Journal of Autoimmunity

Article	Citations
Safety of biologic immunosuppressants in pregnant women with immune-mediated inflammatory diseases	388
GILZ regulates type I interferon release and sequesters STAT1	226
HNF4α, SP1 and c-myc are master regulators of CNS autoimmunity	188
Janus kinase inhibition prevents autoimmune diabetes in LEW.1WR1 rats	140
Consumption of complement in a 26-year-old woman with severe thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination	133
ATP-binding cassette G1 membrane transporter-mediated cholesterol efflux capacity influences coronary atherosclerosis and cardiovascular risk in Rheumatoid Arthritis	120
The universal effects of low-dose interleukin-2 across 13 autoimmune diseases in a basket clinical trial	115
Editorial Board	102
Advances in SLE classification criteria	102
Differences in innate immune cell populations distinguish autoimmune from herpesvirus-associated encephalitis	95
Clinical relevance of nitrated beta 2-glycoprotein I in antiphospholipid syndrome: Implications for thrombosis risk	93
Global and regional epidemiology of psoriatic arthritis in patients with psoriasis: A comprehensive systematic analysis and modelling study	89
Autoreactivity to self-antigens LL37 and ADAMTSL5 influences the clinical response to risankizumab in psoriatic patients	87
Disease activity in patients with immune-mediated inflammatory diseases after SARS-CoV-2 vaccinations	84
Breach of tolerance versus burden of bile acids: Resolving the conundrum in the immunopathogenesis and natural history of primary biliary cholangitis	80
Mesenchymal stromal cells-derived extracellular vesicles alleviate systemic sclerosis via miR-29a-3p	75
Autoimmune associated HLAs and T cell autoantigens exhibit common patterns across several autoimmune diseases	74
Ectopic CD4+ T cells in choroid plexus mediate neuropsychiatric lupus symptoms in mice via interferon-γ induced microglia activation	74
Tfh cell-derived small extracellular vesicles exacerbate the severity of collagen-induced arthritis by enhancing B-cell responses	73
Lupus nephritis: new progress in diagnosis and treatment	72
Autoantibodies against a subunit of mitochondrial respiratory chain complex I in inclusion body myositis	70
Targeting macrophages with phosphatidylserine-rich liposomes as a potential antigen-specific immunotherapy for type 1 diabetes	70
Interferon signatures fuel B cell hyperactivity and plasmablast expansion in systemic lupus erythematosus	66
Identification of the central tolerance checkpoint for autoreactive proteinase 3+ B cells in human bone marrow	63
Non-coding RNAs in immunoregulation and autoimmunity: Technological advances and critical limitations	60

Anti-annexin A4 antibody as a biomarker for desquamative interstitial pneumonia	60
Earlier vs. later time period of COVID-19 infection and emergent autoimmune signs, symptoms, and serologies	59
Glycobiology of psoriasis: A review	56
Editorial Board	55
Sunscreen use associated with elevated prevalence of anti-nuclear antibodies in U.S. adults	54
Editorial Board	53
Editorial Board	51
Cellular communication network factor 3 contributes to the pathological process of rheumatoid arthritis through promoting cell senescence and osteoclastogenesis in the joint	51
Post-translationally modified proteins bind and activate complement with implications for cellular uptake and autoantibody formation	48
Blood clots and bleeding events following BNT162b2 and ChAdOx1 nCoV-19 vaccine: An analysis of European data	48
Whole blood transcriptome identifies interferon-regulated genes as key drivers in thrombotic primary antiphospholipid syndrome	48
Antigenic mimicry – The key to autoimmunity in immune privileged organs	47
Assessment of the 2023 ACR/EULAR antiphospholipid syndrome classification criteria in a Chinese cohort: Impact on clinical practice	46
LAT1 enables T cell activation under inflammatory conditions	44
Intracellular virus sensor MDA5 mutation develops autoimmune myocarditis and nephritis	43
Genetic and transcriptomic analyses support a switch to lytic phase in Epstein Barr virus infection as an important driver in developing Systemic Lupus Erythematosus	43
Editorial Board	40
Mechanisms of Immunothrombosis in Vaccine-Induced Thrombotic Thrombocytopenia (VITT) Compared to Natural SARS-CoV-2 Infection	40
The complement system and human autoimmune diseases	40
Durable renal response and safety with add-on belimumab in patients with lupus nephritis in real-life setting (BeRLiSS-LN). Results from a large, nationwide, multicentric cohort	40
Impact of BNT162b2 mRNA anti-SARS-CoV-2 vaccine on interferon-alpha production by plasmacytoid dendritic cells and autoreactive T cells in patients with systemic lupus erythematosus: The COVALUS proje	39
Familial patterns of alopecia areata: A systematic review and meta-analysis	38
External and internal exposome as triggers of biological signalling in systemic sclerosis – A narrative synthesis	38
Peripheral immune profiling highlights a dynamic role of low-density granulocytes in myasthenia gravis	37
Clinical targeted treatment in Sjogren's disease: A systematic literature review for an evidence-based medicine approach	36
Long-term efficacy and safety of colchicine and anti-IL-1 blockers in FMF: results from the Eurofever multicenter observational study	36
The aryl hydrocarbon receptor in immune regulation and autoimmune pathogenesis	35
Autoimmune markers and vascular immune deposits in Finkelstein-Seidlmayer vasculitis: Systematic literature review	35
Antigen-specific immune reactions by expanded CD8+ T cell clones from HLA-B*27-positive patients with spondyloarthritis	34
Proprotein convertase subtilisin/kexin type 9 (PCSK9) levels in primary antiphospholipid syndrome. The multicenter ATHERO-APS study	33
Pregnancy-related complications in systemic lupus erythematosus	30
Renal and vascular outcomes in patients with isolated antiphospholipid syndrome nephropathy	30
The role of gut flora-driven Th cell responses in preclinical rheumatoid arthritis	30
Clinical utility of measuring CD4+ T follicular cells in patients with immune dysregulation	30
Differential changes in the gut microbiota between extrinsic and intrinsic atopic dermatitis	30
Single-cell sequencing of the retina shows that LDHA regulates pathogenesis of autoimmune uveitis	29
Autoantibodies in systemic lupus erythematosus: From immunopathology to therapeutic target	29
Silencing of aryl hydrocarbon receptor repressor restrains Th17 cell immunity in autoimmune hepatitis	29
Distinct gene dysregulation patterns herald precision medicine potentiality in systemic lupus erythematosus	28
LAMP3-mediated epithelial-mesenchymal transition promotes the invasion and excessive proliferation of fibroblast-like synoviocytes in rheumatoid arthritis	28
Modulation of PKM2 inhibits follicular helper T cell differentiation and ameliorates inflammation in lupus-prone mice	28
Interferon signature in giant cell arteritis aortitis	27
Autoantibodies against α-synuclein inhibit its aggregation and cytotoxicity	27
Recent advances in cutaneous lupus	25
Autoimmune hepatitis after SARS-CoV-2 vaccine: New-onset or flare-up?	25
Functional metagenomic analysis reveals potential inflammatory triggers associated with genetic risk for autoimmune disease	25
Environmental exposures as risk factors for idiopathic inflammatory myopathies	25
Coronavirus disease 2019, vaccination against coronavirus and immunoglobulin A-mediated diseases: systematic literature review	25
Does COVID-19 impact the prevalence of myositis specific antibodies in the Netherlands? A comparative nationwide study	25
T cell aging as a risk factor for autoimmunity	24

Acquired susceptibility to autoimmune diseases in pediatric patients with Escherichia coli infection: A population-matched retrospective cohort study	23
Anti-DNA antibody-targeted D-peptide nanoparticles ameliorate lupus nephritis in MRL/lpr mice	23
Altered lipid metabolism in synovial fibroblasts of individuals at risk of developing rheumatoid arthritis	23
Editorial Board	23
Interleukin 17-producing C-C motif chemokine receptor 6 + conventional CD4+ T cells are arthritogenic in an animal model of spondyloarthritis	22
Identifying the genetic association between systemic lupus erythematosus and the risk of autoimmune liver diseases	22
High T-cell response rate after COVID-19 vaccination in belimumab and rituximab recipients	22
Extracellular vesicle autoantibodies	22
Significance of anti-transcobalamin receptor antibodies in cutaneous arteritis revealed by proteome-wide autoantibody screening	22
High-content multimodal analysis supports the IL-7/IL-7 receptor axis as a relevant therapeutic target in primary Sjögren's syndrome	22
2023 International Consensus Guidance for the use of Tripterygium Wilfordii Hook F in the treatment of active rheumatoid arthritis	21
RNA-binding protein hnRNP UL1 binds κB sites to attenuate NF-κB-mediated inflammation	21
Pro-fibrotic effect of the susceptible gene PCSK5 in vascular fibrosis of Takayasu arteritis via TGF-β and SMAD3 signaling pathway activation	21
JAK inhibitors in refractory juvenile rheumatic diseases: Efficacy, tolerance and type-I interferon profiling, a single center retrospective study	21
T follicular helper cells in autoimmune diseases	20
Autoimmune diseases and the risk of bladder cancer: A Mendelian randomization analysis	20
Interleukin-15 is a hair follicle immune privilege guardian	20
Comprehensive description of adult-onset Still's disease after COVID-19 vaccination	20
Gut microbiota in systemic lupus erythematosus: A fuse and a solution	20
Natural IgG protects against early dissemination of vesicular stomatitis virus	19
Multi-omics study reveals different pathogenesis of the generation of skin lesions in SLE and IDLE patients	19
Application of laboratory models for sarcoidosis research	19
Acute-type acquired hemophilia A after COVID-19 mRNA vaccine administration: A new disease entity?	19
Pin1 maintains the effector program of pathogenic Th17 cells in autoimmune neuroinflammation	19
CD72-semaphorin3A axis: A new regulatory pathway in systemic lupus erythematosus	19
Genetic and pharmacological targeting of GSDMD ameliorates systemic inflammation in macrophage activation syndrome	18
Insights into the knowledge of complex diseases: Environmental infectious/toxic agents as potential etiopathogenetic factors of systemic sclerosis	18
Suppression of YTHDF2 attenuates autoimmune hepatitis by expansion of myeloid-derived suppressor cells	18
Immunosuppression induces regression of fibrosis in primary biliary cholangitis with moderate-to-severe interface hepatitis	18
Fecal microbiota transplantation in the treatment of systemic lupus erythematosus: What we learnt from the explorative clinical trial	18
Telomeres: New players in immune-mediated inflammatory diseases?	18
VEXAS syndrome: A newly identified X-Linked hematoinflammatory disorder – A comprehensive overview of its genetic, molecular, inflammatory, and clinical landscape	18
A survey of ficolin-3 activity in Systemic Lupus Erythematosus reveals a link to hematological disease manifestations and autoantibody profile	18
Poorer survival for patients with inflammatory arthritis treated with immune checkpoint inhibitors for melanoma	17
Cytokine producing B-cells and their capability to polarize macrophages in giant cell arteritis	17
Amelioration of immunoglobulin A vasculitis by suppression of the pathological expansion of T follicular helper 17 cells	17
Corrigendum to “Cell surface-expressed Ro52/IgG/HLA-DR complex is targeted by autoantibodies in patients with inflammatory myopathies” [J. Autoimmun. 126 (2022) 102774]	17
Neutrophil activation biomarker pentraxin 3 for diagnosis and monitoring of macrophage activation syndrome occurrence in adult-onset Still's disease	17
Developmental drugs for sarcoidosis	17
Regulatory T cells effectively downregulate the autoimmune anti-MPO response and ameliorate anti-MPO induced glomerulonephritis in mice	17
Treatment of mixed connective tissue disease: A multicenter retrospective study	17
PD-1 antibody interactions with Fc gamma receptors enable PD-1 agonism to inhibit T cell activation – therapeutic implications for autoimmunity	17
A cluster of type II interferon-regulated genes associates with disease activity in patients with systemic lupus erythematosus	16
Outcome and prognosis of isolated carotid vasculitis	16
Leukocytoclastic vasculitis (cutaneous small-vessel vasculitis) after COVID-19 vaccination	16
Interferon (IFN)-stimulated gene 15: A novel biomarker for lymphoma development in Sjögren's syndrome	16
Comparative effectiveness of preventive treatment with dimethyl fumarate-loaded solid lipid nanoparticles and oral dimethyl fumarate in a mouse model of multiple sclerosis	16
Cognitive dysfunction in SLE: An understudied clinical manifestation	16
Elevated unphosphorylated STAT1 and IRF9 in T and B cells of primary sjögren's syndrome: Novel biomarkers for disease activity and subsets	16
Pathogenicity of functionally activated PD-1+CD8+ cells and counterattacks by muscular PD-L1 through IFNγ in myositis	16
Accelerated waning of immune responses to a third COVID-19 vaccination in patients with immune-mediated inflammatory diseases	16
PD1+ innate lymphoid cells 3 predict JAK-dependent inflammation in rheumatoid arthritis	16
Repeated immunization with ATRA-containing liposomal adjuvant transdifferentiates Th17 cells to a Tr1-like phenotype	15
PPARG-mediated autophagy activation alleviates inflammation in rheumatoid arthritis	15
Pre-existing conditions associated with post-acute sequelae of COVID-19	15
Autophagy pathways in autoimmune diseases	15
Autoimmune hepatitis following COVID-19 vaccination	15
Extracellular microRNAs induce dendritic cell-dependent joint inflammation and potentiate osteoclast differentiation via TLR7/8 engagement	15
Monoclonal antibodies from B cells of patients with anti-MDA5 antibody-positive dermatomyositis directly stimulate interferon gamma production	15
Trained innate immunity in response to nuclear antigens in systemic lupus erythematosus	14
Peripheral helper T cells in human diseases	14
Immune-mediated necrotizing myopathy: A comprehensive review of the pathogenesis, clinical features, and treatments	14
B cell-specific mAb–siRNA conjugates improve experimental myasthenia	14
Sonic hedgehog promotes synovial inflammation and articular damage through p38 mitogen-activated protein kinase signaling in experimental arthritis	14
COVID-19 infection among autoimmune rheumatic disease patients: Data from an observational study and literature review	14
Editorial Board	14
Risk factors for hypogammaglobulinemia and association with relapse and severe infections in ANCA-associated vasculitis: A cohort study	13
mTOR-dependent loss of PON1 secretion and antiphospholipid autoantibody production underlie autoimmunity-mediated cirrhosis in transaldolase deficiency	13
SARS-CoV-2 mRNA vaccines do not worsen autoimmunity in patients with autoimmune liver diseases	13
Diversity and function of regulatory T cells in health and autoimmune diseases	13
Flagellin-specific human CAR Tregs for immune regulation in IBD	13
Editorial Board	13
Modulating T-cell activation with antisense oligonucleotides targeting lymphocyte cytosolic protein 2	13
Editorial Board	13
Loss of function of XBP1 splicing activity of IRE1α favors B cell tolerance breakdown	13
Editorial Board	12
Anti-retinal immune response in sarcoid uveitis: A potential role for PCLO as an antigenic target	12
High throughput screening identifies repurposable drugs for modulation of innate and acquired immune responses	12
TIGIT-Fc fusion protein alleviates murine lupus nephritis through the regulation of SPI-B-PAX5-XBP1 axis-mediated B-cell differentiation	12
Cytokine receptor γc effectuates the generation of proinflammatory innate CD8 T cells by non-classical MHC-I molecules	12

Immune complexome analysis of a rich variety of serum immune complexes identifies disease-characteristic immune complex antigens in systemic sclerosis	12
Anti-Ro60 and anti-Ro52/TRIM21: Two distinct autoantibodies in systemic autoimmune diseases	12
Blockade of neutrophil extracellular trap components ameliorates cholestatic liver disease in Mdr2 (Abcb4) knockout mice	12
Transcriptomic analyses of lung tissues reveal key genes associated with progression of systemic sclerosis-interstitial lung disease (SSc-ILD)	12
Prioritization of infectious epitopes for translational investigation in type 1 diabetes etiology	12
Chronic inflammation and extracellular matrix-specific autoimmunity following inadvertent periarticular influenza vaccination	12
Autoreactive T cells targeting type II pneumocyte antigens in COVID-19 convalescent patients	12
Autoimmune hepatitis after COVID-19 vaccine – more than a coincidence	11
The risk of cancer in pediatric-onset immune-mediated inflammatory diseases – A nationwide study	11
Comparison of vaccine-induced thrombotic events between ChAdOx1 nCoV-19 and Ad26.COV.2.S vaccines	11
Melatonin synergistically potentiates the effect of methylprednisolone on reducing neuroinflammation in the experimental autoimmune encephalomyelitis mouse model of multiple sclerosis	11
Mepolizumab versus benralizumab for eosinophilic granulomatosis with polyangiitis (EGPA): A European real-life retrospective comparative study	11
A recommended paradigm for vaccination of rheumatic disease patients with the SARS-CoV-2 vaccine	11
Gut microbiome, metabolome, host immunity associated with inflammatory bowel disease and intervention of fecal microbiota transplantation	11
Effects of fecal microbiota transplant on DNA methylation in patients with systemic lupus erythematosus	11
Autoantibodies against the NineTeen complex and U5 RNP in systemic sclerosis	11
New insights into the taxonomy of autoimmune diseases based on polyautoimmunity	11
Editorial Board	11
Phosphatase control of cytokine-mediated overproduction of galactose-deficient IgA1, the main autoantigen in IgA nephropathy	11
Compositional and functional aberrance of the gut microbiota in treatment-naïve patients with primary Sjögren's syndrome	11
Perivascular B cells link intestinal angiogenesis to immunity and to the gut-brain axis during neuroinflammation	11
Novel and unique rheumatoid factors cross-react with viral epitopes in COVID-19	11
K2P2.1 is a regulator of inflammatory cell responses in idiopathic inflammatory myopathies	11
WTAP promotes the progression of ulcerative colitis by silencing the expression of CES2 through m6A modification	10
COVID-19 outcomes in giant cell arteritis and polymyalgia rheumatica versus rheumatoid arthritis: A national, multicenter, cohort study	10
Passive maternal immunity in children born to women with systemic autoimmune rheumatic disease – A case-control study	10
Sex differences in biomarkers and biologic mechanisms in psoriatic diseases and spondyloarthritis	10
SARS-CoV-2 vaccination and risk of severe COVID-19 outcomes in patients with autoimmune hepatitis	10
Neointimal myofibroblasts contribute to maintaining Th1/Tc1 and Th17/Tc17 inflammation in giant cell arteritis	10
Identification of a novel PDC-E2 epitope in primary biliary cholangitis: Application for engineered Treg therapy	10
Evolving understandings for the roles of non-coding RNAs in autoimmunity and autoimmune disease	10
Disease status in human and experimental arthritis, and response to TNF blockade, is associated with MHC class II invariant chain (CD74) isoform expression	10
Cognition following chimeric antigen receptor T-cell therapy: A systematic review	9
Supraphysiological FOXP3 expression in human CAR-Tregs results in improved stability, efficacy, and safety of CAR-Treg products for clinical application	9
ETS-1 facilitates Th1 cell-mediated mucosal inflammation in inflammatory bowel diseases through upregulating CIRBP	9
Adenosine-to-inosine RNA editing contributes to type I interferon responses in systemic sclerosis	9
Molecular signature of neutrophil extracellular trap mediating disease module in idiopathic inflammatory myopathy	9
Salivary gland epithelial cell in Sjögren's syndrome: Metabolic shift and altered mitochondrial morphology toward an innate immune cell function	9
Genetic association and differential expression of HLA Complex Group lncRNAs in pemphigus	9
Circulating immune profile in granulomatosis with polyangiitis reveals distinct patterns related to disease activity	9
Inflammatory disease status and response to TNF blockade are associated with mechanisms of endotoxin tolerance	9
Advanced pulmonary sarcoidosis	9
Evaluation of minor labial salivary gland focus score in Sjögren's disease using deep learning: a tool for more efficient diagnosis and future tissue biomarker discovery	9
Neutrophil-derived extracellular vesicles induce endothelial inflammation and damage through the transfer of miRNAs	9
Short term outcomes of COVID-19 in lupus: Propensity score matched analysis from a nationwide multi-centric research network	9
Signal responses to neutral TSH receptor antibody – A cycle of damage in the pathophysiology of Graves’ disease	9
Conformational state of C-reactive protein is critical for reducing immune complex-triggered type I interferon response: Implications for pathogenic mechanisms in autoimmune diseases imprinted by type	9
Autoantibodies against ACE2 and angiotensin type-1 receptors increase severity of COVID-19	9
Butyrophilin 2a2 (Btn2a2) expression on thymic epithelial cells promotes central T cell tolerance and prevents autoimmune disease	9
The emerging role of BLyS/APRIL in autoimmune diseases: Biological characteristics, functions, and therapeutic potential	9
Circulating T cells in sarcoidosis have an aberrantly activated phenotype that correlates with disease outcome	9
miR-143-3p boosts extracellular vesicles to improve the dermal fibrosis of localized scleroderma	9
Alopecia Areata: Case report and review of pathophysiology and treatment with Jak inhibitors	9
Control of naive and effector CD4 T cell receptor repertoires by rheumatoid-arthritis-risk HLA alleles	9
SB431542 alleviates lupus nephritis by regulating B cells and inhibiting the TLR9/TGFβ1/PDGFB signaling	9
Isolation and characterisation of PR3-specific B cells and their immunoglobulin sequences	9
Old known and possible new biomarkers of ANCA-associated vasculitis	9
Editorial Board	9
Neuropsychiatric lupus erythematosus: Focusing on autoantibodies	8
IL-17 is expressed on beta and alpha cells of donors with type 1 and type 2 diabetes	8
LIGHT signaling through LTβR and HVEM in keratinocytes promotes psoriasis and atopic dermatitis-like skin inflammation	8
Single-cell analysis highlights a population of Th17-polarized CD4+ naïve T cells showing IL6/JAK3/STAT3 activation in pediatric severe aplastic anemia	8
Fecal microbiota transplantation for the management of autoimmune diseases: Potential mechanisms and challenges	8
Increased RNA editing sites revealed as potential novel biomarkers for diagnosis in primary Sjögren's syndrome	8
Editorial Board	8
A framework for exclusion of alternative diagnoses in sarcoidosis	8
Exercise, autoimmune diseases and T-regulatory cells	8
Associations between domestic hard water exposure and incident psoriasis in adults: Insights from the UK Biobank cohort study	8
Sarcoidosis and its relation to other immune-mediated diseases: Epidemiological insights	8
Editorial Board	8
Immune recognition of lysyl-tRNA synthetase and isoleucyl-tRNA synthetase by anti-OJ antibody-positive sera	8
CD72 is an inhibitory pattern recognition receptor that recognizes ribosomes and suppresses production of anti-ribosome autoantibody	8
Divergent regulatory T cell responses to high-dose methylprednisolone and tocilizumab in giant cell arteritis	8
Involvement of trained immunity during autoimmune responses	8
Lung transplantation in pulmonary sarcoidosis	8
Renoprotective anti-CD45RB antibody induces B cell production in systemic lupus erythematosus based on single-cell RNA-seq analysis	8
Editorial Board	8
Caspase-10 affects the pathogenesis of primary biliary cholangitis by regulating inflammatory cell death	8
Soluble form of immune checkpoints in autoimmune diseases	8
Citrullination of myelin basic protein induces a Th17-cell response in healthy individuals and enhances the presentation of MBP85-99 in patients with multiple sclerosis	7
Role of mitochondria in the myopathy of juvenile dermatomyositis and implications for skeletal muscle calcinosis	7
Integrative single-cell analysis reveals distinct adaptive immune signatures in the cutaneous lesions of pemphigus	7
Synovial regulatory T cells expressing ST2 deteriorate joint inflammation through the suppression of immunoregulatory eosinophils	7
Total lung capacity is predictive of disease severity and survival in systemic sclerosis: A longitudinal analysis in 2347 patients from the French National Cohort Study	7
Association between autoimmune diseases and glucagon-like peptide-1 receptor agonists: A real-world evidence study	7
Gut dysbiosis promotes islet-autoimmunity by increasing T-cell attraction in islets via CXCL10 chemokine	7
Engineered Treg cells: The heir to the throne of immunotherapy	7
Infectious diseases, autoantibodies, and autoimmunity	7
Editorial Board	7
Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner	7
Rapamycin nanoparticles increase the therapeutic window of engineered interleukin-2 and drive expansion of antigen-specific regulatory T cells for protection against autoimmune disease	7
Tissue-resident memory T cells: The key frontier in local synovitis memory of rheumatoid arthritis	7
Abnormalities of T cells in systemic lupus erythematosus: new insights in pathogenesis and therapeutic strategies	7
Machine learning approach to single cell transcriptomic analysis of Sjogren's disease reveals altered activation states of B and T lymphocytes	7
Impaired central tolerance induces changes in the gut microbiota that exacerbate autoimmune hepatitis	7