OOIR: Observatory of International Research

Papers

(The H4-Index of Chemical Research in Toxicology is 28. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Elevating Research and Careers in the Development of Safer Drugs through Artificial Intelligence	89
Oxidative Deformylation of the Predominant DNA Lesion 5-Formyl-2′-deoxyuridine	85
Capture of Electrophilic Quinones in the Extracellular Space: Evidence for a Phase Zero Reaction	73
Recent Advances in DNA Lesion Mapping and Repair Mechanisms	69
Electrochemical Simulation of the Oxidative Capsaicin Metabolism	66
Predicting Liver-Related In Vitro Endpoints with Machine Learning to Support Early Detection of Drug-Induced Liver Injury	56
Coumarin-Based Noncytotoxicity Fluorescent Dye for Tracking Actin Protein in In-Vivo Imaging	53
Surfactant Coformulants in Glyphosate-Based Herbicides: Current Gaps, and Paths Forward in Human Biomonitoring	52
Dissecting the Enantioselective Neurotoxicity of Isocarbophos: Chiral Insight from Cellular, Molecular, and Computational Investigations	50
LA-ICP-MS and Immunohistochemical Staining with Lanthanide-Labeled Antibodies to Study the Uptake of CeO₂ Nanoparticles by Macrophages in Tissue Sections	49
A Weakly Supervised Deep Learning Framework for Whole Slide Classification to Facilitate Digital Pathology in Animal Study	47
Advances in Metabolism and Metabolic Toxicology of Quinoxaline 1,4-Di-N-oxides	47
Identification of an Epoxide Metabolite of Amitriptyline In Vitro and In Vivo	42
Systematic Investigation of CYP3A4 Using Side-by-Side Comparisons of Apo, Active Site, and Allosteric-Bound States	41
Issue Publication Information	40
Issue Publication Information	40
Issue Editorial Masthead	39
Issue Editorial Masthead	37
Protein Haptenation and Its Role in Allergy	35
Mechanistic Insights into Toxicity of Titanium Dioxide Nanoparticles at the Micro- and Macro-levels	34
In Vitro and In Vivo Analysis of Fentanyl and Fentalog Metabolites using Hyphenated Chromatographic Techniques: A Review	33
Bioaccumulation and DNA Adduct Formation of Aristolactam I: Unmasking a Toxicological Mechanism in the Pathophysiology of Aristolochic Acid Nephropathy	33
A Review on the Recent Applications of Deep Learning in Predictive Drug Toxicological Studies	32
Application of Covalent Binding Body Burden in the HμREL Human Hepatocyte Coculture Model for Reactivity Risk Assessment of Metabolically Low Turnover Drugs	31
Cellular Interactions and Fatty Acid Transporter CD36-Mediated Uptake of Per- and Polyfluorinated Alkyl Substances (PFAS)	31

Alternaria alternata Mycotoxins Activate the Aryl Hydrocarbon Receptor and Nrf2-ARE Pathway to Alter the Structure and Immune Response of Colon Epithelial Cells	30
Nonclinical Safety Signals in PharmaPendium Improve the Predictability of Human Drug-Induced Liver Injury	29
Mass Spectrometry-Based Metabolic Profiling of Urinary Metabolites of N′-Nitrosonornicotine (NNN) in the Rat	29
The Toxicity of Poly(acrylonitrile-styrene–butadiene) Microplastics toward Hyalella azteca Is Associated with Biofragmentation and Oxidative Stress	28
Leveraging Cell Painting Images to Expand the Applicability Domain and Actively Improve Deep Learning Quantitative Structure–Activity Relationship Models	28
Potential Involvement of Sulfotransferase in the Mechanism of Lamotrigine-induced Skin Rash	28