OOIR: Observatory of International Research

Papers

(The TQCC of Genes & Development is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
A nonneural miRNA cluster mediates hearing via repression of two neural targets	140
Corrigendum: Fine-tuning p53 activity by modulating the interaction between eukaryotic translation initiation factor eIF4E and RNA-binding protein RBM38	105
Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling	93
A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels	92
WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma	61
RUNX1 is required in granulocyte–monocyte progenitors to attenuate inflammatory cytokine production by neutrophils	61
RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity	55
ALL-tRNAseq enables robust tRNA profiling in tissue samples	51
Timing is everything: transcription bursting in development	50
Oct4 redox sensitivity potentiates reprogramming and differentiation	48
Corrigendum: Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells	42
The evolving tale of Pol2 function	41
Cohesin in 3D: development, differentiation, and disease	40
RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription	39
How do genomes encode developmental time?	38
CDK4loss-of-function mutations cause microcephaly and short stature	35
Notch induces transcription by stimulating release of paused RNA polymerase II	35
Metabolic partitioning in the brain and its hijacking by glioblastoma	35
Transcriptional derepression of negative regulators of MAP kinase supports maintenance of diapause ES cells in the pluripotent state	34
Hunchback functions in the postmitotic larval MDN to restrict axon outgrowth, synapse formation, and backward locomotion	34
Dorsal determinant Hwa stabilizes β-catenin through direct inhibition of GSK3	33
USP7 substrates identified by proteomics analysis reveal the specificity of USP7	32
Letters to the Editor	31
A nuclear architecture screen in Drosophila identifies Stonewall as a link between chromatin position at the nuclear periphery and germline stem cell fat	30
Lights up on the embryonic dance: tools and applications of optogenetics in developmental biology	30

Histone bivalency regulates the timing of cerebellar granule cell development	29
A lncRNA drives developmentally timed decay of all members of an essential microRNA family	29
Two unrelated distal genes activated by a shared enhancer benefit from localizing inside the same small topological domain	27
Corrigendum: Identification of a PTEN-regulated STAT₃brain tumor suppressor pathway	27
The conserved N-terminal SANT1-binding domain (SBD) of EZH2 regulates PRC2 activity	26
Proteomic insights into circadian transcription regulation: novel E-box interactors revealed by proximity labeling	25
LINE-1, the NORth star of nucleolar organization	25
ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy	25
Ribosome association inhibits stress-induced gene mRNA localization to stress granules	25
Tolerance thresholds underlie responses to DNA damage during germline development	25
Mutant p53: evolving perspectives	24
Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma	24
How Terri Grodzicker transformedGenes & Development	24
Independent control of neurogenesis and dorsoventral patterning by NKX2-2	23
Deciphering visceral instincts: a scientific quest to unravel food choices from molecules to mind	23
A brain-specific microRNA, miR-1000 , regulates lipid homeostasis via neuropeptide-like precursor 1 in Drosophila melanogaster	22
An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma	22
E3 ligase substrate adaptor SPOP fine-tunes the UPR of pancreatic β cells	22
PROSER1 modulates DNA demethylation through dual mechanisms to prevent syndromic developmental malformations	22
Mitochondria dysfunction: cause or consequence of physiologic aging?	22
Rethinking HNF1A-MODY: HNF1A at the crossroads of development and multiorgan metabolic disease	21
Traveling with Terri: bacterial communities	21
Cancer neuroscience at the brain–body interface	21
Reflections on Terri	21
End of the line: a kinetic ruler model for poly(A) tail termination	20
Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR	20
Mutant p53 binds and controls estrogen receptor activity to drive endocrine resistance in ovarian cancer	20
Corrigendum: Maternal Eed knockout causes loss of H3K27me3 imprinting and random X inactivation in the extraembryonic cells	20
Multifaceted role of the vitamin B6 pathway in cancer: metabolism, immune interaction, and temporal and spatial regulation	20
Multiomic analysis of clonal development reveals new regulators of leukemic cell growth	20
A cell type-specific surveillance complex represses cryptic promoters during differentiation in an adult stem cell lineage	20
An intrinsically disordered region of Drosha selectively promotes miRNA biogenesis independent of tissue-specific Microprocessor condensates	20
NEAT1 promotes genome stability via m ⁶ A methylation-dependent regulation of CHD4	20
Corrigendum: Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity	19
Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function	19
An Editor's rave review	19
A germline PAF1 paralog complex ensures cell type-specific gene expression	19
TG andG&D: some thoughts and reminiscences	19
Mice carrying the homologous human shelterin POT1-L259S mutation linked to pulmonary fibrosis show a telomerase deficiency-like phenotype with telomere shortening with increasing mouse generations	18
Corrigendium: Effects of RAS on the genesis of embryonal rhabdomyosarcoma	18
Transcription factors specifically control change	18
Noncatalytic regulation of 18SrRNA methyltransferase DIMT1 in acute myeloid leukemia	17
Corrigendum: FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity	16
H3K4me3 amplifies transcription at intergenic active regulatory elements	16
Introduction: 35 years on	16
Therapeutic targeting of RNA for neurological and neuromuscular disease	16
Mechanisms coordinating exit from the stem cell state in mammals	16
IRX2 and NPTX1 differential regulation of β-catenin underlies MEK-mediated proliferation in human neuroglial cells	15
From fat to fear: how lipid powers cancer spread	15
The exon junction complex coordinates the cotranscriptional inclusion of blocks of neighboring exons	15

Advancing therapeutics using antibody-induced dimerization of receptor tyrosine phosphatases	15
Transcription quality control at the promoter-proximal checkpoint	15
Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype	15
Circadian de(regulation) in physiology: implications for disease and treatment	14
SPOC domain proteins in health and disease	14
Rewiring gene circuits to dissect oscillatory signaling dynamics	14
Spore germination: Two ion channels are better than one	14
Longevity-promoting mitochondrial unfolded protein response activation requires elements of the PeBoW complex	14
The area postrema: a critical mediator of brain–body interactions	13
Corrigendum: Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma	13
BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality	13
MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis	13
Aging is growing up: celebrating the latest research in aging and senescence biology	12
The lncRNA Malat1 is trafficked to the cytoplasm as a localized mRNA encoding a small peptide in neurons	12
Genetic cold cases: lessons from solving complex congenital limb disorders	12
The MYC–MAF–SAGA axis drives oncogenic gene expression in multiple myeloma	12
Restrictor slows RNAPII elongation to promote termination at noncoding RNA loci	12
Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication	11
Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation	11
Distinct accessory roles ofArabidopsisVEL proteins in Polycomb silencing	11
SpoVAF and FigP assemble into oligomeric ion channels that enhance spore germination	11
Bridging brain and body in cancer	11
Cohesin-mediated loop extrusion and enhancer-associated factors additively contribute to Sox2 looping with its distal enhancer	10
Separable roles for Microprocessor and its cofactors, ERH and SAFB1/2, during microRNA cluster assistance	10
Modeling medulloblastoma pathogenesis and treatment in human cerebellar organoids	10
Intrinsically disordered regions stimulate concentration of small nucleolar ribonucleoproteins and formation of Cajal bodies and nucleoli	10
Fatty acid uptake activates an AXL–CAV1–β-catenin axis to drive melanoma progression	10
Terri Grodzicker: the quintessential scientist–Editor	10
Genes and my development	10
Pioneer factor ASCL1 cooperates with the mSWI/SNF complex at distal regulatory elements to regulate human neural differentiation	10