OOIR: Observatory of International Research

Papers

(The TQCC of Genes & Development is 23. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Senescence and the SASP: many therapeutic avenues	475
Structure and mechanism of the RNA polymerase II transcription machinery	165
Genetic and biological hallmarks of colorectal cancer	157
Context-dependent functional compensation between Ythdf m⁶A reader proteins	144
Chronic tissue inflammation and metabolic disease	121
Cells of origin of lung cancers: lessons from mouse studies	106
A central role for canonical PRC1 in shaping the 3D nuclear landscape	101
Progress toward understanding chromosome silencing by Xist RNA	93
UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide	80
Roles of vimentin in health and disease	80
The transcription factor activity gradient (TAG) model: contemplating a contact-independent mechanism for enhancer–promoter communication	78
Targeting the m⁶A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication	70
Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function	70
Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation	61
TFs for TEs: the transcription factor repertoire of mammalian transposable elements	60
Alternative splicing and cancer: insights, opportunities, and challenges from an expanding view of the transcriptome	60
Interfaces between cellular responses to DNA damage and cancer immunotherapy	59
The roles and regulation of MDM2 and MDMX: it is not just about p53	58
RNA polymerase III transcription as a disease factor	57
p53 directly represses human LINE1 transposons	57
p53 tetramerization: at the center of the dominant-negative effect of mutant p53	54
Circadian hepatocyte clocks keep synchrony in the absence of a master pacemaker in the suprachiasmatic nucleus or other extrahepatic clocks	54
Comparison of tumor-associated YAP1 fusions identifies a recurrent set of functions critical for oncogenesis	49
The biological underpinnings of therapeutic resistance in pancreatic cancer	49
The trans cell cycle effects of PARP inhibitors underlie their selectivity toward BRCA1/2-deficient cells	49

Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription	49
Transient genomic instability drives tumorigenesis through accelerated clonal evolution	49
DNA repair defects in cancer and therapeutic opportunities	48
MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity	46
piRNA-mediated gene regulation and adaptation to sex-specific transposon expression in D. melanogaster male germline	45
ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs	45
Molecular structures and mechanisms of DNA break processing in mouse meiosis	45
Distinct roles of BRCA2 in replication fork protection in response to hydroxyurea and DNA interstrand cross-links	45
AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation	44
Pioneer-like factor GAF cooperates with PBAP (SWI/SNF) and NURF (ISWI) to regulate transcription	44
The inactive Dnmt3b3 isoform preferentially enhances Dnmt3b-mediated DNA methylation	44
Calcium signaling instructs NIPBL recruitment at active enhancers and promoters via distinct mechanisms to reconstruct genome compartmentalization	43
Deubiquitinase USP20 promotes breast cancer metastasis by stabilizing SNAI2	43
Hepatic transcriptional responses to fasting and feeding	42
The nuclear cap-binding complex as choreographer of gene transcription and pre-mRNA processing	41
BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome	39
Natural temperature fluctuations promote COOLAIR regulation of FLC	39
WWTR1(TAZ)-CAMTA1 gene fusion is sufficient to dysregulate YAP/TAZ signaling and drive epithelioid hemangioendothelioma tumorigenesis	39
Break-induced replication promotes fragile telomere formation	38
4E-T-bound mRNAs are stored in a silenced and deadenylated form	38
The transcription factor EGR2 is the molecular linchpin connecting STAT6 activation to the late, stable epigenomic program of alternative macrophage polarization	38
The SAGA chromatin-modifying complex: the sum of its parts is greater than the whole	37
Identification of a localized nonsense-mediated decay pathway at the endoplasmic reticulum	37
BMP signaling: at the gate between activated melanocyte stem cells and differentiation	36
Features and mechanisms of canonical and noncanonical genomic imprinting	36
Replication stress conferred by POT1 dysfunction promotes telomere relocalization to the nuclear pore	36
Collapse of the hepatic gene regulatory network in the absence of FoxA factors	36
The DNA replication fork suppresses CMG unloading from chromatin before termination	36
Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis	35
Time is of the essence: the molecular mechanisms of primary microcephaly	35
Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion	34
miR-200 deficiency promotes lung cancer metastasis by activating Notch signaling in cancer-associated fibroblasts	34
Yap/Taz promote the scavenging of extracellular nutrients through macropinocytosis	34
The missing linker: emerging trends for H1 variant-specific functions	33
Chromosome-autonomous feedback down-regulates meiotic DNA break competence upon synaptonemal complex formation	33
Interorganelle communication, aging, and neurodegeneration	33
Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells	33
Small RNAs guide histone methylation in Arabidopsis embryos	32
Widespread microRNA degradation elements in target mRNAs can assist the encoded proteins	32
ASCL1 represses a SOX9⁺ neural crest stem-like state in small cell lung cancer	32
TEX15 associates with MILI and silences transposable elements in male germ cells	32
mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression	32
ASB13 inhibits breast cancer metastasis through promoting SNAI2 degradation and relieving its transcriptional repression of YAP	31
RBBP6 activates the pre-mRNA 3′ end processing machinery in humans	31
Nutrient-dependent control of RNA polymerase II elongation rate regulates specific gene expression programs by alternative polyadenylation	31
Epitranscriptomic addition of m⁶A regulates HIV-1 RNA stability and alternative splicing	30
Sequential in cis mutagenesis in vivo reveals various functions for CTCF sites at the mouse HoxD cluster	30
The end protection problem—an unexpected twist in the tail	28
Molecular basis of mRNA transport by a kinesin-1–atypical tropomyosin complex	28
RAD21 is a driver of chromosome 8 gain in Ewing sarcoma to mitigate replication stress	28

REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumors	28
The p53-induced RNA-binding protein ZMAT3 is a splicing regulator that inhibits the splicing of oncogenic CD44 variants in colorectal carcinoma	27
SMARCB1 loss interacts with neuronal differentiation state to block maturation and impact cell stability	27
Role of 53BP1 in end protection and DNA synthesis at DNA breaks	27
Human RTEL1 associates with Poldip3 to facilitate responses to replication stress and R-loop resolution	27
The many facets of Notch signaling in breast cancer: toward overcoming therapeutic resistance	27
Distinct kinesin motors drive two types of maize neocentromeres	27
BAF subunit switching regulates chromatin accessibility to control cell cycle exit in the developing mammalian cortex	27
WWTR1(TAZ)-CAMTA1 reprograms endothelial cells to drive epithelioid hemangioendothelioma	27
Protein phosphatases in the RNAPII transcription cycle: erasers, sculptors, gatekeepers, and potential drug targets	27
Reconstitution of 3′ end processing of mammalian pre-mRNA reveals a central role of RBBP6	26
The evolution of metazoan shelterin	26
Mutant p53 in cell-cell interactions	26
miR760 regulates ATXN1 levels via interaction with its 5′ untranslated region	25
Killing SCLC: insights into how to target a shapeshifting tumor	25
A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21	25
A most formidable arsenal: genetic technologies for building a better mouse	25
YTHDC2 control of gametogenesis requires helicase activity but not m⁶A binding	25
Acute perturbation strategies in interrogating RNA polymerase II elongation factor function in gene expression	25
Autophagy in stromal fibroblasts promotes tumor desmoplasia and mammary tumorigenesis	25
SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β cells	25
Polycomb complexes redundantly maintain epidermal stem cell identity during development	25
PR-DUB preserves Polycomb repression by preventing excessive accumulation of H2Aub1, an antagonist of chromatin compaction	25
Targeted chemotherapy overcomes drug resistance in melanoma	24
The Pol II preinitiation complex (PIC) influences Mediator binding but not promoter–enhancer looping	24
Competition between maturation and degradation drives human snRNA 3′ end quality control	23
The Daam2–VHL–Nedd4 axis governs developmental and regenerative oligodendrocyte differentiation	23
Molecular principles of Piwi-mediated cotranscriptional silencing through the dimeric SFiNX complex	23