OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Clinical Biochemistry and Nutrition is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
The accumulation of copper in the brain of Down syndrome promotes oxidative stress: possible mechanism underlying cognitive impairment	42
TRIM62 knockdown by inhibiting the TLR4/NF-κB pathway and NLRP3 inflammasome attenuates cognitive impairment induced by diabetes in mice	30
Characterization of the gut phageome of Japanese patients with ulcerative colitis under endoscopic remission	23
A cross-sectional study on the relationship between nutrient/food intake and gut microbiota in frailty among older community residents: The Kyotango study	18
Quenching effect of cerium oxide nanoparticles on singlet oxygen: validation of the potential for reaction with multiple reactive oxygen species	16
Development of sandwich ELISAs for detecting glucagon-like peptide-1 secretion from intestinal L-cells and their application in STC-1 cells and mice	16
Sirtuin 3 ameliorates inflammatory bowel disease via inhibiting intestinal inflammation and oxidative stress	16
Reduced abundance of butyric acid-producing bacteria in the ileal mucosa-associated microbiota of ulcerative colitis patients	14
The anti-inflammatory and protective role of interleukin-38 in inflammatory bowel disease	14
The hypotaurine-taurine pathway as an antioxidative mechanism in patients with acute liver failure	13
DNA-mediated ZNF649 downregulation modulates the Hedgehog signaling pathway to reduce the sensitivity of gastric cardia cancer to 5-FU	13
25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) induces ectopic calcification	13
Plasma-activated medium exerts tumor-specific inhibitory effect on hepatocellular carcinoma via disruption of the salvage pathway	12
Effect of folic acid supplementation on the change of plasma <i>S</i>-adenosylhomocysteine level in Chinese hypertensive patients: a randomized, double-blind, controlled clinical trial	12
A nutritional intervention that promotes increased vegetable intake in Japanese with non-alcoholic fatty liver disease: a six-month trial	12
Association of alcohol intake and female gender with high expression of TMPRSS2 in tongue as potential risk for SARS-CoV-2 infection	11
8-Prenylnaringenin suppresses obesity in high-fat diet-fed C57BL/6J mice via adiponectin secretion	11
Induction of <i>MYCN</i>-amplified neuroblastoma differentiation through NMYC suppression using PPAR-γ antagonist	11
Nobiletin, a polymethoxylated flavonoid from citrus, enhances IL-4 production in DO11.10 mice via antigen-presenting cells	11
Association of lysophosphatidic acid molecules with liver fibrosis: different roles indicated	11
Changes in plasma-concentration ratios of branched-chain amino acids in acute and convalescent phases of bacterial pneumonia	11
Newly developed evaluation for intestinal permeability using <i>Caenorhabditis elegans</i>: protective effects of agaro-oligosaccharides on ‍intestinal permeability	11
Comparison of the oxidative profiles before and after revascularization in peripheral arterial disease: a pilot study	10
Relationships between body mass index and constipation, gastroesophageal reflux disease, stool forms based on the Bristol Stool Form Scale, and education level: results from an internet survey in Japa	10
Linear association between aging and decreased blood thiol antioxidant activity in patients with cataract	10

LC/MS/MS detection of uric acid oxidation metabolites to evaluate reactive oxygen and nitrogen species <i>in vivo</i> with application to pseudo-inflammation	10
Shear stress stimuli-induced erythrocytes’ mechanical damage, and its relation to erythrocytes’ membrane oxidation and cellular aging	9
Singlet oxygen from endoperoxide initiates an intracellular reactive oxygen species release in HaCaT keratinocytes	9
Balance of the prooxidant and antioxidant system is associated with mortality in critically ill patients	9
Reactive oxygen species generation by photothermal effects of adhesive near-infrared agents on the plasma membrane	9
Gut dysbiosis induced by a high-salt diet aggravates atherosclerosis by increasing the absorption of saturated fatty acids in ApoE-deficient mice	9
A mixed antioxidant supplement improves cognitive function, and coordination in aged mice	9
Intragastric bacterial infection and endoscopic findings in <i>Helicobacter pylori</i>-negative patients	9
Fat-free oral nutritional supplements for patients after acute illness: a prospective observational study	9
Treatment with broad-spectrum antibiotics upregulates Sglt1 and induces small intestinal villous hyperplasia in mice	8
Coenzyme Q10 levels increase with embryonic development in medaka	8
NEK7 inhibition attenuates Aβ<sub>42</sub>-induced cognitive impairment by regulating TLR4/NF-κB and the NLRP3 inflammasome in mice	8
Poricoic acid a inhibits mitochondrial dysfunction in myocardial infarction by activating SIRT3	8
GPRC5A regulates proliferation and oxidative stress by inhibiting the STAT3/Socs3/c-‍MYC pathway in hepatocellular carcinoma	8
Relative low muscle mass and muscle strength is associated with the prevalence of metabolic syndrome in patients with type 2 diabetes	7
Reduced prosaposin levels in HepG2 cells with long-term coenzyme Q10 deficiency	7
Edaravone, a scavenger for multiple reactive oxygen species, reacts with singlet oxygen to yield 2-oxo-3-(phenylhydrazono)-butanoic acid	7
Copper in the tumor microenvironment and tumor metastasis	7
Analysis of serum zinc level in patients with severe trauma	7
Stimulatory effects of collagen production induced by coenzyme Q<sub>10</sub> in cultured skin fibroblasts	7
Modulations of the mTORC2–GATA3 axis by ‍an ‍isorhamnetin activated endosomal–lysosomal system of the J774.1 macrophage-like cell line	7
Twendee X, a mixed antioxidant supplement, improves cognitive function, coordination, and neurotrophic factor expression in long-term vitamin E-deficient mice	7
Inhibition of ALA dehydratase activity in heme biosynthesis reduces cytoglobin expression which is related to the proliferation and viability of keloid fibroblasts	7
Involvement of α-klotho in growth hormone (GH) signaling	7
HIF1α/CCL7/KIAA1199 axis mediates hypoxia-induced gastric cancer aggravation and glycolysis alteration	6
High poly-γ-glutamic acid-containing natto improves lipid metabolism and alters intestinal microbiota in mice fed a high-fat diet	6
Association between upper limb muscle quality and knee osteoarthritis in dynapenia: an observational cross-sectional study	6
Effects of ergothioneine on oxidative DNA damage and immune response induced by circadian rhythm disturbance in mice	6
Adiponectin inhibits chemokine-induced cell migration via direct interaction with platelet factor 4	6
Background factors of idiopathic peptic ulcers and optimal treatment methods: a multicenter retrospective Japanese study	6
Imaging analysis for multiple paramagnetic agents using OMRI and electrophoresis	6
Lipoprotein(a): structural basis, bidirectional risk, and therapeutic frontiers	6
Sanguinarine attenuates hypoxia/reoxygenation-triggered H9c2 cell injury through activation of the Nrf2/NLRP3 pathway	6
Enhancement of cytotoxic effects with ALA-PDT on treatment of radioresistant cancer cells	6
Evaluation of malnutrition by objective nutritional indexes and predictors in hospitalized patients with COVID-19	6
Application of regulation of reactive oxygen species and lipid peroxidation to disease treatment	6
Reducing early pregnancy loss with vitamin D<sub>3</sub>: an analysis of serum 1,25-(OH)D<sub>3</sub> modulation and miscarriage risk	6
Introduction to serial reviews: Copper biology in health and disease	5
Dietary antioxidants and flavonoids intake, and their association with inflammation and oxidative stress parameters in asthmatic women: a case-control study	5
Dietary intervention of prebiotic partially hydrolyzed guar gum improves skin viscoelasticity, stratum corneum hydration, and ‍reduction of trans-epidermal water loss: a ‍randomized, double-blind, and	5
<i>N</i>-oxide-based and trioxolane-based fluorescent probes for monitoring labile iron and labile heme: an update	5
Andrographolide derivative CX-10 alleviates ulcerative colitis by modulating autophagy and cellular stress	5
Confirmation of efficacy, elucidation of mechanism, and new search for indications of radon therapy	5
Redox state as assessed using the measurement of human non-mercaptalbumin in embryo culture media is associated with successful embryo development in human <i>in vitro</i> fertilization	5
Soy isoflavone genistein attenuates the efficacy of immune checkpoint therapy in C57BL/6 mice inoculated with B16F1 melanoma and a high PD-‍L1 expression level reflects tumor resistance	5
Improvement trend for individual health guidance intervention according to Japan clinical guidelines by public health nurses for type 2 diabetes mellitus who visited for medical checkups regularly: a	5
FOXM1 transcriptionally activates NEIL3 to inhibit ferroptosis in lung adenocarcinoma cells	5
Optimizing vitamin supplementation via reference interval update of vitamins A, E, B1, and B6 using HPLC	5
Crosstalk of copper and zinc in the pathogenesis of vascular dementia	5
Effects of luseogliflozin treatment on hyperglycemia-induced muscle atrophy in rats	5

Relationship between serum pyridoxal 5'-‍phosphate concentration and cognitive function in older Japanese