OOIR: Observatory of International Research

Papers

(The median citation count of Fundamental & Clinical Pharmacology is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Alamandin and especially melatonin attenuate pulmonary arterial hypertension induced by monocrotalin	57
Protective Effects of Cannabis sativa on chemotherapy‐induced nausea in a rat: Involvement of CB1 receptors	56
Can cannabidiol have an analgesic effect?	54
	50
Diarrhea and angiotensin II receptor blockers: Is there any difference between the different drugs?	31
In vitro evidence that the vasorelaxant effects of 2‐nitro‐1‐phenyl‐1‐propanol on rat coronary arteries involve cyclic nucleotide pathways	29
Novel ginsenoside monomer RT4 promotes colitis repair in mice by regulating miR‐144‐3p/SLC7A11 signaling pathway	27
Effects of clarithromycin on the pharmacokinetics of tacrolimus and expression of CYP3A4 and P‐glycoprotein in rats	23
Improvement of cognitive dysfunction by a novel phosphodiesterase type 5 inhibitor, Tadalafil	22
Inhibition of NorA efflux pump of Staphylococcus aureus by anacardic acids isolated from the cashew nutshell liquid of Anacardium occidentale L.	20
Effect of ceftriaxone on intestinal transit time	20
Calcium dobesilate protects against d‐galactose‐induced hepatic and renal dysfunction, oxidative stress, and pathological damage	18
Roflumilast improves resolution of sepsis‐induced acute kidney injury by retarding late phase renal interstitial immune cells infiltration and leakage in urinary sediments	18
Tofacitinib improved peripheral endothelial dysfunction and brain‐derived neurotrophic factor levels in the rat adjuvant‐induced arthritis model	17
Methylsulfonylmethane induces caspase‐dependent apoptosis in acute myeloid leukemia cell lines	17
	17
MiR‐199a‐3p in mouse bone marrow mesenchymal stem cell exosomes increases epithelial sodium channel expression in lung injury	17
Effects of FECH Gene Polymorphisms and Serum Ferrochelatase Levels on Antituberculosis Drug‐Induced Liver Injury in China	17
Cell therapy procedure using anti‐inflammatory macrophage M2 can potentially reduce Clinical Score in animals with Experimental Autoimmune Encephalomyelitis: A preclinical systematic review and meta‐a	15
Sakuranetin exerts anticonvulsant effect in bicuculline‐induced seizures	15
Relative bioavailability and pharmacokinetic comparison of a fixed‐dose combination tablet of mosapride, pancreatin, and simethicone relative to single‐component mosapride tablets in healthy Mexican s	15
Precipitation of sugammadex with nicardipine and labetalol: A laboratory research	14
Repurposing of atorvastatin and metformin denotes their individual and combined antiproliferative effects in non‐small cell lung cancer	14
Gemfibrozil, a lipid‐lowering drug, improves hepatorenal damages in a mouse model of aging	14
Issue Information	13

Metformin improves neurobehavioral impairments of streptozotocin‐treated and western diet‐fed mice: Beyond glucose‐lowering effects	13
Targeting autophagy with tamoxifen in breast cancer: From molecular mechanisms to targeted therapy	12
Evaluation of anti‐inflammatory activity of kaurenol: Experimental evaluation and mechanistic insights	12
Treatment implications of augmented renal clearance in a critically ill COVID‐19 patient: A case report	12
Master 2 Award	12
Cover Image, Volume 36, Issue 1	11
Histamine H1‐ and H2‐receptors participate to provide metabolic energy differently	11
Issue Information	11
UPLC‐MS analysis and network pharmacology‐based investigation into the active ingredients and molecular mechanisms of anti‐fatigue of male flowers with Eucommia ulmoides Oliv.	11
Issue Information	11
Oxidative stress and mitochondrial dysfunction following traumatic brain injury: From mechanistic view to targeted therapeutic opportunities	10
Sitagliptin's renoprotective effect in a diabetic nephropathy model in rats: The potential role of PI3K/AKT pathway	10
Population pharmacokinetics of mycophenolate in patients treated for interstitial lung disease (EVER‐ILD study)	10
Master 2 award	10
Chlorogenic acid co‐administration alleviates cisplatin‐induced peripheral neuropathy in rats	10
Vestibular disorders following BNT162b2 mRNA COVID‐19 vaccination: A retrospective case series	10
Thesis awards	10
Acetazolamide suppresses the progression of hepatocellular carcinoma induced by diethylnitrosamine in Wistar albino rats	10
Spontaneous reporting of adverse drug reactions as an outlet for patient dismay? The case of Levothyrox® change of excipients	10
Issue Information	9
Capivasertib augments chemotherapy via Akt inhibition in preclinical small cell lung cancer models	9
Chemsex practice in France: An update in Addictovigilance data	9
Necrostatin‐1 attenuates oral squamous cell carcinoma by modulating tumour immune response in mice	9
Vitamin D lacks efficacy: A re‐analysis of a systematic review using the REB method	9
Issue Information	9
	9
A novel naphthylchalcone ([E]‐4‐(3‐[naphthalen‐2‐yl]‐3‐oxoprop‐1‐en‐1‐yl) induces intrinsic and extrinsic apoptosis in human acute leukemia cell lines	9
	8
Theme and main topic index	8
Inhibition of plasminogen suppresses fibrosis and macrophage foaming in a nonalcoholic steatohepatitis mouse model	8
Use of real‐world evidence in translational pharmacology research	8
Inhibition of kidney potassium channels by fluoxetine: In vivo and in vitro studies	8
Bupivacaine inhibits the TLR4‐ and TLR2‐Myd88/NF‐κB pathways in human leukocytes	8
A comprehensive view on the quercetin impact on bladder cancer: Focusing on oxidative stress, cellular, and molecular mechanisms	8
Differential expression and activities of cytochrome P450 3A in the rat brain microsomes and mitochondria	8
	8
Animal models for the evaluation of antipsychotic agents	8
Association between immune‐related adverse events and prognosis in patients treated with immune checkpoint inhibitors in melanoma: A surrogacy analysis	8
Therapeutic targeting of DNA damage repair pathways guided by homologous recombination deficiency scoring in ovarian cancers	8
The protective effect of 3‐indolepropanoic acid on aflatoxin B1‐induced systemic perturbation of the liver and kidney function in rats	8
	8
Anti‐oxidative and anti‐neuroinflammatory role of Necrostatin‐1s and docosahexaenoic acid in RIP‐1‐mediated neurotoxicity in MPTP‐induced Parkinson's disease model	8
Oral communication abstracts	7
	7
Advances in the phytochemical screening and biological potential of propolis	7
Deliberation on debilitating condition of cancer cachexia: Skeletal muscle wasting	7
Atorvastatin ameliorates α‐KGDH and GDH functions in rats with diet‐induced hypercholesterolemia	7
Vitamin D3 potentiates the nephroprotective effects of vildagliptin–metformin combination in a rat model of metabolic syndrome	7
Issue Information	7
Effect of a high‐fat meal on the relative bioavailability of HMPL‐689 in Chinese healthy volunteers	7

A systematic strategy for investigating the pharmacological effects and mechanism of traditional Chinese medicinal formula: Guilin Xiguashuang as a case	7
Involvement of different K⁺ channel subtypes in hydrogen sulfide‐induced vasorelaxation of human internal mammary artery	7
	7
Effects of nalbuphine on the cardiotoxicity of ropivacaine in rats	7
Discussed Poster Abstracts – PM2	7
Benzimidazole derivatives: A versatile scaffold for drug development against Helicobacter pylori‐related diseases	7
Antihypertensive and lipid‐lowering drugs usage after primary stroke in a large representative sample of the French population	7
Adrenaline enhances nociceptive and motor blockades by intrathecal carteolol and oxprenolol in rats	7
Prospective pilot study evaluating a vitamin D3 loading dose in critically ill children with vitamin D deficiency	7
The vascular impact of dapagliflozin, liraglutide, and atorvastatin alone or in combinations in type 2 diabetic rat model	6
Recognition of potential therapeutic role of 2‐hydroxy‐3‐methylanthraquinones in the treatment of gallbladder carcinoma: A proteomics analysis	6
Master 2 award	6
The effects of cannabidiol on subjective states, cognition, and psychomotor function in healthy adults: A randomized clinical trial	6
Update on monkeypox virus infection: Focusing current treatment and prevention approaches	6
Oral Communication Abstracts	6
Borolatonin limits cognitive deficit and neuron loss while increasing proBDNF in ovariectomised rats	6
Drug‐induced radiation recall reactions and non‐anticancer drugs: A descriptive analysis from VigiBase®	6
Lacosamide use during breastfeeding: A case report and a literature review	6
Prevalence of medication administration errors in hospitalized adults: A systematic review and meta‐analysis up to 2017 to explore sources of heterogeneity	6
Chronic polypharmacy at all age: A population‐based drug utilization study	6
Inflammatory molecules facilitate the development of docetaxel‐resistant prostate cancer cells in vitro and in vivo	6
Drug news and therapeutic news	6
Discussed Poster Abstracts – PM1	6
	6
Issue Information	6
LQM10, a guanylhydrazone derivative, reduces nociceptive and inflammatory responses in mice	5
JAK/STAT inhibitors mitigate sepsis‐associated cerebral and cognitive injury	5
Thesis awards	5
ADMET study, spectroscopic characterization and effect of synthetic nitro chalcone in combination with norfloxacin, ciprofloxacin, and ethidium bromide against Staphylococcus aureus	5
A mini‐review on anticancer‐related properties of azithromycin and its potential activities in overcoming the challenges of glioblastoma	5
Angiotensin receptor–neprilysin inhibitor (thiorphan/irbesartan) improved cardiac function in a rat model of myocardial ischemic reperfusion injury	5
Antimanic‐like effect of dipyridamole in the methylphenidate‐induced hyperlocomotion	5
	5
Potentiation of antibiotic activity, and efflux pumps inhibition by (2E)‐1‐(4‐aminophenyl)‐3‐(4‐fluorophenyl)prop‐2‐en‐1‐one	5
Probing polypharmacy, ageing and sex effects on physical function using different tests	5
Potentiating‐antibiotic activity and absorption, distribution, metabolism, excretion and toxicity properties (ADMET) analysis of synthetic thiadiazines against multi‐drug resistant (MDR) strains	5
Development of a Bayesian estimation tool to determine the optimal duration of apixaban discontinuation before a high‐bleeding risk procedure	5
Edaravone dexborneol protects cerebral ischemia reperfusion injury through activating Nrf2/HO‐1 signaling pathway in mice	5
Is lithium neuroprotective? An updated mechanistic illustrated review	5
Afatinib triggers a Ni²⁺‐resistant Ca²⁺ influx pathway in A549 non‐small cell lung cancer cells	5
Pharmacokinetic and pharmacodynamic study of three products of epoetin alfa as single subcutaneous dose in healthy volunteers	5
Immunomodulator FTY720 improves glucose homeostasis and diabetic complications by rejuvenation of β‐cell function in nonhuman primate model of diabetes	5
Relapse and New‐Onset of Autoimmune or Inflammatory Diseases Following Vaccination With SPIKEVAX: Pharmacovigilance Overview From the French Spontaneous Reported System	5
Analgesic switching in chronic users of dextropropoxyphene in France	5
In vitro evidence that the anti‐inflammatory effect of synthetic cinnamate‐derived dienes is directly linked to a macrophage repolarization	5
Vortioxetine improved schizophrenia‐like behavioral deficits in a Poly I:C‐induced maternal immune activation model of schizophrenia in rats	5
Immunomodulatory effect of IL‐35 gene‐transfected mesenchymal stem cells on allergic asthma	5
Mechanism research on microRNA‐669f‐5p/deoxycytidylate deaminase axis mediating sevoflurane‐induced cognitive dysfunction in aged mice	5
Issue Information	4
Issue Information	4
Knockdown of RFC3 enhances the sensitivity of colon cancer cells to oxaliplatin by inducing ferroptosis	4
Drug news and therapeutic news	4
(−)‐Epicatechin improves body composition of male rats descendant of obese mothers postnatally fed with a high‐fat diet	4
Antinociceptive, anxiolytic, and depression‐like effects of hydrogen sulfide, nitric oxide, and carbon monoxide in rats and the role of opioidergic and serotonergic systems in antinociceptive activity	4
Pro‐inflammatory cytokines mediating senescence of vascular endothelial cells in atherosclerosis	4
Trends in adverse drug reactions related to oral weak opioid analgesics in therapeutic use in adults: A 10‐year French vigilances retrospective study	4
Issue Information	4
Issue Information	4
Insights into nanostructured lipid carriers of etoricoxib for mitigating radiation‐induced lung inflammation and exploring anti‐inflammatory mechanisms in rats	4
Population pharmacokinetics of sivelestat in Chinese patients with severe pneumonia	4
Study of prescription‐indication of tetracyclines in a population in Colombia	4
Interaction of buspirone and its major metabolites with human organic cation transporters	4
K_ATP channels are regulators of programmed cell death and targets for the creation of novel drugs against ischemia/reperfusion cardiac injury	4
The role of β‐adrenergic receptors in the regulation of cardiac tolerance to ischemia/reperfusion. Why do β‐adrenergic receptor agonists and antagonists protect the heart?	4
Buprenorphine exposures in adolescents and adults: A 10‐year experience of a French Poison Control Center	4
Pharmacological treatment for mental health illnesses in adults receiving dialysis: A scoping review	4
Second primary cancers and hormonal therapies for prostate cancer: A nested case–control study	4
Latest advances in the reversal strategies for direct oral anticoagulants	4
Patch testing versus interferon‐gamma release assay in evaluation of drug eruptions	4
Busulfan induces steatosis in HepaRG cells but not in primary human hepatocytes: Possible explanations and implication for the prediction of drug‐induced liver injury	4
Cannabinoids and Adverse Convulsive Effects: A Pharmacovigilance and Addictovigilance Analysis of Cases Reported in France	4
Fundamental and Clinical Pharmacology of drug repositioning	4
Exploring the therapeutic potential of Modafinil in mitigating renal ischemia–reperfusion injury in rats	3
Theme and main topic index	3
Issue Information	3
Effects of the nerve growth factor and its carrier protein on the inflammatory response from human monocytes	3
Prognostic roles of dysregulated METTL3 protein expression in cancers and potential anticancer value by inhibiting METTL3 function	3
DPD Ultra‐Rapid Metabolizer Status and Efficacy of 5‐Fluorouracil Treatment: A Real‐World Study	3
Sodium‐glucose cotransporter‐2 inhibitor (SGLT2i) plus glucagon‐like peptide type 1 receptor combination is more effective than SGLT2i plus dipeptidyl peptidase‐4 inhibitor combination in treating obe	3
Drug Exposure in Chronic Kidney Disease: It Is Not Just About the Glomerular Filtration Rate	3

Standardized study of atorvastatin possible osteoarthritis disease‐modifying effect in a rat model of osteoarthritis	3
Advances on pharmacology and toxicology of aconitine	3
The protective effect of pregabalin and xanthenone on testicular ischemia/reperfusion injury in rats	3
Heterogeneity in protocols and outcomes to study the effect of renin‐angiotensin system blockers in inflammatory bowel disease: A systematic review	3
Evaluation of potential antiviral activities of antimicrobial peptides in fish mucus	3
Issue Information	3
Discussed poster abstracts—PM1	3
Bezafibrate mitigates oxidized‐low density lipoprotein (ox‐LDL)‐induced the attachment of monocytes to endothelial cells: An implication in atherosclerosis	3
Intradermal testing of iodinated contrast media: Should we test up to pure or with diluted compounds only?	3
Issue Information	3
Photobiological effect of eugenol‐derived 3‐benzoylcoumarin associated with led lights against MDR microorganisms	3
Telmisartan: An angiotensin receptor blocker regulates osteoclastogenesis via inhibition of the ERK triggering in osteoporotic male rats	3
	3
Pentosan polysulfate exerts anti‐inflammatory effect and halts albuminuria progression in diabetic nephropathy: Role of combined losartan	3
Glibenclamide promoted functional recovery following sciatic nerve injury in male Wistar rats	3
Hesperidin improves physiological outcomes in an arginine vasopressin rat model of pre‐eclampsia	3
Pre‐treatment or post‐treatment with hydroxychloroquine demonstrates neuroprotective effects in cerebral ischemia/reperfusion	3
Issue Information	3
FKA‐A NPs enhances PTX‐A NPs efficacy to suppress ovarian cancer via regulating Skp2/YAP pathway	3
	3
Fluvoxamine Attenuates Liver Injury in Lipopolysaccharide‐Induced Sepsis: Via Nrf2/HO‐1 Pathway	3
Issue Information	3
	3
Investigating the link between drug consumption and adverse events reporting in France	3
Physiologically Based Pharmacokinetic modelling of drugs in pregnancy: A mini‐review on availability and limitations	3
Alterations in the gene expression of SARS‐COV‐2 entry receptors and enzymes in lungs and hearts of controlled and uncontrolled diabetic mice	3
Role of biomarkers and molecular signaling pathways in acute lung injury	3
Author index	3
	2
Molecular mechanisms of Alzheimer's disease: From therapeutic targets to promising drugs	2
Evidence that the anti‐inflammatory effect of 4‐aryl‐4H‐chromenes is linked to macrophage repolarization	2
The synergy between alkylating agents and ERCC1–XPF inhibitors is p53 dependent	2
Hypoglycemic effect on adult zebrafish (Danio rerio) of the 3β‐6β‐16β‐trihydroxylup‐20(29)‐ene triterpene isolated from Combretum leprosum leaves in vivo and in silico approac	2
Challenges and opportunities of medicines for treating tendon inflammation and fibrosis: A comprehensive and mechanistic review	2
Issue Information	2
Effects of acute ethanol and/or diazepam exposure on immediate and delayed hippocampal metabolite levels in rats anesthetized with isoflurane	2
Dual ET_A‐ET_B receptor antagonism improves metabolic syndrome‐induced heart failure with preserved ejection fraction	2
Immunomodulatory effect of N‐acetyl‐seryl‐aspartyl‐proline and vasoactive intestinal peptide on chronic obstructive pulmonary disease pathophysiology	2
Discussed Poster Abstracts	2
The state of astragaloside IV research: A bibliometric and visualized analysis	2
Issue Information	2
Breastfeeding and contrast agents—A critical review and presentation of new aspects	2
Induction of Ca²⁺ signaling and cytotoxic responses of human lung fibroblasts upon an antihistamine drug oxatomide treatment and evaluating the protective effects of Ca²⁺ chelati	2
Wnt/beta‐catenin modulation: A promising frontier in chronic kidney disease management	2
Exogenous GalR2‐specific peptide agonist as a tool for treating myocardial ischemia/reperfusion injury	2
Efficacy and safety of topiramate for reducing impulsivity: A transdiagnostic systematic review and meta‐analysis of a common clinical use	2
Opening of mitochondrial permeability transition pore in cardiomyocytes: Is ferutinin a suitable tool for its assessment?	2
Sodium hypochlorite accident diagnosis and management: Analysis from the literature and the French pharmacovigilance database	2
Myrtenal exhibits cardioprotective effects by attenuating the pathological progression associated with myocardial infarction	2
Repurposing bosentan as an anticancer agent: EGFR/ERK/c‐Jun modulation inhibits NSCLC tumor growth	2
	2
Orexin receptors: Targets and applications	2
Role of angiotensin receptor blockers in the context of Alzheimer's disease	2
Isobolographic analysis of the ciprofloxacin–gentamicin combination against beta‐lactamase‐producing Staphylococcus aureus	2
Discussed Poster Abstracts – PM1	2
Chemsex in HIV pre‐exposure prophylaxis users: Assessment of mood disorders and addictive behavior	2
Issue Information	2
MNK/eIF4E inhibition overcomes anlotinib resistance in non‐small cell lung cancer	2