OOIR: Observatory of International Research

Papers

(The TQCC of Genes & Development is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
The transcription factor SRF regulates MERVL retrotransposons and gene expression during zygotic genome activation	304
ESRP2–microRNA-122 axis promotes the postnatal onset of liver polyploidization and maturation	146
Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins	111
Coming in from the cold: overcoming the hostile immune microenvironment of medulloblastoma	107
Making a journal great: an ode to Terri Grodzicker	103
TG andG&D: some thoughts and reminiscences	94
Totipotency, development, and chromatin	81
An Editor's rave review	81
Corrigendum: In vivo CRISPR screening for phenotypic targets of the mir-35-42 family in C. elegans	79
Corrigendium: Effects of RAS on the genesis of embryonal rhabdomyosarcoma	74
Decoding biology with massively parallel reporter assays and machine learning	70
Consolidating roles of neuroimmune reflexes: specificity of afferent, central, and efferent signals in homeostatic immune networks	64
Interoceptive inference and prediction in food-related disorders	62
Psat1-generated α-ketoglutarate and glutamine promote muscle stem cell activation and regeneration	54
Transcription factors specifically control change	53
Neural stem/precursor cells dynamically change their epigenetic landscape to differentially respond to BMP signaling for fate switching during brain development	51
Corrigendum: Defining the influence of Rad51 and Dmc1 lineage-specific amino acids on genetic recombination	51
Structural basis of PETISCO complex assembly during piRNA biogenesis in C. elegans	51
Dynamics in Fip1 regulate eukaryotic mRNA 3′ end processing	50
My pearl anniversary withGenes & Development,30 years on…	49
Regularly spaced tyrosines in EBF1 mediate BRG1 recruitment and formation of nuclear subdiffractive clusters	48
ALL-tRNAseq enables robust tRNA profiling in tissue samples	48
Molecular basis for PHF7-mediated ubiquitination of histone H3	47
Xrn2 substrate mapping identifies torpedo loading sites and extensive premature termination of RNA pol II transcription	47
Noncatalytic regulation of 18SrRNA methyltransferase DIMT1 in acute myeloid leukemia	47

Comparing the roles of sex chromosome-encoded protein homologs in gene regulation	45
Single-cell atlas reveals meningeal leukocyte heterogeneity in the developing mouse brain	42
Nopp140-chaperoned 2′-O-methylation of small nuclear RNAs in Cajal bodies ensures splicing fidelity	41
NDF is a transcription factor that stimulates elongation by RNA polymerase II	40
Three-layered control of mRNA poly(A) tail synthesis in Saccharomyces cerevisiae	40
The microRNA-183/96/182 cluster inhibits lung cancer progression and metastasis by inducing an interleukin-2-mediated antitumor CD8⁺ cytotoxic T-cell response	39
Disruption of origin chromatin structure by helicase activation in the absence of DNA replication	39
ASCL1 represses a SOX9⁺ neural crest stem-like state in small cell lung cancer	37
Unique role for lncRNA HOTAIR in defining depot-specific gene expression patterns in human adipose-derived stem cells	36
Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling	36
Localization ofKif1cmRNA to cell protrusions dictates binding partner specificity of the encoded protein	35
An FGF timer for zygotic genome activation	35
A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels	34
In vivo temporal resolution of acute promyelocytic leukemia progression reveals a role of Klf4 in suppressing early leukemic transformation	34
Major β cell-specific functions of NKX2.2 are mediated via the NK2-specific domain	34
Anticipating resistance to KRAS inhibition: a novel role for USP21 in macropinocytosis regulation	33
Folding makes an imprint	32
Hepatic GATA4 regulates cholesterol and triglyceride homeostasis in collaboration with LXRs	31
DiverseFgfr1signaling pathways and endocytic trafficking regulate mesoderm development	30
An old dog with new tricks: TFEB promotes syncytin expression and cell fusion in the human placenta	30
Corrigendum: The evolutionary turnover of recombination hot spots contributes to speciation in mice	30
Arrested development: the dysfunctional life history of medulloblastoma	30
RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity	30
Building a circuit through correlated spontaneous neuronal activity in the developing vertebrate and invertebrate visual systems	29
Structural and biochemical analyses of the nuclear IκBζ protein in complex with the NF-κB p50 homodimer	29
A nonneural miRNA cluster mediates hearing via repression of two neural targets	29
Molecular basis of mRNA transport by a kinesin-1–atypical tropomyosin complex	28
Mesenchymal stromal cells as conductors of adipose tissue remodeling	28
Corrigendum: Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity	28
A germline PAF1 paralog complex ensures cell type-specific gene expression	28
ZFP451-mediated SUMOylation of SATB2 drives embryonic stem cell differentiation	27
The transcription factor activity gradient (TAG) model: contemplating a contact-independent mechanism for enhancer–promoter communication	27
HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation	27
Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion	27
ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington's disease	26
Single-molecule identification of the target RNAs of different RNA binding proteins simultaneously in cells	26
Target-directed microRNA degradation regulates developmental microRNA expression and embryonic growth in mammals	26
Features and mechanisms of canonical and noncanonical genomic imprinting	25
Interfaces between cellular responses to DNA damage and cancer immunotherapy	25
Balancing act of a leading strand DNA polymerase-specific domain and its exonuclease domain promotes genome-wide sister replication fork symmetry	25
From fat to fear: how lipid powers cancer spread	24
The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination	24
RUNX1 is required in granulocyte–monocyte progenitors to attenuate inflammatory cytokine production by neutrophils	24
The roles and regulation of MDM2 and MDMX: it is not just about p53	24
WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma	24
You can be an editor too!	22
The dual nature of the nucleolus	22
Terri Grodzicker and the making ofGenes & Development	22
Introduction: 35 years on	22
Terri Grodzicker and her guidance through the elegance of adenovirus genetics	22

Restrictor synergizes with Symplekin and PNUTS to terminate extragenic transcription	21
CST–Polα/Primase: the second telomere maintenance machine	21
Hao-Fountain syndrome protein USP7 controls neuronal differentiation via BCOR–ncPRC1.1	21
Mutant p53 in cell-cell interactions	20
Corrigendum: Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication	19
Goldilocks meets Polycomb	19
Corrigendum: miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma	19
How do genomes encode developmental time?	19
What a wonderful world!	18
Meikin synergizes with shugoshin to protect cohesin Rec8 during meiosis I	18
Harnessing brain–body communication to understand cancer	18
The area postrema: a critical mediator of brain–body interactions	18
Transcription factor-mediated intestinal metaplasia and the role of a shadow enhancer	18
Protein phosphatases in the RNAPII transcription cycle: erasers, sculptors, gatekeepers, and potential drug targets	18
NFATC2IP is a mediator of SUMO-dependent genome integrity	18
Differential use of the Nkx2.2 NK2 domain in developing pancreatic islets and neurons	17
Spore germination: Two ion channels are better than one	17
A developmental mechanism to regulate alternative polyadenylation in an adult stem cell lineage	16
Circadian de(regulation) in physiology: implications for disease and treatment	16
BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality	16
Molecular and cellular dynamics of squamous cell carcinomas across tissues	16
Notch induces transcription by stimulating release of paused RNA polymerase II	16
Advancing therapeutics using antibody-induced dimerization of receptor tyrosine phosphatases	16
Uncovering a mammalian neural-specific poly(A) binding protein with unique properties	16
Protein phosphatase 4 controls circadian clock dynamics by modulating CLOCK/BMAL1 activity	16