Toxicology in Vitro

Article	Citations
Editorial Board	59
Evaluation of an imaging-based in vitro screening platform for estrogenic activity with OECD reference chemicals	47
In vitro safety evaluation of sunscreen formulation from nanostructured lipid carriers using human cells and skin model	40
Using cimetidine to mitigate cisplatin-induced ototoxicity	38
Essential oil from Ocimum carnosum induces ROS mediated mitochondrial dysfunction and intrinsic apoptosis in HL-60 cells	33
Mechanism for inhibition of cytotoxicity of Shiga toxin by luteolin	30
Evaluation of in vitro cornea models for quantifying destructive effects of chemicals	30
Emerging trends in immunotoxin targeting cancer stem cells	30
Protective effects of silibinin against ethanol- or acetaldehyde-caused damage in liver cell lines involve the repression of mitochondrial fission	30
Prediction of acute oral toxicity using the Hansen solubility parameter	29
Evaluation of neurotoxicity for pesticide-related compounds in human iPS cell-derived neurons using microelectrode array	29
Metformin and buparlisib synergistically induce apoptosis of non-small lung cancer (NSCLC) cells via Akt/FoxO3a/Puma axis	28
Organochlorine pesticides disrupt T helper cell regulation and reduce IL-2 and IFN-γ favoring infection and production of autoantibodies among pemphigus patients	28
Construction of an in vitro simulated one compartment extravascular administration model and its comparison with classic in vitro administration model in copper chloride induced HepG2 cell death	28
Minimum information for studies of extracellular vesicles (MISEV) as toolbox for rigorous, reproducible and homogeneous studies on extracellular vesicles	27
The selected epigenetic effects of phthalates: DBP, BBP and their metabolites: MBP, MBzP on human peripheral blood mononuclear cells (In Vitro)	26
Increased effects of 2,5-dimethylcelecoxib on sensitivity of hepatocellular carcinoma cells to sorafenib via CYP3A5 expression and activation of AMPK	26
Dinaciclib inhibits the growth of acute myeloid leukemia cells through either cell cycle-related or ERK1/STAT3/MYC pathways	26
Fit-for-purpose characterization of air-liquid-interface (ALI) in vitro exposure systems for e-vapor aerosol	25
The evaluation of anticancer activity by synthesizing 5FU loaded albumin nanoparticles by exposure to UV light	25
Multidirectional anti-melanoma effect of galactolipids (MGDG-1 and DGDG-1) from Impatiens parviflora DC. and their synergy with doxorubicin	23
Corrigendum to ‘Fructose-palmitate based high calorie induce steatosis in HepG2 cells via mitochondrial dysfunction: An in vitro approach’ [Toxicology in Vitro 68 (2020) 104952]	23
Machine learning predictive classification models for the carcinogenic activity of activated metabolites derived from aromatic amines and nitroaromatics	22
Antimycin A-induced mitochondrial dysfunction is consistent with impaired insulin signaling in cultured skeletal muscle cells	22
Cytotoxicity reduction by O-nicotinoylation of antiviral 6-benzylaminopurine ribonucleosides	21

Benzo[b]fluoranthene (B[b]F) affects apoptosis, oxidative stress, mitochondrial membrane potential and expressions of blood-brain barrier markers in microvascular endothelial cells	21
An in vitro nerve agent brain poisoning transwell model for convenient and accurate antidote evaluation	20
Development of a human FaFg prediction system for polyphenols using human induced pluripotent stem cell-derived small intestinal epithelial cells	20
In vitro genotoxic and antigenotoxic effects of an exopolysaccharide isolated from Lactobacillus salivarius KC27L	20
A simple method to evaluate the toxic effects of Prorocentrum lima extracts to fish (sea bass) kidney cells	20
Phloretin exhibits potential food-drug interactions by inhibiting human UDP-glucuronosyltransferases in vitro	19
In-house performance assessment of 3D QobuR-Reconstructed Human Cornea-Like Epithelium (RhCE) for the evaluation of eye hazard	19
Comparative analyses of transcriptome sequencing and carcinogenic exposure toxicity of nicotine and 6-methyl nicotine in human bronchial epithelial cells	19
Genotoxicity of putrescine and its effects on gene expression in HepG2 cell line	19
The effect of endocrine disrupting chemicals on the vitronectin-receptor (integrin αvβ3)-mediated cell adhesion of human umbilical vein endothelial cells	18
Can TK-TD modelling bridge the gap between in vitro and in vivo mammalian toxicity data?	18
Editorial Board	18
Silencing Nrf2 in cisplatin resistant non-small cell lung cancer cells augments sensitivity towards EGFR inhibitor	18
TGF-β1/SMADs signaling involved in alleviating inflammation induced by nanoparticulate titanium dioxide in BV2 cells	18
Assessment of the utility of the novel Phenion® full thickness human skin model for detecting the skin irritation potential of antimicrobial cleaning products	17
Nimbolide-encapsulated PLGA nanoparticles induces Mesenchymal-to-Epithelial Transition by dual inhibition of AKT and mTOR in pancreatic cancer stem cells	17
Anti-migratory and cytotoxic effect of indole derivative in C6 glioma cells	17
Mitochondrial division inhibitor (mdivi-1) inhibits proliferation and epithelial-mesenchymal transition via the NF-κB pathway in thyroid cancer cells	17
Influence of bile acids on the cytotoxicity of chemicals in cultivated human hepatocytes	17
Sens-ocular model: Cell-based assay to evaluate eye stinging potential of chemicals and baby cosmetic formulations.	17
Physodic acid sensitizes LNCaP prostate cancer cells to TRAIL-induced apoptosis	17
Analysis of reproducibility and robustness of OrganoPlate® 2-lane 96, a liver microphysiological system for studies of pharmacokinetics and toxicological assessment of drugs	17
Unveiling the intricacies of BPA and BPS: comprehensive insights into its toxic effects using a cutting-edge microphysiological system	16
Streptomycin generates oxidative stress in melanin-producing cells: In vitro study with EPR spectroscopy evidence	16
Editorial Board	16
Berberine-loaded engineered nanoparticles attenuate TGF-β-induced remodelling in human bronchial epithelial cells	16
Development of natural cosmetic emulsion using the by-product of Lecythis pisonis seed	16
Sinapic acid alleviates glutamate-induced excitotoxicity by inhibiting neuroinflammation and endoplasmic reticulum stress pathway in C6 glioma cells	16
Influence of alkylthio and arylthio derivatives of tert-butylquinone on the induction of DNA damage in a human hepatocellular carcinoma cell line (HepG2)	15
Editorial Board	15
Overdose with the anesthetic propofol causes hematological cytotoxicity and immune cell alteration in an experimental ex vivo whole blood culture model	15
Effects of radical scavengers for reactive oxygen species on vitamin K-induced phototoxicity under UVA irradiation	15
In vitro immune and redox response induced by cationic cellulose-based nanomaterials	15
The importance of metrological tools to implementation of alternative method OECD TG 428	15
Photodynamic therapy with curcumin and near-infrared radiation as an antitumor strategy to glioblastoma cells	15
In vitro inhibitory effects of selumetinib on activity of human UDP-glucuronosyltransferases and prediction of in vivo drug-drug interactions	15
Studying the intracellular bile acid concentration and toxicity in drug-induced cholestasis: Comprehensive LC-MS/MS analysis with human liver slices	14
Selective inhibition of HDAC6 by N-acylhydrazone derivative reduces the proliferation and induces senescence in carcinoma hepatocellular cells	14
ESTIV 2022: Key enabling non-animal technologies for research, education and testing	14
Characterization of prodigiosin pigment by Serratia marcescens and the evaluation of its bioactivities	14
Curcumin induces mitophagy by promoting mitochondrial succinate dehydrogenase activity and sensitizes human papillary thyroid carcinoma BCPAP cells to radioiodine treatment	14
Developmental toxicity testing of unsubstituted and methylated 4- and 5-ring polycyclic aromatic hydrocarbons using the zebrafish embryotoxicity test	14
Enhanced cell death effects of MAP kinase inhibitors in propyl gallate-treated lung cancer cells are related to increased ROS levels and GSH depletion	14
Characterization of elements, PAHs, AhR-activity and pro-inflammatory responses of road tunnel-derived particulate matter in human hepatocyte-like and bronchial epithelial cells	14
Calcium channel blockers lercanidipine and amlodipine inhibit YY1/ERK/TGF-β mediated transcription and sensitize the gastric cancer cells to doxorubicin	14
Editorial Board	13
Organic ultraviolet filters regulate hyaluronan metabolism in human epidermal keratinocytes through the phosphatidylinositol 3-kinase pathway	13
Optimization of in vitro culture of honeybee nervous tissue for pesticide risk assessment	13
Butein induces intrinsic pathway of apoptosis, vimentin proteolysis, and inhibition of cancer stem cell population in a human papillary thyroid cancer cell line	13
Comprehensive studies on the biological activities of human metastatic (MDA-MB-231) and non-metastatic (MCF-7) breast cancer cell lines, directly or combinedly treated using non-thermal plasma-based a	13

In vitro assessment of cytotoxicity of spent fluid catalytic cracking refinery catalysts on cell lines and identification of critical toxic metals	13
Differential comparison of genotoxic effects of aristolochic acid I and II in human cells by the mass spectroscopic quantification of γ-H2AX	13
Toxicological and microbiological characterization of cow stable dust	13
Corrigendum to “Zearalenone causes embryotoxicity and induces oxidative stress and apoptosis in differentiated human embryonic stem cells” [Toxicology in Vitro 54 (2019) 243–250]	12
Involvement of Sirt1-FoxO3a-Bnip3 axis and autophagy mediated mitochondrial turnover in according protection to hyperglycemic NRK-52E cells by Berberine	12
The effects of Acyclovir administration to NCI-H1975 non-small cell lung cancer cells	12
Cigarette smoke extract decreases human bone marrow mesenchymal stromal cell adipogenic differentiation	12
Fragrances as a trigger of immune responses in different environments	12
DMC triggers MDA-MB-231 cells apoptosis via inhibiting protective autophagy and PI3K/AKT/mTOR pathway by enhancing ROS level	12
Nonylphenol reduced the number of haploids in in vitro spermatogenesis of the endangered cyprinid Gnathopogon caerulescens	12
Effects of antimicrobial metal nanoparticles on characteristics and function properties of mouse mesenchymal stem cells	12
Silibinin inhibits ethanol- or acetaldehyde-induced ferroptosis in liver cell lines	11
4-O-methylascochlorin-stimulated HIF-1α expression induces the epithelial mesenchymal transition and cell survival in breast cancer cells	11
In vitro toxicity of two functionalized reduced graphene oxide materials with potential application in food packaging	11
Intragenic antimicrobial peptide Hs02 toxicity against leukemia cell lines is associated with increased expression of select pyroptotic components	11
TNF-α and MMPs mediated mucus hypersecretion induced by cigarette smoke: An in vitro study	11
The numerical probability of carcinogenicity to humans of some antimicrobials: Nitro-monoaromatics (including 5-nitrofurans and 5-nitroimidazoles), quinoxaline-1,4-dioxides (including carbadox), and c	11
Transcription Factor yin-Yang 1 augments nucleoporin 93 oncogene activity and modulates bladder Cancer malignancy	11
Frankenstein's followers. Maintenance of human cells outside the body. Issue 1	11
Influence of cellular redox environment on aryl hydrocarbon receptor ligands induced melanogenesis	11
The effect of airborne Palladium nanoparticles on human lung cells, endothelium and blood – A combinatory approach using three in vitro models	11
Corrigendum to ‘Inflammatory and tumorigenic effects of environmental pollutants found in particulate matter on lung epithelial cells’ [Toxicol In Vitro 59 (2019) 300–311]	11
Editorial Board	11
Stent conditioned media for in vitro evaluation of hydrophobic stent coatings	11
Evaluating the QileX-RhE skin corrosion test for chemical subcategorization in accordance with OECD TG 431	11
Differential cytotoxic activity of pharmacological inhibitors of IGF1R-related pathways in JAK2V617F driven cells	10
Acute cytotoxicity, genotoxicity, and apoptosis induced by petroleum VOC emissions in A549 cell line	10
Potential risk of drug-drug interactions of ponatinib via inhibition against human UDP-glucuronosyltransferases	10
Benzo[a]pyrene inhibits myoblast differentiation through downregulating the Hsp70-MK2-p38MAPK complex	10
Mesoporous nanosilica: A thromboprotective nanomaterial for biomedical applications	10
Mictlan-D3: A novel medium sized RGD-Disintegrin obtained from Crotalus mictlantecuhtli venom, in vitro tested against human breast Cancer and endothelial cells	10
Risperidone-induced bioenergetic disruption in the isolated human peripheral blood monocytes	10
Melatonin prevents blood-retinal barrier breakdown and mitochondrial dysfunction in high glucose and hypoxia-induced in vitro diabetic macular edema model	10
How to use an in vitro approach to characterize the toxicity of airborne compounds	10
4-hydroxybenzophenone exposure inhibits mouse hippocampal neural stem cell proliferation in vitro by upregulating Cxcl1	10
Stable expression of the human dopamine transporter in N27 cells as an in vitro model for dopamine cell trafficking and metabolism	10
In vitro human skin absorption of ethyl salicylate, pentyl salicylate, and (Z)-3-hexenyl salicylate from topical formulations: Effects on permeation and distribution	10
Exosome proteomics study of the effects of traditional cigarettes and electronic cigarettes on human bronchial epithelial cells	10
Effects of culture media on gene expression in reconstructed human epidermis and THP-1 monocytes for skin sensitization evaluation in co-culture systems	10
Transdermal permeation of inorganic cerium salts in intact human skin	10
Bufadienolides from the Bufo viridis toad venom exert cytotoxic effects on cancer cells by inducing cell apoptosis and cell cycle arrest	9
Strategies for the evaluation of the eye irritation potential of different types of surfactants and silicones used in cosmetic products	9
Biological effects of combustion-derived particles from different biomass sources on human bronchial epithelial cells	9
N-acetyl-L-cysteine attenuated the toxicity of ZIF-8 on EA.hy926 endothelial cells by wnt/β-catenin pathway	9
Editorial Board	9
Investigating the mechanisms of action of thyroid disruptors: A multimodal approach that integrates in vitro and metabolomic analysis	9
Pracaxi oil affects xenobiotic metabolisms, cellular proliferation, and oxidative stress without cytotogenotoxic effects in HepG2/C3A cells	9
Acrylamide-induced damage to postsynaptic plasticity is CYP2E1 dependent in an SH-SY5Y co-culture system	9
Identification of the function and regulatory network of circ_009773 in DNA damage induced by nanoparticles of neodymium oxide	9
In vitro metabolism of lidocaine in subcellular post-mitochondrial fractions and precision cut slices from cattle liver	9
Concentration-dependent effects of chlorpyrifos oxon on peroxisome proliferator-activated receptor signaling in MCF-7 cells	9
Effect of serotonin 7 receptors and transcript variants on RIN-5F pancreatic beta cell line	9
The SNHG10-miR-495-3p-PTEN axis is involved in sevoflurane-mediated protective effects in cardiomyocytes against hypoxia/reoxygenation injury	9
In silico modelling of acute toxicity of 1, 2, 4-triazole antifungal agents towards zebrafish (Danio rerio) embryos: Application of the Small Dataset Modeller tool	9
Everolimus prevents doxorubicin-induced apoptosis in H9c2 cardiomyocytes but not in MCF-7 cancer cells: Cardioprotective roles of autophagy, mitophagy, and AKT	9
Washing with buffered vitamin C after corrosive chemical (sodium hypochlorite) exposure reduces ocular depth of injury	9
Effects of di-(2-ethylhexyl) phthalate and its metabolites on transcriptional activity via human nuclear receptors and gene expression in HepaRG cells	9
Risk assessment of chlorophenols (CPs) exposure in vitro:Inhibition of sulfotransferases (SULTs) activity	9
Cytotoxicity of ZnO nanoparticles in human melanocyte cells in the presence or absence of UV radiation: A preliminary comparative study with TiO2 nanoparticles	8
In vitro toxicological evaluation of a tobacco heating product THP COO and 3R4F research reference cigarette on human lung cancer cells	8
(-)-Epigallocatechin gallate as an inhibitor of hemoglobin-catalyzed lipid oxidation: molecular mechanism of action and nutritional application	8
Polystyrene nanoparticles incorporate into the endoplasmic reticulum and disturb translation during meiotic maturation in mouse oocytes	8
Osthole protects H9c2 cardiomyocytes against trastuzumab-induced damage by enhancing autophagy through the p38MAPK/mTOR signaling pathway	8
Comparative evaluation of HET-CAM and ICE methods for objective assessment of ocular irritation caused by selected pesticide products	8
Mettl3-mediated transcriptome-wide m6A methylation induced by cigarette smoking in human bronchial epithelial cells	8
Study on percutaneous penetration of representative cosmetic ingredients in a baby wipe product in an in vitro diaper rash skin model	8
High-throughput assay for predicting diarrhea risk using a 2D human intestinal stem cell-derived model	8
In vitro eye irritation testing models may play pivotal role in effort to pursue mild baby cleansers	8
Perfluorooctanoic acid inhibits cell proliferation through mitochondrial damage	8
E-cigarette fluids and aerosol residues cause oxidative stress and an inflammatory response in human keratinocytes and 3D skin models	8
Risk assessment of the inhibition of hydroxygenkwanin on human and rat cytochrome P450 by cocktail method	8
The role of efflux transporters in cytotoxicity and intracellular concentration of chlorpyrifos and chlorpyrifos oxon in human cell lines	8
Evaluation of toxicological aspects of three new benzoxazole compounds with sunscreen photophysical properties using in silico and in vitro methods	8
Toxicity of New Psychoactive Substance (NPS): Threo-4-methylmethylphenidate (4-Mmph) – Prediction of toxicity using in silico methods	7
Time dependent impact of copper oxide nanomaterials on the expression of genes associated with oxidative stress, metal binding, inflammation and mucus secretion in single and co-culture intestinal in	7
Long-term in vitro exposure of human granulosa cells to the mixture of endocrine disrupting chemicals found in human follicular fluid disrupts steroidogenesis	7
Chemometric modeling of acute toxicity of diverse aromatic compounds against Rana japonica	7
Pre-validation of a Calu-3 epithelium cytotoxicity assay for predicting acute inhalation toxicity of chemicals	7
The impact of bisphenol AF on skeletal muscle function and differentiation in vitro	7
Telomere loss is accompanied by decreased pool of shelterin proteins TRF2 and RAP1, elevated levels of TERRA and enhanced glycolysis in imatinib-resistant CML cells	7

Mitochondria oxidative stress mediated nicotine-promoted activation of pancreatic stellate cells by regulating mitochondrial dynamics	7
Differential DNA damage response and cell fate in human lung cells after exposure to genotoxic compounds	7
Transcriptomic changes and mitochondrial toxicity in response to acute and repeat dose treatment with brequinar in human liver and kidney in vitro models	7
Busulfan-induced hepatic sinusoidal endothelial cell injury: Modulatory role of pirfenidone for therapeutic purposes	7
Delta-9 tetrahydrocannabinol (THC) effects on the cortisol stress response in bovine granulosa cells	7
6:2 fluorotelomer sulfonate as a safer alternative to PFOS: Comparative cytotoxicity and oxidative stress mechanisms in pancreatic β-cells (INS-1 model)	7
Next generation risk assessment (NGRA): Bridging in vitro points-of-departure to human safety assessment using physiologically-based kinetic (PBK) modelling – A case study of doxorubicin with dose met	7
Lead inhibits the odontogenic differentiation potential of dental pulp stem cells by affecting WNT1/β-catenin signaling and related miRNAs expression	7
Hydroxylation markedly alters how the polychlorinated biphenyl (PCB) congener, PCB52, affects gene expression in human preadipocytes	7
The mechanism of thrombocytopenia caused by cholesterol-conjugated antisense oligonucleotides	7
Dendritic cells activated by cimetidine induce Th1/Th17 polarization in vitro and in vivo	7
Antifungal climbazole alters androgenic pathways in mammalian cells	7
Normalization of organ-on-a-Chip samples for mass spectrometry based proteomics and metabolomics via Dansylation-based assay	7
A novel O2- (2,4-dinitrophenyl) diazeniumdiolate inhibits hepatocellular carcinoma migration, invasion, and EMT through the Wnt/β-catenin pathway	7
Effects of methylation of arginine residue 83 on the enzymatic activity of human arsenic (+3 oxidation state) methyltransferase	7
A battery of in silico models application for pesticides exerting reproductive health effects: Assessment of performance and prioritization of mechanistic studies	7
STF-083010 an inhibitor of IRE1α endonuclease activity affects mitochondrial respiration and generation of mitochondrial membrane potential	7
miRNA-6515-5p regulates particulate matter-induced inflammatory responses by targeting CSF3 in human bronchial epithelial cells	7
Chemotherapeutic effect of baicalein/epirubicin combination against liver cell carcinoma in-vitro: Inducing apoptosis and autophagy	7
m-Cresol,a pesticide intermediate, induces hepatotoxicity and behavioral abnormalities in zebrafish larvae through oxidative stress, apoptosis	7
Cell differentiation in the cardiac embryonic stem cell test (ESTc) is influenced by the oxygen tension in its underlying embryonic stem cell culture	7
In vitro biocompatibility and wound healing properties of latex proteins dressing	7
Blocking Autophagy by the Two-Pore Channels Antagonist Tetrandrine Improves Sorafenib-Induced Death of Hepatocellular Carcinoma Cells	7
Editorial Board	7