Biotechnology and Applied Biochemistry

Article	Citations
Caspase‐3: Structure, function, and biotechnological aspects	143
The interplay of ROS and the PI3K/Akt pathway in autophagy regulation	138
SELEX: Critical factors and optimization strategies for successful aptamer selection	76
An overview on the conversion of glycerol to value‐added industrial products via chemical and biochemical routes	72
Enzymes for pharmaceutical and therapeutic applications	56
Glucose oxidase: Applications, sources, and recombinant production	53
Laccase: Various types and applications	48
Enzyme engineering and its industrial applications	46
Biochemical features of dye‐decolorizing peroxidases: Current impact on lignin degradation	40
Microbial lipase production: A deep insight into the recent advances of lipase production and purification techniques	40
Biosensors based on aptamer‐conjugated gold nanoparticles: A review	38
β‐Galactosidase: From its source and applications to its recombinant form	35
Silver nanoparticle in biosensor and bioimaging: Clinical perspectives	33
The antibacterial mechanism of perilla rosmarinic acid	32
Novel surface plasmon resonance biosensor that uses full‐length Det7 phage tail protein for rapid and selective detection of Salmonella enterica serovar Typhimurium	31
CBD activation of TRPV1 induces oxidative signaling and subsequent ER stress in breast cancer cell lines	29
Light‐driven catalysis with engineered enzymes and biomimetic systems	28
Future developments in biosensors for field‐ready SARS‐CoV‐2 virus diagnostics	28
Mimochrome, a metalloporphyrin‐based catalytic Swiss knife†	26
Antisense Oligonucleotide (AS‐ODN) Technology: Principle, Mechanism and Challenges	25
Synthesis and characterization of thermosensitive hydrogel based on quaternized chitosan for intranasal delivery of insulin	25
The antidiabetic potential of endophytic fungi: Future prospects as therapeutic agents	23
Application of natural products for inducing ferroptosis in tumor cells	22
Harmful effects of high amounts of glucose on the immune system: An updated review	21
Ophthalmic drugs: in vitro paraoxonase 1 inhibition and molecular docking studies	21

Vitamin E at a high dose as an anti‐ferroptosis drug and not just a supplement for COVID‐19 treatment	20
An electrochemical aptasensor for detection of prostate‐specific antigen using reduced graphene gold nanocomposite and Cu/carbon quantum dots	20
An electrochemical aptasensor for detection of prostate‐specific antigen‐based on carbon quantum dots‐gold nanoparticles	20
Versatility of subtilisin: A review on structure, characteristics, and applications	20
Lignin valorization using biological approach	19
Highly sensitive and selective acute myocardial infarction detection using aptamer‐tethered MoS 2 nanoflower and screen‐printed electrodes	19
CRISPR/Cas9‐based genome engineering: A new breakthrough in the genetic manipulation of filamentous fungi	19
Combining technology with liquid‐formulated lipases for in‐spec biodiesel production	19
Mussel‐inspired polydopamine induced the osteoinductivity to ice‐templating PLGA–gelatin matrix for bone tissue engineering application	19
Hyaluronic acid–graphene quantum dot nanocomposite: Potential target drug delivery and cancer cell imaging	18
Futuristic avenues of metabolic engineering techniques in bioremediation	18
A brief overview on the application and sources of α‐amylase and expression hosts properties in order to production of recombinant α‐amylase	18
Production of myo‐inositol: Recent advance and prospective	18
Ellagic acid as a potent anticancer drug: A comprehensive review on in vitro, in vivo, in silico, and drug delivery studies	17
Lactobacillus bulgaricus and Lactobacillus plantarum improve diabetic wound healing through modulating inflammatory factors	17
Development of novel strategies for higher fermentative biohydrogen recovery along with novel metabolites from organic wastes: The present state of the art	17
Trends in lipase engineering for enhanced biocatalysis	17
Enzymatic transesterification of coconut oil by using immobilized lipase on biochar: An experimental and molecular docking study	17
Bacterial pigments: A colorful palette reservoir for biotechnological applications	16
Upregulation of TRPM8 can promote the colon cancer liver metastasis through mediating Akt/GSK‐3 signal pathway	16
Rapid and label‐free electrochemical DNA biosensor based on a facile one‐step electrochemical synthesis of rGO–PPy–(L‐Cys)–AuNPs nanocomposite for the HTLV‐1 oligonucleotide detection	16
The effect of brimonidine and proparacaine on metabolic enzymes: Glucose‐6‐phosphate dehydrogenase, 6‐phosphogluconate dehydrogenase, and glutathione reductase	16
Relationship between Sphk1/S1P and microRNAs in human cancers	15
In situ product recovery techniques aiming to obtain biotechnological products: A glance to current knowledge	15
Application of lipase immobilized on a hydrophobic support for the synthesis of aromatic esters	15
Structural and functional diversity of asparaginases: Overview and recommendations for a revised nomenclature	15
Pretreatment of rice straw with recycled ionic liquids by phase‐separation process for low‐cost biorefinery	15
Role of neddylation in neurological development and diseases	15
Repurposing of quinoline alkaloids identifies their ability to enhance doxorubicin‐induced sub‐G0/G1 phase cell cycle arrest and apoptosis in cervical and hepatocellular carcinoma cells	15
Purification and properties of a laccase from the mushroom Agaricus sinodeliciosus	14
Aptamer–17β‐estradiol–antibody sandwich ELISA for determination of gynecological endocrine function	13
Green synthesis of silver and gold nanoparticles using Crataegus oxyacantha extract and their urease inhibitory activities	13
A stable biosensor for organophosphorus pesticide detection based on chitosan modified graphene	13
Biological properties and structural characterization of a novel rhamnolipid like‐biosurfactants produced by Lactobacillus casei subsp. casei TM1B	13
Cloning, characterization, and enzymatic identification of a new tryptophan decarboxylase from Ophiorrhiza pumila	13
Phytosynthesis of CuONPs via Laurus nobilis: Determination of antioxidant content, antibacterial activity, and dye decolorization potential	13
Nuciferine from Nelumbo nucifera Gaertn. attenuates isoproterenol‐induced myocardial infarction in Wistar rats	13
Pain pathways and potential new targets for pain relief	12
Advances in biochemistry and the biotechnological production of taxifolin and its derivatives	12
In vitro evaluation of copper sulfide nanoparticles decorated with folic acid/chitosan as a novel pH‐sensitive nanocarrier for the efficient controlled targeted delivery of cytarabine as an anticancer	12
Green synthesis and characterization of silver nanoparticles using Pteris vittata extract and their therapeutic activities	12
A comprehensive review on anticancer mechanism of bazedoxifene	12
Production of a fermented solid containing lipases from Penicillium roqueforti ATCC 10110 and its direct employment in organic medium in ethyl oleate synthesis	12
CircSEC24A promotes IL‐1β‐induced apoptosis and inflammation in chondrocytes by regulating miR‐142‐5p/SOX5 axis	12
Fermentation optimization of surfactin production of Bacillus amyloliquefaciens HM618	12
β‐Carotene—production methods, biosynthesis from Phaffia rhodozyma, factors affecting its production during fermentation, pharmacological properties: A review	12
Thermostable trypsin‐like protease by Penicillium roqueforti secreted in cocoa shell fermentation: Production optimization, characterization, and application in milk clotting	11
Monascin and ankaflavin—Biosynthesis from Monascus purpureus, production methods, pharmacological properties: A review	11
Enhancement and mechanisms of MC3T3‐E1 osteoblast‐like cell adhesion to albumin through calcium exposure	11
Ethylene glycol and glycolic acid production by wild‐type Escherichia coli	11

Technofunctional quality assessment of soymilk fermented with Lactobacillus acidophilus and Lactobacillus casei	11
Metabolic engineering of Corynebacterium glutamicum WM001 to improve l‐isoleucine production	11
Development of rapid gold nanoparticles based lateral flow assays for simultaneous detection of Shigella and Salmonella genera	11
Platelet‐rich plasma‐hyaluronic acid/chondrotin sulfate/carboxymethyl chitosan hydrogel for cartilage regeneration	11
The effects of Lycium barbarum water extract and fish collagen on milk proteolysis and in vitro angiotensin I‐converting enzyme inhibitory activity of yogurt	11
Microbial nitroreductases: A versatile tool for biomedical and environmental applications	11
Novel enzyme‐based electrochemical and colorimetric biosensors for tetracycline monitoring in milk	11
Urea biosensors: A comprehensive review	11
Betaine‐assisted recombinase polymerase assay for rapid hepatitis B virus detection	11
Multifaceted antiviral therapeutic potential of dietary flavonoids: Emerging trends and future perspectives	10
Icaritin and icariin reduce p‐Tau levels in a cell model of Alzheimer's disease by downregulating glycogen synthase kinase 3β	10
microRNAs: Small molecules with a large impact on colorectal cancer	10
Influence of calcium and magnesium elimination on plant biomass and secondary metabolites of Stevia rebaudiana Bertoni	10
Organic solvent stability and long‐term storage of myoglobin‐based carbene transfer biocatalysts	10
Vitamin K: A novel cancer chemosensitizer	10
Esterases as emerging biocatalysts: Mechanistic insights, genomic and metagenomic, immobilization, and biotechnological applications	10
In vitro and in silico anticancer evaluation of a medicinal mushroom, Ganoderma neo‐japonicum Imazeki, against human colonic carcinoma cells	10
Downregulation of SDCBP inhibits cell proliferation and induces apoptosis by regulating PI3K/AKT/mTOR pathway in gastric carcinoma	10
Purification, characterization, and antifungal activity of Bacillus cereus strain NK91 chitinase from rhizospheric soil samples of Himachal Pradesh, India	10
Unlocking the biosynthetic potential of Penicillium roqueforti for hyperproduction of the immunosuppressant mycophenolic acid: Gamma radiation mutagenesis and response surface optimization of f	10
Ghrelin ameliorates chronic obstructive pulmonary disease–associated infllammation and autophagy	10
Nanophytosomes of hesperidin and of hesperetin: Preparation, characterization, and in vivo evaluation	9
Biochanin‐A has antidiabetic, antihyperlipidemic, antioxidant, and protective effects on diabetic nephropathy via suppression of TGF‐β1 and PAR‐2 genes expression in kidney tissues of STZ‐induced diab	9
Evaluation of antityrosinase activity and mechanism, antioxidation, and UV filter properties of theaflavin	9
Composite of medium‐chain‐length polyhydroxyalkanoates‐co‐methyl acrylate and carbon nanotubes as innovative electrodes modifier in microbial fuel cell	9
High‐level production of d ‐pantothenic acid from glucose by fed‐batch cultivation of Escherichia coli	9
Enzymatic hydrolysis of lignocellulosic biomass using native cellulase produced by Aspergillus niger ITV02 under liquid state fermentation	9
Screening and molecular characterization of new thermo‐ and ethanol‐tolerant Acetobacter malorum strains isolated from two biomes Moroccan cactus fruits	9
USP47 promotes apoptosis in rat myocardial cells after ischemia/reperfusion injury via NF‐κB activation	9
3D‐printed scaffold composites for the stimuli‐induced local delivery of bioactive adjuncts	9
Parametric optimization and kinetic study of l‐lactic acid production by homologous batch fermentation of Lactobacillus pentosus cells	9
EGF‐functionalized lipid–polymer hybrid nanoparticles of 5‐fluorouracil and sulforaphane with enhanced bioavailability and anticancer activity against colon carcinoma	9
Investigation of inhibition effect of butanol and water extracts of Matricaria chamomilla L. on angiotensin‐converting enzyme purified from human plasma	9
Novel green synthesis and characterization of a chemotherapeutic supplement by silver nanoparticles containing Berberis thunbergii leaf for the treatment of human pancreatic cancer	9
Purification of the phytase enzyme from Lactobacillus plantarum: The effect on pansy growth and macro–micro element content	9
Some indazoles as alternative inhibitors for potato polyphenol oxidase	9
Unveiling the dermatological potential of marine fungal species components: Antioxidant and inhibitory capacities over tyrosinase	9
Development and optimization of N‐acetylneuraminic acid biosensors in Bacillus subtilis	9
Thymoquinone inhibits IL‐7‐induced tumor progression and metastatic invasion in prostate cancer cells by attenuating matrix metalloproteinase activity and Akt/NF‐κB signaling	9
Synthesis, physicochemical characterization, and in vitro evaluation of biodegradable PLGA nanoparticles entrapped to folic acid for targeted delivery of kaempferitrin	9
Prodigiosin production from Serratia marcescens strain CSK and their antioxidant, antibacterial, cytotoxic effect and in silico study of caspase‐3 apoptotic protein	8
The response of yeast vacuolar proteins: A novel rapid tool for Salmonella sp. screening	8
Upregulation of the long noncoding RNAs DSCAM‐AS1 and MANCR is a potential diagnostic marker for breast carcinoma	8
Chemoselective N−H insertion catalyzed by a de novo carbene transferase	8
Evaluation of anti‐EGFR potential of quinazoline derivatives using molecular docking: An in silico approach	8
Ethical and regulatory issues in human gene editing: Chinese perspective	8
Isolation of cyanide‐degrading bacteria and molecular characterization of its cyanide‐degrading nitrilase	8
Label‐free molecular detection of antibiotic susceptibility for Mycobacterium smegmatis using a low cost electrode format	8
Improving propionic acid production from a hemicellulosic hydrolysate of sorghum bagasse by means of cell immobilization and sequential batch operation	8
Progress in gene therapy treatments for prostate cancer	8
In silico prediction of T‐cell and B‐cell epitopes of human papillomavirus type 16 L1 protein	8
Biomarkers of minimal residual disease in rituximab‐treated patients with mixed cryoglobulinemia	8
Liposomes: Ideal drug delivery systems in breast cancer	8
Effect of phenolic compounds from the leaves of Psidium guajava on the activity of three metabolism‐related enzymes	8
Clickable artificial heme‐peroxidases for the development of functional nanomaterials	8
Usage of peptidases by SARS‐CoV‐2 and several human coronaviruses as receptors: A mysterious story	8
Downregulation of gap junctional intercellular communication and connexin 43 expression by bisphenol A in human granulosa cells	8
Conjugation of micro/nanocurcumin particles to ZnO nanoparticles changes the surface charge and hydrodynamic size thereby enhancing its antibacterial activity against Escherichia coli and St	8
Preparation of PEI‐modified nanoparticles by dopamine self‐polymerization for efficient DNA delivery	8
Isolation and characterization of a novel nanobody for detection of GRP78 expressing cancer cells	8
Immunomodulatory effect of Linalool (Lin) against CCl4‐induced hepatotoxicity and oxidative damage in rats	8
Preparation and antibacterial effect of chitooligosaccharides monomers with different polymerization degrees from crab shell chitosan by enzymatic hydrolysis	8
Successful use of Nicotiana tabacum hairy roots for the recombinant production of Cecropin A peptide	8
Biosensor as an alternative diagnostic method for rabies virus detection: A literature review	8
Preparation and in vitro characterization of histidine trimethyl chitosan conjugated nanocomplex incorporated into injectable thermosensitive hydrogels for localized gene delivery	7
Colorimetric identification of miRNA‐195 sequence for diagnosing osteosarcoma	7
Surface engineered iron oxide nanoparticles as efficient materials for antibiofilm application	7
Artificial iron hydrogenase made by covalent grafting of Knölker's complex into xylanase: Application in asymmetric hydrogenation of an aryl ketone in water	7
Antibacterial activity of curcumin and its essential nanoformulations against some clinically important bacterial pathogens: A comprehensive review	7
Penicillium fellutanum lipase as a green and ecofriendly biocatalyst for depolymerization of poly (ɛ‐caprolactone): Biochemical, kinetic, and thermodynamic investigations	7
The effects of high‐fat diet and metformin on urinary metabolites in diabetes and prediabetes rat models	7
Overexpression of blue light receptor AaCRY1 improves artemisinin content in Artemisia annua L.	7
A thermophilic chitinase 1602 from the marine bacterium Microbulbifer sp. BN3 and its high‐level expression in Pichia pastoris	7
Biotransformation and chiral resolution of d,l‐alanine into pyruvate and d‐alanine with a whole‐cell biocatalyst expressing l‐amino acid deaminase	7
Protein corona: Dr. Jekyll and Mr. Hyde of nanomedicine	7
Effective‐by‐method for the preparation of folic acid‐coated TiO2 nanoparticles with high targeting potential for apoptosis induction against bladder cancer cells (T24)	7
β‐Glucosidase produced by Moniliophthora perniciosa: Characterization and application in the hydrolysis of sugarcane bagasse	7
Microfluidic‐assisted fabrication of reverse micelle/PLGA hybrid microspheres for sustained vascular endothelial growth factor delivery	7
Genome mining and functional analysis of cytochrome P450 genes involved in insecticide resistance in Leucinodes orbonalis (Lepidoptera: Crambidae)	7
Genetic engineering of the branched‐chain fatty acid biosynthesis pathway to enhance surfactin production from Bacillus subtilis	7

UCH‐L3 promotes non‐small cell lung cancer proliferation via accelerating cell cycle and inhibiting cell apoptosis	7
Different experimental approaches for Fourier‐transform infrared spectroscopy applications in biology and biotechnology: A selected choice of representative results	7
An insight into the role of telmisartan as PPAR‐γ/α dual activator in the management of nonalcoholic fatty liver disease	7
Correspondence: Importance of the validated serum biochemistry and hemogram parameters for rapid diagnosis and to prevent false negative results during COVID‐19 pandemic	7
CircRNA circ_0006892 regulates miR‐24/PHLPP2 axis to mitigate cigarette smoke extract‐induced bronchial epithelial cell injury	7
Phytocompounds curcumin, quercetin, indole‐3‐carbinol, and resveratrol modulate lactate–pyruvate level along with cytotoxic activity in HeLa cervical cancer cells	7
A novel approach to production of Chlorella protothecoides oil‐loaded nanoparticles via electrospraying method: Modeling of critical parameters for particle sizing	7
The multipotent thidiazuron: A mechanistic overview of its roles in callogenesis and other plant cultures in vitro	7
The genus Simplicillium and Emericellopsis: A review of phytochemistry and pharmacology	7
Chromosomal editing of Corynebacterium glutamicum ATCC 13032 to produce gamma‐aminobutyric acid	7
Zerumbone‐induced reactive oxygen species‐mediated oxidative stress re‐sensitizes breast cancer cells to paclitaxel	6
Vanillic acid as phospholipase A2 and proteases inhibitor: In vitro and computational analyses	6
Melamine contamination and associated health risks: Gut microbiota does make a difference	6
Nanotechnology‐driven advances in the treatment of diabetic wounds	6
Constitutive secretory expression and characterization of nitrilase from Alcaligenes faecalis in Pichia pastoris for production of R‐mandelic acid	6
Emergence of nanomaterials as potential immobilization supports for whole cell biocatalysts and cell toxicity effects	6
Construction and characterization of novel bifunctional fusion proteins composed of alcohol dehydrogenase and NADH oxidase with efficient oxidized cofactor regeneration	6
The flavonoid 3′‐hydroxylase gene from the Antarctic moss Pohlia nutans is involved in regulating oxidative and salt stress tolerance	6
Simultaneous detection of fungal (1,3)‐β‐d‐glucan and procalcitonin using a dual‐label time‐resolved fluorescence immunoassay	6
Design and in vitro antibiofilm activity of propolis diffusion‐controlled biopolymers	6
Overexpression, overproduction, purification, and characterization of rhGH in Escherichia coli	6
Design of a Fe4S4 cluster into the core of a de novo four‐helix bundle	6
Phlorotannins as HIV Vpu inhibitors, an in silico virtual screening study of marine natural products	6
Chronic stress and Alzheimer's disease	6
Preparation and characterization of biogenic silver nanoparticles using Strobilanthes cordifolia (Vahl) J.R.I. Wood leaves and its biological applications	6
Proteomic exploration of soft and hard biocorona onto PEGylated multiwalled carbon nanotubes	6
De novo assembly of Auricularia polytricha transcriptome and discovery of genes involved in the degradation of lignocellulose	6
Conducting polymer‐based electrochemical biosensor for the detection of acetylthiocholine and pesticide via acetylcholinesterase	6
Effect of nickel, cobalt, and iron on methanogenesis from methanol and cometabolic conversion of 1,2‐dichloroethene by Methanosarcina barkeri	6
Genome engineering and synthetic biology for biofuels: A bibliometric analysis	6
Sensitive determination of NT‐proBNP for diagnosing abdominal aortic aneurysms incidence on interdigitated electrode sensor	6
Accelerated wound closure: Systematic evaluation of cellulose acetate effects on biologically active molecules release from amniotic fluid stem cells	6
Analysis of carotenoid profile changes and carotenogenic genes transcript levels in Rhodosporidium toruloides mutants from an optimized Agrobacterium tumefaciens‐mediated transformation	6
Dilute acid pretreatment for enhancing the enzymatic saccharification of agroresidues using a Botrytis ricini endoglucanase	6
Enzymatic synthesis of structured lipids from grape seed (Vitis vinifera L.) oil in associated packed bed reactors	6
α‐Amylase and cellulase production by novel halotolerant Bacillus sp.PM06 isolated from sugarcane pressmud	6
Synthesized nanoliposome‐encapsulated kaempferol attenuates liver health parameters and gene expression in mice challenged by cadmium‐induced toxicity	6
Inducible expression of human papillomavirus‐16 L1 capsomeres in the plastomes of Nicotiana tabacum: Transplastomic plants develop normal flowers and pollen	6
Formulation of a pH‐sensitive cancer cell‐targeted gene delivery system based on folate–chitosan conjugated nanoparticles	6
Synthesis of substituted 2H‐chromenes catalyzed by lipase immobilized on magnetic multiwalled carbon nanotubes	6
Exploration of potential inhibitors for SARS‐CoV‐2 Mpro considering its mutants via structure‐based drug design, molecular docking, MD simulations, MM/PBSA, and DFT calculations	6
Palbociclib negatively regulates fatty acid synthesis due to upregulation of AMPKα and miR‐33a levels to increase apoptosis in Panc‐1 and MiaPaCa‐2 cells	6
Gene expression studies of Saccharum spontaneum, a wild relative of sugarcane in response to salinity stress	6
Determination of cardiac disease biomarker by plasmonic sandwich ELISA	6
A comprehensive review of COVID‐19 in India: A frequent catch of the information	6
Spectroscopic studies and molecular docking on the interaction of delphinidin‐3‐O‐galactoside with tyrosinase	6
Study of tyrosine and dopa enantiomers as tyrosinase substrates initiatingl‐ andd‐melanogenesis pathways	6
Forty years of study on the thermostable β‐glycosidase from S. solfataricus: Production, biochemical characterization and biotechnological applications	6
Proteomic analysis of human follicular fluid from polycystic ovary syndrome patients	6
The effects of exogenous cerium on photosystem II as probed by in vivo chlorophyll fluorescence and lipid production ofScenedesmus obliquusXJ002	6