OOIR: Observatory of International Research

Papers

(The TQCC of Physiological Research is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
The Non-Invasive Transcranial Doppler for Hemodynamic Monitoring	42
Molecular Genetic Aspects of Sporadic Multiglandular Primary Hyperparathyroidism	41
MiR-18a Inhibits PI3K/AKT Signaling Pathway to Regulate PDGF BB-Induced Airway Smooth Muscle Cell Proliferation and Phenotypic Transformation	39
Gait Changes Following Robot-Assisted Gait Training in Children With Cerebral Palsy	37
Contralateral and Ipsilateral Arterial Vasculature of the Human Uterus: The Pilot Results of an Anatomical Study	32
Prediction of Akute Kidney Injury Development in Critically Ill Septic Patients Based on NGAL Determination	30
Pharmacological Inhibition of eIF2α Phosphorylation by Integrated Stress Response Inhibitor (ISRIB) Ameliorates Vascular Calcification in Rats	30
Assessment of the Cardiovascular Risk of High-Fat-High-Fructose Diet in Hereditary Hypertriacylglycerolemic Rats and Venlafaxine Effect	27
Synthetic Pyridoindole and Rutin Affect Upregulation of Endothelial Nitric Oxide Synthase and Heart Function in Rats Fed a High-Fat-Fructose Diet	27
Herbal Compounds in the Treatment of Pulmonary Silicosis	26
GPER-1 Rapid Regulation Influences p-Akt Expression to Resist Stress-Induced Injuries in a Sex-Specific Manner	26
Serum Glutathione and Malondialdehyde Levels as Predictors of Early Neurological Deficits and Short-Term Outcomes in Acute Cerebral Infarction	25
Steroid Conjugates and Their Physiological Role	21
Roles of Isometric Contraction Training in Promoting Neuroprotection and Angiogenesis After Stroke in Adult Rats	20
The Role of Cornichons in the Biogenesis and Functioning of Monovalent-Cation Transport Systems	20
Jaroslava Folbergrová, Dr.Sc. (1932 – 2024)	19
Comparative Analysis of Matrix Metalloproteinases by Zymography in Patients With Colorectal Carcinoma	19
Interactions of Renin-Angiotensin System and COVID-19: The Importance of Daily Rhythms in ACE2, ADAM17 and TMPRSS2 Expression	18
Can Prenatal Methamphetamine Exposure be Considered a Good Animal Model for ADHD?	18
Effects of Astaxanthin on Chronic Exercise Fatigue	18
Vitamin D Levels During Fracture Healing in Children	18
Electroacupuncture Stimulation Alleviates Inflammatory Pain in Male Rats by Suppressing Oxidative Stress	18
Our First Experience Implementing “Clinical Embryology and Reproductive Medicine” as a Curriculum Course of the Study Program General Medicine at the Faculty of Medicine in Bratislava, Slovakia	18
Methamphetamine, Neurotransmitters and Neurodevelopment	17
Cellular and Molecular Connections Between Bone Fracture Healing and Exosomes	17

Side Effects of Amino Acid Supplements	17
	17
Could the CCR5-Δ32 Mutation be Protective in SARS-CoV-2 Infection?	17
Pancreatic stellate cells - rising stars in pancreatic pathologies	16
The Relationship Between Hormonal Contraceptives, Level of Anxiety and Emotional Awareness: Pilot Project	16
Ellagic Acid Attenuates Muscle Atrophy in STZ-Induced Diabetic Mice	16
Effects of Hindlimb Suspension on the Development of Hip Bone Morphologies in Growing Rats	16
Distinct Cardiac Connexin-43 Expression in Hypertrophied and Atrophied Myocardium May Impact the Vulnerability of the Heart to Malignant Arrhythmias. A Pilot Study	15
Effect of Methylprednisolone on Experimental Brain Edema in Rats – Own Experience Reviewed	15
Pancreatic stellate cells - rising stars in pancreatic pathologies	15
The Temporal and Spatial Effects of Reconstructive Surgery on the Atrophy of Hindlimb Muscles in Anterior Cruciate Ligament Transected Rats	15
Mitochondrial Dysfunction in Kidney Cortex and Medulla of Subtotally Nephrectomized Rat	15
The impact of atrial fibrillation and atrial tachycardias on the hemodynamic status of patients with pulmonary hypertension	15
Can Buckwheat Affect Health and Female Reproductive Functions?	14
Capsaicin-Assessed Cough Reflex in Asthma Patients	14
Intraventricular Spring Expander Attenuates Cardiac Atrophy of the Failing Heart After Unloading Caused by Heterotopic Heart Transplantation: No Sex-Linked Differences	14
Influence of Blood Pressure and Heart Rate on PWV Measurement: Assessment Under Real-Time Blood Pressure Monitoring	13
Inflammation and Fibrosis Induced by Joint Remobilization, and Relevance to Progression of Arthrogenic Joint Contracture: A Narrative Review	13
Curcumin in vitro Neuroprotective Effects Are Mediated by p62/keap-1/Nrf2 and PI3K/AKT Signaling Pathway and Autophagy Inhibition	13
Dissociation Between the Epileptogenic Lesion and Primary Seizure Onset Zone in the Tetanus Toxin Model of Temporal Lobe Epilepsy	12
Direct Effects of Waterpipe Smoke Extract on Aortic Endothelial Cells: An In Vitro Study	12
Puncture vine (Tribulus Terrestris L.) in control of health and reproduction	12
Postprandial Triglyceride, Glucose and Insulin Levels 10 Years After Bariatric Surgery in Women With Severe Obesity – A Pilot Study: Part 1 – Laparoscopic Greater Curvature Plication	12
Response After Repeated Ketamine Injections in a Rat Model of Neuropathic Pain	12
Noninvasive arterial compliance estimation	11
Cytokine Cascade in Kawasaki Disease Versus Kawasaki-Like Syndrome	11
Mitochondrial Respiration of Human Platelets in Young Adult and Advanced Age – Seahorse or O2k?	11
Correlation Analysis of Serum 25-Hydroxyvitamin D Levels With Immune Function and Calcium-Phosphate Metabolism in Patients With Bronchial Asthma Treated With Combination Therapy	11
Sex differences in blood pressure, free radicals and plasma cholesterol fractions in Ren-2 transgenic rats of various ages	10
Altered Expression of ORAI and STIM Isoforms in Activated Human Cardiac Fibroblasts	10
First Application of Whole Genome Sequencing in Myelinated Retinal Nerve Fibers (MRNF)	10
Neurophysiological Assessment of H-Reflex Alterations in Compressive Radiculopathy	10
Endocrine Risk Factors for COVID-19 in Context of Aging	10
Role of 5-HT2 Receptors Family in the Allergy-Induced Increased Aorta Contractile Responses to 5-HT	10
History of Blood Pressure Measurement in Newborns and Infants	10
The Long-Term Effects of Growth Hormone Replacement on Bone Mineral Density and Trabecular Bone Score: Results of the 10-Year Prospective Follow-up	10
Serum Vitamin D Level in Overweight Individuals and Its Correlation With the Incidence of Non-alcoholic Fatty Liver Disease	10
Circadian Disruption as a Risk Factor for Development of Cardiovascular and Metabolic Disorders – From Animal Models to Human Population	10
Prediction of Vertebral Fractures by Trabecular Bone Score in Patients With Ankylosing Spondylitis	10
Sex Difference in Plasma Deoxyribonuclease Activity in Rats	9
Brain Fluid Channels for Metabolite Removal	9
The potential applications of artificial intelligence in drug discovery and development	9
Novel Predictors of Preeclampsia and Pregnancy Complications: the Impact of Type 1 Diabetes Mellitus on Maternal and Fetal Circulatory Levels	9
Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague	9
The Effect of Sulforaphane on Perinatal Hypoxic-Ischemic Brain Injury in Rats	9
Adaptive Induction of Nonshivering Thermogenesis in Muscle Rather Than Brown Fat Could Counteract Obesity	9
Anti-Müllerian Hormone Can Help With Predicting Ovarian Failure for Premenopausal Women Who Have Undergone Ablative Radioiodine Treatment for Thyroid Cancer	9
Waterpipe Smoke Inhalation Induces Lung Injury and Aortic Endothelial Dysfunction in Mice	9
Cardiorenal Syndromes and Their Role in Water and Sodium Homeostasis	9
ASIC1a Involves the Acid-Mediated Activation of Pancreatic Stellate Cells Associated With Autophagy Induction	9

Cholesterol efflux and macrophage polarization in human adipose tissue	8
Effect of Carvacrol on Diabetes-Induced Oxidative Stress, Fibrosis and Apoptosis in Testicular Tissues of Adult Rats	8
PAR2: The Cornerstone of Pancreatic Diseases	8
Altered Balance between Vasoconstrictor and Vasodilator Systems in Experimental Hypertension	8
The Effect of Bariatric-Metabolic Surgery on Selected Components of Metabolic Syndrome and Visceral Adipose Tissue – The Pilot Study	8
Ten Years of Our Translational Research in the Field of Veno-Arterial Extracorporeal Membrane Oxygenation	8
Experimental Lung Transplantation Related With HIF-1, VEGF, ROS. Assessment of HIF-1α, VEGF, and Reactive Oxygen Species After Competitive Blockade of Chetomin for Lung Transplantation in Rats	8
Unusual Functions of Insect Vitellogenins: Minireview	8
Rho-Kinase Inhibition Ameliorates Non-Alcoholic Fatty Liver Disease in Type 2 Diabetic Rats	8
Fluid shear stress-induced down-regulation of miR-146a-5p inhibits osteoblast apoptosis via targeting SMAD4	8
The Effect of Dietary Oat Consumption and Its Constituents on Fat Storage and Obesity	8
Immune Disorders and Sex Differences in Spontaneously Diabetic Torii Rats, Type 2 Diabetic Model	8
Gut Hormone Levels During Mixed Liquid Meal Test in Short Bowel Syndrome, the Possible Influence on the Intestine Adaptation	7
Chronic Venous Disease and Its Intersections With Diabetes Mellitus	7
Is there a Need to Change the Basic Principles of Histology? Educational, Functional and Embryological Perspective	7
Iodine Intake and Iodine Status in the Czech Republic – Past, Present, Future	7
Nutrition and Bone Marrow Adiposity in Relation to Bone Health	7
Colored Light Exposure Ensues Chronotype-Based Responses: Evidence From QEEG Analysis	7
Inhibition of Extracellular Signal-Regulated Kinase Downregulates Endoplasmic Reticulum Stress-Induced Apoptosis and Decreases Brain Injury in a Cardiac Arrest Rat Model	7
Correlation Between Nongenomic Action of C19-Steroids and COVID-19 Severity	7
NADPH oxidase 4 contributes to oxidative stress in a mouse model of myocardial infarction	7
Eicosapentaenoic Acid Alleviates Inflammatory Response and Insulin Resistance in Pregnant Mice With Gestational Diabetes Mellitus	7
Effects of Acute Pump Speed Changes on Cerebral Hemodynamics in Patients With an Implantable Continuous-Flow Left Ventricular Assist Devices	7
Steroidogenic Enzyme Gene Expression and Testosterone Production are Developmentally Modulated by Bone Morphogenetic Protein Receptor-1B in Mouse Testis	7
From a Passive Conduit to Highly Dynamic Organ. What are the Roles of Uterine Tube Epithelium in Reproduction?	7
Baicalin Ameliorates Cartilage Injury in Rats With Osteoarthritis via Modulating miR-766-3p/AIFM1 Axis	7
Short-Term Arterial Compliance Changes in the Context of Systolic Blood Pressure Influence	7
The Role of L-Cysteine/H2S Pathway in CaSRs-Mediated Relaxations in Mouse Bladder Tissue	7
Fibroblast Growth Factor 23 and Klotho Are Associated With Trabecular Bone Score but Not Bone Mineral Density in the Early Stages of Chronic Kidney Disease: Results of the Cross-Sectional Study	7
Aspalathin Alleviates Skeletal Muscle Insulin Resistance and Mitochondrial Dysfunction	6
Bruton’s Tyrosine Kinase: A Potential Novel Target for Neurological Disorders	6
Association of Polymorphisms in Endothelin-1 and Endothelin Receptor A Genes With Vasovagal Syncope	6
Analysis of Gene Expression Profiles Regulating Phenotypic Transformation of Vascular Smooth Muscle Cells by Endothelial Cell-Derived Exosomes	6
Ca2+ Depletion in the ER Causes Store-Operated Ca2+ Entry via the TRPC6 Channel in Mouse Brown Adipocytes	6
Cardiovascular Changes During Phototherapy in Newborns	6
Decellularization techniques of human foreskin for tissue engineering application	6
Modern Perspective of Lactate Metabolism	6
Is Apelin a new biomarker in patients with polycystic ovary syndrome?	6
Metabolic Syndrome in Hypertriglyceridemic Rats: Effects of Antioxidants	6
Postprandial Triglyceride, Glucose and Insulin Levels 10 Years After Bariatric Surgery in Women With Severe Obesity – A Pilot Study: Part 2 – Biliopancreatic Diversion	6
The Role of Pulmonary Artery Wedge Pressure on the Incidence of Atrial Fibrillation and Atrial Tachycardias in Patients With Isolated Pre-capillary Pulmonary Hypertension	6
Altered Plasma Butyrylcholinesterase Activity in Streptozotocin-Induced Diabetic Hypertensive Rats Does Not Reflect Impaired Liver Function	6
Berberine Exerts Neuroprotective Effects in Alzheimer’s Disease by Switching Microglia M1/M2 Polarization Through PI3K-AKT Signaling	6
Comprehensive Genomic Profiling in Predictive Testing of Cancer	6
Circulating Exosomal miRNAs as a Promising Diagnostic Biomarker in Cancer	6
Protection of Toll-Like Receptor 9 Against Lipopolysaccharide-Induced Inflammation and Oxidative Stress of Pulmonary Epithelial Cells via MyD88-Mediated Pathways	6
Treatment With Cholecalciferol Leads to Increase Of Selected Semen Parameters in Young Infertile Males: Results of a 6-month Interventional Study	5
miR-491-5p Inhibits Emilin 1 to Promote Fibroblasts Proliferation and Fibrosis in Gluteal Muscle Contracture via TGF-β1/Smad2 Pathway	5
Interplay Between Astroglial Endocannabinoid System and the Cognitive Dysfunction in Alzheimer's Disease	5
The Severity of Muscle Performance Deterioration in Sarcopenia Correlates With Circulating Muscle Tissue-Specific miRNAs	5
Research on Experimental Hypertension in Prague (1966-2009)	5
Dihydromyricetin Inhibits Ferroptosis to Attenuate Cisplatin-Induced Muscle Atrophy	5
Mechanisms Controlling the Behavior of Vascular Smooth Muscle Cells in Hypoxic Pulmonary Hypertension	5
Endothelial-Mesenchymal Transition or Functional Tissue Regeneration – Two Outcomes of Heart Remodeling	5
Effects of total intravenous anesthesia with etomidate and propofol on postoperative cognitive dysfunction	5
Parvalbumin - Positive Neurons in the Neocortex: A Review	5
The Expression Level of Inflammation-Related Genes in Patients With Bone Nonunion and the Effect of BMP-2 Infected Mesenchymal Stem Cells Combined With nHA/PA66 on the Inflammation Level of Femoral Bo	5
Cerebral Perfusion Pressure and Behavior Monitoring in Freely Moving Rats	5
Role of Carvedilol in Inhibiting the Proliferation and Migration of Vascular Smooth Muscle Cells by Upregulating microRNA-145 Expression	5
Differential Mitochondrial Adaptation of the Slow and Fast Skeletal Muscles by Endurance Running Exercise in Streptozotocin-Induced Diabetic Mice	5
Cadmium-Induced Hepatotoxicity in Mice – Prophylactic Supplementation of Quercetin Exerts Hepatoprotective Effect by Modulating PI3K/Akt/NF-κB Signaling Pathway	5
Impairment of Endogenous H2S Pathway due to Aging and Endothelium Denudation in Mouse Isolated Thoracic Aorta	5
Sixty Years of Heart Research in the Institute of Physiology of the Czech Academy of Sciences	5
Ginsenoside-MC1 Alleviates Stroke by Modulating AMPK/SIRT1 Pathway in a Rat Model	5
Hydrolat of Helichrysum Italicum promotes tissue regeneration during wound healing	5
Progesterone Inhibitory Role on Gastrointestinal Motility	5
Androgens in SARS-CoV-2 Coronavirus Infections	5
Biomarkers of the Physical Function Mobility Domains Among Patients Hospitalized in Internal Medicine	5
Clinical Efficacy of Blood Ultrafiltration Therapy in Patients with Acute Decompensated Chronic Heart Failure	5
Are Oligodendrocytes the Culprits or Victims in Alzheimer's Disease	5
Effect of Laparoscopic Sleeve Gastrectomy on Serum Adipokine Levels	5
Podophyllotoxin Alleviates DSS-Induced Ulcerative Colitis via PI3K/AKT Pathway Activation	5
The potential applications of artificial intelligence in drug discovery and development	5