Inflammopharmacology

Article	Citations
The Role and Therapeutic Potential of NF-kappa-B Pathway in Severe COVID-19 Patients	204
COVID-19 and therapy with essential oils having antiviral, anti-inflammatory, and immunomodulatory properties	141
Recent advances in molecular pathways and therapeutic implications targeting neuroinflammation for Alzheimer’s disease	113
Role of vitamins and minerals as immunity boosters in COVID-19	98
COVID-19 vaccines and decreased transmission of SARS-CoV-2	95
The anti-inflammatory role of SSRI and SNRI in the treatment of depression: a review of human and rodent research studies	56
Real-world effectiveness of BNT162b2 mRNA vaccine: a meta-analysis of large observational studies	53
COVID-19 and the role of cytokines in this disease	48
High-mobility group box 1 (HMGB1) in COVID-19: extrapolation of dangerous liaisons	48
Exosome engineering in cell therapy and drug delivery	46
Alzheimer’s disease: natural products as inhibitors of neuroinflammation	46
Baicalein exerts neuroprotective effect against ischaemic/reperfusion injury via alteration of NF-kB and LOX and AMPK/Nrf2 pathway	44
Pathogenesis and management of traumatic brain injury (TBI): role of neuroinflammation and anti-inflammatory drugs	43
Health benefits of cyanidin-3-glucoside as a potent modulator of Nrf2-mediated oxidative stress	43
Brief review of the mRNA vaccines COVID-19	42
Empagliflozin suppresses inflammation and protects against acute septic renal injury	41
Neuropathophysiology of coronavirus disease 2019: neuroinflammation and blood brain barrier disruption are critical pathophysiological processes that contribute to the clinical symptoms of SARS-CoV-2	38
COVID-19 and corticosteroids: a narrative review	37
Paeoniflorin attenuates chronic constriction injury-induced neuropathic pain by suppressing spinal NLRP3 inflammasome activation	34
TissueGene-C promotes an anti-inflammatory micro-environment in a rat monoiodoacetate model of osteoarthritis via polarization of M2 macrophages leading to pain relief and structural improvement	33
SIRT1 pathway in Parkinson’s disease: a faraway snapshot but so close	32
A narrative review of the potential pharmacological influence and safety of ibuprofen on coronavirus disease 19 (COVID-19), ACE2, and the immune system: a dichotomy of expectation and reality	32
Neuroprotective effect of liraglutide in an experimental mouse model of multiple sclerosis: role of AMPK/SIRT1 signaling and NLRP3 inflammasome	32
Dapagliflozin, an SGLT2 inhibitor, ameliorates acetic acid-induced colitis in rats by targeting NFκB/AMPK/NLRP3 axis	32
Novel complementary coloprotective effects of metformin and MCC950 by modulating HSP90/NLRP3 interaction and inducing autophagy in rats	31

A retrospective study of the efficacy of JAK inhibitors or abatacept on rheumatoid arthritis-interstitial lung disease	31
Pirfenidone and post-Covid-19 pulmonary fibrosis: invoked again for realistic goals	30
The role of AMPK-dependent pathways in cellular and molecular mechanisms of metformin: a new perspective for treatment and prevention of diseases	30
A raising dawn of pentoxifylline in management of inflammatory disorders in Covid-19	29
Therapeutic benefits of flavonoids against neuroinflammation: a systematic review	29
Natural compounds as safe therapeutic options for ulcerative colitis	29
Standardised pomegranate peel extract lavage prevents postoperative peritoneal adhesion by regulating TGF-β and VEGF levels	28
Paeoniflorin ameliorates ulcerative colitis by modulating the dendritic cell-mediated TH17/Treg balance	27
Melatonin and multiple sclerosis: antioxidant, anti-inflammatory and immunomodulator mechanism of action	26
Anti-inflammatory effect of stevioside abates Freund’s complete adjuvant (FCA)-induced adjuvant arthritis in rats	26
Methanolic extract of Ephedra ciliata promotes wound healing and arrests inflammatory cascade in vivo through downregulation of TNF-α	26
Neuroprotective potential of isothiocyanates in an in vitro model of neuroinflammation	24
Boswellic acids/Boswellia serrata extract as a potential COVID-19 therapeutic agent in the elderly	24
Nerolidol: a potential approach in rheumatoid arthritis through reduction of TNF-α, IL-1β, IL-6, NF-kB, COX-2 and antioxidant effect in CFA-induced arthritic model	23
Colchicine effectively attenuates inflammatory biomarker high-sensitivity C-reactive protein (hs-CRP) in patients with non-ST-segment elevation myocardial infarction: a randomised, double-blind, place	23
Potential role of lipoxin in the management of COVID-19: a narrative review	23
Current and novel therapeutic targets in the treatment of rheumatoid arthritis	22
Asphodelus tenuifolius extracts arrested inflammation and arthritis through modulation of TNF-α, NF-κB, ILs, and COX-2 activities in in vivo models	22
Thioredoxin-interacting protein (TXNIP) as a target for Alzheimer’s disease: flavonoids and phenols	22
Advancing combination treatment with glycyrrhizin and boswellic acids for hospitalized patients with moderate COVID-19 infection: a randomized clinical trial	21
Protective effect of (+)–catechin against lipopolysaccharide-induced inflammatory response in RAW 264.7 cells through downregulation of NF-κB and p38 MAPK	21
Targeting of neuroinflammation by glibenclamide in Covid-19: old weapon from arsenal	21
Evaluation of antioxidant and anti-ulcerogenic effects of Eremurus persicus (Jaub & Spach) Boiss leaf hydroalcoholic extract on ethanol-induced gastric ulcer in rats	21
Cardiac inflammation and fibrosis following chemo/radiation therapy: mechanisms and therapeutic agents	20
Benzodiazepines in Alzheimer’s disease: beneficial or detrimental effects	20
Ursolic acid and SARS-CoV-2 infection: a new horizon and perspective	20
The role of berberine in Covid-19: potential adjunct therapy	20
Immune-related adverse events (irAEs) in ankylosing spondylitis (AS) patients treated with interleukin (IL)-17 inhibitors: a systematic review and meta-analysis	20
Exogenous stromal cell-derived factor-1 (SDF-1) suppresses the NLRP3 inflammasome and inhibits pyroptosis in synoviocytes from osteoarthritic joints via activation of the AMPK signaling pathway	19
Lipoxin A4 regulates M1/M2 macrophage polarization via FPR2–IRF pathway	19
Hesperetin as an anti-SARS-CoV-2 agent can inhibit COVID-19-associated cancer progression by suppressing intracellular signaling pathways	19
The effect of glutamine supplementation on serum levels of some inflammatory factors, oxidative stress, and appetite in COVID-19 patients: a case–control study	19
Indomethacin loaded dextran stearate polymeric micelles improve adjuvant-induced arthritis in rats: design and in vivo evaluation	19
Chemical constituents and gastro-protective potential of Pachira glabra leaves against ethanol-induced gastric ulcer in experimental rat model	19
Management of Gout-associated MSU crystals-induced NLRP3 inflammasome activation by procyanidin B2: targeting IL-1β and Cathepsin B in macrophages	18
Effects of coenzyme Q10 supplementation on inflammation, angiogenesis, and oxidative stress in breast cancer patients: a systematic review and meta-analysis of randomized controlled- trials	18
Perindopril ameliorates experimental Alzheimer’s disease progression: role of amyloid β degradation, central estrogen receptor and hyperlipidemic-lipid raft signaling	18
Neuroinflammatory responses in Parkinson’s disease: relevance of Ibuprofen in therapeutics	17
SARS-CoV-2 may trigger inflammasome and pyroptosis in the central nervous system: a mechanistic view of neurotropism	17
Management of COVID-19-induced cytokine storm by Keap1-Nrf2 system: a review	17
Anti-inflammatory and anti-hyperalgesic effects of milnacipran in inflamed rats: involvement of myeloperoxidase activity, cytokines and oxidative/nitrosative stress	17
Oral administration of Centella asiatica (L.) Urb leave aqueous extract ameliorates cerebral oxidative stress, inflammation, and apoptosis in male rats with type-2 diabetes	17
Kaempferol potentiates the sensitivity of pancreatic cancer cells to erlotinib via inhibition of the PI3K/AKT signaling pathway and epidermal growth factor receptor	17
Quercetin inhibits caerulein-induced acute pancreatitis through regulating miR-216b by targeting MAP2K6 and NEAT1	16
Evaluating the mucoprotective effects of glycyrrhizic acid-loaded polymeric nanoparticles in a murine model of 5-fluorouracil-induced intestinal mucositis via suppression of inflammatory mediators and	16
Protective effect of andrographolide against STZ induced Alzheimer’s disease in experimental rats: possible neuromodulation and Aβ(1–42) analysis	16
Microglia polarization in nociplastic pain: mechanisms and perspectives	16
Is sitagliptin effective for SARS-CoV-2 infection: false or true prophecy?	16
Elucidating the role of hypoxia-inducible factor in rheumatoid arthritis	16
Bortezomib: a proteasome inhibitor for the treatment of autoimmune diseases	16

The advances of methotrexate resistance in rheumatoid arthritis	16
Targeting intercellular adhesion molecule-1 (ICAM-1) to reduce rhinovirus-induced acute exacerbations in chronic respiratory diseases	16
Chemical characterization and anti-arthritic appraisal of Monotheca buxifolia methanolic extract in Complete Freund’s Adjuvant-induced arthritis in Wistar rats	16
A viral infection explanation for Kawasaki disease in general and for COVID-19 virus-related Kawasaki disease symptoms	15
A review of the biological and pharmacological activities of mesalazine or 5-aminosalicylic acid (5-ASA): an anti-ulcer and anti-oxidant drug	15
Tetrahydrocannabinol and cannabidiol medicines for chronic pain and mental health conditions	15
Orchestrated modulation of rheumatoid arthritis via crosstalking intracellular signaling pathways	15
Selenium, selenoprotein P, and oxidative stress levels in SARS-CoV-2 patients during illness and recovery	15
Dapagliflozin as an autophagic enhancer via LKB1/AMPK/SIRT1 pathway in ovariectomized/d-galactose Alzheimer’s rat model	14
Modulation of KIF17/NR2B crosstalk by tozasertib attenuates inflammatory pain in rats	14
ACEIs, ARBs, ibuprofen originally linked to COVID-19: the other side of the mirror	14
Exploring the role of Aquaporins (AQPs) in LPS induced systemic inflammation and the ameliorative effect of Garcinia in male Wistar rat	14
Innate immune response in systemic autoimmune diseases: a potential target of therapy	14
Metformin ameliorates the status epilepticus- induced hippocampal pathology through possible mTOR modulation	14
Periplaneta americana extract ameliorates dextran sulfate sodium-induced ulcerative colitis via immunoregulatory and PI3K/AKT/NF-κB signaling pathways	14
Venlafaxine demonstrated anti-arthritic activity possibly through down regulation of TNF-α, IL-6, IL-1β, and COX-2	14
Melatonin induces apoptosis and cell cycle arrest in cervical cancer cells via inhibition of NF-κB pathway	13
Minocycline attenuates cholinergic dysfunction and neuro-inflammation-mediated cognitive impairment in scopolamine-induced Alzheimer’s rat model	13
Osteopontin in autoimmune disorders: current knowledge and future perspective	13
Methotrexate and theaflavin-3, 3′-digallate synergistically restore the balance between apoptosis and autophagy in synovial fibroblast of RA: an ex vivo approach with cultured human RA FLS	13
Rutin ameliorates malaria pathogenesis by modulating inflammatory mechanism: an in vitro and in vivo study	13
Phytochemical profiling, in vitro and in vivo anti-inflammatory, analgesic and antipyretic potential of Sesuvium sesuvioides (Fenzl) Verdc. (Aizoaceae)	13
Molecular and pathobiological involvement of fetuin-A in the pathogenesis of NAFLD	13
Biosynthesis of gold nanoparticles for the treatment of osteoarthritis alone or in combination with Diacerein® in a rat model	12
COPD lung studies of Nrf2 expression and the effects of Nrf2 activators	12
Quercetin-loaded chitosan nanoparticles ameliorate adjuvant-induced arthritis in rats by regulating anti-oxidant enzymes and downregulating pro- and inflammatory cytokines	12
Preclinical evidence for quercetin against inflammatory bowel disease: a meta-analysis and systematic review	12
Methanolic extracts of a selected Egyptian Vicia faba cultivar mitigate the oxidative/inflammatory burden and afford neuroprotection in a mouse model of Parkinson’s disease	12
A story of the potential effect of non-steroidal anti-inflammatory drugs (NSAIDs) in Parkinson’s disease: beneficial or detrimental effects	12
The risk of mortality in patients with COVID-19 with pre-diagnosis use of NSAIDs: a meta-analysis	12
The protective effect of Sophora japonica on prostatic hypertrophy and inflammation in rat	12
Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases	12
Pterostilbene improves CFA-induced arthritis and peripheral neuropathy through modulation of oxidative stress, inflammatory cytokines and neurotransmitters in Wistar rats	12
Anti-inflammatory potential of Empagliflozin	12
Lycopene: a therapeutic strategy against coronavirus disease 19 (COVID- 19)	12
Reduced cutaneous inflammation associated with antioxidant action after topical application of the aqueous extract of Annona muricata leaves	12
Diapocynin neuroprotective effects in 3-nitropropionic acid Huntington’s disease model in rats: emphasis on Sirt1/Nrf2 signaling pathway	12
Nuciferine attenuates lipopolysaccharide-stimulated inflammatory responses by inhibiting p38 MAPK/ATF2 signaling pathways	12
Dimethyl fumarate attenuates 2-VO-induced vascular dementia via activating the Nrf2 signaling pathway in rats	11
Long-term use of metformin and Alzheimer’s disease: beneficial or detrimental effects	11
Tannic acid alleviates experimental pulmonary fibrosis in mice by inhibiting inflammatory response and fibrotic process	11
Myeloid-derived suppressor cells (MDSCs) in brain cancer: challenges and therapeutic strategies	11
The role of adenosine receptor ligands on inflammatory pain: possible modulation of TRPV1 receptor function	11
Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases	11
Phenols and terpenoids: natural products as inhibitors of NLRP3 inflammasome in cardiovascular diseases	11
Pharmacological evaluation of anti-arthritic potential of terpinen-4-ol using in vitro and in vivo assays	11
Role of Myeloid-derived suppressor cell (MDSC) in autoimmunity and its potential as a therapeutic target	11
Neuroprotective effects of roflumilast against quinolinic acid-induced rat model of Huntington’s disease through inhibition of NF-κB mediated neuroinflammatory markers and activation of cAMP/CREB/BDNF	11
Advancement of nanomedicines in chronic inflammatory disorders	11
Role of intracellular signaling pathways and their inhibitors in the treatment of inflammation	11
Miconia albicans and Curcuma longa herbal medicines positively modulate joint pain, function and inflammation in patients with osteoarthritis: a clinical study	11
Diosmetin, a novel transient receptor potential vanilloid 1 antagonist, alleviates the UVB radiation-induced skin inflammation in mice	10
Methyl 3,4,5-trimethoxycinnamate suppresses inflammation in RAW264.7 macrophages and blocks macrophage–adipocyte interaction	10
Modulation of inflammatory pathways, medicinal uses and toxicities of Uvaria species: potential role in the prevention and treatment of inflammation	10
The wound healing effect of botanicals and pure natural substances used in in vivo models	10
Beneficial effects of secretome derived from mesenchymal stem cells with stigmasterol to negate IL-1β-induced inflammation in-vitro using rat chondrocytes—OA management	10
Salt-dependent hypertension and inflammation: targeting the gut–brain axis and the immune system with Brazilian green propolis	10
Donepezil attenuates injury following ischaemic stroke by stimulation of neurogenesis, angiogenesis, and inhibition of inflammation and apoptosis	10
The anti-angiogenesis mechanism of Geniposide on rheumatoid arthritis is related to the regulation of PTEN	10
Role of the NRG1/ErbB4 and PI3K/AKT/mTOR signaling pathways in the anti-psychotic effects of aripiprazole and sertindole in ketamine-induced schizophrenia-like behaviors in rats	10
APPA (apocynin and paeonol) modulates pathological aspects of human neutrophil function, without supressing antimicrobial ability, and inhibits TNFα expression and signalling	10
The potential therapeutic effect of statins in multiple sclerosis: beneficial or detrimental effects	10
Could the fibromyalgia syndrome be triggered or enhanced by COVID-19?	10
Novel anti-arthritic mechanisms of trans-cinnamaldehyde against complete Freund’s adjuvant-induced arthritis in mice: involvement of NF-кB/TNF-α and IL-6/IL-23/ IL-17 pathways in the immuno-inflammato	10
Immunomodulatory effect of diallyl sulfide on experimentally-induced benign prostate hyperplasia via the suppression of CD4+T/IL-17 and TGF-β1/ERK pathways	10
The effects of berberine on inflammatory markers in Chinese patients with metabolic syndrome and related disorders: a meta‑analysis of randomized controlled trials	10
Cancer vs. SARS-CoV-2 induced inflammation, overlapping functions, and pharmacological targeting	10
Amelioration of oxidative stress, cholinergic dysfunction, and neuroinflammation in scopolamine-induced amnesic rats fed with pomegranate seed	9
Antinociception induced by artemisinin nanocapsule in a model of postoperative pain via spinal TLR4 inhibition	9
Current jakinibs for the treatment of rheumatoid arthritis: a systematic review	9
Cell-free probiotic supernatant (CFS) treatment alleviates indomethacin-induced enterocolopathy in BALB/c mice by down-modulating inflammatory response and oxidative stress: potential alternative targ	9
Effects of hydro-ethanolic extract of leaves of Maesa lanceolata (Mursinaceae) on acetic acid-induced ulcerative colitis in rats	9
Review of natural compounds for potential psoriasis treatment	9
Protective effect of methyl gallate on murine antigen-induced arthritis by inhibiting inflammatory process and bone erosion	9
Silymarin constrains diacetyl-prompted oxidative stress and neuroinflammation in rats: involvements of Dyn/GDNF and MAPK signaling pathway	9
In vitro biological potential of the essential oil of some aromatic species used in Iranian traditional medicine	9
Osteoarthritis complications and the recent therapeutic approaches	9
Long noncoding RNA intersectin 1-2 gradually declines during adalimumab treatment, and its reduction correlates with treatment efficacy in patients with ankylosing spondylitis	9
Shedding light on vitamin D: the shared mechanistic and pathophysiological role between hypovitaminosis D and COVID-19 risk factors and complications	9
NSAIDs and Kelleni’s protocol as potential early COVID-19 treatment game changer: could it be the final countdown?	9

New insights into geraniol’s antihemolytic, anti-inflammatory, antioxidant, and anticoagulant potentials using a combined biological and in silico screening strategy	9
The effect of ramatroban on cytokine and thrombotic storms in Covid-19	9
Omicron variant evolution on vaccines and monoclonal antibodies	9
COVID-19 and nutriceutical therapies, especially using zinc to supplement antimicrobials	9
Melatonin ameliorates spatial memory and motor deficits via preserving the integrity of cortical and hippocampal dendritic spine morphology in mice with neurotrauma	9
Immunomodulatory effects of umbilical mesenchymal stem cell-derived exosomes on CD4+ T cells in patients with primary Sjögren's syndrome	9
Comparison of individual and combination treatments with naproxen, prednisolone and hydroxychloroquine to treat Complete Freund’s Adjuvant induced arthritis	9
The positive effect of pregnancy in rheumatoid arthritis and the use of medications for the management of rheumatoid arthritis during pregnancy	8
Actions of Cannabis sativa L. fixed oil and nano-emulsion on venom-induced inflammation of Bothrops moojeni snake in rats	8
Infliximab prevents systemic bone loss and suppresses tendon inflammation in a collagen-induced arthritis rat model	8
Anti-inflammatory and antioxidant properties of Alternanthera brasiliana improve cutaneous wound healing in rats	8
Cellular mechanisms and molecular pathways linking bitter taste receptor signalling to cardiac inflammation, oxidative stress, arrhythmia and contractile dysfunction in heart diseases	8
Pharmaco-immunomodulatory interventions for averting cytokine storm-linked disease severity in SARS-CoV-2 infection	8
Memantine and Ibuprofen pretreatment exerts anti-inflammatory effect against streptozotocin-induced astroglial inflammation via modulation of NMDA receptor-associated downstream calcium ion signaling	8
Pharmacodynamic mechanisms of anti-inflammatory drugs on the chemosensitization of multidrug-resistant cancers and the pharmacogenetics effectiveness	8
Antioxidants: an approach for restricting oxidative stress induced neurodegeneration in Alzheimer’s disease	8
Fatigue, sleepiness and sleep quality are SARS-CoV-2 variant independent in patients with long COVID symptoms	8
MiR-200a inversely correlates with Hedgehog and TGF-β canonical/non-canonical trajectories to orchestrate the anti-fibrotic effect of Tadalafil in a bleomycin-induced pulmonary fibrosis model	8
Inflawell® improves neutrophil-to-lymphocyte ratio and shortens hospitalization in patients with moderate COVID-19, in a randomized double-blind placebo-controlled clinical trial	8
A pilot safety, tolerability and pharmacokinetic study of an oro-buccal administered cannabidiol-dominant anti-inflammatory formulation in healthy individuals: a randomized placebo-controlled single-b	8
The effects of pomegranate consumption on inflammatory and oxidative stress biomarkers in adults: a systematic review and meta-analysis	8
Development and evaluation emulgel for effective management of the imiquimod-induced psoriasis	8
Repurposing monoamine oxidase inhibitors (MAOI) for the treatment of rheumatoid arthritis possibly through modulating reactive oxidative stress mediated inflammatory cytokines	8
Tumor necrosis factor alpha (TNF-α) blockage reduces acute inflammation and delayed wound healing in oral ulcer of rats	8
The crosstalk among TLR2, TLR4 and pathogenic pathways; a treasure trove for treatment of diabetic neuropathy	8
In vitro and in vivo assessment of the anti-inflammatory activity of olive leaf extract in rats	8
Spermine protects aluminium chloride and iron-induced neurotoxicity in rat model of Alzheimer's disease via attenuation of tau phosphorylation, Amyloid-β (1–42) and NF-κB pathway	8
Association between metabolic associated fatty liver disease and osteoarthritis using data from the Korean national health and nutrition examination survey (KNHANES)	8
Oral administration of essential oil from Psidium glaziovianum Kiaersk leaves alleviates pain and inflammation in mice	8
Neuroprotective effect of tangeretin against chromium-induced acute brain injury in rats: targeting Nrf2 signaling pathway, inflammatory mediators, and apoptosis	8
Brain insulin resistance linked Alzheimer’s and Parkinson’s disease pathology: An undying implication of epigenetic and autophagy modulation	8
A cellular and molecular biology-based update for ivermectin against COVID-19: is it effective or non-effective?	8
Maltol ameliorates intervertebral disc degeneration through inhibiting PI3K/AKT/NF-κB pathway and regulating NLRP3 inflammasome-mediated pyroptosis	8
What is really ‘Long COVID’?	8