Cancer Gene Therapy

Article	Citations
Revisiting the role of CD4+ T cells in cancer immunotherapy—new insights into old paradigms	447
Key chemokines direct migration of immune cells in solid tumors	193
Cancer-associated fibroblasts: overview, progress, challenges, and directions	160
Interplay between MTOR and GPX4 signaling modulates autophagy-dependent ferroptotic cancer cell death	132
METTL3-mediated maturation of miR-126-5p promotes ovarian cancer progression via PTEN-mediated PI3K/Akt/mTOR pathway	98
The KRAS-G12C inhibitor: activity and resistance	66
ESCRT-III-mediated membrane repair in cell death and tumor resistance	55
LOX-1 and cancer: an indissoluble liaison	53
Use of CAR T-cell for acute lymphoblastic leukemia (ALL) treatment: a review study	52
HDAC3-dependent transcriptional repression of FOXA2 regulates FTO/m6A/MYC signaling to contribute to the development of gastric cancer	51
Nanomedicine-based cancer immunotherapy: recent trends and future perspectives	46
Roles of miRNA dysregulation in the pathogenesis of multiple myeloma	40
Expression pattern of m6A regulators is significantly correlated with malignancy and antitumor immune response of breast cancer	39
Autophagy and gastrointestinal cancers: the behind the scenes role of long non-coding RNAs in initiation, progression, and treatment resistance	39
Hsa_circRNA_102002 facilitates metastasis of papillary thyroid cancer through regulating miR-488-3p/HAS2 axis	39
Combination therapy with CAR T cells and oncolytic viruses: a new era in cancer immunotherapy	39
CXCR4 and anti-BCMA CAR co-modified natural killer cells suppress multiple myeloma progression in a xenograft mouse model	37
Mesenchymal stem cell (MSC)-derived exosomes as novel vehicles for delivery of miRNAs in cancer therapy	36
Exosomal LINC00161 promotes angiogenesis and metastasis via regulating miR-590-3p/ROCK axis in hepatocellular carcinoma	34
TCR-like CARs and TCR-CARs targeting neoepitopes: an emerging potential	33
Oncolytic adenoviruses synergistically enhance anti-PD-L1 and anti-CTLA-4 immunotherapy by modulating the tumour microenvironment in a 4T1 orthotopic mouse model	33
Extracellular vesicles-encapsulated microRNA-10a-5p shed from cancer-associated fibroblast facilitates cervical squamous cell carcinoma cell angiogenesis and tumorigenicity via Hedgehog signaling path	31
Oncolytic virus promotes tumor-reactive infiltrating lymphocytes for adoptive cell therapy	29
LncRNA LINC01857 promotes cell growth and diminishes apoptosis via PI3K/mTOR pathway and EMT process by regulating miR-141-3p/MAP4K4 axis in diffuse large B-cell lymphoma	29
The V-ATPases in cancer and cell death	29

Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40	28
GINS2 promotes EMT in pancreatic cancer via specifically stimulating ERK/MAPK signaling	28
Cytokine-enhanced cytolytic activity of exosomes from NK Cells	27
Protein post-translational modifications in the regulation of cancer hallmarks	27
MicroRNA-375 represses tumor angiogenesis and reverses resistance to sorafenib in hepatocarcinoma	26
LncRNA KCNQ1OT1 facilitates the progression of bladder cancer by targeting MiR-218-5p/HS3ST3B1	26
Elevating microRNA-1-3p shuttled by cancer-associated fibroblasts-derived extracellular vesicles suppresses breast cancer progression and metastasis by inhibiting GLIS1	26
Chimeric Antigen Receptor-modified T cells targeting EphA2 for the immunotherapy of paediatric bone tumours	26
Recent updates on chimeric antigen receptor T cell therapy for hepatocellular carcinoma	25
circSFMBT1 promotes pancreatic cancer growth and metastasis via targeting miR-330-5p/PAK1 axis	25
LncRNAs in breast cancer: a link to future approaches	24
LncRNA HLA-F-AS1 promotes colorectal cancer metastasis by inducing PFN1 in colorectal cancer-derived extracellular vesicles and mediating macrophage polarization	23
The changing face of gastric cancer: epidemiologic trends and advances in novel therapies	23
Anti-SSTR2 antibody-drug conjugate for neuroendocrine tumor therapy	23
Lipid-related FABP5 activation of tumor-associated monocytes fosters immune privilege via PD-L1 expression on Treg cells in hepatocellular carcinoma	22
Long non-coding RNA HAND2-AS1 delays cervical cancer progression via its regulation on the microRNA-21-5p/TIMP3/VEGFA axis	22
YY1-mediated long non-coding RNA Kcnq1ot1 promotes the tumor progression by regulating PTEN via DNMT1 in triple negative breast cancer	22
Extracellular sialyltransferase st6gal1 in breast tumor cell growth and invasiveness	22
PRMT5: a putative oncogene and therapeutic target in prostate cancer	21
Regulation of DNA methylation machinery by epi-miRNAs in human cancer: emerging new targets in cancer therapy	21
LincRNA-ROR is activated by H3K27 acetylation and induces EMT in retinoblastoma by acting as a sponge of miR-32 to activate the Notch signaling pathway	21
EPHA5 mutation predicts the durable clinical benefit of immune checkpoint inhibitors in patients with lung adenocarcinoma	21
Silencing of long non-coding RNA LINC01270 inhibits esophageal cancer progression and enhances chemosensitivity to 5-fluorouracil by mediating GSTP1methylation	20
FOXO3-induced lncRNA LOC554202 contributes to hepatocellular carcinoma progression via the miR-485-5p/BSG axis	20
Fatty acid β-oxidation promotes breast cancer stemness and metastasis via the miRNA-328-3p-CPT1A pathway	20
circRACGAP1 promotes non-small cell lung cancer proliferation by regulating miR-144-5p/CDKL1 signaling pathway	20
Delivery technologies to engineer natural killer cells for cancer immunotherapy	20
Genetically engineered mesenchymal stem cells: targeted delivery of immunomodulatory agents for tumor eradication	19
Overcoming target epitope masking resistance that can occur on low-antigen-expresser AML blasts after IL-1RAP chimeric antigen receptor T cell therapy using the inducible caspase 9 suicide gene safety	19
Upregulated lncRNA DLX6-AS1 underpins hepatocellular carcinoma progression via the miR-513c/Cul4A/ANXA10 axis	19
LncRNA UCA1 promotes SOX12 expression in breast cancer by regulating m6A modification of miR-375 by METTL14 through DNA methylation	19
Heat shock protein-90alpha (Hsp90α) stabilizes hypoxia-inducible factor-1α (HIF-1α) in support of spermatogenesis and tumorigenesis	18
An organoid-based drug screening identified a menin-MLL inhibitor for endometrial cancer through regulating the HIF pathway	18
Vector engineering, strategies and targets in cancer gene therapy	18
SNHG17/miR-384/ELF1 axis promotes cell growth by transcriptional regulation of CTNNB1 to activate Wnt/β-catenin pathway in oral squamous cell carcinoma	18
Viral vectors and extracellular vesicles: innate delivery systems utilized in CRISPR/Cas-mediated cancer therapy	18
Synergistic tumor inhibition of colon cancer cells by nitazoxanide and obeticholic acid, a farnesoid X receptor ligand	17
LncRNA MAGI2-AS3 inhibits tumor progression and angiogenesis by regulating ACY1 via interacting with transcription factor HEY1 in clear cell renal cell carcinoma	17
SHMT2 promotes cell viability and inhibits ROS-dependent, mitochondrial-mediated apoptosis via the intrinsic signaling pathway in bladder cancer cells	17
Post-translational modifications of tubulin: their role in cancers and the regulation of signaling molecules	17
LncRNA SNHG5 promotes the proliferation and cancer stem cell-like properties of HCC by regulating UPF1 and Wnt-signaling pathway	17
TMEM158 promotes the proliferation and migration of glioma cells via STAT3 signaling in glioblastomas	17
RHPN1-AS1 promotes cell proliferation and migration via miR-665/Akt3 in ovarian cancer	17
BATF3 promotes malignant phenotype of colorectal cancer through the S1PR1/p-STAT3/miR-155-3p/WDR82 axis	17
Targeting the androgen receptor to enhance NK cell killing efficacy in bladder cancer by modulating ADAR2/circ_0001005/PD-L1 signaling	16
Apatinib prevents natural killer cell dysfunction to enhance the efficacy of anti-PD-1 immunotherapy in hepatocellular carcinoma	16
Recent advances in immune therapies for gastric cancer	16
Long non-coding RNA LINC02446 suppresses the proliferation and metastasis of bladder cancer cells by binding with EIF3G and regulating the mTOR signalling pathway	16
Circular RNA hsa_circ_0009172 suppresses gastric cancer by regulation of microRNA-485-3p-mediated NTRK3	15
microRNA-let-7e in serum-derived exosomes inhibits the metastasis of non-small-cell lung cancer in a SUV39H2/LSD1/CDH1-dependent manner	15

Ad5/3 is able to avoid neutralization by binding to erythrocytes and lymphocytes	15
SMURF1, a promoter of tumor cell progression?	15
Mutant KRAS drives metabolic reprogramming and autophagic flux in premalignant pancreatic cells	15
LncRNA MAFG-AS1 promotes the malignant phenotype of ovarian cancer by upregulating NFKB1-dependent IGF1	15
Clinical trials of self-replicating RNA-based cancer vaccines	15
Transcriptional activators YAP/TAZ and AXL orchestrate dedifferentiation, cell fate, and metastasis in human osteosarcoma	14
Recent progress in exosome research: isolation, characterization and clinical applications	14
LncRNA ANCR promotes glioma cells invasion, migration, proliferation and inhibits apoptosis via interacting with EZH2 and repressing PTEN expression	14
METTL3-mediated N6-methyladenosine modification of DUSP5 mRNA promotes gallbladder-cancer progression	14
miR-34c-3p targets CDK1 a synthetic lethality partner of KRAS in non-small cell lung cancer	14
Circular RNA FLNA acts as a sponge of miR-486-3p in promoting lung cancer progression via regulating XRCC1 and CYP1A1	14
LncRNA KCNQ1OT1 regulates the invasion and migration of hepatocellular carcinoma by acting on S1PR1 through miR-149	14
m6A-modified circFOXK2 targets GLUT1 to accelerate oral squamous cell carcinoma aerobic glycolysis	14
YAP 5-methylcytosine modification increases its mRNA stability and promotes the transcription of exosome secretion-related genes in lung adenocarcinoma	14
The LncRNA RP11-301G19.1/miR-582-5p/HMGB2 axis modulates the proliferation and apoptosis of multiple myeloma cancer cells via the PI3K/AKT signalling pathway	13
Decellularized normal and cancer tissues as tools for cancer research	13
Downregulation of SBF2-AS1 functions as a tumor suppressor in clear cell renal cell carcinoma by inhibiting miR-338-3p-targeted ETS1	13
Protein kinase inhibitor responses in uveal melanoma reflects a diminished dependency on PKC-MAPK signaling	13
Viroimmunotherapy for breast cancer: promises, problems and future directions	13
Safety of Adeno-associated virus-based vector-mediated gene therapy—impact of vector dose	13
Enhanced antitumor immune response in melanoma tumor model by anti-PD-1 small interference RNA encapsulated in nanoliposomes	13
CircRNA circ_0006156 inhibits the metastasis of prostate cancer by blocking the ubiquitination of S100A9	13
Tumor suppressor immune gene therapy to reverse immunotherapy resistance	13
Proof of principle study of sequential combination atezolizumab and Vigil in relapsed ovarian cancer	13
m6A demethylase ALKBH5 promotes tumor cell proliferation by destabilizing IGF2BPs target genes and worsens the prognosis of patients with non-small-cell lung cancer	13
LINC00337 promotes tumor angiogenesis in colorectal cancer by recruiting DNMT1, which suppresses the expression of CNN1	13
c-Jun N-terminal kinase 2 suppresses pancreatic cancer growth and invasion and is opposed by c-Jun N-terminal kinase 1	12
Cannabinoids orchestrate cross-talk between cancer cells and endothelial cells in colorectal cancer	12
Inhibition of host Ogr1 enhances effector CD8+ T-cell function by modulating acidic microenvironment	12
Combination of ZEN-3694 with CDK4/6 inhibitors reverses acquired resistance to CDK4/6 inhibitors in ER-positive breast cancer	12
NEAT1 in bone marrow mesenchymal stem cell-derived extracellular vesicles promotes melanoma by inducing M2 macrophage polarization	12
Silencing long noncoding RNA colon cancer-associated transcript-1 upregulates microRNA-34a-5p to promote proliferation and differentiation of osteoblasts in osteoporosis	12
EZH1/2 as targets for cancer therapy	12
Mechanisms of drug resistance mediated by long non-coding RNAs in non-small-cell lung cancer	12
RETRACTED ARTICLE: circ_001504 promotes the development of renal cell carcinoma by sponging microRNA-149 to increase NUCB2	12
Long-term response to autologous anti-CD19 chimeric antigen receptor T cells in relapsed or refractory B cell acute lymphoblastic leukemia: a systematic review and meta-analysis	12
A new immunotherapy strategy targeted CD30 in peripheral T-cell lymphomas: CAR-modified T-cell therapy based on CD30 mAb	12
LncRNA LINC00649 recruits TAF15 and enhances MAPK6 expression to promote the development of lung squamous cell carcinoma via activating MAPK signaling pathway	11
MicroRNA-766-3p-mediated downregulation of HNF4G inhibits proliferation in colorectal cancer cells through the PI3K/AKT pathway	11
Targeting GNAQ/11 through PKC inhibition in uveal melanoma	11
Human umbilical cord blood mesenchymal stem cells-derived exosomal microRNA-503-3p inhibits progression of human endometrial cancer cells through downregulating MEST	11
Molecular mechanism of miR-34b-5p and RNA binding protein HuR binding to lncRNA OIP5-AS1 in colon cancer cells	11
New targeted and epigenetic therapeutic strategies for the treatment of uveal melanoma	11
Exosomal lncRNA HCG18 contributes to cholangiocarcinoma growth and metastasis through mediating miR-424-5p/SOX9 axis through PI3K/AKT pathway	11
Inhibition of Gli2 suppresses tumorigenicity in glioblastoma stem cells derived from a de novo murine brain cancer model	11
DRAIC promotes growth of breast cancer by sponging miR-432-5p to upregulate SLBP	11
LSD1-mediated stabilization of SEPT6 protein activates the TGF-β1 pathway and regulates non-small-cell lung cancer metastasis	11
Downregulation of miR-335 exhibited an oncogenic effect via promoting KDM3A/YAP1 networks in clear cell renal cell carcinoma	11
Cancer immunotherapies revisited: state of the art of conventional treatments and next-generation nanomedicines	11
UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53	11
Pan-cancer methylome analysis for cancer diagnosis and classification of cancer cell of origin	11
DNA-double strand breaks enhance the expression of major histocompatibility complex class II through the ATM-NF-κΒ-IRF1-CIITA pathway	10
CF33-hNIS-antiPDL1 virus primes pancreatic ductal adenocarcinoma for enhanced anti-PD-L1 therapy	10
The application of CRISPR/Cas9 system in cervical carcinogenesis	10
ERK3/MAPK6 is required for KRAS-mediated NSCLC tumorigenesis	10
Centromere protein F promotes progression of hepatocellular carcinoma through ERK and cell cycle-associated pathways	10
Exosomal HMGA2 protein from EBV-positive NPC cells destroys vascular endothelial barriers and induces endothelial-to-mesenchymal transition to promote metastasis	10
Cancer vaccine strategies using self-replicating RNA viral platforms	10
CRISPR/Cas9-mediated knockout of PIM3 suppresses tumorigenesis and cancer cell stemness in human hepatoblastoma cells	10
microRNA-9-5p regulates the mitochondrial function of hepatocellular carcinoma cells through suppressing PDK4	10
Flotillin-1 palmitoylation turnover by APT-1 and ZDHHC-19 promotes cervical cancer progression by suppressing IGF-1 receptor desensitization and proteostasis	10
Overexpressed transient receptor potential vanilloid 1 (TRPV1) in lung adenocarcinoma harbours a new opportunity for therapeutic targeting	10
Long non-coding RNA FOXD3-AS1 silencing exerts tumor suppressive effects in nasopharyngeal carcinoma by downregulating FOXD3 expression via microRNA-185-3p upregulation	10
RETRACTED ARTICLE: microRNA-211-mediated targeting of the INHBA-TGF-β axis suppresses prostate tumor formation and growth	10
Use of an optimised enzyme/prodrug combination for Clostridia directed enzyme prodrug therapy induces a significant growth delay in necrotic tumours	10
The molecular underpinning of geminin-overexpressing triple-negative breast cancer cells homing specifically to lungs	10
The LIN28B/TGF-β/TGFBI feedback loop promotes cell migration and tumour initiation potential in cholangiocarcinoma	10
Combination regimen of granulocyte colony-stimulating factor and recombinant human thrombopoietin improves the curative effect on elderly patients with leukemia through inducing pyroptosis and ferropt	9
Intratumoral DNA-based delivery of checkpoint-inhibiting antibodies and interleukin 12 triggers T cell infiltration and anti-tumor response	9
Understanding and addressing barriers to successful adenovirus-based virotherapy for ovarian cancer	9
CDK4/6-USP51 axis regulates lung adenocarcinoma metastasis through ZEB1	9
Bone marrow stromal cells-derived microRNA-181-containing extracellular vesicles inhibit ovarian cancer cell chemoresistance by downregulating MEST via the Wnt/β-catenin signaling pathway	9
Identification of a five genes prognosis signature for triple-negative breast cancer using multi-omics methods and bioinformatics analysis	9
RETRACTED ARTICLE: Silencing of long non-coding RNA XIST represses gastric cancer progression through blocking NFκB pathway via inhibiting HNF4A-mediated transcription of EPHA1	9
Whole-exome sequencing in eccrine porocarcinoma indicates promising therapeutic strategies	9
RETRACTED ARTICLE: Long non-coding RNA DIO3OS binds to microRNA-130b to restore radiosensitivity in esophageal squamous cell carcinoma by upregulating PAX9	9
Correction: Cancer-associated fibroblasts: overview, progress, challenges, and directions	9
Silencing TRAIP suppresses cell proliferation and migration/invasion of triple negative breast cancer via RB-E2F signaling and EMT	9
Genomic alterations caused by HPV integration in a cohort of Chinese endocervical adenocarcinomas	9
LncSNHG14 promotes nutlin3a resistance by inhibiting ferroptosis via the miR-206 /SLC7A11 axis in osteosarcoma cells	9

Analysis of the mutational status of SIX1/2 and microRNA processing genes in paired primary and relapsed Wilms tumors and association with relapse

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