Reproductive Toxicology

Article	Citations
Whole mount preparation and analysis of rabbit mammary gland	74
Editorial Board	62
A low dose of benzo(a)pyrene during prepuberty in male rats generated immediate oxidative stress in the testes and compromised steroidogenic enzymes/proteins	57
Evaluation of reproductive toxicology studies according the OECD Guideline 443 – Claim and reality	50
Perfluorooctane sulfonic acid modulates expression of placental steroidogenesis-associated genes and hormone levels in pregnant rats	45
RETRACTED: Overexpressed miR-106b-5p promotes epithelial-mesenchymal transition in endometriosis by targeting PTEN	40
Epigallocatechin-3-gallate attenuates cyclophosphamide-induced damage in mouse ovarian tissue via suppressing inflammation, apoptosis, and expression of phosphorylated Akt, FOXO3a and rpS6	38
Extended one-generation reproductive toxicity study of food-grade titanium dioxide E171 with emphasis on reproductive and endocrine endpoints	37
Co-administration of atorvastatin with piperine induces reproductive toxicity in male Wistar rats through oxidative stress induction and downregulation of StAR, CYP11a1, 3βHSD and 17βHSD genes	35
Maternal exposure to polystyrene nanoplastics leads to ovotoxicity in female mouse offspring	32
Bisphenol A-induced polycystic ovary syndrome (PCOS) with hormonal and metabolic implications in rats	29
Uterine artery transcriptomic signatures of e-cigarette aerosol exposure in pregnancy	27
Surveys as a valid tool for assessing food safety knowledge amongst pregnant women in high-income countries: a rapid review	26
Risk assessment of dietary exposure to trace elements that are reproductive toxicants: Lead, molybdenum and nickel. The case study of Armenia	26
Abamectin disrupts sperm function through the alteration of PKA activity and tyrosine phosphorylation in boar spermatozoa	26
Small extracellular vesicles derived from Nrf2-stimulated bone marrow mesenchymal stem cells ameliorated the testis damage and fertility disorder in doxorubicin-treated mice	24
Teratogenic and neuro-behavioural toxic effects of bisphenol A (BPA) and B (BPB) on Xenopus laevis development	24
Benzene-induced growth restriction and compensatory rebound in mouse fetuses and placentas	24
Micro- and nanoplastics: Emerging environmental threats to the Developmental Origins of Health and Disease	23
Embryotoxicity analysis of anti-arrhythmia drugs amiodarone, dronedarone, and their metabolites using 3D gastruloid models	23
Metabolic activation of pentachlorophenol: TCBQ as a potent inhibitor of gonadal steroidogenesis via 3β-hydroxysteroid dehydrogenase NAD+ binding-site thiolalkylation	23
Examination of piperonyl butoxide developmental toxicity as a Sonic hedgehog pathway inhibitor targeting limb and palate morphogenesis	22
Causal association between 25-Hydroxyvitamin D and risk of abnormal spermatozoa: A bidirectional Mendelian randomization study	22
Editorial Board	22
Developmental exposure to an environmentally relevant dose of Bisphenol S impairs postnatal growth and disrupts placental transcriptional profile in female rat	21

Critical appraisal of the expert knowledge elicitation (EKE) methodology to identify uncertainties in building cumulative assessment groups for craniofacial alterations	21
Atrazine and diazinon inhibit oocyte maturation and ovulation in zebrafish	21
Cannabinoid exposure does not alter estradiol biosynthesis in human KGN granulosa cells	21
Teratogenic effects of voriconazole (anti-fungal drug) on Swiss albino mice	21
Fatty acid metabolic programming in intrauterine growth restriction: Underlying mechanisms and postnatal consequences	20
Antidepressant aripiprazole induces adverse effects on neural development during cortex organoid generation	20
Cigarette smoke is associated with up-regulation of inducible NOS and COX-2 protein expression and activity in granulosa cells of women undergoing in vitro fertilization	20
Biological variability hampers the use of skeletal staining methods in zebrafish embryo developmental toxicity assays	20
Ethylene oxide impairs sperm motility through dysregulation of Rab proteins	20
Impact of fluoride exposure on reproductive health: Insights into molecular mechanisms and health implications	20
Hesperidin has a protective effect on paclitaxel-induced testicular toxicity through regulating oxidative stress, apoptosis, inflammation and endoplasmic reticulum stress	19
Reprotoxic effect of bisphenol F and bisphenol S on female Drosophila melanogaster exposed during development	19
Quality criteria for in vitro human pluripotent stem cell-derived models of tissue-based cells	19
2,4-dichlorophenoxyacetic acid (2,4-D) exposure during postnatal development alters the effects of western diet on mouse prostate	19
Mechanistic decoding of octyl methoxycinnamate-induced breast toxicity via network toxicology, mendelian randomization, and molecular simulations	18
Bisphenol A exposure advances puberty onset by changing Kiss1 expression firstly in arcuate nucleus at juvenile period in female rats	18
Prostate as a target of endocrine disrupting chemicals: Relevance, pathways, assays	18
Repeat-dose and embryo-fetal developmental toxicity of zinpentraxin alfa	18
Perfluorooctane sulfonate and perfluorooctanoic acid induce plasma membrane dysfunction in boar spermatozoa during in vitro capacitation	18
Teratogenicity and Reactive Oxygen Species after transient embryonic hypoxia: Experimental and clinical evidence with focus on drugs causing failed abortion in humans	18
Melatonin alleviates Di-2-ethylhexyl phthalate induced male reproductive toxicity through inhibition of endoplasmic reticulum stress: Behavioral, biochemical, and morphological evidences	18
Isoliquiritigenin ameliorates paroxetine-induced sexual dysfunction in male albino mice	17
Extended one generation reproductive toxicity study and effect on gut flora of genetically modified rice rich in β-carotene in wistar rats	17
The role of the pentose phosphate pathway in the development of metabolic disorders in the testes during rat intoxication with cypermethrin	17
Contribution of ferritin and zinc to adverse infant outcomes among pregnancies with prenatal alcohol exposure in South Africa	17
Involvement of autophagy and mitophagy modulation in the protective effect of melatonin against BPS-induced ovarian toxicity	17
Fenoxaprop-P-ethyl herbicide induces biochemical, histopathological, and immunohistochemical alterations in the kidneys and testes of rats	17
Adverse Effects of Avobenzone on Boar Sperm Function: Disruption of Protein Kinase A Activity and Tyrosine Phosphorylation	17
Editorial Board	17
Effects of chronic CuNPs treatment followed by termination for two spermatogenic cycles in the testicular functions of mice	17
Exposure to brominated flame retardants during pregnancy and lactation increases the prevalence of breast lesions and cancer-associated pathways in sprague-dawley rats	16
Effects of di-(2-ethylhexyl) terephthalate on hypothalamus-pituitary-gonad axis in adult zebrafish	16
Effect of prenatal exposure to phthalates on birth weight of offspring: A meta-analysis	16
Effect of Lactobacillus plantarum on folliculogenesis in deep frying oil-fed rats	16
A method for quantitative spatial gene expression analysis of mammary gland tissue morphological changes associated with reproductive and developmental toxicity	16
Episodic ozone exposure in Long-Evans rats has limited effects on cauda sperm motility and non-coding RNA populations	16
Editorial: Reproductive and developmental effects of micro- and nano-plastics and plasticizers	16
Toxicity from a single injection of human umbilical cord mesenchymal stem cells into rat ovaries	16
Quaternary ammonium compound exposure causes infertility by altering endocrine signaling and gametogenesis	16
Network toxicology and molecular simulation identify key genes and pathways in PFAS-induced premature ovarian insufficiency	16
Ascorbic acid modulates testicular toxicity of Ampligo® 150 ZC insecticide in male rabbit (Oryctolagus cuniculus)	16
The mechanisms of tripterygium glycosides-induced reproductive toxicity and detoxification strategies	16
Ever cannabis use and biomarkers of male fecundity – A study in the Danish National Birth Cohort	15
Disruption of fetal eye development caused by insulin-induced maternal hypoglycemia in rats	15
Exposure to ethinyl estradiol during lactation reduces maternal mammary gland complexity and restricts pup growth in mice	15
Lipopolysaccharide-induced inflammation modulates testicular kisspeptin system in mice	15
Psychosocial stress and associations with inflammation in mid-gestation maternal, fetal, and placental tissue	15
Molecular mechanisms associated with embryotoxic effects of heavy metals in the Sea Urchin	15
Evaluation of cytoprotective effects of cannabidiol on neuroinflammation and neurogenesis process in rat offsprings	15
Impact of Bisphenol A exposure on maternal gut microbial homeostasis, placental function, and fetal development during pregnancy	14

The role of adenosine triphosphate in the treatment of linezolid-induced ovarian damage and reproductive dysfunction in rats: An investigation into the pathogenesis	14
Intestinal microbiome in response to air pollutant exposure in pregestational and gestational murine females and their male and female offspring	14
Silibinin attenuates 3-nitropropionic acid-induced ovarian toxicity by alleviating oxidative stress and granulosa cell apoptosis	14
Trichlorfon blocks androgen synthesis and metabolism in rat immature Leydig cells	13
Embryotoxicity of statins and other prescribed drugs with reported off-target effects on cholesterol biosynthesis	13
Folate in maternal rheumatoid arthritis-filial autism spectrum disorder continuum	13
Zebrafish embryos as a teratogenicity screening tool to reduce potential birth defects	13
Clonidine compromises human sperm functions	13
Maternal chronic caffeine intake impairs fertility, placental vascularization and fetal development in mice	13
Epididymal toxicity of deoxynivalenol: Age-specific effects in prepubertal and adult mice	13
Neurotensin receptor-1 antagonist SR48692 modulation of high-fat diet induced reproductive impairment in male mice	12
Association between polycyclic aromatic hydrocarbons and infertility in U.S. women: National Health and Nutrition Examination Survey 2013–2016	12
Maternal PM2.5 exposure causes fetal growth restriction and alters placental morphology: Role of uterine inflammation	12
Investigating the protective role of Astragalus polysaccharides against fluoride-induced testicular injury via network pharmacology, molecular docking, and in vivo experiments	12
β-caryophyllene mitigates metabolic dysfunction in the testes of gerbils perinatally exposed to BPA	12
Maternal 129S1/SvImJ background attenuates the placental phenotypes induced by chronic paternal alcohol exposure	12
Safety of lactational exposure to venlafaxine on the rat mammary gland development and carcinogenesis in F1 female offspring	12
Association between dietary intake estimated levels of PCDD/Fs and human sperm quality	12
Reduced food consumption triggers abortion in antibiotic-treated pregnant rabbits: Insights from a pair-feeding study	12
Air pollution-linked epigenetic modifications in placental DNA: Prognostic potential for identifying future foetal anomalies	12
Glycine intervention can alleviate imidacloprid-induced spermatogenic damage in rats	12
Impacts of heavy metal exposure on the prostate of murine models: Mechanisms of toxicity	12
Comprehensive digital documentation of teratology studies	12
Immunogenicity-related placental infarcts and abortions in nonhuman primate developmental and reproductive toxicity studies: Proposed mechanism and impact on study interpretation	12
Subacute high-refined carbohydrate diet leads to abnormal reproductive control of the hypothalamic-pituitary axis in female rats	12
Xeno-estrogenic activity of real-life mixtures of perfluoroalkylated substances in human placenta homogenates	11
The effects of exposure to microplastics on female reproductive health and pregnancy outcomes: A systematic review and meta-analysis	11
Fish oil supplementation protects against protein undernutrition-induced testicular and ovarian biochemical alterations in rats	11
Propylparaben negatively impacts IN VITRO preimplantation mouse embryo development	11
Effects of a TAML catalyst on mice exposed during pregnancy and lactation	11
Effects of perinatal exposures to a TAML catalyst on the mammary gland and hormone-sensitive outcomes in male mice	11
Protective role of hesperidin in finasteride-induced testicular toxicity in adult male Wistar rats: Insights into oxidative stress, apoptosis, and ultrastructure of seminiferous tubules	11
Placental BCRP transporter reduces cadmium accumulation and toxicity in immortalized human trophoblasts	11
Cadmium exposure causes trophoblast abnormal syncytization and endocrine dysfunction in preeclampsia	11
Protocatechualdehyde improves cyclophosphamide-induced premature ovarian insufficiency by inhibiting granulosa cell apoptosis and senescence through the SIRT1/p53 axis	11
The consumption of monosodium glutamate during the periconceptional period can impair preimplantation embryo development	11
BDE-47 has cytotoxicity on human sperm by inducing apoptosis, mitochondrial dysfunction, and membrane damage	10
Prenatal caffeine consumption and neurobehavioral disorders - A systematic review	10
DNA methylation in polycystic ovary syndrome: Emerging evidence and challenges	10
Impact of endocrine disruptors from mother's diet on immuno-hormonal orchestration of brain development and introduction of the virtual human twin tool	10
Exposure to di-isononyl phthalate during early pregnancy disrupts decidual angiogenesis and placental development in mice	10
Effects of DDT and DDE on placental cholinergic receptors	10
Associations between urinary and follicular fluid concentrations of phthalate metabolites and reproductive outcomes in Brazilian women undergoing fertility treatment	10
Potential protective effect of beta-caryophyllene against cadmium chloride-induced damage to the male reproductive system in mouse	10
Subcutaneous zilucoplan: Evaluation of reproductive toxicology	10
Fetal imaging with microCT (µCT) in the age of AI	10
Editorial Board	10
Considerations for and against dosing rodent pups before 7 days of age in juvenile toxicology studies	10
Shatavarin-IV rescues the Di (2-ethylhexyl) phthalate (DEHP) induced oxidative stress in rat granulosa cells in vitro	10
Exposure to low-dose polystyrene nanoplastics impairs the estrous cycle by decreasing ovarian levels of steroidogenic acute regulatory protein and serum progesterone levels in rats	10
AOP key event relationship report: Linking decreased androgen receptor activation with decreased granulosa cell proliferation of gonadotropin-independent follicles	10
Maternal preconception and pregnancy tobacco and cannabis use in relation to placental developmental markers: A population-based study	10
Protective effect of ginsenoside Rg3 on DBP-induced spermatogenesis injury via the Src/PI3K signaling pathway	10
Bisphenol A analogues and metabolic syndrome in women with polycystic ovary syndrome	10
Low levels of nicotine and cotinine but not benzo[a]pyrene induce human trophoblast cell proliferation	10
Potential dual protective effects of melatonin on spermatogonia against hexavalent chromium	10
Cannabis sativa extract and fertility: Preclinical evaluation in male and female Wistar rats	9
Advancing the use of new approach methodologies for assessing teratogenicity: Building a tiered approach	9
Chronic iron overload disrupts the reproductive tract and leads to infertility: From a clinical case report to the experimental study of reproduction in female mice	9
Editorial Board	9
Editorial Board	9
New approach methodologies to confirm developmental toxicity of pharmaceuticals based on weight of evidence	9
Prolonged exposure to rosuvastatin from pre-puberty to adulthood impairs sperm quality in mice and leads to paternally mediated developmental toxicity	9
Editorial Board	9
Associations between per- and polyfluoroalkyl substances and reproductive outcomes among women undergoing in vitro fertilization/intracytoplasmic sperm injection treatment	9
The influence of lead exposure on male semen parameters: A systematic review and meta-analysis	9
A dynamic in vitro developing testis model reflects structures and functions of testicular development in vivo	9
Editorial Board	9
In vivo pharmacokinetic analyses of placental transfer of three drugs of different physicochemical properties in pregnant rats	9
Effect of 1-nitropyrene exposure on the biological behavior of trophoblast cells	9
Diuron-induced fetal Leydig cell dysfunction in in vitro organ cultured fetal testes	9
Hypothesis-driven approach to developmental toxicity assessment: Using mechanistic information to inform testing	9
Mechanisms underlying impaired spermatogenic function in orchitis induced by busulfan	9
Erroneous statement	9
Independent and interaction effects of prenatal exposure to high AQI and extreme Humidex on the risk of preterm birth: A large sample population study in northern China	9
Prenatal high-sucrose diet affects pulmonary artery contractile functions via MT receptors	9
Alkali and alkaline earth elements in maternal serum and occurrence of orofacial clefts in offspring	8
Sucralose triggers insulin resistance leading to follicular dysplasia in mice	8
Development of a microfluidic system structured on a modified polydimethylsiloxane device for the selection of bovine epididymal spermatozoa	8
Micro- and nanoplastics and brain sexual differentiation: An emerging neurodevelopmental threat within the DOHaD framework	8

An analysis of birth defects and developmental disabilities for children of participants of the Air Force Health Study	8
Associations of area-level and individual-level sociodemographic factors with adolescent phenotypes linked to subsequent cancer risk	8
Association between menopausal age and smoking status defined using urinary cotinine or tobacco-specific nitrosamine metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol: The Korea National Health	8
Prenatal and postnatal exposure to polychlorinated biphenyls alter follicle numbers, gene expression, and a proliferation marker in the rat ovary	8
The mediating role of abnormal ZEB1 methylation in the association between nickel exposure and non-syndromic orofacial cleft	8
Neuropsychiatric outcomes in offspring after fetal exposure to maternal influenza infection during pregnancy: A systematic review	8
Role of Rab proteins in PFOA-induced changes in boar sperm motility and capacitation	8
Hormonal mechanism and pathogenetic therapy of citalopram-induced infertility in female rats	8
Exposure to Valproic acid (VPA) resulted in alterations in the expression of angiogenic genes (NRP-1, VEGFA, VEGFR-2 and sFlt1) and histological modifications in the placenta of mice (Mus musculus)	8
The fate of bisphenol A, bisphenol S, and their respective glucuronide metabolites in ovarian cells	8
Screening for chemicals with thyroid hormone-disrupting effects using zebrafish embryo	8
Effectiveness of Withania frutescens root extract on testicular damage induced by lead acetate in adult albino rats	8
Vitamin D supplementation stimulates germ cell proliferation in a restraint-stressed mouse	8
Human umbilical cord mesenchymal stem cell-derived exosomes repair raloxifene-induced damage in endometrial stromal cells via autophagy activation	8
Biological sex differences in hepatic response to in utero dimethylbenz(a)anthracene exposure	8
Ulipristal (UPA) effects on rat ovaries: Unraveling follicle dynamics, ovulation inhibition, and safety implications for prolonged use	8
Effects of oridonin on sperm function and the PI3K/PDK1/AKT signaling pathway: Implications for reproductive toxicity	8
Synthetic human gonadal tissues for toxicology	8
Phthalates and polycystic ovary syndrome – Systematic literature review	8
Ampligo® 150 ZC affect the expression of sex hormone receptors and cell proliferation marker in female rabbit ovary: Protective effects of thyme essential oil and vitamin C	8
Vulnerable periods for the mouse mammary gland: Comparison of the effects of ethinyl estradiol exposures during two early stages of development	8
Effects of non-nutritive sweeteners on the sweet taste receptor expression and reproductive function in female guinea pigs	8
Glycine improves PFOS induced inhibition of in vitro development of porcine oocytes by reducing ferroptosis	8
Editorial Board	8
Bisphenol M inhibits mouse oocyte maturation in vitro by disrupting cytoskeleton architecture and cell cycle processes	7
Editorial Board	7
Lack of direct bone effect of tofacitinib, a JAK inhibitor, in juvenile rats and evaluation of the association between offspring growth and femur length	7
Blastocyst exposure to plastic during mice in vitro fertilization impacts placental development	7
1-(N-methyl-N-nitrosamino)-1-(3-pyridinyl)-4-butanal exposure induces testicular toxicity in male mice	7
Reproductive toxicity mechanisms of PNMC: Evidence from mitochondrial dysfunction and hormone synthesis disruption in the KGN cells	7
Associations between the proliferation of palatal mesenchymal cells, Tgfβ2 promoter methylation, Meg3 expression, and Smad signaling in atRA-induced cleft palate	7
Identification of endocrine disrupting chemicals targeting NTD-related hub genes during pregnancy via in silico analysis	7
The associations between prenatal plastic phthalate exposure and lipid acylcarnitine levels in humans and mice	7
Subacute exposure to a mixture of tributyltin plus mercury impairs reproductive axis function, exacerbating premature ovarian insufficiency features and reducing fertility in female rats	7
Metabolic reprogramming and organelle quality control: The “silent” drivers of Sertoli cell dysfunction under environmental stressors	7
Pubertal sexual development and endpoints for disrupted spermatogenesis in the model Xenopus tropicalis	7
Prenatal exposure to corn oil, CMC-Na or DMSO affects physical development and multi-organ functions in fetal mice	7
In utero exposure to estrogenic bisphenol analogues increases mammary tissue stiffness	7
Nicotinamide mononucleotide enhances the developmental potential of mouse early embryos exposed to perfluorooctanoic acid	7
Corrigendum to “Relationship of parental phthalate exposure with fetal growth and placental development at birth” [Reprod. Toxicol. 137 (2025) 109025]	7
Effects of bisphenol A and bisphenol S on human fallopian tube contractions: An in vitro and in silico study	7
Toxicity of cerium oxide nanoparticles on neonatal testicular development in mouse organ culture	7
Smoking during pregnancy is associated with the placental proteome	7
The effect of cigarette exposure on placental epigenetics: A systematic review	7
Protective effect of Chlorella vulgaris on testicular damage, sperm parameters, androgen production, apoptosis and oxidative stress index in male rats following doxorubicin administration	7
Ultra-diluted/dynamized doxorubicin reduces the toxicity caused by doxorubicin during the in vitro culture of pig preantral follicles enclosed in ovarian tissue	7
Use of leflunomide among girls and women of childbearing age and occurrence of leflunomide-exposed pregnancies in Germany	7
Folic acid alleviates fetal growth restriction induced by gestational Di (2-ethylhexyl) phthalate exposure in mice through activating the STAT3/HIF-1α/VEGFA signaling pathway	7
Endocrine-disrupting effects of titanium dioxide nanoparticles on the female reproductive system: Evidence from an ovariectomized rat model	7
Subacute tributyltin exposure alters the development and morphology of mammary glands in association with CYP19A1 expression in female rats	7
Aqueous cigarette smoke extract reduces mitochondrial potential and increases nuclear degeneration in bovine oocytes matured in vitro	7
Vincristine induces sperm malformation and motility dysfunction in mice by downregulating Tssk4 and Ccdc159	7
Endocrine disruptors and endometriosis	7
Impact of the environmental endocrine disruptor flutamide on cryptorchidism: Molecular mechanisms involving connexin-43 and p38-MAPK signaling	7
Evaluation of the maternal and developmental toxicity of 6-methylmercaptopurine riboside in rats	7
Upscaling biological complexity to boost neuronal and oligodendroglia maturation and improve in vitro developmental neurotoxicity (DNT) evaluation	7