OOIR: Observatory of International Research

Papers

(The TQCC of Metabolic Brain Disease is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Tetramethylpyrazine protects neural stem cells against sevoflurane-induced toxicity through Akt/GSK-3β pathway	97
Knowledge about the characteristics of stroke-like lesions is expandable	91
Jobelyn® extends the life span and improves motor function in Drosophila melanogaster exposed to lipopolysaccharide via augmentation of antioxidant status	63
Amelioration of intracerebroventricular streptozotocin-induced cognitive dysfunction by Ocimum sanctum L. through the modulation of inflammation and GLP-1 levels	58
Retraction Note to: Ocimum basilicum attenuates ethidium bromide-induced cognitive deficits and pre-frontal cortical neuroinflammation, astrogliosis and mitochondrial dysfunction in rats	57
Clonidine ameliorates cerebral ischemia–reperfusion injury by up-regulating the GluN3 subunits of NMDA receptor	56
The effect of chronic stress and its preconditioning on spatial memory as well as hippocampal LRP1 and RAGE expression in a streptozotocin-induced rat model of Alzheimer’s disease	52
Tramadol induces apoptosis, inflammation, and oxidative stress in rat choroid plexus	48
Conditioned medium of human menstrual blood-derived endometrial stem cells protects against cell inflammation and apoptosis of Npc1KO N2a cells	43
Hesperetin ameliorates diabetes-associated anxiety and depression-like behaviors in rats via activating Nrf2/ARE pathway	43
cAMP/PKA-CREB-BDNF signaling pathway in hippocampus of rats subjected to chemically-induced phenylketonuria	39
Anti-inflammatory, anti-apoptotic, and neuroprotective potentials of anethole in Parkinson’s disease-like motor and non-motor symptoms induced by rotenone in rats	38
Stellate ganglion block suppresses hippocampal ferroptosis to attenuate cerebral ischemia-reperfusion injury via the Hippo pathway	36
Coadministration of tianeptine alters behavioral parameters and levels of neurotrophins in a chronic model of Maple Syrup Urine disease	34
Clinical features, pathogenesis, and management of stroke-like episodes due to MELAS	34
Sevoflurane impedes glioma progression via regulating circ_0000215/miR-1200/NCR3LG1 axis	34
Inhibition of hyperpolarization-activated cyclic nucleotide-gated cation channel attenuates cerebral ischemia reperfusion-induced impairment of learning and memory by regulating apoptotic pathway	34
Network activity changes in the pathophysiology of Alzheimer’s disease: the role of aging and early entorhinal cortex dysfunction	33
Therapeutic hypothermia for the treatment of neonatal hypoxia-ischemia: sex-dependent modulation of reactive astrogliosis	32
Flavonoid-enrich extract of Autranella congolensis (Sapotaceae) protects against aluminium chloride-mediated Alzheimer’s disease-like oxidative stress in rat through the antioxidant properties	31
3-Methyladenine ameliorates surgery-induced anxiety-like behaviors in aged mice by inhibiting autophagy-induced excessive oxidative stress	31
Deterioration of visual quality and acuity as the first sign of ceroid lipofuscinosis type 3 (CLN3), a rare neurometabolic disease	28
Asiatic acid attenuates aluminium chloride-induced behavioral changes, neuronal loss and astrocyte activation in rats	28
Paraoxonase 1 status is a major Janus-faced component of mild and moderate acute ischemic stroke and consequent disabilities	28
Complete Loss of Myelin protein zero (MPZ) in a patient with a late onset Charcot-Marie-Tooth (CMT)	26

Hepatic glycogen participates in the regulation of hypothalamic pAkt/Akt ratio in high-sugar/high-fat diet-induced obesity	26
Retraction Note: Effects of Rosemary Oil (Rosmarinus officinalis) supplementation on the fate of the transplanted human olfactory bulb neural stem cells against ibotenic acid-induced neurotoxicity (Al	26
Differential involvement of hippocampal subfields in Niemann-Pick type C disease: a case–control study	26
MiR-487b suppressed inflammation and neuronal apoptosis in spinal cord injury by targeted Ifitm3	25
Identification of methylation markers for diagnosis of autism spectrum disorder	25
Necroptosis in the developing brain: role in neurodevelopmental disorders	25
Decrypting the cellular and molecular intricacies associated with COVID-19-induced chronic pain	24
Paeoniflorin ameliorates cognitive impairment in Parkinson’s disease via JNK/p53 signaling	24
Correction to: Toxicity of ayahuasca after 28 days daily exposure and effects on monoamines and brain-derived neurotrophic factor (BDNF) in brain of Wistar rats	24
A pilot study on glutamate receptor and carrier gene variants and risk of childhood autism spectrum	24
Taurine supplementation improves hippocampal metabolism in immature rats with intrauterine growth restriction (IUGR) through protecting neurons and reducing gliosis	24
Transient neonatal hyperglycemia induces metabolic shifts in the rat hippocampus: a 1H NMR-based metabolomics analysis	22
Quercetin mitigates scopolamine-induced memory dysfunction: impact on oxidative stress and cholinergic mechanisms	22
Multimodal MRI in Leigh syndrome due to m.13513G > A	20
Neuroprotective effects of carvacrol against cadmium-induced neurotoxicity in rats: role of oxidative stress, inflammation and apoptosis	20
Association between MAP3K4 gene polymorphisms and the risk of schizophrenia susceptibility in a Northeast Chinese Han population	20
Unravelling the potential neuroprotective facets of erythropoietin for the treatment of Alzheimer’s disease	20
Neuroprotective effects of methyl jasmonate in male Wistar rats exposed to delayed acetic acid-induced ulcerative colitis: involvement of antioxidant status, GFAP, and IBA-1 immunoreactivities	20
Stem cell therapy combined with luteolin alleviates experimental neuropathy	19
Peripheral viral challenge increases c-fos level in cerebral neurons	19
A rare cause of hydrops fetalis in two Gaucher disease type 2 patients with a novel mutation	19
Exposure to leucine alters glutamate levels and leads to memory and social impairment in zebrafish	19
The association of stem cell factor and soluble c-Kit (s-cKit) receptor serum concentrations with the severity and risk prediction of autism spectrum disorders	19
Effects of physical exercise on memory in type 2 diabetes: a brief review	18
Anti-apoptotic capacity of MALAT1 on hippocampal neurons correlates with CASP3 DNA methylation in a mouse model of autism	18
Adenosine protects D-galactose induced alterations in rat model of aging via attenuating neurochemical profile and redox status	18
Association of 3-hydroxy-3-methylglutaryl-coenzyme A reductase gene polymorphism with obesity and lipid metabolism in children and adolescents with autism spectrum disorder	18
RETRACTED ARTICLE: Effects of Rosemary Oil (Rosmarinus officinalis) supplementation on the fate of the transplanted human olfactory bulb neural stem cells against ibotenic acid-induced neurotoxicity (	18
The effect of salmon calcitonin against glutamate-induced cytotoxicity in the C6 cell line and the roles the inflammatory and nitric oxide pathways play	18
Crosstalk between Alzheimer’s disease and diabetes: a focus on anti-diabetic drugs	18
Correction to: Necrostatin-1 S mitigates type-2 diabetes-associated cognitive decrement and lipotoxicity-induced neuro-microglia changes through p-RIPK-RIPK3-p-MLKL axis	18
Associations between GRM7 polymorphisms and obesity in patients selected for sleeve gastrectomy	18
Estrogen signaling via estrogen receptor alpha and its implications for neurodegeneration associated with Alzheimer’s disease in aging women	18
Therapeutic potential of endoplasmic reticulum stress inhibitors in the treatment of diabetic peripheral neuropathy	18
Correction to: Castor1 overexpression regulates microglia M1/M2 polarization via inhibiting mTOR pathway	18
Astragalin alleviates cognitive deficits and neuronal damage in SAMP8 mice through upregulating estrogen receptor expression	18
The role of brain inflammation and abnormal brain oxygen homeostasis in the development of hepatic encephalopathy	17
J-difference GABA-edited MRS reveals altered cerebello-thalamo-cortical metabolism in patients with hepatic encephalopathy	17
Imbalance of multiple neurotransmitter pathways leading to depression-like behavior and cognitive dysfunction in the triple transgenic mouse model of Alzheimer disease	17
1-benzoyl-6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline exerts a neuroprotective effect and normalises redox homeostasis in a rat model of cerebral ischemia/reperfusion	17
Proteomic advance of ischemic stroke: preclinical, clinical, and intervention	17
Hsa_circ_0043949 reinforces temozolomide resistance via upregulating oncogene ITGA1 axis in glioblastoma	17
Correction to: Methylphenidate disrupts cytoskeletal homeostasis and reduces membrane-associated lipid content in juvenile rat hippocampus	17
Convergent molecular mechanisms underlying cognitive impairment in mucopolysaccharidosis type II	17
Gossypetin- based therapeutics for cognitive dysfunction in chronic unpredictable stress- exposed mice	16
Psychometric methods for diagnosing and monitoring minimal hepatic encephalopathy —current validation level and practical use	16
Curcumin-resveratrol nano-formulation counteracting hyperammonemia in rats	16
Mesenchymal stem cell therapies for Alzheimer’s disease: preclinical studies	16
Activation of BDNF- and VEGF-mediated Neuroprotection by Treadmill Exercise Training in Experimental Stroke	16
Acute effects of intracerebroventricular administration of α-ketoisocaproic acid in young rats on inflammatory parameters	16

Functional SLC6A3 polymorphisms differentially affect autism spectrum disorder severity: a study on Indian subjects	16
Therapeutic approaches employing natural compounds and derivatives for treating bipolar disorder: emphasis on experimental models of the manic phase	16
Profiles of urine and blood metabolomics in autism spectrum disorders	15
Neuroprotective effect of green and roasted coffee bean extracts on cerebral ischemia-induced injury in rats	15
Nanoselenium improved learning, memory, and brain-derived neurotrophic factor and attenuated nitric oxide, and oxidative stress in the brain of juvenile hypothyroid rats	15
Impaired mitochondrial functions and energy metabolism in MPTP-induced Parkinson’s disease: comparison of mice strains and dose regimens	15
Predicting which patients with cirrhosis will develop overt hepatic encephalopathy: Beyond psychometric testing	15
Hsa_circ_0001361 facilitates cell progression and glycolytic metabolism in neuroblastoma via interacting with mir-490-5p to induce TRIM2 upregulation	15
miR-181a targets PTEN to mediate the neuronal injury caused by oxygen-glucose deprivation and reoxygenation	15
Circular RNA circ_0079593 facilitates glioma development via modulating miR-324-5p/XBP1 axis	15
Neuroinflammatory responses following zinc or branched-chain amino acids supplementation in obese rats	15
Effect of curcumin nanoparticles on streptozotocin-induced male Wistar rat model of Alzheimer’s disease	14
Kif15 deficiency contributes to depression-like behavior in mice	14
Circ_0003611 acts as a miR-885-5p sponge to aggravate the amyloid-β-induced neuronal injury in Alzheimer’s disease	14
Peripheral blood and urine metabolites and biological functions in post-stroke depression	14
Ferrous sulfate reverses cerebral metabolic abnormality induced by minimal hepatic encephalopathy	14
A novel homozygous PIGO mutation associated with severe infantile epileptic encephalopathy, profound developmental delay and psychomotor retardation: structural and 3D modelling investigations and gen	14
MEG3 lncRNA is over-expressed in autism spectrum disorder	14
LPS-induced impairment of Na+/K+-ATPase activity: ameliorative effect of tannic acid in mice	14
Cannabidiol promotes neurogenesis in the dentate gyrus during an abstinence period in rats following chronic exposure to methamphetamine	14
Albumin therapy for hepatic encephalopathy: current evidence and controversies	14
A single injection of pregabalin induces short- and long-term beneficial effects on fear memory and anxiety-like behavior in rats with experimental type-1 diabetes mellitus	14
AMPK-dependent autophagy activation and alpha-Synuclein clearance: a putative mechanism behind alpha-mangostin’s neuroprotection in a rotenone-induced mouse model of Parkinson’s disease	14
Cerebrolysin reduces excitotoxicity by modulation of cell-death proteins in delayed hours of ischemic reperfusion injury	14
p-Coumaric acid protects against D-galactose induced neurotoxicity by attenuating neuroinflammation and apoptosis in mice brain	14
Effects of omega-3 fatty acid supplementation during chronic maternal hypoxia on behavioral disorders in male rat offspring: the role of Trk family and oxidative stress	13
Experimental evidence of tyrosine neurotoxicity: focus on mitochondrial dysfunction	13
Airway inflammation induces anxiety-like behavior through neuroinflammatory, neurochemical, and neurometabolic changes in an allergic asthma model	13
Association between lncRNA genetic variants and susceptibility to large artery atherosclerotic stroke	13
Captopril exhibits protective effects through anti-inflammatory and anti-apoptotic pathways against hydrogen peroxide-induced oxidative stress in C6 glioma cells	13
EIF4A3-induced circCCNB1 (hsa_circ_0001495) promotes glioma progression by elevating CCND1 through interacting miR-516b-5p and HuR	13
Sevoflurane represses the progression of glioma by the regulation of circ_0037655/miR-130a-5p/RPN2 axis	13
Potential of nobiletin against Alzheimer’s disease through inhibiting neuroinflammation	13
A multi-parameter evaluation of the neuroprotective and cognitive-enhancing effects of Origanum onites L. (Turkish Oregano) essential oil on scopolamine-induced amnestic rats	13
Protective effect of Juglanin against doxorubicin-induced cognitive impairment in rats: Effect on oxidative, inflammatory and apoptotic machineries	13
Assessing the Evolution of Intracranial Hematomas by using Animal Models: A Review of the Progress and the Challenges	13
Ligustilide ameliorates cognitive impairment via AMPK/SIRT1 pathway in vascular dementia rat	13
Immune-microbiome interplay and its implications in neurodegenerative disorders	13
p53 inhibits the Urea cycle and represses polyamine biosynthesis in glioma cell lines	13
Retraction Note to: Changes in Cathepsin D and Beclin-1 mRNA and protein expression by the excitotoxin quinolinic acid in human astrocytes and neurons	12
A novel LINC00943/miR-671-5p/ELAVL1 ceRNA crosstalk regulates MPP+ toxicity in SK-N-SH cells	12
Regulation of oxygen–glucose deprivation/reperfusion-induced inflammatory responses and M1-M2 phenotype switch of BV2 microglia by lobetyolin	12
Alzheimer’s disease therapy based on acetylcholinesterase inhibitor/blocker effects on voltage-gated potassium channels	12
Disorders of Tetrahydrobiopterin Metabolism: Experience from South India	12
Therapeutic potential of probiotics – Lactobacillus plantarum UBLP40 and Bacillus clausii UBBC07 on thioacetamide-induced acute hepatic encephalopathy in rats	12
Pathology and prevention of brain microvascular and neuronal dysfunction induced by a high-fructose diet in rats	12
Ketamine exerts dual effects on the apoptosis of primary cultured hippocampal neurons from fetal rats in vitro	12
Circular RNA circ_0021001 regulates miR-148b-3p/GREM1 axis to modulate proliferation and apoptosis of vascular smooth muscle cells	12
A novel protein truncating mutation in L2HGDH causes L-2-hydroxyglutaric aciduria in a consanguineous Pakistani family	12
Dysregulation of genes coding for proteins involved in metabolic processes in mucopolysaccharidoses, evidenced by a transcriptomic approach	12
Role of long noncoding RNAs; BDNF-AS and 17A and their relation to GABAergic dysfunction in Egyptian epileptic patients	12
Reserpine-induced altered neuro-behavioral, biochemical and histopathological assessments prevent by enhanced antioxidant defence system of thymoquinone in mice	12
Retraction Note to: Long non-coding RNA SNHG7 upregulates FGF9 to alleviate oxygen and glucose deprivation-induced neuron cell injury in a miR-134-5p-dependent manner	12
Correction to: A multi-parameter evaluation of the neuroprotective and cognitive-enhancing effects of Origanum onites L. (Turkish Oregano) essential oil on scopolamine-induced amnestic rats	12
miR-188-5p silencing improves cerebral ischemia/reperfusion injury by targeting Lin28a	12
Impaired ion homeostasis as a possible associate factor in mucopolysaccharidosis pathogenesis: transcriptomic, cellular and animal studies	12
Irisin attenuates ethanol-induced behavioral deficits in mice through activation of Nrf2 and inhibition of NF-κB pathways	12
RNA-seq analysis of ischemia stroke and normal brain in a tree shrew model with or without type 2 diabetes mellitus	12
D-beta-hydroxybutyrate protects against microglial activation in lipopolysaccharide-treated mice and BV-2 cells	12
Pseudoephedrine hydrochloride causes hyperactivity in zebrafish via modulation of the serotonin pathway	11
Neuroprotective effects of liraglutide against inflammation through the AMPK/NF-κB pathway in a mouse model of Parkinson’s disease	11
Circular RNA circ_0070441 regulates MPP+-triggered neurotoxic effect in SH-SY5Y cells via miR-626/IRS2 axis	11
Therapeutic hypothermia augments the restorative effects of PKC-β and Nox2 inhibition on an in vitro model of human blood–brain barrier	11
Promising protein biomarkers in the early diagnosis of Alzheimer’s disease	11
Drug delivery for neuronopathic lysosomal storage diseases: evolving roles of the blood brain barrier and cerebrospinal fluid	11
Deregulation of NF-κB associated long non-coding RNAs in bipolar disorder	11
PERK inhibitor, GSK2606414, ameliorates neuropathological damage, memory and motor functional impairments in cerebral ischemia via PERK/p-eIF2ɑ/ATF4/CHOP signaling	11
Abnormal grey matter structural changes in patients with end-stage kidney disease and mild cognitive impairment: correlations with clinical features	11
L-carnitine protects DNA oxidative damage induced by phenylalanine and its keto acid derivatives in neural cells: a possible pathomechanism and adjuvant therapy for brain injury in phenylketonuria	11
The role of carbonic anhydrase III and autophagy in type 2 diabetes with cardio-cerebrovascular disease	11
METTL7B contributes to the malignant progression of glioblastoma by inhibiting EGR1 expression	11
Neurological monitoring and sedation protocols in the Liver Intensive Care Unit	11
Ginkgo biloba extracts inhibit post-ischemic LTP through attenuating EPSCs in rat hippocampus	11
The brain neuropeptides and STAT3 mediate the inhibitory effect of 17-β Estradiol on central leptin resistance in young but not aged female high-fat diet mice	11
Long non-coding RNA Gm11974 aggravates oxygen–glucose deprivation-induced injury via miR-122-5p/SEMA3A axis in ischaemic stroke	11
LncRNA CRNDE binds hnRNPA1 to facilitate carbon monoxide poisoning-induced delayed encephalopathy via inhibiting UCHL5-mediated SMO deubiquitination	11