OOIR: Observatory of International Research

Papers

(The TQCC of Protein and Peptide Letters is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Effects of Glutathionylation on Guanylyltransferase Activity of NS5 N-terminal Capping Domain from Dengue, Japanese Encephalitis, and Zika Viruses	69
Amplification of Amyloid Protein-induced Aggregation of the Eukaryotic Ribosome	44
Structural Shifts of the Parvovirus B19 Capsid Receptor-binding Domain: A Peptide Study	38
FOXN3 Expression Regulated by miR-299-5p Inhibiting the Proliferation, Migration and Invasion of Oral Squamous Cell Carcinoma Cells	28
Understanding Protein Functions in the Biological Context	24
Heat-Shock Triggers Inverted Induction of Hypo-S-Nitrosylation and Hyper-O-GlcNAcylation	20
Acknowledgements to Reviewers	20
Effective Plant-Derived Proteins and Peptides in Leukemia Treatment	19
Molecular Interactions of the Antimicrobial Peptide Tritrpticin with Mixed Nanoaggregates: A Fluorescence Spectroscopy Study	19
Recent Applications of Tissue-Engineered 3D Scaffolds in Oncology: Present and Future Perspectives	18
Hybrid 3D Bioprinted Scaffolds for the Delivery of Peptide Therapeutics	17
Potent Antioxidant and Antibacterial Activities of ≤3 kDa Hydrolyzed Sarcoplasmic Proteins from IPB-D1 Chicken	16
Water-soluble Moringa oleifera Seed Lectin Exhibits Monoaminergic Pathway-linked Anti-depressive-like Effects in Mice	16
Inhibition of Canonical Wnt Signaling in Renal Cell Carcinoma Bone Metastasis: An Immunohistochemical Analysis of DKK1 and LRP5 Expression	15
ZP3 Expression in Pancreatic Adenocarcinoma: Its Implications for the Prognosis and Therapy	15
LINC01836 Promotes Colorectal Cancer Progression and Functions as ceRNA to Target SLC17A9 by Sponging miR-1226-3p	14
Corrigendum to: Reviewing the Context of Molecular Modeling to Enhance the Application of Machine Learning Technologies for Safer Bioinformatics	14
Plasma/Serum Proteomics based on Mass Spectrometry	14
Effect of Adipokinetic Hormone on Learning-Memory in a Scopolamine-Induced Alzheimer's Model in Mice	13
PLEKHG7 Expression: A Biomarker for Prognosis and Targeted Therapy in Diffuse Large B-cell Lymphoma	13
Current Trends and Applications of Food-derived Antihypertensive Peptides for the Management of Cardiovascular Disease	13
An Overview of the Role of Membrane Proteins in Microbial Solvents Tolerance	13
HSP90-regulated CHIP/TRIM21/p21 Axis Involves in the Senescence of Osteosarcoma Cells	13
The Implication of Hypocretin in Drug Abuse and Arousal in the Brain Stem	13
Comprehensive Analysis of lncRNA and mRNA Expression Profile of Macrophage RAW264.7 Stimulated by Antimicrobial Peptide BSN-37	12

Unraveling the Role of Functional Amyloids and Amyloid Peptides in Disease Detection	12
Investigation of Early Growth Response Protein (EGR) Levels in Patients with Fibromyalgia Syndrome: A Cross-Sectional Study	11
Trypsin/α-Amylase Inhibitors from Capsicum chinense Seeds: Characterization and Antifungal Activity against Fungi of Agronomic Importance	11
Variable Surface Antigens of Plasmodium falciparum: Protein Families with Divergent Roles	11
Molecular Bases of Protein Antigenicity and Determinants of Immunogenicity, Anergy, and Mitogenicity	11
SNHG3/miR-330-5p/HSD11B1 Alleviates Myocardial Ischemia-reperfusion Injury by Regulating the ERK/p38 Signaling Pathway	11
A Review of Gap Junction Protein and its Potential Role in Nervous System-Related Disease	11
Protein Tyrosine Phosphatase Receptor-type Q: Structure, Activity, and Implications in Human Disease	11
Binding of l-Anilino-8-Napthalenesulfonate to Free and Coformycin-Complexed Bovine Adenosine Deaminase	10
Association between Higher Expression of Vav1 in Hepatocellular Carcinoma and Unfavourable Clinicopathological Features and Prognosis	10
Synthesis of Two Designed Hairprin Peptides on a Newly Developed 1,6-Hexanediol Diacrylate (HDODA)-Crosslinked Polystyrene Resin	10
Unveiling the Molecular Mechanism of Diosmetin and its Impact on Multifaceted Cellular Signaling Pathways	10
A Review on Recent Advancement in Expression Strategies Used in Bacillus subtilis	9
UPBEAT1-ROS-POD-PAL System under Different Xylogenesis Scenarios in Karelian Birch (Betula pendula Roth var. carelica (Mercl.) Hämet-Ahti)	9
Potassium Channels Contributes to Apelin-induced Vasodilation in Rat Thoracic Aorta	9
Gelsolin Inhibits the Proliferation of Colon Cancer Cells by Enhancing the Expression of TNFR2/CASP10 as a Death Receptor Pathway	9
Neuroprotective Effect of Dexmedetomidine Pretreatment on Sevoflurane- Initiated Neurotoxicity Via the Mir-204-5p/SOX4 Axis	9
Targeting APE1: Advancements in the Diagnosis and Treatment of Tumors	9
Guanidinium-based Integrated Peptide Dendrimers: Pioneer Nanocarrier in Cancer Therapy	9
Improved Soluble Expression in Escherichia coli and Easily Purified Recombinant Human Bone Morphogenetic 7-2 Fusion Protein	9
Neuropeptide Network of Polycystic Ovary Syndrome – A Review	8
Preface	8
Dexmedetomidine Alleviates Brain Ischemia/Reperfusion Injury by Regulating Metastasis-associated Lung Adenocarcinoma Transcript 1/MicroRNA-140-5p/ Nuclear Factor Erythroid-derived 2-like 2 Axis	8
Structural and Functional Analysis of Urease Accessory Protein E from Vancomycin-Resistance Staphylococcus aureus MU50 Strain	7
Screening of MMP-2 Inhibiting Phytoconstituents for the Development of Newer Pancreatic Cancer Treatment Modalities	7
Methods of PARP-1 Determination and its Importance in Living Organisms	7
Insights into Coronavirus Papain-like Protease Structure, Function and Inhibitors	7
Meclofenoxate Inhibits Aggregation of Alpha-synuclein in vitro	7
Thermodynamics of the Association of Aminoglycoside Antibiotics with Human Angiogenin	7
Wogonin Restrains the Malignant Progression of Lung Cancer Through Modulating MMP1 and PI3K/AKT Signaling Pathway	7
Cold-Induced RNA-Binding Protein and RNA-Binding Motif Protein 3: Two RNA Molecular Chaperones Closely Related to Reproductive Development and Reproductive System Diseases	7
Lessons Learnt and the Way Forward for Drug Development Against Isocitrate Lyase from Mycobacterium tuberculosis	7
Preparation of IgE Antibody and Distribution of IgE+ Secretory Cells in the Palatine Tonsil of Bactrian Camel	7
Identifying the Role of Individual Seal IAPP Amino Acids in Inhibiting the Aggregation of Human IAPP	7
Regulatory Mechanism of lncRNA CTBP1-AS2 in Nasopharyngeal Carcinoma Cell Proliferation and Apoptosis via the miR-140-5p/BMP2 Axis	7
Knockdown of Programmed Death 1 Inhibited Progression of Papillary Thyroid Carcinoma in Mice	7
Modified Levels of Renin Angiotensin Related Components in the Frontal Cortex and Hippocampus were Associated with Neuroinflammation and Lower Neuroprotective Effects of NGF During Acute Hepatic Encep	7
P53-induced GAP-43 Upregulation in Primary Cortical Neurons of Rats	7
The LL-37 Antimicrobial Peptide as a Treatment for Systematic Infection of Acinetobacter baumannii in a Mouse Model	6
Purification, Crystallization, and Preliminary X-ray Diffraction Studies on Hemoglobin from the Angora Goat (Capra Aegagrus Hircus)	6
A Functional Human Glycogen Debranching Enzyme Encoded by a Synthetic Gene: Its Implications for Glycogen Storage Disease Type III Management	6
Expression and Purification of His-Tagged Variants of Human Hepatitis A Virus 3C Protease	6
Interaction of the Seed Lectin from Parkia Platycephala (Mimosoideae) with Carbohydrates and Complex Glycans	6
Applications of CRISPR Cas-9 in Ovarian Cancer Research	6
Feasibility of Domain Segmentation of B19V VP1u Using Intein Technology for Structural Studies	6
Development of a Peptide-Based Multiepitope Vaccine from the SARS-CoV-2 Spike Protein for Targeted Immune Response Against COVID-19	6
Design of Artificial C-Peptides as Potential Anti-HIV-1 Inhibitors Based on 6-HB Formation Mechanism	6
Antimicrobial Peptides: An Overview of their Structure, Function and Mechanism of Action	6
Combining Network Pharmacology, Molecular Docking and Preliminary Experiments to Explore the Mechanism of Action of FZKA Formula on Non-small Cell Lung Cancer	6
Unidentified N-glycans by N-glycosidase A were Identified by Nglycosidase F under Denaturing Conditions in Plant Glycoprotein	6

Characterization of a Novel Thermostable 7α-Hydroxysteroid Dehydrogenase	6
Comparison of Adjuvant Effects of Montanide ISA-720 and Heat Shock Protein 27 in Increasing Immunostimulatory Properties of HIV-1 Nef-Vif Fusion Protein Construct	6
The Agonistic Activity of the Human Epidermal Growth Factor is Reduced by the D46G Substitution	6
Proteomic Analysis of Glucose-Induced Cardiac Myoblasts and the Potential Role of mir-92b-5p in Regulating Sarcomere Proteins Under a Hyperglycemic Environment	6
Some Minor Characteristics of Spectrophotometric Determination of Antioxidant System and Phenolic Metabolism Enzyme Activity in Wood Plant Tissues of Pinus sylvestris L.	5
Advances in Polymeric Drug Delivery Systems: From Biodegradability to Nanocarrier Technologies	5
Precision Enzyme: Targeted Drug Discovery in Neurodegenerative Disorders	5
Cyclopeptide-based Anti-liver Cancer Agents: A Mini-review	5
Optimizing Sleep in Athletes: The Potential of α-Lactalbumin in Nutrition Intervention	5
Design, Expression, and Purification of a Fusion Enzyme Containing Terminal Deoxynucleotidyl Transferase from B. bovis and DNA-Binding Proteins from E. coli	5
Circ_0008768 Suppresses the Pancreatic Cancer Progression via miR-330- 3p/PTEN Axis	5
Estrogen Sulfotransferase SULT1E1 Expression Levels and Regulated Factors in Malignant Tumours	5
Production of Soluble Murine TRAILs in Escherichia coli with Zn²⁺ Supplementation	5
Concentration-mediated Folding and Unfolding of Collagen Triple Helix	5
In Silico Analysis of Natural Plant-Derived Cyclotides with Antifungal Activity against Pathogenic Fungi	5
Participation of CWINV and SUS Genes in Sucrose Utilization in the Disruption of Cambium Derivatives Differentiation of Silver Birch	5
Design, Synthesis and DNA-Binding Activities of GCN4 Peptide Dimer Studied by Circular Dichroism Spectroscopy	5
Exploring the Potential Long-term Impact of SARS-CoV-2 on Protein Misfolding and Amyloid-related Conditions	5
Analysis of the Interaction of UBE2Q1 with B4GALT1 and P53: Experimental and Molecular Modeling Study	5
Biocompatible Excipients from Microalgae: Advancing Protein and Peptide Therapeutics through Sustainable Formulation Strategies	5
Disruption of Staphylococcus aureus Biofilms with Purified Moringa oleifera Leaf Extract Protein	5
The Roles of Ciliary Neurotrophic Factor - from Neuronutrition to Energy Metabolism	5
Proteome-Wide Acetylome Profiling Suggests Extensive Aspirin-Driven Remodeling of Networks Relevant to THP-1 Macrophage Differentiation	5
Natural Amphibian-Derived Host Defense Peptides: Peptide Immunomodulators with Potential Therapeutic Value	5
Unlocking the Keratinolytic Potential of Brevibacillus agri Derived Keratinase: A Molecular Characterization Study	5
Biochemical Aspects of the Spiral Grain Formation in Scots Pine (Pinus Sylvestris L.) Wood. Some Differences and Similarities with Biochemical Indicators of Abnormal Xylogenesis in Karelian Birch (Bet	5
Expression, Purification, and Evaluation of Antibody Responses and Antibody-Immunogen Complex Simulation of a Designed Multi-Epitope Vaccine against SARS-COV-2	5
MicroRNA-605-3p Inhibited the Growth and Chemoresistance of Osteosarcoma Cells via Negatively Modulating RAF1	5