Biomedicine & Pharmacotherapy

Article	Citations
The emerging role of ferroptosis in inflammation	363
Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management	318
The role of IL-1β and TNF-α in intervertebral disc degeneration	286
Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols	277
Gallic acid: Pharmacological activities and molecular mechanisms involved in inflammation-related diseases	272
Type II diabetes mellitus: a review on recent drug based therapeutics	261
Adipose tissue and insulin resistance in obese	260
EMT, cancer stem cells and autophagy; The three main axes of metastasis	241
Isorhamnetin: A review of pharmacological effects	221
5-Fluorouracil (5-FU) resistance and the new strategy to enhance the sensitivity against cancer: Implication of DNA repair inhibition	216
New understanding of the damage of SARS-CoV-2 infection outside the respiratory system	213
An update on β-sitosterol: A potential herbal nutraceutical for diabetic management	200
Lipase Inhibitors for Obesity: A Review	183
ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID-19	176
WNT/β-catenin signaling in the development of liver cancers	175
Role of lncRNA LUCAT1 in cancer	167
Antiviral activities of flavonoids	166
The role of iron in the pathogenesis of COVID-19 and possible treatment with lactoferrin and other iron chelators	166
Anticancer activities of TCM and their active components against tumor metastasis	165
Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease	164
Myricetin: A review of the most recent research	164
Antiproliferative and palliative activity of flavonoids in colorectal cancer	162
Current potential therapeutic strategies targeting the TGF-β/Smad signaling pathway to attenuate keloid and hypertrophic scar formation	160
Natural carbon-based quantum dots and their applications in drug delivery: A review	158
Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms	157

The role of curcumin in aging and senescence: Molecular mechanisms	154
Resveratrol (RV): A pharmacological review and call for further research	152
Oxindole and its derivatives: A review on recent progress in biological activities	139
Role of microbiota-derived short-chain fatty acids in cancer development and prevention	139
Gastroprotective effect of gallic acid against ethanol-induced gastric ulcer in rats: Involvement of the Nrf2/HO-1 signaling and anti-apoptosis role	135
Exosomes as drug carriers for cancer therapy and challenges regarding exosome uptake	132
The main bioactive compounds of Scutellaria baicalensis Georgi. for alleviation of inflammatory cytokines: A comprehensive review	131
Composite probiotics alleviate type 2 diabetes by regulating intestinal microbiota and inducing GLP-1 secretion in db/db mice	130
Role of the NLRP3 inflammasome in autoimmune diseases	129
Lipocalin-2: Structure, function, distribution and role in metabolic disorders	124
Immune boosting functional foods and their mechanisms: A critical evaluation of probiotics and prebiotics	124
MicroRNA: A signature for cancer progression	122
Mechanistic insights and perspectives involved in neuroprotective action of quercetin	120
The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway	119
A review on the potential of Resveratrol in prevention and therapy of diabetes and diabetic complications	118
Immune defence to invasive fungal infections: A comprehensive review	118
Monoclonal antibody as a potential anti-COVID-19	117
Role of microbiota-derived short-chain fatty acids in nervous system disorders	114
Natural history of COVID-19 and current knowledge on treatment therapeutic options	111
Probiotics for cancer alternative prevention and treatment	110
Berberine represses human gastric cancer cell growth in vitro and in vivo by inducing cytostatic autophagy via inhibition of MAPK/mTOR/p70S6K and Akt signaling pathways	109
New insight towards development of paclitaxel and docetaxel resistance in cancer cells: EMT as a novel molecular mechanism and therapeutic possibilities	108
Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents	105
AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: A pre-clinical and clinical investigation	105
Flavonoids against the SARS-CoV-2 induced inflammatory storm	102
Innate and adaptive immune responses against coronavirus	102
Pleotropic Effects of Polyphenols in Cardiovascular System	101
Mechanisms of BCG in the treatment of bladder cancer-current understanding and the prospect	101
Novel advances in inhibiting advanced glycation end product formation using natural compounds	100
Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence	100
NF-κB inhibitors in treatment and prevention of lung cancer	98
Insights into antiviral mechanisms of remdesivir, lopinavir/ritonavir and chloroquine/hydroxychloroquine affecting the new SARS-CoV-2	98
CAR-macrophage: A new immunotherapy candidate against solid tumors	97
Gestational diabetes mellitus - A metabolic and reproductive disorder	96
Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer’s disease	96
A review on the pharmacokinetics of paeoniflorin and its anti-inflammatory and immunomodulatory effects	95
Potential inhibitory effect of lycopene on prostate cancer	95
Progress of exosomes in the diagnosis and treatment of lung cancer	94
Mechanisms of blue light-induced eye hazard and protective measures: a review	92
Standardized extract of ginger ameliorates liver cancer by reducing proliferation and inducing apoptosis through inhibition oxidative stress/ inflammation pathway	92
Traditional Chinese medicine and lung cancer——From theory to practice	91
Pharmacological properties and underlying mechanisms of curcumin and prospects in medicinal potential	91
Protection against COVID-19 injury by qingfei paidu decoction via anti-viral, anti-inflammatory activity and metabolic programming	91
A comprehensive review on Pueraria: Insights on its chemistry and medicinal value	90
The links between gut microbiota and obesity and obesity related diseases	89
Ginsenosides for the treatment of metabolic syndrome and cardiovascular diseases: Pharmacology and mechanisms	88
STING is an essential regulator of heart inflammation and fibrosis in mice with pathological cardiac hypertrophy via endoplasmic reticulum (ER) stress	88
Polymer-hybrid nanoparticles: Current advances in biomedical applications	87
Scoparone improves hepatic inflammation and autophagy in mice with nonalcoholic steatohepatitis by regulating the ROS/P38/Nrf2 axis and PI3K/AKT/mTOR pathway in macrophages	87
Biomedical applications of metallic nanoparticles in cancer: Current status and future perspectives	86

EF24 induces ferroptosis in osteosarcoma cells through HMOX1	86
Emerging role of NRF2 in ROS-mediated tumor chemoresistance	86
Intestinal barrier damage, systemic inflammatory response syndrome, and acute lung injury: A troublesome trio for acute pancreatitis	86
Pharmacological basis and new insights of taxifolin: A comprehensive review	85
Modified citrus pectin ameliorates myocardial fibrosis and inflammation via suppressing galectin-3 and TLR4/MyD88/NF-κB signaling pathway	85
Polysaccharides from Polygonatum kingianum improve glucose and lipid metabolism in rats fed a high fat diet	85
Clinical retrospective study on the efficacy of Qingfei Paidu decoction combined with Western medicine for COVID-19 treatment	85
Gene therapy clinical trials, where do we go? An overview	84
The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling	83
Folic acid (FA)-conjugated mesoporous silica nanoparticles combined with MRP-1 siRNA improves the suppressive effects of myricetin on non-small cell lung cancer (NSCLC)	83
Silica nanoparticles: Biomedical applications and toxicity	83
Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects	82
Onion (Allium cepa L.) peels: A review on bioactive compounds and biomedical activities	81
Sodium-glucose co-transporter-2 (SGLT-2) inhibition reduces glucose uptake to induce breast cancer cell growth arrest through AMPK/mTOR pathway	81
MicroRNAs in Alzheimer's disease: Potential diagnostic markers and therapeutic targets	81
Pharmacological insights and prediction of lead bioactive isolates of Dita bark through experimental and computer-aided mechanism	81
Tumor-infiltrating lymphocytes: Warriors fight against tumors powerfully	80
Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets	80
Therapeutic targets of neuroprotection and neurorestoration in ischemic stroke: Applications for natural compounds from medicinal herbs	79
Recent progress in TGF-β inhibitors for cancer therapy	79
Traditional Chinese medicine combined with pulmonary drug delivery system and idiopathic pulmonary fibrosis: Rationale and therapeutic potential	78
The role of miRNAs in colorectal cancer progression and chemoradiotherapy	78
Solasonine promotes ferroptosis of hepatoma carcinoma cells via glutathione peroxidase 4-induced destruction of the glutathione redox system	78
Safety profile of the antiviral drug remdesivir: An update	77
The role of Interleukin 6 inhibitors in therapy of severe COVID-19	77
Strategies and perspectives to develop SARS-CoV-2 detection methods and diagnostics	77
Polyphenols inhibiting MAPK signalling pathway mediated oxidative stress and inflammation in depression	76
Combined chemotherapy with cyclooxygenase-2 (COX-2) inhibitors in treating human cancers: Recent advancement	76
Efficacy of Brazilian green propolis (EPP-AF®) as an adjunct treatment for hospitalized COVID-19 patients: A randomized, controlled clinical trial	76
Impact of virus genetic variability and host immunity for the success of COVID-19 vaccines	76
Principles of RNA methylation and their implications for biology and medicine	75
Antitumor activity and mechanism of costunolide and dehydrocostus lactone: Two natural sesquiterpene lactones from the Asteraceae family	75
Dexmedetomidine attenuates myocardial ischemia/reperfusion-induced ferroptosis via AMPK/GSK-3β/Nrf2 axis	75
Prospective multifunctional roles and pharmacological potential of dietary flavonoid narirutin	75
Role of miRNA and lncRNAs in organ fibrosis and aging	73
The emerging roles of artificial intelligence in cancer drug development and precision therapy	73
A review on development of MUC1-based cancer vaccine	73
Tocilizumab combined with favipiravir in the treatment of COVID-19: A multicenter trial in a small sample size	73
The antioxidant potential of different edible and medicinal mushrooms	72
Essential oils as anticancer agents: Potential role in malignancies, drug delivery mechanisms, and immune system enhancement	72
Dual role of microbiota-derived short-chain fatty acids on host and pathogen	72
SARS-CoV-2 microbiome dysbiosis linked disorders and possible probiotics role	72
Morin hydrate: A comprehensive review on novel natural dietary bioactive compound with versatile biological and pharmacological potential	71
The direct evidence and mechanism of traditional Chinese medicine treatment of COVID-19	71
Non-coding RNAs participate in the ischemia-reperfusion injury	71
Oxidative stress – Complex pathological issues concerning the hallmark of cardiovascular and metabolic disorders	70
Uric acid aggravates myocardial ischemia–reperfusion injury via ROS/NLRP3 pyroptosis pathway	70
Anti prostate cancer therapy: Aptamer-functionalized, curcumin and cabazitaxel co-delivered, tumor targeted lipid-polymer hybrid nanoparticles	69
Therapeutic mechanisms of traditional Chinese medicine to improve metabolic diseases via the gut microbiota	69
Apigenin ameliorates doxorubicin-induced renal injury via inhibition of oxidative stress and inflammation	69
Curcumin and cardiovascular diseases: Focus on cellular targets and cascades	68
Curcumin regulates the differentiation of naïve CD4+T cells and activates IL-10 immune modulation against acute lung injury in mice	68
Traditional Chinese medicine formulas, extracts, and compounds promote angiogenesis	68
The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment	67
Mutations in SARS-CoV-2: Insights on structure, variants, vaccines, and biomedical interventions	67
Aptamers used for biosensors and targeted therapy	67
The effects of metformin on autophagy	67
Small rodent models of atherosclerosis	67
Natural therapeutics and nutraceuticals for lung diseases: Traditional significance, phytochemistry, and pharmacology	66
Nanotechnology-based drug delivery for central nervous system disorders	66
The potential of photodynamic therapy in current breast cancer treatment methodologies	66
Exploring the multifocal role of phytochemicals as immunomodulators	66
An updated role of astragaloside IV in heart failure	65
Diets and drugs for weight loss and health in obesity – An update	65
Natural components in sunscreens: Topical formulations with sun protection factor (SPF)	65
Plant-derived bioactive compounds in colon cancer treatment: An updated review	65
HDAC11: a rising star in epigenetics	65
Engineering of the current nucleoside-modified mRNA-LNP vaccines against SARS-CoV-2	65
Botany, traditional uses, phytochemistry, analytical methods, processing, pharmacology and pharmacokinetics of Bupleuri Radix: A systematic review	64
Macrophages in pancreatitis: Mechanisms and therapeutic potential	64
Chicory ameliorates hyperuricemia via modulating gut microbiota and alleviating LPS/TLR4 axis in quail	64
Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19	63
Nanomedicines: Redefining traditional medicine	63
The role of a ceRNA regulatory network based on lncRNA MALAT1 site in cancer progression	63
Quercetin for managing type 2 diabetes and its complications, an insight into multitarget therapy	63
Regulation of SIRT3 on mitochondrial functions and oxidative stress in Parkinson’s disease	63
N6-methyladenosine (m6A) methyltransferase WTAP accelerates the Warburg effect of gastric cancer through regulating HK2 stability	63
Recent advances in fructose intake and risk of hyperuricemia	63
Inhibition of Wnt/β-catenin pathway reverses multi-drug resistance and EMT in Oct4+/Nanog+ NSCLC cells	63
Potential effects of SARS-CoV-2 on the gastrointestinal tract and liver	62

When science goes viral: The research response during three months of the COVID-19 outbreak	62
RNA-based pharmacotherapy for tumors: From bench to clinic and back	62
The effect of Berberine on weight loss in order to prevent obesity: A systematic review	62
G-quadruplex stabilization via small-molecules as a potential anti-cancer strategy	62
Extraction, structure, and activity of polysaccharide from Radix astragali	62
Probiotic strain Lactobacillus plantarum YYC-3 prevents colon cancer in mice by regulating the tumour microenvironment	62
Link between microbiota and hypertension: Focus on LPS/TLR4 pathway in endothelial dysfunction and vascular inflammation, and therapeutic implication of probiotics	62
The molecular mechanisms of ferroptosis and its role in cardiovascular disease	62
Glyoxalase system: A systematic review of its biological activity, related-diseases, screening methods and small molecule regulators	62
The biological role of arachidonic acid 12-lipoxygenase (ALOX12) in various human diseases	62
Early use of non-steroidal anti-inflammatory drugs in COVID-19 might reverse pathogenesis, prevent complications and improve clinical outcomes	61
Actinidia chinensis Planch prevents proliferation and migration of gastric cancer associated with apoptosis, ferroptosis activation and mesenchymal phenotype suppression	61
RETRACTED: Healing potential of Spirulina platensis for skin wounds by modulating bFGF, VEGF, TGF-ß1 and α-SMA genes expression targeting angiogenesis and scar tissue formation in the rat model	61
Exploring the plant-derived bioactive substances as antidiabetic agent: An extensive review	61
The current understanding on the impact of KRAS on colorectal cancer	61
Emerging pharmacotherapies for COVID-19	61
The metastasizing mechanisms of lung cancer: Recent advances and therapeutic challenges	61
Ferritinophagy and ferroptosis in cardiovascular disease: Mechanisms and potential applications	61
Update on targeted cancer therapies, single or in combination, and their fine tuning for precision medicine	60
Tetramethylpyrazine: A review on its mechanisms and functions	60
The emerging molecular mechanism of m6A modulators in tumorigenesis and cancer progression	60
Salidroside as a potential neuroprotective agent for ischemic stroke: a review of sources, pharmacokinetics, mechanism and safety	60
The initiation of oxidative stress and therapeutic strategies in wound healing	60
Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases	59
Targeting SARS-CoV2 Spike Protein Receptor Binding Domain by Therapeutic Antibodies	59
Omicron variant (B.1.1.529) and its sublineages: What do we know so far amid the emergence of recombinant variants of SARS-CoV-2?	59
Counteracting role of nuclear factor erythroid 2-related factor 2 pathway in Alzheimer's disease	59
Protective effect of quercetin on streptozotocin-induced diabetic peripheral neuropathy rats through modulating gut microbiota and reactive oxygen species level	59
COVID-19 challenges and its therapeutics	59
A comprehensive review of natural products against atopic dermatitis: Flavonoids, alkaloids, terpenes, glycosides and other compounds	59
Phosphodiesterase 5 (PDE5): Structure-function regulation and therapeutic applications of inhibitors	58
Therapeutic potential of CAR T cell in malignancies: A scoping review	58
Itraconazole exerts anti-liver cancer potential through the Wnt, PI3K/AKT/mTOR, and ROS pathways	58
Beneficial effects of polysaccharide-rich extracts from Apocynum venetum leaves on hypoglycemic and gut microbiota in type 2 diabetic mice	58
Anti-inflammatory and anti-allergic potential of dietary flavonoids: A review	58
Cellular Red-Ox system in health and disease: The latest update	58
Glutamate excitotoxicity: Potential therapeutic target for ischemic stroke	58
Anti-cerebral ischemia reperfusion injury of polysaccharides: A review of the mechanisms	57
Research progress of traditional Chinese medicine against COVID-19	57
A traditional Chinese medicine formula NRICM101 to target COVID-19 through multiple pathways: A bedside-to-bench study	57
Breakthrough in targeted therapy for non-small cell lung cancer	56
Advances in the relationship between coronavirus infection and cardiovascular diseases	56
Anti-inflammatory and immunoregulatory effects of icariin and icaritin	56
Accelerated healing by topical administration of Salvia officinalis essential oil on Pseudomonas aeruginosa and Staphylococcus aureus infected wound model	56
Animal models of cerebral ischemia: A review	56
Recent advancements of nanoparticles application in cancer and neurodegenerative disorders: At a glance	55
A cross-talk between gut microbiome, salt and hypertension	55
Potential therapeutic natural products against Alzheimer's disease with Reference of Acetylcholinesterase	55
Anti-inflammatory phytochemicals for the treatment of diabetes and its complications: Lessons learned and future promise	55
Mitoquinone alleviates vincristine-induced neuropathic pain through inhibiting oxidative stress and apoptosis via the improvement of mitochondrial dysfunction	54
MAPK /ERK signaling pathway: A potential target for the treatment of intervertebral disc degeneration	54
Tomato (Solanum lycopersicum L.) seed: A review on bioactives and biomedical activities	54
Dihydrotestosterone-induced hair regrowth inhibition by activating androgen receptor in C57BL6 mice simulates androgenetic alopecia	54
Design and optimization of curcumin loaded nano lipid carrier system using Box-Behnken design	54
Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: A mechanism review	54
Long non-coding RNAs and exosomal lncRNAs: Potential functions in lung cancer progression, drug resistance and tumor microenvironment remodeling	54
Synergic effect of PD-1 blockade and endostar on the PI3K/AKT/mTOR-mediated autophagy and angiogenesis in Lewis lung carcinoma mouse model	54
Targets and strategies for vaccine development against SARS-CoV-2	54
Reactive oxygen species (ROS) in cancer pathogenesis and therapy: An update on the role of ROS in anticancer action of benzophenanthridine alkaloids	54
The pharmacological properties of chrysophanol, the recent advances	53
Mitochondria targeted peptide SS-31 prevent on cisplatin-induced acute kidney injury via regulating mitochondrial ROS-NLRP3 pathway	53
The emerging role of XBP1 in cancer	53
Gut microbiota-derived short-chain fatty acids and hypertension: Mechanism and treatment	53
Marine-derived drugs: Recent advances in cancer therapy and immune signaling	53
Genetics, pathophysiology, diagnosis, treatment, management, and prevention of migraine	53
Recent advances in management of COVID-19: A review	53
Galangin attenuates diabetic cardiomyopathy through modulating oxidative stress, inflammation and apoptosis in rats	53
Nanotechnology shaping stem cell therapy: Recent advances, application, challenges, and future outlook	53
Evidence and perspectives of cell senescence in neurodegenerative diseases	53
Peppermint essential oil: its phytochemistry, biological activity, pharmacological effect and application	53
MMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patients	53
Recent advances in heat shock proteins in cancer diagnosis, prognosis, metabolism and treatment	53
Effects of Polygonatum sibiricum saponin on hyperglycemia, gut microbiota composition and metabolic profiles in type 2 diabetes mice	53
The biological activities of butyrylcholinesterase inhibitors	53
Clusterin: Always protecting. Synthesis, function and potential issues	52
Exploring the journey of emodin as a potential neuroprotective agent: Novel therapeutic insights with molecular mechanism of action	52
Plantanone C attenuates LPS-stimulated inflammation by inhibiting NF-κB/iNOS/COX-2/MAPKs/Akt pathways in RAW 264.7 macrophages	52
The oncogenic role of Jagged1/Notch signaling in cancer	52
Pharmacological effects and mechanisms of tannic acid	52
Betulinic acid in the treatment of tumour diseases: Application and research progress	52
Advances in developing therapeutic strategies for Alzheimer's disease	52
Emerging mechanisms and applications of ferroptosis in the treatment of resistant cancers	52
Diacerein: Recent insight into pharmacological activities and molecular pathways	51
Cardioprotection of Panax Notoginseng saponins against acute myocardial infarction and heart failure through inducing autophagy	51
A review of the biological activity and pharmacology of cryptotanshinone, an important active constituent in Danshen	51
HCG18/miR-34a-5p/HMMR axis accelerates the progression of lung adenocarcinoma	51
The contribution of copper efflux transporters ATP7A and ATP7B to chemoresistance and personalized medicine in ovarian cancer	51
Inhibiting RRM2 to enhance the anticancer activity of chemotherapy	51
Natural products can be used in therapeutic management of COVID-19: Probable mechanistic insights	51
Advances in the treatment of Chagas disease: Promising new drugs, plants and targets	51
Site-specific targeted drug delivery systems for the treatment of inflammatory bowel disease	51
Protection against acute cerebral ischemia/reperfusion injury by QiShenYiQi via neuroinflammatory network mobilization	51
SARS-CoV-2 neutralizing antibody levels are correlated with severity of COVID-19 pneumonia	50
The potential use of simvastatin for cancer treatment: A review	50
Regulatory role of microRNAs on PTEN signaling	50