Genes & Development

Article	Citations
ZFP451-mediated SUMOylation of SATB2 drives embryonic stem cell differentiation	327
Three-layered control of mRNA poly(A) tail synthesis in Saccharomyces cerevisiae	164
A nonneural miRNA cluster mediates hearing via repression of two neural targets	120
Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling	115
A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels	110
ALL-tRNAseq enables robust tRNA profiling in tissue samples	88
The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination	85
NDF is a transcription factor that stimulates elongation by RNA polymerase II	84
RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity	67
Molecular basis of mRNA transport by a kinesin-1–atypical tropomyosin complex	66
RUNX1 is required in granulocyte–monocyte progenitors to attenuate inflammatory cytokine production by neutrophils	60
WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma	58
How do genomes encode developmental time?	53
Corrigendum: Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells	52
The evolving tale of Pol2 function	50
Cohesin in 3D: development, differentiation, and disease	49
Oct4 redox sensitivity potentiates reprogramming and differentiation	48
Notch induces transcription by stimulating release of paused RNA polymerase II	47
Metabolic partitioning in the brain and its hijacking by glioblastoma	43
Minding the message: tactics controlling RNA decay, modification, and translation in virus-infected cells	42
Recognition of acetylated histone by Yaf9 regulates metabolic cycling of transcription initiation and chromatin regulatory factors	42
CDK4loss-of-function mutations cause microcephaly and short stature	42
The biological underpinnings of therapeutic resistance in pancreatic cancer	42
RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription	42
Systematic functional characterization of antisense eRNA of protocadherin α composite enhancer	42

Letters to the Editor	41
USP7 substrates identified by proteomics analysis reveal the specificity of USP7	39
Rap1 regulates TIP60 function during fate transition between two-cell-like and pluripotent states	38
The evolution of metazoan shelterin	38
Two unrelated distal genes activated by a shared enhancer benefit from localizing inside the same small topological domain	37
Histone bivalency regulates the timing of cerebellar granule cell development	37
Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies	36
Proteomic insights into circadian transcription regulation: novel E-box interactors revealed by proximity labeling	35
Tolerance thresholds underlie responses to DNA damage during germline development	35
Opening the window for endothelial-to-hematopoietic transition	34
Corrigendum: Identification of a PTEN-regulated STAT3brain tumor suppressor pathway	34
LINE-1, the NORth star of nucleolar organization	33
Ribosome association inhibits stress-induced gene mRNA localization to stress granules	32
H3K9 trimethylation in active chromatin restricts the usage of functional CTCF sites in SINE B2 repeats	32
TBX2 controls a proproliferative gene expression program in melanoma	31
ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy	31
E3 ligase substrate adaptor SPOP fine-tunes the UPR of pancreatic β cells	31
REST is a major negative regulator of endocrine differentiation during pancreas organogenesis	30
How Terri Grodzicker transformedGenes & Development	30
PROSER1 modulates DNA demethylation through dual mechanisms to prevent syndromic developmental malformations	30
Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma	30
Implications of inhibition of Rev1 interaction with Y family DNA polymerases for cisplatin chemotherapy	29
Reflections on Terri	29
Deciphering visceral instincts: a scientific quest to unravel food choices from molecules to mind	29
BMAL1 drives muscle repair through control of hypoxic NAD+ regeneration in satellite cells	29
An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma	29
Cancer neuroscience at the brain–body interface	29
Traveling with Terri: bacterial communities	28
Multiomics analysis of the NAD+–PARP1 axis reveals a role for site-specific ADP-ribosylation in splicing in embryonic stem cells	27
ssDNA is an allosteric regulator of the C. crescentus SOS-independent DNA damage response transcription activator, DriD	26
Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR	26
Parental histone deposition on the replicated strands promotes error-free DNA damage tolerance and regulates drug resistance	26
RBBP6 activates the pre-mRNA 3′ end processing machinery in humans	26
NEAT1 promotes genome stability via m6A methylation-dependent regulation of CHD4	26
Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function	26
A germline PAF1 paralog complex ensures cell type-specific gene expression	25
TG andG&D: some thoughts and reminiscences	25
An Editor's rave review	24
Anticipating resistance to KRAS inhibition: a novel role for USP21 in macropinocytosis regulation	23
Noncatalytic regulation of 18SrRNA methyltransferase DIMT1 in acute myeloid leukemia	22
Corrigendum: Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity	21
Transcription factors specifically control change	21
Corrigendium: Effects of RAS on the genesis of embryonal rhabdomyosarcoma	21
Features and mechanisms of canonical and noncanonical genomic imprinting	20
Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins	20
Therapeutic targeting of RNA for neurological and neuromuscular disease	20
Single-cell atlas reveals meningeal leukocyte heterogeneity in the developing mouse brain	20
Introduction: 35 years on	20
Advancing therapeutics using antibody-induced dimerization of receptor tyrosine phosphatases	19
BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality	19

Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype	19
Spore germination: Two ion channels are better than one	18
From fat to fear: how lipid powers cancer spread	18
Circadian de(regulation) in physiology: implications for disease and treatment	18
IRX2 and NPTX1 differential regulation of β-catenin underlies MEK-mediated proliferation in human neuroglial cells	18
The area postrema: a critical mediator of brain–body interactions	18
Genetic cold cases: lessons from solving complex congenital limb disorders	17
Guide RNA acrobatics: the one-for-two shuffle	17
Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication	17
SPOC domain proteins in health and disease	17
The MYC–MAF–SAGA axis drives oncogenic gene expression in multiple myeloma	16
Restrictor slows RNAPII elongation to promote termination at noncoding RNA loci	16
Distinct accessory roles ofArabidopsisVEL proteins in Polycomb silencing	16
SpoVAF and FigP assemble into oligomeric ion channels that enhance spore germination	16
The inner workings of replisome-dependent control of DNA damage tolerance	16
Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation	16
Bridging brain and body in cancer	16
The lncRNAMalat1is trafficked to the cytoplasm as a localized mRNA encoding a small peptide in neurons	16
Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells	16
A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer	15
The trans cell cycle effects of PARP inhibitors underlie their selectivity toward BRCA1/2-deficient cells	15
Genes and my development	15
LINE1 elements at distal junctions of rDNA repeats regulate nucleolar organization in human embryonic stem cells	15
Terri Grodzicker: the quintessential scientist–Editor	15
Fatty acid uptake activates an AXL–CAV1–β-catenin axis to drive melanoma progression	15
Pioneer factor ASCL1 cooperates with the mSWI/SNF complex at distal regulatory elements to regulate human neural differentiation	14
Targeting the m6A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication	14
Transcriptional regulation and chromatin architecture maintenance are decoupled functions at the Sox2 locus	14
Characterization of the SF3B1–SUGP1 interface reveals how numerous cancer mutations cause mRNA missplicing	14
Highly rigid H3.1/H3.2–H3K9me3 domains set a barrier for cell fate reprogramming in trophoblast stem cells	14
Chromosome organization by fine-tuning an ATPase	14
Pan-cellular organelles and suborganelles—from common functions to cellular diversity?	13
Chronic interferon-stimulated gene transcription promotes oncogene-induced breast cancer	13
DNA repair defects in cancer and therapeutic opportunities	13
Macrophages facilitate peripheral nerve regeneration by organizing regeneration tracks through Plexin-B2	13
Structure and DNA-bridging activity of the essential Rec114–Mei4 trimer interface	13
Drosha: a new tumor suppressor in pineoblastoma	12
Guide RNA acrobatics: positioning consecutive uridines for pseudouridylation by H/ACA pseudouridylation loops with dual guide capacity	12
Selective regulation of a defined subset of inflammatory and immunoregulatory genes by an NF-κB p50–IκBζ pathway	12
Classifying the molecular functions of transcription factors beyond activation and repression	12
Diverse influences on tau aggregation and implications for disease progression	12
Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance	12
A serine metabolic enzyme is flexing its muscle to help repair skeletal muscle	12
The ribosome-associated quality control factor TCF25 imposes K48 specificity on Listerin-mediated ubiquitination of nascent chains by binding and specifically orienting the acceptor ubiquitin	12
A germline point mutation in the MYC-FBW7 phosphodegron initiates hematopoietic malignancies	12
DiverseFgfr1signaling pathways and endocytic trafficking regulate mesoderm development	11
TEAD switches interacting partners along neural progenitor lineage progression to execute distinct functions	11
Disruption of origin chromatin structure by helicase activation in the absence of DNA replication	11
Corrigendum: The evolutionary turnover of recombination hot spots contributes to speciation in mice	11
Making a journal great: an ode to Terri Grodzicker	11
Decoding biology with massively parallel reporter assays and machine learning	11
The transcription factor SRF regulates MERVL retrotransposons and gene expression during zygotic genome activation	11
Corrigendum: In vivo CRISPR screening for phenotypic targets of the mir-35-42 family in C. elegans	11
ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington's disease	11
What a wonderful world!	10
Coming in from the cold: overcoming the hostile immune microenvironment of medulloblastoma	10
Corrigendum: miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma	10
Terri Grodzicker and the making ofGenes & Development	10
Xrn2 substrate mapping identifies torpedo loading sites and extensive premature termination of RNA pol II transcription	10
Molecular and cellular dynamics of squamous cell carcinomas across tissues	10
The Rbfox1/LASR complex controls alternative pre-mRNA splicing by recognition of multipart RNA regulatory modules	10
Consolidating roles of neuroimmune reflexes: specificity of afferent, central, and efferent signals in homeostatic immune networks	10
Transient genomic instability drives tumorigenesis through accelerated clonal evolution	9
Letter to the Editor	9
Killing SCLC: insights into how to target a shapeshifting tumor	9
Oct4:Sox2 binding is essential for establishing but not maintaining active and silent states of dynamically regulated genes in pluripotent cells	9
CST–Polα/Primase: the second telomere maintenance machine	9
Analysis of theDrosophilaand human DPR elements reveals a distinct human variant whose specificity can be enhanced by machine learning	9
Histone bivalency in CNS development	8
Cold-responsive adipocyte progenitors couple adrenergic signaling to immune cell activation to promote beige adipocyte accrual	8
A disproportionate impact of G9a methyltransferase deficiency on the X chromosome	8
Hyd/UBR5 defines a tumor suppressor pathway that links Polycomb repressive complex to regulated protein degradation in tissue growth control and tumorigenesis	8
Divergent evolution toward sex chromosome-specific gene regulation inDrosophila	8
Where and why have so many metabolic enzymes gone from developing spores ofBacillus subtilis?	8
Beyond rRNA: nucleolar transcription generates a complex network of RNAs with multiple roles in maintaining cellular homeostasis	8
YTHDC2 control of gametogenesis requires helicase activity but not m6A binding	8
Designer genes courtesy of artificial intelligence	7
Terri Grodzicker: Editor, leader, and friend	7
HeterozygousRPA2variant as a novel genetic cause of telomere biology disorders	7
Translating recent advances in the pathogenesis of acute myeloid leukemia to the clinic	7

Putting a finger on histidine methylation	7
Tandemly repeated genes promote RNAi-mediated heterochromatin formation via an antisilencing factor, Epe1, in fission yeast	7
TRF1 uses a noncanonical function of TFIIH to promote telomere replication	6
The steroid hormone ADIOL promotes learning by reducing neural kynurenic acid levels	6
Primary cilia control translation and the cell cycle in medulloblastoma	6
An Editor scientists dream of	6
Functional interaction between the RNA exosome and the sirtuin deacetylase Hst3 maintains transcriptional homeostasis	6
Adaptation to spindle assembly checkpoint inhibition through the selection of specific aneuploidies	6
miR-200 deficiency promotes lung cancer metastasis by activating Notch signaling in cancer-associated fibroblasts	6
Terri Grodzicker: advocate and influencer of impactful science	6
NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation	6
Imaging the binding of MECP2 to DNA	6
Roles of vimentin in health and disease	5
Allelic chromatin structure precedes imprinted expression ofKcnk9during neurogenesis	5
Modeling YAP fusions: a paradigm for investigating rare cancers?	5
Genetic and biological hallmarks of colorectal cancer	5
Terri Grodzicker: 35 years of shaping scientific publishing and communication	5
USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer	5
MYC acetylated lysine residues drive oncogenic cell transformation and regulate select genetic programs for cell adhesion-independent growth and survival	5
Transcription factor networks link B-lymphocyte development and malignant transformation in leukemia	5
Noncanonical imprinting sustains embryonic development and restrains placental overgrowth	5
YY1 knockout in pro-B cells impairs lineage commitment, enabling unusual hematopoietic lineage plasticity	5
Nuclear mRNPs are compact particles packaged with a network of proteins promoting RNA–RNA interactions	5
“Undruggable KRAS”: druggable after all	5
In vitro reconstitution of SARS-CoV-2 Nsp1-induced mRNA cleavage reveals the key roles of the N-terminal domain of Nsp1 and the RRM domain of eIF3g	4
The microRNA-183/96/182 cluster inhibits lung cancer progression and metastasis by inducing an interleukin-2-mediated antitumor CD8+ cytotoxic T-cell response	4
Balancing act of a leading strand DNA polymerase-specific domain and its exonuclease domain promotes genome-wide sister replication fork symmetry	4
ESRP2–microRNA-122 axis promotes the postnatal onset of liver polyploidization and maturation	4
HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation	4
Structural and biochemical analyses of the nuclear IκBζ protein in complex with the NF-κB p50 homodimer	4
Comparing the roles of sex chromosome-encoded protein homologs in gene regulation	4
My pearl anniversary withGenes & Development,30 years on…	4
Aneuploidy generates enhanced nucleotide dependency and sensitivity to metabolic perturbation	4
Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion	4
Dynamic nucleosome remodeling mediated by YY1 underlies early mouse development	4
Totipotency, development, and chromatin	4
Folding makes an imprint	4
An FGF timer for zygotic genome activation	4
The transcription factor activity gradient (TAG) model: contemplating a contact-independent mechanism for enhancer–promoter communication	4