OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Pineal Research is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Melatonin Increased Autophagy Level to Facilitate Osteogenesis of Inflamed PDLSCs Through TMEM110 Signaling Pathways	129
RETRACTION: Changes in the Expression of Melatonin Receptors Induced by Melatonin Treatment in Hepatocarcinoma HepG2 Cells	92
Correction to high sensitivity of melatonin suppression response to evening light in preschool‐aged children	67
A phase II, single‐center, double‐blind, randomized placebo‐controlled trial to explore the efficacy and safety of intravenous melatonin in surgical patients with severe sepsis admitted to the intensi	66
Melatonin mediates reactive oxygen species homeostasis via SlCV to regulate leaf senescence in tomato plants	53
Zygotic Exposure to Venlafaxine Disrupts the Circadian Locomotor Activity Behaviour in Zebrafish Larvae	50
BPS‐induced ovarian dysfunction: Protective actions of melatonin via modulation of SIRT‐1/Nrf2/NFĸB and IR/PI3K/pAkt/GLUT‐4 expressions in adult golden hamster	49
Microbial Melatonin Production Improves Plant Metabolic Function in Short‐Term Climate‐Induced Stresses	47
Melatonin inhibits chondrosarcoma cell proliferation and metastasis by enhancing miR‐520f‐3p production and suppressing MMP7 expression	47
Transcriptomic and Metabolomic Signatures of Acute Circadian Misalignment in Mice	46
Melatonin targets MoIcl1 and works synergistically with fungicide isoprothiolane in rice blast control	46
Melatonin as a chronobiotic/cytoprotective agent in bone. Doses involved	45
Erratum to: Mitochondrial cytochrome P450 (CYP) 1B1 is responsible for melatonin‐induced apoptosis in neural cancer cells	43
From Seasonality to Species Conservation: Chronobiological Research on European Hamsters in Strasbourg, France	42
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Issue Information	40
Melatonin Ameliorates Atherosclerotic Plaque Vulnerability by Regulating PPARδ‐Associated Smooth Muscle Cell Phenotypic Switching	39
Issue Information	38
Exogenous Melatonin Regulates Hormone Signalling and Photosynthesis‐Related Genes to Enhance Brassica napus. Yield: A Transcriptomic Perspective	37
Investigating the safety profiles of exogenous melatonin and associated adverse events: A pharmacovigilance study using WHO‐VigiBase	36
Optimizing the Time and Dose of Melatonin as a Sleep‐Promoting Drug: A Systematic Review of Randomized Controlled Trials and Dose−Response Meta‐Analysis	34
Light‐Dependent Circadian Rhythm Governs O‐GlcNAc Cycling to Influence Cognitive Function in Adult Zebrafish	34
Anti‐PANoptosis is involved in neuroprotective effects of melatonin in acute ocular hypertension model	34
RETRACTION: Melatonin Inhibits the Expression of the Inducible Isoform of Nitric Oxide Synthase and Nuclear Factor Kappa B Activation in Rat Skeletal Muscle	33
Melatonin prevents EAAC1 deletion‐induced retinal ganglion cell degeneration by inhibiting apoptosis and senescence	31

Correction to “Melatonin mediates selenium‐induced tolerance to cadmium stress in tomato plants”	30
Melatonin treatment improves ventricular conduction via upregulation of Nav1.5 channel proteins and sodium current in the normal rat heart	30
Relationship Between Urinary 6‐Sulfatoxymelatonin Rhythms and the Bone Resorption Marker Amino‐Terminal Cross‐Linked Telopeptide of Collagen I in Blind Women	29
No association between a common type 2 diabetes risk gene variant in the melatonin receptor gene (MTNR1B) and mortality among type 2 diabetes patients	29
Effect of melatonin cream on acute radiation dermatitis in patients with primary breast cancer: A double‐blind, randomized, placebo‐controlled trial	29
3‐Month Melatonin Supplementation to Reduce Brain Oxidative Stress and Improve Sleep in Mild Cognitive Impairment: A Randomised Controlled Feasibility Trial	27
Melatonin improves skin barrier damage caused by sleep restriction through gut microbiota	27
From gestational chronodisruption to noncommunicable diseases: Pathophysiological mechanisms of programming of adult diseases, and the potential therapeutic role of melatonin	26
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Light Environment of Arctic Solstices is Coupled With Melatonin Phase‐Amplitude Changes and Decline of Metabolic Health	25
Issue Information	25
Predicting melatonin suppression by light in humans: Unifying photoreceptor‐based equivalent daylight illuminances, spectral composition, timing and duration of light exposure	25
Homeobox gene‐encoded transcription factors in development and mature circadian function of the rodent pineal gland	24
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Melatonin Rescues Influenza A Virus–Induced Cellular Energy Exhaustion via OMA1‐OPA1‐S in Acute Exacerbation of COPD	23
In Vitro and In Vivo Effects of Melatonin‐Containing Combinations in Human Pancreatic Ductal Adenocarcinoma	23
EXPRESSION OF CONCERN: Mitochondrial Function Is Controlled by Melatonin and Its Metabolites In Vitro in Human Melanoma Cells	22
Melatonin Ameliorates Circadian Disruption‐Associated Dry Eye via Modulation of BMAL1‐REV‐ERBα‐IL‐17 Axis and Ocular Surface Microbiota Homeostasis	22
Melatonin and verteporfin synergistically suppress the growth and stemness of head and neck squamous cell carcinoma through the regulation of mitochondrial dynamics	22
Multi‐Omics Analysis Reveals That AhNHL Contributes to Melatonin‐Mediated Cadmium Tolerance in Peanut Plants	21
Effect of melatonin on ATG2B‐mediated autophagy regulation in sheep granulosa cells with different Fec^B genotypes	21
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Single‐cell transcriptomic analysis reveals circadian rhythm disruption associated with poor prognosis and drug‐resistance in lung adenocarcinoma	20
Orphan GPR50 Restrains Neurite Outgrowth and Cell Migration by Activating the G_12/13 Protein‐RhoA Pathway in Neural Progenitor Cells and Tanycytes	20
Relating Photoperiod and Outdoor Temperature With Sleep Architecture in Patients With Neuropsychiatric Sleep Disorders	19
Protective Effects of Melatonin on Kidney Function Against Contrast Media‐Induced Kidney Damage in Patients With Chronic Kidney Disease: A Prospective, Randomized, Double‐Blinded, Placebo‐Controlled T	19
NPAS2 Deficiency Leads to Antidepressant‐Like Behaviors in Mice by Modulating Astrocyte‐Mediated Neuroinflammation	19
Mouse Models in Circadian Rhythm and Melatonin Research	19
Melatonin Alleviates Osteoarthritis by Regulating NADPH Oxidase 4–Induced Ferroptosis and Mitigating Mitochondrial Dysfunction	19
Melatonin Affects Peucedanum praeruptorum Vegetative Growth and Coumarin Synthesis by Modulating the Antioxidant System, Photosynthesis, and Endogenous Hormones	18
Melatonin Membrane Receptors in the Vascular System: Function, Modulation and Clinical Relevance	18
Melatonin as a key regulator in seed germination under abiotic stress	17
Cyclic uniaxial mechanical load enhances chondrogenesis through entraining the molecular circadian clock	17
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Melatonin MT1 receptors regulate the Sirt1/Nrf2/Ho‐1/Gpx4 pathway to prevent α‐synuclein‐induced ferroptosis in Parkinson's disease	16
Melatonin inhibits endometriosis development by disrupting mitochondrial function and regulating tiRNAs	16
Melatonin protects against developmental PBDE‐47 neurotoxicity by targeting the AMPK/mitophagy axis	15
Correction to “Melatonin/PGC1A/UCP1 promotes tumor slimming and represses tumor progression by initiating autophagy and lipid browning”	15
IAT4, a New Indolamine N‐Acetyltransferase in Saccharomyces cerevisiae Involved in Melatonin Biosynthesis	15
Melatonin sensitizes leukemia cells to the MCL1 inhibitors S63845 and A‐1210477 through multiple pathways	15
Melatonin and Exercise Restore Myogenesis and Mitochondrial Dynamics Deficits Associated With Sarcopenia in iMS‐Bmal1^−/− Mice	15
The Mechanism by Which Melatonin Improves the Dysregulation of Glucose and Lipid Metabolism in Castrated Female Mice	15
Melatonin, an Antitumor Necrosis Factor Therapy	15
Thirty‐seven years of MT1 and MT2 melatonin receptor localization in the brain: Past and future challenges	14
Melatonin Inhibits Endometriosis Growth via Specific Binding and Inhibition of EGFR Phosphorylation	14
Melatonin Supplementation Alleviates Bone Mineral Density Decline and Circulating Oxidative Stress in Iron‐Overloaded Thalassemia Patients	14
High sensitivity of melatonin suppression response to evening light in preschool‐aged children	14
Hypnotic effects of melatonin depend on the environmental lighting conditions in the rat	13
Melatonin Regulates Neuronal Synaptic Plasticity in the Supramammillary Nucleus and Attenuates Methamphetamine‐Induced Conditioned Place Preference and Sensitization in Mice	13

RETRACTION: Melatonin Inhibits Autophagy and Endoplasmic Reticulum Stress in Mice With Carbon Tetrachloride‐Induced Fibrosis	13
Weekly and seasonal variation in the circadian melatonin rhythm in humans: A response	13
Melatonin Regulates Rheumatoid Synovial Fibroblasts‐Related Inflammation: Implications for Pathological Skeletal Muscle Treatment	13
Zebrafish Dark‐Dependent Behavior Requires Phototransduction by the Pineal Gland	13
Melatonin reduces brain injury following inflammation‐amplified hypoxia–ischemia in a translational newborn piglet study of neonatal encephalopathy	12
Greater sensitivity of the circadian system of women to bright light, but not dim‐to‐moderate light	12
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Safety of higher doses of melatonin in adults: A systematic review and meta‐analysis	12
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Melatonin receptor structure and signaling	11
KARS Mutations Impair Brain Myelination by Inducing Oligodendrocyte Deficiency: One Potential Mechanism and Improvement by Melatonin	11
Direct Peritoneal Resuscitation and Melatonin in the Treatment of Abdominal Sepsis‐Induced Lung Injury via Macrophage Metabolic Reprogramming	11
Melatonin, Melatonin Receptors and Sleep: Moving Beyond Traditional Views	11
Cross‐species single‐cell landscape of vertebrate pineal gland	11
Melatonin rescues the mitochondrial function of bone marrow‐derived mesenchymal stem cells and improves the repair of osteoporotic bone defect in ovariectomized rats	11
Criticism on the Incorrect Use of Oxygen–Ozone Therapy in Medicine	11
Standardized and Calibrated Light Stimuli via Head‐Mounted Displays for Investigating the Nonvisual Effects of Light	11