OOIR: Observatory of International Research

Papers

(The TQCC of Immunopharmacology and Immunotoxicology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Isoliquiritin modulates ferroptosis via NF-κB signaling inhibition and alleviates doxorubicin resistance in breast cancer	89
Immuno-metabolic reprogramming of T cell: a new frontier for pharmacotherapy of Rheumatoid arthritis	64
miR-155-5p/FOXO3a promotes pulmonary fibrosis in rats by mediating NLRP3 inflammasome activation	62
Leukoreduced PRP enhanced proliferation and ECM production yet inhibited senescence, inflammation, and multi-differentiation potential of AFSCs by downregulating HMGB1	40
Prospective therapeutic targets and recent advancements in the treatment of inflammatory bowel disease	35
Seasonal facial erythema in a patient with allergic rhinitis treated using a combination of tranilast and roxithromycin	35
Efficacy and safety of immune checkpoint inhibitors combined with anti-VEGF therapy in the treatment of unresectable or advanced liver cancer: a systematic review	30
CCL2 regulated by the CTBP1-AS2/miR-335-5p axis promotes hemangioma progression and angiogenesis	30
Randomized double-blinded controlled trial on the effect of synbiotic supplementation on IL-17/IL-23 pathway and disease activity in patients with axial spondyloarthritis	29
SESLA suppresses the activation of macrophages and dendritic cells after Gram-positive bacterial challenge	25
MiR-222-3p inhibits formation of medulloblastoma stem-like cells by targeting Notch2/c-myc signaling pathway	25
Gastrodin ameliorates Concanavalin A-induced acute hepatitis via the IL6/JAK2/STAT3 pathway	23
Decreasing REDD1 expression protects against high glucose-induced apoptosis, oxidative stress and inflammatory injury in podocytes through regulation of the AKT/GSK-3β/Nrf2 pathway	22
Tetrandrine-induced downregulation of lncRNA NEAT1 inhibits rheumatoid arthritis progression through the STAT3/miR-17-5p pathway	21
Luteolin restored Treg/Th17 balance to ameliorate allergic rhinitis in a mouse model	20
Pre-clinical investigation of protective effect of nutraceutical D-glucosamine on TNBS-induced colitis	19
The effect of omega-3 fatty acids supplementation on inflammatory biomarkers in subjects with migraine: a randomized, double-blind, placebo-controlled trial	19
Inhibition of O-glycosylation aggravates GalN/LPS-induced liver injury through activation of ER stress	18
The protective effects of a single dose myricetin application on CLP-induced rat sepsis model by analyzing some immune mechanisms	17
Extracellular vesicle-derived LINC00511 promotes glycolysis and mitochondrial oxidative phosphorylation of pancreatic cancer through macrophage polarization by microRNA-193a-3p-dependent regulation of	17
MG53 represses high glucose-induced inflammation and angiogenesis in human retinal endothelial cells by repressing the EGR1/STAT3 axis	16
Monensin synergizes with chemotherapy in uveal melanoma through suppressing RhoA	16
Eupatilin inhibits keratinocyte proliferation and ameliorates imiquimod-induced psoriasis-like skin lesions in mice via the p38 MAPK/NF-κB signaling pathway	16
Catechin regulates miR-182/GGPPS1 signaling pathway and inhibits LPS-induced acute lung injury in mice	15
Corynoline ameliorates dextran sulfate sodium-induced colitis in mice by modulating Nrf2/NF-κB pathway	15

Anti-tumor effect of M2000 (β- d -mannuronic acid) on the expression of inflammatory molecules in the prostate cancer cell	15
Interferon-α2b induced anemia in severe coronavirus disease 2019 patients: a single centered, retrospective study	15
Amnion membrane proteins attenuate LPS-induced inflammation and apoptosis by inhibiting TLR4/NF-κB pathway and repressing MicroRNA-155 in rat H9c2 cells	15
Efficacy assessment of a triple anthrax chimeric antigen as a vaccine candidate in guinea pigs: challenge test with Bacillus anthracis 17 JB strain spores	14
Protective effects of Tripterygium glycoside on IL-1β-induced inflammation and apoptosis of rat chondrocytes via microRNA-216a-5p/TLR4/NF-κB axis	14
Anti-psoriasis activities of hydroxytyrosol on HaCaT cells under psoriatic inflammation in vitro	14
HIV protease inhibitor saquinavir inhibits toll-like receptor 4 activation by targeting receptor dimerization	13
Effects of Trigonella foenum graecum (fenugreek) on rheumatoid arthritis: a systematic review	13
Leptin/lipopolysaccharide-treated dendritic cell vaccine improved cellular immune responses in an animal model of breast cancer	13
The role of PI3K/AKT-related proteins in di(2-ethyl)hexylphthalate-induced BG-1 and MCF-7 cell proliferation, and inhibition by metformin	13
Cycloastragenol restrains keratinocyte hyperproliferation by promoting autophagy via the miR-145/STC1/Notch1 axis in psoriasis	13
An integrative lipidomics and transcriptomics study revealing Bavachin and Icariin synergistically induce idiosyncratic liver injury	12
Occupational exposure to pesticides affects systemic cytokine profile and correlates with poor clinical prognosis in young women with breast cancer	12
Study on the mechanism of glucocorticoid receptor mitochondrial translocation and glucocorticoid-induced apoptosis in macrophages	12
Cynarin ameliorates dextran sulfate sodium-induced acute colitis in mice through the STAT3/NF-κB pathway	12
Sirtinol, a SIRT1 inhibitor, inhibits the EMT and metastasis of 4T1 breast cancer cells and impacts the tumor microenvironment	12
Galectin-1-producing mesenchymal stem cells restrain the proliferation of T lymphocytes from patients with systemic lupus erythematosus	12
Efficacy and safety of combining radiotherapy with immune checkpoint inhibitors in patients with advanced non-small cell lung cancer: a real-world study	12
1,25(OH) ₂ D ₃ -treated mouse bone marrow-derived dendritic cells alleviate autoimmune hepatitis in mice by improving TFR/TFH imba	11
Crocin as a potential therapeutic agent for multiple sclerosis: insights from experimental autoimmune encephalomyelitis model in mice	11
Matairesinol repolarizes M2 macrophages to M1 phenotype to induce apoptosis in triple-negative breast cancer cells	11
CIITA expression is regulated by histone deacetylase enzymes and has a role in α-synuclein pre-formed fibril-induced antigen presentation in murine microglial cell line	11
BACE1 inhibition via miR-6838-5p overexpression inhibits insulin resistance and the immune response in HFD-induced obesity in mice model	11
Prognostic values of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in the early prediction of aluminum phosphide-poisoned patients’ outcomes	11
Asiatic acid exerts an anti-psoriatic effect in the imiquimod-induced psoriasis model in mice	11
Presence of anti-TIF-1γ, anti-Ro52, anti-SSA/Ro60 and anti-Su/Ago2 antibodies in breast cancer: a cross-sectional study	10
LY294002 attenuates inflammatory response in endotoxin-induced uveitis by downregulating JAK3 and inactivating the PI3K/Akt signaling	10
Purinergic receptor ligands: the cytokine storm attenuators, potential therapeutic agents for the treatment of COVID-19	10
Reno-protective effect of fenofibrate and febuxostat against vancomycin-induced acute renal injury in rats: Targeting PPARγ/NF-κB/COX-II and AMPK/Nrf2/HO-1 signaling pathways	10
Mechanism of neuroprotective effect of stevioside on cerebral ischemia-reperfusion injury via PPAR-γ activation	10
Potential regulation of artesunate on bone metabolism through suppressing inflammatory infiltration in type 2 diabetes mellitus	9
Zerumbone modulates the expression of inflammatory mediators and antioxidant enzymes in TNF-α-stimulated human periodontal ligament cells	9
Imperatorin inhibits LPS-induced bone marrow-derived macrophages activation by decreased NF-κB p65 phosphorylation	9
Protective effect of modafinil in bisphenol A-induced lung injury in rats: roles of SIRT1-dependent signaling pathways	9
Circ_0025033 deficiency suppresses paclitaxel resistance and malignant development of paclitaxel-resistant ovarian cancer cells by modulating the miR-532-3p/FOXM1 network	9
Dexpanthenol may protect the brain against lipopolysaccharide induced neuroinflammation via anti-oxidant action and regulating CREB/BDNF signaling	9
Immunoglobulin a suppresses B cell receptor-mediated activation of mouse B cells with differential inhibition of signaling molecules	8
Neutrophil Extracellular Traps (NET) and SARS-CoV-2	8
Immunomodulatory effects of fentanyl and morphine on DSS- and TNBS-induced colitis	8
Picroside II alleviates DSS-induced ulcerative colitis by suppressing the production of NLRP3 inflammasomes through NF-κB signaling pathway	8
Combination therapies and other therapeutic approaches targeting the NLRP3 inflammasome and neuroinflammatory pathways: a promising approach for traumatic brain injury	8
Silencing lncRNA LINC01410 suppresses cell viability yet promotes apoptosis and sensitivity to temozolomide in glioblastoma cells by inactivating PTEN/AKT pathway via targeting miR-370-3p	8
SRPK1 promotes sepsis-induced acute lung injury via regulating PI3K/AKT/FOXO3 signaling	8
The use of neutralizing monoclonal antibodies and risk of hospital admission and mortality in patients with COVID-19: a systematic review and meta-analysis of randomized trials	8
Wogonoside attenuates the articular cartilage injury and the infiltration of Th1/Th2-type cytokines in papain-induced osteoarthritis in rat model via inhibiting the NF-κB and ERK1/2 activation	8
Expression of calcitonin gene-related peptide in atopic dermatitis and correlation with distress	8
The function and mechanism of microRNA-92a-3p in lipopolysaccharide-induced acute lung injury	8
A calcium channel blocker, manoalide exerts an anti-allergic inflammatory effect through attenuating NF-κB activity	8
TIMP1 represses sorafenib-triggered ferroptosis in colorectal cancer cells by activating the PI3K/Akt signaling pathway	8
Artificial liver support systems bridge severe immune-mediated hepatotoxicity to clinical recovery	8

Anti-inflammatory effects of paeoniflorin caused by regulation of the hif1a/miR-210/caspase1/GSDMD signaling pathway in astrocytes: a novel strategy for hypoxia-induced brain injury in rats	8
Protective effect of pregabalin on renal and renal endothelial damage in sepsis induced by lipopolysaccharide	7
LINC00313 alleviates osteoarthritis progression in mice through promoting TRAF1 promoter methylation and inhibiting the ASK1/JNK signaling pathway	7
VISTA-Ig ameliorates OXA-induced allergic dermatitis symptoms in mice	7
Immunomodulatory effects ofInonotus obliquuspolysaccharide on splenic lymphocytes infected withToxoplasma gondiivia NF-κB and MAPKs pathways	7
What are the immunopharmacological effects of furazolidone? A systematic review	7
Xanthones from securidaca inappendiculata antagonizes the anti-rheumatic effect of methotrexate by inhibiting reduced folate carrier 1	7
Indole derivative XCR-5a alleviates LPS-induced inflammation in vitro and in vivo	7
Monotropein alleviates acute pulmonary embolism in rats by inhibiting the NF-κB pathway	7
The function and mechanism of dopamine in the activation of CD4⁺T cell	7
Absence of active systemic anaphylaxis in guinea pigs upon intramuscular injection of inactivated SARS-CoV-2 vaccine (Vero cells)	7
CD26 CAR-T cells have attenuated mitochondrial and glycolytic metabolic profiling	7
Morphine upregulates Toll-like receptor 4 expression and promotes melanomas in mice	6
PF127/bleomycin hydrogel promotes subcutaneous extracellular matrix remodeling and fibrosis to construct personalized flaps through the TGFβ-Col signaling pathway	6
Astilbin improves pregnancy outcome in rats with recurrent spontaneous abortion by regulating Th1/Th2 balance	6
Exploring the role of ATP-sensitive potassium channel, eNOS, and P-glycoprotein in mediating the hepatoprotective activity of nicorandil in methotrexate-induced liver injury in rats	6
Echinacoside alleviates osteoarthritis in rats by activating the Nrf2-HO-1 signaling pathway	6
Aloin alleviates corneal injury in alkali burn via inhibiting neutrophil extracellular traps and promoting Nrf2	6
Clinical features, treatment, and outcome of nivolumab-induced cholangitis	6
Neuroprotection of isoorientin against microglia activation induced by lipopolysaccharide via regulating GSK3β, NF-κb and Nrf2/HO-1 pathways	6
Safety observation of COVID-19 inactivated vaccine in immature mice	6
The effects of guluronic acid (G2013), a new emerging treatment, on inflammatory factors in nonalcoholic steatohepatitis patients under in vitro conditions	6
IL-27 overexpression alleviates inflammatory response in allergic asthma by inhibiting Th9 differentiation and regulating Th1/Th2 balance	6
The protective effect of teprenone in TNBS-induced ulcerative colitis rats by modulating the gut microbiota and reducing inflammatory response	6
Mannose targeting of poly(lactic-co-glycolic acid): a promising approach for improving sublingual allergen-specific immunotherapy	6
Wogonoside preserves against ischemia/reperfusion-induced myocardial injury by suppression of apoptosis, inflammation, and fibrosis via modulating Nrf2/HO-1 pathway	6