OOIR: Observatory of International Research

Papers

(The TQCC of Genes & Development is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling	200
A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels	151
A nonneural miRNA cluster mediates hearing via repression of two neural targets	115
ALL-tRNAseq enables robust tRNA profiling in tissue samples	84
NDF is a transcription factor that stimulates elongation by RNA polymerase II	81
The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination	66
RUNX1 is required in granulocyte–monocyte progenitors to attenuate inflammatory cytokine production by neutrophils	59
Timing is everything: transcription bursting in development	54
RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity	54
WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma	53
CDK4loss-of-function mutations cause microcephaly and short stature	51
The evolving tale of Pol2 function	49
Corrigendum: Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells	49
Dorsal determinant Hwa stabilizes β-catenin through direct inhibition of GSK3	46
Cohesin in 3D: development, differentiation, and disease	45
Minding the message: tactics controlling RNA decay, modification, and translation in virus-infected cells	43
How do genomes encode developmental time?	41
RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription	41
Hunchback functions in the postmitotic larval MDN to restrict axon outgrowth, synapse formation, and backward locomotion	41
Transcriptional derepression of negative regulators of MAP kinase supports maintenance of diapause ES cells in the pluripotent state	40
Metabolic partitioning in the brain and its hijacking by glioblastoma	40
Notch induces transcription by stimulating release of paused RNA polymerase II	39
Oct4 redox sensitivity potentiates reprogramming and differentiation	39
Letters to the Editor	36
Rap1 regulates TIP60 function during fate transition between two-cell-like and pluripotent states	36

A nuclear architecture screen in Drosophila identifies Stonewall as a link between chromatin position at the nuclear periphery and germline stem cell fat	36
USP7 substrates identified by proteomics analysis reveal the specificity of USP7	36
Histone bivalency regulates the timing of cerebellar granule cell development	35
Corrigendum: Identification of a PTEN-regulated STAT₃brain tumor suppressor pathway	34
Tolerance thresholds underlie responses to DNA damage during germline development	34
LINE-1, the NORth star of nucleolar organization	34
Proteomic insights into circadian transcription regulation: novel E-box interactors revealed by proximity labeling	32
Two unrelated distal genes activated by a shared enhancer benefit from localizing inside the same small topological domain	31
Mutant p53: evolving perspectives	31
Ribosome association inhibits stress-induced gene mRNA localization to stress granules	29
ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy	28
H3K9 trimethylation in active chromatin restricts the usage of functional CTCF sites in SINE B2 repeats	28
Deciphering visceral instincts: a scientific quest to unravel food choices from molecules to mind	27
How Terri Grodzicker transformedGenes & Development	27
E3 ligase substrate adaptor SPOP fine-tunes the UPR of pancreatic β cells	27
Mitochondria dysfunction: cause or consequence of physiologic aging?	26
An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma	25
PROSER1 modulates DNA demethylation through dual mechanisms to prevent syndromic developmental malformations	23
BMAL1 drives muscle repair through control of hypoxic NAD⁺ regeneration in satellite cells	23
Reflections on Terri	22
Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma	22
Traveling with Terri: bacterial communities	22
Cancer neuroscience at the brain–body interface	22
End of the line: a kinetic ruler model for poly(A) tail termination	21
Corrigendum: Maternal Eed knockout causes loss of H3K27me3 imprinting and random X inactivation in the extraembryonic cells	21
A cell type-specific surveillance complex represses cryptic promoters during differentiation in an adult stem cell lineage	21
An intrinsically disordered region of Drosha selectively promotes miRNA biogenesis independent of tissue-specific Microprocessor condensates	21
Mutant p53 binds and controls estrogen receptor activity to drive endocrine resistance in ovarian cancer	20
Multifaceted role of the vitamin B6 pathway in cancer: metabolism, immune interaction, and temporal and spatial regulation	20
ssDNA is an allosteric regulator of the C. crescentus SOS-independent DNA damage response transcription activator, DriD	19
NEAT1 promotes genome stability via m ⁶ A methylation-dependent regulation of CHD4	19
Multiomics analysis of the NAD⁺–PARP1 axis reveals a role for site-specific ADP-ribosylation in splicing in embryonic stem cells	19
Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function	19
RBBP6 activates the pre-mRNA 3′ end processing machinery in humans	19
Parental histone deposition on the replicated strands promotes error-free DNA damage tolerance and regulates drug resistance	19
Corrigendum: Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity	18
Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR	18
A germline PAF1 paralog complex ensures cell type-specific gene expression	18
An Editor's rave review	18
Noncatalytic regulation of 18SrRNA methyltransferase DIMT1 in acute myeloid leukemia	18
TG andG&D: some thoughts and reminiscences	18
Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins	17
Corrigendium: Effects of RAS on the genesis of embryonal rhabdomyosarcoma	17
Introduction: 35 years on	17
Transcription factors specifically control change	17
Therapeutic targeting of RNA for neurological and neuromuscular disease	17
H3K4me3 amplifies transcription at intergenic active regulatory elements	17
Mice carrying the homologous human shelterin POT1-L259S mutation linked to pulmonary fibrosis show a telomerase deficiency-like phenotype with telomere shortening with increasing mouse generations	17
Spore germination: Two ion channels are better than one	16
Longevity-promoting mitochondrial unfolded protein response activation requires elements of the PeBoW complex	16

The area postrema: a critical mediator of brain–body interactions	16
Corrigendum: FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity	16
IRX2 and NPTX1 differential regulation of β-catenin underlies MEK-mediated proliferation in human neuroglial cells	15
The exon junction complex coordinates the cotranscriptional inclusion of blocks of neighboring exons	15
From fat to fear: how lipid powers cancer spread	15
Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype	15
Advancing therapeutics using antibody-induced dimerization of receptor tyrosine phosphatases	15
Rewiring gene circuits to dissect oscillatory signaling dynamics	15
Guide RNA acrobatics: the one-for-two shuffle	15
SPOC domain proteins in health and disease	15
BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality	14
Transcription quality control at the promoter-proximal checkpoint	14
MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis	14
Circadian de(regulation) in physiology: implications for disease and treatment	14
Aging is growing up: celebrating the latest research in aging and senescence biology	13
The MYC–MAF–SAGA axis drives oncogenic gene expression in multiple myeloma	13
Restrictor slows RNAPII elongation to promote termination at noncoding RNA loci	13
Genetic cold cases: lessons from solving complex congenital limb disorders	13
The inner workings of replisome-dependent control of DNA damage tolerance	13
Distinct accessory roles ofArabidopsisVEL proteins in Polycomb silencing	13
Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation	13
Corrigendum: Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma	13
Bridging brain and body in cancer	13
SpoVAF and FigP assemble into oligomeric ion channels that enhance spore germination	13