Journal of Autoimmunity

Article	Citations
Safety of biologic immunosuppressants in pregnant women with immune-mediated inflammatory diseases	418
Janus kinase inhibition prevents autoimmune diabetes in LEW.1WR1 rats	191
GILZ regulates type I interferon release and sequesters STAT1	158
HNF4α, SP1 and c-myc are master regulators of CNS autoimmunity	152
Advances in SLE classification criteria	130
ATP-binding cassette G1 membrane transporter-mediated cholesterol efflux capacity influences coronary atherosclerosis and cardiovascular risk in Rheumatoid Arthritis	130
The universal effects of low-dose interleukin-2 across 13 autoimmune diseases in a basket clinical trial	126
Breach of tolerance versus burden of bile acids: Resolving the conundrum in the immunopathogenesis and natural history of primary biliary cholangitis	109
Editorial Board	105
Autoreactivity to self-antigens LL37 and ADAMTSL5 influences the clinical response to risankizumab in psoriatic patients	100
Immunological and fibrotic profiling in the NOD.c3c4 murine model of autoimmune cholangitis	96
Differences in innate immune cell populations distinguish autoimmune from herpesvirus-associated encephalitis	94
Global and regional epidemiology of psoriatic arthritis in patients with psoriasis: A comprehensive systematic analysis and modelling study	94
Disease activity in patients with immune-mediated inflammatory diseases after SARS-CoV-2 vaccinations	87
Ectopic CD4+ T cells in choroid plexus mediate neuropsychiatric lupus symptoms in mice via interferon-γ induced microglia activation	77
Tfh cell-derived small extracellular vesicles exacerbate the severity of collagen-induced arthritis by enhancing B-cell responses	76
Autoimmune associated HLAs and T cell autoantigens exhibit common patterns across several autoimmune diseases	73
Lupus nephritis: new progress in diagnosis and treatment	72
Anti-annexin A4 antibody as a biomarker for desquamative interstitial pneumonia	55
Post-translationally modified proteins bind and activate complement with implications for cellular uptake and autoantibody formation	53
Editorial Board	51
Editorial Board	51
Interferon signatures fuel B cell hyperactivity and plasmablast expansion in systemic lupus erythematosus	50
Editorial Board	49
Glycobiology of psoriasis: A review	49

Sunscreen use associated with elevated prevalence of anti-nuclear antibodies in U.S. adults	46
Identification of the central tolerance checkpoint for autoreactive proteinase 3+ B cells in human bone marrow	45
Autoantibodies against a subunit of mitochondrial respiratory chain complex I in inclusion body myositis	45
Cellular communication network factor 3 contributes to the pathological process of rheumatoid arthritis through promoting cell senescence and osteoclastogenesis in the joint	45
Antigenic mimicry – The key to autoimmunity in immune privileged organs	43
Earlier vs. later time period of COVID-19 infection and emergent autoimmune signs, symptoms, and serologies	39
FAPI PET/CT for tracking disease trajectory in myositis-related interstitial lung disease	39
Targeting macrophages with phosphatidylserine-rich liposomes as a potential antigen-specific immunotherapy for type 1 diabetes	38
Whole blood transcriptome identifies interferon-regulated genes as key drivers in thrombotic primary antiphospholipid syndrome	38
Non-coding RNAs in immunoregulation and autoimmunity: Technological advances and critical limitations	36
Mitochondrial dysfunction is a potential key mechanism for atherosclerosis predisposition in patients with systemic lupus erythematosus	35
Genetic and transcriptomic analyses support a switch to lytic phase in Epstein Barr virus infection as an important driver in developing Systemic Lupus Erythematosus	35
LAT1 enables T cell activation under inflammatory conditions	33
Intracellular virus sensor MDA5 mutation develops autoimmune myocarditis and nephritis	33
Assessment of the 2023 ACR/EULAR antiphospholipid syndrome classification criteria in a Chinese cohort: Impact on clinical practice	33
The complement system and human autoimmune diseases	32
Editorial Board	32
Renal and vascular outcomes in patients with isolated antiphospholipid syndrome nephropathy	31
Clinical targeted treatment in Sjogren's disease: A systematic literature review for an evidence-based medicine approach	31
Proprotein convertase subtilisin/kexin type 9 (PCSK9) levels in primary antiphospholipid syndrome. The multicenter ATHERO-APS study	30
External and internal exposome as triggers of biological signalling in systemic sclerosis – A narrative synthesis	30
Single-cell sequencing of the retina shows that LDHA regulates pathogenesis of autoimmune uveitis	30
Autoimmune markers and vascular immune deposits in Finkelstein-Seidlmayer vasculitis: Systematic literature review	29
Impact of BNT162b2 mRNA anti-SARS-CoV-2 vaccine on interferon-alpha production by plasmacytoid dendritic cells and autoreactive T cells in patients with systemic lupus erythematosus: The COVALUS proje	29
Familial patterns of alopecia areata: A systematic review and meta-analysis	29
Distinct gene dysregulation patterns herald precision medicine potentiality in systemic lupus erythematosus	27
Clinical utility of measuring CD4+ T follicular cells in patients with immune dysregulation	27
The role of gut flora-driven Th cell responses in preclinical rheumatoid arthritis	27
Peripheral immune profiling highlights a dynamic role of low-density granulocytes in myasthenia gravis	27
Autoantibodies in systemic lupus erythematosus: From immunopathology to therapeutic target	26
The aryl hydrocarbon receptor in immune regulation and autoimmune pathogenesis	26
Pregnancy-related complications in systemic lupus erythematosus	26
Antigen-specific immune reactions by expanded CD8+ T cell clones from HLA-B*27-positive patients with spondyloarthritis	26
Long-term efficacy and safety of colchicine and anti-IL-1 blockers in FMF: results from the Eurofever multicenter observational study	26
Modulation of PKM2 inhibits follicular helper T cell differentiation and ameliorates inflammation in lupus-prone mice	26
Differential changes in the gut microbiota between extrinsic and intrinsic atopic dermatitis	25
Autoantibodies against α-synuclein inhibit its aggregation and cytotoxicity	25
Silencing of aryl hydrocarbon receptor repressor restrains Th17 cell immunity in autoimmune hepatitis	25
Functional metagenomic analysis reveals potential inflammatory triggers associated with genetic risk for autoimmune disease	25
Coronavirus disease 2019, vaccination against coronavirus and immunoglobulin A-mediated diseases: systematic literature review	24
Temporal trajectories and DMARD therapy retention of rheumatoid arthritis patients with different autoimmune and inflammatory comorbidity profiles: a retrospective analysis	23
Environmental exposures as risk factors for idiopathic inflammatory myopathies	23
Alternate splicing converts human CD137 from costimulatory to immunosuppressive function	23
Does COVID-19 impact the prevalence of myositis specific antibodies in the Netherlands? A comparative nationwide study	23
LAMP3-mediated epithelial-mesenchymal transition promotes the invasion and excessive proliferation of fibroblast-like synoviocytes in rheumatoid arthritis	23
T cell aging as a risk factor for autoimmunity	22
Evaluation of the mycophenolate mofetil–rituximab combination in systemic sclerosis: a French retrospective multicenter study (MycRiSSc)	22
Interferon signature in giant cell arteritis aortitis	22
Recent advances in cutaneous lupus	22
Altered lipid metabolism in synovial fibroblasts of individuals at risk of developing rheumatoid arthritis	22

Editorial Board	21
Pro-fibrotic effect of the susceptible gene PCSK5 in vascular fibrosis of Takayasu arteritis via TGF-β and SMAD3 signaling pathway activation	21
High T-cell response rate after COVID-19 vaccination in belimumab and rituximab recipients	21
Extracellular vesicle autoantibodies	20
Gut microbiota in systemic lupus erythematosus: A fuse and a solution	20
High-content multimodal analysis supports the IL-7/IL-7 receptor axis as a relevant therapeutic target in primary Sjögren's syndrome	20
Interleukin 17-producing C-C motif chemokine receptor 6 + conventional CD4+ T cells are arthritogenic in an animal model of spondyloarthritis	20
Acquired susceptibility to autoimmune diseases in pediatric patients with Escherichia coli infection: A population-matched retrospective cohort study	20
Methotrexate and low-dose prednisone in idiopathic retroperitoneal fibrosis: a randomised clinical trial	19
Interleukin-15 is a hair follicle immune privilege guardian	19
RNA-binding protein hnRNP UL1 binds κB sites to attenuate NF-κB-mediated inflammation	19
Identifying the genetic association between systemic lupus erythematosus and the risk of autoimmune liver diseases	19
Significance of anti-transcobalamin receptor antibodies in cutaneous arteritis revealed by proteome-wide autoantibody screening	19
JAK inhibitors in refractory juvenile rheumatic diseases: Efficacy, tolerance and type-I interferon profiling, a single center retrospective study	19
Anti-DNA antibody-targeted D-peptide nanoparticles ameliorate lupus nephritis in MRL/lpr mice	19
Preliminary safety and efficacy of relmacabtagene autoleucel (relma-cel) in adults with moderately to severely active systemic lupus erythematosus: a phase I dose-escalation study	19
2023 International Consensus Guidance for the use of Tripterygium Wilfordii Hook F in the treatment of active rheumatoid arthritis	18
CD72-semaphorin3A axis: A new regulatory pathway in systemic lupus erythematosus	18
Autoimmune diseases and the risk of bladder cancer: A Mendelian randomization analysis	18
T follicular helper cells in autoimmune diseases	18
Application of laboratory models for sarcoidosis research	18
A survey of ficolin-3 activity in Systemic Lupus Erythematosus reveals a link to hematological disease manifestations and autoantibody profile	18
Pin1 maintains the effector program of pathogenic Th17 cells in autoimmune neuroinflammation	18
Immunosuppression induces regression of fibrosis in primary biliary cholangitis with moderate-to-severe interface hepatitis	18
Natural IgG protects against early dissemination of vesicular stomatitis virus	18
Comprehensive description of adult-onset Still's disease after COVID-19 vaccination	17
Genetic and pharmacological targeting of GSDMD ameliorates systemic inflammation in macrophage activation syndrome	17
Altered glucose metabolism in B cells: Implications for the pathogenesis and treatment of autoimmune diseases	17
Accelerated waning of immune responses to a third COVID-19 vaccination in patients with immune-mediated inflammatory diseases	17
Multi-omics study reveals different pathogenesis of the generation of skin lesions in SLE and IDLE patients	17
Fecal microbiota transplantation in the treatment of systemic lupus erythematosus: What we learnt from the explorative clinical trial	17
VEXAS syndrome: A newly identified X-Linked hematoinflammatory disorder – A comprehensive overview of its genetic, molecular, inflammatory, and clinical landscape	17
Acute-type acquired hemophilia A after COVID-19 mRNA vaccine administration: A new disease entity?	17
Association between age groups and relapse of type 1 autoimmune pancreatitis: a large-scale retrospective cohort study	17
Cytokine producing B-cells and their capability to polarize macrophages in giant cell arteritis	17
Suppression of YTHDF2 attenuates autoimmune hepatitis by expansion of myeloid-derived suppressor cells	17
Chimeric antigen receptor T cell therapy: a new frontier therapeutic landscape in autoimmune diseases	16
Poorer survival for patients with inflammatory arthritis treated with immune checkpoint inhibitors for melanoma	16
Leukocytoclastic vasculitis (cutaneous small-vessel vasculitis) after COVID-19 vaccination	16
Treatment of mixed connective tissue disease: A multicenter retrospective study	16
PD1+ innate lymphoid cells 3 predict JAK-dependent inflammation in rheumatoid arthritis	16
Corrigendum to “Cell surface-expressed Ro52/IgG/HLA-DR complex is targeted by autoantibodies in patients with inflammatory myopathies” [J. Autoimmun. 126 (2022) 102774]	16
Neutrophil activation biomarker pentraxin 3 for diagnosis and monitoring of macrophage activation syndrome occurrence in adult-onset Still's disease	16
Amelioration of immunoglobulin A vasculitis by suppression of the pathological expansion of T follicular helper 17 cells	16
Cognitive dysfunction in SLE: An understudied clinical manifestation	16
PD-1 antibody interactions with Fc gamma receptors enable PD-1 agonism to inhibit T cell activation – therapeutic implications for autoimmunity	16
Elevated unphosphorylated STAT1 and IRF9 in T and B cells of primary sjögren's syndrome: Novel biomarkers for disease activity and subsets	15
Regulatory T cells effectively downregulate the autoimmune anti-MPO response and ameliorate anti-MPO induced glomerulonephritis in mice	15
Sonic hedgehog promotes synovial inflammation and articular damage through p38 mitogen-activated protein kinase signaling in experimental arthritis	15
Autoimmune hepatitis following COVID-19 vaccination	15
Outcome and prognosis of isolated carotid vasculitis	15
A cluster of type II interferon-regulated genes associates with disease activity in patients with systemic lupus erythematosus	15
Pathogenicity of functionally activated PD-1+CD8+ cells and counterattacks by muscular PD-L1 through IFNγ in myositis	15
Developmental drugs for sarcoidosis	15
Comparative effectiveness of preventive treatment with dimethyl fumarate-loaded solid lipid nanoparticles and oral dimethyl fumarate in a mouse model of multiple sclerosis	15
Repeated immunization with ATRA-containing liposomal adjuvant transdifferentiates Th17 cells to a Tr1-like phenotype	15
Loss of function of XBP1 splicing activity of IRE1α favors B cell tolerance breakdown	14
Editorial Board	14
The double-edged sword role of copper in rheumatoid arthritis: Mechanisms, therapeutics, and challenges	14
Monoclonal antibodies from B cells of patients with anti-MDA5 antibody-positive dermatomyositis directly stimulate interferon gamma production	14
Flagellin-specific human CAR Tregs for immune regulation in IBD	14
Extracellular microRNAs induce dendritic cell-dependent joint inflammation and potentiate osteoclast differentiation via TLR7/8 engagement	14
Elderly-onset systemic sclerosis defines a distinct clinical subset: analysis from the SPRING registry of the Italian Society for Rheumatology	14
Pre-existing conditions associated with post-acute sequelae of COVID-19	14
Immune-mediated necrotizing myopathy: A comprehensive review of the pathogenesis, clinical features, and treatments	14
Autophagy pathways in autoimmune diseases	14
PPARG-mediated autophagy activation alleviates inflammation in rheumatoid arthritis	14
B cell-specific mAb–siRNA conjugates improve experimental myasthenia	13
Interpretation of the association between thyroid peroxidase antibodies and thyroid function during pregnancy: An individual participant data meta-analysis	13
Modulating T-cell activation with antisense oligonucleotides targeting lymphocyte cytosolic protein 2	13
Cytokine receptor γc effectuates the generation of proinflammatory innate CD8 T cells by non-classical MHC-I molecules	13
mTOR-dependent loss of PON1 secretion and antiphospholipid autoantibody production underlie autoimmunity-mediated cirrhosis in transaldolase deficiency	13
Trained innate immunity in response to nuclear antigens in systemic lupus erythematosus	13
Peripheral helper T cells in human diseases	13
Editorial Board	13
Prioritization of infectious epitopes for translational investigation in type 1 diabetes etiology	13
Diversity and function of regulatory T cells in health and autoimmune diseases	13
Risk factors for hypogammaglobulinemia and association with relapse and severe infections in ANCA-associated vasculitis: A cohort study	13
Anti-retinal immune response in sarcoid uveitis: A potential role for PCLO as an antigenic target	13
Autoreactive T cells targeting type II pneumocyte antigens in COVID-19 convalescent patients	13

How early-life adversity affects the risk of pediatric-onset immune-mediated inflammatory disease	12
Immune complexome analysis of a rich variety of serum immune complexes identifies disease-characteristic immune complex antigens in systemic sclerosis	12
Melatonin synergistically potentiates the effect of methylprednisolone on reducing neuroinflammation in the experimental autoimmune encephalomyelitis mouse model of multiple sclerosis	12
Editorial Board	12
Transcriptomic analyses of lung tissues reveal key genes associated with progression of systemic sclerosis-interstitial lung disease (SSc-ILD)	12
TIGIT-Fc fusion protein alleviates murine lupus nephritis through the regulation of SPI-B-PAX5-XBP1 axis-mediated B-cell differentiation	12
Blockade of neutrophil extracellular trap components ameliorates cholestatic liver disease in Mdr2 (Abcb4) knockout mice	12
Editorial Board	12
New insights into the taxonomy of autoimmune diseases based on polyautoimmunity	12
Treatment outcomes stratified by interferon profile and autoantibodies in rheumatoid arthritis	12
Mepolizumab versus benralizumab for eosinophilic granulomatosis with polyangiitis (EGPA): A European real-life retrospective comparative study	12
Neointimal myofibroblasts contribute to maintaining Th1/Tc1 and Th17/Tc17 inflammation in giant cell arteritis	11
SARS-CoV-2 mRNA vaccines do not worsen autoimmunity in patients with autoimmune liver diseases	11
High throughput screening identifies repurposable drugs for modulation of innate and acquired immune responses	11
Evolving understandings for the roles of non-coding RNAs in autoimmunity and autoimmune disease	11
Autoantibodies against the NineTeen complex and U5 RNP in systemic sclerosis	11
Effects of fecal microbiota transplant on DNA methylation in patients with systemic lupus erythematosus	11
K2P2.1 is a regulator of inflammatory cell responses in idiopathic inflammatory myopathies	11
Targeted protein degradation in autoimmune diseases: from mechanisms to therapeutic breakthroughs	11
Perivascular B cells link intestinal angiogenesis to immunity and to the gut-brain axis during neuroinflammation	11
Sex differences in biomarkers and biologic mechanisms in psoriatic diseases and spondyloarthritis	11
The risk of cancer in pediatric-onset immune-mediated inflammatory diseases – A nationwide study	11
Gut microbiome, metabolome, host immunity associated with inflammatory bowel disease and intervention of fecal microbiota transplantation	11
Novel and unique rheumatoid factors cross-react with viral epitopes in COVID-19	11
Phosphatase control of cytokine-mediated overproduction of galactose-deficient IgA1, the main autoantigen in IgA nephropathy	11
WTAP promotes the progression of ulcerative colitis by silencing the expression of CES2 through m6A modification	11
Compositional and functional aberrance of the gut microbiota in treatment-naïve patients with primary Sjögren's syndrome	11
SB431542 alleviates lupus nephritis by regulating B cells and inhibiting the TLR9/TGFβ1/PDGFB signaling	10
Identification of a novel PDC-E2 epitope in primary biliary cholangitis: Application for engineered Treg therapy	10
Disease status in human and experimental arthritis, and response to TNF blockade, is associated with MHC class II invariant chain (CD74) isoform expression	10
Evaluation of minor labial salivary gland focus score in Sjögren's disease using deep learning: a tool for more efficient diagnosis and future tissue biomarker discovery	10
Tlr9 expression protects against Tlr7-dependent exocrine gland and systemic disease manifestations in primary Sjögren's disease in a sex-biased manner	10
ETS-1 facilitates Th1 cell-mediated mucosal inflammation in inflammatory bowel diseases through upregulating CIRBP	10
Passive maternal immunity in children born to women with systemic autoimmune rheumatic disease – A case-control study	10
SARS-CoV-2 vaccination and risk of severe COVID-19 outcomes in patients with autoimmune hepatitis	10
Control of naive and effector CD4 T cell receptor repertoires by rheumatoid-arthritis-risk HLA alleles	10
Signal responses to neutral TSH receptor antibody – A cycle of damage in the pathophysiology of Graves’ disease	10
Molecular signature of neutrophil extracellular trap mediating disease module in idiopathic inflammatory myopathy	10
COVID-19 outcomes in giant cell arteritis and polymyalgia rheumatica versus rheumatoid arthritis: A national, multicenter, cohort study	10
Alopecia Areata: Case report and review of pathophysiology and treatment with Jak inhibitors	10
miR-143-3p boosts extracellular vesicles to improve the dermal fibrosis of localized scleroderma	10
Salivary gland epithelial cell in Sjögren's syndrome: Metabolic shift and altered mitochondrial morphology toward an innate immune cell function	9
CD72 is an inhibitory pattern recognition receptor that recognizes ribosomes and suppresses production of anti-ribosome autoantibody	9
Butyrophilin 2a2 (Btn2a2) expression on thymic epithelial cells promotes central T cell tolerance and prevents autoimmune disease	9
The emerging role of BLyS/APRIL in autoimmune diseases: Biological characteristics, functions, and therapeutic potential	9
Advanced pulmonary sarcoidosis	9
The concept of severity in psoriatic arthritis: a scoping review of the literature	9
Cognition following chimeric antigen receptor T-cell therapy: A systematic review	9
Circulating immune profile in granulomatosis with polyangiitis reveals distinct patterns related to disease activity	9
Inflammatory disease status and response to TNF blockade are associated with mechanisms of endotoxin tolerance	9
Conformational state of C-reactive protein is critical for reducing immune complex-triggered type I interferon response: Implications for pathogenic mechanisms in autoimmune diseases imprinted by type	9
Fecal microbiota transplantation for the management of autoimmune diseases: Potential mechanisms and challenges	9
Supraphysiological FOXP3 expression in human CAR-Tregs results in improved stability, efficacy, and safety of CAR-Treg products for clinical application	9
Circulating T cells in sarcoidosis have an aberrantly activated phenotype that correlates with disease outcome	9
Neutrophil-derived extracellular vesicles induce endothelial inflammation and damage through the transfer of miRNAs	9
Editorial Board	9
Old known and possible new biomarkers of ANCA-associated vasculitis	9
Isolation and characterisation of PR3-specific B cells and their immunoglobulin sequences	9
The immunomodulatory roles of the gut microbiome in autoimmune diseases of the central nervous system: Multiple sclerosis as a model	8
Lung transplantation in pulmonary sarcoidosis	8
Associations between domestic hard water exposure and incident psoriasis in adults: Insights from the UK Biobank cohort study	8
Soluble form of immune checkpoints in autoimmune diseases	8
Neuropsychiatric lupus erythematosus: Focusing on autoantibodies	8
Increased RNA editing sites revealed as potential novel biomarkers for diagnosis in primary Sjögren's syndrome	8
Decoding CD4+ T cell transcriptome in giant cell arteritis: Novel pathways and altered cross-talk with monocytes	8
Role of mitochondria in the myopathy of juvenile dermatomyositis and implications for skeletal muscle calcinosis	8
Renoprotective anti-CD45RB antibody induces B cell production in systemic lupus erythematosus based on single-cell RNA-seq analysis	8
A novel subset of inflammation-related liver NK cells modulates immune responses in a murine model of primary biliary cholangitis	8
Editorial Board	8
Involvement of trained immunity during autoimmune responses	8
Single-cell analysis highlights a population of Th17-polarized CD4+ naïve T cells showing IL6/JAK3/STAT3 activation in pediatric severe aplastic anemia	8
The cancer-associated glycan polysialic acid is dysregulated in systemic sclerosis and is associated with fibrosis	8
Autoreactive B cells remain active despite clinical disease control in rheumatoid arthritis	8
Caspase-10 affects the pathogenesis of primary biliary cholangitis by regulating inflammatory cell death	8
Sarcoidosis and its relation to other immune-mediated diseases: Epidemiological insights	8
Divergent regulatory T cell responses to high-dose methylprednisolone and tocilizumab in giant cell arteritis	8
A framework for exclusion of alternative diagnoses in sarcoidosis	8
LIGHT signaling through LTβR and HVEM in keratinocytes promotes psoriasis and atopic dermatitis-like skin inflammation	8
Citrullination of myelin basic protein induces a Th17-cell response in healthy individuals and enhances the presentation of MBP85-99 in patients with multiple sclerosis	7
Editorial Board	7
Research progress of single-cell transcriptome sequencing in autoimmune diseases and autoinflammatory disease: A review	7
Association between autoimmune diseases and glucagon-like peptide-1 receptor agonists: A real-world evidence study	7
Synovial regulatory T cells expressing ST2 deteriorate joint inflammation through the suppression of immunoregulatory eosinophils	7
Alterations of fecal microbiome and metabolome in pemphigus patients	7
Abnormalities of T cells in systemic lupus erythematosus: new insights in pathogenesis and therapeutic strategies	7
Editorial Board	7
Autoimmune and autoinflammatory conditions after COVID-19 vaccination. New case reports and updated literature review	7
Editorial Board	7
Machine learning approach to single cell transcriptomic analysis of Sjogren's disease reveals altered activation states of B and T lymphocytes	7
Exercise, autoimmune diseases and T-regulatory cells	7
Infectious diseases, autoantibodies, and autoimmunity	7
Impaired central tolerance induces changes in the gut microbiota that exacerbate autoimmune hepatitis	7
Systemic lupus erythematosus-complicating immune thrombocytopenia: From pathogenesis to treatment	7
Total lung capacity is predictive of disease severity and survival in systemic sclerosis: A longitudinal analysis in 2347 patients from the French National Cohort Study	7
Cannabinoid receptor 2 selective agonist alleviates systemic sclerosis by inhibiting Th2 differentiation through JAK/SOCS3 signaling	7