Genes & Development

Article	Citations
NDF is a transcription factor that stimulates elongation by RNA polymerase II	185
Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling	139
A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels	129
RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity	108
The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination	78
RUNX1 is required in granulocyte–monocyte progenitors to attenuate inflammatory cytokine production by neutrophils	76
A nonneural miRNA cluster mediates hearing via repression of two neural targets	71
WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma	60
Timing is everything: transcription bursting in development	56
ALL-tRNAseq enables robust tRNA profiling in tissue samples	51
CDK4loss-of-function mutations cause microcephaly and short stature	50
Notch induces transcription by stimulating release of paused RNA polymerase II	49
The evolving tale of Pol2 function	48
Corrigendum: Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells	48
RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription	46
How do genomes encode developmental time?	46
Oct4 redox sensitivity potentiates reprogramming and differentiation	44
Metabolic partitioning in the brain and its hijacking by glioblastoma	44
Dorsal determinant Hwa stabilizes β-catenin through direct inhibition of GSK3	41
Cohesin in 3D: development, differentiation, and disease	41
Minding the message: tactics controlling RNA decay, modification, and translation in virus-infected cells	40
Letters to the Editor	39
Rap1 regulates TIP60 function during fate transition between two-cell-like and pluripotent states	39
USP7 substrates identified by proteomics analysis reveal the specificity of USP7	39
Histone bivalency regulates the timing of cerebellar granule cell development	38

A nuclear architecture screen in Drosophila identifies Stonewall as a link between chromatin position at the nuclear periphery and germline stem cell fate	38
Recognition of acetylated histone by Yaf9 regulates metabolic cycling of transcription initiation and chromatin regulatory factors	37
The evolution of metazoan shelterin	36
Proteomic insights into circadian transcription regulation: novel E-box interactors revealed by proximity labeling	35
Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies	35
Corrigendum: Identification of a PTEN-regulated STAT3brain tumor suppressor pathway	35
Two unrelated distal genes activated by a shared enhancer benefit from localizing inside the same small topological domain	34
Tolerance thresholds underlie responses to DNA damage during germline development	34
Opening the window for endothelial-to-hematopoietic transition	34
LINE-1, the NORth star of nucleolar organization	34
ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy	34
H3K9 trimethylation in active chromatin restricts the usage of functional CTCF sites in SINE B2 repeats	33
TBX2 controls a proproliferative gene expression program in melanoma	32
Ribosome association inhibits stress-induced gene mRNA localization to stress granules	31
E3 ligase substrate adaptor SPOP fine-tunes the UPR of pancreatic β cells	30
Cancer neuroscience at the brain–body interface	28
How Terri Grodzicker transformedGenes & Development	28
Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma	27
An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma	26
PROSER1 modulates DNA demethylation through dual mechanisms to prevent syndromic developmental malformations	26
Deciphering visceral instincts: a scientific quest to unravel food choices from molecules to mind	25
Mitochondria dysfunction: cause or consequence of physiologic aging?	25
BMAL1 drives muscle repair through control of hypoxic NAD+ regeneration in satellite cells	24
Reflections on Terri	22
Multifaceted role of the vitamin B6 pathway in cancer: metabolism, immune interaction, and temporal and spatial regulation	22
Traveling with Terri: bacterial communities	22
End of the line: a kinetic ruler model for poly(A) tail termination	21
Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR	21
Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function	21
A cell type-specific surveillance complex represses cryptic promoters during differentiation in an adult stem cell lineage	21
Parental histone deposition on the replicated strands promotes error-free DNA damage tolerance and regulates drug resistance	20
An intrinsically disordered region of Drosha selectively promotes miRNA biogenesis independent of tissue-specific Microprocessor condensates	20
NEAT1 promotes genome stability via m6A methylation-dependent regulation of CHD4	20
Multiomics analysis of the NAD+–PARP1 axis reveals a role for site-specific ADP-ribosylation in splicing in embryonic stem cells	20
Corrigendum: Maternal Eed knockout causes loss of H3K27me3 imprinting and random X inactivation in the extraembryonic cells	20
TG andG&D: some thoughts and reminiscences	19
RBBP6 activates the pre-mRNA 3′ end processing machinery in humans	19
ssDNA is an allosteric regulator of the C. crescentus SOS-independent DNA damage response transcription activator, DriD	19
Noncatalytic regulation of 18SrRNA methyltransferase DIMT1 in acute myeloid leukemia	18
Corrigendum: Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity	18
H3K4me3 amplifies transcription at intergenic active regulatory elements	18
An Editor's rave review	18
Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins	17
A germline PAF1 paralog complex ensures cell type-specific gene expression	17
BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality	17
Mice carrying the homologous human shelterin POT1-L259S mutation linked to pulmonary fibrosis show a telomerase deficiency-like phenotype with telomere shortening with increasing mouse generations	17
Corrigendium: Effects of RAS on the genesis of embryonal rhabdomyosarcoma	17
Introduction: 35 years on	17
Transcription factors specifically control change	17
Therapeutic targeting of RNA for neurological and neuromuscular disease	17

Longevity-promoting mitochondrial unfolded protein response activation requires elements of the PeBoW complex	16
Circadian de(regulation) in physiology: implications for disease and treatment	16
Corrigendum: FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity	16
Rewiring gene circuits to dissect oscillatory signaling dynamics	16
Advancing therapeutics using antibody-induced dimerization of receptor tyrosine phosphatases	16
Spore germination: Two ion channels are better than one	15
From fat to fear: how lipid powers cancer spread	15
The exon junction complex coordinates the cotranscriptional inclusion of blocks of neighboring exons	15
The area postrema: a critical mediator of brain–body interactions	15
Transcription quality control at the promoter-proximal checkpoint	15
Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype	15
IRX2 and NPTX1 differential regulation of β-catenin underlies MEK-mediated proliferation in human neuroglial cells	15
MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis	15
Guide RNA acrobatics: the one-for-two shuffle	14
The inner workings of replisome-dependent control of DNA damage tolerance	14
Aging is growing up: celebrating the latest research in aging and senescence biology	14
SPOC domain proteins in health and disease	14
Bridging brain and body in cancer	14
Corrigendum: Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma	14
The MYC–MAF–SAGA axis drives oncogenic gene expression in multiple myeloma	14
Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication	14
Genetic cold cases: lessons from solving complex congenital limb disorders	14
SpoVAF and FigP assemble into oligomeric ion channels that enhance spore germination	13
Distinct accessory roles ofArabidopsisVEL proteins in Polycomb silencing	13
A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer	12
The lncRNAMalat1is trafficked to the cytoplasm as a localized mRNA encoding a small peptide in neurons	12
LINE1 elements at distal junctions of rDNA repeats regulate nucleolar organization in human embryonic stem cells	12
Chromosome organization by fine-tuning an ATPase	12
Characterization of the SF3B1–SUGP1 interface reveals how numerous cancer mutations cause mRNA missplicing	12
Restrictor slows RNAPII elongation to promote termination at noncoding RNA loci	12
Terri Grodzicker: the quintessential scientist–Editor	12
Fatty acid uptake activates an AXL–CAV1–β-catenin axis to drive melanoma progression	12
Highly rigid H3.1/H3.2–H3K9me3 domains set a barrier for cell fate reprogramming in trophoblast stem cells	12
Pioneer factor ASCL1 cooperates with the mSWI/SNF complex at distal regulatory elements to regulate human neural differentiation	12
Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation	12
Genes and my development	12
Transcriptional regulation and chromatin architecture maintenance are decoupled functions at the Sox2 locus	12
Pan-cellular organelles and suborganelles—from common functions to cellular diversity?	12
Condensation of human OAS proteins initiates diverse antiviral activities in response to West Nile virus	11
DNA repair defects in cancer and therapeutic opportunities	11
Macrophages facilitate peripheral nerve regeneration by organizing regeneration tracks through Plexin-B2	11
Structure and DNA-bridging activity of the essential Rec114–Mei4 trimer interface	11
Diverse influences on tau aggregation and implications for disease progression	10
Classifying the molecular functions of transcription factors beyond activation and repression	10
The ribosome-associated quality control factor TCF25 imposes K48 specificity on Listerin-mediated ubiquitination of nascent chains by binding and specifically orienting the acceptor ubiquitin	10
Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance	10
Igf2 regulates early postnatal DPP4+ preadipocyte pool expansion	10
Guide RNA acrobatics: positioning consecutive uridines for pseudouridylation by H/ACA pseudouridylation loops with dual guide capacity	10
Selective regulation of a defined subset of inflammatory and immunoregulatory genes by an NF-κB p50–IκBζ pathway	10
A serine metabolic enzyme is flexing its muscle to help repair skeletal muscle	10
Beyond the usual suspects: expanding aging research from classic models to really cool critters	10
A germline point mutation in the MYC-FBW7 phosphodegron initiates hematopoietic malignancies	10
Corrigendum: In vivo CRISPR screening for phenotypic targets of the mir-35-42 family in C. elegans	9
Drosha: a new tumor suppressor in pineoblastoma	9
Corrigendum: The evolutionary turnover of recombination hot spots contributes to speciation in mice	9
Chronic interferon-stimulated gene transcription promotes oncogene-induced breast cancer	9
Opposing lineage specifiers induce a protumor hybrid identity state in lung adenocarcinoma	8
Consolidating roles of neuroimmune reflexes: specificity of afferent, central, and efferent signals in homeostatic immune networks	8
Decoding biology with massively parallel reporter assays and machine learning	8
The transcription factor SRF regulates MERVL retrotransposons and gene expression during zygotic genome activation	8
Xrn2 substrate mapping identifies torpedo loading sites and extensive premature termination of RNA pol II transcription	8
TEAD switches interacting partners along neural progenitor lineage progression to execute distinct functions	8
Making a journal great: an ode to Terri Grodzicker	8
DIO3 coordinates photoreceptor development timing and fate stability in human retinal organoids	8
DiverseFgfr1signaling pathways and endocytic trafficking regulate mesoderm development	8
ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington's disease	7
What a wonderful world!	7
Coming in from the cold: overcoming the hostile immune microenvironment of medulloblastoma	7
Molecular and cellular dynamics of squamous cell carcinomas across tissues	7
Terri Grodzicker and the making ofGenes & Development	7
Killing SCLC: insights into how to target a shapeshifting tumor	6
CST–Polα/Primase: the second telomere maintenance machine	6
Histone bivalency in CNS development	6
Corrigendum: miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma	6
The Rbfox1/LASR complex controls alternative pre-mRNA splicing by recognition of multipart RNA regulatory modules	6
Letter to the Editor	6
YTHDC2 control of gametogenesis requires helicase activity but not m6A binding	6
Oct4:Sox2 binding is essential for establishing but not maintaining active and silent states of dynamically regulated genes in pluripotent cells	6
Studying ovarian aging and its health impacts: modern tools and approaches	6
Analysis of theDrosophilaand human DPR elements reveals a distinct human variant whose specificity can be enhanced by machine learning	6

Where and why have so many metabolic enzymes gone from developing spores ofBacillus subtilis?	6
Hyd/UBR5 defines a tumor suppressor pathway that links Polycomb repressive complex to regulated protein degradation in tissue growth control and tumorigenesis	5
Putting a finger on histidine methylation	5
Designer genes courtesy of artificial intelligence	5
Translating recent advances in the pathogenesis of acute myeloid leukemia to the clinic	5
Terri Grodzicker: Editor, leader, and friend	5
HeterozygousRPA2variant as a novel genetic cause of telomere biology disorders	5
Beyond rRNA: nucleolar transcription generates a complex network of RNAs with multiple roles in maintaining cellular homeostasis	5
The two faces of MyoD: repressor and activator of gene expression during myogenesis	5
The steroid hormone ADIOL promotes learning by reducing neural kynurenic acid levels	5
Synchronization of the segmentation clock using synthetic cell–cell signaling	4
Terri Grodzicker: advocate and influencer of impactful science	4
Leukemia mutated proteins PHF6 and PHIP form a chromatin complex that represses acute myeloid leukemia stemness	4
“Undruggable KRAS”: druggable after all	4
An Editor scientists dream of	4
NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation	4
Adaptation to spindle assembly checkpoint inhibition through the selection of specific aneuploidies	4
Primary cilia control translation and the cell cycle in medulloblastoma	4
Sex-specific transcriptome dynamics of Anopheles gambiae during embryonic development	4
Transcription factor networks link B-lymphocyte development and malignant transformation in leukemia	4
Tandemly repeated genes promote RNAi-mediated heterochromatin formation via an antisilencing factor, Epe1, in fission yeast	4
Imaging the binding of MECP2 to DNA	4
Cancer mortality and senescence: Is redox therapy an option?	4
Mouse cortical cellular diversification through lineage progression of radial glia	4
TRF1 uses a noncanonical function of TFIIH to promote telomere replication	4
Folding makes an imprint	3
Terri Grodzicker and her guidance through the elegance of adenovirus genetics	3
An FGF timer for zygotic genome activation	3
Aneuploidy generates enhanced nucleotide dependency and sensitivity to metabolic perturbation	3
Comparing the roles of sex chromosome-encoded protein homologs in gene regulation	3
Noncanonical imprinting sustains embryonic development and restrains placental overgrowth	3
YY1 knockout in pro-B cells impairs lineage commitment, enabling unusual hematopoietic lineage plasticity	3
Terri Grodzicker: 35 years of shaping scientific publishing and communication	3
Dynamic nucleosome remodeling mediated by YY1 underlies early mouse development	3
My pearl anniversary withGenes & Development,30 years on…	3
The microRNA-183/96/182 cluster inhibits lung cancer progression and metastasis by inducing an interleukin-2-mediated antitumor CD8+ cytotoxic T-cell response	3
The transcription factor activity gradient (TAG) model: contemplating a contact-independent mechanism for enhancer–promoter communication	3
HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation	3
MYC acetylated lysine residues drive oncogenic cell transformation and regulate select genetic programs for cell adhesion-independent growth and survival	3
Nuclear mRNPs are compact particles packaged with a network of proteins promoting RNA–RNA interactions	3
Balancing act of a leading strand DNA polymerase-specific domain and its exonuclease domain promotes genome-wide sister replication fork symmetry	3
Functional interaction between the RNA exosome and the sirtuin deacetylase Hst3 maintains transcriptional homeostasis	3
Totipotency, development, and chromatin	3
A developmental mechanism to regulate alternative polyadenylation in an adult stem cell lineage	3
ESRP2–microRNA-122 axis promotes the postnatal onset of liver polyploidization and maturation	3
The interplay between senescence, inflammation, and the immune system	3
Structural and biochemical analyses of the nuclear IκBζ protein in complex with the NF-κB p50 homodimer	3
Modeling YAP fusions: a paradigm for investigating rare cancers?	3
Allelic chromatin structure precedes imprinted expression ofKcnk9during neurogenesis	3
In vitro reconstitution of SARS-CoV-2 Nsp1-induced mRNA cleavage reveals the key roles of the N-terminal domain of Nsp1 and the RRM domain of eIF3g	3
Roles of vimentin in health and disease	3