OOIR: Observatory of International Research

Papers

(The H4-Index of Biomedicine & Pharmacotherapy is 87. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Antidiabetic and antioxidant potential of total extract and supernatant fraction of the roots of Anogeissus leiocarpus in HFD-fed and Streptozocin -induced diabetic rats	510
Hippocampus kuda protein hydrolysate improves male reproductive dysfunction in diabetic rats	490
Mitochondrial metabolism regulated macrophage phenotype in myocardial infarction	344
Corrigendum to “Riluzole ameliorates learning and memory deficits in Aβ25–35-induced rat model of Alzheimer’s disease and is independent of cholinoceptor activation” [Biomedicine & Pharmacotherapy	266
Dysbiosis and diabetic foot ulcers: A metabolic perspective of Staphylococcus aureus infection	254
Isoliquiritigenin alleviates SLC7A11-mediated efferocytosis inhibition to promote wounds healing in diabetes	253
Kefir peptides mitigate L-NAME-induced preeclampsia in rats through modulating hypertension and endothelial dysfunction	226
Pharmacological differences in postoperative cutaneous sensitivity, pain at rest, and movement-induced pain in laparotomized mice	217
Potential mechanisms of Treponema pallidum breaching the blood-brain barrier	209
Intradermal administration of novel particulate Chlamydia trachomatis vaccine candidates drives protective immune responses	206
Editorial Board	206
Developing a novel P-glycoprotein inhibitor and pairing it with oral paclitaxel liposomes for enhanced cancer therapy	204
Oridonin alleviates cigarette smoke-induced nasal polyp formation by promoting autophagy	202
Novel [18F]FPG-interleukin-2 conjugate for monitoring immune checkpoint therapy with positron emission tomography	201
PAD inhibition downregulates the cellular fibrotic behavior of senescent myofibroblasts derived from dilated cardiomyopathy	201
Triptolide-induced acute liver injury and its mechanism with estradiol in regulating macrophage-mediated inflammation and hepatocyte function	200
Retraction notice to "Physcion Induces apoptosis through triggering endoplasmic reticulum stress in hepatocellular carcinoma"[Biomed. Pharmacother. 99(2018) 894–903]	198
Retraction notice to "Overexpression of FADD and Caspase-8 inhibits proliferation and promotes apoptosis of human glioblastoma cells" [Biomed. Pharmacother. 93 (2017) 1–7]	189
Retraction notice to "Possible mechanisms involved in the protective effects of chrysin against lead-induced cognitive decline: An in vivo study in a rat model" [Biomed. Pharmacother. 157 (2022) 11401	173
Retraction notice to “Overexpression of macrophage stimulating 1 enhances the anti-tumor effects of IL-24 in esophageal cancer via inhibiting ERK-Mfn2 signaling-dependent mitophagy” [Biomed. Pharmacot	173
Retraction notice to "Ameliorative potential of sitagliptin and/or resveratrol on experimentally-induced clear cell renal cell carcinoma" [Biomed. Pharmacother. 97 (2017) 667–674	161
Expression of concern: Matrine inhibits hypoxia/reoxygenation-induced apoptosis of cardiac microvascular endothelial cells in rats via the JAK2/STAT3 signaling pathway [Biomedicine & Pharmacothera	159
Retraction notice to "Helenalin from Centipeda minima ameliorates acute hepatic injury by protecting mitochondria function, activating Nrf2 pathway and inhibiting NF-κB activation" [Biomed. Pharmacoth	158
Retraction notice to “Piperine alleviates lipopolysaccharide-induced inflammatory injury by down-regulating microRNA-127 in murine chondrogenic ATDC5 cells” [Biomed. Pharmacother. 103 (2018) 947–954]	157
Retraction notice to “Alkannin protects human renal proximal tubular epithelial cells from LPS-induced inflammatory injury by regulation of microRNA-210” [Biomed. Pharmacother. 108 (2018) 1679–1685]	153

Retraction notice to "Emodin attenuates apoptosis and inflammation induced by LPS through up-regulating lncRNA TUG1 in murine chondrogenic ATDC5 cells" [Biomed. Pharmacother. 103 (2018) 897 – 902]	152
Retraction notice to “Long non-coding RNA TTN-AS1 promotes tumorigenesis of ovarian cancer through modulating the miR-139–5p/ROCK2 axis” [Biomed. Pharmacother. 125 (2020) 109882]	151
Expression of concern: miR-539 enhances chemosensitivity to cisplatin in non-small cell lung cancer by targeting DCLK1 [Biomedicine & Pharmacotherapy 106 (2018) 1072–1081]	150
Retraction notice to "Tripterine alleviates LPS-induced inflammatory injury by up-regulation of miR-146a in HaCaT cells" [Biomed. Pharmacother. 105 (2018) 798–804]	149
Retraction notice to “Effects of Artesunate on chondrocyte proliferation, apoptosis and autophagy through the PI3K/AKT/mTOR signaling pathway in rat models with rheumatoid arthritis” [Biomed. Pharmaco	146
Expression of concern: Repression of long non-coding RNA MEG3 restores nerve growth and alleviates neurological impairment after cerebral ischemia-reperfusion injury in a rat model. [Biomedicine &	143
Expression of concern: MicroRNA-497 promotes proliferation and inhibits apoptosis of cardiomyocytes through the downregulation of Mfn2 in a mouse model of myocardial ischemia-reperfusion injury [Biome	138
Retraction notice to “Long non-coding RNA LINC00525 promotes the non-small cell lung cancer progression by targeting miR-338-3p/IRS2 axis” [Biomed. Pharmacother. 124 (2020) 109858]	134
Expression of concern: Long noncoding RNA PVT1 enhances the viability and invasion of papillary thyroid carcinoma cells by functioning as ceRNA of microRNA-30a through mediating expression of insulin	133
Retraction notice to “Matrine inhibits hypoxia/reoxygenation-induced apoptosis of cardiac microvascular endothelial cells in rats via the JAK2/STAT3 signaling pathway” [Biomed. Pharmacother. 106 (2018	133
Expression of concern: MicroRNA-370 protects against myocardial ischemia/reperfusion injury in mice following sevoflurane anesthetic preconditioning through PLIN5- dependent PPAR signaling pathway [Bi	124
A novel potent class I HDAC inhibitor reverses the STAT4/p66Shc apoptotic defect in B cells from chronic lymphocytic leukemia patients	122
Prescriptive behavior of non-vitamin K oral anticoagulants in patients affected by atrial fibrillation in general practice	121
Radiopaque hydrogel-in-liposomes towards theranostic applications for malignant tumors	119
Effects of sacubitril/valsartan on cardiac remodeling in heart failure with reduced ejection fraction: An integrated study of molecular biomarkers and imaging techniques	119
8-Oxypalmatine, a novel oxidative metabolite of palmatine, exhibits superior anti-colitis effect via regulating Nrf2 and NLRP3 inflammasome	119
MITOCDNB DECREASES PLATELET ACTIVATION THROUGH ITS SELECTIVE ACTION ON MITOCHONDRIAL THIOREDOXIN REDUCTASE	117
Oxaliplatin reversibly and differentially affects electrogenic activity of small IB4(+) of male and female rat sensory neurons	117
Therapeutic effects of CGS21680, a selective A2A receptor agonist, via BDNF-related pathways in R106W mutation Rett syndrome model	117
Illudin S inhibits p53-Mdm2 interaction for anticancer efficacy in colorectal cancer	116
HEBE: A novel chimeric chronokine for ameliorating memory deficits in Alzheimer’s disease	115
Towards dual function of autophagy in breast cancer: A potent regulator of tumor progression and therapy response	114
Patient-derived tumor models in cancer research: Evaluation of the oncostatic effects of melatonin	113
Gentianella acuta improves TAC-induced cardiac remodelling by regulating the Notch and PI3K/Akt/FOXO1/3 pathways	112
Advances in lacrimal gland organoid development: Techniques and therapeutic applications	111
Status of research on natural protein tyrosine phosphatase 1B inhibitors as potential antidiabetic agents: Update	111
Melatonin regulates microglial M1/M2 polarization via AMPKα2-mediated mitophagy in attenuating sepsis-associated encephalopathy	111
Tacrolimus regulates extracellular vesicle secretion from T cells via autophagy-lysosomal pathway	109
Helminth-derived molecules improve 5-fluorouracil treatment on experimental colon tumorigenesis	109
YL-109 attenuates sepsis-associated multiple organ injury through inhibiting the ERK/AP-1 axis and pyroptosis by upregulating CHIP	107
Hypotensive drugs mitigate the high-sodium diet-induced pro-inflammatory activation of mouse macrophages in vivo	106
Cardiovascular outcomes and molecular targets for the cardiac effects of Sodium-Glucose Cotransporter 2 Inhibitors: A systematic review	105
Mitochondrial dynamics dysfunction: Unraveling the hidden link to depression	105
Combined in vivo effect of N-acylethanolamine-hydrolyzing acid amidase and glycogen synthase kinase-3β inhibition to treat multiple sclerosis	104
Nature-inspired substituted 3-(imidazol-2-yl) morpholines targeting human topoisomerase IIα: Dynophore-derived discovery	104
Formyl peptide enhances cancer immunotherapy by activating antitumoral neutrophils, and T cells	104
CaMKII activity and metabolic imbalance-related neurological diseases: Focus on vascular dysfunction, synaptic plasticity, amyloid beta accumulation, and lipid metabolism	102
NADPH and NAC synergistically inhibits chronic ocular hypertension-induced neurodegeneration and neuroinflammation through regulating p38/MAPK pathway and peroxidation	102
A multifunctional antibody fusion protein 57103 targeting CD24, IL-4R, and αvβ3 for treating cancer and regulating the tumor microenvironment	101
Low-dose cadmium induces lymphangiogenesis through activation of the STAT3 signaling pathway	100
Novel insight into the role of A-kinase anchoring proteins (AKAPs) in ischemic stroke and therapeutic potentials	100
Ketamine administration causes cognitive impairment by destroying the circulation function of the glymphatic system	100
Development of alginate and alginate sulfate/polycaprolactone nanoparticles for growth factor delivery in wound healing therapy	99
Targeting KEAP1-mediated IKKβ degradation strategy for colitis-associated colorectal carcinogenesis: The potential of xanthohumol	99
Corrigendum to “Advances in lacrimal gland organoid development: Techniques and therapeutic applications” [Biomed. Pharmacother. 183 (2025) 117870]	98
Retraction notice to “Cilostazol protects mice against myocardium ischemic/reperfusion injury by activating a PPAR?/JAK2/STAT3 pathway” [Biomed. Pharmacother. 94 (2017) 995–1001]	98
Evaluation of the effect of Hashimoto's Thyroiditis on fatty acids involved in inflammation in the thyroid tissue	97
Retraction notice to “MiR-155–5p promotes oral cancer progression by targeting chromatin remodeling gene ARID2” [Biomed. Pharmacother. 122 (2020) 109696]	97
Ibogalogs decrease neuropathic pain in mice through a mechanism involving crosstalk between 5-HT2A and mGlu2 receptors	96
Response of Alzheimer's disease-like triple transgenic 3x-Tg mice to experimental migraine evoked by nitroglycerin	94

Thiopurine S-methyltransferase – An important intersection of drug-drug interactions in thiopurine treatment	94
1-benzyl-6-nitro-4-phenyl-4-(methoxycarbonyl)-2(1H)-pyridinone, a novel pirfenidone derivative, alleviate hepatic fibrosis through T cells	94
Bryophyllum pinnatum modulation of signaling pathways relevant for preterm labor in human myometrial cells	93
Unveiling lactylation modification: A new hope for cancer treatment	91
Contribution of human organic anion transporter 3-mediated transport of a major linezolid metabolite, PNU-142586, in linezolid-induced thrombocytopenia	91
Right ventricular dysfunction following surgical repair of tetralogy of Fallot: Molecular pathways and therapeutic prospects	91
RETRACTED: mPEG-b-P(Glu-co-Phe) nanoparticles increase gastric retention time and gastric ulcer treatment efficacy of 20(S)-ginsenoside Rg3	90
Current status of superoxide dismutase 2 on oral disease progression by supervision of ROS	89
Phytochemicals targeting lncRNAs: A novel direction for neuroprotection in neurological disorders	88
Cisplatin-loaded gold nanoshells mediate chemo-photothermal therapy against primary and distal lung cancers growth	88
3,5-Dicaffeoylquinic acid attenuates microglial activation-mediated inflammatory pain by enhancing autophagy through the suppression of MCP3/JAK2/STAT3 signaling	87
Acetyl-L-carnitine and/or liposomal co-enzyme Q10 prevent propionic acid-induced neurotoxicity by modulating oxidative tissue injury, inflammation, and ALDH1A1-RA-RARα signaling in rats	87