OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Clinical Biochemistry and Nutrition is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
TRIM62 knockdown by inhibiting the TLR4/NF-κB pathway and NLRP3 inflammasome attenuates cognitive impairment induced by diabetes in mice	41
A cross-sectional study on the relationship between nutrient/food intake and gut microbiota in frailty among older community residents: The Kyotango study	26
The accumulation of copper in the brain of Down syndrome promotes oxidative stress: possible mechanism underlying cognitive impairment	20
Characterization of the gut phageome of Japanese patients with ulcerative colitis under endoscopic remission	18
25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) induces ectopic calcification	16
The anti-inflammatory and protective role of interleukin-38 in inflammatory bowel disease	16
Development of sandwich ELISAs for detecting glucagon-like peptide-1 secretion from intestinal L-cells and their application in STC-1 cells and mice	16
The hypotaurine-taurine pathway as an antioxidative mechanism in patients with acute liver failure	13
Sirtuin 3 ameliorates inflammatory bowel disease via inhibiting intestinal inflammation and oxidative stress	13
Quenching effect of cerium oxide nanoparticles on singlet oxygen: validation of the potential for reaction with multiple reactive oxygen species	12
Reduced abundance of butyric acid-producing bacteria in the ileal mucosa-associated microbiota of ulcerative colitis patients	12
Changes in plasma-concentration ratios of branched-chain amino acids in acute and convalescent phases of bacterial pneumonia	11
Effect of folic acid supplementation on the change of plasma <i>S</i>-adenosylhomocysteine level in Chinese hypertensive patients: a randomized, double-blind, controlled clinical trial	11
Relationships between body mass index and constipation, gastroesophageal reflux disease, stool forms based on the Bristol Stool Form Scale, and education level: results from an internet survey in Japa	11
Induction of <i>MYCN</i>-amplified neuroblastoma differentiation through NMYC suppression using PPAR-γ antagonist	11
LC/MS/MS detection of uric acid oxidation metabolites to evaluate reactive oxygen and nitrogen species <i>in vivo</i> with application to pseudo-inflammation	10
Nobiletin, a polymethoxylated flavonoid from citrus, enhances IL-4 production in DO11.10 mice via antigen-presenting cells	10
8-Prenylnaringenin suppresses obesity in high-fat diet-fed C57BL/6J mice via adiponectin secretion	10
Comparison of the oxidative profiles before and after revascularization in peripheral arterial disease: a pilot study	10
Linear association between aging and decreased blood thiol antioxidant activity in patients with cataract	9
Plasma-activated medium exerts tumor-specific inhibitory effect on hepatocellular carcinoma via disruption of the salvage pathway	9
Newly developed evaluation for intestinal permeability using <i>Caenorhabditis elegans</i>: protective effects of agaro-oligosaccharides on ‍intestinal permeability	9
Association of alcohol intake and female gender with high expression of TMPRSS2 in tongue as potential risk for SARS-CoV-2 infection	9
Singlet oxygen from endoperoxide initiates an intracellular reactive oxygen species release in HaCaT keratinocytes	9
A nutritional intervention that promotes increased vegetable intake in Japanese with non-alcoholic fatty liver disease: a six-month trial	9

Association of lysophosphatidic acid molecules with liver fibrosis: different roles indicated	9
Gut dysbiosis induced by a high-salt diet aggravates atherosclerosis by increasing the absorption of saturated fatty acids in ApoE-deficient mice	8
Coenzyme Q10 levels increase with embryonic development in medaka	8
Balance of the prooxidant and antioxidant system is associated with mortality in critically ill patients	8
Fat-free oral nutritional supplements for patients after acute illness: a prospective observational study	8
Intragastric bacterial infection and endoscopic findings in <i>Helicobacter pylori</i>-negative patients	8
A mixed antioxidant supplement improves cognitive function, and coordination in aged mice	8
Treatment with broad-spectrum antibiotics upregulates Sglt1 and induces small intestinal villous hyperplasia in mice	8
Twendee X, a mixed antioxidant supplement, improves cognitive function, coordination, and neurotrophic factor expression in long-term vitamin E-deficient mice	7
GPRC5A regulates proliferation and oxidative stress by inhibiting the STAT3/Socs3/c-‍MYC pathway in hepatocellular carcinoma	7
NEK7 inhibition attenuates Aβ<sub>42</sub>-induced cognitive impairment by regulating TLR4/NF-κB and the NLRP3 inflammasome in mice	7
Stimulatory effects of collagen production induced by coenzyme Q<sub>10</sub> in cultured skin fibroblasts	7
Copper in the tumor microenvironment and tumor metastasis	7
Analysis of serum zinc level in patients with severe trauma	7
Relative low muscle mass and muscle strength is associated with the prevalence of metabolic syndrome in patients with type 2 diabetes	7
Reduced prosaposin levels in HepG2 cells with long-term coenzyme Q10 deficiency	7
Modulations of the mTORC2–GATA3 axis by ‍an ‍isorhamnetin activated endosomal–lysosomal system of the J774.1 macrophage-like cell line	6
Involvement of α-klotho in growth hormone (GH) signaling	6
HIF1α/CCL7/KIAA1199 axis mediates hypoxia-induced gastric cancer aggravation and glycolysis alteration	6
Edaravone, a scavenger for multiple reactive oxygen species, reacts with singlet oxygen to yield 2-oxo-3-(phenylhydrazono)-butanoic acid	6
Enhancement of cytotoxic effects with ALA-PDT on treatment of radioresistant cancer cells	6
Adiponectin inhibits chemokine-induced cell migration via direct interaction with platelet factor 4	6
Poricoic acid a inhibits mitochondrial dysfunction in myocardial infarction by activating SIRT3	6
Inhibition of ALA dehydratase activity in heme biosynthesis reduces cytoglobin expression which is related to the proliferation and viability of keloid fibroblasts	6
Imaging analysis for multiple paramagnetic agents using OMRI and electrophoresis	6
Reducing early pregnancy loss with vitamin D<sub>3</sub>: an analysis of serum 1,25-(OH)D<sub>3</sub> modulation and miscarriage risk	5
High poly-γ-glutamic acid-containing natto improves lipid metabolism and alters intestinal microbiota in mice fed a high-fat diet	5
Application of regulation of reactive oxygen species and lipid peroxidation to disease treatment	5
Confirmation of efficacy, elucidation of mechanism, and new search for indications of radon therapy	5
Introduction to serial reviews: Copper biology in health and disease	5
FOXM1 transcriptionally activates NEIL3 to inhibit ferroptosis in lung adenocarcinoma cells	5
Background factors of idiopathic peptic ulcers and optimal treatment methods: a multicenter retrospective Japanese study	5
Association between upper limb muscle quality and knee osteoarthritis in dynapenia: an observational cross-sectional study	5
Effects of ergothioneine on oxidative DNA damage and immune response induced by circadian rhythm disturbance in mice	5
Optimizing vitamin supplementation via reference interval update of vitamins A, E, B1, and B6 using HPLC	5
Redox state as assessed using the measurement of human non-mercaptalbumin in embryo culture media is associated with successful embryo development in human <i>in vitro</i> fertilization	5
Evaluation of malnutrition by objective nutritional indexes and predictors in hospitalized patients with COVID-19	5
Sanguinarine attenuates hypoxia/reoxygenation-triggered H9c2 cell injury through activation of the Nrf2/NLRP3 pathway	5
Effects of luseogliflozin treatment on hyperglycemia-induced muscle atrophy in rats	5
Dietary antioxidants and flavonoids intake, and their association with inflammation and oxidative stress parameters in asthmatic women: a case-control study	5
Soy isoflavone genistein attenuates the efficacy of immune checkpoint therapy in C57BL/6 mice inoculated with B16F1 melanoma and a high PD-‍L1 expression level reflects tumor resistance	5
Reduced phase angle as a potential indicator of mild cognitive impairment	4
Knockdown of LRRK2 inhibits the progression of lung cancer by regulating TLR4/NF-κB pathways and NLRP3 inflammasome	4
Improvement trend for individual health guidance intervention according to Japan clinical guidelines by public health nurses for type 2 diabetes mellitus who visited for medical checkups regularly: a	4
Relationship between serum pyridoxal 5'-‍phosphate concentration and cognitive function in older Japanese	4
A questionnaire-based survey on the etiopathogenesis of chronic constipation during a medical check-up in Japan	4
Effect of fat ingestion on postprandial oxidative status in healthy young women: a pilot study	4
Evaluation of cold atmospheric pressure plasma irradiation of water as a method of singlet oxygen generation	4
Andrographolide derivative CX-10 alleviates ulcerative colitis by modulating autophagy and cellular stress	4
Protective effects of liposomes encapsulating ferulic acid against CCl<sub>4</sub>-induced oxidative liver damage <i>in vivo</i> rat model	4

Iron as spirit of life to share under monopoly	4
Increasing trend of <i>Helicobacter pylori</i>-uninfected gastric cancer without gastric atrophy	4
The association between serum zinc level and clinical features in patients with inflammatory bowel disease	4
Effective disruption of cancer cell membranes by photodynamic therapy with cell membrane-adhesive photosensitizer	4
Dietary intervention of prebiotic partially hydrolyzed guar gum improves skin viscoelasticity, stratum corneum hydration, and ‍reduction of trans-epidermal water loss: a ‍randomized, double-blind, and	4
Crosstalk of copper and zinc in the pathogenesis of vascular dementia	4
Carotenoid transporter CD36 expression depends on hypoxia-inducible factor-1α in mouse soleus muscles	4
Acute effect of fructose, sucrose, and isomaltulose on uric acid metabolism in healthy participants	4
3-(4-Hydroxy-3-methoxyphenyl) propionic acid mitigates dexamethasone-induced muscle atrophy by attenuating Atrogin-1 and MuRF-1 expression in mouse C2C12 skeletal myotubes	4
Letter to the Editor: Increased uric acid levels following fructose consumption: a biochemical perspective	3
Recent advances in copper analyses by inorganic mass spectrometry	3
Porphyromonas gingivalis lipopolysaccharide regulates cell proliferation, apoptosis, autophagy in esophageal squamous cell carcinoma via TLR4/MYD88/JNK pathway	3
Relationship between critical care nutrition and post-intensive care syndrome in surviving ventilated patients with COVID-19: a multicenter prospective observational study	3
Comparison of mucosa-associated microbiota in Crohn’s disease patients with and without anti-tumor necrosis factor-α therapy	3
Induction of mucosal healing by intensive granulocyte/monocyte adsorptive apheresis (GMA) without use of corticosteroids in patients with ulcerative colitis: long-term remission maintenance after indu	3
Edible bird’s nest extract downregulates epidermal apoptosis and helps reduce damage by ultraviolet radiation in skin of hairless mice	3
Effects of additives on reaction of nucleosides with UV light in presence of uric acid and salicylic acid	3
β-Elemene inhibits adipogenesis in 3T3-L1 cells by regulating AMPK pathway	3
Risk factors and prediction of bleeding after gastric endoscopic submucosal dissection in patients on antithrombotic therapy: newly developed bleeding prediction application software, SAMURAI model	3
Mechanisms of action of radon therapy on cytokine levels in normal mice and rheumatoid arthritis mouse model	3
Isolation of the hemeoxygenase-1 inducer from rice-derived peptide	3
Acute effect of proprotein convertase subtilisin/kexin type 9 inhibitor on oxidized low-density lipoprotein and lipid profile in patients at cardiovascular risk	3
A randomized, double-blinded study evaluating effect of matcha green tea on human fecal microbiota	3
Can bone mass measured via bioelectrical impedance analysis be used to diagnose sarcopenia?	3
Association between dyspeptic symptoms and endoscopic findings based on the Kyoto classification of gastritis in Japanese male	3
Long-lasting renal dysfunction following tacrolimus induction therapy in ulcerative colitis patients	3
Method for detecting CoQ10 incorporation in the mitochondrial respiratory chain supercomplex	3
Influence of transarterial chemoembolization on serum opsonic activity in hepatocellular carcinoma measured by chemiluminescence	3
Quality analysis of the clinical laboratory literature and its effectiveness on clinical quality improvement: a systematic review	3
Investigation of the relationship between colonoscopy insertion difficulty factors and endoscope shape using an endoscopic position detection unit	3
Low-carbohydrate diets adversely impact the skin of a mouse model of photoaging exposed to ultraviolet B radiation	3
Vicious cycle of vitamin B<sub>1</sub> insufficiency and heart failure in cardiology outpatients	3
Retrospective investigation of mesalamine intolerance in patients with ulcerative colitis	3
Short-term intake of delta-tocotrienol on lipid profiles in healthy subjects	3
Interaction between inorganic phosphate concentration and glucose metabolism in mild refeeding syndrome model	3
Ginsenoside RK1 inhibits microglial activation and ROS production and alleviates vascular dementia in rats	3
Effect of matcha consumption on gut microbiota in healthy Japanese individuals: study protocol for a double-blind crossover interventional study	3
Unique and overlapping roles of NRF2 and NRF1 in transcriptional regulation	3
Impact of cyanidin 3-<i>O</i>-glucoside on rat micro-and systemic circulation, possibly thorough angiogenesis	2
D-Cysteine supplementation partially protects against ferroptosis induced by xCT dysfunction via increasing the availability of glutathione	2
Is nerve-directed stretching effective for improving of ankle joint flexibility and tissue stiffness in older men?	2
National trends in hospitalizations for gastrointestinal bleeding in Japan	2
Combined fructose and sucrose consumption from an early age aggravates cardiac oxidative damage and causes a dilated cardiomyopathy in ‍SHR rats	2
Eurycomanone from <i>Eurycoma longifolia</i> Jack upregulates neurotrophin-3 gene expression in ‍retinal Müller cells <i>in vitro</i>	2
SMOC2 promoted vascular smooth muscle cell proliferation, migration, and extracellular matrix degradation by activating BMP/TGF‐β1 signaling pathway	2
Sodium salicylate and 5-aminosalicylic acid synergistically inhibit the growth of human colon cancer cells and mouse intestinal polyp-derived cells	2
Dietary flaxseed oil suppresses hyperglycemia and hyperinsulinemia through increasing in α-linolenic acid content in the muscle	2
High-fat diet causes mitochondrial damage and downregulation of mitofusin-2 and optic atrophy-1 in multiple organs	2
Heat-treated and/or lysozyme-treated <i>Enterococcus faecalis</i> (FK-23) improves the progression of renal disease in a unilateral ischemia-reperfusion injury rat model	2
Levosimendan alleviates myocardial ischemia-reperfusion injury by regulating mitochondrial autophagy through cGAS-STING signaling pathway	2
5-<i>N</i>-Carboxyimino-6-aminopyrimidine-2,4(3<i>H</i>)-dione, a novel indicator for hypochlorite formation	2
Innovative novel candy made from a low-solubility amorphous material promotes saliva secretion: a randomized, double-blind, placebo-controlled crossover comparative trial	2
A newly developed solution for the preservation of short-chain fatty acids, bile acids, and microbiota in fecal specimens	2
Characterized factors of subjects who were first time diagnosed as hyperglycemia more than 126 ‍mg/dl during annual or biannual medical checkups: a case-control study in Japan	2
Acute exacerbation of idiopathic pulmonary fibrosis model by small amount of lipopolysaccharide in rats	2
Simplifying quantitative measurement of free radical species using an X-band EPR spectrometer	2
Inhibition of lincRNA-Cox2 alleviates apoptosis and inflammatory injury of lipopolysaccharide-stimulated human bronchial epithelial cells via the Nrf2/HO-1 axis	2
Response to the Letter	2
Effect of tocotrienol on the primary progression of nonalcoholic steatohepatitis in a mouse model	2
MiR-301b-3p targets and regulates EBF3 to impact the stem-like phenotype of breast cancer cells through glycolysis	2
ChREBP deficiency prevents high sucrose diet-induced obesity through reducing sucrase expression	2
Effect of omega-3 fatty acids on sleep: a systematic review and meta-analysis of randomized controlled trials	2
Miso, fermented soybean paste, suppresses high-fat/high-sucrose diet-induced muscle atrophy in mice	2
Female patients with end-stage renal failure treated by hemodialysis had a low mortality rate and small patient number compared to male patients: 5-year follow-up study in Japan	2
Aging-related dysregulation of energy metabolism and mitochondrial dynamics in ‍microglia	2
Association of urinary 8-hydroxydeoxyguanosine level with arteriosclerosis-related factors in ‍healthy, urban residents aged ≥50 years in ‍Japan	2
Microglial inflammatory reactions regulated by oxidative stress	2
Successful endoscopic hemostasis compared to transarterial embolization in patients with colonic diverticular bleeding	2
Exploratory analysis of the association between dietary niacin intakes and nonalcoholic fatty liver disease among US adults: 1999–2018 data analysis from the National Health and Nutrition Examination	2
Simple method for estimating low muscle mass in persons with bioelectrical impedance analysis measurement difficulties	2
Acetic acid enhances the effect of photodynamic therapy in gastric cancer cells via the production of reactive oxygen species	2