OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Pineal Research is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
A phase II, single‐center, double‐blind, randomized placebo‐controlled trial to explore the efficacy and safety of intravenous melatonin in surgical patients with severe sepsis admitted to the intensi	98
Correction to high sensitivity of melatonin suppression response to evening light in preschool‐aged children	84
RETRACTION: Changes in the Expression of Melatonin Receptors Induced by Melatonin Treatment in Hepatocarcinoma HepG2 Cells	77
Zygotic Exposure to Venlafaxine Disrupts the Circadian Locomotor Activity Behaviour in Zebrafish Larvae	75
Corrigendum to Melatonin Attenuates D‐Galactose‐Induced Memory Impairment, Neuroinflammation and Neurodegeneration via Rage/Nf‐ _K B/Jnk Signaling Pat	73
Melatonin as a chronobiotic/cytoprotective agent in bone. Doses involved	62
Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications	58
Melatonin targets MoIcl1 and works synergistically with fungicide isoprothiolane in rice blast control	58
Microbial Melatonin Production Improves Plant Metabolic Function in Short‐Term Climate‐Induced Stresses	57
Melatonin Increased Autophagy Level to Facilitate Osteogenesis of Inflamed PDLSCs Through TMEM110 Signaling Pathways	52
Melatonin inhibits chondrosarcoma cell proliferation and metastasis by enhancing miR‐520f‐3p production and suppressing MMP7 expression	50
Transcriptomic and Metabolomic Signatures of Acute Circadian Misalignment in Mice	48
BPS‐induced ovarian dysfunction: Protective actions of melatonin via modulation of SIRT‐1/Nrf2/NFĸB and IR/PI3K/pAkt/GLUT‐4 expressions in adult golden hamster	45
From Seasonality to Species Conservation: Chronobiological Research on European Hamsters in Strasbourg, France	44
Issue Information	43
Melatonin Ameliorates Atherosclerotic Plaque Vulnerability by Regulating PPARδ‐Associated Smooth Muscle Cell Phenotypic Switching	42
	41
Erratum to: Mitochondrial cytochrome P450 (CYP) 1B1 is responsible for melatonin‐induced apoptosis in neural cancer cells	41
Issue Information	40
Melatonin Enhances Peanut Productivity by Enriching Root‐Associated Nitrogen‐Fixing Bacteria	38
Exogenous Melatonin Regulates Hormone Signalling and Photosynthesis‐Related Genes to Enhance Brassica napus. Yield: A Transcriptomic Perspective	36
EXPRESSION OF CONCERN: Melatonin Prevents Cadmium‐Induced Bone Damage: First Evidence on an Improved Osteogenic/Adipogenic Differentiation Balance of Mesenchymal Stem Cells as Underlying Mechanism	36
Light‐Dependent Circadian Rhythm Governs O‐GlcNAc Cycling to Influence Cognitive Function in Adult Zebrafish	36
Anti‐PANoptosis is involved in neuroprotective effects of melatonin in acute ocular hypertension model	35
Investigating the safety profiles of exogenous melatonin and associated adverse events: A pharmacovigilance study using WHO‐VigiBase	34

Optimizing the Time and Dose of Melatonin as a Sleep‐Promoting Drug: A Systematic Review of Randomized Controlled Trials and Dose−Response Meta‐Analysis	33
3‐Month Melatonin Supplementation to Reduce Brain Oxidative Stress and Improve Sleep in Mild Cognitive Impairment: A Randomised Controlled Feasibility Trial	32
From gestational chronodisruption to noncommunicable diseases: Pathophysiological mechanisms of programming of adult diseases, and the potential therapeutic role of melatonin	32
RETRACTION: Melatonin Suppresses Proinflammatory Mediators in Lipopolysaccharide‐Stimulated CRL1999 Cells via Targeting MAPK, NF‐κB, c/EBPβ, and p300 Signaling	31
	31
Correction to “Melatonin mediates selenium‐induced tolerance to cadmium stress in tomato plants”	28
RETRACTION: Melatonin Inhibits the Expression of the Inducible Isoform of Nitric Oxide Synthase and Nuclear Factor Kappa B Activation in Rat Skeletal Muscle	28
Melatonin prevents EAAC1 deletion‐induced retinal ganglion cell degeneration by inhibiting apoptosis and senescence	27
Melatonin improves skin barrier damage caused by sleep restriction through gut microbiota	25
RETRACTION: Inhibiting MT2‐TFE3‐Dependent Autophagy Enhances Melatonin‐Induced Apoptosis in Tongue Squamous Cell Carcinoma	24
Relationship Between Urinary 6‐Sulfatoxymelatonin Rhythms and the Bone Resorption Marker Amino‐Terminal Cross‐Linked Telopeptide of Collagen I in Blind Women	23
Correction to “Identification, Transcriptional and Functional Analysis of Heat‐Shock Protein 90s in Banana ( Musa acuminata L.) Highlight Their Novel Rol	23
Light Environment of Arctic Solstices is Coupled With Melatonin Phase‐Amplitude Changes and Decline of Metabolic Health	23
Homeobox gene‐encoded transcription factors in development and mature circadian function of the rodent pineal gland	22
Effect of melatonin cream on acute radiation dermatitis in patients with primary breast cancer: A double‐blind, randomized, placebo‐controlled trial	22
Effect of melatonin on ATG2B‐mediated autophagy regulation in sheep granulosa cells with different Fec^B genotypes	22
Cover image	22
EXPRESSION OF CONCERN: Mitochondrial Function Is Controlled by Melatonin and Its Metabolites In Vitro in Human Melanoma Cells	22
Issue Information	22
Melatonin Defends Against the Oxidative Stress by Preventing the Uptake of Nanoplastics and Activating the Antioxidant System in Paeonia ostii	21
Orphan GPR50 Restrains Neurite Outgrowth and Cell Migration by Activating the G_12/13 Protein‐RhoA Pathway in Neural Progenitor Cells and Tanycytes	21
Multi‐Omics Analysis Reveals That AhNHL Contributes to Melatonin‐Mediated Cadmium Tolerance in Peanut Plants	21
Melatonin Ameliorates Circadian Disruption‐Associated Dry Eye via Modulation of BMAL1‐REV‐ERBα‐IL‐17 Axis and Ocular Surface Microbiota Homeostasis	21
Correction to “Melatonin Attenuated Early Brain Injury Induced by Subarachnoid Hemorrhage via Regulating NLRP3 Inflammasome and Apoptosis Signaling”	20
Melatonin Rescues Influenza A Virus–Induced Cellular Energy Exhaustion via OMA1‐OPA1‐S in Acute Exacerbation of COPD	20
In Vitro and In Vivo Effects of Melatonin‐Containing Combinations in Human Pancreatic Ductal Adenocarcinoma	20
	19
Relating Photoperiod and Outdoor Temperature With Sleep Architecture in Patients With Neuropsychiatric Sleep Disorders	19
Cover image	19
Protective Effects of Melatonin on Kidney Function Against Contrast Media‐Induced Kidney Damage in Patients With Chronic Kidney Disease: A Prospective, Randomized, Double‐Blinded, Placebo‐Controlled T	18
Melatonin Alleviates Osteoarthritis by Regulating NADPH Oxidase 4–Induced Ferroptosis and Mitigating Mitochondrial Dysfunction	18
Melatonin as a key regulator in seed germination under abiotic stress	18
Mouse Models in Circadian Rhythm and Melatonin Research	18
Melatonin Membrane Receptors in the Vascular System: Function, Modulation and Clinical Relevance	18
Melatonin‐Mediated Alleviation of Plant Response to Heavy Metals: From Integrative Mechanisms to Potential Applications	18
NPAS2 Deficiency Leads to Antidepressant‐Like Behaviors in Mice by Modulating Astrocyte‐Mediated Neuroinflammation	17
IAT4 , a New Indolamine N ‐Acetyltransferase in Saccharomyces cerevisiae Involv	17
Melatonin Affects Peucedanum praeruptorum Vegetative Growth and Coumarin Synthesis by Modulating the Antioxidant System, Photosynthesis, and Endogenous H	17
Correction to “Melatonin/PGC1A/UCP1 promotes tumor slimming and represses tumor progression by initiating autophagy and lipid browning”	17
	17
Melatonin and Exercise Restore Myogenesis and Mitochondrial Dynamics Deficits Associated With Sarcopenia in iMS‐ Bmal1 ^−/−	16
Thirty‐seven years of MT1 and MT2 melatonin receptor localization in the brain: Past and future challenges	16
Cyclic uniaxial mechanical load enhances chondrogenesis through entraining the molecular circadian clock	16
Melatonin, an Antitumor Necrosis Factor Therapy	16
The Mechanism by Which Melatonin Improves the Dysregulation of Glucose and Lipid Metabolism in Castrated Female Mice	16
Melatonin Inhibits Endometriosis Growth via Specific Binding and Inhibition of EGFR Phosphorylation	16
Melatonin protects against developmental PBDE‐47 neurotoxicity by targeting the AMPK/mitophagy axis	16
Melatonin sensitizes leukemia cells to the MCL1 inhibitors S63845 and A‐1210477 through multiple pathways	16
Melatonin inhibits endometriosis development by disrupting mitochondrial function and regulating tiRNAs	15
Correction to “Melatonin Mediates Elevated Carbon Dioxide‐Induced Photosynthesis and Thermotolerance in Tomato”	15

Melatonin Regulates Rheumatoid Synovial Fibroblasts‐Related Inflammation: Implications for Pathological Skeletal Muscle Treatment	15
Melatonin MT1 receptors regulate the Sirt1/Nrf2/Ho‐1/Gpx4 pathway to prevent α‐synuclein‐induced ferroptosis in Parkinson's disease	15
Hypnotic effects of melatonin depend on the environmental lighting conditions in the rat	15
Time‐of‐Day Impacts Uterine Circadian Rhythms and Response to Oxytocin: Comparison of Uterine Function in Melatonin‐Deficient C57BL/6 Versus Melatonin Proficient CBA/B6 Hybrid Mice	15
RETRACTION: Melatonin Inhibits Autophagy and Endoplasmic Reticulum Stress in Mice With Carbon Tetrachloride‐Induced Fibrosis	15
Cover image	15
Greater sensitivity of the circadian system of women to bright light, but not dim‐to‐moderate light	14
Cover image	14
Zebrafish Dark‐Dependent Behavior Requires Phototransduction by the Pineal Gland	14
Melatonin Supplementation Alleviates Bone Mineral Density Decline and Circulating Oxidative Stress in Iron‐Overloaded Thalassemia Patients	14
Melatonin Regulates Neuronal Synaptic Plasticity in the Supramammillary Nucleus and Attenuates Methamphetamine‐Induced Conditioned Place Preference and Sensitization in Mice	14
	13
Melatonin Enhances the Myometrial Contraction Through MT2‐PKC‐NRF2/MAFF Signaling Pathway in Sows	13
KARS Mutations Impair Brain Myelination by Inducing Oligodendrocyte Deficiency: One Potential Mechanism and Improvement by Melatonin	13
Standardized and Calibrated Light Stimuli via Head‐Mounted Displays for Investigating the Nonvisual Effects of Light	13
Cover image	13
Criticism on the Incorrect Use of Oxygen–Ozone Therapy in Medicine	13
Melatonin reduces brain injury following inflammation‐amplified hypoxia–ischemia in a translational newborn piglet study of neonatal encephalopathy	12
Histone deacetylase 9 regulates disease resistance through fine‐tuning histone deacetylation of melatonin biosynthetic genes and melatonin accumulation in cassava	12
Melatonin rescues the mitochondrial function of bone marrow‐derived mesenchymal stem cells and improves the repair of osteoporotic bone defect in ovariectomized rats	12
Melatonin, Melatonin Receptors and Sleep: Moving Beyond Traditional Views	12
Melatonin and Seasonal Synchrony in Mammals	12
Melatonin receptor structure and signaling	12
Cross‐species single‐cell landscape of vertebrate pineal gland	12
Quality‐of‐life outcomes following topical melatonin application against acute radiation dermatitis in patients with early breast cancer: A double‐blind, randomized, placebo‐controlled trial	12
Direct Peritoneal Resuscitation and Melatonin in the Treatment of Abdominal Sepsis‐Induced Lung Injury via Macrophage Metabolic Reprogramming	12
Melatonin functions as a broad‐spectrum antifungal by targeting a conserved pathogen protein kinase	12