OOIR: Observatory of International Research

Papers

(The median citation count of Xenotransplantation is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
	109
Anatomical and Physiological Considerations for Pig Cardiac Xenotransplantation	38
Anti‐pig antibodies in swine veterinarian serum: Implications for clinical xenotransplantation	36
Systemic inflammation in the xenotransplant recipient (SIXR) can occur in the absence of pCMV infection	36
Scientific and psychosocial ethical considerations for initial clinical trials of kidney xenotransplantation	23
Hendrik Jan (Henk) Schuurman, MSc, PhD (1950–2024): In Memoriam	20
Xenotransplantation Literature Update July–December 2024	20
Transthoracic echocardiography is a simple tool for size matching in cardiac xenotransplantation	20
Invited commentary	19
Bioinformatic analysis as a first step to predict the compatibility of hematopoiesis and immune system genes between humans and pigs	18
First transplantation of a pig heart from a multiple gene‐modified donor, porcine cytomegalovirus/roseolovirus, and antiviral drugs	17
Impact of COVID‐19 Vaccination and Infection on Anti‐Triple‐Knockout (TKO) Pig Antibody Production: A Study in Patients With End‐Stage Liver Disease and Liver Transplant Recipients	16
Human erythrocyte fragmentation during ex‐vivo pig organ perfusion	15
RETRACTION: An IgM Cleaving Enzyme for Clearance of Anti‐Pig Xenoreactive Antibodies in a Nonhuman Primate Model	15
Heterogenous expression of endocrine and progenitor cells within the neonatal porcine pancreatic lobes–Implications for neonatal porcine islet xenotransplantation	14
ECG Features in Orthotopic Cardiac Xenotransplantation: Comparisons With Published Literature	13
hEPCR.hTBM.hCD47.hHO‐1 with donor clodronate and DDAVP treatment improves perfusion and function of GalTKO.hCD46 porcine livers perfused with human blood	13
Xenotransplantation: A historical–ethical account of viewpoints	12
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He reshaped the forefront of xenotransplantation: Agustin Pasqual Dalmasso (1933–2021)	12
Complement Inhibition in Xenotransplantation–Where Should the Complement Cascade be Inhibited?	12
An ethical algorithm for xenotransplantation? Further transparency and clarity needed	12
Religion and Attitudes Toward Xenotransplantation: Results of a Nationwide Survey in the United States	11
Modified CD40L‐Activated B‐Cell Proliferation Model for Validating the Suppressive Activity of CD40‐CD154 Pathway Inhibitors	11
Xenotransplantation Literature Update December 2023–June 2024	10

Xenoreactive antibodies in α‐granules of human platelets bind pig liver endothelial cells	10
What does the PERV copy number tell us?	10
COVER IMAGE	9
Assessment of Porcine Endogenous Retrovirus Infectivity to Human Cells Using Flowcytometric Isolation After Co‐Culture	9
The case for the therapeutic use of mechanistic/mammalian target of rapamycin (mTOR) inhibitors in xenotransplantation	9
Xenotransplantation in the Age of Genome Editing: Results From the Expert Report for the Federal Ethics Committee on Nonhuman Biotechnology With a Special Focus on Animal Ethics	8
Recent progress in the pig‐to‐nonhuman primate kidney transplantation model: Report of a symposium	8
Organ xenotransplantation acceptance in veterinary students: A multicentric opinion study in Spain	8
Overcoming perioperative inflammation as a hurdle for successful preclinical orthotopic cardiac xenogeneic transplantations – particular in regard of the mandatory use of heart‐lung machines	8
Evaluation of Complement‐Dependent Cytotoxicity Assays for Gene‐Edited Pig‐to‐Human Xenotransplantation	8
Xenotransplantation of pig islet cells: Potential adverse impact of virus infections on their functionality and insulin production	8
Ethical Analysis of Voluntariness in Pig Kidney Xenotransplant First‐in‐Human Clinical Trials	8
Defect in Sensing Human Thrombin by Porcine Endothelial Protease‐Activated Receptor‐1: Molecular Incompatibility Between Porcine PAR‐1 and Human Thrombin	8
Observations on hydronephrosis after pig kidney transplantation in baboons	7
Rural Transplant Disparities and Xenotransplantation: Scaling Is Not Enough	7
Issue Information	7
Pilot Survey of Attitudes Toward Xenotransplantation Among Nursing Students in London, UK	7
Genetic diversity, growth and heart function of Auckland Island pigs, a potential source for organ xenotransplantation	7
Exploring attitudes toward xenotransplantation: A scoping review of healthcare workers, healthcare students, and kidney patients	7
Announcement	7
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Cover image	6
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Antibodies against hyaluronan oligosaccharides in xenotransplantation	6
A compositional analysis of native and decellularized porcine nasal septum cartilage	6
International Xenotransplantation Association (IXA) Position Paper on the History, Current Status, and Regulation of Xenotransplantation	6
Xenotransplantation, Ethics, and Pediatric Decedent Studies	6
Commentary on achievement of first life‐saving xenoheart transplant	6
Comparative Inhibitory Effects of Tacrolimus, Cyclosporine, and Rapamycin on Human Anti‐Pig Xenogeneic Mixed Lymphocyte Reactions	6
Asking the Right Questions: Larry Faucette's Journey Through Xenotransplant	5
Issue Information	5
The 2021 IXA Keith Reemtsma Lecture: Moving xenotransplantation to the clinic	5
Two‐day Static Cold Preservation of α1,3‐Galactosyltransferase Knockout Kidney Grafts Before Simulated Xenotransplantation	5
Large‐Scale Formation and Long‐Term Culture of Hepatocyte Organoids From Streamlined In Vivo Genome‐Edited GGTA1^−/− Pigs for Bioartificial Liver Applications	5
Historic progress in xenotransplantation with successful transplantation of genetically‐edited pig kidneys into living recipients	5
Genetic knockout of porcine GGTA1 or CMAH/GGTA1 is associated with the emergence of neo‐glycans	5
Issue Information	5
Humoral Barrier to Preclinical and Clinical Xenotransplantation	5
The impact of IdeS (imlifidase) on allo‐specific, xeno‐reactive, and protective antibodies in a sensitized rhesus macaque model	5
	4
In Memoriam – Guy Alexandre (1934–2024)	4
SARS‐CoV‐2 does not infect pigs, but this has to be verified regularly	4
Use of Brain Death Recipients in Xenotransplantation: A Double‐Edged Sword	4
Porcine Cytomegalovirus/Porcine Roseolovirus (PCMV/PRV) and Antiviral Drugs	4
Sex Differences in Maturation and Function of Neonatal Porcine Islets Upon Transplantation in Mice	4
Antibody‐mediated rejection in xenotransplantation: Can it be prevented or reversed?	4
Treatment of Presumptive Rejection After Orthotopic Pig‐to‐Baboon Cardiac Xenotransplantation	4
Xenotransplantation clinical trials: Should patients with diminished capacity be permitted to enroll?	4
Xenotransplantation of neonatal porcine bone marrow–derived mesenchymal stem cells improves diabetic wound healing by promoting angiogenesis and lymphangiogenesis	4

RETRACTION: Combinatorial Decellularization as a Better Approach to Porcine Liver Extracellular Matrix Scaffold Fabrication with Preserved Bioactivity: A Comparative Evaluation	4
In vivo induction of regulatory T cells by anti‐CD45RB antibody causes transferable tolerance to discordant human xenogenic islets	4
Long‐term efficacy and safety of porcine islet macrobeads in nonimmunosuppressed diabetic cynomolgus macaques	4
Alteration of γδ T cell subsets in non‐human primates transplanted with GGTA1 gene‐deficient porcine blood vessels	4
The International Human Xenotransplantation Inventory: Current Data and Future Directions	4
Long‐term control of diabetes by tofacitinib‐based immunosuppressive regimen after allo islet transplantation in diabetic rhesus monkeys that rejected previously transplanted porcine islets	3
How to Detect Porcine Endogenous Retrovirus (PERV) Infections in Patients After Transplantation of Pig Organs	3
Combinatorial Decellularization as a Better Approach to Porcine Liver Extracellular Matrix Scaffold Fabrication With Preserved Bioactivity: A Comparative Evaluation	3
Invited commentary: Initial reflections on the world's first clinical genetically‐engineered pig heart transplant	3
Xenotransplantation at 30 years – A personal reminiscence and some thoughts for the future	3
Pig‐to‐human kidney transplantation using brain‐dead donors as recipients: One giant leap, or only one small step for transplantkind?	3
The birth of Dolly and xenotransplantation 25 years on	3
RETRACTION: Evaluation of Complement‐Dependent Cytotoxicity Assays for Gene‐Edited Pig‐to‐Human Xenotransplantation	3
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Advances in Subclinical and Clinical Trials and Immunosuppressive Therapies in Xenotransplantation	3
Author List	3
Public Attitudes Toward Xenotransplantation in South Korea: A 2023 Survey Study	3
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Issue Information	3
	3
Patient informed consent for a clinical trial of gene‐edited pig kidney transplantation: A representative consent form	3
Genetically engineered pig kidney transplantation in a brain‐dead human subject	3
Issue Information	2
Bridging Therapies—Ex Vivo Liver Xenoperfusion and the Role of Machine Perfusion: An Update	2
In Memoriam: Sir Roy Calne, FRCS, FRS, 1930–2024	2
An IgM Cleaving Enzyme for Clearance of Anti‐Pig Xenoreactive Antibodies in a Nonhuman Primate Model	2
Development and characterization of islet‐derived mesenchymal stem cells from clinical grade neonatal porcine cryopreserved islets	2
Molecular incompatibility between pig CD200 and human CD200 receptor in in vitro xenogeneic immune responses	2
Expert opinion on the identification, risk assessment, and mitigation of microorganisms and parasites relevant to xenotransplantation products from pigs	2
Clinical cardiac xenotransplantation first in the clinical arena	2
The porcine cytomegalovirus (PCMV) will not stop xenotransplantation	2
International Xenotransplantation Association (IXA) Position Paper on Kidney Xenotransplantation	2
Cellular Landscapes of Different Gene‐Edited Pig Hearts Associated With Cardiac Xenotransplantation	2
Xenotransplantation literature update March 2023–November 2023	2
Issue Information	2
Transgenic pigs expressing near infrared fluorescent protein—A novel tool for noninvasive imaging of islet xenotransplants	2
Which Platform of SARS‐CoV‐2 Vaccines Should be Used for Xenotransplant Recipients?	2
Knock‐out of N‐glycolylneuraminic acid attenuates antibody‐mediated rejection in xenogenically perfused porcine lungs	2
Issue Information	2
Issue Information	2
Evaluation of knowledge, attitude, and awareness of liver transplant patients toward xenotransplantation	2
Anti–Non‐Gal Antibodies Against Porcine Protein Antigens as Barrier to Long‐Term Grafting of Xenografts in Humans	2
Xenogeneic Sertoli cells modulate immune response in an evolutionary distant mouse model through the production of interleukin‐10 and PD‐1 ligands expression	1
Erratum	1
Mathieu Jaboulay's (1860–1913) contribution to xenotransplantation	1
Issue Information	1
Transplantation of porcine adrenal spheroids for the treatment of adrenal insufficiency	1
Short‐term function and immune‐protection of microencapsulated adult porcine islets with alginate incorporating CXCL12 in healthy and diabetic non‐human primates without systemic immune suppression: A	1
Xenotransplantation in China: Past, Present, and Future	1
MRI monitoring of transplanted neonatal porcine islets labeled with polyvinylpyrrolidone‐coated superparamagnetic iron oxide nanoparticles in a mouse model	1
A murine groin site cardiac transplantation model—applicable tool for studying roles of peripheral lymph nodes in transplantation	1
Attitudes Toward Renal Xenotransplantation in a Muslim Country: Analysis of Specific Subgroups	1
Assessment of glomerular filtration and tubular secretion in baboons with life‐supporting pig kidney grafts	1
Large‐gap peripheral nerve repair using xenogeneic transplants in rhesus macaques	1
Barriers toward xenotransplantation in Arab World	1
Development of a panel for detection of pathogens in xenotransplantation donor pigs	1
How Much Will a Pig Organ Transplant Cost? A Preliminary Estimate of the Cost of Xenotransplantation Versus Allotransplantation in the USA	1
COVER IMAGE	1
The attitudes of religious group leaders towards xenotransplantation: A focus group study	1
Invited commentary	1
Xenotransplantation Literature Update: January–June 2025	1
Novel factors potentially initiating acute antibody‐mediated rejection in pig kidney xenografts despite an efficient immunosuppressive regimen	1
Quantitative Proteomic Analysis of Cardiac Xenograft Failure in a Pig‐to‐Non‐Human Primate Model Identifies NF‐κB as a Critical Immunomodulatory Target	1
Lessons learned from the first cardiac xenotransplant in a consciously consenting human: Psychiatric considerations and the impact of media exposure	1
Close contacts of xenograft recipients: Ethical considerations due to risk of xenozoonosis	1
The Young Investigator Committee of the International Xenotransplantation Association—Perspective of advancements in the field in 2023	1
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Issue Information	1
Porcine cytomegalovirus/porcine roseolovirus (PCMV/PRV): A threat for xenotransplantation?	1
Should you need an organ… Flemish secondary school students’ attitudes toward xenotransplantation and transgenetic organ donation	1
Non‐Classical Swine Leukocyte Antigens SLA‐6, ‐7, and ‐8, Are Xenoantigens for Some Waitlisted Patients	1
Iscalimab Combined With Transient Tesidolumab Prolongs Survival in Pig‐to‐Rhesus Monkey Renal Xenografts	1
Effects of human TFPI and CD47 expression and selectin and integrin inhibition during GalTKO.hCD46 pig lung perfusion with human blood	1
Mapping the Evolution of Solid Organ Xenotransplantation Research:A Systematic Review	1
Abstracts	1
Cover image	1
The first clinical pig heart transplant: Was IVIg or pig cytomegalovirus detrimental to the outcome?	1
Systemic inflammation in xenograft recipients (SIXR) or undetected PCMV/PRV transmission?	1
An intrinsic link to an extrinsic cause of cardiac xenograft growth after xenotransplantation	1