation on human oocytes by suppressing oxidative stress and maintaining the permeability of the oolemma	41
Melatonin receptor ligands: A pharmaco‐chemical perspective	39
Melatonin reduces nanoplastic uptake, translocation, and toxicity in wheat	38

Weekly, seasonal, and chronotype‐dependent variation of dim‐light melatonin onset	36
Melatonin mitigates disrupted circadian rhythms, lowers intraocular pressure, and improves retinal ganglion cells function in glaucoma	36
Melatonin ameliorates aortic valve calcification via the regulation of circular RNA CircRIC3/miR‐204‐5p/DPP4 signaling in valvular interstitial cells	36
Melatonin directly binds and inhibits death‐associated protein kinase 1 function in Alzheimer’s disease	35
Melatonin controversies, an update	35
Predicting melatonin suppression by light in humans: Unifying photoreceptor‐based equivalent daylight illuminances, spectral composition, timing and duration of light exposure	34
Melatonin protects against thoracic aortic aneurysm and dissection through SIRT1‐dependent regulation of oxidative stress and vascular smooth muscle cell loss	34
Changing color and intensity of LED lighting across the day impacts on circadian melatonin rhythms and sleep in healthy men	34
A meta‐analysis of microRNA networks regulated by melatonin in cancer: Portrait of potential candidates for breast cancer treatment	31
The interplay between mast cells, pineal gland, and circadian rhythm: Links between histamine, melatonin, and inflammatory mediators	30
Melatonin and other indoles show antiviral activities against swine coronaviruses in vitro at pharmacological concentrations	29
Melatonin protects inner retinal neurons of newborn mice after hypoxia‐ischemia	29
Melatonin restores the pluripotency of long‐term‐cultured embryonic stem cells through melatonin receptor‐dependent m6A RNA regulation	28
Melatonin reduces proliferation and promotes apoptosis of bladder cancer cells by suppressing O‐GlcNAcylation of cyclin‐dependent‐like kinase 5	28
The dual roles of melatonin biosynthesis enzymes in the coordination of melatonin biosynthesis and autophagy in cassava	28
Whole‐genome sequence data of Hypericum perforatum and functional characterization of melatonin biosynthesis by N‐acetylserotonin O‐methyltransferase	27
Melatonin and verteporfin synergistically suppress the growth and stemness of head and neck squamous cell carcinoma through the regulation of mitochondrial dynamics	27
Modeling melanopsin‐mediated effects of light on circadian phase, melatonin suppression, and subjective sleepiness	27
Switching diseased cells from cytosolic aerobic glycolysis to mitochondrial oxidative phosphorylation: A metabolic rhythm regulated by melatonin?	27
The association between melatonin and episodic migraine: A pilot network meta‐analysis of randomized controlled trials to compare the prophylactic effects with exogenous melatonin supplementation and	27
Melatonin‐triggered post‐transcriptional and post‐translational modifications of ADAMTS1 coordinately retard tumorigenesis and metastasis of renal cell carcinoma	27
S‐cone contribution to the acute melatonin suppression response in humans	27
Melatonin improves uterine‐conceptus interaction via regulation of SIRT1 during early pregnancy	27
Melatonin synthesis genes N‐acetylserotonin methyltransferases evolved into caffeic acid O‐methyltransferases and both assisted in plant terrestrialization	26
Pan‐cancer analyses reveal genomics and clinical characteristics of the melatonergic regulators in cancer	25
Revisiting the role of melatonin in human melanocyte physiology: A skin context perspective	25
Melatonin drives apoptosis in head and neck cancer by increasing mitochondrial ROS generated via reverse electron transport	24
Melatonin may suppress lung adenocarcinoma progression via regulation of the circular noncoding RNA hsa_circ_0017109/miR‐135b‐3p/TOX3 axis	24
Journal of Pineal Research guideline for authors: Measuring melatonin in humans	24
The melatonin metabolite N1‐acetyl‐5‐methoxykynuramine facilitates long‐term object memory in young and aging mice	23
Early chronotype with advanced activity rhythms and dim light melatonin onset in a rural population	23
Melatonin delays dark‐induced leaf senescence by inducing miR171b expression in tomato	23
Anti‐PANoptosis is involved in neuroprotective effects of melatonin in acute ocular hypertension model	23
Single‐cell transcriptomic analysis reveals circadian rhythm disruption associated with poor prognosis and drug‐resistance in lung adenocarcinoma	22
The potential remedy of melatonin on osteoarthritis	22
Exogenous melatonin decreases circadian misalignment and body weight among early types	21
Treatment of isolated REM sleep behavior disorder using melatonin as a chronobiotic	20
Melatonin promotes regeneration of injured motor axons via MT1 receptors	20
The phytomelatonin receptor PMTR1 regulates seed development and germination by modulating abscisic acid homeostasis in Arabidopsis thaliana	20
Melatonin rescues the reproductive toxicity of low‐dose glyphosate‐based herbicide during mouse oocyte maturation via the GPER signaling pathway	20
Recharge of chondrocyte mitochondria by sustained release of melatonin protects cartilage matrix homeostasis in osteoarthritis	20
High sensitivity of melatonin suppression response to evening light in preschool‐aged children	19
In‐person vs home schooling during the COVID‐19 pandemic: Differences in sleep, circadian timing, and mood in early adolescence	19
Therapeutic potential of melatonin and melatonergic drugs on K18‐hACE2 mice infected with SARS‐CoV‐2	19
Mitochondrial function is controlled by melatonin and its metabolites in vitro in human melanoma cells	19
Robust stability of melatonin circadian phase, sleep metrics, and chronotype across months in young adults living in real‐world settings	18
Melatonin alleviates the heat stress‐induced impairment of Sertoli cells by reprogramming glucose metabolism	18
Melatonin mediates reactive oxygen species homeostasis via SlCV to regulate leaf senescence in tomato plants	17
Dysfunction of serotonergic activity and emotional responses across the light‐dark cycle in mice lacking melatonin  MT2 receptors	17
Melatonin functions as a broad‐spectrum antifungal by targeting a conserved pathogen protein kinase	17

Melatonin modulates Nrf2 activity to protect porcine pre‐pubertal Sertoli cells from the abnormal H2O2 generation and reductive stress effects of cadmium	17
Melatonin promotes potassium deficiency tolerance by regulating HAK1 transporter and its upstream transcription factor NAC71 in wheat	17
Melatonin and the health of menopausal women: A systematic review	17
Melatonin reverses the loss of the anticontractile effect of perivascular adipose tissue in obese rats	17
Disrupted nocturnal melatonin in autism: Association with tumor necrosis factor and sleep disturbances	17
Melatonin pretreatment alleviates the long‐term synaptic toxicity and dysmyelination induced by neonatal Sevoflurane exposure via MT1 receptor‐mediated Wnt signaling modulation	16
Nociceptive responses in melatonin MT2 receptor knockout mice compared to MT1 and double MT1/MT2 receptor knockout mice	16
Resource: A multi‐species multi‐timepoint transcriptome database and webpage for the pineal gland and retina	15
Fine‐tuning of pathogenesis‐related protein 1 (PR1) activity by the melatonin biosynthetic enzyme ASMT2 in defense response to cassava bacterial blight	15
Impact of endogenous melatonin on rhythmic behaviors, reproduction, and survival revealed in melatonin‐proficient C57BL/6J congenic mice	15
Decreased melatonin secretion in patients with glaucoma: Quantitative association with glaucoma severity in the LIGHT study	15
Acute metabolic effects of melatonin—A randomized crossover study in healthy young men	14
High dose melatonin increases sleep duration during nighttime and daytime sleep episodes in older adults	14
PP2C1 fine‐tunes melatonin biosynthesis and phytomelatonin receptor PMTR1 binding to melatonin in cassava	14
Chronic developmental hypoxia alters mitochondrial oxidative capacity and reactive oxygen species production in the fetal rat heart in a sex‐dependent manner	14
Melatonin modulates metabolic remodeling in HNSCC by suppressing MTHFD1L‐formate axis	14
Melatonin multifaceted pharmacological actions on melatonin receptors converging to abrogate COVID‐19	13
Genetic and evolutionary dissection of melatonin response signaling facilitates the regulation of plant growth and stress responses	13
A novel role for the pineal gland: Regulating seasonal shifts in the gut microbiota of Siberian hamsters	13
Tunneling nanotubes and mesenchymal stem cells: New insights into the role of melatonin in neuronal recovery	12
Enhanced anti‐angiogenic activity of novel melatonin‐like agents	12
The effect of melatonin on glucose tolerance, insulin sensitivity and lipid profiles after a late evening meal in healthy young males	12
Melatonin mediates elevated carbon dioxide‐induced photosynthesis and thermotolerance in tomato	12
Modulations in irradiance directed at melanopsin, but not cone photoreceptors, reliably alter electrophysiological activity in the suprachiasmatic nucleus and circadian behaviour in mice	12
Access to electric light is associated with delays of the dim‐light melatonin onset in a traditionally hunter‐gatherer Toba/Qom community	12
Activation of melatonin receptor 1 by CRISPR‐Cas9 activator ameliorates cognitive deficits in an Alzheimer's disease mouse model	12
Daytime light exposure is a strong predictor of seasonal variation in sleep and circadian timing of university students	11
Melatonin inhibits atherosclerosis progression via galectin‐3 downregulation to enhance autophagy and inhibit inflammation	11
Maternal melatonin: Effective intervention against developmental programming of cardiovascular dysfunction in adult offspring of complicated pregnancy	11
Cancer, hear my battle CRY	11
A classification approach to estimating human circadian phase under circadian alignment from actigraphy and photometry data	10
Melatonin inhibits endometriosis development by disrupting mitochondrial function and regulating tiRNAs	10
Melatonin suppresses the metastatic potential of osteoblastic prostate cancers by inhibiting integrin α2β1 expression	10
Deconstructing circadian disruption: Assessing the contribution of reduced peripheral oscillator amplitude on obesity and glucose intolerance in mice	10
Melatonin supplementation in the culture medium rescues impaired glucose metabolism in IVF mice offspring	10
Physiological consequences of space flight, including abnormal bone metabolism, space radiation injury, and circadian clock dysregulation: Implications of melatonin use and regulation as a countermeas	10
Angelman syndrome and melatonin: What can they teach us about sleep regulation	10
Cyclic uniaxial mechanical load enhances chondrogenesis through entraining the molecular circadian clock	10
Melatonin induces apoptotic cell death through Bim stabilization by Sp1‐mediated OTUD1 upregulation	10
Journal of pineal research guideline for authors: Defining and characterizing melatonin targets	10
Clock‐controlled arylalkylamine N‐acetyltransferase (aaNAT) regulates circadian rhythms of locomotor activity in the American cockroach, Periplaneta americana, via melatonin/MT2‐l	9
Melatonin for prevention of fetal lung injury associated with intrauterine inflammation and for improvement of lung maturation	9
Three months of melatonin treatment reduces insulin sensitivity in patients with type 2 diabetes—A randomized placebo‐controlled crossover trial	9
Melatonin augments the neuroprotective effects of hypothermia in lambs following perinatal asphyxia	9
Weekly and seasonal variation in the circadian melatonin rhythm in humans: Entrained to local clock time, social time, light exposure or sun time?	9
Single‐cell RNA sequencing of preadipocytes reveals the cell fate heterogeneity induced by melatonin	9
Melatonin recovers sleep phase delayed by MK‐801 through the melatonin MT2 receptor‐ Ca2+‐CaMKII‐CREB pathway in the ventrolateral preoptic nucleus	9
BPS‐induced ovarian dysfunction: Protective actions of melatonin via modulation of SIRT‐1/Nrf2/NFĸB and IR/PI3K/pAkt/GLUT‐4 expressions in adult golden hamster	9
Melatonin protects against developmental PBDE‐47 neurotoxicity by targeting the AMPK/mitophagy axis	8
Melatonin prevents experimental central serous chorioretinopathy in rats	8
Endogenous circadian regulation and phase resetting of clinical metabolic biomarkers	8
Melatonin and andrographolide synergize to inhibit the colospheroid phenotype by targeting Wnt/beta‐catenin signaling	8
Circadian photoperiod alters TREK‐1 channel function and expression in dorsal raphe serotonergic neurons via melatonin receptor 1 signaling	8
Melatonin improves cardiac remodeling and brain–heart sympathetic hyperactivation aggravated by light disruption after myocardial infarction	8
The Plasmodium falciparum eIK1 kinase (PfeIK1) is central for melatonin synchronization in the human malaria parasite. Melatotosil blocks melatonin action on parasite cell cycle	8
The role of MEK1/2 and MEK5 in melatonin‐mediated actions on osteoblastogenesis, osteoclastogenesis, bone microarchitecture, biomechanics, and bone formation	8
A hypothetical role for autophagy during the day/night rhythm‐regulated melatonin synthesis in the rat pineal gland	7
Relationship between locomotor activity rhythm and corticosterone levels during HCC development, progression, and treatment in a mouse model	7
Melatonin regulates maternal pancreatic remodeling and B‐cell function during pregnancy and lactation	7
Melatonin alleviates PM2.5‐induced glucose metabolism disorder and lipidome alteration by regulating endoplasmic reticulum stress	7
Photoperiod integration in C3H rd1 mice	7
Dynamic lighting schedules to facilitate circadian adaptation to shifted timing of sleep and wake	6
Supraspinal melatonin MT2 receptor agonism alleviates pain via a neural circuit that recruits mu opioid receptors	6
The role of homeobox gene‐encoded transcription factors in regulation of phototransduction: Implementing the primary pinealocyte culture as a photoreceptor model	6
Melatonin and aggressive behavior: A systematic review of the literature on preclinical and clinical evidence	6
A PERIOD3 variable number tandem repeat polymorphism modulates melatonin treatment response in delayed sleep‐wake phase disorder	6
Measuring morning melatonin levels with plasma melatonin ELISA kits is a poor choice on two levels	6
Dose assessment of melatonin in sepsis (DAMSEL2) study: Pharmacokinetics of two doses of oral melatonin in patients with sepsis	6
Melatonin ameliorates myocardial infarction in obese diabetic individuals: The possible involvement of macrophage apoptotic factors	5
Evening chronotype is associated with hormonal and metabolic disorders in polycystic ovary syndrome	5
The role of circadian phase in sleep and performance during Antarctic winter expeditions	5
Melatonin promotes the proliferation of primordial germ cell‐like cells derived from porcine skin‐derived stem cells: A mechanistic analysis	5
The pathway of melatonin biosynthesis in common wheat (Triticum aestivum)	5
Human–rat integrated microRNAs profiling identified a new neonatal cerebral hypoxic–ischemic pathway melatonin‐sensitive	5
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Unanticipated daytime melatonin secretion on a simulated night shift schedule generates a distinctive 24‐h melatonin rhythm with antiphasic daytime and nighttime peaks	5
Melatonin improves skin barrier damage caused by sleep restriction through gut microbiota	5
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Ramelteon for delirium prevention in hospitalized patients: An updated meta‐analysis and trial sequential analysis of randomized controlled trials	4
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Weekly and seasonal variation in the circadian melatonin rhythm in humans: A response	4
Delayed circadian rhythms in older Africans living with human immunodeficiency virus (HIV)	4
Daytime rest: Association with 24‐h rest–activity cycles, circadian timing and cognition in older adults	4
N‐Acetylserotonin is an oxidation‐responsive activator of Nrf2 ameliorating colitis in rats	4
Effects of dynamic lighting on circadian phase, self‐reported sleep and performance during a 45‐day space analog mission with chronic variable sleep deficiency	4
Genetic ablation of the Bsx homeodomain transcription factor in zebrafish: Impact on mature pineal gland morphology and circadian behavior	4
ABCG2 transporter plays a key role in the biodistribution of melatonin and its main metabolites	4
Melatonin restores endoplasmic reticulum homeostasis to protect injured neurons in a rat model of chronic cervical cord compression	4