Fundamental & Clinical Pharmacology

Article	Citations
A systematic strategy for investigating the pharmacological effects and mechanism of traditional Chinese medicinal formula: Guilin Xiguashuang as a case	49
Diarrhea and angiotensin II receptor blockers: Is there any difference between the different drugs?	49
Verapamil downregulates iron uptake and upregulates divalent metal transporter 1 expression in H9C2 cardiomyocytes	45
Drug News and Therapeutic News	44
Issue Information	37
Relationship between common telomere length‐related genetic variations, telomere length, and risk of antituberculosis drug‐induced hepatotoxicity in Chinese Han population: As assessed for causality u	29
Opening of mitochondrial permeability transition pore in cardiomyocytes: Is ferutinin a suitable tool for its assessment?	28
The effect of microglial inhibition on the expression of BDNF, KCC2, and GABAA receptor before and after the establishment of CCI‐induced neuropathic pain model	27
Fluoxetine‐induced downregulation of circMap2k1 signaling cascade to improve neurological function after ischemic stroke	27
(−)‐Epicatechin improves body composition of male rats descendant of obese mothers postnatally fed with a high‐fat diet	19
Issue Information	17
Targeting cannabinoid receptor 2 (CB2) limits collagen production—An in vitro study in a primary culture of human fibroblasts	17
Effects of RS17053 on α1‐adrenoceptors in rat vas deferens and aorta	17
Towards therapeutic drug monitoring of mycophenolic acid in mucous membrane pemphigoid: A retrospective single‐centre study	17
Effects of acute ethanol and/or diazepam exposure on immediate and delayed hippocampal metabolite levels in rats anesthetized with isoflurane	16
Issue Information	16
COVID‐19 in DMARD‐treated patients with inflammatory rheumatic diseases: Insights from an analysis of the World Health Organization pharmacovigilance database	15
Sevoflurane and isoflurane anesthesia induce redox imbalance, but only sevoflurane impairs vascular contraction	14
The N‐methyl‐D‐aspartate receptor antagonist ketamin exerts analgesic effects via modulation of the nitric oxide pathway	14
Cover Image, Volume 36, Issue 6	14
Enhancement of nerve regeneration with nimodipine treatment after sciatic nerve injury	13
Viral target and metabolism‐based rationale for combined use of recently authorized small molecule COVID‐19 medicines: Molnupiravir, nirmatrelvir, and remdesivir	13
Human neutrophil elastase inhibitors: Classification, biological‐synthetic sources and their relevance in related diseases	12
NVX‐Cov2373 Novavax Covid‐19 vaccine: A further analysis of its efficacy using multiple modes of expression	11
Antihypertensive and lipid‐lowering drugs usage after primary stroke in a large representative sample of the French population	11

Deliberation on debilitating condition of cancer cachexia: Skeletal muscle wasting	10
Homoarginine in the cardiovascular system: Pathophysiology and recent developments	10
The role of β‐adrenergic receptors in the regulation of cardiac tolerance to ischemia/reperfusion. Why do β‐adrenergic receptor agonists and antagonists protect the heart?	10
Gout and Levodopa: An unknown adverse effect?	10
The HIV reverse transcriptase Inhibitor Tenofovir suppressed DMH/HFD‐induced colorectal cancer in Wistar rats	10
Melatonin has an inhibitory effect on MCF‐7 and MDA‐MB‐231 human breast cancer cell lines by inducing autophagy and apoptosis	10
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Prospective pilot study evaluating a vitamin D3 loading dose in critically ill children with vitamin D deficiency	10
Protective Effects of Cannabis sativa on chemotherapy‐induced nausea in a rat: Involvement of CB1 receptors	10
Dose‐dependent bidirectional pharmacological effects of vinorelbine‐based metronomic combination chemotherapy on tumor growth and metastasis and mechanisms in melanoma mouse model	9
Can cannabidiol have an analgesic effect?	9
Repurposing bosentan as an anticancer agent: EGFR/ERK/c‐Jun modulation inhibits NSCLC tumor growth	9
Changes in serotonin neurotransmission as assayed by microdialysis after acute, intermittent or chronic ethanol administration and withdrawal	9
In vitro evidence that the vasorelaxant effects of 2‐nitro‐1‐phenyl‐1‐propanol on rat coronary arteries involve cyclic nucleotide pathways	9
Orexin receptors: Targets and applications	9
Effect of a high‐fat meal on the relative bioavailability of HMPL‐689 in Chinese healthy volunteers	8
Changes in digoxin pharmacokinetics associated with hepatic P‐glycoprotein upregulation in rats with non‐alcoholic fatty liver disease	8
Fundamental and Clinical Pharmacology of drug repositioning	8
Location matters: Overlooked ethnic‐geographic effect in China and Austria on propofol/cisatracurium sex differences among a population pharmacokinetic/pharmacodynamic (PopPK/PD) covariate analysis in	8
Discussed Poster Abstracts – PM2	7
Ursodeoxycholic acid for preventing parenteral nutrition‐associated cholestasis in neonates: A systematic review and meta‐analysis	7
Author Index	7
Antidiabetic omarigliptin dilates rabbit aorta by activating voltage‐dependent K+ channels and the sarco/endoplasmic reticulum Ca2+‐ATPase pump	7
Benzimidazole derivatives: A versatile scaffold for drug development against Helicobacter pylori‐related diseases	7
Evidence that the anti‐inflammatory effect of 4‐aryl‐4H‐chromenes is linked to macrophage repolarization	7
Chemsex in HIV pre‐exposure prophylaxis users: Assessment of mood disorders and addictive behavior	7
Involvement of different K+ channel subtypes in hydrogen sulfide‐induced vasorelaxation of human internal mammary artery	7
The state of astragaloside IV research: A bibliometric and visualized analysis	7
Issue Information	7
Oral communication abstracts	7
Targeting mevalonate pathway by zoledronate ameliorated pulmonary fibrosis in a rat model: Promising therapy against post‐COVID‐19 pulmonary fibrosis	7
Theme and main topic index	7
Nociceptive TRP channels function as molecular target for several antifungal drugs	7
Prognostic roles of dysregulated METTL3 protein expression in cancers and potential anticancer value by inhibiting METTL3 function	7
Dihydroartemisinin inhibits angiogenesis in breast cancer via regulating VEGF and MMP‐2/‐9	6
Evaluation of the anti‐inflammatory effect of 1,4‐dihydropyridine derivatives	6
Discussed Poster Abstracts – PM1	6
Calcium dobesilate protects against d‐galactose‐induced hepatic and renal dysfunction, oxidative stress, and pathological damage	6
Alamandin and especially melatonin attenuate pulmonary arterial hypertension induced by monocrotalin	6
Effect of sacubitril/valsartan on cognitive impairment in colchicine‐induced Alzheimer's model in rats	6
Antihyperlipidemic effect of selected pyrimidine derivatives mediated through multiple pathways	6
Drug news and therapeutic news	6
Adrenaline enhances nociceptive and motor blockades by intrathecal carteolol and oxprenolol in rats	6
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Effect of food intake on the pharmacokinetics of rivoceranib in healthy subjects	6
Doctor shopping for methylphenidate as a proxy for misuse and potential abuse in the 67 million inhabitants in France	5
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Methylsulfonylmethane induces caspase‐dependent apoptosis in acute myeloid leukemia cell lines	5
The effects of cannabidiol on subjective states, cognition, and psychomotor function in healthy adults: A randomized clinical trial	5
Issue Information	5

Isobolographic analysis of the ciprofloxacin–gentamicin combination against beta‐lactamase‐producing Staphylococcus aureus	5
Diarrhoea with the angiotensin receptor neprilysin inhibitor sacubitril + valsartan: A pharmacovigilance study	5
Wnt/beta‐catenin modulation: A promising frontier in chronic kidney disease management	5
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The synthesis and antineoplastic activities of thiaziridine, sulfidometylphosphonium, and dithiaphosphitane‐sulfide against the Ehrlich ascites carcinoma	5
Effects of clarithromycin on the pharmacokinetics of tacrolimus and expression of CYP3A4 and P‐glycoprotein in rats	5
Induction of Ca2+ signaling and cytotoxic responses of human lung fibroblasts upon an antihistamine drug oxatomide treatment and evaluating the protective effects of Ca2+ chelati	5
Exogenous GalR2‐specific peptide agonist as a tool for treating myocardial ischemia/reperfusion injury	5
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Oral Communication Abstracts	5
Oral Communication Abstracts	5
Hypoglycemic effect on adult zebrafish (Danio rerio) of the 3β‐6β‐16β‐trihydroxylup‐20(29)‐ene triterpene isolated from Combretum leprosum leaves in vivo and in silico approac	5
Issue Information	5
Breastfeeding and contrast agents—A critical review and presentation of new aspects	5
High glucose upregulates PAR‐1 in SH‐SY5Y cells via deficiency of miR‐20a and miR‐190a	5
Characterization of benzodiazepine misuse and comorbidities in patients with alcohol use disorder	5
Improvement of cognitive dysfunction by a novel phosphodiesterase type 5 inhibitor, Tadalafil	5
Drug‐induced radiation recall reactions and non‐anticancer drugs: A descriptive analysis from VigiBase®	5
Preclinical evidence of the anti‐inflammatory effect and toxicological safety of aryl‐cyclohexanone in vivo	5
Effect of ceftriaxone on intestinal transit time	4
An exploratory study of drug concentration and inhibitory effect of cetylpyridinium chloride buccal tablets on SARS‐CoV‐2 infection among 10 Chinese subjects	4
Activation of the Mas receptors by AVE0991 and MrgD receptor using alamandine to limit the deleterious effects of Ang II‐induced hypertension	4
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Antidepressants with anti‐tumor potential in treating glioblastoma: A narrative review	4
FKA‐A NPs enhances PTX‐A NPs efficacy to suppress ovarian cancer via regulating Skp2/YAP pathway	4
Effects of the nerve growth factor and its carrier protein on the inflammatory response from human monocytes	4
Role of angiotensin receptor blockers in the context of Alzheimer's disease	4
Bezafibrate mitigates oxidized‐low density lipoprotein (ox‐LDL)‐induced the attachment of monocytes to endothelial cells: An implication in atherosclerosis	4
Update on monkeypox virus infection: Focusing current treatment and prevention approaches	4
Efficacy of COVID‐19 vaccines: Several modes of expression should be presented in scientific publications	4
Population pharmacokinetics and pharmacodynamics of nirmatrelvir in Chinese patients with COVID‐19	4
Lacosamide‐induced personality changes: An unexpected adverse effect	4
Drug news and therapeutic news	4
Novel ginsenoside monomer RT4 promotes colitis repair in mice by regulating miR‐144‐3p/SLC7A11 signaling pathway	4
Lacosamide use during breastfeeding: A case report and a literature review	4
Discussed Poster Abstracts – PM1	4
Inhibition MNK‐eIF4E‐β‐catenin preferentially sensitizes gastric cancer to chemotherapy	4
Compound K: A systematic review of its anticancer properties and probable mechanisms	4
MiR‐199a‐3p in mouse bone marrow mesenchymal stem cell exosomes increases epithelial sodium channel expression in lung injury	4
Roflumilast improves resolution of sepsis‐induced acute kidney injury by retarding late phase renal interstitial immune cells infiltration and leakage in urinary sediments	4
Inhibition of NorA efflux pump of Staphylococcus aureus by anacardic acids isolated from the cashew nutshell liquid of Anacardium occidentale L.	4
Dosing‐time, feeding, and sex‐dependent variations of everolimus pharmacokinetics in mice	4
Naphazoline and oxymetazoline are superior to epinephrine in enhancing the cutaneous analgesia of lidocaine in rats	4
Angiotensin aldosterone inhibitors improve survival and ameliorate kidney injury induced by sepsis through suppression of inflammation and apoptosis	4
Challenges and opportunities of medicines for treating tendon inflammation and fibrosis: A comprehensive and mechanistic review	4
Melatonin as a complementary and prophylactic agent against COVID‐19 in high‐risk populations: A narrative review of recent findings from clinical and preclinical studies	4
Molecular toxicological alterations in the mouse hearts induced by sub‐chronic thiazolidinedione drugs administration	4
Issue Information	3
The synergy between alkylating agents and ERCC1–XPF inhibitors is p53 dependent	3
Impact of medication reviews on drug‐related problems (DRPs) in older patients living in nursing homes in West Occitania	3
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A comparative study between angiotensin receptor neprilysin inhibitor (thiorphan/irbesartan) with each of nitrate and carvedilol in a rat model of myocardial ischemic reperfusion injury	3
Advances on pharmacology and toxicology of aconitine	3
Intradermal testing of iodinated contrast media: Should we test up to pure or with diluted compounds only?	3
Survey the effect of drug treatment on modulation of cytokines gene expression in allergic rhinitis	3
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Standardized study of atorvastatin possible osteoarthritis disease‐modifying effect in a rat model of osteoarthritis	3
Inhibitory effects and molecular mechanisms of ginsenoside Rg1 on the senescence of hematopoietic stem cells	3
Poster Abstracts	3
Sakuranetin exerts anticonvulsant effect in bicuculline‐induced seizures	3
Chronic polypharmacy at all age: A population‐based drug utilization study	3
Issue Information	3
Antimalarial activities of benzothiazole analogs: A systematic review	3
Repurposing of atorvastatin and metformin denotes their individual and combined antiproliferative effects in non‐small cell lung cancer	3
Angiotensin 1–7 increases cardiac tolerance to ischemia/reperfusion and mitigates adverse remodeling of the heart—The signaling mechanism	3
Tofacitinib improved peripheral endothelial dysfunction and brain‐derived neurotrophic factor levels in the rat adjuvant‐induced arthritis model	3
Precipitation of sugammadex with nicardipine and labetalol: A laboratory research	3
Issue Information	3
The protective effect of α7‐nACh receptor and its interaction with 5‐HT1B/1D receptors in acute intestinal ischemia‐reperfusion injury in rats	3
The numerical probability of carcinogenicity to humans of some pharmaceutical drugs: Alkylating agents, topoisomerase inhibitors or poisons, and DNA intercalators	3
Breast cancer resistance protein polymorphism ABCG2 c.421C>A (rs2231142) moderates the effect of valproate on lamotrigine trough concentrations in adults with epilepsy	3
Relative bioavailability and pharmacokinetic comparison of a fixed‐dose combination tablet of mosapride, pancreatin, and simethicone relative to single‐component mosapride tablets in healthy Mexican s	3
Clinical pharmacology: Current innovations and future challenges	3
Theme and main topic index	3
Impacts of genetic polymorphisms and cancer cachexia on naldemedine pharmacokinetics and bowel movements in patients receiving opioid analgesics	3
Role of NIMA‐related kinase 2 in lung cancer: Mechanisms and therapeutic prospects	3
Neuroprotective effects of riluzole in Alzheimer's disease: A comprehensive review	3
Tylophora indica (Burm. f.) Merr alleviates tracheal smooth muscle hyperresponsiveness in ovalbumin‐induced allergic‐asthma model in guinea‐pigs: Evidences from ex vivo, in silico and in vivo s	3
Receptor density influences the recruitment bias of aripiprazole and brexpiprazole at the dopamine D2L receptor	3
Treatment implications of augmented renal clearance in a critically ill COVID‐19 patient: A case report	3

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Issue Information	3
Issue Information	3
Pentosan polysulfate exerts anti‐inflammatory effect and halts albuminuria progression in diabetic nephropathy: Role of combined losartan	2
Sodium‐glucose cotransporter‐2 inhibitor (SGLT2i) plus glucagon‐like peptide type 1 receptor combination is more effective than SGLT2i plus dipeptidyl peptidase‐4 inhibitor combination in treating obe	2
N‐(benzylidene)‐2‐((2‐hydroxynaphthalen‐1‐yl)diazenyl)benzohydrazides (1‐2) (NCHDH and NTHDH) attenuate DMBA‐induced breast cancer via Nrf2/NF‐κB/apoptosis signaling	2
FTY‐720 alleviates diabetes‐induced liver injury by inhibiting oxidative stress and inflammation	2
Master 2 Award	2
Induction of a single dose of streptozotocin (50 mg) in rat model causes insulin resistance with type 2 diabetes mellitus	2
The vascular impact of dapagliflozin, liraglutide, and atorvastatin alone or in combinations in type 2 diabetic rat model	2
Investigation of the effect of sugammadex on glutamate‐induced neurotoxicity in C6 cell line and the roles played by nitric oxide and oxidative stress pathways	2
Prevalence of medication administration errors in hospitalized adults: A systematic review and meta‐analysis up to 2017 to explore sources of heterogeneity	2
The therapeutic effect of NRF2 activator, ezetimibe, in cardiac cachexia	2
Role of apoptosis and autophagy in folic acid‐induced cytotoxicity of human breast cancer cells in vitro	2
Cell therapy procedure using anti‐inflammatory macrophage M2 can potentially reduce Clinical Score in animals with Experimental Autoimmune Encephalomyelitis: A preclinical systematic review and meta‐a	2
Body mass index affects imatinib exposure: Real‐world evidence from TDM with adaptive dosing	2
Evaluation of anti‐inflammatory activity of kaurenol: Experimental evaluation and mechanistic insights	2
Antidepressants abuse in subjects with opioid use disorders: A 10‐year study in the French OPPIDUM program	2
Gemfibrozil, a lipid‐lowering drug, improves hepatorenal damages in a mouse model of aging	2
Targeting autophagy with tamoxifen in breast cancer: From molecular mechanisms to targeted therapy	2
Photobiological effect of eugenol‐derived 3‐benzoylcoumarin associated with led lights against MDR microorganisms	2
Sodium‐glucose cotransporter 2 inhibitors: A comprehensive review from cells to bedside	2
Metformin counters oxidative stress and mitigates adverse effects of radiation exposure: An overview	2
Poster Abstracts	2
Adverse effects of gender‐affirming hormonal therapy in transgender persons: Assessing reports in the French pharmacovigilance database	2
Activation of spinal ephrin‐B3/EphBs signaling induces hyperalgesia through a PLP‐mediated mechanism	2
Gemfibrozil, a lipid‐lowering drug, reduces anxiety, enhances memory, and improves brain oxidative stress in d‐galactose‐induced aging mice	2
RETRACTION: Mineralocorticoid receptor antagonist‐mediated cognitive improvement in a mouse model of Alzheimer's type: possible involvement of BDNF‐H2S‐Nrf2 signaling	2
Psychoactive substance use among students: A cross‐sectional analysis	2
Xanthotoxin enhances the anticonvulsant potency of levetiracetam and valproate in the 6‐Hz corneal stimulation model in mice	2
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Investigating the link between drug consumption and adverse events reporting in France	2
Borolatonin limits cognitive deficit and neuron loss while increasing proBDNF in ovariectomised rats	2
Intrahippocampal injection of a selective blocker of NMDA receptors containing the GluN2B subunit, Ro25‐6981, increases glutamate neurotransmission and induces antidepressant‐like effects	2
Detection of ketamine in the oral fluid of drivers in northeastern France during the years 2020–2023	2
Metformin improves neurobehavioral impairments of streptozotocin‐treated and western diet‐fed mice: Beyond glucose‐lowering effects	2
Pharmacological potential of zonisamide and Nigella sativa per se and combination in high‐impact trauma device‐induced traumatic brain injury in Drosophila melanogaster	2
Role of biomarkers and molecular signaling pathways in acute lung injury	2
Author index	2
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Recognition of potential therapeutic role of 2‐hydroxy‐3‐methylanthraquinones in the treatment of gallbladder carcinoma: A proteomics analysis	2
Phosphatidylinositol 3‐kinase signaling pathway and inflammatory bowel disease: Current status and future prospects	2
Effect of spermidine on long non‐coding RNAs MALAT1 in a rotenone induced‐rat model of Parkinson's disease	2
In vitro inhibition and molecular docking of a new ciprofloxacin‐chalcone against SARS‐CoV‐2 main protease	2
New ways to repurpose salmeterol in an animal model of fibromyalgia	2
Adenosine monophosphate‐regulated protein kinase inhibition modulates electrophysiological characteristics and calcium homeostasis of rabbit right ventricular outflow tract	2
Master 2 award	2
Discussed Poster Abstracts	1
Histamine H1‐ and H2‐receptors participate to provide metabolic energy differently	1
Spontaneous reporting of adverse drug reactions as an outlet for patient dismay? The case of Levothyrox® change of excipients	1
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Cover Image, Volume 36, Issue 1	1
Influence of chrysin on D‐galactose induced‐aging in mice: Up regulation of AMP kinase/liver kinase B1/peroxisome proliferator‐activated receptor‐γ coactivator 1‐α signaling pathway	1
Theme Index	1
Spermidine reduced neuropathic pain in chronic constriction injury‐induced peripheral neuropathy in rats	1
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Antagonistic, synergistic, and additive antibacterial interaction between ciprofloxacin and amoxicillin against Staphylococcus aureus	1
Antinociceptive effects of nortriptyline and desipramine hydrochloride in Speke's hinge‐back tortoise (Kinixys Spekii)	1
Potentiating‐antibiotic activity and absorption, distribution, metabolism, excretion and toxicity properties (ADMET) analysis of synthetic thiadiazines against multi‐drug resistant (MDR) strains	1
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Issue Information	1
Probing polypharmacy, ageing and sex effects on physical function using different tests	1
Issue Information	1
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Thesis Awards	1
Epothilone B loaded in acellular nerve allograft enhanced sciatic nerve regeneration in rats	1
Issue Information	1
Potentiation of antibiotic activity, and efflux pumps inhibition by (2E)‐1‐(4‐aminophenyl)‐3‐(4‐fluorophenyl)prop‐2‐en‐1‐one	1
Oral Communication Abstracts	1
Radiological evolution of progestogen‐induced meningioma: A monocentric retrospective study	1
Hesperidin improves physiological outcomes in an arginine vasopressin rat model of pre‐eclampsia	1
Vestibular disorders following BNT162b2 mRNA COVID‐19 vaccination: A retrospective case series	1
Fundamental and clinical neuropharmacology, a terra incognita with constantly expanding frontiers	1
Role of natural mTOR inhibitors in treatment of diabetes mellitus	1
Ferulic acid mitigates diabetic cardiomyopathy via modulation of metabolic abnormalities in cardiac tissues of diabetic rats	1
Oxidative stress and mitochondrial dysfunction following traumatic brain injury: From mechanistic view to targeted therapeutic opportunities	1
Theme and main topic index	1
Sitagliptin's renoprotective effect in a diabetic nephropathy model in rats: The potential role of PI3K/AKT pathway	1
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Competition in drug binding and … the race to equilibrium	1
Pre‐treatment or post‐treatment with hydroxychloroquine demonstrates neuroprotective effects in cerebral ischemia/reperfusion	1
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LQM10, a guanylhydrazone derivative, reduces nociceptive and inflammatory responses in mice	1
The comparison of the antidiabetic effects of exenatide, empagliflozin, quercetin, and combination of the drugs in type 2 diabetic rats	1
Neuroprotective effect of sumatriptan in pentylenetetrazole‐induced seizure is mediated through N‐methyl‐D‐aspartate/nitric oxide and cAMP response element‐binding protein signaling pathway	1
Novel indole retinoid derivative induces apoptosis and cell cycle arrest and modulates AKT and ERK signaling in HL‐60 cells	1
Analgesic switching in chronic users of dextropropoxyphene in France	1
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Pharmacokinetic and pharmacodynamic study of three products of epoetin alfa as single subcutaneous dose in healthy volunteers	1
Safety profile of hydroxychloroquine used off‐label for the treatment of patients with COVID‐19: A descriptive study based on EudraVigilance data	1
Use of the French national health insurance information system for research in the field of mental health: Systematic review and perspectives	1
Chlorogenic acid co‐administration alleviates cisplatin‐induced peripheral neuropathy in rats	1
Kappa‐opioid receptor‐mediated thermal analgesia evoked by the intrathecal administration of the chemokine CCL1 in mice	1
Comparison of the effects of losartan, captopril, angiotensin II type 2 receptor agonist compound 21, and MAS receptor agonist AVE 0991 on myocardial ischemia‐reperfusion necrosis in rats	1