OOIR: Observatory of International Research

Papers

(The median citation count of Xenotransplantation is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
	108
Scientific and psychosocial ethical considerations for initial clinical trials of kidney xenotransplantation	37
Hendrik Jan (Henk) Schuurman, MSc, PhD (1950–2024): In Memoriam	36
Systemic inflammation in the xenotransplant recipient (SIXR) can occur in the absence of pCMV infection	32
Invited commentary	21
Transthoracic echocardiography is a simple tool for size matching in cardiac xenotransplantation	21
Impact of COVID‐19 Vaccination and Infection on Anti‐Triple‐Knockout (TKO) Pig Antibody Production: A Study in Patients With End‐Stage Liver Disease and Liver Transplant Recipients	20
Bioinformatic analysis as a first step to predict the compatibility of hematopoiesis and immune system genes between humans and pigs	20
Anatomical and Physiological Considerations for Pig Cardiac Xenotransplantation	19
Xenotransplantation Literature Update July–December 2024	19
First transplantation of a pig heart from a multiple gene‐modified donor, porcine cytomegalovirus/roseolovirus, and antiviral drugs	17
Anti‐pig antibodies in swine veterinarian serum: Implications for clinical xenotransplantation	16
hEPCR.hTBM.hCD47.hHO‐1 with donor clodronate and DDAVP treatment improves perfusion and function of GalTKO.hCD46 porcine livers perfused with human blood	15
Issue Information	15
Human erythrocyte fragmentation during ex‐vivo pig organ perfusion	15
ECG Features in Orthotopic Cardiac Xenotransplantation: Comparisons With Published Literature	13
Heterogenous expression of endocrine and progenitor cells within the neonatal porcine pancreatic lobes–Implications for neonatal porcine islet xenotransplantation	13
RETRACTION: An IgM Cleaving Enzyme for Clearance of Anti‐Pig Xenoreactive Antibodies in a Nonhuman Primate Model	13
He reshaped the forefront of xenotransplantation: Agustin Pasqual Dalmasso (1933–2021)	12
An ethical algorithm for xenotransplantation? Further transparency and clarity needed	12
	12
Modified CD40L‐Activated B‐Cell Proliferation Model for Validating the Suppressive Activity of CD40‐CD154 Pathway Inhibitors	11
Xenotransplantation: A historical–ethical account of viewpoints	11
Histopathology of pig kidney grafts with/without expression of the carbohydrate Neu5Gc in immunosuppressed baboons	10
Xenotransplantation Literature Update December 2023–June 2024	10

Xenoreactive antibodies in α‐granules of human platelets bind pig liver endothelial cells	10
Porcine‐derived medical therapies for SARS‐CoV‐2: Traversing Muslim bioethical concerns and assuring equity	10
The case for the therapeutic use of mechanistic/mammalian target of rapamycin (mTOR) inhibitors in xenotransplantation	9
What does the PERV copy number tell us?	9
Recent progress in the pig‐to‐nonhuman primate kidney transplantation model: Report of a symposium	8
Xenotransplantation in the Age of Genome Editing: Results From the Expert Report for the Federal Ethics Committee on Nonhuman Biotechnology With a Special Focus on Animal Ethics	8
Issue Information	8
Overcoming perioperative inflammation as a hurdle for successful preclinical orthotopic cardiac xenogeneic transplantations – particular in regard of the mandatory use of heart‐lung machines	8
Xenotransplantation of pig islet cells: Potential adverse impact of virus infections on their functionality and insulin production	8
Defect in Sensing Human Thrombin by Porcine Endothelial Protease‐Activated Receptor‐1: Molecular Incompatibility Between Porcine PAR‐1 and Human Thrombin	8
Religion and Attitudes Toward Xenotransplantation: Results of a Nationwide Survey in the United States	8
Organ xenotransplantation acceptance in veterinary students: A multicentric opinion study in Spain	8
Evaluation of Complement‐Dependent Cytotoxicity Assays for Gene‐Edited Pig‐to‐Human Xenotransplantation	8
Ethical Analysis of Voluntariness in Pig Kidney Xenotransplant First‐in‐Human Clinical Trials	8
	7
Announcement	7
A compositional analysis of native and decellularized porcine nasal septum cartilage	7
Genetic diversity, growth and heart function of Auckland Island pigs, a potential source for organ xenotransplantation	7
Cover image	7
Exploring attitudes toward xenotransplantation: A scoping review of healthcare workers, healthcare students, and kidney patients	7
Observations on hydronephrosis after pig kidney transplantation in baboons	7
Antibodies against hyaluronan oligosaccharides in xenotransplantation	7
Pilot Survey of Attitudes Toward Xenotransplantation Among Nursing Students in London, UK	6
Comparative Inhibitory Effects of Tacrolimus, Cyclosporine, and Rapamycin on Human Anti‐Pig Xenogeneic Mixed Lymphocyte Reactions	6
Historic progress in xenotransplantation with successful transplantation of genetically‐edited pig kidneys into living recipients	5
Issue Information	5
Xenotransplantation, Ethics, and Pediatric Decedent Studies	5
Issue Information	5
International Xenotransplantation Association (IXA) Position Paper on the History, Current Status, and Regulation of Xenotransplantation	5
Genetic knockout of porcine GGTA1 or CMAH/GGTA1 is associated with the emergence of neo‐glycans	5
Commentary on achievement of first life‐saving xenoheart transplant	5
Xenotransplantation of neonatal porcine bone marrow–derived mesenchymal stem cells improves diabetic wound healing by promoting angiogenesis and lymphangiogenesis	5
The impact of IdeS (imlifidase) on allo‐specific, xeno‐reactive, and protective antibodies in a sensitized rhesus macaque model	5
Large‐Scale Formation and Long‐Term Culture of Hepatocyte Organoids From Streamlined In Vivo Genome‐Edited GGTA1^−/− Pigs for Bioartificial Liver Applications	5
Asking the Right Questions: Larry Faucette's Journey Through Xenotransplant	5
Two‐day Static Cold Preservation of α1,3‐Galactosyltransferase Knockout Kidney Grafts Before Simulated Xenotransplantation	5
The 2021 IXA Keith Reemtsma Lecture: Moving xenotransplantation to the clinic	4
Antibody‐mediated rejection in xenotransplantation: Can it be prevented or reversed?	4
RETRACTION: Combinatorial Decellularization as a Better Approach to Porcine Liver Extracellular Matrix Scaffold Fabrication with Preserved Bioactivity: A Comparative Evaluation	4
SARS‐CoV‐2 does not infect pigs, but this has to be verified regularly	4
In vivo induction of regulatory T cells by anti‐CD45RB antibody causes transferable tolerance to discordant human xenogenic islets	4
	4
In Memoriam – Guy Alexandre (1934–2024)	4
The birth of Dolly and xenotransplantation 25 years on	4
Xenotransplantation clinical trials: Should patients with diminished capacity be permitted to enroll?	4
Humoral Barrier to Preclinical and Clinical Xenotransplantation	4
Sex Differences in Maturation and Function of Neonatal Porcine Islets Upon Transplantation in Mice	4
The International Human Xenotransplantation Inventory: Current Data and Future Directions	4
Long‐term efficacy and safety of porcine islet macrobeads in nonimmunosuppressed diabetic cynomolgus macaques	4
Alteration of γδ T cell subsets in non‐human primates transplanted with GGTA1 gene‐deficient porcine blood vessels	4

RETRACTION: Evaluation of Complement‐Dependent Cytotoxicity Assays for Gene‐Edited Pig‐to‐Human Xenotransplantation	3
Combinatorial Decellularization as a Better Approach to Porcine Liver Extracellular Matrix Scaffold Fabrication With Preserved Bioactivity: A Comparative Evaluation	3
Treatment of Presumptive Rejection After Orthotopic Pig‐to‐Baboon Cardiac Xenotransplantation	3
Advances in Subclinical and Clinical Trials and Immunosuppressive Therapies in Xenotransplantation	3
Genetically engineered pig kidney transplantation in a brain‐dead human subject	3
Long‐term control of diabetes by tofacitinib‐based immunosuppressive regimen after allo islet transplantation in diabetic rhesus monkeys that rejected previously transplanted porcine islets	3
	3
Use of Brain Death Recipients in Xenotransplantation: A Double‐Edged Sword	3
Xenotransplantation at 30 years – A personal reminiscence and some thoughts for the future	3
	3
Public Attitudes Toward Xenotransplantation in South Korea: A 2023 Survey Study	3
How to Detect Porcine Endogenous Retrovirus (PERV) Infections in Patients After Transplantation of Pig Organs	3
Patient informed consent for a clinical trial of gene‐edited pig kidney transplantation: A representative consent form	3
	3
Pig‐to‐human kidney transplantation using brain‐dead donors as recipients: One giant leap, or only one small step for transplantkind?	3
Invited commentary: Initial reflections on the world's first clinical genetically‐engineered pig heart transplant	3
Updateon xenotransplantation for May/June 2021	3
Xenotransplantation Literature Update: January–June 2025	2
The porcine cytomegalovirus (PCMV) will not stop xenotransplantation	2
Transgenic pigs expressing near infrared fluorescent protein—A novel tool for noninvasive imaging of islet xenotransplants	2
In Memoriam: Sir Roy Calne, FRCS, FRS, 1930–2024	2
Expert opinion on the identification, risk assessment, and mitigation of microorganisms and parasites relevant to xenotransplantation products from pigs	2
A murine groin site cardiac transplantation model—applicable tool for studying roles of peripheral lymph nodes in transplantation	2
The first clinical pig heart transplant: Was IVIg or pig cytomegalovirus detrimental to the outcome?	2
Novel factors potentially initiating acute antibody‐mediated rejection in pig kidney xenografts despite an efficient immunosuppressive regimen	2
Evaluation of knowledge, attitude, and awareness of liver transplant patients toward xenotransplantation	2
Xenotransplantation literature update March 2023–November 2023	2
Bridging Therapies—Ex Vivo Liver Xenoperfusion and the Role of Machine Perfusion: An Update	2
Issue Information	2
Knock‐out of N‐glycolylneuraminic acid attenuates antibody‐mediated rejection in xenogenically perfused porcine lungs	2
Anti–Non‐Gal Antibodies Against Porcine Protein Antigens as Barrier to Long‐Term Grafting of Xenografts in Humans	2
Issue Information	2
Xenotransplantation in China: Past, Present, and Future	2
Porcine cytomegalovirus/porcine roseolovirus (PCMV/PRV): A threat for xenotransplantation?	2
Development and characterization of islet‐derived mesenchymal stem cells from clinical grade neonatal porcine cryopreserved islets	2
An IgM Cleaving Enzyme for Clearance of Anti‐Pig Xenoreactive Antibodies in a Nonhuman Primate Model	2
Issue Information	2
Clinical cardiac xenotransplantation first in the clinical arena	2
Molecular incompatibility between pig CD200 and human CD200 receptor in in vitro xenogeneic immune responses	2
International Xenotransplantation Association (IXA) Position Paper on Kidney Xenotransplantation	2
Mathieu Jaboulay's (1860–1913) contribution to xenotransplantation	2
Quantitative Proteomic Analysis of Cardiac Xenograft Failure in a Pig‐to‐Non‐Human Primate Model Identifies NF‐κB as a Critical Immunomodulatory Target	2
Issue Information	2
Large‐gap peripheral nerve repair using xenogeneic transplants in rhesus macaques	1
Xenogeneic Sertoli cells modulate immune response in an evolutionary distant mouse model through the production of interleukin‐10 and PD‐1 ligands expression	1
An intrinsic link to an extrinsic cause of cardiac xenograft growth after xenotransplantation	1
Cover image	1
Short‐term function and immune‐protection of microencapsulated adult porcine islets with alginate incorporating CXCL12 in healthy and diabetic non‐human primates without systemic immune suppression: A	1
Non‐Classical Swine Leukocyte Antigens SLA‐6, ‐7, and ‐8, Are Xenoantigens for Some Waitlisted Patients	1
Transplantation of porcine adrenal spheroids for the treatment of adrenal insufficiency	1
Mapping the Evolution of Solid Organ Xenotransplantation Research:A Systematic Review	1
Issue Information	1
Humanized von Willebrand factor reduces platelet sequestration in ex vivo and in vivo xenotransplant models	1
Development of a panel for detection of pathogens in xenotransplantation donor pigs	1
Abstracts	1
How Much Will a Pig Organ Transplant Cost? A Preliminary Estimate of the Cost of Xenotransplantation Versus Allotransplantation in the USA	1
Iscalimab Combined With Transient Tesidolumab Prolongs Survival in Pig‐to‐Rhesus Monkey Renal Xenografts	1
The attitudes of religious group leaders towards xenotransplantation: A focus group study	1
Attitudes Toward Renal Xenotransplantation in a Muslim Country: Analysis of Specific Subgroups	1
COVER IMAGE	1
Invited commentary	1
Erratum	1
Close contacts of xenograft recipients: Ethical considerations due to risk of xenozoonosis	1
Current state of clinical trials on xenograft	1
Systemic inflammation in xenograft recipients (SIXR) or undetected PCMV/PRV transmission?	1
Should you need an organ… Flemish secondary school students’ attitudes toward xenotransplantation and transgenetic organ donation	1
	1
Assessment of glomerular filtration and tubular secretion in baboons with life‐supporting pig kidney grafts	1
Cover image	1
Effects of human TFPI and CD47 expression and selectin and integrin inhibition during GalTKO.hCD46 pig lung perfusion with human blood	1
MRI monitoring of transplanted neonatal porcine islets labeled with polyvinylpyrrolidone‐coated superparamagnetic iron oxide nanoparticles in a mouse model	1
Issue Information	1
Lessons learned from the first cardiac xenotransplant in a consciously consenting human: Psychiatric considerations and the impact of media exposure	1
The Young Investigator Committee of the International Xenotransplantation Association—Perspective of advancements in the field in 2023	1
Barriers toward xenotransplantation in Arab World	1