Toxicology in Vitro

Papers
(The median citation count of Toxicology in Vitro is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)
ArticleCitations
Editorial Board60
Evaluation of an imaging-based in vitro screening platform for estrogenic activity with OECD reference chemicals47
In vitro safety evaluation of sunscreen formulation from nanostructured lipid carriers using human cells and skin model43
Emerging trends in immunotoxin targeting cancer stem cells40
Mechanism for inhibition of cytotoxicity of Shiga toxin by luteolin34
Prediction of acute oral toxicity using the Hansen solubility parameter31
Evaluation of in vitro cornea models for quantifying destructive effects of chemicals31
Protective effects of silibinin against ethanol- or acetaldehyde-caused damage in liver cell lines involve the repression of mitochondrial fission31
Metformin and buparlisib synergistically induce apoptosis of non-small lung cancer (NSCLC) cells via Akt/FoxO3a/Puma axis30
Organochlorine pesticides disrupt T helper cell regulation and reduce IL-2 and IFN-γ favoring infection and production of autoantibodies among pemphigus patients30
Minimum information for studies of extracellular vesicles (MISEV) as toolbox for rigorous, reproducible and homogeneous studies on extracellular vesicles29
Essential oil from Ocimum carnosum induces ROS mediated mitochondrial dysfunction and intrinsic apoptosis in HL-60 cells29
Evaluation of neurotoxicity for pesticide-related compounds in human iPS cell-derived neurons using microelectrode array29
Construction of an in vitro simulated one compartment extravascular administration model and its comparison with classic in vitro administration model in copper chloride induced HepG2 cell death29
The selected epigenetic effects of phthalates: DBP, BBP and their metabolites: MBP, MBzP on human peripheral blood mononuclear cells (In Vitro)29
Increased effects of 2,5-dimethylcelecoxib on sensitivity of hepatocellular carcinoma cells to sorafenib via CYP3A5 expression and activation of AMPK28
Using cimetidine to mitigate cisplatin-induced ototoxicity27
Dinaciclib inhibits the growth of acute myeloid leukemia cells through either cell cycle-related or ERK1/STAT3/MYC pathways26
The evaluation of anticancer activity by synthesizing 5FU loaded albumin nanoparticles by exposure to UV light25
Fit-for-purpose characterization of air-liquid-interface (ALI) in vitro exposure systems for e-vapor aerosol25
Multidirectional anti-melanoma effect of galactolipids (MGDG-1 and DGDG-1) from Impatiens parviflora DC. and their synergy with doxorubicin25
Corrigendum to ‘Fructose-palmitate based high calorie induce steatosis in HepG2 cells via mitochondrial dysfunction: An in vitro approach’ [Toxicology in Vitro 68 (2020) 104952]24
Machine learning predictive classification models for the carcinogenic activity of activated metabolites derived from aromatic amines and nitroaromatics22
Cytotoxicity reduction by O-nicotinoylation of antiviral 6-benzylaminopurine ribonucleosides22
Comparative analyses of transcriptome sequencing and carcinogenic exposure toxicity of nicotine and 6-methyl nicotine in human bronchial epithelial cells21
An in vitro nerve agent brain poisoning transwell model for convenient and accurate antidote evaluation21
Development of a human FaFg prediction system for polyphenols using human induced pluripotent stem cell-derived small intestinal epithelial cells21
In vitro genotoxic and antigenotoxic effects of an exopolysaccharide isolated from Lactobacillus salivarius KC27L21
A simple method to evaluate the toxic effects of Prorocentrum lima extracts to fish (sea bass) kidney cells21
Antimycin A-induced mitochondrial dysfunction is consistent with impaired insulin signaling in cultured skeletal muscle cells20
Phloretin exhibits potential food-drug interactions by inhibiting human UDP-glucuronosyltransferases in vitro20
In-house performance assessment of 3D QobuR-Reconstructed Human Cornea-Like Epithelium (RhCE) for the evaluation of eye hazard20
Benzo[b]fluoranthene (B[b]F) affects apoptosis, oxidative stress, mitochondrial membrane potential and expressions of blood-brain barrier markers in microvascular endothelial cells20
Genotoxicity of putrescine and its effects on gene expression in HepG2 cell line19
Silencing Nrf2 in cisplatin resistant non-small cell lung cancer cells augments sensitivity towards EGFR inhibitor19
The effect of endocrine disrupting chemicals on the vitronectin-receptor (integrin αvβ3)-mediated cell adhesion of human umbilical vein endothelial cells19
Editorial Board19
Berberine-loaded engineered nanoparticles attenuate TGF-β-induced remodelling in human bronchial epithelial cells18
Nimbolide-encapsulated PLGA nanoparticles induces Mesenchymal-to-Epithelial Transition by dual inhibition of AKT and mTOR in pancreatic cancer stem cells18
Streptomycin generates oxidative stress in melanin-producing cells: In vitro study with EPR spectroscopy evidence18
Sens-ocular model: Cell-based assay to evaluate eye stinging potential of chemicals and baby cosmetic formulations.18
Influence of bile acids on the cytotoxicity of chemicals in cultivated human hepatocytes18
Can TK-TD modelling bridge the gap between in vitro and in vivo mammalian toxicity data?18
Assessment of the utility of the novel Phenion® full thickness human skin model for detecting the skin irritation potential of antimicrobial cleaning products17
Unveiling the intricacies of BPA and BPS: comprehensive insights into its toxic effects using a cutting-edge microphysiological system17
Analysis of reproducibility and robustness of OrganoPlate® 2-lane 96, a liver microphysiological system for studies of pharmacokinetics and toxicological assessment of drugs17
Antibiotics reduce intestinal bile acid reuptake in an in vitro model system17
Physodic acid sensitizes LNCaP prostate cancer cells to TRAIL-induced apoptosis17
Anti-migratory and cytotoxic effect of indole derivative in C6 glioma cells17
TGF-β1/SMADs signaling involved in alleviating inflammation induced by nanoparticulate titanium dioxide in BV2 cells16
Editorial Board16
Sinapic acid alleviates glutamate-induced excitotoxicity by inhibiting neuroinflammation and endoplasmic reticulum stress pathway in C6 glioma cells16
Development of natural cosmetic emulsion using the by-product of Lecythis pisonis seed16
Mitochondrial division inhibitor (mdivi-1) inhibits proliferation and epithelial-mesenchymal transition via the NF-κB pathway in thyroid cancer cells16
The importance of metrological tools to implementation of alternative method OECD TG 42815
Influence of alkylthio and arylthio derivatives of tert-butylquinone on the induction of DNA damage in a human hepatocellular carcinoma cell line (HepG2)15
Photodynamic therapy with curcumin and near-infrared radiation as an antitumor strategy to glioblastoma cells15
Editorial Board15
Overdose with the anesthetic propofol causes hematological cytotoxicity and immune cell alteration in an experimental ex vivo whole blood culture model15
Effects of radical scavengers for reactive oxygen species on vitamin K-induced phototoxicity under UVA irradiation15
In vitro immune and redox response induced by cationic cellulose-based nanomaterials15
Curcumin induces mitophagy by promoting mitochondrial succinate dehydrogenase activity and sensitizes human papillary thyroid carcinoma BCPAP cells to radioiodine treatment14
Species differences in microsomal metabolism of hydroxychloroquine14
Developmental toxicity testing of unsubstituted and methylated 4- and 5-ring polycyclic aromatic hydrocarbons using the zebrafish embryotoxicity test14
Calcium channel blockers lercanidipine and amlodipine inhibit YY1/ERK/TGF-β mediated transcription and sensitize the gastric cancer cells to doxorubicin14
Studying the intracellular bile acid concentration and toxicity in drug-induced cholestasis: Comprehensive LC-MS/MS analysis with human liver slices14
Association between drug-induced heart failure and CYP1A1, CYP1B1, and CYP3A4 inhibition: Utility of cytochrome P450 inhibition assay for evaluating cardiotoxicity of drug candidates14
Enhanced cell death effects of MAP kinase inhibitors in propyl gallate-treated lung cancer cells are related to increased ROS levels and GSH depletion14
Selective inhibition of HDAC6 by N-acylhydrazone derivative reduces the proliferation and induces senescence in carcinoma hepatocellular cells14
Characterization of prodigiosin pigment by Serratia marcescens and the evaluation of its bioactivities14
Characterization of elements, PAHs, AhR-activity and pro-inflammatory responses of road tunnel-derived particulate matter in human hepatocyte-like and bronchial epithelial cells14
In vitro inhibitory effects of selumetinib on activity of human UDP-glucuronosyltransferases and prediction of in vivo drug-drug interactions14
Toxicological and microbiological characterization of cow stable dust13
Butein induces intrinsic pathway of apoptosis, vimentin proteolysis, and inhibition of cancer stem cell population in a human papillary thyroid cancer cell line13
Silibinin inhibits ethanol- or acetaldehyde-induced ferroptosis in liver cell lines13
ESTIV 2022: Key enabling non-animal technologies for research, education and testing13
Organic ultraviolet filters regulate hyaluronan metabolism in human epidermal keratinocytes through the phosphatidylinositol 3-kinase pathway13
Editorial Board13
TNF-α and MMPs mediated mucus hypersecretion induced by cigarette smoke: An in vitro study13
Optimization of in vitro culture of honeybee nervous tissue for pesticide risk assessment13
Differential comparison of genotoxic effects of aristolochic acid I and II in human cells by the mass spectroscopic quantification of γ-H2AX13
Corrigendum to “Zearalenone causes embryotoxicity and induces oxidative stress and apoptosis in differentiated human embryonic stem cells” [Toxicology in Vitro 54 (2019) 243–250]13
Comprehensive studies on the biological activities of human metastatic (MDA-MB-231) and non-metastatic (MCF-7) breast cancer cell lines, directly or combinedly treated using non-thermal plasma-based a13
The numerical probability of carcinogenicity to humans of some antimicrobials: Nitro-monoaromatics (including 5-nitrofurans and 5-nitroimidazoles), quinoxaline-1,4-dioxides (including carbadox), and c12
Involvement of Sirt1-FoxO3a-Bnip3 axis and autophagy mediated mitochondrial turnover in according protection to hyperglycemic NRK-52E cells by Berberine12
Nonylphenol reduced the number of haploids in in vitro spermatogenesis of the endangered cyprinid Gnathopogon caerulescens12
Fragrances as a trigger of immune responses in different environments12
Effects of antimicrobial metal nanoparticles on characteristics and function properties of mouse mesenchymal stem cells12
The effects of Acyclovir administration to NCI-H1975 non-small cell lung cancer cells12
In vitro assessment of cytotoxicity of spent fluid catalytic cracking refinery catalysts on cell lines and identification of critical toxic metals12
The effect of airborne Palladium nanoparticles on human lung cells, endothelium and blood – A combinatory approach using three in vitro models12
Cigarette smoke extract decreases human bone marrow mesenchymal stromal cell adipogenic differentiation12
Corrigendum to ‘Inflammatory and tumorigenic effects of environmental pollutants found in particulate matter on lung epithelial cells’ [Toxicol In Vitro 59 (2019) 300–311]11
Editorial Board11
Evaluating the QileX-RhE skin corrosion test for chemical subcategorization in accordance with OECD TG 43111
Stable expression of the human dopamine transporter in N27 cells as an in vitro model for dopamine cell trafficking and metabolism11
4-hydroxybenzophenone exposure inhibits mouse hippocampal neural stem cell proliferation in vitro by upregulating Cxcl111
4-O-methylascochlorin-stimulated HIF-1α expression induces the epithelial mesenchymal transition and cell survival in breast cancer cells11
Stent conditioned media for in vitro evaluation of hydrophobic stent coatings11
Intragenic antimicrobial peptide Hs02 toxicity against leukemia cell lines is associated with increased expression of select pyroptotic components11
Effects of culture media on gene expression in reconstructed human epidermis and THP-1 monocytes for skin sensitization evaluation in co-culture systems11
In vitro toxicity of two functionalized reduced graphene oxide materials with potential application in food packaging11
DMC triggers MDA-MB-231 cells apoptosis via inhibiting protective autophagy and PI3K/AKT/mTOR pathway by enhancing ROS level11
Frankenstein's followers. Maintenance of human cells outside the body. Issue 111
Influence of cellular redox environment on aryl hydrocarbon receptor ligands induced melanogenesis11
Benzo[a]pyrene inhibits myoblast differentiation through downregulating the Hsp70-MK2-p38MAPK complex11
Mesoporous nanosilica: A thromboprotective nanomaterial for biomedical applications11
Transcription Factor yin-Yang 1 augments nucleoporin 93 oncogene activity and modulates bladder Cancer malignancy11
Risk assessment of chlorophenols (CPs) exposure in vitro:Inhibition of sulfotransferases (SULTs) activity10
Strategies for the evaluation of the eye irritation potential of different types of surfactants and silicones used in cosmetic products10
Potential risk of drug-drug interactions of ponatinib via inhibition against human UDP-glucuronosyltransferases10
Melatonin prevents blood-retinal barrier breakdown and mitochondrial dysfunction in high glucose and hypoxia-induced in vitro diabetic macular edema model10
Pracaxi oil affects xenobiotic metabolisms, cellular proliferation, and oxidative stress without cytotogenotoxic effects in HepG2/C3A cells10
Exosome proteomics study of the effects of traditional cigarettes and electronic cigarettes on human bronchial epithelial cells10
In vitro human skin absorption of ethyl salicylate, pentyl salicylate, and (Z)-3-hexenyl salicylate from topical formulations: Effects on permeation and distribution10
Differential cytotoxic activity of pharmacological inhibitors of IGF1R-related pathways in JAK2V617F driven cells10
Mictlan-D3: A novel medium sized RGD-Disintegrin obtained from Crotalus mictlantecuhtli venom, in vitro tested against human breast Cancer and endothelial cells10
The SNHG10-miR-495-3p-PTEN axis is involved in sevoflurane-mediated protective effects in cardiomyocytes against hypoxia/reoxygenation injury10
How to use an in vitro approach to characterize the toxicity of airborne compounds10
Risperidone-induced bioenergetic disruption in the isolated human peripheral blood monocytes10
Everolimus prevents doxorubicin-induced apoptosis in H9c2 cardiomyocytes but not in MCF-7 cancer cells: Cardioprotective roles of autophagy, mitophagy, and AKT9
N-acetyl-L-cysteine attenuated the toxicity of ZIF-8 on EA.hy926 endothelial cells by wnt/β-catenin pathway9
In silico modelling of acute toxicity of 1, 2, 4-triazole antifungal agents towards zebrafish (Danio rerio) embryos: Application of the Small Dataset Modeller tool9
Concentration-dependent effects of chlorpyrifos oxon on peroxisome proliferator-activated receptor signaling in MCF-7 cells9
Effects of di-(2-ethylhexyl) phthalate and its metabolites on transcriptional activity via human nuclear receptors and gene expression in HepaRG cells9
E-cigarette fluids and aerosol residues cause oxidative stress and an inflammatory response in human keratinocytes and 3D skin models9
Effect of serotonin 7 receptors and transcript variants on RIN-5F pancreatic beta cell line9
(-)-Epigallocatechin gallate as an inhibitor of hemoglobin-catalyzed lipid oxidation: molecular mechanism of action and nutritional application9
Washing with buffered vitamin C after corrosive chemical (sodium hypochlorite) exposure reduces ocular depth of injury9
Transdermal permeation of inorganic cerium salts in intact human skin9
Editorial Board9
Acrylamide-induced damage to postsynaptic plasticity is CYP2E1 dependent in an SH-SY5Y co-culture system9
Acute cytotoxicity, genotoxicity, and apoptosis induced by petroleum VOC emissions in A549 cell line9
Polystyrene nanoparticles incorporate into the endoplasmic reticulum and disturb translation during meiotic maturation in mouse oocytes9
The role of efflux transporters in cytotoxicity and intracellular concentration of chlorpyrifos and chlorpyrifos oxon in human cell lines9
Investigating the mechanisms of action of thyroid disruptors: A multimodal approach that integrates in vitro and metabolomic analysis9
In vitro metabolism of lidocaine in subcellular post-mitochondrial fractions and precision cut slices from cattle liver9
Bufadienolides from the Bufo viridis toad venom exert cytotoxic effects on cancer cells by inducing cell apoptosis and cell cycle arrest9
Biological effects of combustion-derived particles from different biomass sources on human bronchial epithelial cells9
Identification of the function and regulatory network of circ_009773 in DNA damage induced by nanoparticles of neodymium oxide9
Study on percutaneous penetration of representative cosmetic ingredients in a baby wipe product in an in vitro diaper rash skin model9
In vitro eye irritation testing models may play pivotal role in effort to pursue mild baby cleansers9
Osthole protects H9c2 cardiomyocytes against trastuzumab-induced damage by enhancing autophagy through the p38MAPK/mTOR signaling pathway9
Comparative evaluation of HET-CAM and ICE methods for objective assessment of ocular irritation caused by selected pesticide products9
Toxicity of New Psychoactive Substance (NPS): Threo-4-methylmethylphenidate (4-Mmph) – Prediction of toxicity using in silico methods8
Risk assessment of the inhibition of hydroxygenkwanin on human and rat cytochrome P450 by cocktail method8
Evaluation of toxicological aspects of three new benzoxazole compounds with sunscreen photophysical properties using in silico and in vitro methods8
Effects of methylation of arginine residue 83 on the enzymatic activity of human arsenic (+3 oxidation state) methyltransferase8
A battery of in silico models application for pesticides exerting reproductive health effects: Assessment of performance and prioritization of mechanistic studies8
Cytotoxicity of ZnO nanoparticles in human melanocyte cells in the presence or absence of UV radiation: A preliminary comparative study with TiO2 nanoparticles8
High-throughput assay for predicting diarrhea risk using a 2D human intestinal stem cell-derived model8
6:2 fluorotelomer sulfonate as a safer alternative to PFOS: Comparative cytotoxicity and oxidative stress mechanisms in pancreatic β-cells (INS-1 model)8
Delta-9 tetrahydrocannabinol (THC) effects on the cortisol stress response in bovine granulosa cells8
Perfluorooctanoic acid inhibits cell proliferation through mitochondrial damage8
In vitro toxicological evaluation of a tobacco heating product THP COO and 3R4F research reference cigarette on human lung cancer cells8
Time dependent impact of copper oxide nanomaterials on the expression of genes associated with oxidative stress, metal binding, inflammation and mucus secretion in single and co-culture intestinal in 8
Long-term in vitro exposure of human granulosa cells to the mixture of endocrine disrupting chemicals found in human follicular fluid disrupts steroidogenesis7
Transcriptomic changes and mitochondrial toxicity in response to acute and repeat dose treatment with brequinar in human liver and kidney in vitro models7
Next generation risk assessment (NGRA): Bridging in vitro points-of-departure to human safety assessment using physiologically-based kinetic (PBK) modelling – A case study of doxorubicin with dose met7
The Alarming Consequences of Workforce Reductions at the FDA, EPA, NIH and CDC in the United States7
STF-083010 an inhibitor of IRE1α endonuclease activity affects mitochondrial respiration and generation of mitochondrial membrane potential7
Pre-validation of a Calu-3 epithelium cytotoxicity assay for predicting acute inhalation toxicity of chemicals7
In vitro biocompatibility and wound healing properties of latex proteins dressing7
Telomere loss is accompanied by decreased pool of shelterin proteins TRF2 and RAP1, elevated levels of TERRA and enhanced glycolysis in imatinib-resistant CML cells7
Editorial Board7
Normalization of organ-on-a-Chip samples for mass spectrometry based proteomics and metabolomics via Dansylation-based assay7
Chemometric modeling of acute toxicity of diverse aromatic compounds against Rana japonica7
Busulfan-induced hepatic sinusoidal endothelial cell injury: Modulatory role of pirfenidone for therapeutic purposes7
Mitochondria oxidative stress mediated nicotine-promoted activation of pancreatic stellate cells by regulating mitochondrial dynamics7
The mechanism of thrombocytopenia caused by cholesterol-conjugated antisense oligonucleotides7
Blocking Autophagy by the Two-Pore Channels Antagonist Tetrandrine Improves Sorafenib-Induced Death of Hepatocellular Carcinoma Cells7
Antifungal climbazole alters androgenic pathways in mammalian cells7
Mettl3-mediated transcriptome-wide m6A methylation induced by cigarette smoking in human bronchial epithelial cells7
A novel O2- (2,4-dinitrophenyl) diazeniumdiolate inhibits hepatocellular carcinoma migration, invasion, and EMT through the Wnt/β-catenin pathway7
Differential DNA damage response and cell fate in human lung cells after exposure to genotoxic compounds7
Application of ToxCast/Tox21 data for toxicity mechanism-based evaluation and prioritization of environmental chemicals: Perspective and limitations7
Lead inhibits the odontogenic differentiation potential of dental pulp stem cells by affecting WNT1/β-catenin signaling and related miRNAs expression7
m-Cresol,a pesticide intermediate, induces hepatotoxicity and behavioral abnormalities in zebrafish larvae through oxidative stress, apoptosis7
Hydroxylation markedly alters how the polychlorinated biphenyl (PCB) congener, PCB52, affects gene expression in human preadipocytes7
Dendritic cells activated by cimetidine induce Th1/Th17 polarization in vitro and in vivo7
Cell differentiation in the cardiac embryonic stem cell test (ESTc) is influenced by the oxygen tension in its underlying embryonic stem cell culture7
The impact of bisphenol AF on skeletal muscle function and differentiation in vitro7
Editorial Board6
Evaluation of toxicity of heated tobacco products aerosol and cigarette smoke to BEAS-2B cells based on 3D biomimetic chip model6
Cannabinoids and standardized cannabis extracts inhibit migration, invasion, and induce apoptosis in MCF-7 cells through FAK/MAPK/Akt/NF-κB signaling6
Discovery of potent antitubercular agents: Design, synthesis and biological evaluation of 4-(3-(4-substitutedpiperazin-1-yl)-quinoxalin-2-yl)-naphthalen-1-ol analogues6
Effect of long-term inorganic arsenic exposure on erythropoietin production in vitro6
METTL3 regulates FAM83D m6A modification to accelerate tumorigenesis of triple-negative breast cancer via the Wnt/β-catenin pathway6
Evaluation of the inhibitory effects of antigout drugs on human carboxylesterases in vitro6
Arsenic trioxide inhibits the response of primary human B cells to influenza virus A in vitro6
Development of 3D-QSAR models for predicting the activities of chemicals to stimulate muscle growth via β2-adrenoceptor6
Effects of chlorpyrifos on non-cholinergic toxicity endpoints in immortalized and primary rat hepatocytes under normal and hepatosteatotic conditions6
Establishment of a human induced pluripotent stem cell derived alveolar organoid for toxicity assessment6
Characterization of the intestinal transport mechanism of polystyrene microplastics (MPs) and the potential inhibitory effect of green tea extracts on MPs intestinal absorption6
Transcriptome sequencing reveals neurotoxicity in embryonic neural stem/progenitor cells under heat stress6
Corrigendum to “Exploring the combined impact of cisplatin and copper-cysteamine nanoparticles through Chemoradiation: An in-vitro study” [Toxicology in vitro 99 (2024) 105878].6
Multi-label classification and label dependence in in silico toxicity prediction6
Modeling the antioxidant properties of the eye reduces the false-positive rate of a nonanimal eye irritation test (OptiSafe)6
Counterions determine uptake and effects of aluminum in human intestinal and liver cells6
Proton pump inhibitors interfere with the anti-tumor potency of RC48ADC6
Suppression of lncRNA Snhg1 inhibits high glucose-induced inflammation and proliferation in mouse mesangial cells6
Curcumin-loaded emulsome nanoparticles induces apoptosis through p53 signaling pathway in pancreatic cancer cell line PANC-16
Interactions of oleanane pentacyclic triterpenoids with human organic anion transporting polypeptide 1B1 and 1B36
Transcriptome responses in polar cod (Boreogadus saida) liver slice culture exposed to benzo[a]pyrene and ethynylestradiol: insights into anti-estrogenic effects6
Scutellarin attenuates doxorubicin-induced oxidative stress, DNA damage, mitochondrial dysfunction, apoptosis and autophagy in H9c2 cells, cardiac fibroblasts and HUVECs6
Applications of Premature Chromosome Condensation technique for genetic analysis6
Editorial Board6
The use of in silico molecular modelling to screen potential estrogen mimics as part of medicines and agrochemicals development and product license applications.6
N-acetylcysteine protect inner hair cells from cisplatin by alleviated celluar oxidative stress and apoptosis6
Effect of curcumin on the embryotoxic effect of ethanol in a zebrafish model6
Effects of an environmentally relevant mixture of organochlorine pesticide compounds on adipogenesis and adipocyte function in an immortalized human adipocyte model6
Suitability of human HepaRG cells and liver spheroids as in vitro model to investigate the bioactivation of the organothiophosphate pesticide parathion6
Chemotherapeutic effect of baicalein/epirubicin combination against liver cell carcinoma in-vitro: Inducing apoptosis and autophagy6
Triphenyltin chloride exposure inhibits meiotic maturation of mouse oocytes by disrupting cytoskeleton assembly and cell cycle progression6
Cytotoxicity assay to assess eye irritation – A comparison with other methods and possible strategies for use6
miRNA-6515-5p regulates particulate matter-induced inflammatory responses by targeting CSF3 in human bronchial epithelial cells6
CircPDSS1 (hsa_circ_0017998) silencing induces ferroptosis in non-small-cell lung cancer cells by modulating the miR-137/SLC7A11/GPX4/GCLC axis6
Editorial Board5
Epigallocatechin gallate alleviates mono-2-ethylhexyl phthalate-induced male germ cell pyroptosis by inhibiting the ROS/mTOR/NLRP3 pathway5
Nicotinamide mononucleotide inhibits oxidative stress-induced damage in a SIRT1/NQO-1-dependent manner5
Comparative in vitro toxicological effects of water-soluble and insoluble components of atmospheric PM2.5 on human lung cells5
Grandiflorenic acid isolated from Sphagneticola trilobata against Trypanosoma cruzi: Toxicity, mechanisms of action and immunomodulation5
Gaining insight into genotoxicity with the comet assay in inhomogenoeous exposure scenarios: The effects of tritiated steel and cement particles on human lung cells in an inhalation perspective5
Akt and MAPK/ERK signaling regulate neurite extension in adult neural progenitor cells but do not directly mediate disruption of cytoskeletal structure and neurite dynamics by low-level silver nanopar5
Application of in vitro methods to evaluate the safety of baby care products5
Psidium guajava induces cytotoxicity in human malignant glioblastoma cell line: Role of reactive oxygen species5
The correlation of haptenation of gold nanoparticles and cysteine modified screen printed carbon electrode by impedance technique with local lymph node assay data5
Evaluation of a high-throughput H295R homogenous time resolved fluorescence assay for androgen and estrogen steroidogenesis screening5
In chemico sequential testing strategy for assessing the photoallegic potential5
Cell-based high-throughput screening for the evaluation of reactive metabolite formation potential5
PBA alleviates cadmium-induced mouse spermatogonia apoptosis by suppressing endoplasmic reticulum stress5
New insights into the cytotoxic effects of Thymus vulgaris essential oil on the human triple-negative breast cancer cell line MDA-MB-2315
Oxidative Stress, Lysosomal Permeability, and Mitochondrial-Derived Vesicles Induced in NL-20 Human Bronchial Cells Exposed to Benzo[ghi]Perylene5
Silver nanoparticles induce formation of multi-protein aggregates that contain cadherin but do not colocalize with nanoparticles5
E-cigarettes induce toxicity comparable to tobacco cigarettes in airway epithelium from patients with COPD5
PBTK modeled perfluoroalkyl acid kinetics in zebrafish eleutheroembryos suggests impacts on bioconcentrations by chorion porosity dynamics5
In vitro neurotoxic potential of emerging flame retardants on neuroblastoma cells in an acute exposure scenario5
Modulation of adipogenesis and lipogenesis by indomethacin and pantoprazole5
Propofol inhibits proliferation and migration of glioma cells by up-regulating lncRNA GAS55
Vincristine promotes differential levels of apoptosis, mitotic catastrophe, and senescence depending on the genetic background of glioblastoma cells5
Editorial Board5
Anticancer effect of paroxetine and amitriptyline on HT29 and A549 cell lines5
High-content analysis of testicular toxicity of BPA and its selected analogs in mouse spermatogonial, Sertoli cells, and Leydig cells revealed BPAF induced unique multinucleation phenotype associated 5
Selected phytocannabinoids inhibit SN-38- and cytokine-evoked increases in epithelial permeability and improve intestinal barrier function in vitro5
Heat shock protein HSPA8 impedes hemin-induced cellular-toxicity in liver5
Circ_0005758 impedes gastric cancer progression through miR-1229-3p/GCNT4 feedback loop5
Nickel nanoparticles affect the migration and invasion of HTR-8/SVneo cells by downregulating MMP2 through the PI3K/AKT pathway5
Prediction of skin sensitization using machine learning5
Predicting the skin sensitizing potential of pesticides using Pred-skin 3.0–A web-based prediction tool5
Evaluating the combined and individual cytotoxic effect of beauvericin, enniatin B and ochratoxin a on breast cancer cells, leukemia cells, and fresh peripheral blood mononuclear cells5
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