Genes & Development

Article	Citations
WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma	172
RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity	124
A nonneural miRNA cluster mediates hearing via repression of two neural targets	121
Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling	96
The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination	94
NDF is a transcription factor that stimulates elongation by RNA polymerase II	72
A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels	66
Timing is everything: transcription bursting in development	65
ALL-tRNAseq enables robust tRNA profiling in tissue samples	57
Three-layered control of mRNA poly(A) tail synthesis in Saccharomyces cerevisiae	51
RUNX1 is required in granulocyte–monocyte progenitors to attenuate inflammatory cytokine production by neutrophils	46
The evolving tale of Pol2 function	44
How do genomes encode developmental time?	44
Corrigendum: Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells	44
Minding the message: tactics controlling RNA decay, modification, and translation in virus-infected cells	44
Notch induces transcription by stimulating release of paused RNA polymerase II	43
Oct4 redox sensitivity potentiates reprogramming and differentiation	43
RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription	42
CDK4loss-of-function mutations cause microcephaly and short stature	42
Cohesin in 3D: development, differentiation, and disease	41
Metabolic partitioning in the brain and its hijacking by glioblastoma	40
Letters to the Editor	38
Recognition of acetylated histone by Yaf9 regulates metabolic cycling of transcription initiation and chromatin regulatory factors	38
Histone bivalency regulates the timing of cerebellar granule cell development	37
The evolution of metazoan shelterin	37

USP7 substrates identified by proteomics analysis reveal the specificity of USP7	36
Rap1 regulates TIP60 function during fate transition between two-cell-like and pluripotent states	36
Two unrelated distal genes activated by a shared enhancer benefit from localizing inside the same small topological domain	34
Systematic functional characterization of antisense eRNA of protocadherin α composite enhancer	34
Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies	34
Proteomic insights into circadian transcription regulation: novel E-box interactors revealed by proximity labeling	33
Opening the window for endothelial-to-hematopoietic transition	33
LINE-1, the NORth star of nucleolar organization	33
Corrigendum: Identification of a PTEN-regulated STAT3brain tumor suppressor pathway	33
Tolerance thresholds underlie responses to DNA damage during germline development	32
E3 ligase substrate adaptor SPOP fine-tunes the UPR of pancreatic β cells	31
How Terri Grodzicker transformedGenes & Development	31
ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy	31
TBX2 controls a proproliferative gene expression program in melanoma	31
H3K9 trimethylation in active chromatin restricts the usage of functional CTCF sites in SINE B2 repeats	31
Ribosome association inhibits stress-induced gene mRNA localization to stress granules	31
REST is a major negative regulator of endocrine differentiation during pancreas organogenesis	31
Cancer neuroscience at the brain–body interface	29
Implications of inhibition of Rev1 interaction with Y family DNA polymerases for cisplatin chemotherapy	29
Deciphering visceral instincts: a scientific quest to unravel food choices from molecules to mind	28
Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma	27
An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma	27
BMAL1 drives muscle repair through control of hypoxic NAD+ regeneration in satellite cells	26
Traveling with Terri: bacterial communities	26
PROSER1 modulates DNA demethylation through dual mechanisms to prevent syndromic developmental malformations	26
Reflections on Terri	26
Mitochondria dysfunction: cause or consequence of physiologic aging?	26
Multiomics analysis of the NAD+–PARP1 axis reveals a role for site-specific ADP-ribosylation in splicing in embryonic stem cells	24
Parental histone deposition on the replicated strands promotes error-free DNA damage tolerance and regulates drug resistance	23
Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function	23
ssDNA is an allosteric regulator of the C. crescentus SOS-independent DNA damage response transcription activator, DriD	22
Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR	22
RBBP6 activates the pre-mRNA 3′ end processing machinery in humans	22
NEAT1 promotes genome stability via m6A methylation-dependent regulation of CHD4	21
TG andG&D: some thoughts and reminiscences	21
An Editor's rave review	21
Noncatalytic regulation of 18SrRNA methyltransferase DIMT1 in acute myeloid leukemia	20
Anticipating resistance to KRAS inhibition: a novel role for USP21 in macropinocytosis regulation	20
Corrigendium: Effects of RAS on the genesis of embryonal rhabdomyosarcoma	19
A germline PAF1 paralog complex ensures cell type-specific gene expression	19
Introduction: 35 years on	19
Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins	19
Transcription factors specifically control change	19
Corrigendum: Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity	19
Advancing therapeutics using antibody-induced dimerization of receptor tyrosine phosphatases	18
Therapeutic targeting of RNA for neurological and neuromuscular disease	18
From fat to fear: how lipid powers cancer spread	18
BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality	18
Spore germination: Two ion channels are better than one	18
Guide RNA acrobatics: the one-for-two shuffle	17

Corrigendum: FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity	17
IRX2 and NPTX1 differential regulation of β-catenin underlies MEK-mediated proliferation in human neuroglial cells	17
The area postrema: a critical mediator of brain–body interactions	17
Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype	17
The MYC–MAF–SAGA axis drives oncogenic gene expression in multiple myeloma	16
SPOC domain proteins in health and disease	16
A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer	16
Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication	16
Circadian de(regulation) in physiology: implications for disease and treatment	16
The inner workings of replisome-dependent control of DNA damage tolerance	16
Genetic cold cases: lessons from solving complex congenital limb disorders	16
The lncRNAMalat1is trafficked to the cytoplasm as a localized mRNA encoding a small peptide in neurons	15
Restrictor slows RNAPII elongation to promote termination at noncoding RNA loci	15
Distinct accessory roles ofArabidopsisVEL proteins in Polycomb silencing	15
Fatty acid uptake activates an AXL–CAV1–β-catenin axis to drive melanoma progression	14
Aging is growing up: celebrating the latest research in aging and senescence biology	14
Bridging brain and body in cancer	14
Genes and my development	14
Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation	14
Terri Grodzicker: the quintessential scientist–Editor	14
SpoVAF and FigP assemble into oligomeric ion channels that enhance spore germination	14
Transcriptional regulation and chromatin architecture maintenance are decoupled functions at the Sox2 locus	13
Highly rigid H3.1/H3.2–H3K9me3 domains set a barrier for cell fate reprogramming in trophoblast stem cells	13
LINE1 elements at distal junctions of rDNA repeats regulate nucleolar organization in human embryonic stem cells	13
Chromosome organization by fine-tuning an ATPase	13
Pan-cellular organelles and suborganelles—from common functions to cellular diversity?	13
The trans cell cycle effects of PARP inhibitors underlie their selectivity toward BRCA1/2-deficient cells	13
Pioneer factor ASCL1 cooperates with the mSWI/SNF complex at distal regulatory elements to regulate human neural differentiation	13
Structure and DNA-bridging activity of the essential Rec114–Mei4 trimer interface	13
Chronic interferon-stimulated gene transcription promotes oncogene-induced breast cancer	12
Classifying the molecular functions of transcription factors beyond activation and repression	12
Macrophages facilitate peripheral nerve regeneration by organizing regeneration tracks through Plexin-B2	12
The ribosome-associated quality control factor TCF25 imposes K48 specificity on Listerin-mediated ubiquitination of nascent chains by binding and specifically orienting the acceptor ubiquitin	12
DNA repair defects in cancer and therapeutic opportunities	12
Condensation of human OAS proteins initiates diverse antiviral activities in response to West Nile virus	12
A serine metabolic enzyme is flexing its muscle to help repair skeletal muscle	12
Characterization of the SF3B1–SUGP1 interface reveals how numerous cancer mutations cause mRNA missplicing	12
Diverse influences on tau aggregation and implications for disease progression	11
Corrigendum: The evolutionary turnover of recombination hot spots contributes to speciation in mice	11
A germline point mutation in the MYC-FBW7 phosphodegron initiates hematopoietic malignancies	11
Beyond the usual suspects: expanding aging research from classic models to really cool critters	11
Selective regulation of a defined subset of inflammatory and immunoregulatory genes by an NF-κB p50–IκBζ pathway	11
Guide RNA acrobatics: positioning consecutive uridines for pseudouridylation by H/ACA pseudouridylation loops with dual guide capacity	11
Drosha: a new tumor suppressor in pineoblastoma	11
DiverseFgfr1signaling pathways and endocytic trafficking regulate mesoderm development	11
Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance	11
The transcription factor SRF regulates MERVL retrotransposons and gene expression during zygotic genome activation	10
Xrn2 substrate mapping identifies torpedo loading sites and extensive premature termination of RNA pol II transcription	10
Coming in from the cold: overcoming the hostile immune microenvironment of medulloblastoma	10
Making a journal great: an ode to Terri Grodzicker	10
Disruption of origin chromatin structure by helicase activation in the absence of DNA replication	10
Consolidating roles of neuroimmune reflexes: specificity of afferent, central, and efferent signals in homeostatic immune networks	10
Corrigendum: In vivo CRISPR screening for phenotypic targets of the mir-35-42 family in C. elegans	10
Opposing lineage specifiers induce a protumor hybrid identity state in lung adenocarcinoma	10
TEAD switches interacting partners along neural progenitor lineage progression to execute distinct functions	10
What a wonderful world!	9
Decoding biology with massively parallel reporter assays and machine learning	9
Terri Grodzicker and the making ofGenes & Development	9
Molecular and cellular dynamics of squamous cell carcinomas across tissues	9
ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington's disease	9
Oct4:Sox2 binding is essential for establishing but not maintaining active and silent states of dynamically regulated genes in pluripotent cells	8
CST–Polα/Primase: the second telomere maintenance machine	8
Letter to the Editor	8
Corrigendum: miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma	8
The Rbfox1/LASR complex controls alternative pre-mRNA splicing by recognition of multipart RNA regulatory modules	8
Analysis of theDrosophilaand human DPR elements reveals a distinct human variant whose specificity can be enhanced by machine learning	8
Killing SCLC: insights into how to target a shapeshifting tumor	8
Studying ovarian aging and its health impacts: modern tools and approaches	8
Beyond rRNA: nucleolar transcription generates a complex network of RNAs with multiple roles in maintaining cellular homeostasis	7
Tandemly repeated genes promote RNAi-mediated heterochromatin formation via an antisilencing factor, Epe1, in fission yeast	7
Hyd/UBR5 defines a tumor suppressor pathway that links Polycomb repressive complex to regulated protein degradation in tissue growth control and tumorigenesis	7
Translating recent advances in the pathogenesis of acute myeloid leukemia to the clinic	7
HeterozygousRPA2variant as a novel genetic cause of telomere biology disorders	7
YTHDC2 control of gametogenesis requires helicase activity but not m6A binding	7
Histone bivalency in CNS development	7
Terri Grodzicker: Editor, leader, and friend	7
Cold-responsive adipocyte progenitors couple adrenergic signaling to immune cell activation to promote beige adipocyte accrual	7
Where and why have so many metabolic enzymes gone from developing spores ofBacillus subtilis?	7
Adaptation to spindle assembly checkpoint inhibition through the selection of specific aneuploidies	6
Imaging the binding of MECP2 to DNA	6

Primary cilia control translation and the cell cycle in medulloblastoma	6
Designer genes courtesy of artificial intelligence	6
The steroid hormone ADIOL promotes learning by reducing neural kynurenic acid levels	6
An Editor scientists dream of	6
Putting a finger on histidine methylation	6
NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation	6
Terri Grodzicker: advocate and influencer of impactful science	6
Leukemia mutated proteins PHF6 and PHIP form a chromatin complex that represses acute myeloid leukemia stemness	5
Roles of vimentin in health and disease	5
Transcription factor networks link B-lymphocyte development and malignant transformation in leukemia	5
“Undruggable KRAS”: druggable after all	5
TRF1 uses a noncanonical function of TFIIH to promote telomere replication	5
Sex-specific transcriptome dynamics ofAnopheles gambiaeduring embryonic development	5
Cancer mortality and senescence: Is redox therapy an option?	5
Functional interaction between the RNA exosome and the sirtuin deacetylase Hst3 maintains transcriptional homeostasis	5
Terri Grodzicker: 35 years of shaping scientific publishing and communication	5
Noncanonical imprinting sustains embryonic development and restrains placental overgrowth	5
The microRNA-183/96/182 cluster inhibits lung cancer progression and metastasis by inducing an interleukin-2-mediated antitumor CD8+ cytotoxic T-cell response	4
MYC acetylated lysine residues drive oncogenic cell transformation and regulate select genetic programs for cell adhesion-independent growth and survival	4
In vitro reconstitution of SARS-CoV-2 Nsp1-induced mRNA cleavage reveals the key roles of the N-terminal domain of Nsp1 and the RRM domain of eIF3g	4
My pearl anniversary withGenes & Development,30 years on…	4
YY1 knockout in pro-B cells impairs lineage commitment, enabling unusual hematopoietic lineage plasticity	4
Dynamic nucleosome remodeling mediated by YY1 underlies early mouse development	4
Comparing the roles of sex chromosome-encoded protein homologs in gene regulation	4
Totipotency, development, and chromatin	4
Nuclear mRNPs are compact particles packaged with a network of proteins promoting RNA–RNA interactions	4
Modeling YAP fusions: a paradigm for investigating rare cancers?	4
Allelic chromatin structure precedes imprinted expression ofKcnk9during neurogenesis	4
USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer	4
HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation	3
The interplay between senescence, inflammation, and the immune system	3
Structural and biochemical analyses of the nuclear IκBζ protein in complex with the NF-κB p50 homodimer	3
ESRP2–microRNA-122 axis promotes the postnatal onset of liver polyploidization and maturation	3
CEP120-mediated KIAA0753 recruitment onto centrioles is required for timely neuronal differentiation and germinal zone exit in the developing cerebellum	3
A developmental mechanism to regulate alternative polyadenylation in an adult stem cell lineage	3
Epigenetic modulators provide a path to understanding disease and therapeutic opportunity	3
An FGF timer for zygotic genome activation	3
Balancing act of a leading strand DNA polymerase-specific domain and its exonuclease domain promotes genome-wide sister replication fork symmetry	3
Aneuploidy generates enhanced nucleotide dependency and sensitivity to metabolic perturbation	3
Uncovering a mammalian neural-specific poly(A) binding protein with unique properties	3
NFATC2IP is a mediator of SUMO-dependent genome integrity	3
Harnessing brain–body communication to understand cancer	3
Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion	3
The transcription factor activity gradient (TAG) model: contemplating a contact-independent mechanism for enhancer–promoter communication	3
Folding makes an imprint	3
Terri Grodzicker and her guidance through the elegance of adenovirus genetics	3
A synthetic KLHL20 ligand to validate CUL3KLHL20as a potent E3 ligase for targeted protein degradation	3
Goldilocks meets Polycomb	3
The dual nature of the nucleolus	3