Cancer Gene Therapy

Article	Citations
Reviewer Recognition	110
Immuno-regulatory malignant B cells contribute to Chronic Lymphocytic Leukemia progression	91
Retraction Note: Upregulating microRNA-498 inhibits gastric cancer proliferation invasion and chemoresistance through inverse interaction of Bmi1	71
Retraction Note: Tumor suppressor microRNA-31 inhibits gastric carcinogenesis by targeting Smad4 and SGPP2	67
Retraction Note: MicroRNA-23a enhances migration and invasion through PTEN in osteosarcoma	62
Reducing the risks of nuclear war—the role of health professionals	58
Exploring metabolic reprogramming in esophageal cancer: the role of key enzymes in glucose, amino acid, and nucleotide pathways and targeted therapies	52
HPV status represents dominant trait driving delineation of survival-associated gene co-expression networks in head and neck cancer	47
Circ-GSK3B up-regulates GSK3B to suppress the progression of lung adenocarcinoma	45
P38 kinase in gastrointestinal cancers	44
Pbx3-mediated suppression of type I interferon response contributes to leukemia progression driven by MLL-AF9	43
Nrf2 overexpression increases the resistance of acute myeloid leukemia to cytarabine by inhibiting replication factor C4	42
Therapeutic efficacy of the novel SHP2 degrader SHP2-D26, alone or in combination, against lung cancer is associated with modulation of p70S6K/S6, Bim and Mcl-1	42
Targeting CLK4 inhibits the metastasis and progression of breast cancer by inactivating TGF-β pathway	39
Sorting nexin-dependent therapeutic targeting of oncogenic epidermal growth factor receptor	37
Correction to: An investigation of Sigma-1 receptor expression and ligand-induced endoplasmic reticulum stress in breast cancer	33
DRAIC promotes growth of breast cancer by sponging miR-432-5p to upregulate SLBP	32
Correction to: Single-cell RNA sequencing reveals changes in glioma-associated macrophage polarization and cellular states of malignant gliomas with high AQP4 expression	31
Correction: Nrf2 overexpression increases the resistance of acute myeloid leukemia to cytarabine by inhibiting replication factor C4	30
MCPIP1 Suppresses the NF-κB Signaling Pathway Through Negative Regulation of K63-Linked Ubiquitylation of TRAF6 in Colorectal Cancer	30
The cross-talk of cancer-associated fibroblasts assist in prognosis and immunotherapy in patients with breast carcinoma	30
Cytoplasmic localization of IRF5 induces Wnt5a/E-cadherin degradation and promotes gastric cancer cells metastasis	29
SMYD3 regulates gastric cancer progression and macrophage polarization through EZH2 methylation	29
Lysine-40 succinylation of TAGLN2 induces glioma angiogenesis and tumor growth through regulating TMSB4X	29
Proteomic time course of breast cancer cells highlights enhanced sensitivity to Stat3 and Src inhibitors prior to endocrine resistance development	26

RNA N6-methyladenosine (m6A) modification in HNSCC: molecular mechanism and therapeutic potential	25
Single-cell discovery of the scene and potential immunotherapeutic target in hypopharyngeal tumor environment	25
Respective roles of Pik3ca mutations and cyproterone acetate impregnation in mouse meningioma tumorigenesis	25
Cancer-associated fibroblast exosomes promote prostate cancer metastasis through miR-500a-3p/FBXW7/HSF1 axis under hypoxic microenvironment	25
MORC4 plays a tumor-promoting role in colorectal cancer via regulating PCGF1/CDKN1A axis in vitro and in vivo	25
Modification of the tumor microenvironment enhances immunity with plasmid gene therapy	24
Inhibition of the galactosyltransferase C1GALT1 reduces osteosarcoma cell proliferation by interfering with ERK signaling and cell cycle progression	24
Role of MARK2 in the nervous system and cancer	24
Romidepsin exhibits anti-esophageal squamous cell carcinoma activity through the DDIT4-mTORC1 pathway	24
Caffeic acid phenethyl ester suppresses the expression of androgen receptor variant 7 via inhibition of CDK1 and AKT	24
The long-term effectiveness and mechanism of oncolytic virotherapy combined with anti-PD-L1 antibody in colorectal cancer patient	23
Gastrointestinal infections and gastrointestinal haemorrhage are underestimated but serious adverse events in chimeric antigen receptor T-cell recipients: A real-world study	23
miR-124-3p and miR-194-5p regulation of the PI3K/AKT pathway via ROR2 in medulloblastoma progression	23
TSPAN1 inhibits metastasis of nasopharyngeal carcinoma via suppressing NF-kB signaling	22
Pathophysiological role of ion channels and transporters in hepatocellular carcinoma	21
RevCAR-expressing immune effector cells for targeting of Fn14-positive glioblastoma	21
Gut microbiota-mediated activation of GSDMD ignites colorectal tumorigenesis	21
Correction: SPRTN is involved in hepatocellular carcinoma development through the ER stress response	21
IGF2BP2-modified circular RNA circCHD7 promotes endometrial cancer progression via stabilizing PDGFRB and activating JAK/STAT signaling pathway	21
Caveolin-1 knockout mitigates breast cancer metastasis to the lungs via integrin α3 dysregulation in 4T1-induced syngeneic breast cancer model	20
Retraction Note: Circular RNA hsa_circ_0009172 suppresses gastric cancer by regulation of microRNA-485-3p-mediated NTRK3	19
Integrating system biology and intratumor gene therapy by trans-complementing the appropriate co-stimulatory molecule as payload in oncolytic herpes virus	19
BAG2, MAD2L1, and MDK are cancer-driver genes and candidate targets for novel therapies in malignant pleural mesothelioma	19
PIK3CA mutation fortifies molecular determinants for immune signaling in vascular cancers	19
Atypical cellular responses mediated by intracellular constitutive active TrkB (NTRK2) kinase domains and a solely intracellular NTRK2-fusion oncogene	19
Suppression of fatty acid oxidation supports pancreatic cancer growth and survival under hypoxic conditions through autophagy induction	18
Cannabinoids orchestrate cross-talk between cancer cells and endothelial cells in colorectal cancer	17
Correction: UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53	17
RETRACTED ARTICLE: Targeting KDM1B-dependent miR-215-AR-AGR2-axis promotes sensitivity to enzalutamide-resistant prostate cancer	17
Correction: Cholenic acid derivative UniPR1331 impairs tumor angiogenesis via blockade of VEGF/VEGFR2 in addition to Eph/ephrin	16
Pan-cancer methylome analysis for cancer diagnosis and classification of cancer cell of origin	16
Transcription factor p53-mediated activation of miR-519d-3p and downregulation of E2F1 attenuates prostate cancer growth and metastasis	16
Correction: Cancer-associated fibroblasts: overview, progress, challenges, and directions	16
Alternative splicing events in tumor immune infiltration in renal clear cell carcinomas	16
Publisher Correction: Exosomal LINC00161 promotes angiogenesis and metastasis via regulating miR-590-3p/ROCK axis in hepatocellular carcinoma	16
NCOA3, a new player in melanoma susceptibility and a therapeutic target	16
SIX3 function in cancer: progression and comprehensive analysis	15
Homeostatic cytokines tune naivety and stemness of cord blood-derived transgenic T cells	15
GLIPR1 promotes proliferation, metastasis and 5-fluorouracil resistance in hepatocellular carcinoma by activating the PI3K/PDK1/ROCK1 pathway	15
Correction: Silencing of long non-coding RNA LINC01270 inhibits esophageal cancer progression and enhances chemosensitivity to 5-fluorouracil by mediating GSTP1methylation	15
YAP 5-methylcytosine modification increases its mRNA stability and promotes the transcription of exosome secretion-related genes in lung adenocarcinoma	14
Creation of Philadelphia chromosome by CRISPR/Cas9-mediated double cleavages on BCR and ABL1 genes as a model for initial event in leukemogenesis	14
Global characterization of megakaryocytes in bone marrow, peripheral blood, and cord blood by single-cell RNA sequencing	14
Correction to: Nogo-B receptor increases glycolysis and the paclitaxel resistance of estrogen receptor-positive breast cancer via the HIF-1α-dependent pathway	14
Correction to: Identification of a five genes prognosis signature for triple-negative breast cancer using multi-omics methods and bioinformatics analysis	14
Correction to: MicroRNA-21 guide and passenger strand regulation of adenylosuccinate lyase-mediated purine metabolism promotes transition to an EGFR-TKI-tolerant persister state	14
NCBP2 and TFRC are novel prognostic biomarkers in oral squamous cell carcinoma	13
Correction: Arsenic trioxide and p97 inhibitor synergize against acute myeloid leukemia by targeting nascent polypeptides and activating the ZAKα–JNK pathway	13
Long noncoding RNA LINC00173 induces radioresistance in nasopharyngeal carcinoma via inhibiting CHK2/P53 pathway	13
Detection of (pre)cancerous colorectal lesions in Lynch syndrome patients by microsatellite instability liquid biopsy	13

Oncolytic virus encoding 4-1BBL and IL15 enhances the efficacy of tumor-infiltrating lymphocyte adoptive therapy in HCC	13
FUT6 inhibits the proliferation, migration, invasion, and EGF-induced EMT of head and neck squamous cell carcinoma (HNSCC) by regulating EGFR/ERK/STAT signaling pathway	13
Serum small extracellular vesicles-derived BST2 as a biomarker for papillary thyroid microcarcinoma promotes lymph node metastasis	13
Therapeutic applications of local injection of hsa-miR-634 into canine spontaneous malignant melanoma tumors	13
Correction: TMEM158 promotes the proliferation and migration of glioma cells via STAT3 signaling in glioblastomas	13
BAIAP2L2 promotes the malignancy of hepatocellular carcinoma via GABPB1-mediated reactive oxygen species imbalance	13
Centromere protein F promotes progression of hepatocellular carcinoma through ERK and cell cycle-associated pathways	13
Long-term response to autologous anti-CD19 chimeric antigen receptor T cells in relapsed or refractory B cell acute lymphoblastic leukemia: a systematic review and meta-analysis	13
FOXM1 promotes neurofibromatosis type 1-associated malignant peripheral nerve sheath tumor progression in a NUF2-dependent manner	13
STAT5a and SH2B3 novel mutations display malignancy roles in a triple-negative primary myelofibrosis patient	13
M2 macrophage exosomal LINC01001 promotes non-small cell lung cancer development by affecting METTL3 and glycolysis pathway	13
Small extracellular vesicle TGF-β in cancer progression and immune evasion	13
Recent advances in the role of circRNA in cisplatin resistance in tumors	12
SDCBP modulates tumor microenvironment, tumor progression and anti-PD1 efficacy in colorectal cancer	12
Use of CRISPR-based screens to identify mechanisms of chemotherapy resistance	12
Next generation self-replicating RNA vectors for vaccines and immunotherapies	12
Extracellular sialyltransferase st6gal1 in breast tumor cell growth and invasiveness	12
A novel RIP1-mediated canonical WNT signaling pathway that promotes colorectal cancer metastasis via β -catenin stabilization-induced EMT	12
MDSC checkpoint blockade therapy: a new breakthrough point overcoming immunosuppression in cancer immunotherapy	12
ARID2 suppression promotes tumor progression and upregulates cytokeratin 8, 18 and β-4 integrin expression in TP53-mutated tobacco-related oral cancer and has prognostic implications	12
ADAM12 expression is upregulated in cancer cells upon radiation and constitutes a prognostic factor in rectal cancer patients following radiotherapy	12
ITGA3 promotes pancreatic cancer progression through HIF1α- and c-Myc-driven glycolysis in a collagen I-dependent autocrine manner	12
The KRAS-G12C inhibitor: activity and resistance	12
m6A reader IGF2BP2 promotes lymphatic metastasis by stabilizing DPP4 in papillary thyroid carcinoma	12
TMEM158 promotes the proliferation and migration of glioma cells via STAT3 signaling in glioblastomas	12
Adeno-associated virus-delivered alpha synuclein inhibits bladder cancer growth via the p53/p21 signaling pathway	12
Acute myeloid leukemia cell-derived extracellular vesicles carrying microRNA-548ac regulate hematopoietic function via the TRIM28/STAT3 pathway	12
An alternative fully human anti-BCMA CAR-T shows response for relapsed or refractory multiple myeloma with anti-BCMA CAR-T exposures previously	11
The FOXP1-ABCG2 axis promotes the proliferation of cancer stem cells and induces chemoresistance in pancreatic cancer	11
Clonal dynamics limits detection of selection in tumour xenograft CRISPR/Cas9 screens	11
Correction: microRNA-let-7e in serum-derived exosomes inhibits the metastasis of non-small-cell lung cancer in a SUV39H2/LSD1/CDH1-dependent manner	11
Mesothelin expression correlates with elevated inhibitory immune activity in patients with colorectal cancer	11
Ferroptosis enhances the therapeutic potential of oncolytic adenoviruses KD01 against cancer	11
Correction to: Therapeutic efficacy of the novel SHP2 degrader SHP2-D26, alone or in combination, against lung cancer is associated with modulation of p70S6K/S6, Bim and Mcl-1	11
3JC48-3 (methyl 4′-methyl-5-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-[1,1′-biphenyl]-3-carboxylate): a novel MYC/MAX dimerization inhibitor reduces prostate cancer growth	11
MBD1 protects replication fork stability by recruiting PARP1 and controlling transcription-replication conflicts	11
Lower ratio of IMPDH1 to IMPDH2 sensitizes gliomas to chemotherapy	11
Silencing of RND3/RHOE inhibits the growth of human hepatocellular carcinoma and is associated with reversible senescence	11
A critical ETV4/Twist1/Vimentin axis in Ha-RAS-induced aggressive breast cancer	11
Intrinsic S phase checkpoint enforced by an antiproliferative oncosuppressor cytokine	10
Somatic copy number alteration predicts clinical benefit of lung adenocarcinoma patients treated with cytokine-induced killer plus chemotherapy	10
TMPRSS2-ERG promotes the initiation of prostate cancer by suppressing oncogene-induced senescence	10
Inhibition of myeloid PD-L1 suppresses osteoclastogenesis and cancer bone metastasis	10
Elevated GIGYF2 expression suppresses tumor migration and enhances sensitivity to temozolomide in malignant glioma	10
Expressed prognostic biomarkers for primary prostate cancer independent of multifocality and transcriptome heterogeneity	10
Retraction Note: microRNA-211-mediated targeting of the INHBA-TGF-β axis suppresses prostate tumor formation and growth	10
Blocked metabotropic glutamate receptor 5 enhances chemosensitivity in hepatocellular carcinoma and attenuates chemotoxicity in the normal liver by regulating DNA damage	10
Cutting both ways: the innate immune response to oncolytic virotherapy	10
Publisher Correction: Heat shock protein-90alpha (Hsp90α) stabilizes hypoxia-inducible factor-1α (HIF-1α) in support of spermatogenesis and tumorigenesis	10
Targeting GNAQ/11 through PKC inhibition in uveal melanoma	10
Identification of an immune gene-associated prognostic signature in patients with bladder cancer	10
Correction to: FOXO3-induced lncRNA LOC554202 contributes to hepatocellular carcinoma progression via the miR-485-5p/BSG axis	10
Protein kinase inhibitor responses in uveal melanoma reflects a diminished dependency on PKC-MAPK signaling	9
PDPN contributes to constructing immunosuppressive microenvironment in IDH wildtype glioma	9
Novel long noncoding RNA LINC02820 augments TNF signaling pathway to remodel cytoskeleton and potentiate metastasis in esophageal squamous cell carcinoma	9
Role of non-coding RNAs in neuroblastoma	9
Ribosomal S6 protein kinase 4 promotes resistance to EZH2 inhibitors in glioblastoma	9
Molecular crosstalk between CUEDC2 and ERα influences the clinical outcome by regulating mitosis in breast cancer	9
Regional infusion of a class C TLR9 agonist enhances liver tumor microenvironment reprogramming and MDSC reduction to improve responsiveness to systemic checkpoint inhibition	9
Loss of EPS8 sensitizes non-small-cell lung carcinoma to chemotherapy-induced DNA damage	9
FIT links c-Myc and P53 acetylation by recruiting RBBP7 during colorectal carcinogenesis	9
Tafazzin mediates tamoxifen resistance by regulating cellular phospholipid composition in ER-positive breast cancer	9
Pharmacological targeting of CBP/p300 drives a redox/autophagy axis leading to senescence-induced growth arrest in non-small cell lung cancer cells	9
Correction to: Activation of CEACAM1 with an agonistic monoclonal antibody results in inhibition of melanoma cells	9
LncRNA-NEF suppressed oxaliplatin resistance and epithelial-mesenchymal transition in colorectal cancer through epigenetically inactivating MEK/ERK signaling	9
Estrogen receptor status heterogeneity in breast cancer tumor: role in response to endocrine treatment	9
Production of an interleukin-10 blocking antibody by genetically engineered macrophages increases cancer cell death in human gastrointestinal tumor slice cultures	9
TNFRSF19 promotes endoplasmic reticulum stress-induced paraptosis via the activation of the MAPK pathway in triple-negative breast cancer cells	8
Leveraging synthetic lethality to uncover potential therapeutic target in gastric cancer	8
Identification of lineage-specific epigenetic regulators FOXA1 and GRHL2 through chromatin accessibility profiling in breast cancer cell lines	8
Baicalein inhibits cell proliferation and induces apoptosis in brain glioma cells by downregulating the LGR4-EGFR pathway	8
NF-κB-activated oncogene inhibition strategy for cancer gene therapy	8
Arvanil induces ferroptosis of hepatocellular carcinoma by binding to MICU1	8
Schwann cell derived pleiotrophin stimulates fibroblast for proliferation and excessive collagen deposition in plexiform neurofibroma	8
Targeting TLK2 inhibits the progression of gastric cancer by reprogramming amino acid metabolism through the mTOR/ASNS axis	8
Hsa_circ_0007590/PTBP1 complex reprograms glucose metabolism by reducing the stability of m6A-modified PTEN mRNA in pancreatic ductal adenocarcinoma	8
CircPKN2 promotes ferroptosis in bladder cancer by promoting the ubiquitination of Stearoyl-CoA Desaturase 1	8
Research progress and application of single-cell sequencing in head and neck malignant tumors	8
A novel intranasal peptide vaccine inhibits non-small cell lung cancer with KRAS mutation	8
Long noncoding RNA EPCART regulates translation through PI3K/AKT/mTOR pathway and PDCD4 in prostate cancer	8

N6-methyladenosine modification of RIMS binding protein 2 promotes head and neck squamous cell carcinoma proliferation and radiotherapy tolerance through endoplasmic reticulum stress	8
UGT1A7 altered HER2-positive breast cancer response to trastuzumab by affecting epithelial-to-mesenchymal transition: A potential biomarker to identify patients resistant to trastuzumab treatment	8