Biological & Pharmaceutical Bulletin

Article	Citations
Characterization and Immunological Activities of Polysaccharides from <i>Polygonatum sibiricum</i>	34
Glabridin Alleviates Inflammation and Nociception in Rodents by Activating BK<sub>Ca</sub> Channels and Reducing NO Levels	33
Protective Effect of Tong-Qiao-Huo-Xue Decoction on Inflammatory Injury Caused by Intestinal Microbial Disorders in Stroke Rats	33
<i>Lycium barbarum</i> Polysaccharide Antagonizes LPS-Induced Inflammation by Altering the Glycolysis and Differentiation of Macrophages by Triggering the Degradation of PKM2	25
MiR-140-3p Ameliorates the Progression of Osteoarthritis <i>via</i> Targeting CXCR4	24
Norisoboldine Attenuates Sepsis-Induced Acute Lung Injury by Modulating Macrophage Polarization <i>via</i> PKM2/HIF-1α/PGC-1α Pathway	23
TGF-β and Cancer Immunotherapy	22
Withdrawal: Remote Reminiscence Using Immersive Virtual Reality May Be Efficacious for Reducing Anxiety in Patients with Mild Cognitive Impairment Even in COVID-19 Pandemic: A Case Report	22
Claudin-5: A Pharmacological Target to Modify the Permeability of the Blood–Brain Barrier	21
<i>Dendrobium officinale</i> Attenuates Myocardial Fibrosis <i>via</i> Inhibiting EMT Signaling Pathway in HFD/STZ-Induced Diabetic Mice	19
Application of Human Induced Pluripotent Stem Cell-Derived Intestinal Organoids as a Model of Epithelial Damage and Fibrosis in Inflammatory Bowel Disease	19
Ginsenoside Rd Inhibits Glioblastoma Cell Proliferation by Up-Regulating the Expression of miR-144-5p	19
Potential Mechanisms Underlying the Hepatic–Protective Effects of Danshensu on Iron Overload Mice	19
Risk Factors for Pseudoaldosteronism with Yokukansan Use: Analysis Using the Japanese Adverse Drug Report (JADER) Database	18
Astragaloside IV Ameliorates Cognitive Impairment and Neuroinflammation in an Oligomeric Aβ Induced Alzheimer’s Disease Mouse Model <i>via</i> Inhibition of Microglial Activation and NADPH	18
Rap1 Small GTPase Regulates Vascular Endothelial-Cadherin-Mediated Endothelial Cell–Cell Junctions and Vascular Permeability	18
Anti-metastatic Effects of Baicalein by Targeting STAT3 Activity in Breast Cancer Cells	17
Low Levels of Brain-Derived Neurotrophic Factor Trigger Self-aggregated Amyloid β-Induced Neuronal Cell Death in an Alzheimer’s Cell Model	17
Variation in Expression of Cytochrome P450 3A Isoforms and Toxicological Effects: Endo- and Exogenous Substances as Regulatory Factors and Substrates	17
Nicotine Enhances Object Recognition Memory <i>via</i> Stimulating α4β2 and α7 Nicotinic Acetylcholine Receptors in the Medial Prefrontal Cortex of Mice	16
Beta-Asarone Alleviates Myocardial Ischemia–Reperfusion Injury by Inhibiting Inflammatory Response and NLRP3 Inflammasome Mediated Pyroptosis	16
Propofol Attenuates Inflammatory Damage <i>via</i> Inhibiting NLRP1-Casp1-Casp6 Signaling in Ischemic Brain Injury	16
Association of Hypnotic Drug Use with Fall Incidents in Hospitalized Elderly Patients: A Case-Crossover Study	16
Protective Effect of Panduratin A on Cisplatin-Induced Apoptosis of Human Renal Proximal Tubular Cells and Acute Kidney Injury in Mice	15
Protective Effect of Edaravone against Cationic Lipid-Mediated Oxidative Stress and Apoptosis	15

Scutellarin Inhibits the Growth and EMT of Gastric Cancer Cells through Regulating PTEN/PI3K Pathway	14
Edaravone Ameliorates Cerebral Ischemia–Reperfusion Injury by Downregulating Ferroptosis <i>via</i> the Nrf2/FPN Pathway in Rats	14
Ampelopsin Inhibits Breast Cancer Cell Growth through Mitochondrial Apoptosis Pathway	14
Increased 20S Proteasome Expression and the Effect of Bortezomib during Cisplatin-Induced Muscle Atrophy	14
Involvement of CD73 and A2B Receptor in Radiation-Induced DNA Damage Response and Cell Migration in Human Glioblastoma A172 Cells	14
Edaravone Improves Intermittent Hypoxia-Induced Cognitive Impairment and Hippocampal Damage in Rats	13
Comparative Analysis of Anti-inflammatory Activity of the Constituents of the Rhizome of <i>Cnidium officinale</i> Using Rat Hepatocytes	13
MicroRNA-221 Upregulates the Expression of P-gp and Bcl-2 by Activating the Stat3 Pathway to Promote Doxorubicin Resistance in Osteosarcoma Cells	13
Loganin Inhibits Lipopolysaccharide-Induced Inflammation and Oxidative Response through the Activation of the Nrf2/HO-1 Signaling Pathway in RAW264.7 Macrophages	13
Therapeutic Advantage of Tyk2 Inhibition for Treating Autoimmune and Chronic Inflammatory Diseases	13
Ferulic Acid Ameliorates Isoproterenol-Induced Heart Failure by Decreasing Oxidative Stress and Inhibiting Cardiocyte Apoptosis <i>via</i> Activating Nrf2 Signaling Pathway in Rats	13
Chrono-Drug Discovery and Development Based on Circadian Rhythm of Molecular, Cellular and Organ Level	13
Machine Learning Prediction of the Three Main Input Parameters of a Simplified Physiologically Based Pharmacokinetic Model Subsequently Used to Generate Time-Dependent Plasma Concentration Data in Hum	13
Galangin Reverses Hepatic Fibrosis by Inducing HSCs Apoptosis <i>via</i> the PI3K/Akt, Bax/Bcl-2, and Wnt/β-Catenin Pathway in LX-2 Cells	13
Disulfiram Chelated with Copper Promotes Apoptosis in Osteosarcoma <i>via</i> ROS/Mitochondria Pathway	13
The Role of TNF-α in the Pathogenesis of Temporomandibular Disorders	13
The Differential Selectivity of Aryl Hydrocarbon Receptor (AHR) Agonists towards AHR-Dependent Suppression of Mammosphere Formation and Gene Transcription in Human Breast Cancer Cells	13
Neutralization of Acidic Tumor Microenvironment (TME) with Daily Oral Dosing of Sodium Potassium Citrate (K/Na Citrate) Increases Therapeutic Effect of Anti-cancer Agent in Pancreatic Cancer Xenograft	13
STAP-2 Adaptor Protein Regulates Multiple Steps of Immune and Inflammatory Responses	12
L-Theanine Attenuates Isoflurane-Induced Injury in Neural Stem Cells and Cognitive Impairment in Neonatal Mice	12
Physcion Induces Hemolysis and Premature Phosphatidylserine Externalization in Human Erythrocytes	12
Elaidic Acid Potentiates Extracellular ATP-Induced Apoptosis <i>via</i> the P2X<sub>7</sub>-ROS-ASK1-p38 Axis in Microglial Cell Lines	12
Cigarette Smoke Extract and Its Cytotoxic Factor Acrolein Inhibit Nitric Oxide Production in Human Vascular Endothelial Cells	11
Synergistic Interaction of Ochratoxin A and Acrylamide Toxins in Human Kidney and Liver Cells	11
Oridonin Suppresses Human Gastric Cancer Growth <i>in Vitro</i> and <i>in Vivo</i> <i>via</i> Inhibition of VEGF, Integrin β3, and PCNA	11
Trends of the Use of Anti-methicillin-Resistant <i>Staphylococcus aureus</i> Agents in Japan Based on Sales Data from 2006 to 2015	11
Osthole Improves Cognitive Function of Vascular Dementia Rats: Reducing Aβ Deposition <i>via</i> Inhibition NLRP3 Inflammasome	11
Activation of Host Immune Cells by Probiotic-Derived Extracellular Vesicles <i>via</i> TLR2-Mediated Signaling Pathways	11
Resolvin E1 Attenuates Chronic Pain-Induced Depression-Like Behavior in Mice: Possible Involvement of Chemerin Receptor ChemR23	11
Structural Basis for Anti-non-alcoholic Fatty Liver Disease and Diabetic Dyslipidemia Drug Saroglitazar as a PPAR α/γ Dual Agonist	11
Effects of Proton Pump Inhibitors on Survival Outcomes in Patients with Metastatic or Unresectable Urothelial Carcinoma Treated with Pembrolizumab	11
Study on the Inhibitory Activity and Possible Mechanism of Myriocin on Clinically Relevant Drug-Resistant <i>Candida albicans</i> and Its Biofilms	11
β-Aminoisobutyric Acid Suppresses Atherosclerosis in Apolipoprotein E-Knockout Mice	10
Microbial Rhodopsins as Multi-functional Photoreactive Membrane Proteins for Optogenetics	10
Androgen-Dependent Differences in the Amounts of <i>CYP</i> mRNAs in the Pig Kidney	10
Russelioside A, a Pregnane Glycoside from <i>Caralluma tuberculate</i>, Inhibits Cell-Intrinsic NF-κB Activity and Metastatic Ability of Breast Cancer Cells	10
Betanin Prevents Experimental Abdominal Aortic Aneurysm Progression by Modulating the TLR4/NF-κB and Nrf2/HO-1 Pathways	10
Identification and Validation of Combination Plasma Biomarker of Afamin, Fibronectin and Sex Hormone-Binding Globulin to Predict Pre-eclampsia	10
Pegfilgrastim (PEG-G-CSF) Induces Anti-polyethylene Glycol (PEG) IgM <i>via</i> a T Cell-Dependent Mechanism	10
Induction of PD-L1 by Nitric Oxide <i>via</i> JNK Activation in A172 Glioblastoma Cells	10
Protective Effect of Fuzi Lizhong Decoction against Non-alcoholic Fatty Liver Disease <i>via</i> Anti-inflammatory Response through Regulating p53 and PPARG Signaling	10
Detection of Abacavir-Induced Structural Alterations in Human Leukocyte Antigen-B*57 : 01 Using Phage Display	10
Impact of Gut Microbiota on the Pharmacokinetics of Glycyrrhizic Acid in Yokukansan, a Kampo Medicine	10
Improved Detection Sensitivity of an Antigen Test for SARS-CoV-2 Nucleocapsid Proteins with Thio-NAD Cycling	10
Exopolysaccharide Produced by Plant-Derived <i>Lactobacillus plantarum</i> SN35N Exhibits Antiviral Activity	10
Epigallocatechin-3-Gallate Suppresses the Expression of TNF-α-Induced MMP-1 <i>via</i> MAPK/ERK Signaling Pathways in Human Dermal Fibroblasts	10
Increasing Tumor Extracellular pH by an Oral Alkalinizing Agent Improves Antitumor Responses of Anti-PD-1 Antibody: Implication of Relationships between Serum Bicarbonate Concentrations, Urinary pH, a	10
Germacrone Reduces Cisplatin-Induced Toxicity of Renal Proximal Tubular Cells <i>via</i> Inhibition of Organic Cation Transporter	10
Renal Reabsorptive Transport of Uric Acid Precursor Xanthine by URAT1 and GLUT9	10
Development of a Diagnostic Screening Strategy for Niemann–Pick Diseases Based on Simultaneous Liquid Chromatography-Tandem Mass Spectrometry Analyses of <i>N</i>-Palmitoyl-<i>O</	10

Rosmarinic Acid Protects Mice from Concanavalin A-Induced Hepatic Injury through AMPK Signaling	10
Hydrogen Sulfide Improves Functional Recovery in Rat Traumatic Spinal Cord Injury Model by Inducing Nuclear Translocation of NF-E2-Related Factor 2	10
<i>Ziyuglycoside II</i> Inhibits Rotavirus Induced Diarrhea Possibly <i>via</i> TLR4/NF-κB Pathways	9
Pharmacology of Antagonism of GPCR	9
Inhibitory effect of Astragalus Polysaccharide combined with cisplatin on cell cycle and migration of nasopharyngeal carcinoma cell lines	9
Glucosyl Hesperidin Has an Anti-diabetic Effect in High-Fat Diet-Induced Obese Mice	9
Sinomenine Can Inhibit the Growth and Invasion Ability of Retinoblastoma Cell through Regulating PI3K/AKT Signaling Pathway	9
Development, characterization and potential applications of a multicellular spheroidal human blood-brain barrier model integrating three conditionally immortalized cell lines	9
Puerarin Protects against Myocardial Ischemia/Reperfusion Injury by Inhibiting Ferroptosis	9
Tapentadol in Cancer Patients with Neuropathic Pain: A Comparison of Methadone, Oxycodone, Fentanyl, and Hydromorphone	9
Enhanced Vascular Permeability by Microbubbles and Ultrasound in Drug Delivery	9
8-HEPE-Concentrated Materials from Pacific Krill Improve Plasma Cholesterol Levels and Hepatic Steatosis in High Cholesterol Diet-Fed Low-Density Lipoprotein (LDL) Receptor-Deficient Mice	9
Functional Interaction between Cytochrome P450 and UDP-Glucuronosyltransferase on the Endoplasmic Reticulum Membrane: One of Post-translational Factors Which Possibly Contributes to Their Inter-Indivi	9
Pannexin 1 Mediates Gastric Cancer Cell Epithelial–Mesenchymal Transition <i>via</i> Aquaporin 5	9
Morphine Stimulates Migration and Growth and Alleviates the Effects of Chemo Drugs <i>via</i> AMPK-Dependent Induction of Epithelial–Mesenchymal Transition in Esophageal Carcinoma Cells	9
Simultaneous Screening of SARS-CoV-2 Omicron and Delta Variants Using High-Resolution Melting Analysis	9
Cathepsin G-Induced Insulin-Like Growth Factor (IGF) Elevation in MCF-7 Medium Is Caused by Proteolysis of IGF Binding Protein (IGFBP)-2 but Not of IGF-1	8
Dexmedetomidine relieved neuropathic pain and inflammation response induced by CCI through HMGB1/TLR4/NF-κB signal pathway	8
Salidroside Induces Apoptosis in Human Gastric Cancer Cells <i>via</i> the Downregulation of ENO1/PKM2/GLUT1 Expression	8
Dehydrocholic Acid Ameliorates Sodium Taurocholate-Induced Acute Biliary Pancreatitis in Mice	8
Pharmacokinetics, Tissue Distribution, and Druggability Prediction of the Natural Anticancer Active Compound Cytisine <i>N</i>-Isoflavones Combined with Computer Simulation	8
Polyherbal Formulation Enhancing Cerebral Slow Waves in Sleeping Rats	8
<i>trans</i>-Fatty Acids as an Enhancer of Inflammation and Cell Death: Molecular Basis for Their Pathological Actions	8
Gomisin N Exerts Anti-liver Cancer Effects and Regulates PI3K–Akt and mTOR–ULK1 Pathways <i>in Vitro</i>	8
Trends Associated with Hemorrhoids in Japan: Data Mining of Medical Information Datasets and the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB) Open Data Japa	8
Development of an SS-Cleavable pH-Activated Lipid-Like Material (ssPalm) as a Nucleic Acid Delivery Device	8
The Japanese Herbal (Kampo) Medicine Hochuekkito Attenuates Lung Inflammation in Lung Emphysema	8
Safety of Remdesivir in 20 Children with COVID-19—Case Series—	8
Linarin Protects the Kidney against Ischemia/Reperfusion Injury <i>via</i> the Inhibition of Bioactive ETS2/IL-12	8
Mitochondrial Uncouplers Confer Protection by Activating AMP-Activated Protein Kinase to Inhibit Neuroinflammation Following Intracerebral Hemorrhage	8
Effects of Cholesterol on Membrane Stability of Human Erythrocytes	8
Polyphyllin E Inhibits Proliferation, Migration and Invasion of Ovarian Cancer Cells by Down-Regulating the AKT/NF-κB Pathway	8
Artesunate Provides Neuroprotection against Cerebral Ischemia–Reperfusion Injury <i>via</i> the TLR-4/NF-κB Pathway in Rats	8
The Light-Inducible Genes <i>Per2</i>, <i>Cry1a</i>, and <i>Cry2a</i> Regulate Oxidative Status in Zebrafish	8
A Lipid-Based Nanocarrier Containing Active Vitamin D<sub>3</sub> Ameliorates NASH in Mice <i>via</i> Direct and Intestine-Mediated Effects on Liver Inflammation	8
Trends of Antifungal Use Based on Sales Data in Japan from 2006 to 2015	8
Andrographolide/Phospholipid/Cyclodextrin Complex-Loaded Nanoemulsion: Preparation, Optimization, <i>in Vitro</i> and <i>in Vivo</i> Evaluation	8
Oroxylin A Exerts Its Antitumor Effects in Human Gallbladder Cancer <i>via</i> Inhibition of the PTEN/PI3K/AKT Signaling Pathway	8
Accumulation of Toxic Advanced Glycation End-Products Induces Cytotoxicity and Inflammation in Hepatocyte-Like Cells Differentiated from Human Induced Pluripotent Stem Cells	8
Berberine Encapsulated in Exosomes Derived from Platelet-Rich Plasma Promotes Chondrogenic Differentiation of the Bone Marrow Mesenchymal Stem Cells <i>via</i> the Wnt/β-Catenin Pathway	8
Amelioration of the Lipogenesis, Oxidative Stress and Apoptosis of Hepatocytes by a Novel Proteoglycan from <i>Ganoderma lucidum</i>	7
Synergistic Antinociceptive Activity of Tramadol/Acetaminophen Combination Mediated by μ-Opioid Receptors	7
Safety and Biocompatibility of Mupirocin Nanoparticle-Loaded Hydrogel on Burn Wound in Rat Model	7
Detection Method of Falsified Medicines by Using a Low-Cost Raman Scattering Spectrometer Combined with Soft Independent Modeling of Class Analogy and Partial Least Squares Discriminant Analysis	7
Total Saponins from <i>Paris forrestii</i> Reverse Multidrug Resistance of MCF-7/ADM Cells by Suppression of P-gp <i>via</i> ERK Signaling Pathway	7
Pharmacological Inhibition of Transient Receptor Potential Vanilloid 4 Reduces Vasogenic Edema after Traumatic Brain Injury in Mice	7
Investigating DNA Methylation of <i>SHATI/NAT8L</i> Promoter Sites in Blood of Unmedicated Patients with Major Depressive Disorder	7
Pharmacological Inhibition of MCT4 Reduces 4-Hydroxytamoxifen Sensitivity by Increasing HIF-1α Protein Expression in ER-Positive MCF-7 Breast Cancer Cells	7
Insights into Dynamic Mechanism of Ligand Binding to Peroxisome Proliferator-Activated Receptor γ toward Potential Pharmacological Applications	7
Reciprocal Relationship between Ca<sup>2+</sup> Signaling and Ca<sup>2+</sup>-Gated Ion Channels as a Potential Target for Drug Discovery	7
Licochalcone B Induced Apoptosis and Autophagy in Osteosarcoma Tumor Cells <i>via</i> the Inactivation of PI3K/AKT/mTOR Pathway	7
Comparison of the Safety and Effectiveness of Four Direct Oral Anticoagulants in Japanese Patients with Nonvalvular Atrial Fibrillation Using Real-World Data	7
The Physiological and Pathophysiological Role of IL-6/STAT3-Mediated Signal Transduction and STAT3 Binding Partners in Therapeutic Applications	7
Evaluation of Proteinuria Using Urine Protein : Creatine Ratio in Treatment with Molecular Targeted Agents for Advanced Renal Cell Carcinoma	7
High-Dose Vitamin C Exerts Its Anti-cancer Effects in a Xenograft Model of Colon Cancer by Suppressing Angiogenesis	7
Effect of <i>N</i>-Acetyl Cysteine on Renal Interstitial Fibrosis in Mice	7
Sanguinarine Rapidly Relaxes Rat Airway Smooth Muscle Cells Dependent on TAS2R Signaling	7
Curculigoside Represses the Proliferation and Metastasis of Osteosarcoma <i>via</i> the JAK/STAT and NF-κB Signaling Pathways	7
Use of Iontophoresis Technology for Transdermal Delivery of a Minimal mRNA Vaccine as a Potential Melanoma Therapeutic	7
Renoprotective Effect of Oridonin in a Mouse Model of Acute Kidney Injury <i>via</i> Suppression of Macrophage Involved Inflammation	7
Influence of Crocetin, a Natural Carotenoid Dicarboxylic Acid in Saffron, on L-Type Ca<sup>2+</sup> Current, Intracellular Ca<sup>2+</sup> Handling and Contraction of Isolated	7
Evaluation of Agonistic Activity of Fluorinated and Nonfluorinated Fentanyl Analogs on μ-Opioid Receptor Using a Cell-Based Assay System	7
Prescription of Colchicine with Other Dangerous Concomitant Medications: A Nation-Wide Survey Using the Japanese Claims Database	7
Emodin Suppresses the Migration and Invasion of Melanoma Cells	7
Synthesis and Biological Evaluation of Salicylic Acid Analogues of Celecoxib as a New Class of Selective Cyclooxygenase-1 Inhibitor	7
Methylglyoxal-Derived Advanced Glycation End Products (AGE4) Promote Cell Proliferation and Survival in Renal Cell Carcinoma Cells through the RAGE/Akt/ERK Signaling Pathways	7
3′,4′,7-Trihydroxyflavone Downregulates NO Production in LPS- or IFN-γ-Activated MG6 Microglial Cells by Attenuating the JNK–STAT1 Pathway	7
Emodin Inhibits Resistance to Imatinib by Downregulation of Bcr-Abl and STAT5 and Allosteric Inhibition in Chronic Myeloid Leukemia Cells	7
V-ATPase a3 Subunit in Secretory Lysosome Trafficking in Osteoclasts	7
Effect of Ginsenoside Rb2 on a Myocardial Cell Model of Coronary Heart Disease through Nrf2/HO-1 Signaling Pathway	7
Role of Mitochondrial Dysfunction in the Pathogenesis of Cisplatin-Induced Myotube Atrophy	7
Macrophage Response Driven by Extracellular ATP	7
High-Dose Vitamin C Administration Inhibits the Invasion and Proliferation of Melanoma Cells in Mice Ovary	7
Expression, Purification and Characterization of CAR/NCOA-1 Tethered Protein in <i>E. coli</i> Using Maltose-Binding Protein Fusion Tag and Gelatinized Corn Starch	7
Lag Time for New Innovative, First-in-Class, Drug Approval in Japan	7
Signal Detection of Potential Hepatotoxic Drugs: Case-Control Study Using Both a Spontaneous Reporting System and Electronic Medical Records	7
Pharmaceutical Care Contributes to the Advanced Management of Patients Receiving Immune Checkpoint Inhibitors	7
Dexmedetomidine Reduces the Lidocaine-Induced Neurotoxicity by Inhibiting Inflammasome Activation and Reducing Pyroptosis in Rats	7
Sex, Organ, and Breed Differences in the mRNA Expression of Drug Transporters in the Liver and Kidney of Pigs	6
Predicting Method for the Human Plasma Concentration–Time Profile of a Monoclonal Antibody from the Half-life of Non-human Primates	6

Infliximab Treatment Persistence among Japanese Patients with Chronic Inflammatory Diseases: A Retrospective Japanese Claims Data Study	6
Strengthening the Competitiveness of Japan’s Pharmaceutical Industry: Analysis of Country Differences in the Origin of New Drugs and Japan’s Highly Productive Firm	6
PTP1B Inhibitory and Anti-inflammatory Properties of Constituents from <i>Eclipta prostrata</i> L.	6
Different Renal Chronotoxicity of Bromobenzene and Its Intermediate Metabolites in Mice	6
Anti-allergic Inflammatory Components from the Leaves of <i>Piper crocatum</i> Ruiz & Pav.	6
Latifolin Inhibits Oxidative Stress-Induced Senescence <i>via</i> Upregulation of SIRT1 in Human Dermal Fibroblasts	6
Cancer Cachexia May Hinder Pain Control When Using Fentanyl Patch	6
<i>Opuntia ficus</i> <i>indica</i> Fruits Ameliorate Cisplatin-Induced Nephrotoxicity in Mice	6
Acute Ramelteon Treatment Maintains the Cardiac Rhythms of Rats during Non-REM Sleep	6
Gambogenic Acid Inhibits Basal Autophagy of Drug-Resistant Hepatoma Cells and Improves Its Sensitivity to Adriamycin	6
<i>In Vitro</i> and <i>in Vivo</i> Comparative Study of Oral Nanoparticles and Gut Iontophoresis as Oral Delivery Systems for Insulin	6
A Radiolabeled Self-assembled Nanoparticle Probe for Diagnosis of Lung-Metastatic Melanoma	6
Yi-Zhi-Fang-Dai Formula Exerts a Protective Effect on the Injury of Tight Junction Scaffold Proteins <i>in Vitro</i> and <i>in Vivo</i> by Mediating Autophagy through Regulatio	6
Osteoclast Differentiation Is Suppressed by Increased <i>O</i>-GlcNAcylation Due to Thiamet G Treatment	6
The Role of Potassium Channels in Chronic Stress-Induced Brain Injury	6
Effects of Bepridil and Pimozide, Existing Medicines Capable of Blocking T-Type Ca<sup>2+</sup> Channels, on Visceral Pain in Mice	6
LncRNA Snhg5 Attenuates Status Epilepticus Induced Inflammation through Regulating NF-κΒ Signaling Pathway	6
Picropodophyllin Inhibits the Proliferation of Human Prostate Cancer DU145 and LNCaP Cells <i>via</i> ROS Production and PI3K/AKT Pathway Inhibition	6
<i>Acanthopanax senticosus</i> Root Extract Exerts Dual Action on Mouse Ileal Smooth Muscle Function, Leading to Modulation of Gastrointestinal Motility	6
Pyoluteorin Induces Apoptosis and Autophagy in NSCLC Cells	6
Establishment of Three Types of Immortalized Human Skin Stem Cell Lines Derived from the Single Donor	6
Topical Xerostomia Treatment with Hyaluronate Sheets Containing Pilocarpine	6
PI3K/AKT1 Signaling Pathway Mediates Sinomenine-Induced Hepatocellular Carcinoma Cells Apoptosis: An <i>in Vitro</i> and <i>in Vivo</i> Study	6
Effect of Cinacalcet on the Redox Status of Albumin in Secondary Hyperparathyroidism Patients Receiving Hemodialysis	6
Angiotensin (1–7) Attenuates the Nociceptive Behavior Induced by Substance P and NMDA <i>via</i> Spinal MAS1	6
Comparison of the Stimulatory and Inhibitory Effects of Steroid Hormones and α-Naphthoflavone on Steroid Hormone Hydroxylation Catalyzed by Human Cytochrome P450 3A Subfamilies	6
The Effect of Thymoquinone on the Characteristics of the Brain Extracellular Space in Transient Middle Cerebral Artery Occlusion Rats	6
Deletion of TRPC3 or TRPC6 Fails to Attenuate the Formation of Inflammation and Fibrosis in Non-alcoholic Steatohepatitis	6
Inhibitory Effect of the Traditional Chinese Medicine <i>Ephedra sinica granules</i> on <i>Streptococcus pneumoniae</i> Pneumolysin	6
Effects of Oxidation of Human Serum Albumin on the Binding of Aripiprazole	6
Establishment of a Simple Method for Inducing Neuronal Differentiation of P19 EC Cells without Embryoid Body Formation and Analysis of the Role of Histone Deacetylase 8 Activity in This Differentiatio	6
Involvement of TRPM8 Channel in Radiation-Induced DNA Damage Repair Mechanism Contributing to Radioresistance of B16 Melanoma	6
Low Expression of Rasal2 Promotes Non-small Cell Lung Cancer Metastasis through Ras/ERK Pathway	6
Three-Dimensional Culture of Umbilical Cord Mesenchymal Stem Cells Effectively Promotes Platelet Recovery in Immune Thrombocytopenia	6
Nicotine Enhances Firing Activity of Layer 5 Pyramidal Neurons in the Medial Prefrontal Cortex through Inhibition of Kv7 Channels	6
Oxidative Formation of Methylglyoxal in Glycerol Preparations during Storage	6
Estrogen Receptor β as a Possible Double-Edged Sword Molecule in Breast Cancer: A Mechanism of Alteration of Its Role by Exposure to Endocrine-Disrupting Chemicals	6
Quantitative Proteomics-Based Blood–Brain Barrier Study	6
NSC23766 and Ehop016 Suppress Herpes Simplex Virus-1 Replication by Inhibiting Rac1 Activity	6
Inhibition of Stearoyl-CoA Desaturase 1 Potentiates Anti-tumor Activity of Amodiaquine in Non-small Cell Lung Cancer	6
One-Pot Process for the Production of Ginsenoside Rd by Coupling Enzyme-Assisted Extraction with Selective Enzymolysis	6
Target Therapeutic Ranges of Anti-MRSA Drugs, Linezolid, Tedizolid and Daptomycin, and the Necessity of TDM	6
Candidone Inhibits Migration and Invasion, and Induces Apoptosis in HepG2 Cells	5
Role of Epoxyeicosatrienoic Acids in Acetylcholine-Induced Dilation of Rat Retinal Arterioles <i>in Vivo</i>	5
Hesperidin Inhibits UVB-Induced VEGF Production and Angiogenesis <i>via</i> the Inhibition of PI3K/Akt Pathway in HR-1 Hairless Mice	5
Protonation State of a Histidine Residue in Human Oligopeptide Transporter 1 (hPEPT1) Regulates hPEPT1-Mediated Efflux Activity	5
LRRK2 Inhibition Ameliorates Dexamethasone-Induced Glucose Intolerance <i>via</i> Prevents Impairment in GLUT4 Membrane Translocation in Adipocytes	5
Evaluation of Daptomycin-Induced Cellular Membrane Injury in Skeletal Muscle	5
Calycosin may Alleviate Ang II-Induced Pro-proliferative Effects on Glomerular Mesangial Cells <i>via</i> Partially Inhibiting Autophagy and ERK Signaling Pathway	5
Topical Application of BMS-509744, a Selective Inhibitor of Interleukin-2-Inducible T Cell Kinase, Ameliorates Imiquimod-Induced Skin Inflammation in Mice	5
Down-Regulation of Ubiquitin-Specific Peptidase 9X Inhibited Proliferation, Migration and Invasion of Osteosarcoma <i>via</i> ERK1/2 and PI3K/Akt Signaling Pathways	5
Hyodeoxycholic Acid (HDCA) Prevents Development of Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice: Possible Role of Synergism between DSS and HDCA in Increasing Fecal Bile Acid Levels	5
The Ethyl Acetate Subfraction of <i>Polygonum cuspidatum</i> Root Containing Emodin Affect EBV Gene Expression and Induce EBV-Positive Cells Apoptosis	5
Hsa_circ_0002060 Knockdown Ameliorates Osteoporosis by Targeting MiR-198-5p	5
Involvement of the Hippocampal Alpha2A-Adrenoceptors in Anxiety-Related Behaviors Elicited by Intermittent REM Sleep Deprivation-Induced Stress in Mice	5
Increased Vancomycin Clearance in Patients with Solid Malignancies	5
Antidepressant Effect of Intracerebroventricularly Administered Deltorphin Analogs in the Mouse Tail Suspension Test	5
Cytotoxic Effects of Water-Soluble Extracts of Coarse and Fine Atmospheric Particulate Matter on Mast Cell Lines	5
Indomethacin, a Non-steroidal Anti-inflammatory Drug, Induces Skin Dryness <i>via</i> PPARγ in Mice	5
Temozolomide Induces Endocytosis of EGFRvIII <i>via</i> p38-Mediated Non-canonical Phosphorylation in Glioblastoma Cells	5
Suppression of Hepatic Stellate Cell Death by Toxic Advanced Glycation End-Products	5
Chemical Activation of Piezo1 Alters Biomechanical Behaviors toward Relaxation of Cultured Airway Smooth Muscle Cells	5
Pharmacokinetic and Adsorptive Analyses of Administration of Oral Voriconazole Suspension <i>via</i> Enteral Feeding Tube in Intensive Care Unit Patients	5
Targeting the Oxytocin System to Ameliorate Early Life Depressive-Like Behaviors in Maternally-Separated Rats	5
Machine Learning-Based Model for Estimating Vancomycin Maintenance Dose to Target the Area under the Concentration Curve of 400–600 mg·h/L in Japanese Patients	5
Cytoprotective Effects Evaluation of a Novel Danshensu Derivative DEX-018 against Oxidative Stress Injury in HUVECs	5
4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP) Targets Estrogen Receptor β, to Evoke the Resistance of Human Breast Cancer MCF-7 Cells to G-1, an Agonist for G Protein-Coupled Estrogen Receptor 1	5
Disproportionality Analysis of Safety Signals for a Wide Variety of Opioid-Related Adverse Events in Elderly Patients Using the Japanese Adverse Drug Event Report (JADER) Database	5
Functional Alterations of Multidrug Resistance-Associated Proteins 2 and 5, and Breast Cancer Resistance Protein upon Snail-Induced Epithelial–Mesenchymal Transition in HCC827 Cells	5
Possible Therapeutic Applications of Targeting STAP Proteins in Cancer	5
Effects of Uremic Toxins on the Binding of Aripiprazole to Human Serum Albumin	5
Development of a Competitive Enzyme-Linked Immunosorbent Assay for the Determination of Sunitinib Unaffected by Light-Induced Isomerization	5
Effective Anticancer Therapy by Combination of Nanoparticles Encapsulating Chemotherapeutic Agents and Weak Electric Current	5
Overexpressed Hsa_circ_0001326 Contributes to the Decreased Cell Viability in SWAN71 Cells by Regulating MiR-186-5p/p27 Kip1 Axis	5
Vitexin Attenuates Non-alcoholic Fatty Liver Disease Lipid Accumulation in High Fat-Diet Fed Mice by Activating Autophagy and Reducing Endoplasmic Reticulum Stress in Liver	5
Cold-Restraint Stress-Induced Ultrasonic Vocalization as a Novel Tool to Measure Anxiety in Mice	5
Crystal Structures of the Human Peroxisome Proliferator-Activated Receptor (PPAR)α Ligand-Binding Domain in Complexes with a Series of Phenylpropanoic Acid Derivatives Generated by a Ligand-Exchange S	5
Octa-arginine and Octa-lysine Promote Cell Adhesion through Heparan Sulfate Proteoglycans and Integrins	5
Silver Nanoparticles Induce DNA Hypomethylation through Proteasome-Mediated Degradation of DNA Methyltransferase 1	5
A Novel Myricetin Derivative with Anti-cancer Properties Induces Cell Cycle Arrest and Apoptosis in A549 Cells	5
Targeting Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) for the Treatment or Prevention of Alcoholic Liver Disease	5
Mechanotransduction-Targeting Drugs Attenuate Stiffness-Induced Hepatic Stellate Cell Activation <i>in Vitro</i>	5
Pharmaceutical Technology Innovation Strategy Based on the Function of Blood Transport Proteins as DDS Carriers for the Treatment of Intractable Disorders and Cancer	5
The Many Roles of Lysophospholipid Mediators and Japanese Contributions to This Field	5
Juzentaihoto Suppresses Muscle Atrophy and Decreased Motor Function in SAMP8 Mice	5
Inflammation-Induced Attenuation of Prostaglandin D<sub>2</sub> Elimination across Rat Blood–Brain Barrier: Involvement of the Downregulation of Organic Anion Transporter 3 and Multidrug R	5
Isosteviol Sodium Attenuates High Fat/High Cholesterol-Induced Kidney Dysfunction by Inhibiting Inflammation, Oxidative Stress and Apoptosis	5
Disulfiram Synergizes with SRC Inhibitors to Suppress the Growth of Pancreatic Ductal Adenocarcinoma Cells <i>in Vitro</i> and <i>in Vivo</i>	4
Vitamin K2 Suppresses Proliferation and Inflammatory Cytokine Production in Mitogen-Activated Lymphocytes of Atopic Dermatitis Patients through the Inhibition of Mitogen-Activated Protein Kinases	4
A Methoxyflavanone from <i>Perilla frutescens</i> Induces Cellular Senescence in A549 Human Lung Adenocarcinoma Cells but Not in Normal Human Bronchial Epithelial Cells	4
The Carboxyl-Terminal Penta-Peptide Repeats of Major Royal Jelly Protein 3 Enhance Cell Proliferation	4
Anti-inflammatory Effects of Sanhuang-Siwu-Tang in Lipopolysaccharide-Stimulated RAW264.7 Macrophages and BV2 Microglial Cells	4
Current Understanding of the Intestinal Absorption of Nucleobases and Analogs	4
Proton Pumping ATPases: Rotational Catalysis, Physiological Roles in Oral Pathogenic Bacteria, and Inhibitors	4
KB-R7943 Inhibits the Mitochondrial Ca<sup>2+</sup> Uniporter but Not Na<sup>+</sup>–Ca<sup>2+</sup> Exchanger in Cardiomyocyte-Derived H9c2 Cells	4