Reproductive Toxicology

Article	Citations
Polystyrene microplastics disturb maternal-fetal immune balance and cause reproductive toxicity in pregnant mice	71
Review of the environmental prenatal exposome and its relationship to maternal and fetal health	68
Intrauterine growth restriction: Clinical consequences on health and disease at adulthood	59
Lack of effects on female fertility and prenatal and postnatal offspring development in rats with BNT162b2, a mRNA-based COVID-19 vaccine	51
An analysis of the limitations and uncertainties of in vivo developmental neurotoxicity testing and assessment to identify the potential for alternative approaches	39
Obesity-induced testicular oxidative stress, inflammation and apoptosis: Protective and therapeutic effects of orlistat	39
Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies	39
Reproductive and developmental safety of nirmatrelvir (PF-07321332), an oral SARS-CoV-2 Mpro inhibitor in animal models	37
Exposure to phthalates and female reproductive health: A literature review	35
Maternal exposure to Δ9-tetrahydrocannabinol impairs female offspring glucose homeostasis and endocrine pancreatic development in the rat	34
Neither soy nor isoflavone intake affects male reproductive hormones: An expanded and updated meta-analysis of clinical studies	34
In vitro teratogenicity testing using a 3D, embryo-like gastruloid system	34
Exposure to human relevant mixtures of halogenated persistent organic pollutants (POPs) alters neurodevelopmental processes in human neural stem cells undergoing differentiation	33
Herbicides glyphosate and glufosinate ammonium negatively affect human sperm mitochondria respiration efficiency	30
SARS-COV-2 (Covid-19) and male fertility: Where are we?	29
Rutin prevents cisplatin-induced ovarian damage via antioxidant activity and regulation of PTEN and FOXO3a phosphorylation in mouse model	29
The absence of coronavirus in expressed prostatic secretion in COVID-19 patients in Wuhan city	29
Exposure to Di-2-ethylhexyl phthalate (DEHP) and infertility in women, NHANES 2013-2016	27
Exposure to glyphosate during pregnancy induces neurobehavioral alterations and downregulation of Wnt5a-CaMKII pathway	27
Perfluorononanoic acid impedes mouse oocyte maturation by inducing mitochondrial dysfunction and oxidative stress	27
Sex- and age-dependent effects of maternal organophosphate flame-retardant exposure on neonatal hypothalamic and hepatic gene expression	26
Mechanisms of doxorubicin-mediated reproductive toxicity – A review	25
Perinatal selective serotonin reuptake inhibitor (SSRI) and other antidepressant exposure effects on anxiety and depressive behaviors in offspring: A review of findings in humans and rodent models	25
Morphometric analysis of developing zebrafish embryos allows predicting teratogenicity modes of action in higher vertebrates	25
Predicting risk of low birth weight offspring from maternal features and blood polycyclic aromatic hydrocarbon concentration	23

The potential of mechanistic information organised within the AOP framework to increase regulatory uptake of the developmental neurotoxicity (DNT) in vitro battery of assays	23
Actin binding proteins, actin cytoskeleton and spermatogenesis – Lesson from toxicant models	23
Primary and Secondary Markers of Doxorubicin-Induced Female Infertility and the Alleviative Properties of Quercetin and Vitamin E in a Rat Model	23
Effects of the 2018 Camp Fire on birth outcomes in non-human primates: Case-control study	23
Placental outcomes of phthalate exposure	23
MicroRNA-20a-5p inhibits the autophagy and cisplatin resistance in ovarian cancer via regulating DNMT3B-mediated DNA methylation of RBP1	22
Naringin regulates erectile dysfunction by abolition of apoptosis and inflammation through NOS/cGMP/PKG signalling pathway on exposure to Bisphenol-A in hypertensive rat model	22
Tadalafil alleviates cisplatin-induced reproductive toxicity through the activation of the Nrf2/HO-1 pathway and the inhibition of oxidative stress and apoptosis in male rats	22
The protective effects of pretreatment with resveratrol in cyclophosphamide-induced rat ovarian granulosa cell injury: In vitro study	22
Adverse reproductive function induced by maternal BPA exposure is associated with abnormal autophagy and activating inflamation via mTOR and TLR4/NF-κB signaling pathways in female offspring rats	21
Extravillous trophoblast migration and invasion: Impact of environmental chemicals and pharmaceuticals	21
HAART exacerbates testicular damage and impaired spermatogenesis in anti-Koch-treated rats via dysregulation of lactate transport and glutathione content	21
Evaluation of a panel of in vitro methods for assessing thyroid receptor β and transthyretin transporter disrupting activities	20
Does the food processing contaminant acrylamide cause developmental neurotoxicity? A review and identification of knowledge gaps	20
Prenatal exposure to an environmentally relevant phthalate mixture accelerates biomarkers of reproductive aging in a multiple and transgenerational manner in female mice	20
Perfluorooctanoic acid (PFOA) inhibits the gap junction intercellular communication and induces apoptosis in human ovarian granulosa cells	19
Investigating the effects of fipronil on male fertility: Insight into the mechanism of capacitation	19
Developmental and reproductive safety of AZD1222 (ChAdOx1 nCoV-19) in mice	19
Associations of exposure to phthalates and environmental phenols with gynecological disorders	19
Dose-dependent reproductive toxicity of sodium benzoate in male rats: Inflammation, oxidative stress and apoptosis	19
Prevention and reversal of chlorpromazine induced testicular dysfunction in rats by synergistic testicle-active flavonoids, taurine and coenzyme-10	19
Combining in vitro assays and mathematical modelling to study developmental neurotoxicity induced by chemical mixtures	19
Effects of bisphenol A and bisphenol S on microRNA expression during bovine (Bos taurus) oocyte maturation and early embryo development	19
Exposure to perfluorobutane sulfonate and perfluorooctanesulfonic acid disrupts the production of angiogenesis factors and stress responses in human placental syncytiotrophoblast	18
Machine learning on drug-specific data to predict small molecule teratogenicity	18
Endocrine disruptors and endometriosis	18
A pilot investigation of couple-level phthalates exposure and in vitro fertilization (IVF) outcomes	18
The multi-dimensional embryonic zebrafish platform predicts flame retardant bioactivity	17
Chronic cadmium exposure causes oocyte meiotic arrest by disrupting spindle assembly checkpoint and maturation promoting factor	17
Placental genomic and epigenomic signatures associated with infant birth weight highlight mechanisms involved in collagen and growth factor signaling	17
Folic acid reduces the ethanol-induced morphological and behavioral defects in embryonic and larval zebrafish (Danio rerio) as a model for fetal alcohol spectrum disorder (FASD)	17
Use of the Adverse Outcome Pathway (AOP) framework to evaluate species concordance and human relevance of Dibutyl phthalate (DBP)-induced male reproductive toxicity	17
DNA methylation in polycystic ovary syndrome: Emerging evidence and challenges	16
Maternal obesity increases DNA methylation and decreases RNA methylation in the human placenta	16
Perfluorooctanoic acid promotes proliferation of the human granulosa cell line HGrC1 and alters expression of cell cycle genes and Hippo pathway effector YAP1	16
Effects of bisphenol S and bisphenol F on human spermatozoa: An in vitro study	16
An ontology for developmental processes and toxicities of neural tube closure	16
Perinatal fluoxetine dose-dependently affects prenatal stress-induced neurobehavioural abnormalities, HPA-axis functioning and underlying brain alterations in rat dams and their offspring	16
Hesperidin has a protective effect on paclitaxel-induced testicular toxicity through regulating oxidative stress, apoptosis, inflammation and endoplasmic reticulum stress	16
Gestational and pubertal exposure to low dose of di-(2-ethylhexyl) phthalate impairs sperm quality in adult mice	15
Associations between human internal chemical exposure to Persistent Organic Pollutants (POPs) and In Vitro Fertilization (IVF) outcomes: Systematic review and evidence map of human epidemiological evi	15
Selenium Ameliorates Ibuprofen Induced Testicular Toxicity by Redox Regulation	14
Prenatal alcohol exposure disrupts Sonic hedgehog pathway and primary cilia genes in the mouse neural tube	14
Effects of single and repetitive valproic acid administration on the gene expression of placental transporters in pregnant rats: An analysis by gestational period	14
Evaluation of atrazine neurodevelopment toxicity in vitro-application of hESC-based neural differentiation model	14
Integrating biokinetics and in vitro studies to evaluate developmental neurotoxicity induced by chlorpyrifos in human iPSC-derived neural stem cells undergoing differentiation towards neuronal and gli	14
Prenatal exposure to an environmentally relevant phthalate mixture alters ovarian steroidogenesis and folliculogenesis in the F1 generation of adult female mice	14
Role of aryl hydrocarbon receptor (AHR) in overall retinoid metabolism: Response comparisons to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure between wild-type and AHR knockout mice	14
Iron overload compromises preimplantation mouse embryo development	14
Effects of flame retardants on ovarian function	14

Radiofrequency radiation: A possible threat to male fertility	14
Urinary bisphenol A concentrations and in vitro fertilization outcomes among women from a fertility clinic	14
Prenatal exposure to hexavalent chromium disrupts testicular steroidogenic pathway in peripubertal F1 rats	14
Effects of spike protein and toxin-like peptides found in COVID-19 patients on human 3D neuronal/glial model undergoing differentiation: Possible implications for SARS-CoV-2 impact on brain developmen	14
Focus on germ-layer markers: A human stem cell-based model for in vitro teratogenicity testing	13
Classical toxicity endpoints in female rats are insensitive to the human endocrine disruptors diethylstilbestrol and ketoconazole	13
Perfluorooctane sulfonic acid (PFOS) exposure during pregnancy increases blood pressure and impairs vascular relaxation mechanisms in the adult offspring	13
Breast cancer resistance protein (Bcrp/Abcg2) is selectively modulated by lipopolysaccharide (LPS) in the mouse yolk sac	13
Repression of HDAC5 by acetate restores hypothalamic-pituitary-ovarian function in type 2 diabetes mellitus	13
Excess iodine impairs spermatogenesis by inducing oxidative stress and perturbing the blood testis barrier	12
Vanillin exerts therapeutic effects against hyperglycemia-altered glucose metabolism and purinergic activities in testicular tissues of diabetic rats	12
SRT1720 plays a role in oxidative stress and the senescence of human trophoblast HTR8/SVneo cells induced by D-galactose through the SIRT1/FOXO3a/ROS signalling pathway	12
Distinguishing mode of action of compounds inducing craniofacial malformations in zebrafish embryos to support dose-response modeling in combined exposures	12
Ovarian toxicity of nanoparticles	12
GRP78 plays a key role in sperm function via the PI3K/PDK1/AKT pathway	12
Phthalate monoesters act through peroxisome proliferator-activated receptors in the mouse ovary	12
Parental exposure to benzo(a)pyrene in the peripubertal period impacts reproductive aspects of the F1 generation in rats	12
Prenatal perfluoroalkyl substances and newborn anogenital distance in a Canadian cohort	12
Independent and interactive effects of air pollutants and ambient heat exposure on congenital heart defects	12
Tryptophan and kynurenine stimulate human decidualization via activating Aryl hydrocarbon receptor	12
Gestational vitamin D deficiency impairs fetal lung development through suppressing type II pneumocyte differentiation	11
Hypoxia-induced GPR4 suppresses trophoblast cell migration and proliferation through the MAPK signaling pathway	11
A mixture of persistent organic pollutants detected in human follicular fluid increases progesterone secretion and mitochondrial activity in human granulosa HGrC1 cells	11
“Real life” polycyclic aromatic hydrocarbon (PAH) mixtures modulate hCG, hPL and hPLGF levels and disrupt the physiological ratio of MMP-2 to MMP-9 and VEGF expression in human placenta cell lines	11
Low-dose bisphenol S exposure induces hypospermatogenesis and mitochondrial dysfunction in rats: A possible implication of StAR protein	11
High-dose zearalenone exposure disturbs G2/M transition during mouse oocyte maturation	11
Tributyltin and high‐refined carbohydrate diet lead to metabolic and reproductive abnormalities, exacerbating premature ovary failure features in the female rats	11
Bisphenol analogs AF, S and F: Effects on functional characteristics of porcine granulosa cells	11
Bone toxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and the retinoid system: A causality analysis anchored in osteoblast gene expression and mouse data	11
In vivo and in vitro short-term bisphenol A exposures disrupt testicular energy metabolism and negatively impact spermatogenesis in zebrafish	11
Retinoid signaling in skeletal development: Scoping the system for predictive toxicology	11
Detrimental effects of temephos on male fertility: An in vitro study on a mouse model	11
In utero exposure to arsenite contributes to metabolic and reproductive dysfunction in male offspring of CD-1 mice	11
Novel methods to detect ROS in viable spermatozoa of native semen samples	10
Dose-dependent toxicological effects in rats following a 90-day dietary exposure to PCB-156 include retinoid disruption	10
Neuropsychiatric outcomes in offspring after fetal exposure to maternal influenza infection during pregnancy: A systematic review	10
Scalable expansion of iPSC and their derivatives across multiple lineages	10
Maternal exposure to di(2-ethylhexyl) phthalate (DEHP) causes multigenerational adverse effects on the uterus of F1 and F2 offspring rats.	10
Toxicity from a single injection of human umbilical cord mesenchymal stem cells into rat ovaries	10
Lead and cadmium exposure induces male reproductive dysfunction by modulating the expression profiles of apoptotic and survival signal proteins in tea-garden workers	10
Vitamin D3 protects against lead-induced testicular toxicity by modulating Nrf2 and NF-κB genes expression in rat	10
Maternal use of fluconazole and congenital malformations in the progeny: A meta-analysis of the literature	10
Omega-3 polyunsaturated fatty acids alleviate hydrogen sulfide-induced blood-testis barrier disruption in the testes of adult mice	10
Tangeretin ameliorates erectile and testicular dysfunction in a rat model of hypertension	10
The impact of maternal SARS-CoV-2 infection and COVID-19 vaccination on maternal-fetal outcomes	9
A pilot study: Relationship between Bisphenol A, Bisphenol A glucuronide and sex steroid hormone levels in cord blood in A South African population	9
Melatonin attenuates di-(2-ethylhexyl) phthalate-induced apoptosis of human granulosa cells by inhibiting mitochondrial fission	9
Effects of bisphenols on Blood-Testis Barrier protein expression in vitro: A systematic review and meta-analysis	9
Macrolide and lincosamide antibiotic exposure in the first trimester of pregnancy and risk of congenital anomaly: A European case-control study	9
Comparative effects of TiO2 and ZnO nanoparticles on growth and ultrastructure of ovarian antral follicles	9
Assessment of chemical mixtures using biomarkers of combined biological activity: A screening study in human placentas	9
Using adverse outcome pathways to contextualise (Q)SAR predictions for reproductive toxicity – A case study with aromatase inhibition	9
Fine particulate matter reduces the pluripotency and proliferation of human embryonic stem cells through ROS induced AKT and ERK signaling pathway	9
Metal(loid)s and human semen quality: The LIFE Study	9
Effect of vitamin E deficiency on spermatogenesis in mice and its similarity to aging	9
Codeine alters female reproductive function by targeting ovarian steroidogenesis and folliculogenesis via the induction of oxidative stress, inflammation, and apoptosis	9
Resveratrol ameliorates malathion-induced estrus cycle disorder through attenuating the ovarian tissue oxidative stress, autophagy and apoptosis	9
The unique applicability of the human placenta to the Adverse Outcome Pathway (AOP) concept: the placenta provides fundamental insights into human organ functions at multiple levels of biological orga	9
Vanadium adversely affects sperm motility and capacitation status via protein kinase A activity and tyrosine phosphorylation	9
Piperonyl butoxide, a synergist of pesticides can elicit male-mediated reproductive toxicity	9
The deleterious toxic effects of bifenthrin on male fertility	9
Perinatal exposure to Bisphenol A disturbs the early differentiation of male germ cells	9
Effects of marijuana on human reproduction	9
The reversible reproductive toxicity of 5-fluorouracil in mice	8
Associations of phthalates with prostate cancer among the US population	8
Maternal exposure to perfluoroalkyl chemicals and anogenital distance in the offspring: A Faroese cohort study	8
25th anniversary of the Berlin workshop on developmental toxicology: DevTox database update, challenges in risk assessment of developmental neurotoxicity and alternative methodologies in bone developm	8
Endocrine, metabolic and apical effects of in utero and lactational exposure to non-dioxin-like 2,2′,3,4,4′,5,5′-heptachlorobiphenyl (PCB 180): A postnatal follow-up study in rats	8
Modified Xenopus laevis approach (R-FETAX) as an alternative test for the evaluation of foetal valproate spectrum disorder	8
The impact of isotretinoin on the pituitary-ovarian axis: An interpretative review of the literature	8
Effects of sub-chronic oral exposure to pyrogenic synthetic amorphous silica (NM-203) in male and female Sprague-Dawley rats: focus on reproductive systems	8
Best practices to quantify the impact of reproductive toxicants on development, function, and diseases of the rodent mammary gland	8
Changes in serum heavy metals in polycystic ovary syndrome and their association with endocrine, lipid-metabolism, inflammatory characteristics and pregnancy outcomes	8
Cadmium triggers oxidative stress and mitochondrial injury mediated apoptosis in human extravillous trophoblast HTR-8/SVneo cells	8
Exposure to low doses of malathion during juvenile and peripubertal periods impairs testicular and sperm parameters in rats: Role of oxidative stress and testosterone	8
Effects of Bisphenol A on expression of genes related to amino acid transporters, insulin- like growth factor, aquaporin and amino acid release by porcine trophectoderm cells	8
Dissimilar effects of curcumin on human granulosa cells: Beyond its anti-oxidative role	8
Butylparaben multigenerational reproductive assessment by continuous breeding in Hsd:Sprague Dawley SD rats following dietary exposure	8
Retinoids and developmental neurotoxicity: Utilizing toxicogenomics to enhance adverse outcome pathways and testing strategies	8
Potential protective effect of quercetin on the male reproductive system against exposure of Wistar rats to crude oil vapor: Genetic, biochemical, and histopathological evidence	8

Vitamin C protects early mouse embryos against juglone toxicity	8
Comparing the effects of bisphenol A, C, and F on bovine theca cells in vitro	8
Neurobehavioral, testicular and erectile impairments of chronic ketamine administration: Pathogenesis and ameliorating effect of N-acetyl cysteine	8
Potential environmental toxicant exposure, metabolizing gene variants and risk of PCOS-A systematic review	7
A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) differentially affect glutamate induced excitotoxic responses in chicken cerebellum granule ne	7
Pregnancy outcome following in-utero exposure to ondansetron: A prospective comparative observational study	7
Associations between intrauterine exposure to polychlorinated biphenyls on neonatal ano-genital distance	7
Absence of glyphosate-induced effects on ovarian folliculogenesis and steroidogenesis	7
Inhibition of Sirtuin-1 hyperacetylates p53 and abrogates Sirtuin-1-p53 interaction in Cr(VI)-induced apoptosis in the ovary	7
MiR-let-7d-3p inhibits granulosa cell proliferation by targeting TLR4 in polycystic ovary syndrome	7
Effects of prepubertal exposure to forchlorfenuron through prenatal and postnatal gavage administration in developing Sprague-Dawley rats	7
Pregnancy outcomes in patients treated with leflunomide, the parent compound of the multiple sclerosis drug teriflunomide	7
Associations among maternal perfluoroalkyl substance levels, fetal sex-hormone enzymatic gene polymorphisms, and fetal sex hormone levels in the Hokkaido study	7
Reproductive toxicity of ritonavir in male: Insight into mouse sperm capacitation	7
Review of embryo-fetal developmental toxicity studies performed for pharmaceuticals approved by FDA in 2018 and 2019	7
Paraben exposure alters cell cycle progression and survival of spontaneously immortalized secretory murine oviductal epithelial (MOE) cells	7
Endoderm and mesoderm derivatives in embryonic stem cell differentiation and their use in developmental toxicity testing	7
Prenatal ethanol exposure increases susceptibility to depression- and anxiety-like behavior in adult female offspring and its underlying mechanism	7
Eugenol reduces serum testosterone levels and sperm viability in adult Wistar rats	7
Early postnatal exposure to di(2-ethylhexyl) phthalate causes sex-specific disruption of gonadal development in pigs	7
An efficient neuron-astrocyte differentiation protocol from human embryonic stem cell-derived neural progenitors to assess chemical-induced developmental neurotoxicity	7
Upscaling biological complexity to boost neuronal and oligodendroglia maturation and improve in vitro developmental neurotoxicity (DNT) evaluation	7
Prenatal exposure to the phthalate DEHP impacts reproduction-related gene expression in the pituitary	7
Placental model as an important tool to study maternal-fetal interface	7
EIF3D promotes the progression of preeclampsia by inhibiting of MAPK/ERK1/2 pathway	7