Genes & Development

Article	Citations
Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling	200
A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels	151
A nonneural miRNA cluster mediates hearing via repression of two neural targets	115
ALL-tRNAseq enables robust tRNA profiling in tissue samples	84
NDF is a transcription factor that stimulates elongation by RNA polymerase II	81
The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination	66
RUNX1 is required in granulocyte–monocyte progenitors to attenuate inflammatory cytokine production by neutrophils	59
Timing is everything: transcription bursting in development	54
RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity	54
WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma	53
CDK4loss-of-function mutations cause microcephaly and short stature	51
The evolving tale of Pol2 function	49
Corrigendum: Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells	49
Dorsal determinant Hwa stabilizes β-catenin through direct inhibition of GSK3	46
Cohesin in 3D: development, differentiation, and disease	45
Minding the message: tactics controlling RNA decay, modification, and translation in virus-infected cells	43
How do genomes encode developmental time?	41
RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription	41
Hunchback functions in the postmitotic larval MDN to restrict axon outgrowth, synapse formation, and backward locomotion	41
Transcriptional derepression of negative regulators of MAP kinase supports maintenance of diapause ES cells in the pluripotent state	40
Metabolic partitioning in the brain and its hijacking by glioblastoma	40
Notch induces transcription by stimulating release of paused RNA polymerase II	39
Oct4 redox sensitivity potentiates reprogramming and differentiation	39
Letters to the Editor	36
Rap1 regulates TIP60 function during fate transition between two-cell-like and pluripotent states	36

A nuclear architecture screen in Drosophila identifies Stonewall as a link between chromatin position at the nuclear periphery and germline stem cell fat	36
USP7 substrates identified by proteomics analysis reveal the specificity of USP7	36
Histone bivalency regulates the timing of cerebellar granule cell development	35
Corrigendum: Identification of a PTEN-regulated STAT3brain tumor suppressor pathway	34
Tolerance thresholds underlie responses to DNA damage during germline development	34
LINE-1, the NORth star of nucleolar organization	34
Proteomic insights into circadian transcription regulation: novel E-box interactors revealed by proximity labeling	32
Two unrelated distal genes activated by a shared enhancer benefit from localizing inside the same small topological domain	31
Mutant p53: evolving perspectives	31
Ribosome association inhibits stress-induced gene mRNA localization to stress granules	29
ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy	28
H3K9 trimethylation in active chromatin restricts the usage of functional CTCF sites in SINE B2 repeats	28
Deciphering visceral instincts: a scientific quest to unravel food choices from molecules to mind	27
How Terri Grodzicker transformedGenes & Development	27
E3 ligase substrate adaptor SPOP fine-tunes the UPR of pancreatic β cells	27
Mitochondria dysfunction: cause or consequence of physiologic aging?	26
An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma	25
PROSER1 modulates DNA demethylation through dual mechanisms to prevent syndromic developmental malformations	23
BMAL1 drives muscle repair through control of hypoxic NAD+ regeneration in satellite cells	23
Reflections on Terri	22
Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma	22
Traveling with Terri: bacterial communities	22
Cancer neuroscience at the brain–body interface	22
End of the line: a kinetic ruler model for poly(A) tail termination	21
Corrigendum: Maternal Eed knockout causes loss of H3K27me3 imprinting and random X inactivation in the extraembryonic cells	21
A cell type-specific surveillance complex represses cryptic promoters during differentiation in an adult stem cell lineage	21
An intrinsically disordered region of Drosha selectively promotes miRNA biogenesis independent of tissue-specific Microprocessor condensates	21
Mutant p53 binds and controls estrogen receptor activity to drive endocrine resistance in ovarian cancer	20
Multifaceted role of the vitamin B6 pathway in cancer: metabolism, immune interaction, and temporal and spatial regulation	20
ssDNA is an allosteric regulator of the C. crescentus SOS-independent DNA damage response transcription activator, DriD	19
NEAT1 promotes genome stability via m 6 A methylation-dependent regulation of CHD4	19
Multiomics analysis of the NAD+–PARP1 axis reveals a role for site-specific ADP-ribosylation in splicing in embryonic stem cells	19
Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function	19
RBBP6 activates the pre-mRNA 3′ end processing machinery in humans	19
Parental histone deposition on the replicated strands promotes error-free DNA damage tolerance and regulates drug resistance	19
Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR	18
A germline PAF1 paralog complex ensures cell type-specific gene expression	18
An Editor's rave review	18
Noncatalytic regulation of 18SrRNA methyltransferase DIMT1 in acute myeloid leukemia	18
TG andG&D: some thoughts and reminiscences	18
Corrigendum: Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity	18
Corrigendium: Effects of RAS on the genesis of embryonal rhabdomyosarcoma	17
Introduction: 35 years on	17
Transcription factors specifically control change	17
Therapeutic targeting of RNA for neurological and neuromuscular disease	17
H3K4me3 amplifies transcription at intergenic active regulatory elements	17
Mice carrying the homologous human shelterin POT1-L259S mutation linked to pulmonary fibrosis show a telomerase deficiency-like phenotype with telomere shortening with increasing mouse generations	17
Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins	17
Spore germination: Two ion channels are better than one	16
Longevity-promoting mitochondrial unfolded protein response activation requires elements of the PeBoW complex	16

The area postrema: a critical mediator of brain–body interactions	16
Corrigendum: FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity	16
IRX2 and NPTX1 differential regulation of β-catenin underlies MEK-mediated proliferation in human neuroglial cells	15
The exon junction complex coordinates the cotranscriptional inclusion of blocks of neighboring exons	15
From fat to fear: how lipid powers cancer spread	15
Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype	15
Advancing therapeutics using antibody-induced dimerization of receptor tyrosine phosphatases	15
Rewiring gene circuits to dissect oscillatory signaling dynamics	15
Guide RNA acrobatics: the one-for-two shuffle	15
SPOC domain proteins in health and disease	15
Transcription quality control at the promoter-proximal checkpoint	14
MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis	14
BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality	14
Circadian de(regulation) in physiology: implications for disease and treatment	14
Genetic cold cases: lessons from solving complex congenital limb disorders	13
The inner workings of replisome-dependent control of DNA damage tolerance	13
Distinct accessory roles ofArabidopsisVEL proteins in Polycomb silencing	13
Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation	13
Corrigendum: Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma	13
Bridging brain and body in cancer	13
SpoVAF and FigP assemble into oligomeric ion channels that enhance spore germination	13
Aging is growing up: celebrating the latest research in aging and senescence biology	13
The MYC–MAF–SAGA axis drives oncogenic gene expression in multiple myeloma	13
Restrictor slows RNAPII elongation to promote termination at noncoding RNA loci	13
The lncRNA Malat1 is trafficked to the cytoplasm as a localized mRNA encoding a small peptide in neurons	12
LINE1 elements at distal junctions of rDNA repeats regulate nucleolar organization in human embryonic stem cells	12
Fatty acid uptake activates an AXL–CAV1–β-catenin axis to drive melanoma progression	12
Transcriptional regulation and chromatin architecture maintenance are decoupled functions at the Sox2 locus	12
Terri Grodzicker: the quintessential scientist–Editor	12
Highly rigid H3.1/H3.2–H3K9me3 domains set a barrier for cell fate reprogramming in trophoblast stem cells	12
Intrinsically disordered regions stimulate concentration of small nucleolar ribonucleoproteins and formation of Cajal bodies and nucleoli	12
Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication	12
Genes and my development	12
Pioneer factor ASCL1 cooperates with the mSWI/SNF complex at distal regulatory elements to regulate human neural differentiation	12
DNA repair defects in cancer and therapeutic opportunities	11
Pan-cellular organelles and suborganelles—from common functions to cellular diversity?	11
Structure and DNA-bridging activity of the essential Rec114–Mei4 trimer interface	11
Beyond the usual suspects: expanding aging research from classic models to really cool critters	11
Characterization of the SF3B1–SUGP1 interface reveals how numerous cancer mutations cause mRNA missplicing	11
Condensation of human OAS proteins initiates diverse antiviral activities in response to West Nile virus	11
A serine metabolic enzyme is flexing its muscle to help repair skeletal muscle	11
Chromosome organization by fine-tuning an ATPase	11
Macrophages facilitate peripheral nerve regeneration by organizing regeneration tracks through Plexin-B2	11
Selective regulation of a defined subset of inflammatory and immunoregulatory genes by an NF-κB p50–IκBζ pathway	10
Chronic interferon-stimulated gene transcription promotes oncogene-induced breast cancer	10
Drosha: a new tumor suppressor in pineoblastoma	10
A germline point mutation in the MYC-FBW7 phosphodegron initiates hematopoietic malignancies	10
The ribosome-associated quality control factor TCF25 imposes K48 specificity on Listerin-mediated ubiquitination of nascent chains by binding and specifically orienting the acceptor ubiquitin	9
Diverse influences on tau aggregation and implications for disease progression	9
Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance	9
Igf2 regulates early postnatal DPP4 + preadipocyte pool expansion	9
Opposing lineage specifiers induce a protumor hybrid identity state in lung adenocarcinoma	8
Consolidating roles of neuroimmune reflexes: specificity of afferent, central, and efferent signals in homeostatic immune networks	8
Corrigendum: The evolutionary turnover of recombination hot spots contributes to speciation in mice	8
TEAD switches interacting partners along neural progenitor lineage progression to execute distinct functions	8
DIO3 coordinates photoreceptor development timing and fate stability in human retinal organoids	8
Making a journal great: an ode to Terri Grodzicker	8
Diverse Fgfr1 signaling pathways and endocytic trafficking regulate mesoderm development	8
Classifying the molecular functions of transcription factors beyond activation and repression	8
ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington's disease	7
Coming in from the cold: overcoming the hostile immune microenvironment of medulloblastoma	7
What a wonderful world!	7
The transcription factor SRF regulates MERVL retrotransposons and gene expression during zygotic genome activation	7
Xrn2 substrate mapping identifies torpedo loading sites and extensive premature termination of RNA pol II transcription	7
Terri Grodzicker and the making ofGenes & Development	7
Decoding biology with massively parallel reporter assays and machine learning	7
Corrigendum: miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma	6
CST–Polα/Primase: the second telomere maintenance machine	6
The two faces of MyoD: repressor and activator of gene expression during myogenesis	6
Letter to the Editor	6
The LINC complex component Kms1 and CENP-B protein Cbp1 cooperate to enforce faithful homology-directed DNA repair at the nuclear periphery in S. pombe	6
Studying ovarian aging and its health impacts: modern tools and approaches	6
Where and why have so many metabolic enzymes gone from developing spores ofBacillus subtilis?	6
Oct4:Sox2 binding is essential for establishing but not maintaining active and silent states of dynamically regulated genes in pluripotent cells	6
Molecular and cellular dynamics of squamous cell carcinomas across tissues	6
The Rbfox1/LASR complex controls alternative pre-mRNA splicing by recognition of multipart RNA regulatory modules	6
Killing SCLC: insights into how to target a shapeshifting tumor	6
Beyond rRNA: nucleolar transcription generates a complex network of RNAs with multiple roles in maintaining cellular homeostasis	5
Translating recent advances in the pathogenesis of acute myeloid leukemia to the clinic	5
Designer genes courtesy of artificial intelligence	5

HeterozygousRPA2variant as a novel genetic cause of telomere biology disorders	5
Histone bivalency in CNS development	5
Corrigendum: Sept4 /ARTS is required for stem cell apoptosis and tumor suppression	5
Terri Grodzicker: Editor, leader, and friend	5
Analysis of theDrosophilaand human DPR elements reveals a distinct human variant whose specificity can be enhanced by machine learning	5
YTHDC2 control of gametogenesis requires helicase activity but not m6A binding	5
Hyd/UBR5 defines a tumor suppressor pathway that links Polycomb repressive complex to regulated protein degradation in tissue growth control and tumorigenesis	5
Putting a finger on histidine methylation	5
Adaptation to spindle assembly checkpoint inhibition through the selection of specific aneuploidies	4
Synchronization of the segmentation clock using synthetic cell–cell signaling	4
NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation	4
TRF1 uses a noncanonical function of TFIIH to promote telomere replication	4
Cancer mortality and senescence: Is redox therapy an option?	4
The steroid hormone ADIOL promotes learning by reducing neural kynurenic acid levels	4
Primary cilia control translation and the cell cycle in medulloblastoma	4
Terri Grodzicker: advocate and influencer of impactful science	4
Sex-specific transcriptome dynamics of Anopheles gambiae during embryonic development	4
An Editor scientists dream of	4
Tandemly repeated genes promote RNAi-mediated heterochromatin formation via an antisilencing factor, Epe1, in fission yeast	4
B-lineage commitment is dependent on a reversible epigenetic switch	4
Imaging the binding of MECP2 to DNA	4
Transcription factor networks link B-lymphocyte development and malignant transformation in leukemia	4
Leukemia mutated proteins PHF6 and PHIP form a chromatin complex that represses acute myeloid leukemia stemness	4
Speed of life: tuning the ticktock of the segmentation clock	3
The microRNA-183/96/182 cluster inhibits lung cancer progression and metastasis by inducing an interleukin-2-mediated antitumor CD8+ cytotoxic T-cell response	3
An FGF timer for zygotic genome activation	3
Structural and biochemical analyses of the nuclear IκBζ protein in complex with the NF-κB p50 homodimer	3
In vitro reconstitution of SARS-CoV-2 Nsp1-induced mRNA cleavage reveals the key roles of the N-terminal domain of Nsp1 and the RRM domain of eIF3g	3
MYC acetylated lysine residues drive oncogenic cell transformation and regulate select genetic programs for cell adhesion-independent growth and survival	3
Modeling YAP fusions: a paradigm for investigating rare cancers?	3
Mouse cortical cellular diversification through lineage progression of radial glia	3
Totipotency, development, and chromatin	3
Goldilocks meets Polycomb	3
A developmental mechanism to regulate alternative polyadenylation in an adult stem cell lineage	3
Harnessing brain–body communication to understand cancer	3
Comparing the roles of sex chromosome-encoded protein homologs in gene regulation	3
The interplay between senescence, inflammation, and the immune system	3
Allelic chromatin structure precedes imprinted expression ofKcnk9during neurogenesis	3
Nuclear mRNPs are compact particles packaged with a network of proteins promoting RNA–RNA interactions	3
YY1 knockout in pro-B cells impairs lineage commitment, enabling unusual hematopoietic lineage plasticity	3
Terri Grodzicker: 35 years of shaping scientific publishing and communication	3
Folding makes an imprint	3
My pearl anniversary withGenes & Development,30 years on…	3
Coupling crossover and synaptonemal complex in meiosis	3
Terri Grodzicker and her guidance through the elegance of adenovirus genetics	3
HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation	3
ESRP2–microRNA-122 axis promotes the postnatal onset of liver polyploidization and maturation	3
Balancing act of a leading strand DNA polymerase-specific domain and its exonuclease domain promotes genome-wide sister replication fork symmetry	3
Noncanonical imprinting sustains embryonic development and restrains placental overgrowth	3
Roles of vimentin in health and disease	3
“Undruggable KRAS”: druggable after all	3
Dynamic nucleosome remodeling mediated by YY1 underlies early mouse development	3
Aneuploidy generates enhanced nucleotide dependency and sensitivity to metabolic perturbation	3