Immunopharmacology and Immunotoxicology

Article	Citations
In vitro anti-tumor activities of a novel recombinant immunotoxin targeting differentially overexpressed Leucine-rich repeat-containing G-protein-coupled receptor 5 in cervical canc	48
Assessing the effectiveness of camrelizumab plus anti-angiogenesis drug for the treatment of advanced liver cancer: a single‑center retrospective study	42
Inhibition of long-lived plasma cells, a critical role for Telitacicept treatment to systemic lupus erythematosus	35
Extracellular vesicle-derived LINC00511 promotes glycolysis and mitochondrial oxidative phosphorylation of pancreatic cancer through macrophage polarization by microRNA-193a-3p-dependent regulation of	28
Gastrodin ameliorates Concanavalin A-induced acute hepatitis via the IL6/JAK2/STAT3 pathway	22
Moscatilin protects concanavalin A-induced autoimmune liver disease in mice	21
Galantamine supplementation and rheumatoid arthritis: a systematic review of current research and molecular mechanisms	21
Corynoline ameliorates dextran sulfate sodium-induced colitis in mice by modulating Nrf2/NF-κB pathway	20
Beta-sitosterol alleviates inflammatory culprits and disease severity in arthritic irradiated rat’s model: role of brain-spleen axis	20
Leukoreduced PRP enhanced proliferation and ECM production yet inhibited senescence, inflammation, and multi-differentiation potential of AFSCs by downregulating HMGB1	20
Prospective therapeutic targets and recent advancements in the treatment of inflammatory bowel disease	20
Sevoflurane induces cognitive dysfunction by modulating PER2 methylation to block AKT pathway-suppressed NLRP3 inflammatory vesicle in microglia	19
Sirtinol, a SIRT1 inhibitor, inhibits the EMT and metastasis of 4T1 breast cancer cells and impacts the tumor microenvironment	19
Role of oncostatin M and its receptor in the inflammatory pathogenesis of Graves' orbitopathy	18
Monotropein alleviates acute pulmonary embolism in rats by inhibiting the NF-κB pathway	17
Neutrophil Extracellular Traps (NET) and SARS-CoV-2	17
Aryl-Cyclohexanone as a potential CB2 agonist: in vitro and in silico evidence in inflammatory modulation	16
Correction	16
Protective effect of pregabalin on renal and renal endothelial damage in sepsis induced by lipopolysaccharide	16
Withaferin A suppressed hepatocellular carcinoma progression through inducing IGF2BP3/FOXO1/JAK2/STAT3 pathway-mediated ROS production	16
Systematic review of the efficacy and safety of lenvatinib in various solid tumors	16
An overview of the current advances in the treatment of inflammatory diseases using mesenchymal stromal cell secretome	16
Cancer-associated immune cells and their modulation by melatonin	15
Dapagliflozin alleviates thioacetamide induced-liver fibrosis in rats via controlling the Nrf2/HO-1 and TLR4/TGF-β1/PI3K signaling pathways	15
Sulforaphane alleviates LPS-induced inflammatory injury in ARPE-19 cells by repressing the PWRN2/NF-kB pathway	15

Sirt1/Nrf2/TNFα; TLR4/Myd88/NF-κB signaling pathways are involved in mediating hepatoprotective effect of bupropion in rat model of myocardial infarction	15
mTORC1 inhibition may improve T lymphocytes affected by aging	15
Synergistic immunosuppressive effect of hispidulin and nepetin mixtures on human T lymphocytes	15
Immunotherapeutic potentials of carnosol against lipopolysaccharides-induced acute inflammatory reactions in White Swiss albino mice	15
Thymosin α1 improves the outcomes of patients with hepatitis B virus-related acute-on-chronic liver failure by restoring immune balance	14
LncRNA SLC16A1-AS1 regulates the miR-182/PDCD4 axis and inhibits the triple-negative breast cancer cell cycle	14
Correction	14
Losartan ameliorates premature ovarian failure by regulation of the Sirti1/NF-κB pathway in female albino rats	14
Celecoxib alleviates the DSS-induced ulcerative colitis in mice by enhancing intestinal barrier function, inhibiting ferroptosis and suppressing apoptosis	13
Hydroxychloroquine ameliorates immune functionality and intestinal flora disorders of IgA nephropathy by inhibition of C1GALT1/Cosmc pathway	13
Baicalin suppresses interleukin-1β-induced apoptosis, inflammatory response, oxidative stress, and extracellular matrix degradation in human nucleus pulposus cells	13
SDH5 down-regulation mitigates the damage of osteoporosis via inhibiting the MyD88/NF-κB signaling pathway	12
Selective and effective suppression of pancreatic cancer through MNK inhibition	12
CircRNA circ-PDCD11 is highly expressed in lung large-cell carcinoma and predicts poor survival	12
Lupeol triggers oxidative stress, ferroptosis, apoptosis and restrains inflammation in nasopharyngeal carcinoma via AMPK/NF-κB pathway	12
Molecular mechanisms mediate roflumilast protective effect against isoprenaline-induced myocardial injury	12
Investigation of the effect of IFN-γ/TNF-α-treated mesenchymal stem cells on Th9- and Treg cell-related parameters in a mouse model of ovalbumin-induced allergic asthma	12
Anticolitis effect of febuxostat. The imperative role of NLRP-3/Caspase-1/IL-1β pathway via histopathological, immunohistochemical and biochemical approach	12
The effect of Vortioxetine on the NLRP3 pathway and microglial activity in the prefrontal cortex in an experimental model of depression	11
Rituximab induces a flare-up of activated neutrophil extracellular traps under in vitro conditions	11
Association between serum baseline C1q and IgG levels and the efficacy of combined immunotherapy in patients with esophageal squamous cell carcinoma: a retrospective study	11
Astragaloside IV restores Th17/Treg balance via inhibiting CXCR4 to improve chronic obstructive pulmonary disease	11
Two flavonoids, baicalein and naringin, are effective as anti-inflammatory and anti-oxidant agents in a rat model of polymicrobial sepsis	11
Thymic stromal lymphopoietin levels after allogeneic hematopoietic stem cell transplantation	10
Glucocorticoid receptor signaling: crosstalk with inflammation	10
Cannabis sativa alleviates experimentally acetic acid- induced ulcerative colitis in rats: targeting CB1/SIRT/MAPK signaling pathways	10
Correction	9
Gigantol protects retinal pigment epithelial cells against high glucose-induced apoptosis, oxidative stress and inflammation by inhibiting MTDH-mediated NF-kB signaling pathway	9
Luteolin restored Treg/Th17 balance to ameliorate allergic rhinitis in a mouse model	9
Seasonal facial erythema in a patient with allergic rhinitis treated using a combination of tranilast and roxithromycin	9
Cardioprotective effect of tofisopam against isoprenaline-induced myocardial infarction in rats via modulation of NLRP3\IL-1β\caspase-1 pathway	9
IGF2BP3 aggravates lung adenocarcinoma progression by modulation of PI3K/AKT signaling pathway	9
Nodakenin attenuates cerebral ischemia–reperfusion injury by modulating the PI3K/AKT/NF-κB signaling pathway	9
Occupational exposure to pesticides affects systemic cytokine profile and correlates with poor clinical prognosis in young women with breast cancer	9
Forkhead box A1 induces angiogenesis through activation of the S100A8/p38 MAPK axis in cutaneous wound healing	9
Role of EGF/ERK1/2/HO-1 axis in mediating methotrexate induced testicular damage in rats and the ameliorative effect of xanthine oxidase inhibitors	9
T-cell metabolism in rheumatoid arthritis: focus on mitochondrial and lysosomal dysfunction	9
Leptin/lipopolysaccharide-treated dendritic cell vaccine improved cellular immune responses in an animal model of breast cancer	9
Expression of calcitonin gene-related peptide in atopic dermatitis and correlation with distress	9
Galectin-1-producing mesenchymal stem cells restrain the proliferation of T lymphocytes from patients with systemic lupus erythematosus	8
Evaluation of the inhibitory effect of different molecular weights chitosan on MRGPRX2-mediated mast cell degranulation and the pseudo-allergic reaction	8
Investigating the therapeutic efficacy of physical exercise on tumor immunity in a mouse model of malignant colon cancer	8
Endoplasmic reticulum stress is upregulated in inflammatory bowel disease and contributed TLR2 pathway-mediated inflammatory response	8
Decreasing REDD1 expression protects against high glucose-induced apoptosis, oxidative stress and inflammatory injury in podocytes through regulation of the AKT/GSK-3β/Nrf2 pathway	8
Time to treat the climate and nature crisis as one indivisible global health emergency	8
Impact of interleukin-32α on T helper cell-related cytokines, transcription factors, and proliferation in patients with type 2 diabetes mellitus	8
Kindlin-2 silencing promoted apoptosis and cell cycle arrest through the fas/FasL pathway in hepatocellular carcinoma	8
Prognostic values of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in the early prediction of aluminum phosphide-poisoned patients’ outcomes	8
β-Sitosterol inhibits ovalbumin-induced asthma-related inflammation by regulating dendritic cells	8
Wogonoside preserves against ischemia/reperfusion-induced myocardial injury by suppression of apoptosis, inflammation, and fibrosis via modulating Nrf2/HO-1 pathway	8

The protective effect of butylated hydroxytoluene and 3-hydroxytyrosol on food allergy in mice	7
Safety assessment of voclosporin: a real-world disproportionality analysis of the FAERS database	7
The anti-inflammatory effects of vitamin B6 on neuroinflammation and neuronal damage caused by 1,2-diacetylbenzene in BV2 microglial and sH-SY5Y cells	7
Therapeutic efficacy of tofacitinib in PDSAg-induced chronic experimental autoimmune uveitis in Wistar rat	7
Ascorbic acid and hydrocortisone synergistically inhibit septic organ injury via improving oxidative stress and inhibiting inflammation	7
Amygdalin alleviates atopic dermatitis-like skin inflammation via inhibition of Th2 immune responses	7
Febuxostat attenuates cyclophosphamide-induced ovarian toxicity; role of TLR4/NFκB/NLRP3 signaling pathway in female wistar albino rats	7
Efficacy and safety of the combined use of ipilimumab and nivolumab for melanoma patients with brain metastases: a systematic review and meta-analysis	7
All- trans retinoic acid ameliorates S100-induced experimental autoimmune hepatitis by regulating the Treg/Th17 balance	7
Vildagliptin attenuates doxorubicin-induced hepatotoxicity via activating Nrf2/HO-1 and SIRT1 and suppressing NF-κB signals in rats	7
Acute kidney injury associated with anti-PD-1 and anti-PD-L1 drugs: a meta-analysis of randomized clinical trials	7
Nanocarriers for lung health: ameliorating inflammation and cell aging using flavonoid-based nano nutrients	7
Icariin decreases cell proliferation and inflammation of rheumatoid arthritis-fibroblast like synoviocytes via GAREM1/MAPK signaling pathway	7
Hydroxychloroquine exacerbates imiquimod-induced psoriasis-like dermatitis through stimulating overexpression of IL-6 in keratinocytes	7
microRNA-103a-3p promotes inflammation and fibrosis in nonalcoholic fatty liver disease by targeting HBP1	6
The dual potential of topical roflumilast: advancing psoriasis therapy and pioneering oral mucosal disease treatment	6
Immunomodulatory effect of vitamin D supplementation on Behçet’s disease patients: effect on nitric oxide and Th17/Treg cytokines production	6
Evaluation of HER-2 positive breast cancer treated with dual-targeted treatment of trastuzumab plus pertuzumab	6
Tumor cells inhibit the activation of ILC2s through up-regulating PD-1 expression	6
Fumaric acid per se and in combination with methotrexate arrests inflammation via moderating inflammatory and oxidative stress biomarkers in arthritic rats	6
Investigation of the therapeutic potential of recombinant bispecific bivalent anti-PD-L1/VEGF nanobody in inhibition of angiogenesis	6
Sulforaphane suppresses skin squamous cell carcinoma cells proliferation through miR-199a-5p/Sirt1/CD44ICD signaling pathway	6
Compound glycyrrhiza oral solution alleviates oxidative stress and inflammation by regulating SRC/MAPK pathway in chronic obstructive pulmonary disease	6
The transcriptomic profile shows the protective effects of celecoxib on cirrhotic splenomegaly	6
Mavorixafor: a CXCR4 antagonist for WHIM syndrome	6
Studying the effect of chronic toxicity of monosodium glutamate on interleukin-10 and interleukin-17 in albino Wistar rats	6
Breviscapine inhibits the proliferation and immune escape of diffuse large B-cell lymphoma cells by regulating JAK2/STAT3/PD-L1 pathway	6
Sodium benzoate exacerbates hepatic oxidative stress and inflammation in lipopolysaccharide-induced liver injury in rats	6
α-Cyperone ameliorates depression in mammary gland hyperplasia and chronic unpredictable mild stress rat by regulating hormone, inflammation, and oxidative stress	6
Multi-omics profiling uncovers candidate genes for the treatment of graves’ disease	6
Unexplained lymphadenopathy following adjuvant immunotherapy in a non-small cell lung cancer patient: a literature review and a rare case report	6
The therapeutic potential of jaceosidin: a comprehensive review of its effects on chronic diseases	6
Vinpocetine mitigates methotrexate-induced duodenal intoxication by modulating NF-κB, JAK1/STAT-3, and RIPK1/RIPK3/MLKL signals	6
The effect of vitamin C supplementation on favipiravir-induced oxidative stress and proinflammatory damage in livers and kidneys of rats	6
Reno-protective impact of diosmin and perindopril in amikacin-induced nephrotoxicity rat model: modulation of SIRT1/p53/C-FOS, NF-κB-p65, and keap-1/Nrf2/HO-1 signaling pathways	6
Isorhamnetin ameliorates cisplatin-induced acute kidney injury in mice by activating SLPI-mediated anti-inflammatory effect in macrophage	5
Sodium hyaluronate and pranoprofen improve visual function and reduce inflammation in patients with dry eye	5
Intravenous As 2 O 3 as a promising treatment for psoriasis — an experimental study in psoriasis-l	5
Potential regulation of artesunate on bone metabolism through suppressing inflammatory infiltration in type 2 diabetes mellitus	5
miR-155-5p/FOXO3a promotes pulmonary fibrosis in rats by mediating NLRP3 inflammasome activation	5
Matrine alleviates the immune imbalance of atopic dermatitis by up-regulating FOXO4 to inactivate circTNFRSF21-mediated JAK/STAT3 axis	5
Clinical characteristics, treatment, and outcomes of nivolumab-induced uveitis	5
Thiolutin, a selective NLRP3 inflammasome inhibitor, attenuates cyclophosphamide–induced impairment of sperm and fertility in mice	5
The role of PI3K/AKT-related proteins in di(2-ethyl)hexylphthalate-induced BG-1 and MCF-7 cell proliferation, and inhibition by metformin	5
The effect of omega-3 fatty acids supplementation on inflammatory biomarkers in subjects with migraine: a randomized, double-blind, placebo-controlled trial	5
Randomized double-blinded controlled trial on the effect of synbiotic supplementation on IL-17/IL-23 pathway and disease activity in patients with axial spondyloarthritis	5
Tetrandrine-induced downregulation of lncRNA NEAT1 inhibits rheumatoid arthritis progression through the STAT3/miR-17-5p pathway	5
Tectoridin alleviates lipopolysaccharide-induced inflammation via inhibiting TLR4-NF-κB/NLRP3 signaling in vivo and in vitro	5
A comparison of panitumumab and cetuximab in the treatment of KRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis	5
Sotrovimab therapy in solid organ transplant recipients with mild to moderate COVID-19: a systematic review and meta-analysis	5
To evaluate the short and long term outcomes of renal transplant recipients with low dose everolimus, tacrolimus-based minimal quadruple immunosuppressive regimen	5
Isoliquiritin modulates ferroptosis via NF-κB signaling inhibition and alleviates doxorubicin resistance in breast cancer	5
Immuno-metabolic reprogramming of T cell: a new frontier for pharmacotherapy of Rheumatoid arthritis	5
Cannabidiol and low-dose γ-radiation regulate alterations consequences of hepatic-encephalopathy induced by thioacetamide: neuroprotective and anti-inflammatory role	4
Galantamine and wedelolactone combined treatment suppresses LPS-induced NLRP3 inflammasome activation in microglial cells	4
Avarol protects HT22 neuronal cells from BV2 microglia cell-derived neuroinflammation in lipopolysaccharide-induction model	4
Absence of active systemic anaphylaxis in guinea pigs upon intramuscular injection of inactivated SARS-CoV-2 vaccine (Vero cells)	4
A case report of carboxymethylcellulose allergy: exploring tolerance based on administration route	4
Ginseng polysaccharide promotes the apoptosis of colon cancer cells via activating the NLRP3 inflammasome	4
Protective efficacy of melatonin and insulin against LPS caused toxicity in diabetic mice	4
Immunomodulatory roles of propofol and sevoflurane in murine models of breast cancer	4
N-acetylcysteine decreases lung inflammation and fibrosis by modulating ROS and Nrf2 in mice model exposed to particulate matter	4
Pre-clinical investigation of protective effect of nutraceutical D-glucosamine on TNBS-induced colitis	4
Farnesol mitigates methotrexate-induced intestinal toxicity by enhancing SIRT1, PPAR-γ, and Nrf2 signaling and attenuating Bax/cytochrome c /caspase-3–me	4
Diethylcarbamazine reduces the viral titer of influenza A (H1N1)pdm09 virus and regulates IFN-β and IL-8 in infected epithelial cells	4
Sufentanil inhibits the metastasis and immune response of breast cancer via mediating the NF-κB pathway	4
Efficacy and safety of Nivolumab in patients with advanced esophageal, gastroesophageal, and gastric cancers: a meta-analysis of randomized controlled trials	4
Intervention of inflammation associated with ankylosing spondylitis by triptolide promotes histone H3 Iys-27 trimethylation	4
Morphine upregulates Toll-like receptor 4 expression and promotes melanomas in mice	4
Implications of glucocorticoid-induced co-inhibitory molecule expression on combined glucocorticoid and immune checkpoint inhibitor therapy	4
Exploring the role of ATP-sensitive potassium channel, eNOS, and P-glycoprotein in mediating the hepatoprotective activity of nicorandil in methotrexate-induced liver injury in rats	4
Immune checkpoint inhibitors and immunosuppressive tumor microenvironment: current challenges and strategies to overcome resistance	4
Dichapetalin-type triterpenoids inhibits macrophage interferon expression by regulating the cGas-STING pathway, suggesting potential application in immunosuppression	4
Is resveratrol really effective in kidney disease?: A different perspective than ever before	3
Triptolide attenuates LPS-induced activation of RAW 264.7 macrophages by inducing M1-to-M2 repolarization via the mTOR/STAT3 signaling	3
Circular RNA from phosphodiesterase 4D can attenuate chondrocyte apoptosis and matrix degradation under OA milieu induced by IL-1β via circPDE4D/miR-4306/SOX9 Cascade	3
The effects of amiodarone in ovarian injury due to oxidative stress and inflammation caused by ischemia-reperfusion	3
Knockdown of A20 attenuates microglial susceptibility to OGD/R-induced ferroptosis and upregulates inflammatory responses	3
Anlotinib attenuates experimental autoimmune encephalomyelitis mice model of multiple sclerosis via modulating the differentiation of Th17 and Treg cells	3
Anti-inflammatory activity of 2-methoxy-4-vinylphenol involves inhibition of lipopolysaccharide-induced inducible nitric oxidase synthase by heme oxygenase-1	3

Trastuzumab biosimilars vs trastuzumab originator in the treatment of HER2-positive breast cancer: a systematic review and network meta-analysis	3
The AMPK-SIRT1-FoxO1-NF-κB signaling pathway participates in hesperetin-mediated neuroprotective effects against traumatic brain injury via the NLRP3 inflammasome	3
Effect of dapagliflozin on sepsis-induced kidney injury in a rat model: modulation of the NLRP3 pathway	3
Secreted phosphoprotein 1 regulates natural compound 3’,4’,5,7-tetrahydroxyflavone to inhibit mast cell-mediated allergic inflammation	3
Immune checkpoints in hepatocellular carcinoma and the challenges of therapeutic resistance	3
Vinpocetine attenuates 5-fluorouracil-induced intestinal injury: role of the Keap1/Nrf2/HO-1, NF-κB/TLR4/SOCS3 and RIPK1/RIPK3/MLKL signals	3
Cardamonin inhibits the expression of inflammatory mediators in TNF-α-stimulated human periodontal ligament cells	3
Dexmedetomidine alleviates hyperalgesia in arthritis rats through inhibition of the p38MAPK signaling pathway	3
Correction	3
Implications of inflammasomes in dental pulp inflammation: immunopathology and therapeutic targeting	3
Human milk oligosaccharide disialyllacto-n-tetraose protects human intestinal epithelium integrity and permeability against mast cell chymase-induced disruption by stabilizing ZO-1/FAK/P38 pathway of	3
Possible anti-inflammatory, antioxidant, and neuroprotective effects of apigenin in the setting of mild traumatic brain injury: an investigation*	3
Medicarpin suppresses thyroid cancer progression by inhibiting the AKT/NF-κB pathway and enhancing CD8 + T cell-mediated antitumor immunity	3
Citicoline modulates inflammatory signaling pathways in the spleen of rats exposed to gamma-radiation	3
Sunitinib alleviates hepatic ischemia reperfusion injury by inhibiting the JAK2/STAT pathway and promoting the M2 polarization of macrophages	3
Human umbilical-cord-derived mesenchymal stem cells in combination with rapamycin reduce cartilage degradation via inhibition of the AKT/mTOR signaling pathway	3
Targeting the cGAS-STING pathway as an inflammatory crossroad in coronavirus disease 2019 (COVID-19)	3
Alpha-cyperone ameliorates renal fibrosis and inflammation in mice with chronic kidney disease via NF-κB and Akt/Nrf2/HO-1 pathways	3
Functional role of granulocytic myeloid-derived suppressor cells in CAR-T therapy: insights from single-cell RNA sequencing in multiple myeloma	3
Attenuation of adjuvant-induced arthritis with carnosic acid by inhibiting mPGES-1, COX-2, and bone loss in male SD rats	3