Metabolic Brain Disease

Article	Citations
Emerging role of non‐coding RNA in health and disease	81
Towards a new model and classification of mood disorders based on risk resilience, neuro-affective toxicity, staging, and phenome features using the nomothetic network psychiatry approach	66
Neuroinflammation in neurological disorders: pharmacotherapeutic targets from bench to bedside	65
Role of metals in Alzheimer’s disease	63
Crossing the blood-brain barrier with AAV vectors	45
Cellular and molecular pathophysiology in the progression of Parkinson’s disease	40
Neurovascular dysfunction and vascular amyloid accumulation as early events in Alzheimer's disease	40
PTZ kindling model for epileptogenesis, refractory epilepsy, and associated comorbidities: relevance and reliability	40
β-Asarone improves learning and memory in Aβ1-42-induced Alzheimer’s disease rats by regulating PINK1-Parkin-mediated mitophagy	37
Clinical features, pathogenesis, and management of stroke-like episodes due to MELAS	37
Neuroprotective potential of Malva neglecta is mediated via down-regulation of cholinesterase and modulation of oxidative stress markers	34
Guggulsterone ameliorates ethidium bromide-induced experimental model of multiple sclerosis via restoration of behavioral, molecular, neurochemical and morphological alterations in rat brain	33
Cannabidiol induces antidepressant and anxiolytic‐like effects in experimental type-1 diabetic animals by multiple sites of action	29
Amelioration of oxidative stress and neuroinflammation in lipopolysaccharide-induced memory impairment using Rosmarinic acid in mice	29
Cognitive impairment caused by hypoxia: from clinical evidences to molecular mechanisms	27
Physical exercise protocols in animal models of Alzheimer’s disease: a systematic review	27
A novel antagonist of TRPM2 and TRPV4 channels: Carvacrol	27
Neurodegenerative Disorders of Alzheimer, Parkinsonism, Amyotrophic Lateral Sclerosis and Multiple Sclerosis: An Early Diagnostic Approach for Precision Treatment	25
Insulin resistance: a connecting link between Alzheimer’s disease and metabolic disorder	25
Methods used for the measurement of blood-brain barrier integrity	25
Neuromodulatory effects of green coffee bean extract against brain damage in male albino rats with experimentally induced diabetes	25
The role of syringic acid as a neuroprotective agent for neurodegenerative disorders and future expectations	25
Circ_0006768 upregulation attenuates oxygen–glucose deprivation/reoxygenation-induced human brain microvascular endothelial cell injuries by upregulating VEZF1 via miR-222-3p inhibition	24
Metabolic disorder in Alzheimer’s disease	24
Profiles of urine and blood metabolomics in autism spectrum disorders	24

Hesperetin ameliorates diabetes-associated anxiety and depression-like behaviors in rats via activating Nrf2/ARE pathway	24
Reactive gliosis in Alzheimer’s disease: a crucial role for cognitive impairment and memory loss	23
Selenium prevents interferon-gamma induced activation of TRPM2 channel and inhibits inflammation, mitochondrial oxidative stress, and apoptosis in microglia	22
Physical exercise prevents amyloid β1−40-induced disturbances in NLRP3 inflammasome pathway in the hippocampus of mice	22
Neuroprotective effects of 18β-glycyrrhetinic acid against bisphenol A-induced neurotoxicity in rats: involvement of neuronal apoptosis, endoplasmic reticulum stress and JAK1/STAT1 signaling pathway	22
Calorie restriction promotes remyelination in a Cuprizone-Induced demyelination mouse model of multiple sclerosis	22
Hesperidin protects against behavioral alterations and loss of dopaminergic neurons in 6-OHDA-lesioned mice: the role of mitochondrial dysfunction and apoptosis	22
Bone marrow mesenchymal stem cell-derived exosomes carrying long noncoding RNA ZFAS1 alleviate oxidative stress and inflammation in ischemic stroke by inhibiting microRNA-15a-5p	22
Capsaicin induces redox imbalance and ferroptosis through ACSL4/GPx4 signaling pathways in U87-MG and U251 glioblastoma cells	22
Treatment trials in Niemann-Pick type C disease	21
Protective mechanism of Syringic acid in an experimental model of Parkinson’s disease	21
MiRNA-34c-5p protects against cerebral ischemia/reperfusion injury: involvement of anti-apoptotic and anti-inflammatory activities	21
MALDI imaging mass spectrometry: an emerging tool in neurology	21
RhoA/ROCK signaling pathway and astrocytes in ischemic stroke	20
Targeting inflammation: a potential approach for the treatment of depression	20
Neuroprotective effects of garlic extract on dopaminergic neurons of substantia nigra in a rat model of Parkinson’s disease: motor and non‐motor outcomes	20
Acetyl-L-carnitine confers neuroprotection against lipopolysaccharide (LPS) -induced neuroinflammation by targeting TLR4/NFκB, autophagy, inflammation and oxidative stress	20
LncRNA SNHG3 promotes autophagy-induced neuronal cell apoptosis by acting as a ceRNA for miR-485 to up-regulate ATG7 expression	20
Agomelatine confers neuroprotection against cisplatin-induced hippocampal neurotoxicity	19
Taurine, an essential β-amino acid insulates against ketamine-induced experimental psychosis by enhancement of cholinergic neurotransmission, inhibition of oxidative/nitrergic imbalances, and suppress	19
Pathogenesis and promising therapeutics of Alzheimer disease through eIF2α pathway and correspondent kinases	19
The neuroprotective effect of betanin in trimethyltin-induced neurodegeneration in mice	19
Icariin enhance mild hypothermia-induced neuroprotection via inhibiting the activation of NF-κB in experimental ischemic stroke	19
A comprehensive review on the role of chemokines in the pathogenesis of multiple sclerosis	18
Improvement of cerebral ischemia/reperfusion injury by daucosterol palmitate-induced neuronal apoptosis inhibition via PI3K/Akt/mTOR signaling pathway	18
Crosstalk between Sirtuins and Nrf2: SIRT1 activators as emerging treatment for diabetic neuropathy	18
Morin hydrate attenuates chronic stress-induced memory impairment and degeneration of hippocampal subfields in mice: The role of oxidative, nitrergic and neuroinflammatory pathways	18
Pain-relieving effects of Lawsonia inermis on neuropathic pain induced by chronic constriction injury	18
Exposure to a high dose of amoxicillin causes behavioral changes and oxidative stress in young zebrafish	18
Animal models of gestational diabetes: characteristics and consequences to the brain and behavior of the offspring	18
Neuroprotective effects of liraglutide against inflammation through the AMPK/NF-κB pathway in a mouse model of Parkinson’s disease	18
Optimization of intracerebroventricular streptozotocin dose for the induction of neuroinflammation and memory impairments in rats	18
Intrinsically disordered proteins identified in the aggregate proteome serve as biomarkers of neurodegeneration	18
Effect of curcumin nanoparticles on streptozotocin-induced male Wistar rat model of Alzheimer’s disease	18
Chronic fatigue syndrome and fibromyalgia-like symptoms are an integral component of the phenome of schizophrenia: neuro-immune and opioid system correlates	17
Accelerated epigenetic aging in adolescents from low-income households is associated with altered development of brain structures	17
PI3K/AKT/mTOR signalling inhibitor chrysophanol ameliorates neurobehavioural and neurochemical defects in propionic acid-induced experimental model of autism in adult rats	17
Biochemical, histological, and neuro-physiological effects of long-term aluminum chloride exposure in rats	17
Pinocembrin pretreatment counteracts the chlorpyrifos-induced HO-1 downregulation, mitochondrial dysfunction, and inflammation in the SH-SY5Y cells	16
Antiparkinsonian activity of Cucurbita pepo seeds along with possible underlying mechanism	16
Moderate-intensity continuous training and high-intensity interval training improve cognition, and BDNF levels of middle-aged overweight men	16
Mercury and Alzheimer’s disease: a look at the links and evidence	16
Paeonol ameliorates CFA-induced inflammatory pain by inhibiting HMGB1/TLR4/NF-κB p65 pathway	16
Linking chronic kidney disease and Parkinson’s disease: a literature review	16
Alzheimer’s disease improved through the activity of mitochondrial chain complexes and their gene expression in rats by boswellic acid	16
Combination of donepezil and gallic acid improves antioxidant status and cholinesterases activity in aluminum chloride-induced neurotoxicity in Wistar rats	15
The role of long non-coding RNA MALAT1 in patients with bipolar disorder	15
Moringa oleifera-supplemented diet protect against cortico-hippocampal neuronal degeneration in scopolamine-induced spatial memory deficit in mice: role of oxido-inflammatory and cholinergic neurotran	15
Downregulation of lncRNA MEG3 is involved in Parkinson’s disease	15
Probiotics ameliorates LPS induced neuroinflammation injury on Aβ 1–42, APP, γ-β secretase and BDNF levels in maternal gut microbiota and fetal neurodevelopment processes	15

A short review on cross-link between pyruvate kinase (PKM2) and Glioblastoma Multiforme	15
NMR-based metabolomics characterizes metabolic changes in different brain regions of streptozotocin-induced diabetic mice with cognitive decline	15
Additional methodological considerations regarding optimization of the dose of intracerebroventricular streptozotocin A response to: “Optimization of intracerebroventricular streptozotocin dose for th	14
Metabolism in Huntington’s disease: a major contributor to pathology	14
Regulation of AKT/AMPK signaling, autophagy and mitigation of apoptosis in Rutin-pretreated SH-SY5Y cells exposed to MPP+	14
A novel hippocampus metabolite signature in diabetes mellitus rat model of diabetic encephalopathy	14
Salidroside inhibited cerebral ischemia/reperfusion-induced oxidative stress and apoptosis via Nrf2/Trx1 signaling pathway	14
Recent advances in tau-directed immunotherapy against Alzheimer’s disease: an overview of pre-clinical and clinical development	14
Asiatic acid attenuates aluminium chloride-induced behavioral changes, neuronal loss and astrocyte activation in rats	14
Neuroprotective effects of metformin on traumatic brain injury in rats is associated with the AMP-activated protein kinase signaling pathway	14
Hydroxychloroquine effects on miR-155-3p and miR-219 expression changes in animal model of multiple sclerosis	14
Dichloroacetic acid-induced dysfunction in rat hippocampus and the protective effect of curcumin	14
Advances in intervention methods and brain protection mechanisms of in situ and remote ischemic postconditioning	14
Lipid metabolic dysregulation is involved in Parkinson’s disease dementia	14
Metabolomics of ischemic stroke: insights into risk prediction and mechanisms	13
Endosomal‐lysosomal dysfunctions in Alzheimer’s disease: Pathogenesis and therapeutic interventions	13
Potential of nobiletin against Alzheimer’s disease through inhibiting neuroinflammation	13
Association of lncRNA with regulatory molecular factors in brain and their role in the pathophysiology of schizophrenia	13
Psychometric methods for diagnosing and monitoring minimal hepatic encephalopathy —current validation level and practical use	13
Changes in expressions of genes involved in the regulation of cellular processes in mucopolysaccharidoses as assessed by fibroblast culture-based transcriptomic analyses	13
Epigallocatechin-3-gallate improves chronic alcohol-induced cognitive dysfunction in rats by interfering with neuro-inflammatory, cell death and oxido-nitrosative cascade	13
Unravelling the potential neuroprotective facets of erythropoietin for the treatment of Alzheimer’s disease	13
Exercise training ameliorates cognitive dysfunction in amyloid beta-injected rat model: possible mechanisms of Angiostatin/VEGF signaling	13
Nobiletin prevents amyloid β1-40-induced cognitive impairment via inhibition of neuroinflammation and oxidative/nitrosative stress	13
Circular RNA circLIFR regulates the proliferation, migration, invasion and apoptosis of human vascular smooth muscle cells via the miR-1299/KDR axis	13
Reserpine-induced altered neuro-behavioral, biochemical and histopathological assessments prevent by enhanced antioxidant defence system of thymoquinone in mice	13
Flavonoids modulate AMPK/PGC-1α and interconnected pathways toward potential neuroprotective activities	13
Cedrol protects against chronic constriction injury-induced neuropathic pain through inhibiting oxidative stress and inflammation	13
Effect of a purine derivative containing selenium to improve memory decline and anxiety through modulation of the cholinergic system and Na+/K+-ATPase in an Alzheimer’s disease model	12
Adult human neurogenesis: early studies clarify recent controversies and go further	12
LncRNA SNHG7 sponges miR-449a to promote pituitary adenomas progression	12
Exosomes from human umbilical cord Mesenchymal stem cells attenuates stress-induced hippocampal dysfunctions	12
Current and emerging therapeutic targets for Parkinson’s disease	12
Benefits of betanin in rotenone-induced Parkinson mice	12
Serum fractalkine and 3-nitrotyrosine levels correlate with disease severity in Parkinson’s disease: a pilot study	12
Exogenous hydrogen sulfide restores CSE and CBS but no 3-MST protein expression in the hypothalamus and brainstem after severe traumatic brain injury	12
Ruxolitinib in Aicardi-Goutières syndrome	12
Circulating sortilin levels are associated with inflammation in patients with moyamoya disease	12
Drug delivery for neuronopathic lysosomal storage diseases: evolving roles of the blood brain barrier and cerebrospinal fluid	12
Ginkgolide B inactivates the NLRP3 inflammasome by promoting autophagic degradation to improve learning and memory impairment in Alzheimer’s disease	12
Effect of Sanguisorba minor on scopolamine-induced memory loss in rat: involvement of oxidative stress and acetylcholinesterase	12
Folic acid attenuated learning and memory impairment via inhibition of oxidative damage and acetylcholinesterase activity in hypothyroid rats	12
Gut brain axis: an insight into microbiota role in Parkinson’s disease	11
Blood–brain barrier leakage and perivascular collagen accumulation precede microvessel rarefaction and memory impairment in a chronic hypertension animal model	11
Laterality and sex differences in the expression of brain-derived neurotrophic factor in developing rat hippocampus	11
Metabolomic analysis of animal models of depression	11
Association between thyroid function and Alzheimer's disease: A systematic review	11
Lower uric acid level may be associated with hemorrhagic transformation but not functional outcomes in patients with anterior circulation acute ischemic stroke undergoing endovascular thrombectomy	11
Skimmetin/osthole mitigates pain-depression dyad via inhibiting inflammatory and oxidative stress-mediated neurotransmitter dysregulation	11
Amelioration of motor and non-motor deficits and increased striatal APoE levels highlight the beneficial role of pistachio supplementation in rotenone-induced rat model of PD	11
Epilepsy in inherited neurotransmitter disorders: Spotlights on pathophysiology and clinical management	11
An overview of the orexinergic system in different animal species	11
Neuroprotective role of Diosgenin, a NGF stimulator, against Aβ (1–42) induced neurotoxicity in animal model of Alzheimer’s disease	11
The effects of thymoquinone on memory impairment and inflammation in rats with hepatic encephalopathy induced by thioacetamide	11
Folic acid prevents habituation memory impairment and oxidative stress in an aging model induced by D-galactose	11
Remote ischemic preconditioning protects against cerebral ischemia injury in rats by upregulating miR-204-5p and activating the PINK1/Parkin signaling pathway	11
Effects of inhibiting astrocytes and BET/BRD4 chromatin reader on spatial memory and synaptic proteins in rats with Alzheimer’s disease	11
Exploring the Potential Antidepressant Mechanisms of Pinellia by Using the Network Pharmacology and Molecular Docking	11
Evidence for inflammasome activation in the brain of mucopolysaccharidosis type II mice	10
Thioacetamide-induced acute hepatic encephalopathy: central vs peripheral effect of Allicin	10
Neuroprotective effects of carvacrol against cadmium-induced neurotoxicity in rats: role of oxidative stress, inflammation and apoptosis	10
The potential role of Keap1-Nrf2 pathway in the pathogenesis of Alzheimer’s disease, type 2 diabetes, and type 2 diabetes-related Alzheimer’s disease	10
Therapeutic hypothermia augments the restorative effects of PKC-β and Nox2 inhibition on an in vitro model of human blood–brain barrier	10
Analysis of expression profiles and bioinformatics suggests that plasma exosomal circular RNAs may be involved in ischemic stroke in the Chinese Han population	10
Administration of Selenium Nanoparticles Reverses Streptozotocin-Induced Neurotoxicity in the male rats	10
Adiponectin: a potential target for obesity-associated Alzheimer’s disease	10
Possible role of rice bran extract in microglial modulation through PPAR-gamma receptors in alzheimer’s disease mice model	10
Effects of physical exercise on memory in type 2 diabetes: a brief review	10
Oxidative stress in phenylketonuria—evidence from human studies and animal models, and possible implications for redox signaling	10
Manifestation of renin angiotensin system modulation in traumatic brain injury	10
Neuroprotective effects of coenzyme Q10 in Parkinson's model via a novel Q10/miR-149-5p/MMPs pathway	9
LncRNA NEAT1 ameliorate ischemic stroke via promoting Mfn2 expression through binding to Nova and activates Sirt3	9
Neurobehavioral alterations in a mouse model of chronic partial sleep deprivation	9
Carotid intima media thickness measurements coupled with stroke severity strongly predict short-term outcome in patients with acute ischemic stroke: a machine learning study	9
Prevention of post-tips hepatic encephalopathy: The search of the ideal candidate	9
Neuroprotective effect of herniarin following transient focal cerebral ischemia in rats	9
Toxoplasmosis: Targeting neurotransmitter systems in psychiatric disorders	9
Ketamine, but not fluoxetine, rapidly rescues corticosterone-induced impairments on glucocorticoid receptor and dendritic branching in the hippocampus of mice	9
Modification of methods to use Congo-red stain to simultaneously visualize amyloid plaques and tangles in human and rodent brain tissue sections	9
Baicalin attenuates inflammatory pain associated depressive symptoms via Akt-mediated adult hippocampal neurogenesis	9

The critical role of gut-brain axis microbiome in mental disorders	9
Alzheimer’s disease therapy based on acetylcholinesterase inhibitor/blocker effects on voltage-gated potassium channels	9
Expression of BDNF-Associated lncRNAs in Parkinson’s disease	9
A network pharmacology study with molecular docking to investigate the possibility of licorice against posttraumatic stress disorder	9
Thrombin generation and activity in multiple sclerosis	9
Momordica charantia polysaccharide ameliorates D-galactose-induced aging through the Nrf2/β-Catenin signaling pathway	9
Oxytocin levels in individuals with schizophrenia are high in cerebrospinal fluid but low in serum: A systematic review and meta-analysis	9
Association study of a single nucleotide polymorphism in brain cytoplasmic 200 long-noncoding RNA and psychiatric disorders	9
D-beta-hydroxybutyrate protects against microglial activation in lipopolysaccharide-treated mice and BV-2 cells	9
Hepatoprotective and neuroprotective effect of taxifolin on hepatic encephalopathy in rats	9
Alpha lipoic acid ameliorates scopolamine induced memory deficit and neurodegeneration in the cerebello-hippocampal cortex	9
EIF4A3-induced circCCNB1 (hsa_circ_0001495) promotes glioma progression by elevating CCND1 through interacting miR-516b-5p and HuR	9
Paeoniflorin ameliorates cognitive impairment in Parkinson’s disease via JNK/p53 signaling	8
Identification of methylation markers for diagnosis of autism spectrum disorder	8
MEG3 lncRNA is over-expressed in autism spectrum disorder	8
Neurotoxic and behavioral deficit in Drosophila melanogaster co-exposed to rotenone and iron	8
Intricate role of sleep deprivation in modulating depression: focusing on BDNF, VEGF, serotonin, cortisol, and TNF-α	8
Cognition-tracking-based strategies for diagnosis and treatment of minimal hepatic encephalopathy	8
The orphan nuclear receptor Nurr1 agonist amodiaquine mediates neuroprotective effects in 6-OHDA Parkinson’s disease animal model by enhancing the phosphorylation of P38 mitogen-activated kinase but n	8
Involvement of anti-inflammatory, antioxidant, and BDNF up-regulating properties in the antipsychotic-like effect of the essential oil of Alpinia zerumbet in mice: a comparative study with olanzapine	8
Mood disorders are associated with the reduction of brain derived neurotrophic factor in the hypocampus in rats submitted to the hipercaloric diet	8
One drug to treat many diseases: unlocking the economic trap of rare diseases	8
Pathology-supported genetic testing as a method for disability prevention in multiple sclerosis (MS). Part I. Targeting a metabolic model rather than autoimmunity	8
The C-glucosyl flavone isoorientin pretreatment attenuates the methylglyoxal-induced mitochondrial dysfunction in the human neuroblastoma SH-SY5Y cells: role for the AMPK-PI3K/Akt/Nrf2/γ-GCL/GSH axis	8
DNACJ12 deficiency in patients with unexplained hyperphenylalaninemia: two new patients and a novel variant	8
Knockdown of circ_0007290 alleviates oxygen-glucose deprivation-induced neuronal injury by regulating miR-496/PDCD4 axis	8
Beneficial effects of levetiracetam in streptozotocin-induced rat model of Alzheimer’s disease	8
Effects of safflower yellow on cholesterol levels in serum and brain tissue of APP/PS1 mice	8
Long term high fat diet induces metabolic disorders and aggravates behavioral disorders and cognitive deficits in MAPT P301L transgenic mice	8
Circular RNA: A novel and potential regulator in pathophysiology of schizophrenia	8
Association of genetic variants of ABCA1 with susceptibility to dementia: (SADEM study)	8
Circular RNA circ-ARFIP2 regulates proliferation, migration and invasion in human vascular smooth muscle cells via miR-338-3p-dependent modulation of KDR	8
The metabolic effect of α-ketoisocaproic acid: in vivo and in vitro studies	8
AMPK-dependent autophagy activation and alpha-Synuclein clearance: a putative mechanism behind alpha-mangostin’s neuroprotection in a rotenone-induced mouse model of Parkinson’s disease	8
The role of lipid peroxidation in individuals with autism spectrum disorders	8
Preventive effects of arctigenin from Arctium lappa L against LPS-induced neuroinflammation and cognitive impairments in mice	8
Beta amyloid-induced time-dependent learning and memory impairment: involvement of HPA axis dysfunction	8
Ursolic acid abrogates depressive-like behavior and hippocampal pro-apoptotic imbalance induced by chronic unpredictable stress	8
Therapeutic potential of probiotics – Lactobacillus plantarum UBLP40 and Bacillus clausii UBBC07 on thioacetamide-induced acute hepatic encephalopathy in rats	8