Physiological Research

Article	Citations
COVID-19 and the Immune System	228
The anti-obesity and health-promoting effects of tea and coffee	43
CCR5Δ32 Deletion as a Protective Factor in Czech First-Wave COVID-19 Subjects	33
Acute Lung Injury – From Pathophysiology to Treatment	30
The Role of Skeletal Muscle in The Pathogenesis of Altered Concentrations of Branched-Chain Amino Acids (Valine, Leucine, and Isoleucine) in Liver Cirrhosis, Diabetes, and Other Diseases	29
The Role of AMPK/mTOR Signaling Pathway in Anticancer Activity of Metformin	26
The Role of Nrf2 and PPARγ in the Improvement of Oxidative Stress in Hypertension and Cardiovascular Diseases	25
Alveolar Type II Cells and Pulmonary Surfactant in COVID-19 Era	24
Vitamin D3 Action Within the Ovary – an Updated Review	23
Endocrine Disruptors, Obesity, and Cytokines - How Relevant Are They to PCOS?	23
Hepatic Stellate Cell: A Double-Edged Sword in the Liver	20
Role of cytochrome c oxidase nuclear-encoded subunits in health and disease	20
Apelin-13 Regulates Angiotensin II-Induced Cx43 Downregulation and Autophagy via the AMPK/mTOR Signaling Pathway in HL-1 Cells	20
Iodine, Thyroglobulin and Thyroid Gland	19
Radiofrequency electromagnetic field affects heart rate variability in rabbits	17
Insights Into the Physiology of C-peptide	16
Pathophysiology of exercise-induced muscle damage and its structural, functional, metabolic, and clinical consequences	16
Coenzyme Q10 effects in neurological diseases	16
The potential applications of artificial intelligence in drug discovery and development	15
Side Effects of Amino Acid Supplements	15
Clinical implications of the glucokinase impaired function – GCK MODY today	14
The effects of spaceflight microgravity on the musculoskeletal system of humans and animals, with an emphasis on exercise as a countermeasure: a systematic scoping review	14
Dental Composites – a Low-Dose Source of Bisphenol A?	13
Eye pupil – a window into central autonomic regulation via emotional/cognitive processing	13
Interactions of Renin-Angiotensin System and COVID-19: The Importance of Daily Rhythms in ACE2, ADAM17 and TMPRSS2 Expression	13

Peroxisome Proliferator-Activated Receptor γ in White and Brown Adipocyte Regulation and Differentiation	13
Endocrine Disruptors and Gut Microbiome Interactions	13
COVID-19 and the Differences in Physiological Background Between Children and Adults and Their Clinical Consequences	12
Inhibitory Immune Checkpoint Molecules and Exhaustion of T cells in COVID-19	12
Aging, Hormones and Receptors	12
Cytokine Cascade in Kawasaki Disease Versus Kawasaki-Like Syndrome	12
Effect of iron oxide nanoparticles on vascular function and nitric oxide production in acute stress-exposed rats	12
Contribution of Selected Vasoactive Systems to Blood Pressure Regulation in Two Models of Chronic Kidney Disease	12
Could the Musk Compound Tonalide Affect Physiological Functions and Act as an Endocrine Disruptor in Rainbow Trout?	12
Phenotype and function of macrophage polarization in monocrotaline-induced pulmonary arterial hypertension rat model	12
Melanocortin Pathways: Suppressed and Stimulated Melanocortin-4 Receptor (MC4R)	12
MiR-133a-3p Relieves the Oxidative Stress Induced Trophoblast Cell Apoptosis Through the BACH1/Nrf2/HO-1 Signaling Pathway	12
Influence of Histidine Administration on Ammonia and Amino Acid Metabolism: A Review	11
Various Aspects of Sex and Gender Bias in Biomedical Research	11
COVID-19, Oxidative Stress, and Male Reproductive Dysfunctions: Is Vitamin C a Potential Remedy?	11
Methamphetamine, Neurotransmitters and Neurodevelopment	11
Parathyroid Hormone-Related Changes of Bone Structure	11
FSH, Oxytocin and IGF-I Regulate the Expression of Sirtuin 1 in Porcine Ovarian Granulosa Cells	11
(Pro)renin Receptor Contributes to Hypoxia/Reoxygenation-Induced Apoptosis and Autophagy in Myocardial Cells via the β-Catenin Signaling Pathway	10
Electroacupuncture inhibits the interaction between peripheral TRPV1 and P2X3 in rats with different pathological pain	10
Investigation of the properties and effects of salvia officinalis l. on the viability, steroidogenesis and Reactive Oxygen Species (ROS) production in TM3 leydig cells in vitro	9
Alternations in the cardiovascular autonomic regulation and growth factors in autism	9
Aluminum Oxide and Zinc Oxide Induced Nanotoxicity in Rat Brain, Heart, and Lung	9
Plasma asprosin, CCDC80 and ANGPTL4 levels are associated with metabolic and cardiovascular risk in patients with inflammatory bowel disease	9
Follicle stimulating hormone inhibits the expression of p53 up-regulated modulator of apoptosis induced by reactive oxygen species through PI3K/Akt in mouse granulosa cells	9
The effect of obesity, hypertension, diabetes mellitus, alcohol, and sleep apnea on the risk of atrial fibrillation	9
Steroids, steroid associated substances and gestational diabetes mellitus	8
Wnt/β-catenin signaling contributes to vincristine-induced neuropathic pain	8
Estradiol, Obesity and Hypogonadism	8
Men´s reproductive alterations caused by bisphenol A and its analogues: a review	8
Aspiration syndromes and associated lung injury: incidence, pathophysiology and management	8
miR-431-5p Regulates Apoptosis of Cardiomyocytes After Acute Myocardial Infarction via Targeting Selenoprotein T	8
Dynamic Changes of High-Sensitivity Troponin T Concentration During Infancy: Clinical Implications	8
Mitochondrial Respiration of Human Platelets in Young Adult and Advanced Age – Seahorse or O2k?	8
Hyperbaric oxygen influences chronic wound healing – a cellular level review	8
Glucocorticoids Affect Male Testicular Steroidogenesis	8
What Is a Hormone?	8
11-Keto-testosterone and Other Androgens of Adrenal Origin	8
Pediatric Inflammatory Multisystem Syndrome (PIMS) – Potential role for cytokines such Is IL-6	8
Pancreatic stellate cells - rising stars in pancreatic pathologies	8
Aspiration syndromes and associated lung injury: incidence, pathophysiology and management	8
Perinatal Hypoxic-Ischemic Damage: Review of the Current Treatment Possibilities	7
Cell-Free DNA as an Obesity Biomarker	7
Increasing veno-arterial extracorporeal membrane oxygenation flow reduces electrical impedance of the lung regions in porcine acute heart failure	7
Acellular Dermal Matrix in Plastic and Reconstructive Surgery	7
Treatment With Coenzyme Q10, ω-3-Polyunsaturated Fatty Acids and Their Combination Improved Bioenergetics and Levels of Coenzyme Q9 and Q10 in Skeletal Muscle Mitochondria in Experimental Model of Art	7
Edaravone Attenuates Disease Severity of Experimental Auto-Immune Encephalomyelitis and Increases Gene Expression of Nrf2 and HO-1	7
Review of the structural and functional brain changes associated with chronic kidney disease	7
Transient Receptor Potential Ankyrin 1 Channel: An Evolutionarily Tuned Thermosensor	7
Riboflavin Recovery of Spermatogenic Dysfunction via a Dual Inhibition of Oxidative Changes and Regulation of the PINK1-Mediated Pathway in Arsenic-Injured Rat Model	7

Portal hypertension is the main driver of liver stiffness in advanced liver cirrhosis	7
Herbal Compounds in the Treatment of Pulmonary Silicosis	7
Covid-19 Infection and the Host Genetic Predisposition: Does it Exist?	7
Purinoceptors, Renal Microvascular Function and Hypertension	7
Impact of Prenatal Hypoxia on the Development and Behavior of the Rat Offspring	6
Introduction to DOK2 and its Potential Role in Cancer	6
Low-Level Laser Therapy Attenuates Arthrogenic Contracture Induced by Anterior Cruciate Ligament Reconstruction Surgery in Rats	6
Functions of Sleep	6
Antioxidative Effect of Dietary Flavonoid Isoquercitrin on Human Ovarian Granulosa Cells HGL5 In Vitro	6
C-Reactive Protein, Chemerin, Fetuin-A and Osteopontin as Predictors of Cardiovascular Risks in Persons With Psoriasis Vulgaris	6
The effect of repeated passaging on the susceptibility of human proximal tubular HK-2 cells to toxic compounds	6
Study on the Regulation Mechanism of Lipopolysaccharide on Oxidative Stress and Lipid Metabolism of Bovine Mammary Epithelial Cells	6
Microbiota of female genital tract – functional overview of microbial flora from vagina to uterine tubes and placenta	6
Healthy microbiome – a mere idea or a sound concept?	6
Fluid Shear Stress Promotes Osteoblast Proliferation and Suppresses Mitochondrial-Mediated Osteoblast Apoptosis Through the miR-214-3p-ATF4 Signaling Axis	6
Plant extracellular vesicles and their potential in human health research, the practical approach	6
Impact of Aging on Mitochondrial Respiration in Various Organs	6
Sex Steroid Hormones in Depressive Disorders as a Basis for New Potential Treatment Strategies	6
miR-29a is a Potential Protective Factor for Fibrogenesis in Gluteal Muscle Contracture	6
Effects of Selected Inherited Factors on Susceptibility to SARS-CoV-2 Infection and COVID-19 Progression	6
Effects of Concentrated Growth Factor and Nanofat on Aging Skin of Nude Mice Induced by D-Galactose	6
The Effects of Titanium Topography and Chemical Composition on Human Osteoblast Cell	5
Pathophysiological Analysis of Uninephrectomized db/db Mice as a Model of Severe Diabetic Kidney Disease	5
Uterine Natural Killer Cells in the Context of Implantation: Immunohistochemical Analysis of Endometrial Samples from Women with Habitual Abortion and Recurrent Implantation Failure	5
Hydrogen sulfide protects against ischemic heart failure by inhibiting RIP1/RIP3/MLKL-mediated necroptosis	5
Variability of Peripheral Pulse Wave Velocity in Patients With Diabetes Mellitus Type 2 During Orthostatic Challenge	5
Cell-Type-Independent Expression of Inwardly Rectifying Potassium Currents in Mouse Fungiform Taste Bud Cells	5
The Combination of Atorvastatin With Silymarin Enhances Hypolipidemic, Antioxidant and Anti-Inflammatory Effects in a Rat Model of Metabolic Syndrome	5
Androgens in SARS-CoV-2 Coronavirus Infections	5
The Long-Term Effects of Growth Hormone Replacement on Bone Mineral Density and Trabecular Bone Score: Results of the 10-Year Prospective Follow-up	5
Beta-Adrenergic Receptors Gene Polymorphisms are Associated With Cardiac Contractility and Blood Pressure Variability	5
Myocardial m6A regulators in postnatal development: effect of sex	5
Cardiovascular Physiology and Pathophysiology in Down Syndrome	5
Fibroblast Growth Factor 23 and Klotho Are Associated With Trabecular Bone Score but Not Bone Mineral Density in the Early Stages of Chronic Kidney Disease: Results of the Cross-Sectional Study	5
Sensitivity of Zebrafish (Danio rerio) Embryos to Hospital Effluent Compared to Daphnia magna and Aliivibrio fischeri	5
The Use of Egocentric and Allocentric Reference Frames in Static and Dynamic Conditions in Humans	5
The Severity of Muscle Performance Deterioration in Sarcopenia Correlates With Circulating Muscle Tissue-Specific miRNAs	5
Inhibition of NADPH oxidase within midbrain periaqueductal gray decreases pain sensitivity in Parkinson's disease via GABAergic signaling pathway	5
Altered Expression of ORAI and STIM Isoforms in Activated Human Cardiac Fibroblasts	5
Midazolam and Its Effect on Vital Signs and Behavior in Children Under Conscious Sedation in Dentistry	5
The effect of Apium Graveolens L., Levisticum Officinale and Calendula Officinalis L. on cell viability, membrane integrity, steroidogenesis, and intercellular communication in mice Leydig cells in vi	5
Glucagon-like peptide-1 receptor agonist reduces di(2-ethylhexyl) phthalate-induced atherosclerotic processes in vascular smooth muscle cells	5
“Double-Edged Sword” Effect of Reactive Oxygen Species (ROS) in Tumor Development and Carcinogenesis	5
The effects of different types of exercise on circulating irisin levels in healthy individuals and in people with overweight, metabolic syndrome and type 2 diabetes	5
MiR-18a Inhibits PI3K/AKT Signaling Pathway to Regulate PDGF BB-Induced Airway Smooth Muscle Cell Proliferation and Phenotypic Transformation	5
Fibroblast Growth Factor 21 (FGF21) in Children and Adolescents With Chronic Kidney Disease	5
Progesterone Inhibitory Role on Gastrointestinal Motility	5
NMR Plasma Metabolomics Study of Patients Overcoming Acute Myocardial Infarction: in the First 12 h After Onset of Chest Pain With Statistical Discrimination Towards Metabolomic Biomarkers	4
The Effects of Wheel-Running Using the Upper Limbs Following Immobilization After Inducing Arthritis in the Knees of Rats	4
Short-Term Arterial Compliance Changes in the Context of Systolic Blood Pressure Influence	4
Combined Effect of Acute Altitude Exposure and Vigorous Exercise on Platelet Activation	4
Ovarian Reserve Assessed by the Anti-Mullerian Hormone and Reproductive Health Parameters in Women With Crohn´s Disease, a Case-Control Study	4
Effect of Methylprednisolone on Experimental Brain Edema in Magnetic Resonance Imaging	4
Pathophysiological Characteristics Linking Type 2 Diabetes Mellitus and Colorectal Neoplasia	4
Application of Spike Sorting Algorithm to Neuronal Signals Originated from Boron Doped Diamond Micro-Electrode Arrays	4
The effect of vibratory stimulation on the timed-up-and-go mobility test: a pilot study for sensory-related fall risk assessment	4
Puncture vine (Tribulus Terrestris L.) in control of health and reproduction	4
Are There Sex Differences in the Reaction of Undercarboxylated Osteocalcin to Hypoglycemia?	4
Ibuprofen does not Impair Skeletal Muscle Regeneration Upon Cardiotoxin-Induced Injury	4
Hemodynamic Adaptation of Heart Failure to Percutaneous Venoarterial Extracorporeal Circulatory Supports	4
Early Cardiac Injury in Acute Respiratory Distress Syndrome: Comparison of Two Experimental Models	4
Sex-Linked Differences in the Course of Thioacetamide-Induced Acute Liver Failure in Lewis Rats	4
Ovarian Steroid Hormone Secretion by Human Granulosa Cells After Supplementation of Sambucus nigra L. Extract	4
From a Passive Conduit to Highly Dynamic Organ. What are the Roles of Uterine Tube Epithelium in Reproduction?	4
Complex Sympathetic Regulation in Adolescent Mitral Valve Prolapse	4
SARS-CoV-2 Viral Load Assessment in Lung Transplantation	4
Fennel affects ovarian cell proliferation, apoptosis, and response to ghrelin	4
Rho-Kinase Inhibition Ameliorates Non-Alcoholic Fatty Liver Disease in Type 2 Diabetic Rats	4
PAR2: The Cornerstone of Pancreatic Diseases	4
Up-Regulation of CD163 Expression in Subpopulations of Blood Monocytes After Kidney Allograft Transplantation	4
Inhibition of L-NAME-Induced Hypertension by Combined Treatment With Apocynin and Catalase: The Role of Nox 4 Expression	4
Does Dihydromyricetin Impact on Alcohol Metabolism	4
The Role of Pulmonary Artery Wedge Pressure on the Incidence of Atrial Fibrillation and Atrial Tachycardias in Patients With Isolated Pre-capillary Pulmonary Hypertension	4
Elevated tenascin-C serum levels in patients with axial spondyloarthritis	4
Neonatal Hypoxic-Ischemic Brain Injury Leads to Sex-Specific Deficits in Rearing and Climbing in Adult Mice	4
Could the CCR5-Δ32 Mutation be Protective in SARS-CoV-2 Infection?	4
Baroreflex Sensitivity and Blood Pressure in Premature Infants – Dependence on Gestational Age, Postnatal Age and Sex	4
Tryptophan catabolism to serotonin and kynurenine in women undergoing in-vitro fertilization	4
Downregulation of long non-coding RNA AIRN promotes mitophagy in alcoholic fatty hepatocytes by promoting ubiquitination of mTOR	4
JAK2/STAT3 pathway mediates beneficial effects of pterostilbene on cardiac contractile and electrical function in the setting of myocardial reperfusion injury	4

Downregulation of miR-30c-5p Expression in Colorectal Cancer Tissue is Sex-Dependent	4
Efficacy of Surfactant Therapy of ARDS Induced by Hydrochloric Acid Aspiration Followed by Ventilator-Induced Lung Injury – an Animal Study	4