Current Medicinal Chemistry

Papers
(The TQCC of Current Medicinal Chemistry is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)
ArticleCitations
SARS-CoV-2: Recent Reports on Antiviral Therapies Based on Lopinavir/Ritonavir, Darunavir/Umifenovir, Hydroxychloroquine, Remdesivir, Favipiravir and other Drugs for the Treatment of the New Coronavir215
Metal-Organic Framework (MOF)-Based Drug Delivery162
Zeolitic Imidazolate Frameworks (ZIF-8) for Biomedical Applications: A Review129
Recent Research on Flavonoids and their Biomedical Applications129
Antimicrobial Capacity of Plant Polyphenols against Gram-positive Bacteria: A Comprehensive Review109
Osteoporosis: Mechanism, Molecular Target and Current Status on Drug Development101
Comprehensive Review on Graphene Oxide for Use in Drug Delivery System91
Recent Progress in Histone Deacetylase Inhibitors as Anticancer Agents83
The Role of Zinc and Copper in Insulin Resistance and Diabetes Mellitus79
Natural Polymer-based Stimuli-responsive Hydrogels78
Acyclovir in the Treatment of Herpes Viruses – A Review75
The Role of Diet Related Short-Chain Fatty Acids in Colorectal Cancer Metabolism and Survival: Prevention and Therapeutic Implications72
Ferroptosis: A Novel Mechanism of Artemisinin and its Derivatives in Cancer Therapy66
The Application of Hydrogels Based on Natural Polymers for Tissue Engineering58
The Role of Tumor Associated Macrophages (TAMs) in Cancer Progression, Chemoresistance, Angiogenesis and Metastasis - Current Status57
The “Big Five” Phytochemicals Targeting Cancer Stem Cells: Curcumin, EGCG, Sulforaphane, Resveratrol and Genistein55
Natural Polymers Based Hydrogels for Cell Culture Applications55
Targeting n-3 Polyunsaturated Fatty Acids in Non-Alcoholic Fatty Liver Disease52
Cyclosporine A: Chemistry and Toxicity – A Review51
Advances in Pharmacological Activities and Mechanisms of Glycyrrhizic Acid50
FTY720 (Fingolimod) Ameliorates Brain Injury through Multiple Mechanisms and is a Strong Candidate for Stroke Treatment49
B7-H3 Immune Checkpoint Protein in Human Cancer49
Natural COX-2 Inhibitors as Promising Anti-inflammatory Agents: An Update49
A Comprehensive Review on Oxysterols and Related Diseases46
Exosomes and Lung Cancer: Roles in Pathophysiology, Diagnosis and Therapeutic Applications46
Deep Learning in Drug Target Interaction Prediction: Current and Future Perspectives46
Anti-Coronavirus Vaccines: Past Investigations on SARS-CoV-1 and MERS-CoV, the Approved Vaccines from BioNTech/Pfizer, Moderna, Oxford/AstraZeneca and others under Development Against SARSCoV- 2 Infec45
Osteoporosis: Current and Emerging Therapies Targeted to Immunological Checkpoints44
Anti-tumor Effects of Curcuminoids in Glioblastoma Multiforme: An Updated Literature Review44
Central Regulatory Role of Cytokines in Periodontitis and Targeting Options43
Obesity and Insulin Resistance: Associations with Chronic Inflammation, Genetic and Epigenetic Factors42
Recent Progress of Benzimidazole Hybrids for Anticancer Potential41
Structural Basis of Drug Recognition by Human Serum Albumin40
Metal Toxicity and Speciation: A Review39
Terpenes, Phenylpropanoids, Sulfur and Other Essential Oil Constituents as Inhibitors of Cholinesterases39
Indole Derivatives as Anti-Tubercular Agents: An Overview on their Synthesis and Biological Activities35
Nanoparticles in Combating Cancer: Opportunities and Limitations: A Brief Review35
Relationship between Gut Microbiota, Gut Hyperpermeability and Obesity34
Metal Complexes as Promising Agents for Biomedical Applications34
Recent Advances in Elucidating Paclitaxel Resistance Mechanisms in Non-small Cell Lung Cancer and Strategies to Overcome Drug Resistance33
Lipids as Activators of Innate Immunity in Peptide Vaccine Delivery33
Natural Anti-inflammatory Compounds as Drug Candidates in Alzheimer’s Disease33
New Aspects of Monoamine Oxidase B Inhibitors: The Key Role of Halogens to Open the Golden Door32
Tubulin Inhibitors Binding to Colchicine-Site: A Review from 2015 to 201932
New Perspectives in the Pharmacological Potential of Naringin in Medicine32
Targeting the JAK/STAT Signaling Pathway for Breast Cancer32
Cordycepin as a Promising Inhibitor of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp)31
Lipid-Lowering Therapies for Atherosclerosis: Statins, Fibrates, Ezetimibe and PCSK9 Monoclonal Antibodies31
Recent Advances in Fe-MOF Compositions for Biomedical Applications31
Monoamine Oxidase-B (MAO-B) Inhibitors in the Treatment of Alzheimer’s and Parkinson’s Disease31
Natural Products as Potential Anti-Alzheimer Agents30
1-Deoxynojirimycin and its Derivatives: A Mini Review of the Literature29
Machine Learning Approaches in Parkinson’s Disease29
LncRNAs: Potential Novel Prognostic and Diagnostic Biomarkers in Colorectal Cancer29
A critical transcription factor NF-κB as a cancer therapeutic target and its inhibitors as cancer treatment options29
Chitosan-Nanocellulose Composites for Regenerative Medicine Applications29
The Role of Plant-Derived Compounds in Managing Diabetes Mellitus: A Review of Literature from 2014 To 201929
Nerve Growth Factor, Stress and Diseases29
Selective MMP-13 Inhibitors: Promising Agents for the Therapy of Osteoarthritis28
Neuronal Development-Related miRNAs as Biomarkers for Alzheimer's Disease, Depression, Schizophrenia and Ionizing Radiation Exposure28
Survey of Similarity-Based Prediction of Drug-Protein Interactions28
The Nitric Oxide Pathway in Pulmonary Arterial Hypertension: Pathomechanism, Biomarkers and Drug Targets28
Anti-angiogenic Agents: A Review on Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) Inhibitors28
The Role of Mitochondria in Systemic Lupus Erythematosus: A Glimpse of Various Pathogenetic Mechanisms28
Exosome-like Nanoparticles: A New Type of Nanocarrier27
Formulation and Application of Nanoemulsions for Nutraceuticals and Phytochemicals27
Inflammation, Oxidative Stress, Vascular Aging and Atherosclerotic Ischemic Stroke26
Small Molecular Gemcitabine Prodrugs for Cancer Therapy26
Romidepsin (FK228), A Histone Deacetylase Inhibitor and its Analogues in Cancer Chemotherapy26
Protective Role of Natural Products in Glioblastoma Multiforme: A Focus on Nitric Oxide Pathway26
203/212Pb Theranostic Radiopharmaceuticals for Image-guided Radionuclide Therapy for Cancer25
Small-Molecule CSF1R Inhibitors as Anticancer Agents25
Recent Advances in Multi-target Drugs Targeting Protein Kinases and Histone Deacetylases in Cancer Therapy25
Neutrophil/Lymphocyte, Platelet/Lymphocyte, and Monocyte/Lymphocyte Ratios in Mood Disorders25
Evidence of Protein Binding by a Nucleopeptide Based on a Thyminedecorated L-Diaminopropanoic Acid through CD and In Silico Studies25
Chlorogenic Acid: A Dietary Phenolic Acid with Promising Pharmacotherapeutic Potential25
Translational Theragnosis of Ovarian Cancer: where do we stand?25
Metabolic Reprogramming of Cancer by Chemicals that Target Glutaminase Isoenzymes25
Discovery and Development of the Oral Complement Factor D Inhibitor Danicopan (ACH-4471)24
Another Look at Dietary Polyphenols: Challenges in Cancer Prevention and Treatment24
Sulfur-containing Secondary Metabolites as Neuroprotective Agents24
Protective Effects of Curcumin against Lipopolysaccharide-Induced Toxicity24
Recent Advances and Challenges of the Drugs Acting on Monoamine Transporters24
Microbiota, Immune System and Autism Spectrum Disorders: An Integrative Model towards Novel Treatment Options24
Copper Concentrations in Breast Cancer: A Systematic Review and Meta-Analysis23
Role of Resveratrol in Modulating microRNAs in Human Diseases: From Cancer to Inflammatory Disorder23
Diffuse Intrinsic Pontine Glioma (DIPG): Breakthrough and Clinical Perspective23
Drug Repurposing: A Strategy for Discovering Inhibitors against Emerging Viral Infections23
Dietary Epicatechin, A Novel Anti-aging Bioactive Small Molecule23
Recent Advances in the Rational Drug Design Based on Multi-target Ligands23
Biotechnological Potential of Streptomyces Siderophores as New Antibiotics23
Perspectives on Drug Repurposing23
Gonadotropin-Releasing Hormone and GnRH Receptor: Structure, Function and Drug Development23
Role of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Different Disease States: Recent Updates23
Exosome-Mediated Drug Delivery for Cell-Free Therapy of Osteoarthritis23
Histone Modifications and their Role in Epigenetics of Cancer23
Copper Complexes as Antitumor Agents:In vitroandIn vivoEvidence23
Genotype Driven Therapy for Non-Small Cell Lung Cancer: Resistance, Pan Inhibitors and Immunotherapy23
Nanocarrier-based Drug Delivery System for Cancer Therapeutics: A Review of the Last Decade23
The Emerging Roles of Exosomes in the Chemoresistance of Hepatocellular Carcinoma22
A comparative analysis on different enzyme immobilization nanomaterials: Progress, constraints, and recent trends22
Resveratrol and Prostate Cancer: The Power of Phytochemicals22
Effects of Pterostilbene on Diabetes, Liver Steatosis and Serum Lipids22
Biofilm Formation as Valuable Target to Fight against Severe Chronic Infections22
Engineered Exosomes: A Promising Drug Delivery Strategy for Brain Diseases22
Mediterranean Diet, Brain and Muscle: Olive Polyphenols and Resveratrol Protection in Neurodegenerative and Neuromuscular Disorders22
Recent Advances in Asialoglycoprotein Receptor and Glycyrrhetinic Acid Receptor-Mediated and/or pH-Responsive Hepatocellular Carcinoma- Targeted Drug Delivery22
Synthesis and Antioxidant Properties of Organoselenium Compounds22
Monoclonal Antibodies Carried in Drug Delivery Nanosystems as a Strategy for Cancer Treatment22
Tryptophan Metabolism in Atherosclerosis and Diabetes21
Current Scenario and Future Prospect in the Management of COVID-1921
Clinical and Translational Research Challenges in Biliary Tract Cancers21
Stimuli-responsive Drug Delivery Nanocarriers in the Treatment of Breast Cancer21
The CXCL12-CXCR4 Signaling Axis Plays a Key Role in Cancer Metastasis and is a Potential Target for Developing Novel Therapeutics against Metastatic Cancer21
Targeting Mammalian Target of Rapamycin: Prospects for the Treatment of Inflammatory Bowel Diseases21
Natural Product Inhibitors of Cyclooxygenase (COX) Enzyme: A Review on Current Status and Future Perspectives21
The Roles of Programmed Cell Death Ligand-1/ Programmed Cell Death-1 (PD-L1/PD-1) in HPV-induced Cervical Cancer and Potential for their Use in Blockade Therapy20
The Healing Effects of Spices in Chronic Diseases20
OX40 and OX40L Interaction in Cancer20
Mechanistic Insights of Soluble Uric Acid-related Kidney Disease20
Role of Alpha-Fetoprotein in Hepatocellular Carcinoma Drug Resistance20
Artificial Intelligence as a Business Partner in Cardiovascular Precision Medicine: An Emerging Approach for Disease Detection and Treatment Optimization20
The Role of Endothelial Related Circulating Biomarkers in COVID-19. A Systematic Review and Meta-analysis19
A Comprehensive Overview of Colon Cancer- A Grim Reaper of the 21st Century19
Dysfunctional High-density Lipoprotein: The Role of Myeloperoxidase and Paraoxonase-119
Cardioprotective Properties of HDL: Structural and Functional Considerations19
Mitochondria-Associated Membranes (MAMs): A Novel Therapeutic Target for Treating Metabolic Syndrome19
Histone Deacetylases (HDACs) in Gastric Cancer: An Update of their Emerging Prognostic and Therapeutic Role19
Application of Machine Learning Techniques to Predict Binding Affinity for Drug Targets: A Study of Cyclin-Dependent Kinase 219
Applications of Micro/Nanotechnology in Ultrasound-based Drug Delivery and Therapy for Tumor19
Molecular Mechanism of the Canonical Oncogenic lncRNA MALAT1 in Gastric Cancer19
Curcumin: A Dietary Phytochemical for Targeting the Phenotype and Function of Dendritic Cells19
Flavonoids and PI3K/Akt/mTOR Signaling Cascade: A Potential Crosstalk in Anticancer Treatment19
Enalos Suite of Tools: Enhancing Cheminformatics and Nanoinfor - matics through KNIME19
Recent Advances in c-Jun N-Terminal Kinase (JNK) Inhibitors19
LPS/TLR4 Pathways in Breast Cancer: Insights into Cell Signalling18
Functional Chitosan-based Materials for Biological Applications18
The Chronicle of COVID-19 and Possible Strategies to Curb the Pandemic18
Ferroptosis: A Trusted Ally in Combating Drug Resistance in Cancer18
Biomedical Applications of Hemicellulose-Based Hydrogels18
High-Intensity Focused Ultrasound in the Treatment of Breast Cancer18
Indole and Indoline Scaffolds in Antimicrobials: Overview, Synthesis and Recent Advances in Antimicrobial Research18
Recent Progress in Polynuclear Ruthenium Complex-Based DNA Binders/Structural Probes and Anticancer Agents18
Secondary Metabolites from Deep-Sea Derived Microorganisms18
Review—Recent Advancements in Electrochemical Biosensors for Alzheimer’s Disease Biomarkers Detection18
A2A Adenosine Receptor Antagonists in Neurodegenerative Diseases18
Hydrogels based on Natural Polymers for Medicinal Applications18
Recent Advances in the Development of Casein Kinase 1 Inhibitors18
Neutrophils as Sentinel Cells of the Immune System: A Role of the MPO-halide-system in Innate and Adaptive Immunity18
Cellulose Nanofibrils-based Hydrogels for Biomedical Applications: Progresses and Challenges18
Risk Factors, Mechanisms and Treatments of Thromboangiitis Obliterans: An Overview of Recent Research18
Repurposing of Acriflavine to Target Chronic Myeloid Leukemia Treatment18
Cholecystokinin-2 Receptor Targeting with Radiolabeled Peptides: Current Status and Future Directions17
Advances in Polyaniline for Biomedical Applications17
Molecular Markers of Regulatory T Cells in Cancer Immunotherapy with Special Focus on Acute Myeloid Leukemia (AML) - A Systematic Review17
Quaternized Chitosan Nanoparticles in Vaccine Applications17
Ultrasound-Based Drug Delivery System17
Nanomedicine-Combined Immunotherapy for Cancer17
The Beneficial Hemodynamic Actions of SGLT-2 Inhibitors beyond the Management of Hyperglycemia17
Impact of Epigenetic Alterations in the Development of Oral Diseases17
Metabolic and Amino Acid Alterations of the Tumor Microenvironment17
Antimalarial Drug Discovery: From Quinine to the Most Recent Promising Clinical Drug Candidates17
Immunoconjugates for Cancer Targeting: A Review of Antibody-Drug Conjugates and Antibody-Functionalized Nanoparticles17
Cubilin, the Intrinsic Factor-Vitamin B12 Receptor in Development and Disease17
Formulating SLN and NLC as Innovative Drug Delivery Systems for Non-Invasive Routes of Drug Administration17
Alport Syndrome: A Comprehensive Review on Genetics, Pathophysiology, Histology, Clinical and Therapeutic Perspectives17
Fluorine-Containing Inhalation Anesthetics: Chemistry, Properties and Pharmacology17
Cellulose-based Biosensor for Bio-molecules Detection in Medical Diagnosis: A Mini-Review16
A Systematic Review of the Anti-inflammatory Effects of Gallium Compounds16
Recent Design and Structure-Activity Relationship Studies on the Modifications of DHFR Inhibitors as Anticancer Agents16
Recent Progress on the Discovery of NLRP3 Inhibitors and their Therapeutic Potential16
Self-assembling Peptides in Current Nanomedicine: Versatile Nanomaterials for Drug Delivery16
Drug Repurposing: Promises of Edaravone Target Drug in Traumatic Brain Injury16
Nanotechnology-based Drug Delivery Systems as Potential for Skin Application: A Review16
Recent Trends in Tubulin-Binding Combretastatin A-4 Analogs for Anticancer Drug Development16
Recent Advances of Chitosan and its Derivatives in Biomedical Applications16
HuR as Therapeutic Target in Cancer: What the Future Holds16
Competing Endogenous RNAs (CeRNAs): Novel Network in Neurological Disorders16
Neurokinin-1 Receptor (NK-1R) Antagonists: Potential Targets in the Treatment of Glioblastoma Multiforme16
Mitochondria Associated Membranes (MAMs): Emerging Drug Targets for Diabetes16
The Association between Depression and Gastroesophageal Reflux based on Phylogenetic Analysis of miRNA Biomarkers16
Dual-target Inhibitors Based on BRD4: Novel Therapeutic Approaches for Cancer16
Use of Exogenous Enzymes in Human Therapy: Approved Drugs and Potential Applications16
Resveratrol, a Molecule with Anti-Inflammatory and Anti-Cancer Activities: Natural Product to Chemical Synthesis16
Trefoil Factor Family (TFF) Peptides and their Different Roles in the Mucosal Innate Immune Defense and More: An Update16
Long-Term Accumulation of Metals in the Skeleton as Related to Osteoporotic Derangements16
In Vitro Data of Current Therapies for SARS-CoV-216
Nitric Oxide and Immune Responses in Cancer: Searching for New Therapeutic Strategies16
Role of Fatty Acid Binding Protein 4 (FABP4) in Kidney Disease16
Research Progress in Predicting DNA Methylation Modifications and the Relation with Human Diseases16
Falcipain-2 and Falcipain-3 Inhibitors as Promising Antimalarial Agents15
The Effect of Oxidative Stress and Antioxidant Therapies on Pancreatic β-cell Dysfunction: Results from in Vitro and in Vivo Studies15
Targeting Inflammatory Mediators: An Anticancer Mechanism of Thymoquinone Action15
Critical Review on the Chemical Aspects of Cannabidiol (CBD) and Harmonization of Computational Bioactivity Data15
p53: An Attractive Therapeutic Target for Cancer15
Metformin: A Growing Journey from Glycemic Control to the Treatment of Alzheimer’s Disease and Depression15
Structure and Function of Angiopoietin-like Protein 3 (ANGPTL3) in Atherosclerosis15
Recent Multi-target Approaches on the Development of Anti- Alzheimer's Agents Integrating Metal Chelation Activity15
Nanoparticle-plasma Membrane Interactions: Thermodynamics, Toxicity and Cellular Response15
Tanshinones: An Update in the Medicinal Chemistry in Recent 5 Years15
Azole Derivatives: Recent Advances as Potent Antibacterial and Antifungal Agents15
Recent Advances in Combretastatin A-4 Inspired Inhibitors of Tubulin Polymerization: An Update15
Insights into the Design of Inhibitors of the Urease Enzyme - A Major Target for the Treatment of Helicobacter pylori Infections15
Development of Pin1 Inhibitors and their Potential as Therapeutic Agents15
Electrostatic Potential Energy in Protein-Drug Complexes15
Structure-based Virtual Screening, Molecular Docking, Molecular Dynamics Simulation, and Metabolic Reactivity Studies of Quinazoline Derivatives for their Anti-EGFR Activity Against Tumor Angiogenesis15
The Therapeutic use of the Zonulin Inhibitor AT-1001 (Larazotide) for a Variety of Acute and Chronic Inflammatory Diseases15
Metabolic Remodeling Induced by Adipocytes: A New Achilles' Heel in Invasive Breast Cancer?15
Neuropharmacology of Organoselenium Compounds in Mental Disorders and Degenerative Diseases15
Allosteric Inhibitors of SHP2: An Updated Patent Review (2015-2020)14
Potential Benefits of Phytochemicals for Abdominal Aortic Aneurysm14
Small Molecule Inhibitors Targeting Key Proteins in the DNA Damage Response for Cancer Therapy14
Preparation and Applications of Superparamagnetic Iron Oxide Nanoparticles in Novel Drug Delivery Systems: An Overview14
Advances in Biomedical Application of Nanocellulose-Based Materials: A Review14
Recent Advances in the Development of Broad-Spectrum Antiprotozoal Agents14
Glycogen Synthase Kinase 3β Involvement in Neuroinflammation and Neurodegenerative Diseases14
Diagnoses of Pathological States Based on Acetylcholinesterase and Butyrylcholinesterase14
Ligand- and Structure-Based Drug Design and Optimization using KNIME14
Enzyme Replacement Therapy for Genetic Disorders Associated with Enzyme Deficiency14
Cucurbitacins and the Immune System: Update in Research on Anti- inflammatory, Antioxidant, and Immunomodulatory Mechanisms14
Structure and Function of L,D- and D,D-Transpeptidase Family Enzymes from Mycobacterium tuberculosis14
Roles of Interferon Induced Protein with Tetratricopeptide Repeats (IFIT) Family in Cancer14
Discovery of Anticancer Agents from 2-Pyrazoline-Based Compounds14
Targeting the NLRP3 Inflammasome in Diabetic Nephropathy14
Regulation of Apolipoprotein B by Natural Products and Nutraceuticals: A Comprehensive Review14
mTOR Targeted Cancer Chemoprevention by Flavonoids14
Histone Deacetylases and their Inhibitors in Colorectal Cancer Therapy: Current Evidence and Future Considerations14
Endometrial Cancer: Genetic, Metabolic Characteristics, Therapeutic Strategies and Nanomedicine14
Biochemical Markers in the Prediction of Contrast-induced Acute Kidney Injury14
Natural Sourced Inhibitors of EGFR, PDGFR, FGFR and VEGFRMediated Signaling Pathways as Potential Anticancer Agents14
Therapeutic Aptamers: Evolving to Find their Clinical Niche14
Dehydrocholesterol Reductase 24 (DHCR24): Medicinal Chemistry, Pharmacology and Novel Therapeutic Options14
Gut Microbiota and Cardiovascular Disease: Symbiosis Versus Dysbiosis13
Overview of PROTACs Targeting the Estrogen Receptor: Achievements for Biological and Drug Discovery13
Multi-Target-Directed Ligands as an Effective Strategy for the Treatment of Alzheimer’s Disease13
GABA System in Depression: Impact on Pathophysiology and Psychopharmacology13
Natural Products for the Treatment of Neurodegenerative Diseases13
Beneficial Effects of Dietary Polyphenols in the Prevention and Treatment of NAFLD: Cell-Signaling Pathways Underlying Health Effects13
An Updated Review of the Cross-talk Between MicroRNAs and Epigenetic Factors in Cancers13
Biomedical Applications of Bacterial Cellulose based Composite Hydrogels13
The Effect of CB1 Antagonism on Hepatic Oxidative/Nitrosative Stress and Inflammation in Nonalcoholic Fatty Liver Disease13
Commentary on “Peptide-Conjugated Nanoparticles as Targeted Anti-angiogenesis Therapeutic and Diagnostic in Cancer” by Shaker A. Mousa, Pharmaceutical Research Institute, Albany College of Pharmacy an13
Natural Products as a Promising Therapeutic Strategy to Target Cancer Stem Cells13
Cancer Treatments Using Low-Temperature Plasma13
C1-Inhibitor: Structure, Functional Diversity and Therapeutic Development13
The Role of Interleukin-6 in the Pathogenesis, Prognosis and Treatment of Severe COVID-1913
Natural-based Hydrogels: A Journey from Simple to Smart Networks for Medical Examination13
The Correlation between Lipid Metabolism Disorders and Prostate Cancer13
Pharmacologically Active Vanadium Species: Distribution in Biological Media and Interaction with Molecular Targets13
Microbiome in Critical Care: An Unconventional and Unknown Ally13
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