Journal of Clinical Epidemiology

Article	Citations
Incomplete reporting of adverse events in duloxetine trials: a meta-research survey of randomized controlled trials vs placebo	1563
A simulation study showed that linear regression and Mann-Whitney test can be used to analyze the days alive and at home by day 30 outcome in a randomized controlled trial	1452
How to use likelihood ratios to interpret evidence from randomized trials	211
Avoiding searching for outcomes called for additional search strategies: a study of Cochrane review searches	176
Measuring the environmental impact of health interventions in randomised controlled trials – a scoping review	164
Visualizing the value of diagnostic tests and prediction models, part II. Net benefit graphs: net benefit as a function of the exchange rate	156
Visualizing the value of diagnostic tests and prediction models, part III. Numerical example with discrete risk groups and miscalibration	148
Real-time adaptive randomization of clinical trials	137
Corrigendum to ‘Avoiding searching for outcomes called for additional search strategies: a study of cochrane review searches’ [Journal of Clinical Epidemiology, 149 (2022) 83-88]	130
Editing companies have the responsibility of ensuring their declared use of generative artificial intelligence	126
GRADE Notes 4: how to use GRADE when there is “no” evidence? A case study of using unpublished registry data	124
A systematic review of stepped wedge cluster randomized trials in high impact journals: assessing the design, rationale, and analysis	119
Editorial Board	103
Using Embase as a supplement to PubMed in Cochrane reviews differed across fields	95
Grading of recommendations assessment, development, and evaluation concept article 5: addressing intransitivity in a network meta-analysis	92
We extended the 2-week systematic review (2weekSR) methodology to larger, more complex systematic reviews: A case series	91
Evaluation of adherence to STARD for abstracts in a diverse sample of diagnostic accuracy abstracts published in 2012 and 2019 reveals suboptimal reporting practices	83
Variable selection methods were poorly reported but rarely misused in major medical journals: Literature review	82
Handling missing data in clinical research	80
Clinical trial data-sharing policies among journals, funding agencies, foundations, and other professional organizations: a scoping review	80
RETRACTED: Part II: a step-by-step guide to latent class analysis	79
Interrater reliability of ROB2 – an alternative measure and way of categorization	78
Retracted papers originating from paper mills: a cross-sectional analysis of references and citations	75
Leading pharmaceutical companies lacked transparency on clinical trials’ informed consent forms	74
Causal analyses with target trial emulation for real-world evidence removed large self-inflicted biases: systematic bias assessment of ovarian cancer treatment effectiveness	72

JBI series paper 3: The importance of people, process, evidence, and technology in pragmatic, healthcare provider-led evidence implementation	69
Systematic metareview of prediction studies demonstrates stable trends in bias and low PROBAST inter-rater agreement	69
Types and associated methodologies of overviews of reviews in health care: a methodological study with published examples	68
Letter to the editor: Does the origami plot really improve the radar plot? Authors’ further response to Boers	67
GRADE concept paper 2: Concepts for judging certainty on the calibration of prognostic models in a body of validation studies	67
Editorial Board	67
Substantial delays in clinical data published by the European Medicines Agency – a cross sectional study	67
Minimal important change thresholds change over time after knee and hip arthroplasty	66
Assessing conflict of interest reporting and quality of clinical trials on infant formula: a systematic review	66
Observational studies of antidepressant use and suicide risk are selectively published in psychiatric journals	64
Randomized COVID-19 vaccination rollout can offer direct real-world evidence	64
Editorial Board	63
Many thanks to our reviewers	63
Increased interaction and procedural flexibility favoured participation: Study across European cohorts of preterm born individuals	60
Table of Contents	58
Reporting of funding and conflicts of interest improved from preprints to peer-reviewed publications of biomedical research	58
Table of Contents	57
Editors’ choice: June 2022	56
Applying calculations to clinical medicine requires nuance: response to Uy	55
Development and validation of a prediction model for self-reported mobility decline in community-dwelling older adults	55
Understanding how deferred consent affects patient characteristics and outcomes: an exploratory analysis of a clinical trial of prone positioning for COVID-19	53
Practical guide to the typical analysis of prognostic factors and biomarkers without the use of P-values	52
Table of Contents	52
Quality of surgical patient-reported outcome measure validation studies is often deficient: a systematic review	50
Editorial Board	50
Empirical evaluation of the methods used in systematic reviews including observational studies and randomized trials	50
Imputing missing laboratory results may return erroneous values because they are not missing at random	48
Strong and high-quality evidence synthesis needs Cochrane: a statement of support by the GRADE Guidance Group	47
Published registry-based pharmacoepidemiologic associations show limited concordance with agnostic medication-wide analyses	46
Editorial Board	45
Quality assessment practice in systematic reviews of mediation studies: results from an overview of systematic reviews	45
Reporting transparency and completeness in trials: Paper 3 – trials conducted using administrative databases do not adequately report elements related to use of databases	44
The inclusion of outcomes in search strategies for Cochrane Reviews: authors’ reply	43
Editorial Board	42
Evidence-based social sciences in China Paper 1 : Introduction. Howard White	42
The construct of certainty of evidence has not been disseminated to systematic reviews and clinical practice guidelines; response to ‘The GRADE Working Group’ et al	41
Further advantages of publishing comprehensive directed acyclic graphs	41
The use of the GRADE dose–response gradient domain in nutrition evidence syntheses varies considerably	41
Assessing long-term effects after stem cell transplantation: design of the MOSA study	39
A scoping review reveals candidate quality indicators of knowledge translation and implementation science practice tools	38
The currency and completeness of specialized databases of COVID-19 publications	38
Editorial Board	38
Further reduction in statistical power for responder analysis of patient-reported outcomes with measurement error	37
Table of Contents	35
Table of Contents	35
Introducing article numbering to Journal of Clinical Epidemiology	35
Registered trials address questions already answered with high-certainty evidence: A sample of current redundant research	34
Reply to Kelly Farrah and David Kaunelis regarding our study “Validation of five search filters for retrieval of clinical practice guidelines produced low precision”	34
Measuring vaccine protection when the population is mostly vaccinated	33
Coronavirus disease 2019 scenarios for a long-term strategy under fundamental uncertainty	33

International application of PROMIS computerized adaptive tests: US versus country-specific item parameters can be consequential for individual patient scores	33
Cross-cultural adaptation and validation to Spanish of the PANELVIEW instrument to evaluate the health guidelines development process	32
Systematic Review Reveals Lack of Causal Methodology Applied to Pooled Longitudinal Observational Infectious Disease Studies	32
A cross-sectional study assessing visual abstracts of randomized trials revealed inadequate reporting and high prevalence of spin	32
Heterogeneous methodology in the development of patient versions of clinical practice guidelines: a scoping review	32
Stakeholder-informed positivity thresholds for disease markers and risk scores: a methodological framework and an application in obstructive lung disease	32
Table of Contents	32
Corrigendum to ‘Pilot and feasibility trials in surgery are incompletely reported according to the CONSORT checklist: a meta-research study’ [Journal of Clinical Epidemiology 170 (2024)]	31
Heterogeneity across outcomes in clinical trials on sodium-glucose cotransporter 2 inhibitors in chronic heart failure: a cross-sectional study	31
Simultaneous evaluation of the imprecision and inconsistency domains of GRADE can be performed using prediction intervals	31
Meta-analysis of individual participant data and informed consent: a small step, but important and neglected	31
Pilot and feasibility trials in surgery are incompletely reported according to the CONSORT checklist: a meta-research study	31
European non-commercial sponsors showed substantial variation in results reporting to the EU trial registry	31
Using preprints in evidence synthesis: Commentary on experience during the COVID-19 pandemic	30
Low-density lipoprotein cholesterol is not a successful surrogate endpoint: comment on Christensen et al.	30
Editors’ choice: April 2024	30
Challenges and solutions in prognostic prediction models in spinal disorders	29
Visual transformation for guidelines presentation of the strength of recommendations and the certainty of evidence	29
Beyond statistical significance: nuanced interpretations of statistically nonsignificant results were rare in Cochrane reviews – a metaepidemiological study	29
Noncollapsibility, confounding, and sparse-data bias. Part 1: The oddities of odds	29
A structured approach to information retrieval improved identification of funding and researchers’ conflicts of interest in trials included in Cochrane reviews	28
JBI series paper 2: tailored evidence synthesis approaches are required to answer diverse questions: a pragmatic evidence synthesis toolkit from JBI	28
Limited online training opportunities exist for scholarly peer reviewers	28
The walking man approach to interpreting the receiver operating characteristic curve and area under the receiver operating characteristic curve	27
Paper 5: a methodological overview of methods and interventions	27
The smallest worthwhile effect is superior to the MCID for estimating acceptable benefits of knee arthroplasty	27
Quasi-experiments are a valuable source of evidence about effects of interventions, programs and policies: commentary from the Campbell Collaboration Study Design and Bias Assessment Working Group	26
Systematic review automation tools improve efficiency but lack of knowledge impedes their adoption: a survey	26
Poor compliance of clinical trial registration among trials included in systematic reviews: a cohort study	26
A systematic survey identified methodological issues in studies estimating anchor-based minimal important differences in patient-reported outcomes	26
Guidance reconciliation and practice question prioritization for a World Health Organization's Ebola and Marburg Disease guideline	25
Why clinical context and relevant protocols matter: response to Impellizzeri et al.	25
Conceptualizing, operationalizing, and utilizing equity, diversity, and inclusion in clinical trials: a scoping review	25
Open science failed to penetrate academic hiring practices: a cross-sectional study	25
Predicting COVID-19 prognosis in the ICU remained challenging: external validation in a multinational regional cohort	25
Update of the agency for healthcare research and quality guidance on using nonrandomized studies in evidence syntheses	25
Trial sequential analysis involving same-year studies requires careful temporal ordering	25
Editorial Board	25
Editors’ Choice March 2025	25
Empirical estimation of disutilities and decision thresholds for composite endpoints	25
Developing reporting checklist items from systematic review findings: a roadmap and lessons to be learned from ACCORD	24
Values and preferences in COVID-19 public health guidelines: a systematic review	24
More than two-dozen prescription drug-based risk scores are available for risk adjustment: A systematic review	24
Required knowledge for guideline panel members to develop healthcare related testing recommendations: a developmental study	24
Analysis of risk of bias assessments in a sample of intervention systematic reviews, Part II: focus on risk of bias tools reveals few meet current appraisal standards	24
Screening colonoscopy similarly prevented distal and proximal colorectal cancer: a prospective study among 55–69-year-olds	24
Screening for diseases versus screening for health status	24
What should journals do to prevent the publication of methodologically flawed systematic reviews?	24
A methodological framework allows the identification of personomic markers to consider when designing personalized interventions	24
Analyses of academician cohorts generate biased pandemic excess death estimates	23
Urban RCT participants were healthier than non-participants or rural women	23
Overviews of reviews in the cardiovascular field underreported critical methodological and transparency characteristics: a methodological study based on the Preferred Reporting Items for Overviews of	23
Almost one in five physiotherapy trials excluded people due to lack of language proficiency: A meta-epidemiological study	23
Recruitment and implementation challenges were common in stepped-wedge cluster randomized trials: Results from a methodological review	22
Internal-external cross-validation helped to evaluate the generalizability of prediction models in large clustered datasets	22
Focus groups and interviews with the public led to the development of a template for a GRADE Plain Language Recommendation (PLR)	22
Unrestricted weighted least squares represent medical research better than random effects in 67,308 Cochrane meta-analyses	22
Recording harms in randomized controlled trials of behavior change interventions: a scoping review and map of the evidence	21
Supplementary strategies identified additional eligible studies in qualitative systematic reviews	21
The difference between evidence-based medicine, evidence-based (clinical) practice, and evidence-based health care	21
Regression-based prognostic models for functional independence after postacute brain injury rehabilitation are not transportable: a systematic review	21
Multimorbidity, activity limitation and self-reported health all predict mortality risk, but better measures were required	21
Use of GRADE in evidence syntheses published in high-impact-factor nutrition journals: A methodological survey	21
Librarian involvement in systematic reviews was associated with higher quality of reported search methods: a cross-sectional survey	21
In clinical trials, efficacy vs. effectiveness language is confusing	21
Clinical Epidemiology in China series. Paper 2: Promoting GRADE at the national level: The experience from China	20
A new method for synthesizing test accuracy data outperformed the bivariate method	20
Antidepressant prescriptions have not fully reflected evolving evidence from cumulative network meta-analyses and guideline recommendations	20
Cluster randomized trials of individual-level interventions were at high risk of bias	20
Allocation of scarce resources in a pandemic: rapid systematic review update of strategies for policymakers	20
Methodological review showed that time-to-event outcomes are often inadequately handled in cluster randomized trials	20
Metabolomics data complemented drug use information in epidemiological databases: pilot study of potential kidney donors	20
An international core outcome set for evaluating interventions to improve informed consent to clinical trials: The ELICIT Study	20
Results dissemination from completed clinical trials conducted at German university medical centers remained delayed and incomplete. The 2014 –2017 cohort	19
Secondary analysis of data from a core outcome set for burns demonstrated the need for involvement of lower income countries	19
Estimating power for clinical trials with Patient Reported Outcomes - using Item Response Theory	19
Review of pragmatic trials found that multiple primary outcomes are common but so too are discrepancies between protocols and final reports	19
ADL-dependent older adults were identified in medico-administrative databases	18
Imputing intracluster correlation coefficients from a posterior predictive distribution is a feasible method of dealing with unit of analysis errors in a meta-analysis of cluster RCTs	18
ADAPTE with modified Delphi supported developing a National Clinical Guideline: stratification of clinical risk in pregnancy	18

Reply to Hausner et al. Re: use of text mining tools in the development of search strategies—comparison of different approaches	18
Minimal important changes in standard deviation units are highly variable and no universally applicable value can be determined	18
Regression discontinuity analysis for pharmacovigilance: statin example reflected trial findings showing little evidence of harm	18
A review identified challenges distinguishing primary reports of randomized trials for meta-research: A proposal for improved reporting	17
A cause should not be automatically taken as an effect modifier of other causes: author's reply	17
Substantial heterogeneity found in reporting mortality in Cochrane systematic reviews and Core Outcome Sets in COMET database	17
Reporting and methodological quality of acupuncture network meta-analyses could be improved: an evidence mapping	17
A general explanation of the counterfactual definition of confounding	17
Three out of four published systematic reviews on COVID-19 treatments were not registered and one-third of those registered were published: a meta-research study	17
Awareness, value and use of the Australian living guidelines for the clinical care of people with COVID-19: an impact evaluation	17
Peering into the dark corners of knowledge synthesis to understand the influence of predatory journals on systematic reviews	17
Boys with overweight status lagged behind girls with overweight status in reading: evidence from mendelian randomization	16
Transportability of two heart failure trials to a disease registry using individual patient data	16
Validity of prognostic models of critical COVID-19 is variable. A systematic review with external validation	16
COVID-19 trials were not more likely to report intent to share individual data than non-COVID-19 trials in ClinicalTrials.gov	16
A Bayesian-adaptive decision-theoretic approach can reduce the sample sizes for multiarm exercise oncology trials	16
Large scoping reviews: managing volume and potential chaos in a pool of evidence sources	16
Methods used to conceptualize dimensions of health equity impacts of public health interventions in systematic reviews	16
How traditional informed consent impairs inclusivity in a learning healthcare system: lessons learned from the Utrecht Cardiovascular Cohort	16
Investigators' sense of failure thwarted transparency in clinical trials discontinued for poor recruitment	16
Statistical techniques to assess publication integrity in groups of randomized trials: a narrative review	16
Understanding variation in the results of real-world evidence studies that seem to address the same question	16
Persistent gender disparity in leading dental publications across 4 decades: an observational study	15
Advances in methodologies of negative controls: a scoping review	15
A systematic survey of adaptive trials shows substantial improvement in methods is needed	15
Paper 6: engaging racially and ethnically diverse interest holders in evidence syntheses	15
Reporting guidelines for traditional Chinese medicine could be improved: a cross-sectional study	15
Introducing the LATITUDES network: a library of assessment tools and training to improve transparency, utility and dissemination in evidence synthesis	15
GRADE guidance 23: considering cost-effectiveness evidence in moving from evidence to health-related recommendations	15
Substantial discrepancies exist between registered protocol and published manuscript in trials on exercise interventions for chronic low back pain: a metaresearch study	15
Risk of bias assessments in individual participant data meta-analyses of test accuracy and prediction models: a review shows improvements are needed	15
The complexity of the relationship between ethnicity and COVID-19 outcomes: author's reply	15
Validation of case-ascertainment algorithms using health administrative data to identify people who inject drugs in Ontario, Canada	15
Harms were detected but not reported in six clinical trials of gabapentin	15
Questionnaires assessing knowledge and beliefs about musculoskeletal conditions are potentially suitable for use, but further research is needed: a systematic review	15
The GRADE Working Group and CINeMA approaches provided inconsistent certainty of evidence ratings for a network meta-analysis of opioids for chronic noncancer pain	14
Pharmacovigilance studies without a priori hypothesis: systematic review highlights inappropriate multiple testing correction procedures	14
GRADE Concept 7: Issues and Insights Linking Guideline Recommendations to Trustworthy Essential Medicine Lists	14
Language restrictions in systematic reviews should not be imposed in the search strategy but in the eligibility criteria if necessary	14
Double-zero-event studies matter: A re-evaluation of physical distancing, face masks, and eye protection for preventing person-to-person transmission of COVID-19 and its policy impact	14
A Cross-sectional literature survey showed the reporting quality of multicenter randomized controlled trials should be improved	14
Statistical analysis of self-reported health conditions in cohort studies: handling of missing onset age	14
Design, methods, and reporting of impact studies of cardiovascular clinical prediction rules are suboptimal: a systematic review	14
Editors’ Choice: February 2025	14
Reporting transparency and completeness in trials: Paper 1: Introduction - Better reporting for disruptive clinical trials using routinely collected data	14
A taxonomy and framework for identifying and developing actionable statements in guidelines suggests avoiding informal recommendations	14
Resource use and costs of investigator-sponsored randomized clinical trials in Switzerland, Germany, and the United Kingdom: a metaresearch study	14
Corrigendum to ‘Identifying type 1 and 2 diabetes in research datasets where classification biomarkers are unavailable: assessing the accuracy of published approaches’ [Journal of Clinical Epidemiolog	14
Indirect effects in mediation analyses should not be tested for statistical significance	14
Indicators of questionable research practices were identified in 163,129 randomized controlled trials	14
Key concepts in clinical epidemiology: collider-conditioning bias	14
Minimal important difference estimates for patient-reported outcomes: A systematic survey	13
GRADE guidance 39: using GRADE-ADOLOPMENT to adopt, adapt or create contextualized recommendations from source guidelines and evidence syntheses	13
Identification of retracted publications and completeness of retraction notices in public health	13
Systematic review finds “spin” practices and poor reporting standards in studies on machine learning-based prediction models	13
Psychometric evaluation of a new drug-resistant tuberculosis stigma scale	13
No evidence of important difference in summary treatment effects between COVID-19 preprints and peer-reviewed publications: a meta-epidemiological study	13
Controversy and Debate: Questionable utility of the relative risk in clinical research: Paper 1: A call for change to practice	13
Large-scale validation of the prediction model risk of bias assessment Tool (PROBAST) using a short form: high risk of bias models show poorer discrimination	13
Cochrane's risk of bias tool for non-randomized studies (ROBINS-I) is frequently misapplied: A methodological systematic review	13
A systematic review finds a lack of consensus in methodological approaches in health inequality/inequity focused reviews	13
Equating and linking Patient-Reported Outcomes Measurement Information System 29-item questionnaire and 36-item Short-Form Health Survey domains using Rasch modeling	13
Complete case logistic regression with a dichotomised continuous outcome led to biased estimates	13
External validation of six COVID-19 prognostic models for predicting mortality risk in older populations in a hospital, primary care, and nursing home setting	13
Benchmarking Human–AI collaboration for common evidence appraisal tools	13
CONSORT Harms 2022 statement, explanation, and elaboration: updated guideline for the reporting of harms in randomized trials	13
International alliance and AGREE-ment of 71 clinical practice guidelines on the management of critical care patients with COVID-19: a living systematic review	13
Prospective registration of trials: where we are, why, and how we could get better	13
Methods for depicting overlap in overviews of systematic reviews: An introduction to static tabular and graphical displays	13
Research Integrity definitions and challenges	13
Text-mining in electronic healthcare records can be used as efficient tool for screening and data collection in cardiovascular trials: a multicenter validation study	13
Vital signs-based deterioration prediction model assumptions can lead to losses in prediction performance	13
Bridging disconnected networks of first and second lines of biologic therapies in rheumatoid arthritis with registry data: bayesian evidence synthesis with target trial emulation	13
Harms in Systematic Reviews Paper 2: Methods used to assess harms are neglected in systematic reviews of gabapentin	13
The patient engagement evaluation tool was valid for clinical practice guideline development	13
Searching two or more databases decreased the risk of missing relevant studies: a metaresearch study	13
External validation of clinical prediction models: simulation-based sample size calculations were more reliable than rules-of-thumb	13
Heterogeneity across outcomes reported in clinical trials for older adults with depression: a systematic survey	12
A conversation on health research collaborations and career with Dr. Gordon Guyatt: A commentary	12
Should We Formalise the Assessment of Clinical Heterogeneity /Diversity In Systematic Reviews	12
Clinical Epidemiology in China series. Paper 1: Evidence-based medicine in China: An oral history study	12
Operationalizing the GRADE-equity criterion to inform guideline recommendations: application to a medical cannabis guideline	12
Editors’ Choice: May 23	12
Mapping review could be seen as a subtype of scoping review and differentiating between the action of mapping evidence and presentation of evidence as maps may be helpful: response to Khalil et al	12
Table of Contents	12
Pearls on science, collaboration, and mentorship in health research: A masterclass conversation with Dr. John Ioannidis	12
Origami plot: a novel multivariate data visualization tool that improves radar chart	12
Social deprivation reduced registration for kidney transplantation through markers of nephrological care: a mediation analysis	12
Informing the GRADE evidence to decision process with health equity considerations: demonstration from the Canadian rheumatoid arthritis care context	12
Cross-classified multilevel models improved standard error estimates of covariates in clinical outcomes – a simulation study	12
Editorial Board	12
Assessment highlights need for improvement in standards of development of core outcome sets for rare genetic diseases	12
Statistical robustness of randomized controlled trials in high-impact journals has improved but was low across medical specialties	12
The GIN-McMaster guideline tool extension for the integration of quality improvement and quality assurance in guidelines: a description of the methods for its development	12
The DetectDeviatingCells algorithm was a useful addition to the toolkit for cellwise error detection in observational data	12