OOIR: Observatory of International Research

Papers

(The median citation count of Chemical Research in Toxicology is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Issue Publication Information	88
Issue Editorial Masthead	77
Issue Publication Information	73
Novel Δ⁸-Tetrahydrocannabinol Vaporizers Contain Unlabeled Adulterants, Unintended Byproducts of Chemical Synthesis, and Heavy Metals	60
Issue Editorial Masthead	60
Predicting Liver-Related In Vitro Endpoints with Machine Learning to Support Early Detection of Drug-Induced Liver Injury	60
In Vitro Glucuronidation of Caribbean Ciguatoxins in Fish: First Report of Conjugative Ciguatoxin Metabolites	60
Issue Publication Information	58
Issue Publication Information	51
Systematic Approaches for the Encoding of Chemical Groups: A Case Study	50
Application of Covalent Binding Body Burden in the HμREL Human Hepatocyte Coculture Model for Reactivity Risk Assessment of Metabolically Low Turnover Drugs	44
Special Issue on Tobacco: Chemistry, Mechanisms, Biomarkers and Disease Prevention	43
Issue Editorial Masthead	43
Metals Come in Many Flavors–Is Inference about the Health Effects of Tattoo Inks Based on the Analysis of Inorganic Elements Justified?	40
Prediction and Structure–Activity Relationship Analysis on Ready Biodegradability of Chemical Using Machine Learning Method	40
Letter to the Editor Regarding Benzophenone Accumulates over Time from the Degradation of Octocrylene in Commercial Sunscreen Products	40
Issue Publication Information	40
In Vitro and In Vivo Analysis of Fentanyl and Fentalog Metabolites using Hyphenated Chromatographic Techniques: A Review	38
Issue Publication Information	35
Assessment of the Intestinal Absorption of Higher Olefins by the Everted Gut Sac Model in Combination with In Silico New Approach Methodologies	33
Correction to DNA Polymerase II Supports the Replicative Bypass of N²-Alkyl-2′-deoxyguanosine Lesions in Escherichia coli Cells	33
Reply to the Comment on Critical Choices in Predicting Stone Wool Biodurability: Lysosomal Fluid Compositions and Binder Effects	31
Issue Publication Information	31
Comparative Effects of Brominated Flame Retardants BDE-209, TBBPA, and HBCD on Neurotoxicity in Mice	30
Issue Editorial Masthead	30

Structure–Activity Relationship of Lower Chlorinated Biphenyls and Their Human-Relevant Metabolites for Astrocyte Toxicity	30
Issue Publication Information	29
Issue Editorial Masthead	28
A New Explanation for the Mystery of Rasputin’s Survival of Cyanide Poisoning: Eating Raw Garlic	28
Issue Editorial Masthead	28
Issue Editorial Masthead	27
Theoretical Validation of In Chemico Skin Sensitization Assay “ADRA” Using the Products Formed by Nucleophilic Reagents and Chemicals	26
Issue Publication Information	25
Use of Solvent Mapping for Characterizing the Binding Site and for Predicting the Inhibition of the Human Ether-á-Go-Go-Related K⁺ Channel	25
Issue Publication Information	25
Transcription Factor ELF1 Modulates Cisplatin Sensitivity in Prostate Cancer by Targeting MEIS Homeobox 2	24
A Wide Range of Flavoring–Carrier Fluid Adducts Form in E-Cigarette Liquids	24
Correction to “Berberine Inhibits KLF4 Promoter Methylation and Ferroptosis to Ameliorate Diabetic Nephropathy in Mice”	23
Inhibitory Effects of Alkaloids on OATP1B1 In Vitro and In Vivo: Prediction for Food/Herb–Drug Interactions and Hepatoprotective Effects Based on Structure–Activity Relationships	23
Metabolic Activation of Stiripentol Correlates with Cytotoxicity	22
PFOS-Induced Perturbations in Trophoblast Functions through the Oip5os1/miR-155/Rnd3 Axis in PE	22
Protein Haptenation and Its Role in Allergy	22
Perfluorobutanesulfonate Induces Hypothalamic–Pituitary–Gonadal Axis Disruption and Gonadal Dysplasia of Lithobates catesbeianus Tadpoles	21
Correction to “Oxymatrine Inhibits Liver Cancer Progression by Regulating SIRT1/YY1/GPX4 Axis-Mediated Ferroptosis”	21
Nonclinical Evaluation of Antibacterial Oxazolidinones Contezolid and Contezolid Acefosamil with Low Serotonergic Neurotoxicity	20
Multi-DNA Adduct and Abasic Site Quantitation In Vivo by Nano-Liquid Chromatography/High-Resolution Orbitrap Tandem Mass Spectrometry: Methodology for Biomonitoring Colorectal DNA Damage	20
The Amyloid Aggregation Accelerator Diacetyl Prevents Cognitive Decline in Alzheimer’s Mouse Models	20
Response to the Letter to the Editor by Dr. Christian Surber	20
Elevating Research and Careers in the Development of Safer Drugs through Artificial Intelligence	20
Probing the Hidden Role of Mitochondrial DNA Damage and Dysfunction in the Etiology of Aristolochic Acid Nephropathy	20
Ultrafast Reaction of the Drug Hydralazine with Apurinic/Apyrimidinic Sites in DNA Gives Rise to a Stable Triazolo[3,4-a]phthalazine Adduct	20
Alternaria alternata Mycotoxins Activate the Aryl Hydrocarbon Receptor and Nrf2-ARE Pathway to Alter the Structure and Immune Response of Colon Epithelial Cells	19
Identification of an Epoxide Metabolite of Amitriptyline In Vitro and In Vivo	19
Systematic Investigation of CYP3A4 Using Side-by-Side Comparisons of Apo, Active Site, and Allosteric-Bound States	19
Electrochemical Simulation of the Oxidative Capsaicin Metabolism	19
Antioxidant Activity and Skin Sensitization of Eugenol and Isoeugenol: Two Sides of the Same Coin?	19
Cyanide Trapping of Iminium Ion Reactive Metabolites: Implications for Clinical Hepatotoxicity	19
Role of Particulate Matter from Afghanistan and Iraq in Deployment-Related Lung Disease	18
Impact of Metal–Organic Frameworks on Protein Expression	18
Advances in Smoking Related In Vitro Inhalation Toxicology: A Perspective Case of Challenges and Opportunities from Progresses in Lung-on-Chip Technologies	18
Novel 4-Hydroxybenzyl Adducts in Human Hemoglobin: Structures and Mechanisms of Formation	18
New Synthetic Analogs of Nitrogen Mustard DNA Interstrand Cross-Links and Their Use to Study Lesion Bypass by DNA Polymerases	18
Genetically Encoded Fluorescent Redox Indicators for Unveiling Redox Signaling and Oxidative Toxicity	18
Amino Reactivity of Glutardialdehyde and Monoaldehydes─Chemoassay Profile vs Skin Sensitization Potency	17
LA-ICP-MS and Immunohistochemical Staining with Lanthanide-Labeled Antibodies to Study the Uptake of CeO₂ Nanoparticles by Macrophages in Tissue Sections	17
The Dawn of a New Era in Drug Discovery? Drug Screening and the Increasing Biological Complexity of Testing Models	17
In Vitro and In Vivo Metabolic Activation and Hepatotoxicity of Environmental Pollutant 2,6-Dimethylphenol	17
Chronic Exposure to Climbazole Induces Oxidative Stress and Sex Hormone Imbalance in the Testes of Male Zebrafish	17
miR133b Microinjection during Early Development Targets Transcripts of Cardiomyocyte Ion Channels and Induces Oil-like Cardiotoxicity in Zebrafish (Danio rerio) Embryos	17
Increased Levels of the Acrolein Metabolite 3-Hydroxypropyl Mercapturic Acid in the Urine of e-Cigarette Users	16
Pancreatic INS-1 β-Cell Response to Thapsigargin and Rotenone: A Comparative Proteomics Analysis Uncovers Key Pathways of β-Cell Dysfunction	16
MicroRNA Expression Influences Methylmercury-Induced Lipid Accumulation and Mitochondrial Toxicity in Caenorhabditis elegans	16
Redox Homeostasis is Disturbed by Redox Cycling between Reactive Cysteines of Thioredoxin 1 and 9,10-Phenanthrenequinone, an Atmospheric Electron Acceptor	16
Cannabis Vaping: Existing and Emerging Modalities, Chemistry, and Pulmonary Toxicology	16
Mass Spectrometric Quantitation of N′-Nitrosonornicotine-1N-oxide in the Urine of Cigarette Smokers and Smokeless Tobacco Users	16

Development of a Liquid Chromatography–Mass Spectrometry-Based In Vitro Assay to Assess Changes in Steroid Hormones Due to Exposure to Per- and Polyfluoroalkyl Substances	16
Pathogenic and Commensal Gut Bacteria Harboring Glycerol/Diol Dehydratase Metabolize Glycerol and Produce DNA-Reactive Acrolein	16
Identification of Formaldehyde-Induced DNA–RNA Cross-Links in the A/J Mouse Lung Tumorigenesis Model	15
Dissecting the Enantioselective Neurotoxicity of Isocarbophos: Chiral Insight from Cellular, Molecular, and Computational Investigations	15
Zebrafish Oatp1d1 Acts as a Cellular Efflux Transporter of the Anionic Herbicide Bromoxynil	15
Recent Advances in DNA Lesion Mapping and Repair Mechanisms	15
An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Conce	15
Capture of Electrophilic Quinones in the Extracellular Space: Evidence for a Phase Zero Reaction	15
Insulin Signaling Disruption and INF-γ Upregulation Induce Aβ_1–42 and Hyperphosphorylated-Tau Proteins Synthesis and Cell Death after Paraquat Treatment of Primary Hippocampal Cells	15
Bioaccumulation and DNA Adduct Formation of Aristolactam I: Unmasking a Toxicological Mechanism in the Pathophysiology of Aristolochic Acid Nephropathy	14
Cellular Interactions and Fatty Acid Transporter CD36-Mediated Uptake of Per- and Polyfluorinated Alkyl Substances (PFAS)	14
Machine Learning Model for Screening Thyroid Stimulating Hormone Receptor Agonists Based on Updated Datasets and Improved Applicability Domain Metrics	14
Toxicoproteomics of Mono(2-ethylhexyl) phthalate and Perfluorooctanesulfonic Acid in Models of Prostatic Diseases	14
Novel Processes Associated with the Repair of Interstrand Cross-Links Derived from Abasic Sites in Duplex DNA: Roles for the Base Excision Repair Glycosylase NEIL3 and the SRAP Protein HMCES	14
Computational Approach to Link Chemicals in Anthropogenic Smoke Particulate Matter with Toxicity	14
Mitigating a Bioactivation Liability with an Azetidine-Based Inhibitor of Diacylglycerol Acyltransferase 2 (DGAT2) En Route to the Discovery of the Clinical Candidate Ervogastat	14
New Insights into the Phototoxicity of Anthracene-Based Chromophores: The Chloride Salt Effect	14
Human CYP2C19 Substrate and Inhibitor Characterization of Organophosphate Pesticides	14
Mass Spectrometric Analysis of the Active Site Tryptic Peptide of Recombinant O⁶-Methylguanine-DNA Methyltransferase Following Incubation with Human Colorectal DNA Reveals the Presen	14
Cystine/Glutamate Xc^– Antiporter Induction Compensates for Transsulfuration Pathway Repression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Ensure Cysteine for Hepatic Glutathion	14
Effects of E-Cigarette Flavor Enhancing Capsules on Inhalable Aerosols	14
Correction to “Structural and Mechanistic Investigation of the Unusual Metabolism of Nifurtimox”	14
Multiplatform Metabolomics to Understand the Imidacloprid-Induced Toxicity in Drosophila	14
Detrimental Role of CXCR3 in α-Naphthylisothiocyanate- and Triptolide-Induced Cholestatic Liver Injury	14
Identification of Tellurium Metabolite in Broccoli Using Complementary Analyses of Inorganic and Organic Mass Spectrometry	13
Advances in Metabolism and Metabolic Toxicology of Quinoxaline 1,4-Di-N-oxides	13
Exploring the Cellular Impact of Size-Segregated Cigarette Aerosols: Insights into Indoor Particulate Matter Toxicity and Potential Therapeutic Interventions	13
Oxidative Deformylation of the Predominant DNA Lesion 5-Formyl-2′-deoxyuridine	13
Environmental Stability Determines the Cytotoxicity of Metal–Organic Frameworks to a Nitrogen-Fixing Bacterium Azotobacter vinelandii	13
Novel Dual PPAR δ/γ Partial Agonist Induces Hepatic Lipid Accumulation through Direct Binding and Inhibition of AKT1 Phosphorylation, Mediating CD36 Upregulation	13
Heterogeneity of Harmful Constituent Profiles in Smokeless Tobacco Products from Five African Countries	13
Burn Pit Smoke Condensate-Mediated Toxicity in Human Airway Epithelial Cells	13
Coumarin-Based Noncytotoxicity Fluorescent Dye for Tracking Actin Protein in In-Vivo Imaging	13
In Vitro Screening for ToxCast Chemicals Binding to Thyroxine-Binding Globulin	13
O⁶-Alkylguanine-DNA Alkyltransferase Maintains Genome Integrity by Forming DNA–Protein Cross-Links during Inflammation-Associated Peroxynitrite-Mediated DNA Damage	13
Cel-CS1K: A Celastrol–Chitosan Conjugate for Treating Diet-Induced Obesity	13
Tissue Organoid Cultures Metabolize Dietary Carcinogens Proficiently and Are Effective Models for DNA Adduct Formation	13
Urinary Excretion of Mercapturic Acids of the Rodent Carcinogen Methyleugenol after a Single Meal of Basil Pesto: A Controlled Exposure Study in Humans	13
Machine Learning Enables Accurate Prediction of Quinone Formation during Drug Metabolism	13
Association of Urinary N7-(1-hydroxyl-3-buten-1-yl) Guanine (EB-GII) Adducts and Butadiene-Mercapturic Acids with Lung Cancer Development in Cigarette Smokers	13
Correction to “Screening DNA Damage in the Rat Kidney and Liver by Untargeted DNA Adductomics”	13
Nicotinamide riboside Induced Energy Stress and Metabolic Reprogramming in BEAS-2B Cells	13
Berberine Inhibits KLF4 Promoter Methylation and Ferroptosis to Ameliorate Diabetic Nephropathy in Mice	13
Chlorobenzoquinones Aggravate RSL3-Induced Ferroptosis in ROS-Dependent Manner	12
Current Challenges to Align Inflammatory Key Events in Animals and Lung Cell Models In Vitro	12
A Weakly Supervised Deep Learning Framework for Whole Slide Classification to Facilitate Digital Pathology in Animal Study	12
Examining the Oxidation States of Metals in Aerosols Emitted by Electronic Cigarettes	12
Toxicity of Water- and Organic-Soluble Wood Tar Fractions from Biomass Burning in Lung Epithelial Cells	12
Carrier Solvents of Electronic Nicotine Delivery Systems Alter Pulmonary Surfactant	12
Short-Term Exposure to Foodborne Xenoestrogens Affects Breast Cancer Cell Morphology and Motility Relevant for Metastatic Behavior In Vitro	12
Mass Spectrometric Detection and Differentiation of Enzymatically Active Abrin and Ricin Combined with a Novel Affinity Enrichment Technique	12
Organophosphorus Pesticides Promote Protein Cross-Linking	12
Chemistry, Pharmacology, and Toxicology of Monoisoamyl Dimercaptosuccinic Acid: A Chelating Agent for Chronic Metal Poisoning	12
Automated Solid-Phase Microextraction and Negative Chemical Ionization GC-MS for the Measurement of Synthetic Pyrethroids	12
The Intercalator Ethidium Bromide Generates Covalent Adducts at Apurinic/Apyrimidinic Sites in DNA	12
Unraveling Interspecies Differences in the Phase I Hepatic Metabolism of Alternariol and Alternariol Monomethyl Ether: Closing Data Gaps for a Comprehensive Risk Assessment	12
Updating Reaction Mechanistic Domains for Skin Sensitization: 1. Nucleophilic Skin Sensitizers	12
The Selective SIRT3 Inhibitor 3-TYP Represses Primary Myeloma Growth by Reducing c-Myc Stability	12
A Review on the Recent Applications of Deep Learning in Predictive Drug Toxicological Studies	12
Reactivity of Acrylamides Causes Cytotoxicity and Activates Oxidative Stress Response	12
Using Rotenone to Model Parkinson’s Disease in Mice: A Review of the Role of Pharmacokinetics	11
Consensus Modeling for Predicting Chemical Binding to Transthyretin as the Winning Solution of the Tox24 Challenge	11
Surfactant Coformulants in Glyphosate-Based Herbicides: Current Gaps, and Paths Forward in Human Biomonitoring	11
Principal Metabolites in Extracts of Different Plants Responsible for Antibacterial Effects	11
Use of Cause-and-Effect Analysis to Optimize the Reliability of In Vitro Inhalation Toxicity Measurements Using an Air–Liquid Interface	11
Cardiotoxicity Hazard and Risk Characterization of ToxCast Chemicals Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes from Multiple Donors	11
Mechanistic Insights into Toxicity of Titanium Dioxide Nanoparticles at the Micro- and Macro-levels	11
Underlying Mechanisms of Allopurinol in Eliminating Renal Toxicity Induced by Melamine–Uric Acid Complex Formation: A Computational Study	11
Issue Publication Information	11
Chemical Research in Toxicology at 35: Recognizing the Impact of Professor Larry Marnett	11
Behavior Effects of Structurally Diverse Per- and Polyfluoroalkyl Substances in Zebrafish	11
Carbonyls and Aerosol Mass Generation from Vaping Nicotine Salt Solutions Using Fourth- and Third-Generation E-Cigarette Devices: Effects of Coil Resistance, Coil Age, and Coil Metal Material	11
RNA Methylation and Transcriptome Analysis Reveal Key Regulatory Pathways Related to Cadmium-Induced Liver Damage	11
Dedication of 35-year Chemical Research in Toxicology Anniversary to Founding Editor Larry Marnett	11
Dose-Dependent Molecular Responses of Labeo rohita to Triphenyl Phosphate	11
High Throughput Read-Across for Screening a Large Inventory of Related Structures by Balancing Artificial Intelligence/Machine Learning and Human Knowledge	10
Response to ‘Comments on “Tobacco-Specific Nitrosamines in the Tobacco and Mainstream Smoke of Commercial Little Cigars”’ Letter to Editor	10
Colletofragarone A2 Inhibits Cancer Cell Growth In Vivo and Leads to the Degradation and Aggregation of Mutant p53	10
Products Generated by Amine-Catalyzed Strand Cleavage at Apurinic/Apyrimidinic Sites in DNA: New Insights from a Biomimetic Nucleoside Model System	10
Chemical Exposures and Impact on Health	10

Repurposing the Antihypertensive Agent Hydralazine As an Inhibitor of the Base Excision Repair Enzyme APE1	10
Neutrophil Myeloperoxidase-Mediated N-Demethylation of Quetiapine Leads to N-Desalkylquetiapine, a Pharmacologically Active Cytochrome P450 Metabolite	10
(Q)SAR Approaches to Predict the Extent of Nitrosation in Pharmaceutical Compounds	10
Women in Toxicology Special Issue	10
Issue Editorial Masthead	10
Issue Editorial Masthead	10
Issue Editorial Masthead	10
Issue Editorial Masthead	10
Pesticides and the Gut Microbiota: Implications for Parkinson’s Disease	10
Acyl Glucuronide and Coenzyme A Thioester Metabolites of Carboxylic Acid-Containing Drug Molecules: Layering Chemistry with Reactive Metabolism and Toxicology	10
Issue Publication Information	10
Issue Editorial Masthead	10
Effects of Chemicals in Reporter Gene Bioassays with Different Metabolic Activities Compared to Baseline Toxicity	10
Using Proteins As Markers for Anabolic Steroid Abuse: A New Perspective in Doping Control?	10
Issue Publication Information	10
Computational Investigation of the Bisphenolic Drug Metabolism by Cytochrome P450: What Factors Favor Intramolecular Phenol Coupling	10
Adenanthin Is an Efficient Inhibitor of Peroxiredoxins from Pathogens, Inhibits Bacterial Growth, and Potentiates Antibiotic Activities	9
Latent Variables Capture Pathway-Level Points of Departure in High-Throughput Toxicogenomic Data	9
Nonylphenol Promoted Epithelial–Mesenchymal Transition in Colorectal Cancer Cells by Upregulating the Expression of Regulator of Cell Cycle	9
Characterization of Teicoplanin-Specific T-Cells from Drug Naïve Donors Expressing HLA-A*32:01	9
Chlorpyrifos Oxon Activates Glutamate and Lysine for Protein Cross-linking	9
A Classification Model to Identify Direct-Acting Mutagenic Polycyclic Aromatic Hydrocarbon Transformation Products	9
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced Histone Acetylation via α7nAChR-Mediated PI3K/Akt Activation and Its Impact on γ-H2AX Generation	9
The Human Glyoxalase Gene Family in Health and Disease	9
Chemical Interactions and Cytotoxicity of Terpene and Diluent Vaping Ingredients	9
Structural and Mechanistic Investigation of the Unusual Metabolism of Nifurtimox	9
Volatile Compound Emissions from Stereolithography Three-Dimensional Printed Cured Resin Models for Biomedical Applications	9
Identification of the Major Product of Guanine Oxidation in DNA by Ozone	9
A Comparative Metabolomics Approach Demonstrates That Octocrylene Accumulates in Stylophora pistillata Tissues as Derivatives and That Octocrylene Exposure Induces Mitochondrial Dysfunction and	9
In Vitro Evaluation of DNA Damage Effect Markers toward Five Nitrogen Mustards Based on Liquid Chromatography–Tandem Mass Spectrometry	9
Formation Mechanism and Toxicological Significance of Biogenic Mercury Selenide Nanoparticles in Human Hepatoma HepG2 Cells	9
Carbonyl Yields in Cigars under Three Smoking Regimens Using a Linear Smoking Machine	9
Chemical Modifications Induced by Phthalic Anhydride, a Respiratory Sensitizer, in Reconstructed Human Epidermis: A Combined HRMAS NMR and LC-MS/MS Proteomic Approach	9
Acrolein Increases the Pulmonary Tumorigenic Activity of the Tobacco-Specific Nitrosamine 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)	8
Pesticides Inhibit Retinoic Acid Catabolism in PLHC-1 and ZFL Fish Hepatic Cell Lines	8
State-Dependent Inhibition of Voltage-Gated Sodium Channels in Neuroblastoma Neuro-2A Cells by Arachidonic Acid from Halichondria okadai	8
Nonclinical Safety Signals in PharmaPendium Improve the Predictability of Human Drug-Induced Liver Injury	8
ZIM, a Norbornene Derived from 4-Aminoantipyrine, Induces DNA Damage and Cell Death but in Association Reduces the Effect of Commercial Chemotherapeutics	8
Current Approaches to COVID-19 Drug Discovery and Safety Assessment	8
Interview with Dr. Mingliang Fang, 2023 Young Investigator Award Recipient, American Chemical Society Division of Chemical Toxicology	8
Potential Involvement of Sulfotransferase in the Mechanism of Lamotrigine-induced Skin Rash	8
Probing the Role of CYP2 Enzymes in the Atropselective Metabolism of Polychlorinated Biphenyls Using Liver Microsomes from Transgenic Mouse Models	8
Effects of Diet on Aristolochic Acid-DNA Adduct Formation: Implications for Balkan Endemic Nephropathy Etiology	8
Mouth Level Intake of Nicotine from Three Brands of Little Filtered Cigars with Widely Differing Product Characteristics Among Adult Consumers	8
Autophagy Promotes α-Amanitin-Induced Apoptosis of Hepa1-6 Liver Cells	8
Leveraging Cell Painting Images to Expand the Applicability Domain and Actively Improve Deep Learning Quantitative Structure–Activity Relationship Models	8
Regulation of BTB (POZ) Structural Domain 6b by MicroRNA-222b in Zebrafish Embryos after Exposure to Di(2-ethylhexyl)phthalate at Low Concentrations	8
GeoDILI: A Robust and Interpretable Model for Drug-Induced Liver Injury Prediction Using Graph Neural Network-Based Molecular Geometric Representation	8
6-Formylindolo(3,2-b)carbazole Dampens Inflammation and Reduces Endotoxin-Induced Kidney Injury via Nrf2 Activation	8
Making the Case for Quantum Mechanics in Predictive Toxicology─Nearly 100 Years Too Late?	8
Mass Spectrometry-Based Metabolic Profiling of Urinary Metabolites of N′-Nitrosonornicotine (NNN) in the Rat	8
Integrative Analysis of Transcriptomic and Metabolomic Data for Identification of Pathways Related to Matrine-Induced Hepatotoxicity	8
Effects of a Second Local DNA Damage Event on the Toxicity of the Human Carcinogen 4-Aminobiphenyl: A Molecular Dynamics Study of a Damaged DNA Structure	8
Chemistry-Based Modeling on Phenotype-Based Drug-Induced Liver Injury Annotation: From Public to Proprietary Data	8
Variation of Benzo[a]pyrene, NNN, and NNK Levels in 16 Commercial Smokeless Tobacco Products	8
Identifying Differences in the Performance of Machine Learning Models for Off-Targets Trained on Publicly Available and Proprietary Data Sets	8
Evaluation of Six Aromatic Amines in the Mainstream Smoke of Commercial Cigars	8
Correction to Aberrant Cytokinesis and Cell Fusion Result in Multinucleation in HepG2 Cells Exposed to Silica Nanoparticles	8
Polyamine Adducts with AP Sites: Interaction with DNA Polymerases and AP Endonucleases	7
Infection with Human Papillomavirus 18 Promotes Alkylating Agent-Induced Malignant Transformation in a Human Esophageal Cell Line	7
Modeling the Toxicokinetics of Suspensions of Soluble Metallic Nanomaterials	7
8-OxodGuo and Fapy•dG Mutagenicity in Escherichia coli Increases Significantly when They Are Part of a Tandem Lesion with 5-Formyl-2′-deoxyuridine	7
High Levels of BPA and BPF Exposure during Pregnancy Are Associated with Lower Birth Weight in Shenyang in Northeast China	7
In Vitro, In Vivo, and In Silico Analysis of Pyraclostrobin and Cyprodinil and Their Mixture Reveal New Targets and Signaling Mechanisms	7
Structural Elucidation of Agrochemical Metabolic Transformation Products Based on Infrared Ion Spectroscopy to Improve In Silico Toxicity Assessment	7
Natural Product Baohuoside I Impairs the Stability and Membrane Location of MRP2 Reciprocally Regulated by SUMOylation and Ubiquitination in Hepatocytes	7
Design, Synthesis, and Biological Evaluation of New Oxadiazole Derivatives as Efficient Antihypertension Drugs	7
Practical Aspects of Flavin-Containing Monooxygenase-Mediated Metabolism	7
Introduction to the Special Issue: Mass Spectrometry Advances for Environmental and Human Health	7
Further Insights into the Oxidative Pathway of Thiocarbonyl-Type Antitubercular Prodrugs: Ethionamide, Thioacetazone, and Isoxyl	7
Metabolic Activation and Cytotoxicity of Labetalol Hydrochloride Mediated by Sulfotransferases	7
Perfluorotridecanoic Acid Inhibits Leydig Cell Maturation in Male Rats in Late Puberty via Changing Testicular Lipid Component	7
Psoralen and Isopsoralen, Two Estrogen-Like Natural Products from Psoraleae Fructus, Induced Cholestasis via Activation of ERK1/2	7
Trichloroethylene Metabolite S-(1,2-Dichlorovinyl)-l-cysteine Stimulates Changes in Energy Metabolites and Amino Acids in the BeWo Human Placental Trophoblast Model during Syncytiali	7
Photosensitized Oxidation of Free and Peptide Tryptophan to N-Formylkynurenine	7
Enantiomeric Fractions Reveal Differences in the Atropselective Disposition of 2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) in Wildtype, Cyp2abfgs-Null, and CYP2A6-Humanized Mice	7
Predicting the Mitochondrial Toxicity of Small Molecules: Insights from Mechanistic Assays and Cell Painting Data	7
Omeprazole-Associated Atypical Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) in a Patient with Positive In Vitro Diagnostic Testing to Multiple Proton Pump Inhibitors	7
Goniodomic Acid, a Transient Oxirane Intermediate in the Conversion of the Macrolide Algal Toxin Goniodomin A to Seco Acids	7
Quantum Mechanical Assessment of Nitrosamine Potency	7
Extracellular Vesicles from Human Plasma Show a Distinctive Proteome and miRNome Profile in Patients with Severe Cutaneous Adverse Reactions	7
Inhibition of CYP3A7 DHEA-S Oxidation by Lopinavir and Ritonavir: An Alternative Mechanism for Adrenal Impairment in HIV Antiretroviral-Treated Neonates	7
The Toxicity of Poly(acrylonitrile-styrene–butadiene) Microplastics toward Hyalella azteca Is Associated with Biofragmentation and Oxidative Stress	7
Prediction of Cytochrome P450 Substrates Using the Explainable Multitask Deep Learning Models	7
Deploying Validated Mass Spectrometry for Frontline Detection and Treatment of Human Poisoning by Long-Acting Anticoagulant Rodenticides	7
Characterization of Drug-Specific CD4⁺ T-Cells Reveals Possible Roles of HLA Class II in the Pathogenesis of Carbamazepine Hypersensitivity Reactions	7
Boronate-Based Oxidant-Responsive Derivatives of Acetaminophen as Proinhibitors of Myeloperoxidase	7
Informing Hazard Identification and Risk Characterization of Environmental Chemicals by Combining Transcriptomic and Functional Data from Human-Induced Pluripotent Stem-Cell-Derived Cardiomyocytes	7
Selective HLA Class II Allele-Restricted Activation of Atabecestat Metabolite-Specific Human T-Cells	7
Revealing Toxicological Mechanisms of Small Molecules Using Chemical Biology	7
Issue Publication Information	7
What to Expect When Expecting in Lab: A Review of Unique Risks and Resources for Pregnant Researchers in the Chemical Laboratory	6
Silver Nanoparticles Induced Metabolic Perturbations in Pseudomonas aeruginosa: Evaluation Using the UPLC-QTof-MS^E Platform	6
Searching for LINCS to Stress: Using Text Mining to Automate Reference Chemical Curation	6
MlrA, an Essential Enzyme for Microcystins and Nodularin on First Step Biodegradation in Microcystin-Degrading Bacteria	6