OOIR: Observatory of International Research

Papers

(The H4-Index of Biomedicine & Pharmacotherapy is 92. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-07-01 to 2025-07-01.)

Article	Citations
The anti-fibrotic efficacy of adelmidrol depends on hepatic PPARγ levels	565
Editorial Board	315
Editorial Board	292
A new IRES-mediated truncated Cx32 isoform inhibits global mRNA translation to suppress glioblastoma	282
Disulfiram and metformin combination anticancer effect reversible partly by antioxidant nitroglycerin and completely by NF-κB activator mebendazole in hamster fibrosarcoma	252
Editorial Board	236
Editorial Board	236
Between therapy effect and false-positive result in animal experimentation	230
Corrigendum to “CRKL knockdown promotes in vitro proliferation, migration and invasion, in vivo tumor malignancy and lymph node metastasis of murine hepatocarcinoma Hca-P cells” [Biomed. Pharmacother.	229
Corrigendum to: ’Protective effect of vaginal resveratrol administration on joint tissues in ovariectomized rats: Targeting mTOR and сaspase 3’ [Biomed. Pharmacother. (2023) 115176/165]	228
Corrigendum to “Secretory products of DPSC mitigate inflammatory effects in microglial cells by targeting MAPK pathway” Biomed. Pharmacother. 170(2024) 115971	224
A phytotherapic blend immunity-6™ inhibits myeloid leukemic cells 2 activation involving purinergic signaling	221
Emerging role of carbon monoxide in intestinal transplantation	216
ACT001 inhibits primary central nervous system lymphoma tumor growth by enhancing the anti-tumor effect of T cells	207
Editorial Board	203
Advances in the role and mechanism of miRNA in inflammatory pain	198
Drug repurposing for neurodegenerative diseases using Zebrafish behavioral profiles	197
Induction of JAK2/STAT3 pathway contributes to protective effects of different therapeutics against myocardial ischemia/reperfusion	186
Clofazimine: A journey of a drug	186
Impact of tumor suppressor genes inactivation on the multidrug resistance phenotype of hepatocellular carcinoma cells	185
The interaction between ETS transcription factor family members and microRNAs: A novel approach to cancer therapy	174
Molecular insight into arrhythmogenic cardiomyopathy caused by DSG2 mutations	173
Erythropoietin-mediated IL-17 F attenuates sepsis-induced gut microbiota dysbiosis and barrier dysfunction	171
Imbalance of gut microbiota is involved in the development of chronic obstructive pulmonary disease: A review	171
Hippocampus kuda protein hydrolysate improves male reproductive dysfunction in diabetic rats	170

Dihydromyricetin treats pulmonary hypertension by modulating CKLF1/CCR5 axis-induced pulmonary vascular cell pyroptosis	168
Mannosylated polylactic-co-glycolic acid (MN-PLGA) nanoparticles induce potent anti-tumor immunity in murine model of breast cancer	167
The role of the serotonergic system in atropine’s anti-myopic effects	162
Overcoming drug delivery barriers and challenges in topical therapy of atopic dermatitis: A nanotechnological perspective	159
CircRNA: An emerging star in the progression of glioma	155
Development of vericiguat: The first soluble guanylate cyclase (sGC) stimulator launched for heart failure with reduced ejection fraction (HFrEF)	154
Medicinal and mechanistic overview of artemisinin in the treatment of human diseases	153
Bacterial outer membrane vesicles in cancer: Biogenesis, pathogenesis, and clinical application	148
Targeting mitochondria as a potential therapeutic strategy against chemoresistance in cancer	143
Cuproptosis in cancers: Function and implications from bench to bedside	141
Sildenafil delays bone remodeling of fractured femora in aged mice by reducing the number and activity of osteoclasts within the callus tissue	139
The phenolic compounds tyrosol and hydroxytyrosol counteract liver fibrogenesis via the transcriptional modulation of NADPH oxidases and oxidative stress-related miRNAs	137
Modulating autophagy to boost the antitumor efficacy of TROP2-directed antibody-drug conjugate in pancreatic cancer	136
Beneficial effects of carvedilol modulating potassium channels on the control of glucose	132
The use of a selective, nontoxic dual-acting peptide for breast cancer patients with brain metastasis	132
Tea (Camellia sinensis) ameliorates DSS-induced colitis and liver injury by inhibiting TLR4/NF-κB/NLRP3 inflammasome in mice	131
Elucidating cuproptosis in metabolic dysfunction-associated steatotic liver disease	130
Monitoring of lamotrigine concentrations in mothers, colostrum, and breastfed newborns during the early postpartum period	130
Celastrol exerts antiarrhythmic effects in chronic heart failure via NLRP3/Caspase-1/IL-1β signaling pathway	129
Cervical carcinoma high expressed 1 (CCHE1): An oncogenic lncRNA in diverse neoplasms	128
Role of long noncoding RNAs in pathological cardiac remodeling after myocardial infarction: An emerging insight into molecular mechanisms and therapeutic potential	125
The prospect of combination therapies with the third-generation EGFR-TKIs to overcome the resistance in NSCLC	123
Empagliflozin adjunct with metformin for the inhibition of hepatocellular carcinoma progression: Emerging approach for new application	123
The melatonergic agonist agomelatine ameliorates high fat diet-induced obesity in mice through the modulation of the gut microbiome	121
Egg white protein hydrolysate ameliorated sepsis-induced inflammatory injuries in kidney and liver based on metabolomics analysis	121
Breaking the vicious cycle: Targeting the NLRP3 inflammasome for treating sepsis-associated encephalopathy	119
Si-Ni-San reverses dietary fat absorption defects in a murine model of depression	119
Analytical validation of a novel UHPLC-MS/MS method for 19 antibiotics quantification in plasma: Implementation in a LC-MS/MS Kit	117
Tomato (Solanum lycopersicum L.) seed: A review on bioactives and biomedical activities	117
Granulocyte colony-stimulating factor in reproductive-related disease: Function, regulation and therapeutic effect	116
Ethanolic extract of Pyrrosia lingua (Thunb.) Farw. ameliorates OVX-induced bone loss and RANKL-induced osteoclastogenesis	114
Retraction notice to “MiR-155–5p promotes oral cancer progression by targeting chromatin remodeling gene ARID2” [Biomed. Pharmacother. 122 (2020) 109696]	114
NADPH and NAC synergistically inhibits chronic ocular hypertension-induced neurodegeneration and neuroinflammation through regulating p38/MAPK pathway and peroxidation	114
Neural crest-derived cells possess differentiation potential to keratinocytes in the process of wound healing	113
Silencing tumor-intrinsic CD73 enhances the chemosensitivity of NSCLC and potentiates the anti-tumoral effects of cisplatin: An in vitro study	113
Rejuvenating hepatic tumor microenvironment immunity with a phosphatidylserine-targeting small molecule drug conjugate	111
Tracking Chlamydia – Host interactions and antichlamydial activity in Caenorhabditis elegans	111
Efficient generation of a CYP3A4-T2A-luciferase knock-in HepaRG subclone and its optimized differentiation	109
A combined transcriptomics and proteomics approach to reveal the mechanism of AEE relieving hyperlipidemia in ApoE-/- mice	109
Recent advances on European research in the field of "Biomedicine & Pharmacotherapy"	108
Expression of concern: MicroRNA-370 protects against myocardial ischemia/reperfusion injury in mice following sevoflurane anesthetic preconditioning through PLIN5- dependent PPAR signaling pathway [Bi	107
Expression of concern: miR-539 enhances chemosensitivity to cisplatin in non-small cell lung cancer by targeting DCLK1 [Biomedicine & Pharmacotherapy 106 (2018) 1072–1081]	106
Expression of concern: MicroRNA-497 promotes proliferation and inhibits apoptosis of cardiomyocytes through the downregulation of Mfn2 in a mouse model of myocardial ischemia-reperfusion injury [Biome	106
Retraction notice to “Piperine alleviates lipopolysaccharide-induced inflammatory injury by down-regulating microRNA-127 in murine chondrogenic ATDC5 cells” [Biomed. Pharmacother. 103 (2018) 947–954]	104
Retraction notice to “Alkannin protects human renal proximal tubular epithelial cells from LPS-induced inflammatory injury by regulation of microRNA-210” [Biomed. Pharmacother. 108 (2018) 1679–1685]	104
Longitudinal stability of molecular alterations and drug response profiles in tumor spheroid cell lines enables reproducible analyses	104
Editorial Board	103
Endoplasmic reticulum stress in intestinal microecology: A controller of antineoplastic drug-related cardiovascular toxicity	102
Retraction notice to "Helenalin from Centipeda minima ameliorates acute hepatic injury by protecting mitochondria function, activating Nrf2 pathway and inhibiting NF-κB activation" [Biomed. Pharmacoth	100
Retraction notice to “Overexpression of macrophage stimulating 1 enhances the anti-tumor effects of IL-24 in esophageal cancer via inhibiting ERK-Mfn2 signaling-dependent mitophagy” [Biomed. Pharmacot	100

Retraction notice to “Effects of Artesunate on chondrocyte proliferation, apoptosis and autophagy through the PI3K/AKT/mTOR signaling pathway in rat models with rheumatoid arthritis” [Biomed. Pharmaco	100
CXCL12 inhibits hair growth through CXCR4	99
Kefir peptides mitigate L-NAME-induced preeclampsia in rats through modulating hypertension and endothelial dysfunction	99
Streptococcus thermophilus CNCM I-5570 lysate counteracts the aging process in human dermal fibroblast cells by neutralizing harmful free radicals and impacting antioxidant and anti-inflammatory pathw	99
Seroprevalence of SARS-CoV-2-specific antibodies and vaccination-related adverse events in systemic lupus erythematosus and rheumatoid arthritis	99
Colchicine: Emerging therapeutic effects on atrial fibrillation by alleviating myocardial fibrosis in a rat model	98
Palbociclib promotes the antitumor activity of Venetoclax plus Azacitidine against acute myeloid leukemia	98
Potential roles of exosomes in the initiation and metastatic progression of lung cancer	97
Targeting hypoxia-related metabolism molecules: How to improve tumour immune and clinical treatment?	96
The AhR/P38 MAPK pathway mediates kynurenine-induced cardiomyocyte damage: The dual role of resveratrol in apoptosis and autophagy	95
Multi-organ model assessment of neurotoxicity following exposure of liver spheroids to drugs	95
Glioblastoma targeting by water-soluble hypericin derivate HHL-PVP and photodynamic tumour killing	94
Synergic effect of bone marrow derived mesenchymal stem cells and differentiated keratinocytes-like cells with a novel cellulose and collagen nanoscaffold on wound healing in rats	94
Scutellarin enhances anti-tumor immune responses by reducing TNFR2-expressing CD4+Foxp3+ regulatory T cells	93
Squalene nanoemulsion reinforces mucosal and immunological fingerprints following intravaginal delivery	93
Discovery of a novel NUAK1 inhibitor against pancreatic cancer	93
Advance on combination therapy strategies based on biomedical nanotechnology induced ferroptosis for cancer therapeutics	93
Sesquiterpene lactones as potential therapeutic agents against Naegleria fowleri	92
Effective-component compatibility of Bufei Yishen formula alleviates chronic obstructive pulmonary disease inflammation by regulating GSK3β-mediated NLRP3 inflammasome activation	92
Discovery of a synthetic taiwaniaquinoid with potent in vitro and in vivo antitumor activity against breast cancer cells	92