OOIR: Observatory of International Research

Papers

(The median citation count of Fundamental & Clinical Pharmacology is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Alamandin and especially melatonin attenuate pulmonary arterial hypertension induced by monocrotalin	60
Diarrhea and angiotensin II receptor blockers: Is there any difference between the different drugs?	58
In vitro evidence that the vasorelaxant effects of 2‐nitro‐1‐phenyl‐1‐propanol on rat coronary arteries involve cyclic nucleotide pathways	56
	50
Protective Effects of Cannabis sativa on chemotherapy‐induced nausea in a rat: Involvement of CB1 receptors	31
Can cannabidiol have an analgesic effect?	30
Novel ginsenoside monomer RT4 promotes colitis repair in mice by regulating miR‐144‐3p/SLC7A11 signaling pathway	27
Effects of clarithromycin on the pharmacokinetics of tacrolimus and expression of CYP3A4 and P‐glycoprotein in rats	24
Methylsulfonylmethane induces caspase‐dependent apoptosis in acute myeloid leukemia cell lines	22
Improvement of cognitive dysfunction by a novel phosphodiesterase type 5 inhibitor, Tadalafil	22
Effects of FECH Gene Polymorphisms and Serum Ferrochelatase Levels on Antituberculosis Drug‐Induced Liver Injury in China	19
Effect of ceftriaxone on intestinal transit time	18
Inhibition of NorA efflux pump of Staphylococcus aureus by anacardic acids isolated from the cashew nutshell liquid of Anacardium occidentale L.	18
Calcium dobesilate protects against d‐galactose‐induced hepatic and renal dysfunction, oxidative stress, and pathological damage	17
MiR‐199a‐3p in mouse bone marrow mesenchymal stem cell exosomes increases epithelial sodium channel expression in lung injury	17
Relative bioavailability and pharmacokinetic comparison of a fixed‐dose combination tablet of mosapride, pancreatin, and simethicone relative to single‐component mosapride tablets in healthy Mexican s	17
	17
Tofacitinib improved peripheral endothelial dysfunction and brain‐derived neurotrophic factor levels in the rat adjuvant‐induced arthritis model	17
Sakuranetin exerts anticonvulsant effect in bicuculline‐induced seizures	15
Precipitation of sugammadex with nicardipine and labetalol: A laboratory research	15
Issue Information	14
Gemfibrozil, a lipid‐lowering drug, improves hepatorenal damages in a mouse model of aging	14
Evaluation of anti‐inflammatory activity of kaurenol: Experimental evaluation and mechanistic insights	14
Metformin improves neurobehavioral impairments of streptozotocin‐treated and western diet‐fed mice: Beyond glucose‐lowering effects	14
Master 2 Award	14

Repurposing of atorvastatin and metformin denotes their individual and combined antiproliferative effects in non‐small cell lung cancer	14
Targeting autophagy with tamoxifen in breast cancer: From molecular mechanisms to targeted therapy	13
Cell therapy procedure using anti‐inflammatory macrophage M2 can potentially reduce Clinical Score in animals with Experimental Autoimmune Encephalomyelitis: A preclinical systematic review and meta‐a	12
Treatment implications of augmented renal clearance in a critically ill COVID‐19 patient: A case report	12
Cover Image, Volume 36, Issue 1	12
Histamine H1‐ and H2‐receptors participate to provide metabolic energy differently	11
Issue Information	11
Spontaneous reporting of adverse drug reactions as an outlet for patient dismay? The case of Levothyrox® change of excipients	11
Issue Information	11
Population pharmacokinetics of mycophenolate in patients treated for interstitial lung disease (EVER‐ILD study)	10
Chlorogenic acid co‐administration alleviates cisplatin‐induced peripheral neuropathy in rats	10
Oxidative stress and mitochondrial dysfunction following traumatic brain injury: From mechanistic view to targeted therapeutic opportunities	10
Acetazolamide suppresses the progression of hepatocellular carcinoma induced by diethylnitrosamine in Wistar albino rats	10
Sitagliptin's renoprotective effect in a diabetic nephropathy model in rats: The potential role of PI3K/AKT pathway	10
Master 2 award	10
Vestibular disorders following BNT162b2 mRNA COVID‐19 vaccination: A retrospective case series	10
Thesis awards	10
UPLC‐MS analysis and network pharmacology‐based investigation into the active ingredients and molecular mechanisms of anti‐fatigue of male flowers with Eucommia ulmoides Oliv.	10
	9
Capivasertib augments chemotherapy via Akt inhibition in preclinical small cell lung cancer models	9
Chemsex practice in France: An update in Addictovigilance data	9
Issue Information	9
Issue Information	9
Theme and main topic index	9
A novel naphthylchalcone ([E]‐4‐(3‐[naphthalen‐2‐yl]‐3‐oxoprop‐1‐en‐1‐yl) induces intrinsic and extrinsic apoptosis in human acute leukemia cell lines	9
A comprehensive view on the quercetin impact on bladder cancer: Focusing on oxidative stress, cellular, and molecular mechanisms	9
Inhibition of plasminogen suppresses fibrosis and macrophage foaming in a nonalcoholic steatohepatitis mouse model	8
Vitamin D lacks efficacy: A re‐analysis of a systematic review using the REB method	8
Necrostatin‐1 attenuates oral squamous cell carcinoma by modulating tumour immune response in mice	8
Anti‐oxidative and anti‐neuroinflammatory role of Necrostatin‐1s and docosahexaenoic acid in RIP‐1‐mediated neurotoxicity in MPTP‐induced Parkinson's disease model	8
Effects of nalbuphine on the cardiotoxicity of ropivacaine in rats	8
Differential expression and activities of cytochrome P450 3A in the rat brain microsomes and mitochondria	8
Therapeutic targeting of DNA damage repair pathways guided by homologous recombination deficiency scoring in ovarian cancers	8
	8
Bupivacaine inhibits the TLR4‐ and TLR2‐Myd88/NF‐κB pathways in human leukocytes	8
	8
The protective effect of 3‐indolepropanoic acid on aflatoxin B1‐induced systemic perturbation of the liver and kidney function in rats	8
Use of real‐world evidence in translational pharmacology research	8
	8
Inhibition of kidney potassium channels by fluoxetine: In vivo and in vitro studies	8
Association between immune‐related adverse events and prognosis in patients treated with immune checkpoint inhibitors in melanoma: A surrogacy analysis	8
Advances in the phytochemical screening and biological potential of propolis	7
Animal models for the evaluation of antipsychotic agents	7
Deliberation on debilitating condition of cancer cachexia: Skeletal muscle wasting	7
Antihypertensive and lipid‐lowering drugs usage after primary stroke in a large representative sample of the French population	7
Benzimidazole derivatives: A versatile scaffold for drug development against Helicobacter pylori‐related diseases	7
Oral communication abstracts	7
Discussed Poster Abstracts – PM2	7
Prospective pilot study evaluating a vitamin D3 loading dose in critically ill children with vitamin D deficiency	7
Involvement of different K⁺ channel subtypes in hydrogen sulfide‐induced vasorelaxation of human internal mammary artery	7

Effect of a high‐fat meal on the relative bioavailability of HMPL‐689 in Chinese healthy volunteers	7
	7
Issue Information	7
Vitamin D3 potentiates the nephroprotective effects of vildagliptin–metformin combination in a rat model of metabolic syndrome	7
A systematic strategy for investigating the pharmacological effects and mechanism of traditional Chinese medicinal formula: Guilin Xiguashuang as a case	7
Adrenaline enhances nociceptive and motor blockades by intrathecal carteolol and oxprenolol in rats	7
Analgesic switching in chronic users of dextropropoxyphene in France	6
Chronic polypharmacy at all age: A population‐based drug utilization study	6
Tamsulosin Attenuates Cardiac Hypertrophy via Integrin‐Linked Kinase: Possible Mechanisms	6
The effects of cannabidiol on subjective states, cognition, and psychomotor function in healthy adults: A randomized clinical trial	6
Discussed Poster Abstracts – PM1	6
Potentiating‐antibiotic activity and absorption, distribution, metabolism, excretion and toxicity properties (ADMET) analysis of synthetic thiadiazines against multi‐drug resistant (MDR) strains	6
The vascular impact of dapagliflozin, liraglutide, and atorvastatin alone or in combinations in type 2 diabetic rat model	6
Oral Communication Abstracts	6
Borolatonin limits cognitive deficit and neuron loss while increasing proBDNF in ovariectomised rats	6
Master 2 award	6
	6
Lacosamide use during breastfeeding: A case report and a literature review	6
Prevalence of medication administration errors in hospitalized adults: A systematic review and meta‐analysis up to 2017 to explore sources of heterogeneity	6
Issue Information	6
Recognition of potential therapeutic role of 2‐hydroxy‐3‐methylanthraquinones in the treatment of gallbladder carcinoma: A proteomics analysis	6
	6
Atorvastatin ameliorates α‐KGDH and GDH functions in rats with diet‐induced hypercholesterolemia	6
Drug news and therapeutic news	6
Update on monkeypox virus infection: Focusing current treatment and prevention approaches	6
Drug‐induced radiation recall reactions and non‐anticancer drugs: A descriptive analysis from VigiBase®	6
Probing polypharmacy, ageing and sex effects on physical function using different tests	6
	5
Pharmacokinetic and pharmacodynamic study of three products of epoetin alfa as single subcutaneous dose in healthy volunteers	5
Relapse and New‐Onset of Autoimmune or Inflammatory Diseases Following Vaccination With SPIKEVAX: Pharmacovigilance Overview From the French Spontaneous Reported System	5
Drug news and therapeutic news	5
Afatinib triggers a Ni²⁺‐resistant Ca²⁺ influx pathway in A549 non‐small cell lung cancer cells	5
A mini‐review on anticancer‐related properties of azithromycin and its potential activities in overcoming the challenges of glioblastoma	5
Development of a Bayesian estimation tool to determine the optimal duration of apixaban discontinuation before a high‐bleeding risk procedure	5
Immunomodulator FTY720 improves glucose homeostasis and diabetic complications by rejuvenation of β‐cell function in nonhuman primate model of diabetes	5
Inflammatory molecules facilitate the development of docetaxel‐resistant prostate cancer cells in vitro and in vivo	5
LQM10, a guanylhydrazone derivative, reduces nociceptive and inflammatory responses in mice	5
Insights into nanostructured lipid carriers of etoricoxib for mitigating radiation‐induced lung inflammation and exploring anti‐inflammatory mechanisms in rats	5
Immunomodulatory effect of IL‐35 gene‐transfected mesenchymal stem cells on allergic asthma	5
In vitro evidence that the anti‐inflammatory effect of synthetic cinnamate‐derived dienes is directly linked to a macrophage repolarization	5
Population pharmacokinetics of sivelestat in Chinese patients with severe pneumonia	5
JAK/STAT inhibitors mitigate sepsis‐associated cerebral and cognitive injury	5
Is lithium neuroprotective? An updated mechanistic illustrated review	5
Potentiation of antibiotic activity, and efflux pumps inhibition by (2E)‐1‐(4‐aminophenyl)‐3‐(4‐fluorophenyl)prop‐2‐en‐1‐one	5
Knockdown of RFC3 enhances the sensitivity of colon cancer cells to oxaliplatin by inducing ferroptosis	5
Antimanic‐like effect of dipyridamole in the methylphenidate‐induced hyperlocomotion	5
ADMET study, spectroscopic characterization and effect of synthetic nitro chalcone in combination with norfloxacin, ciprofloxacin, and ethidium bromide against Staphylococcus aureus	5
Second primary cancers and hormonal therapies for prostate cancer: A nested case–control study	5
Thesis awards	5
Pharmacological treatment for mental health illnesses in adults receiving dialysis: A scoping review	4
Issue Information	4
Angiotensin receptor–neprilysin inhibitor (thiorphan/irbesartan) improved cardiac function in a rat model of myocardial ischemic reperfusion injury	4
Issue Information	4
Study of prescription‐indication of tetracyclines in a population in Colombia	4
Busulfan induces steatosis in HepaRG cells but not in primary human hepatocytes: Possible explanations and implication for the prediction of drug‐induced liver injury	4
The role of β‐adrenergic receptors in the regulation of cardiac tolerance to ischemia/reperfusion. Why do β‐adrenergic receptor agonists and antagonists protect the heart?	4
Fundamental and Clinical Pharmacology of drug repositioning	4
Trends in adverse drug reactions related to oral weak opioid analgesics in therapeutic use in adults: A 10‐year French vigilances retrospective study	4
Issue Information	4
Mechanism research on microRNA‐669f‐5p/deoxycytidylate deaminase axis mediating sevoflurane‐induced cognitive dysfunction in aged mice	4
Vortioxetine improved schizophrenia‐like behavioral deficits in a Poly I:C‐induced maternal immune activation model of schizophrenia in rats	4
Antinociceptive, anxiolytic, and depression‐like effects of hydrogen sulfide, nitric oxide, and carbon monoxide in rats and the role of opioidergic and serotonergic systems in antinociceptive activity	4
Cannabinoids and Adverse Convulsive Effects: A Pharmacovigilance and Addictovigilance Analysis of Cases Reported in France	4
Pro‐inflammatory cytokines mediating senescence of vascular endothelial cells in atherosclerosis	4
Prognostic roles of dysregulated METTL3 protein expression in cancers and potential anticancer value by inhibiting METTL3 function	4
Interaction of buspirone and its major metabolites with human organic cation transporters	4
Latest advances in the reversal strategies for direct oral anticoagulants	4
Issue Information	4
Edaravone dexborneol protects cerebral ischemia reperfusion injury through activating Nrf2/HO‐1 signaling pathway in mice	4
Patch testing versus interferon‐gamma release assay in evaluation of drug eruptions	4
K_ATP channels are regulators of programmed cell death and targets for the creation of novel drugs against ischemia/reperfusion cardiac injury	4
No Impact of Vancomycin MIC, AUC, or AUC/MIC in Enterococcus faecium Bacteremia	4
(−)‐Epicatechin improves body composition of male rats descendant of obese mothers postnatally fed with a high‐fat diet	4
Discussed poster abstracts—PM1	4
Evaluation of potential antiviral activities of antimicrobial peptides in fish mucus	3
Correction to “ABCB1, SLC22A1, COMT, and OPRM1 Genotypes: Study of Their Influence on Plasma Methadone Levels and Clinical Response to Methadone Maintenance Treatment in Op	3
Photobiological effect of eugenol‐derived 3‐benzoylcoumarin associated with led lights against MDR microorganisms	3
Standardized study of atorvastatin possible osteoarthritis disease‐modifying effect in a rat model of osteoarthritis	3
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Bezafibrate mitigates oxidized‐low density lipoprotein (ox‐LDL)‐induced the attachment of monocytes to endothelial cells: An implication in atherosclerosis	3

Issue Information	3
Hesperidin improves physiological outcomes in an arginine vasopressin rat model of pre‐eclampsia	3
The protective effect of pregabalin and xanthenone on testicular ischemia/reperfusion injury in rats	3
Drug Exposure in Chronic Kidney Disease: It Is Not Just About the Glomerular Filtration Rate	3
Exploring the therapeutic potential of Modafinil in mitigating renal ischemia–reperfusion injury in rats	3
Issue Information	3
Role of biomarkers and molecular signaling pathways in acute lung injury	3
Investigating the link between drug consumption and adverse events reporting in France	3
Pentosan polysulfate exerts anti‐inflammatory effect and halts albuminuria progression in diabetic nephropathy: Role of combined losartan	3
Effects of the nerve growth factor and its carrier protein on the inflammatory response from human monocytes	3
FKA‐A NPs enhances PTX‐A NPs efficacy to suppress ovarian cancer via regulating Skp2/YAP pathway	3
Issue Information	3
Repurposing Asparaginase Therapy to Target Cisplatin‐Resistant Cancer Cells	3
Heterogeneity in protocols and outcomes to study the effect of renin‐angiotensin system blockers in inflammatory bowel disease: A systematic review	3
Author index	3
Pre‐treatment or post‐treatment with hydroxychloroquine demonstrates neuroprotective effects in cerebral ischemia/reperfusion	3
Theme and main topic index	3
Intradermal testing of iodinated contrast media: Should we test up to pure or with diluted compounds only?	3
Issue Information	3
DPD Ultra‐Rapid Metabolizer Status and Efficacy of 5‐Fluorouracil Treatment: A Real‐World Study	3
Fluvoxamine Attenuates Liver Injury in Lipopolysaccharide‐Induced Sepsis: Via Nrf2/HO‐1 Pathway	3
Sodium‐glucose cotransporter‐2 inhibitor (SGLT2i) plus glucagon‐like peptide type 1 receptor combination is more effective than SGLT2i plus dipeptidyl peptidase‐4 inhibitor combination in treating obe	3
Advances on pharmacology and toxicology of aconitine	3
	3
Alterations in the gene expression of SARS‐COV‐2 entry receptors and enzymes in lungs and hearts of controlled and uncontrolled diabetic mice	3
Breastfeeding and contrast agents—A critical review and presentation of new aspects	2
Dual ET_A‐ET_B receptor antagonism improves metabolic syndrome‐induced heart failure with preserved ejection fraction	2
Issue Information	2
	2
Telmisartan: An angiotensin receptor blocker regulates osteoclastogenesis via inhibition of the ERK triggering in osteoporotic male rats	2
Repurposing bosentan as an anticancer agent: EGFR/ERK/c‐Jun modulation inhibits NSCLC tumor growth	2
Opening of mitochondrial permeability transition pore in cardiomyocytes: Is ferutinin a suitable tool for its assessment?	2
Hypoglycemic effect on adult zebrafish (Danio rerio) of the 3β‐6β‐16β‐trihydroxylup‐20(29)‐ene triterpene isolated from Combretum leprosum leaves in vivo and in silico approac	2
Exogenous GalR2‐specific peptide agonist as a tool for treating myocardial ischemia/reperfusion injury	2
The state of astragaloside IV research: A bibliometric and visualized analysis	2
Sodium hypochlorite accident diagnosis and management: Analysis from the literature and the French pharmacovigilance database	2
Myrtenal exhibits cardioprotective effects by attenuating the pathological progression associated with myocardial infarction	2
Discussed Poster Abstracts	2
Evidence that the anti‐inflammatory effect of 4‐aryl‐4H‐chromenes is linked to macrophage repolarization	2
Chemsex in HIV pre‐exposure prophylaxis users: Assessment of mood disorders and addictive behavior	2
Leveraging Fiber Photometry to Decipher Neural Circuits Underlying Anxiety in Mice	2
Isobolographic analysis of the ciprofloxacin–gentamicin combination against beta‐lactamase‐producing Staphylococcus aureus	2
Discussed Poster Abstracts – PM1	2
Orexin receptors: Targets and applications	2
Immunomodulatory effect of N‐acetyl‐seryl‐aspartyl‐proline and vasoactive intestinal peptide on chronic obstructive pulmonary disease pathophysiology	2
Molecular mechanisms of Alzheimer's disease: From therapeutic targets to promising drugs	2
Glibenclamide promoted functional recovery following sciatic nerve injury in male Wistar rats	2
Physiologically Based Pharmacokinetic modelling of drugs in pregnancy: A mini‐review on availability and limitations	2
MNK/eIF4E inhibition overcomes anlotinib resistance in non‐small cell lung cancer	2
Effects of acute ethanol and/or diazepam exposure on immediate and delayed hippocampal metabolite levels in rats anesthetized with isoflurane	2
Wnt/beta‐catenin modulation: A promising frontier in chronic kidney disease management	2
Induction of Ca²⁺ signaling and cytotoxic responses of human lung fibroblasts upon an antihistamine drug oxatomide treatment and evaluating the protective effects of Ca²⁺ chelati	2
Issue Information	2
	1
Effect of spermidine on long non‐coding RNAs MALAT1 in a rotenone induced‐rat model of Parkinson's disease	1
Optimization of application schedule of camphecene, a novel anti‐influenza compound, based on its pharmacokinetic characteristics	1
Metformin counters oxidative stress and mitigates adverse effects of radiation exposure: An overview	1
Role of angiotensin receptor blockers in the context of Alzheimer's disease	1
RETRACTION: Mineralocorticoid receptor antagonist‐mediated cognitive improvement in a mouse model of Alzheimer's type: possible involvement of BDNF‐H2S‐Nrf2 signaling	1
Sodium thiosulfate mitigates PM_2.5‐induced cardiotoxicity by preservation of mitochondrial function	1
Risperidone in analgesia induced by paracetamol and meloxicam in experimental pain	1
Pharmacological potential of the triterpene 3β,6β,16β‐trihidroxilup‐20 (29)‐ene isolated from Combretum leprosum: A literature review	1
Arterial hypertension associated with PARPi: A meta‐analysis of 41 placebo randomized controlled trials combined with a World Health Organization's pharmacovigilance study	1
Treatment with the combination of clavulanic acid and valproic acid led to recovery of neuronal and behavioral deficits in an epilepsy rat model	1
Repurposing synthetic and natural derivatives induces apoptosis in an orthotopic glioma‐induced xenograft model by modulating WNT/β‐catenin signaling	1
Epothilone B loaded in acellular nerve allograft enhanced sciatic nerve regeneration in rats	1
Issue Information	1
Issue Information	1
Psilocybin as Transformative Fast‐Acting Antidepressant: Pharmacological Properties and Molecular Mechanisms	1
Antimalarial activities of benzothiazole analogs: A systematic review	1
Homoarginine treatment of rats improves cardiac function and remodeling in response to pressure overload	1
Role of apoptosis and autophagy in folic acid‐induced cytotoxicity of human breast cancer cells in vitro	1
Challenges and opportunities of medicines for treating tendon inflammation and fibrosis: A comprehensive and mechanistic review	1
Evaluation of therapeutic potential of ivermectin against complete Freund's adjuvant‐induced arthritis in rats: Involvement of inflammatory mediators	1
Rapid high performance liquid chromatography method for erlotinib quantification in vitro: Application to study the effect of resveratrol on metabolism and cellular uptake of erlotinib	1
Relaxin‐2 mitigates the interaction between monocytes and endothelial cells by suppressing Egr‐1	1
Patterns of ketamine use among people with substance use disorder in France: Multisource analysis of the data from the French Addictovigilance Network	1
Drug–drug interactions of protein kinase inhibitors in chronic myeloid leukaemia patients: A study using the French health insurance database	1
Tyrosine kinase inhibitors and direct oral anticoagulants: In vitro evaluation of drug–drug interaction mediated by P‐glycoprotein	1
Neuroprotective effect of sumatriptan in pentylenetetrazole‐induced seizure is mediated through N‐methyl‐D‐aspartate/nitric oxide and cAMP response element‐binding protein signaling pathway	1
	1
Long‐term evaluation of rheumatoid arthritis activity with erythrocyte methotrexate‐polyglutamate 3	1
Activation of spinal ephrin‐B3/EphBs signaling induces hyperalgesia through a PLP‐mediated mechanism	1
Evaluation of combination therapies with colistin in an experimental mouse pneumonia model induced by carbapenem‐resistant Acinetobacter baumannii strain	1
Induction of a single dose of streptozotocin (50 mg) in rat model causes insulin resistance with type 2 diabetes mellitus	1
	1
Synthesis, molecular docking, ADMET, and evaluation of the anxiolytic effect in adult zebrafish of synthetic chalcone (E)‐3‐(4‐(dimethylamino)phenyl)‐1‐(2‐hydroxyphenyl)prop‐2‐en‐1‐one: An in v	1
The synergy between alkylating agents and ERCC1–XPF inhibitors is p53 dependent	1
Issue Information	1
Therapeutic Potential of 3‐(4‐Chlorophenyl)‐4‐(2‐Hydroxyphenyl) 1,3‐Oxazetidin‐2‐One in STZ‐Induced Diabetic Neuropathic Pain in Rats	1
Anticancer effect of propranolol on diethylnitrosamine‐induced hepatocellular carcinoma rat model	1
Therapeutic potentials of melatonin in the treatment of lymphoma: A review of current evidence	1
Preliminary evaluation of the efficacy and safety of brimonidine for deep sedation	1
Sitagliptin ameliorates diabetic nephropathy by upregulating renal nephrin and podocin expression through modulation of adipokines levels	1
New ways to repurpose salmeterol in an animal model of fibromyalgia	1