Reproductive Toxicology

Article	Citations
RETRACTED: Overexpressed miR-106b-5p promotes epithelial-mesenchymal transition in endometriosis by targeting PTEN	177
Risk assessment of dietary exposure to trace elements that are reproductive toxicants: Lead, molybdenum and nickel. The case study of Armenia	102
Editorial Board	56
A low dose of benzo(a)pyrene during prepuberty in male rats generated immediate oxidative stress in the testes and compromised steroidogenic enzymes/proteins	54
Surveys as a valid tool for assessing food safety knowledge amongst pregnant women in high-income countries: a rapid review	51
Small extracellular vesicles derived from Nrf2-stimulated bone marrow mesenchymal stem cells ameliorated the testis damage and fertility disorder in doxorubicin-treated mice	48
Abamectin disrupts sperm function through the alteration of PKA activity and tyrosine phosphorylation in boar spermatozoa	44
Maternal exposure to polystyrene nanoplastics leads to ovotoxicity in female mouse offspring	39
Extended one-generation reproductive toxicity study of food-grade titanium dioxide E171 with emphasis on reproductive and endocrine endpoints	33
Embryotoxicity analysis of anti-arrhythmia drugs amiodarone, dronedarone, and their metabolites using 3D gastruloid models	31
Evaluation of reproductive toxicology studies according the OECD Guideline 443 – Claim and reality	29
Co-administration of atorvastatin with piperine induces reproductive toxicity in male Wistar rats through oxidative stress induction and downregulation of StAR, CYP11a1, 3βHSD and 17βHSD genes	29
Epigallocatechin-3-gallate attenuates cyclophosphamide-induced damage in mouse ovarian tissue via suppressing inflammation, apoptosis, and expression of phosphorylated Akt, FOXO3a and rpS6	27
Bisphenol A-induced polycystic ovary syndrome (PCOS) with hormonal and metabolic implications in rats	27
Teratogenic and neuro-behavioural toxic effects of bisphenol A (BPA) and B (BPB) on Xenopus laevis development	27
Perfluorooctane sulfonic acid modulates expression of placental steroidogenesis-associated genes and hormone levels in pregnant rats	26
Whole mount preparation and analysis of rabbit mammary gland	25
Editorial Board	23
Causal association between 25-Hydroxyvitamin D and risk of abnormal spermatozoa: A bidirectional Mendelian randomization study	22
Melatonin alleviates Di-2-ethylhexyl phthalate induced male reproductive toxicity through inhibition of endoplasmic reticulum stress: Behavioral, biochemical, and morphological evidences	21
Prostate as a target of endocrine disrupting chemicals: Relevance, pathways, assays	21
Teratogenic effects of voriconazole (anti-fungal drug) on Swiss albino mice	21
Biological variability hampers the use of skeletal staining methods in zebrafish embryo developmental toxicity assays	21
Mechanistic decoding of octyl methoxycinnamate-induced breast toxicity via network toxicology, mendelian randomization, and molecular simulations	21
Cannabinoid exposure does not alter estradiol biosynthesis in human KGN granulosa cells	20

Developmental exposure to an environmentally relevant dose of Bisphenol S impairs postnatal growth and disrupts placental transcriptional profile in female rat	20
Bisphenol A exposure advances puberty onset by changing Kiss1 expression firstly in arcuate nucleus at juvenile period in female rats	19
2,4-dichlorophenoxyacetic acid (2,4-D) exposure during postnatal development alters the effects of western diet on mouse prostate	19
Comment on “Effects of the 2018 camp fire on birth outcomes in non-human primates: Case-control study”	19
Long-term transplantation human menstrual blood mesenchymal stem cell loaded collagen scaffolds repair endometrium histological injury	19
Cigarette smoke is associated with up-regulation of inducible NOS and COX-2 protein expression and activity in granulosa cells of women undergoing in vitro fertilization	19
Critical appraisal of the expert knowledge elicitation (EKE) methodology to identify uncertainties in building cumulative assessment groups for craniofacial alterations	19
Teratogenicity and Reactive Oxygen Species after transient embryonic hypoxia: Experimental and clinical evidence with focus on drugs causing failed abortion in humans	18
Repeat-dose and embryo-fetal developmental toxicity of zinpentraxin alfa	18
Examination of piperonyl butoxide developmental toxicity as a Sonic hedgehog pathway inhibitor targeting limb and palate morphogenesis	18
Impact of fluoride exposure on reproductive health: Insights into molecular mechanisms and health implications	18
Reprotoxic effect of bisphenol F and bisphenol S on female Drosophila melanogaster exposed during development	18
Antidepressant aripiprazole induces adverse effects on neural development during cortex organoid generation	17
Prenatal exposure to the phthalate DEHP impacts reproduction-related gene expression in the pituitary	17
Editorial Board	17
Quality criteria for in vitro human pluripotent stem cell-derived models of tissue-based cells	17
Evaluation of cytoprotective effects of cannabidiol on neuroinflammation and neurogenesis process in rat offsprings	17
Perfluorooctane sulfonate and perfluorooctanoic acid induce plasma membrane dysfunction in boar spermatozoa during in vitro capacitation	17
Hesperidin has a protective effect on paclitaxel-induced testicular toxicity through regulating oxidative stress, apoptosis, inflammation and endoplasmic reticulum stress	17
Contribution of ferritin and zinc to adverse infant outcomes among pregnancies with prenatal alcohol exposure in South Africa	17
Effect of Lactobacillus plantarum on folliculogenesis in deep frying oil-fed rats	16
Extended one generation reproductive toxicity study and effect on gut flora of genetically modified rice rich in β-carotene in wistar rats	16
Effects of di-(2-ethylhexyl) terephthalate on hypothalamus-pituitary-gonad axis in adult zebrafish	16
Ascorbic acid modulates testicular toxicity of Ampligo® 150 ZC insecticide in male rabbit (Oryctolagus cuniculus)	16
Fenoxaprop-P-ethyl herbicide induces biochemical, histopathological, and immunohistochemical alterations in the kidneys and testes of rats	16
Toxicity from a single injection of human umbilical cord mesenchymal stem cells into rat ovaries	16
Adverse Effects of Avobenzone on Boar Sperm Function: Disruption of Protein Kinase A Activity and Tyrosine Phosphorylation	16
Maternal trichloroethylene exposure and metabolic gene polymorphisms may interact during fetal cardiovascular malformation	16
Episodic ozone exposure in Long-Evans rats has limited effects on cauda sperm motility and non-coding RNA populations	15
Effects of chronic CuNPs treatment followed by termination for two spermatogenic cycles in the testicular functions of mice	15
The role of the pentose phosphate pathway in the development of metabolic disorders in the testes during rat intoxication with cypermethrin	15
Quaternary ammonium compound exposure causes infertility by altering endocrine signaling and gametogenesis	15
The mechanisms of tripterygium glycosides-induced reproductive toxicity and detoxification strategies	15
Involvement of autophagy and mitophagy modulation in the protective effect of melatonin against BPS-induced ovarian toxicity	15
Effect of prenatal exposure to phthalates on birth weight of offspring: A meta-analysis	15
Exposure to brominated flame retardants during pregnancy and lactation increases the prevalence of breast lesions and cancer-associated pathways in sprague-dawley rats	15
Isoliquiritigenin ameliorates paroxetine-induced sexual dysfunction in male albino mice	14
Zebrafish embryos as a teratogenicity screening tool to reduce potential birth defects	14
Single cell RNA sequencing techniques and applications in research of ovary development and related diseases	14
Lipopolysaccharide-induced inflammation modulates testicular kisspeptin system in mice	14
Exposure to ethinyl estradiol during lactation reduces maternal mammary gland complexity and restricts pup growth in mice	14
Embryotoxicity of statins and other prescribed drugs with reported off-target effects on cholesterol biosynthesis	14
Network toxicology and molecular simulation identify key genes and pathways in PFAS-induced premature ovarian insufficiency	14
Molecular mechanisms associated with embryotoxic effects of heavy metals in the Sea Urchin	14
Folate in maternal rheumatoid arthritis-filial autism spectrum disorder continuum	14
Current knowledge, challenges, new perspectives of the study, and treatments of Autism Spectrum Disorder	14
Comprehensive digital documentation of teratology studies	13
Maternal chronic caffeine intake impairs fertility, placental vascularization and fetal development in mice	13
Silibinin attenuates 3-nitropropionic acid-induced ovarian toxicity by alleviating oxidative stress and granulosa cell apoptosis	13
Disruption of fetal eye development caused by insulin-induced maternal hypoglycemia in rats	13

Effects of a TAML catalyst on mice exposed during pregnancy and lactation	13
Association between dietary intake estimated levels of PCDD/Fs and human sperm quality	13
Impacts of heavy metal exposure on the prostate of murine models: Mechanisms of toxicity	13
Psychosocial stress and associations with inflammation in mid-gestation maternal, fetal, and placental tissue	13
Impact of Bisphenol A exposure on maternal gut microbial homeostasis, placental function, and fetal development during pregnancy	13
Glycine intervention can alleviate imidacloprid-induced spermatogenic damage in rats	13
Ever cannabis use and biomarkers of male fecundity – A study in the Danish National Birth Cohort	13
Trichlorfon blocks androgen synthesis and metabolism in rat immature Leydig cells	13
Investigating the protective role of Astragalus polysaccharides against fluoride-induced testicular injury via network pharmacology, molecular docking, and in vivo experiments	13
Association between polycyclic aromatic hydrocarbons and infertility in U.S. women: National Health and Nutrition Examination Survey 2013–2016	12
Maternal 129S1/SvImJ background attenuates the placental phenotypes induced by chronic paternal alcohol exposure	12
Associations between urinary and follicular fluid concentrations of phthalate metabolites and reproductive outcomes in Brazilian women undergoing fertility treatment	12
Propylparaben negatively impacts IN VITRO preimplantation mouse embryo development	12
The effects of exposure to microplastics on female reproductive health and pregnancy outcomes: A systematic review and meta-analysis	12
Subacute high-refined carbohydrate diet leads to abnormal reproductive control of the hypothalamic-pituitary axis in female rats	12
Air pollution-linked epigenetic modifications in placental DNA: Prognostic potential for identifying future foetal anomalies	12
Subcutaneous zilucoplan: Evaluation of reproductive toxicology	12
Fish oil supplementation protects against protein undernutrition-induced testicular and ovarian biochemical alterations in rats	12
Safety of lactational exposure to venlafaxine on the rat mammary gland development and carcinogenesis in F1 female offspring	12
Cadmium exposure causes trophoblast abnormal syncytization and endocrine dysfunction in preeclampsia	12
Immunogenicity-related placental infarcts and abortions in nonhuman primate developmental and reproductive toxicity studies: Proposed mechanism and impact on study interpretation	12
Protective role of hesperidin in finasteride-induced testicular toxicity in adult male Wistar rats: Insights into oxidative stress, apoptosis, and ultrastructure of seminiferous tubules	12
Potential protective effect of beta-caryophyllene against cadmium chloride-induced damage to the male reproductive system in mouse	12
Neurotensin receptor-1 antagonist SR48692 modulation of high-fat diet induced reproductive impairment in male mice	12
Zearalenone interferes with the sperm-triggered inflammation in the bovine uterus in vitro: Negative impact on sperm motility and survival	11
Protective effect of ginsenoside Rg3 on DBP-induced spermatogenesis injury via the Src/PI3K signaling pathway	11
The consumption of monosodium glutamate during the periconceptional period can impair preimplantation embryo development	11
AOP key event relationship report: Linking decreased androgen receptor activation with decreased granulosa cell proliferation of gonadotropin-independent follicles	11
Prenatal caffeine consumption and neurobehavioral disorders - A systematic review	11
Placental BCRP transporter reduces cadmium accumulation and toxicity in immortalized human trophoblasts	11
Xeno-estrogenic activity of real-life mixtures of perfluoroalkylated substances in human placenta homogenates	11
Exposure to low-dose polystyrene nanoplastics impairs the estrous cycle by decreasing ovarian levels of steroidogenic acute regulatory protein and serum progesterone levels in rats	11
Maternal preconception and pregnancy tobacco and cannabis use in relation to placental developmental markers: A population-based study	11
Impact of endocrine disruptors from mother's diet on immuno-hormonal orchestration of brain development and introduction of the virtual human twin tool	11
Protocatechualdehyde improves cyclophosphamide-induced premature ovarian insufficiency by inhibiting granulosa cell apoptosis and senescence through the SIRT1/p53 axis	10
DNA methylation in polycystic ovary syndrome: Emerging evidence and challenges	10
Low levels of nicotine and cotinine but not benzo[a]pyrene induce human trophoblast cell proliferation	10
Effects of perinatal exposures to a TAML catalyst on the mammary gland and hormone-sensitive outcomes in male mice	10
Considerations for and against dosing rodent pups before 7 days of age in juvenile toxicology studies	10
Editorial Board	10
Respiratory exposure to carbon black nanoparticles may induce testicular structure damage and lead to decreased sperm quality in mice	10
Exposure to di-isononyl phthalate during early pregnancy disrupts decidual angiogenesis and placental development in mice	10
Mechanisms underlying impaired spermatogenic function in orchitis induced by busulfan	9
Bisphenol A analogues and metabolic syndrome in women with polycystic ovary syndrome	9
Chronic iron overload disrupts the reproductive tract and leads to infertility: From a clinical case report to the experimental study of reproduction in female mice	9
Diuron-induced fetal Leydig cell dysfunction in in vitro organ cultured fetal testes	9
Potential dual protective effects of melatonin on spermatogonia against hexavalent chromium	9
Effects of DDT and DDE on placental cholinergic receptors	9
Advancing the use of new approach methodologies for assessing teratogenicity: Building a tiered approach	9
A dynamic in vitro developing testis model reflects structures and functions of testicular development in vivo	9
Editorial Board	9
The influence of lead exposure on male semen parameters: A systematic review and meta-analysis	9
Editorial Board	9
Shatavarin-IV rescues the Di (2-ethylhexyl) phthalate (DEHP) induced oxidative stress in rat granulosa cells in vitro	9
Hypothesis-driven approach to developmental toxicity assessment: using mechanistic information to inform testing	9
Transgenerational effects of bisphenol A on zebrafish reproductive tissues and sperm motility	9
Independent and interaction effects of prenatal exposure to high AQI and extreme Humidex on the risk of preterm birth: A large sample population study in northern China	8
Sucralose triggers insulin resistance leading to follicular dysplasia in mice	8
The mediating role of abnormal ZEB1 methylation in the association between nickel exposure and non-syndromic orofacial cleft	8
Editorial Board	8
Neuropsychiatric outcomes in offspring after fetal exposure to maternal influenza infection during pregnancy: A systematic review	8
Cannabis sativa extract and fertility: Preclinical evaluation in male and female Wistar rats	8
Effects of non-nutritive sweeteners on the sweet taste receptor expression and reproductive function in female guinea pigs	8
Prenatal high-sucrose diet affects pulmonary artery contractile functions via MT receptors	8
Erroneous statement	8
Editorial Board	8
Editorial Board	8
Prolonged exposure to rosuvastatin from pre-puberty to adulthood impairs sperm quality in mice and leads to paternally mediated developmental toxicity	8
Effect of 1-nitropyrene exposure on the biological behavior of trophoblast cells	8
Prenatal and postnatal exposure to polychlorinated biphenyls alter follicle numbers, gene expression, and a proliferation marker in the rat ovary	8
The fate of bisphenol A, bisphenol S, and their respective glucuronide metabolites in ovarian cells	8
New approach methodologies to confirm developmental toxicity of pharmaceuticals based on weight of evidence	8
In vivo pharmacokinetic analyses of placental transfer of three drugs of different physicochemical properties in pregnant rats	8
Biological sex differences in hepatic response to in utero dimethylbenz(a)anthracene exposure	8
Vitamin D supplementation stimulates germ cell proliferation in a restraint-stressed mouse	8
Human umbilical cord mesenchymal stem cell-derived exosomes repair raloxifene-induced damage in endometrial stromal cells via autophagy activation	8
Ampligo® 150 ZC affect the expression of sex hormone receptors and cell proliferation marker in female rabbit ovary: Protective effects of thyme essential oil and vitamin C	7
In utero exposure to estrogenic bisphenol analogues increases mammary tissue stiffness	7
Associations of area-level and individual-level sociodemographic factors with adolescent phenotypes linked to subsequent cancer risk	7
Screening for chemicals with thyroid hormone-disrupting effects using zebrafish embryo	7

Metal(loid)s and human semen quality: The LIFE Study	7
Exposure to Valproic acid (VPA) resulted in alterations in the expression of angiogenic genes (NRP-1, VEGFA, VEGFR-2 and sFlt1) and histological modifications in the placenta of mice (Mus musculus)	7
Editorial Board	7
Association between menopausal age and smoking status defined using urinary cotinine or tobacco-specific nitrosamine metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol: The Korea National Health	7
Subacute tributyltin exposure alters the development and morphology of mammary glands in association with CYP19A1 expression in female rats	7
Development of a microfluidic system structured on a modified polydimethylsiloxane device for the selection of bovine epididymal spermatozoa	7
Synthetic human gonadal tissues for toxicology	7
Effects of oridonin on sperm function and the PI3K/PDK1/AKT signaling pathway: Implications for reproductive toxicity	7
Hormonal mechanism and pathogenetic therapy of citalopram-induced infertility in female rats	7
Alkali and alkaline earth elements in maternal serum and occurrence of orofacial clefts in offspring	7
Vulnerable periods for the mouse mammary gland: Comparison of the effects of ethinyl estradiol exposures during two early stages of development	7
An analysis of birth defects and developmental disabilities for children of participants of the Air Force Health Study	7
Phthalates and polycystic ovary syndrome – Systematic literature review	7
Ultra-diluted/dynamized doxorubicin reduces the toxicity caused by doxorubicin during the in vitro culture of pig preantral follicles enclosed in ovarian tissue	7
Nicotinamide mononucleotide enhances the developmental potential of mouse early embryos exposed to perfluorooctanoic acid	7
Effectiveness of Withania frutescens root extract on testicular damage induced by lead acetate in adult albino rats	7
Ulipristal (UPA) effects on rat ovaries: Unraveling follicle dynamics, ovulation inhibition, and safety implications for prolonged use	7
Role of Rab proteins in PFOA-induced changes in boar sperm motility and capacitation	7
Subacute exposure to a mixture of tributyltin plus mercury impairs reproductive axis function, exacerbating premature ovarian insufficiency features and reducing fertility in female rats	6
Effect of ofatumumab on pregnancy, parturition, and lactation in cynomolgus monkeys	6
Associations between the proliferation of palatal mesenchymal cells, Tgfβ2 promoter methylation, Meg3 expression, and Smad signaling in atRA-induced cleft palate	6
Editorial Board	6
The impact of maternal SARS-CoV-2 infection and COVID-19 vaccination on maternal-fetal outcomes	6
Bisphenol M inhibits mouse oocyte maturation in vitro by disrupting cytoskeleton architecture and cell cycle processes	6
Association of environmental phenols with endometriosis and uterine leiomyoma: An analysis of NHANES, 2003–2006	6
Blastocyst exposure to plastic during mice in vitro fertilization impacts placental development	6
Alcohol induces p53-mediated apoptosis in neural crest by stimulating an AMPK-mediated suppression of TORC1, S6K, and ribosomal biogenesis	6
Reproductive Toxicology: Special Edition of the 50th European Teratology Society (ETS) Meeting 2022	6
Molecular insights into the antioxidative and anti-inflammatory effects of P-coumaric acid against bisphenol A-induced testicular injury: In vivo and in silico studies	6
Lack of direct bone effect of tofacitinib, a JAK inhibitor, in juvenile rats and evaluation of the association between offspring growth and femur length	6
Emerging organoid models to study the epididymis in male reproductive toxicology	6
Editorial – Special issue: Environmental chemicals and the mammary gland	6
Evaluation of the maternal and developmental toxicity of 6-methylmercaptopurine riboside in rats	6
Smoking during pregnancy is associated with the placental proteome	6
1-(N-methyl-N-nitrosamino)-1-(3-pyridinyl)-4-butanal exposure induces testicular toxicity in male mice	6
Adding a ketogenic dietary intervention to IVF treatment in patients with polycystic ovary syndrome improves implantation and pregnancy	6
Maternal dietary intake among alcohol-exposed pregnancies is linked to early infant physical outcomes in South Africa	6
Melatonin-mediated actions and circadian functions that improve implantation, fetal health and pregnancy outcome	6
Cobalt's role in modulating antioxidant systems and semen quality in males	6
Endocrine disruptors and endometriosis	6
Impact of GSTT1 AND GSTM1 variants and hair mercury concentration in maternal blood pressure among coastal pregnant women in Central Java, Indonesia	6
Toxicity of cerium oxide nanoparticles on neonatal testicular development in mouse organ culture	6
Perfluorooctanoic acid induces cell death in TM3 cells via the ER stress-mitochondrial apoptosis pathway	6
Identification of endocrine disrupting chemicals targeting NTD-related hub genes during pregnancy via in silico analysis	6
Parabens effects on female reproductive health – Review of evidence from epidemiological and rodent-based studies	6
Upscaling biological complexity to boost neuronal and oligodendroglia maturation and improve in vitro developmental neurotoxicity (DNT) evaluation	6
Maternal obesity increases DNA methylation and decreases RNA methylation in the human placenta	6
Pubertal sexual development and endpoints for disrupted spermatogenesis in the model Xenopus tropicalis	6
Protective effect of Chlorella vulgaris on testicular damage, sperm parameters, androgen production, apoptosis and oxidative stress index in male rats following doxorubicin administration	6
AKT/mTOR-mediated autophagic signaling is associated with TCDD-induced cleft palate	6
Prenatal exposure to corn oil, CMC-Na or DMSO affects physical development and multi-organ functions in fetal mice	6
Effect of 4-nonylphenol (4-NP) on sperm function: Insights into the PI3K/PDK1/AKT signaling pathway during capacitation	6
Evaluation of a rapid, generic human gestational dose model	6
Impact of the environmental endocrine disruptor flutamide on cryptorchidism: Molecular mechanisms involving connexin-43 and p38-MAPK signaling	6
Glyphosate exposure and preterm birth: A nested case-control pilot study	6
The associations between prenatal plastic phthalate exposure and lipid acylcarnitine levels in humans and mice	6
Beauvericin disrupts G2/M transition and induces meiotic arrest during mouse oocyte maturation	6
Assessing microplastics as a novel threat to maternal-fetal health: Placental barrier penetration and fetal developmental consequences	6
In vivo and in vitro short-term bisphenol A exposures disrupt testicular energy metabolism and negatively impact spermatogenesis in zebrafish	6
TERT's protective effect on trophoblast cells: Reducing mitochondrial ROS	6
DEHP and its metabolite MEHP exposure impairs endometrial decidualization during early pregnancy via up-regulation of Mtmr6	6
A quick and laidback way to detect the internal structure of the Drosophila eye: An alternative to cryosectioning	6
Use of leflunomide among girls and women of childbearing age and occurrence of leflunomide-exposed pregnancies in Germany	6
Editorial Board	6