Metabolic Brain Disease

Article	Citations
AMPK-dependent autophagy activation and alpha-Synuclein clearance: a putative mechanism behind alpha-mangostin’s neuroprotection in a rotenone-induced mouse model of Parkinson’s disease	122
Neuroprotective effect of mildronate and L-carnitine on the cognitive parameters of aged mice and mice with LPS-induced inflammation	95
Saffron and crocin ameliorate prenatal valproic acid-induced autistic-like behaviors and brain oxidative stress in the male offspring rats	88
Functional importance of glucose transporters and chromatin epigenetic factors in Glioblastoma Multiforme (GBM): possible therapeutics	61
Mangiferin exerts neuroprotective effects against focal cerebral ischemia in mice by regulating NF-κB signaling pathway	57
Manifestation of renin angiotensin system modulation in traumatic brain injury	51
Genotypic and phenotypic features in Turkish patients with classic nonketotic hyperglycinemia	50
Effects of a novel probiotic mixture on the modulation of brain and intestine Aquaporin-4 gene expression in rats exposed to Cadmium	49
Anti-Caspr-conjugated gold nanoparticles emergence as a novel approach in the treatment of EAE animal model	43
Circ_RPPH1 regulates glioma cell malignancy by binding to miR-627-5p/miR-663a to induce SDC1 expression	42
Exogenous IGF-1 improves tau pathology and neuronal pyroptosis in high-fat diet mice with cognitive dysfunction	39
Effect of Sanguisorba minor on scopolamine-induced memory loss in rat: involvement of oxidative stress and acetylcholinesterase	37
cAMP/PKA-CREB-BDNF signaling pathway in hippocampus of rats subjected to chemically-induced phenylketonuria	34
Anti-inflammatory, anti-apoptotic, and neuroprotective potentials of anethole in Parkinson’s disease-like motor and non-motor symptoms induced by rotenone in rats	32
Targeting inflammation: a potential approach for the treatment of depression	32
Amelioration of intracerebroventricular streptozotocin-induced cognitive dysfunction by Ocimum sanctum L. through the modulation of inflammation and GLP-1 levels	31
Branched-chain amino acids (BCAA) administration increases autophagy and the autophagic pathway in brain tissue of rats submitted to a Maple Syrup Urine Disease (MSUD) protocol	30
Emerging role of extracellular vesicles in the pathogenesis of glioblastoma	30
The effect of chronic stress and its preconditioning on spatial memory as well as hippocampal LRP1 and RAGE expression in a streptozotocin-induced rat model of Alzheimer’s disease	30
TRPV1 stimulation increased oxidative neurotoxicity and apoptosis in the glia cell membrane but not in the perinuclear area: An evidence of TRPV1 subtype	29
Knockdown of circHECTD1 inhibits oxygen-glucose deprivation and reperfusion induced endothelial-mesenchymal transition	29
Diabetes mellitus – risk factor and potential future target for hepatic encephalopathy in patients with liver cirrhosis?	29
Jobelyn® extends the life span and improves motor function in Drosophila melanogaster exposed to lipopolysaccharide via augmentation of antioxidant status	27
Tetramethylpyrazine protects neural stem cells against sevoflurane-induced toxicity through Akt/GSK-3β pathway	27
Momordica charantia polysaccharide ameliorates D-galactose-induced aging through the Nrf2/β-Catenin signaling pathway	26

Effect of Solanum vegetables on memory index, redox status, and expressions of critical neural genes in Drosophila melanogaster model of memory impairment	25
Partial changes in apoptotic pathways in hippocampus and hypothalamus of Cc2d1a heterozygous	25
Effect of curcumin nanoparticles on streptozotocin-induced male Wistar rat model of Alzheimer’s disease	24
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure	24
Prophylactic effects of cucurbitacin B in the EAE Model of multiple sclerosis by adjustment of STAT3/IL-23/IL-17 axis and improvement of neuropsychological symptoms	24
Cerebrolysin reduces excitotoxicity by modulation of cell-death proteins in delayed hours of ischemic reperfusion injury	23
Tramadol induces apoptosis, inflammation, and oxidative stress in rat choroid plexus	23
Exogenous hydrogen sulfide restores CSE and CBS but no 3-MST protein expression in the hypothalamus and brainstem after severe traumatic brain injury	22
A single injection of pregabalin induces short- and long-term beneficial effects on fear memory and anxiety-like behavior in rats with experimental type-1 diabetes mellitus	22
p-Coumaric acid protects against D-galactose induced neurotoxicity by attenuating neuroinflammation and apoptosis in mice brain	21
Vitamin B1 deficiency leads to high oxidative stress and mtDNA depletion caused by SLC19A3 mutation in consanguineous family with Leigh syndrome	21
Knowledge about the characteristics of stroke-like lesions is expandable	20
Inhibition of hyperpolarization-activated cyclic nucleotide-gated cation channel attenuates cerebral ischemia reperfusion-induced impairment of learning and memory by regulating apoptotic pathway	20
The potential role of Keap1-Nrf2 pathway in the pathogenesis of Alzheimer’s disease, type 2 diabetes, and type 2 diabetes-related Alzheimer’s disease	20
Involvement of the nociceptin opioid peptide receptor in morphine-induced antinociception, tolerance and physical dependence in female mice	20
MEG3 lncRNA is over-expressed in autism spectrum disorder	20
Neuroprotective effect of green and roasted coffee bean extracts on cerebral ischemia-induced injury in rats	19
MALDI imaging mass spectrometry: an emerging tool in neurology	18
Alzheimer’s disease: a step closer to understanding type 3 diabetes in African Americans	18
Conditioned medium of human menstrual blood-derived endometrial stem cells protects against cell inflammation and apoptosis of Npc1KO N2a cells	18
Morus alba fruit diet ameliorates cognitive deficit in mouse model of streptozotocin-induced memory impairment	18
DNACJ12 deficiency in patients with unexplained hyperphenylalaninemia: two new patients and a novel variant	18
Integrated pathway and network analyses of metabolomic alterations in peripheral blood of patients with depression	18
Nitrosative stress parameters and the level of oxidized DNA bases in patients with multiple sclerosis	17
A kinetic scheme to examine the role of glial cells in the pathogenesis of Alzheimer’s disease	17
Pre-weaning fluoxetine exposure caused anti-depressant like behavior at adulthood via perturbing tryptophan metabolism in rats	17
MicroRNA-32-5p attenuates cerebral ischemia/reperfusion injuries by modulating the phosphatase and tensin homologous protein	17
Gut brain axis: an insight into microbiota role in Parkinson’s disease	17
Anticonvulsant activity of methanolic extract of Withania cogulans in mice	17
Alcohol binge drinking decreases brain glucose metabolism and functional connectivity in adolescent rats	17
Hsa_circ_0001361 facilitates cell progression and glycolytic metabolism in neuroblastoma via interacting with mir-490-5p to induce TRIM2 upregulation	17
Bioinformatics investigation on blood-based gene expressions of Alzheimer's disease revealed ORAI2 gene biomarker susceptibility: An explainable artificial intelligence-based approach	17
Neuroinflammatory responses following zinc or branched-chain amino acids supplementation in obese rats	17
Exploring the potential anti-Alzheimer disease mechanisms of Alpiniae Oxyphyliae Fructus by network pharmacology study and molecular docking	16
Partial blood replacement ameliorates middle cerebral artery occlusion generated neurological aberrations by intervening TLR4 and NLRP3 cascades in rats	16
Clonidine ameliorates cerebral ischemia–reperfusion injury by up-regulating the GluN3 subunits of NMDA receptor	16
Stellate ganglion block suppresses hippocampal ferroptosis to attenuate cerebral ischemia-reperfusion injury via the Hippo pathway	16
The protective effect of inhibiting mitochondrial fission on the juvenile rat brain following PTZ kindling through inhibiting the BCL2L13/LC3 mitophagy pathway	16
Moringa oleifera-supplemented diet protect against cortico-hippocampal neuronal degeneration in scopolamine-induced spatial memory deficit in mice: role of oxido-inflammatory and cholinergic neurotran	16
Progressive transcriptional changes in metabolic genes and altered fatbody homeostasis in Drosophila model of Huntington’s disease	16
The role of excitatory amino acid transporter 2 (EAAT2) in epilepsy and other neurological disorders	16
Gold nanoparticles application to the treatment of brain dysfunctions related to metabolic diseases: evidence from experimental studies	16
Potential mechanisms underlying the association between type II diabetes mellitus and cognitive dysfunction in rats: a link between miRNA-21 and Resveratrol’s neuroprotective action	16
Apelin–13 protects against memory impairment and neuronal loss, Induced by Scopolamine in male rats	16
The extract of Sclerocarya birrea, Nauclea latifolia, and Piper longum mixture ameliorates diabetes-associated cognitive dysfunction	16
Oxytocin levels in individuals with schizophrenia are high in cerebrospinal fluid but low in serum: A systematic review and meta-analysis	16
Nanoselenium improved learning, memory, and brain-derived neurotrophic factor and attenuated nitric oxide, and oxidative stress in the brain of juvenile hypothyroid rats	15
Confusion assessment method accurately screens for hepatic encephalopathy and predicts short-term mortality in hospitalized patients with cirrhosis	15
Withania coagulans extract attenuates oxidative stress-mediated apoptosis of cerebellar purkinje neurons after ischemia/reperfusion injury	15
Retraction Note to: Ocimum basilicum attenuates ethidium bromide-induced cognitive deficits and pre-frontal cortical neuroinflammation, astrogliosis and mitochondrial dysfunction in rats	15

Neurotoxic and behavioral deficit in Drosophila melanogaster co-exposed to rotenone and iron	15
The network pharmacology study and molecular docking to investigate the potential mechanism of Acoritataninowii Rhizoma against Alzheimer's Disease	15
Sevoflurane impedes glioma progression via regulating circ_0000215/miR-1200/NCR3LG1 axis	15
Genistein attenuates neuroinflammation and oxidative stress and improves cognitive impairment in a rat model of sepsis-associated encephalopathy: potential role of the Nrf2 signaling pathway	15
Celastrol assuages oxygen-glucose deprivation and reoxygenation-induced damage in human brain microvascular endothelial cells through the circDLGAP4/miR-6085/GDF11 pathway	15
LncRNA SNHG14 is beneficial to oxygen glucose deprivation/reoxygenation-induced neuro-2a cell injury via mir-98-5p sequestration-caused BCL2L13 upregulation	15
Adiponectin: a potential target for obesity-associated Alzheimer’s disease	14
Hesperetin ameliorates diabetes-associated anxiety and depression-like behaviors in rats via activating Nrf2/ARE pathway	14
Circular RNA circ_0079593 facilitates glioma development via modulating miR-324-5p/XBP1 axis	14
Circ_0000011 promotes cerebral ischemia/reperfusion injury via miR-27a-3p-dependent regulation of NRIP1	14
Epigenetic regulation and autophagy modulation debilitates insulin resistance associated Alzheimer’s disease condition in rats	14
Crosstalk between Sirtuins and Nrf2: SIRT1 activators as emerging treatment for diabetic neuropathy	14
Correction to: Indian ginseng (Withania somnifera) supplementation ameliorates oxidative stress and mitochondrial dysfunctions in experimental model of stroke	14
Predicting which patients with cirrhosis will develop overt hepatic encephalopathy: Beyond psychometric testing	13
Peripheral blood and urine metabolites and biological functions in post-stroke depression	13
Probiotics ameliorates LPS induced neuroinflammation injury on Aβ 1–42, APP, γ-β secretase and BDNF levels in maternal gut microbiota and fetal neurodevelopment processes	13
LncRNA NEAT1 ameliorate ischemic stroke via promoting Mfn2 expression through binding to Nova and activates Sirt3	13
Folic acid attenuated learning and memory impairment via inhibition of oxidative damage and acetylcholinesterase activity in hypothyroid rats	13
The C-glucosyl flavone isoorientin pretreatment attenuates the methylglyoxal-induced mitochondrial dysfunction in the human neuroblastoma SH-SY5Y cells: role for the AMPK-PI3K/Akt/Nrf2/γ-GCL/GSH axis	13
Intrinsically disordered proteins identified in the aggregate proteome serve as biomarkers of neurodegeneration	13
Clinical features, pathogenesis, and management of stroke-like episodes due to MELAS	13
Blood-based biomarkers in Alzheimer’s disease: a mini-review	13
The effect of URB597, exercise or their combination on the performance of 6-OHDA mouse model of Parkinson disease in the elevated plus maze, tail suspension test and step-down task	13
Reactive gliosis in Alzheimer’s disease: a crucial role for cognitive impairment and memory loss	12
Circ_0003611 acts as a miR-885-5p sponge to aggravate the amyloid-β-induced neuronal injury in Alzheimer’s disease	12
EIF4A3-induced circCCNB1 (hsa_circ_0001495) promotes glioma progression by elevating CCND1 through interacting miR-516b-5p and HuR	12
KIAA0101 knockdown inhibits glioma progression and glycolysis by inactivating the PI3K/AKT/mTOR pathway	12
Exploring the Potential Antidepressant Mechanisms of Pinellia by Using the Network Pharmacology and Molecular Docking	12
NBAS deficiency due to biallelic c.2809C > G variant presenting with recurrent acute liver failure with severe hyperammonemia, acquired microcephaly and progressive brain atrophy	12
Kif15 deficiency contributes to depression-like behavior in mice	12
CircRNA-104718 promotes glioma malignancy through regulation of miR-218-5p/HMGB1 signalling pathway	12
Ligustilide ameliorates cognitive impairment via AMPK/SIRT1 pathway in vascular dementia rat	12
Circular RNA circ-ARFIP2 regulates proliferation, migration and invasion in human vascular smooth muscle cells via miR-338-3p-dependent modulation of KDR	12
Correction to: Morin hydrate attenuates chronic stress-induced memory impairment and degeneration of hippocampal subfields in mice: The role of oxidative, nitrergic and neuroinflammatory pathways	12
Review of neuropsychological outcomes in isolated methylmalonic acidemia: recommendations for assessing impact of treatments	12
A novel homozygous PIGO mutation associated with severe infantile epileptic encephalopathy, profound developmental delay and psychomotor retardation: structural and 3D modelling investigations and gen	12
Free–L-Cysteine improves corticosterone-induced behavioral deficits, oxidative stress and neurotransmission in rats	12
Coadministration of tianeptine alters behavioral parameters and levels of neurotrophins in a chronic model of Maple Syrup Urine disease	12
Network activity changes in the pathophysiology of Alzheimer’s disease: the role of aging and early entorhinal cortex dysfunction	12
Special Issue: Pathophysiology, diagnosis, and management of hepatic encephalopathy	12
LPS-induced impairment of Na+/K+-ATPase activity: ameliorative effect of tannic acid in mice	12
Exercise training ameliorates cognitive dysfunction in amyloid beta-injected rat model: possible mechanisms of Angiostatin/VEGF signaling	11
Sevoflurane inhibits the malignant phenotypes of glioma through regulating miR-146b-5p/NFIB axis	11
Circular RNA circSLC8A1 inhibits the proliferation and invasion of glioma cells through targeting the miR-214-5p/CDC27 axis	11
Ginkgolide B inactivates the NLRP3 inflammasome by promoting autophagic degradation to improve learning and memory impairment in Alzheimer’s disease	11
Necrostatin-1S mitigates type-2 diabetes-associated cognitive decrement and lipotoxicity-induced neuro-microglia changes through p-RIPK-RIPK3-p-MLKL axis	11
Identification of methylation markers for diagnosis of autism spectrum disorder	11
Correction to: Administration of growth hormone ameliorates adverse effects of total sleep deprivation	11
Correction to: Laterality and sex differences in the expression of brain-derived neurotrophic factor in developing rat hippocampus	11
CircRNA circ_POSTN promotes the malignancy of glioma by regulating the miR-433-3p/SPARC axis	11
Paeoniflorin ameliorates cognitive impairment in Parkinson’s disease via JNK/p53 signaling	11
Genistein suppresses microglial activation and inhibits apoptosis in different brain regions of hypoxia-exposed mice model of amnesia	11
Sevoflurane represses the progression of glioma by the regulation of circ_0037655/miR-130a-5p/RPN2 axis	11
Assessing the Evolution of Intracranial Hematomas by using Animal Models: A Review of the Progress and the Challenges	11
Long non-coding RNA UCA1 regulates MPP+-induced neuronal damage through the miR-671-5p/KPNA4 pathway in SK-N-SH cells	11
3-Methyladenine ameliorates surgery-induced anxiety-like behaviors in aged mice by inhibiting autophagy-induced excessive oxidative stress	11
Toxoplasmosis: Targeting neurotransmitter systems in psychiatric disorders	11
Experimental evidence of tyrosine neurotoxicity: focus on mitochondrial dysfunction	11
MiR-487b suppressed inflammation and neuronal apoptosis in spinal cord injury by targeted Ifitm3	11
High-fat diet induced hippocampal CREB dysfunction, cognitive impairment and depression-like behaviors via downregulation of interleukin-2 in the mice	11
A network pharmacology study with molecular docking to investigate the possibility of licorice against posttraumatic stress disorder	11
Circ_0057583 facilitates brain microvascular endothelial cell injury through modulating miR-204-5p/NR4A1 axis	11
α7 nicotinic acetylcholine receptor agonist improved brain injury and impaired glucose metabolism in a rat model of ischemic stroke	10
Discrepancy of synaptic and microtubular protein phosphorylation in the hippocampus of APP/PS1 and MAPT×P301S transgenic mice at the early stage of Alzheimer’s disease	10
Clinical, neuroradiological and genetic findings in a cohort of patients with multiple Cerebral Cavernous Malformations	10
Aspirin attenuates morphine antinociceptive tolerance in rats with diabetic neuropathy by inhibiting apoptosis in the dorsal root ganglia	10
Albumin therapy for hepatic encephalopathy: current evidence and controversies	10
High serum complement component C4 as a unique predictor of unfavorable outcomes in diabetic stroke	10
Correction to: D-beta-hydroxybutyrate protects against microglial activation in lipopolysaccharide-treated mice and BV-2 cells	10
Palatable high-fat diet intake influences mnemonic and emotional aspects in female rats in an estrous cycle-dependent manner	10
Promising biomarkers and therapeutic targets for the management of Parkinson's disease: recent advancements and contemporary research	10
Ferrous sulfate reverses cerebral metabolic abnormality induced by minimal hepatic encephalopathy	10
Silencing of the circ-Arhgap5 RNA protects neuronal PC12 cells against injury and depends on the miR-29a-3p/Rock1 axis	10
Selective in vitro anticancer effect of blueberry extract (Vaccinium virgatum) against C6 rat glioma: exploring their redox status	10
Administration of Selenium Nanoparticles Reverses Streptozotocin-Induced Neurotoxicity in the male rats	10
Recent advances in pre-clinical diagnosis of Alzheimer’s disease	10
Protective effect of calpain inhibitors against manganese-induced toxicity in rats	10
Deterioration of visual quality and acuity as the first sign of ceroid lipofuscinosis type 3 (CLN3), a rare neurometabolic disease	10
Mucopolysaccharidosis type IIIC in chinese mainland: clinical and molecular characteristics of ten patients and report of six novel variants in the HGSNAT gene	10
Cannabidiol promotes neurogenesis in the dentate gyrus during an abstinence period in rats following chronic exposure to methamphetamine	10

Pathology-supported genetic testing as a method for disability prevention in multiple sclerosis (MS). Part I. Targeting a metabolic model rather than autoimmunity	10
Altered glucose metabolism and its association with carbonic anhydrase 8 in Machado-Joseph Disease	10
Detection of structural and conformational changes in ALS-causing mutant profilin-1 with hydrogen/deuterium exchange mass spectrometry and bioinformatics techniques	10
Plasma phosphorylated-tau181 levels reflect white matter microstructural changes across Alzheimer’s disease progression.	10
Hepatic glycogen participates in the regulation of hypothalamic pAkt/Akt ratio in high-sugar/high-fat diet-induced obesity	10