OOIR: Observatory of International Research

Papers

(The H4-Index of Biomedicine & Pharmacotherapy is 83. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
The emerging role of ferroptosis in inflammation	363
Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management	318
The role of IL-1β and TNF-α in intervertebral disc degeneration	286
Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols	277
Gallic acid: Pharmacological activities and molecular mechanisms involved in inflammation-related diseases	272
Type II diabetes mellitus: a review on recent drug based therapeutics	261
Adipose tissue and insulin resistance in obese	260
EMT, cancer stem cells and autophagy; The three main axes of metastasis	241
Isorhamnetin: A review of pharmacological effects	221
5-Fluorouracil (5-FU) resistance and the new strategy to enhance the sensitivity against cancer: Implication of DNA repair inhibition	216
New understanding of the damage of SARS-CoV-2 infection outside the respiratory system	213
An update on β-sitosterol: A potential herbal nutraceutical for diabetic management	200
Lipase Inhibitors for Obesity: A Review	183
ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID-19	176
WNT/β-catenin signaling in the development of liver cancers	175
Role of lncRNA LUCAT1 in cancer	167
Antiviral activities of flavonoids	166
The role of iron in the pathogenesis of COVID-19 and possible treatment with lactoferrin and other iron chelators	166
Anticancer activities of TCM and their active components against tumor metastasis	165
Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease	164
Myricetin: A review of the most recent research	164
Antiproliferative and palliative activity of flavonoids in colorectal cancer	162
Current potential therapeutic strategies targeting the TGF-β/Smad signaling pathway to attenuate keloid and hypertrophic scar formation	160
Natural carbon-based quantum dots and their applications in drug delivery: A review	158
Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms	157

The role of curcumin in aging and senescence: Molecular mechanisms	154
Resveratrol (RV): A pharmacological review and call for further research	152
Oxindole and its derivatives: A review on recent progress in biological activities	139
Role of microbiota-derived short-chain fatty acids in cancer development and prevention	139
Gastroprotective effect of gallic acid against ethanol-induced gastric ulcer in rats: Involvement of the Nrf2/HO-1 signaling and anti-apoptosis role	135
Exosomes as drug carriers for cancer therapy and challenges regarding exosome uptake	132
The main bioactive compounds of Scutellaria baicalensis Georgi. for alleviation of inflammatory cytokines: A comprehensive review	131
Composite probiotics alleviate type 2 diabetes by regulating intestinal microbiota and inducing GLP-1 secretion in db/db mice	130
Role of the NLRP3 inflammasome in autoimmune diseases	129
Immune boosting functional foods and their mechanisms: A critical evaluation of probiotics and prebiotics	124
Lipocalin-2: Structure, function, distribution and role in metabolic disorders	124
MicroRNA: A signature for cancer progression	122
Mechanistic insights and perspectives involved in neuroprotective action of quercetin	120
The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway	119
A review on the potential of Resveratrol in prevention and therapy of diabetes and diabetic complications	118
Immune defence to invasive fungal infections: A comprehensive review	118
Monoclonal antibody as a potential anti-COVID-19	117
Role of microbiota-derived short-chain fatty acids in nervous system disorders	114
Natural history of COVID-19 and current knowledge on treatment therapeutic options	111
Probiotics for cancer alternative prevention and treatment	110
Berberine represses human gastric cancer cell growth in vitro and in vivo by inducing cytostatic autophagy via inhibition of MAPK/mTOR/p70S6K and Akt signaling pathways	109
New insight towards development of paclitaxel and docetaxel resistance in cancer cells: EMT as a novel molecular mechanism and therapeutic possibilities	108
Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents	105
AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: A pre-clinical and clinical investigation	105
Flavonoids against the SARS-CoV-2 induced inflammatory storm	102
Innate and adaptive immune responses against coronavirus	102
Pleotropic Effects of Polyphenols in Cardiovascular System	101
Mechanisms of BCG in the treatment of bladder cancer-current understanding and the prospect	101
Novel advances in inhibiting advanced glycation end product formation using natural compounds	100
Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence	100
Insights into antiviral mechanisms of remdesivir, lopinavir/ritonavir and chloroquine/hydroxychloroquine affecting the new SARS-CoV-2	98
NF-κB inhibitors in treatment and prevention of lung cancer	98
CAR-macrophage: A new immunotherapy candidate against solid tumors	97
Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer’s disease	96
Gestational diabetes mellitus - A metabolic and reproductive disorder	96
Potential inhibitory effect of lycopene on prostate cancer	95
A review on the pharmacokinetics of paeoniflorin and its anti-inflammatory and immunomodulatory effects	95
Progress of exosomes in the diagnosis and treatment of lung cancer	94
Standardized extract of ginger ameliorates liver cancer by reducing proliferation and inducing apoptosis through inhibition oxidative stress/ inflammation pathway	92
Mechanisms of blue light-induced eye hazard and protective measures: a review	92
Pharmacological properties and underlying mechanisms of curcumin and prospects in medicinal potential	91
Protection against COVID-19 injury by qingfei paidu decoction via anti-viral, anti-inflammatory activity and metabolic programming	91
Traditional Chinese medicine and lung cancer——From theory to practice	91
A comprehensive review on Pueraria: Insights on its chemistry and medicinal value	90
The links between gut microbiota and obesity and obesity related diseases	89
STING is an essential regulator of heart inflammation and fibrosis in mice with pathological cardiac hypertrophy via endoplasmic reticulum (ER) stress	88
Ginsenosides for the treatment of metabolic syndrome and cardiovascular diseases: Pharmacology and mechanisms	88
Polymer-hybrid nanoparticles: Current advances in biomedical applications	87
Scoparone improves hepatic inflammation and autophagy in mice with nonalcoholic steatohepatitis by regulating the ROS/P38/Nrf2 axis and PI3K/AKT/mTOR pathway in macrophages	87
Biomedical applications of metallic nanoparticles in cancer: Current status and future perspectives	86

EF24 induces ferroptosis in osteosarcoma cells through HMOX1	86
Emerging role of NRF2 in ROS-mediated tumor chemoresistance	86
Intestinal barrier damage, systemic inflammatory response syndrome, and acute lung injury: A troublesome trio for acute pancreatitis	86
Pharmacological basis and new insights of taxifolin: A comprehensive review	85
Modified citrus pectin ameliorates myocardial fibrosis and inflammation via suppressing galectin-3 and TLR4/MyD88/NF-κB signaling pathway	85
Polysaccharides from Polygonatum kingianum improve glucose and lipid metabolism in rats fed a high fat diet	85
Clinical retrospective study on the efficacy of Qingfei Paidu decoction combined with Western medicine for COVID-19 treatment	85
Gene therapy clinical trials, where do we go? An overview	84
The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling	83
Folic acid (FA)-conjugated mesoporous silica nanoparticles combined with MRP-1 siRNA improves the suppressive effects of myricetin on non-small cell lung cancer (NSCLC)	83
Silica nanoparticles: Biomedical applications and toxicity	83