Amino Acids

Article	Citations
In silico and in vivo neuropharmacological evaluation of two γ-amino acid isomers derived from 2,3-disubstituted benzofurans, as ligands of GluN1–GluN2A NMDA receptor	87
Reply to homocysteine and copper ions: is their interaction responsible for cardiovascular‑related damage?	80
Dietary L-arginine supplementation during days 14–25 of gestation enhances aquaporin expression in the placentae and endometria of gestating gilts	70
Association between dietary essential amino acids intake and metabolic biomarkers: influence of obesity among Chinese children and adolescents	59
Glycine protects against doxorubicin-induced heart toxicity in mice	58
Taurine suppresses liquid–liquid phase separation of lysozyme protein	58
PepAnalyzer: predicting peptide properties using its sequence	57
Acetyl group for proper protection of β-sugar-amino acids used in SPPS	53
Phenolic compounds as potential adenosine deaminase inhibitors: molecular docking and dynamics simulation coupled with MM-GBSA calculations	51
Mucosal-associated invariant T cells display both pathogenic and protective roles in patients with inflammatory bowel diseases	44
Methionine supplementation spares body protein by regulating the expression of mTORC1 downstream factors in rats fed a soy protein diet with sufficient sulfur amino acids: a pilot study	41
Combined charge and hydrophobicity-guided screening of antibacterial peptides: two-level approach to predict antibacterial activity and efficacy	41
BamA-targeted antimicrobial peptide design for enhanced efficacy and reduced toxicity	39
Bromelain and ficin proteolytic effects on gliadin cytotoxicity and expression of genes involved in cell-tight junctions in Caco-2 cells	37
Plasma free amino acid profiles are associated with serum high molecular weight adiponectin levels in Japanese medical check-up population without type 2 diabetes mellitus	36
Sodium pyruvate improves the plasma amino acid profile in rats with l-arginine-induced acute pancreatitis	35
PepTraq: a toolbox for in silico data mining and fast sequence filtering	32
Impact of chemical modifications on the antimicrobial and hemolytic activity of helical amphipathic peptide Lasioglossin LL-III	28
Biochemical and in silico molecular study of caffeic acid-O-methyltransferase enzyme associated with lignin deposition in tall fescue	28
The renoprotective effects of taurine against diabetic nephropathy via the p38 MAPK and TGF-β/Smad2/3 signaling pathways	28
Participation of protein metabolism in cancer progression and its potential targeting for the management of cancer	25
Advanced glycation end products promote the progression of chronic kidney diseases by targeting calpain 6	24
N-Acetyl-L-cysteine in human rheumatoid arthritis and its effects on nitric oxide (NO) and malondialdehyde (MDA): analytical and clinical considerations	24
Effects of l-ascorbic acid (C6H8O6: Vit-C) on collagen amino acids: DFT study	23
Molecular binding mechanism and novel antidiabetic and anti-hypertensive bioactive peptides from fermented camel milk with anti-inflammatory activity in raw macrophages cell lines	23

L-valine production in Corynebacterium glutamicum based on systematic metabolic engineering: progress and prospects	23
Serum amino acid profiles in patients with myasthenia gravis	22
Detection of impurities in dietary supplements containing l-tryptophan	22
Oral anserine supplementation does not attenuate type-2 diabetes or diabetic nephropathy in BTBR ob/ob mice	22
Proline oxidase silencing inhibits p53-dependent apoptosis in MCF-7 breast cancer cells	21
Human cell receptors: potential drug targets to combat COVID-19	21
Cortisol enhances citrulline synthesis from proline in enterocytes of suckling piglets	20
Antimicrobial peptidomes of Bothrops atrox and Bothrops jararacussu snake venoms	20
Functional roles of polyamines and their metabolite acrolein in eukaryotic cells	19
Carnosine and skeletal muscle dysfunction in a rodent multiple sclerosis model	19
Serum and urinary carnosinase-1 correlate with kidney function and inflammation	19
Identification of bacterial lipo-amino acids: origin of regenerated fatty acid carboxylate from dissociation of lipo-glutamate anion	19
Cholesterol-lowering effects of taurine through the reduction of ileal FXR signaling due to the alteration of ileal bile acid composition	19
Development and validation of multiple machine learning algorithms for the classification of G-protein-coupled receptors using molecular evolution model-based feature extraction strategy	19
Branched-chain amino acids regulate intracellular protein turnover in porcine mammary epithelial cells	18
Perspectives, past, present and future: the proline cycle/proline-collagen regulatory axis	18
Using the dual isotope method to assess cecal amino acid absorption of goat whey protein in rats, a pilot study	18
Fibroblast growth factor 9 attenuates sepsis-induced fulminant hepatitis in mice	18
ATGPred-FL: sequence-based prediction of autophagy proteins with feature representation learning	18
Cul5 mediates taurine-stimulated mTOR mRNA expression and proliferation of mouse mammary epithelial cells	18
l-Arginine increases AMPK phosphorylation and the oxidation of energy substrates in hepatocytes, skeletal muscle cells, and adipocytes	17
Effects of maternal branched-chain amino acid and alanine supplementation on growth and biomarkers of protein metabolism in dams fed a low-protein diet and their offspring	17
Dietary L-arginine supplementation increases the hepatic expression of AMP-activated protein kinase in rats	17
Amino acids, post-translational modifications, nitric oxide, and oxidative stress in serum and urine of long COVID and ex COVID human subjects	16
A mutation in the S6 segment of the KvAP channel changes the secondary structure and alters ion channel activity in a lipid bilayer membrane	16
Identification of a peptide that crosses the blood-cerebrospinal fluid barrier by phage display technology	15
Antineoplastic activity of plant-derived compounds mediated through inhibition of histone deacetylase: a review	15
A new 68Ga-labeled ornithine derivative for PET imaging of ornithine metabolism in tumors	15
Glycine regulates mucosal immunity and the intestinal microbial composition in weaned piglets	15
How does neurokinin 3 receptor agonism affect pathological and cognitive impairments in an Alzheimer’s disease-like rat model?	15
Screening of AS101 analog, organotellurolate (IV) compound 2 for its in vitro biocompatibility, anticancer, and antibacterial activities	15
Proline metabolism and redox; maintaining a balance in health and disease	14
Multiple sclerosis and myelin basic protein: insights into protein disorder and disease	14
Development, validation of a GC–MS method for the simultaneous measurement of amino acids, their PTM metabolites and AGEs in human urine, and application to the bi-ethnic ASOS study with special empha	14
Amino acid-stimulated insulin secretion: a path forward in type 2 diabetes	14
The ovine conceptus utilizes extracellular serine, glucose, and fructose to generate formate via the one carbon metabolism pathway	14
Potential of milk-derived bioactive peptides as antidiabetic, antihypertensive, and xanthine oxidase inhibitors: a comprehensive bibliometric analysis and updated review	14
Estimation of bioactive peptide content of milk from different species using an in silico method	14
Synthesis and screening for anticancer activity of two novel telluro-amino acids: 1,3-Tellurazolidine-4-carboxylic acid and tellurohomocystine	14
Methylmalonic acid induces inflammatory response and redox homeostasis disruption in C6 astroglial cells: potential glioprotective roles of melatonin and resveratrol	13
Antidiabetic activity of Tartary buckwheat protein-derived peptide AFYRW and its effects on protein glycosylation of pancreas in mice	13
Hydroxyproline in animal metabolism, nutrition, and cell signaling	12
Dietary leucine requirement of fingerling Channa punctatus (Bloch) based on growth, feed conversion and leucine retention efficiency, hematological parameters, antioxidant and intestinal enzyme activi	12
Pancreastatin inhibitor PSTi8 ameliorates insulin resistance by decreasing fat accumulation and oxidative stress in high-fat diet-fed mice	12
Chromogranin A-derived peptides pancreastatin and catestatin: emerging therapeutic target for diabetes	12
Branched-chain amino acid supplementation does not enhance lean tissue accretion in low birth weight neonatal pigs, despite lower Sestrin2 expression in skeletal muscle	12
Molecular targets for antifungals in amino acid and protein biosynthetic pathways	12
d-Amino acid recognition of tripeptides studied by ultraviolet photodissociation spectroscopy of hydrogen-bonded clusters	12
Analysis of protonation equilibria of some alanyl dipeptides in water and aqueous ethanol mixtures	12
Subchronic tolerance trials of graded oral supplementation with ornithine hydrochloride or citrulline in healthy adults	11

Common alterations in plasma free amino acid profiles and gut microbiota-derived tryptophan metabolites of five types of cancer patients	11
Investigating molecular interactions between human transferrin and resveratrol through a unified experimental and computational approach: Role of natural compounds in Alzheimer’s disease therapeutics	11
Biocidal and antibiofilm activities of arginine-based surfactants against Candida isolates	11
Chiral resolution of plasma amino acids reveals enantiomer-selective associations with organ functions	11
Peptide OA-VI12 restrains melanogenesis in B16 cells and C57B/6 mouse ear skin via the miR-122-5p/Mitf/Tyr axis	11
PDZK1 improves ventricular remodeling in hypertensive rats by regulating the stability of the Mas receptor	11
Solid-phase synthesis of d-fructose-derived Heyns peptides utilizing Nα-Fmoc-Lysin[Nε-(2-deoxy-d-glucos-2-yl),Nε-Boc]-OH as building block	10
Free amino acid contents of selected Ethiopian plant and fungi species: a search for alternative natural free amino acid sources for cosmeceutical applications	10
Acetylcholine hydrolytic activity of fibrillated β-amyloid (1–40) peptide	10
Early vascular ageing phenotypes and urinary targeted metabolomics in children and young adults: the ExAMIN Youth SA and African-PREDICT studies	10
Disruption of kynurenine pathway reveals physiological importance of tryptophan catabolism in Henosepilachna vigintioctopunctata	10
Scope and limitations of pseudoprolines as individual amino acids in peptide synthesis	10
Serum metabolomics study of narcolepsy type 1 based on ultra-performance liquid chromatography–tandem mass spectrometry	10
Effect of lipopeptide extracted from Bacillus licheniformis on the expression of bap and luxI genes in multi-drug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa	10
Automatic radiosynthesis and preclinical evaluation of 18F-AlF-PSMA-NF as a potential PET probe for prostate cancer imaging	10
Love is in the hair: arginine methylation of human hair proteins as novel cardiovascular biomarkers	10
The effect of insulin resistance on extracellular BCAA accumulation and SLC25A44 expression in a myotube model of skeletal muscle insulin resistance	10
Antimicrobial peptide-loaded decellularized placental sponge as an excellent antibacterial skin substitute against XDR clinical isolates	10
Electrostatically induced pKa shifts in oligopeptides: the upshot of neighboring side chains	9
L-leucine stimulation of glucose uptake and utilization involves modulation of glucose – lipid metabolic switch and improved bioenergetic homeostasis in isolated rat psoas muscle ex vivo	9
Specific and sensitive GC–MS analysis of hypusine, Nε-(4-amino-2-hydroxybutyl)lysine, a biomarker of hypusinated eukaryotic initiation factor eIF5A, and its application to the bi-ethnic ASOS study	9
Interorgan amino acid interchange in propionic acidemia: the missing key to understanding its physiopathology	9
A mix of functional amino acids and grape polyphenols promotes the growth of piglets, modulates the gut microbiota in vivo and regulates epithelial homeostasis in intestinal organoids	9
Synthesis and dopamine receptor binding of dihydrexidine and SKF 38393 catecholamine-based analogues	9
Racemization-free synthesis of Nα-2-thiophenoyl-phenylalanine-2-morpholinoanilide enantiomers and their antimycobacterial activity	9
A systematic review of preclinical studies on the efficacy of taurine for the treatment of rheumatoid arthritis	9
miR27a, a fine-tuning molecule, interacts with growth hormone (GH) signaling and ornithine decarboxylase (ODC) via targeting STAT5	9
Membrane interactions of Ocellatins. Where do antimicrobial gaps stem from?	9
Sulbactam improves binding property and uptake capacity of glutamate transporter-1 and decreases glutamate concentration in the CA1 region of hippocampus of global brain ischemic rats	9
Angiotensin-(3–7) alleviates isoprenaline-induced cardiac remodeling via attenuating cAMP-PKA and PI3K/Akt signaling pathways	9
Tolerable amounts of amino acids for human supplementation: summary and lessons from published peer-reviewed studies	9
Promotion of rs3746804 (p. L267P) polymorphism to intracellular SLC52A3a trafficking and riboflavin transportation in esophageal cancer cells	9
Structural and evolutionary exploration of the IL-3 family and its alpha subunit receptors	9
Investigation of the structure–activity relationship in a series of new LVV- and VV-hemorphin-7 analogues designed as potential anticonvulsant agents	9
Potent bactericidal activity of reduced cryptdin-4 derived from its hydrophobicity and mediated by bacterial membrane disruption	9
Straightforward synthesis of various chiral pyrimidines bearing a stereogenic center adjacent to the C-2 position, including C-terminal peptide isosteres	8
Sex-related differences in plasma amino acids of patients with ST-elevation myocardial infarction and glycine as risk marker of acute heart failure with preserved ejection fraction	8
The association of fasting plasma thiol fractions with body fat compartments, biomarker profile, and adipose tissue gene expression	8
Attenuation of doxorubicin-induced oxidative damage in rat brain by regulating amino acid homeostasis with Astragali Radix	8
Deciphering the conformational landscape of few selected aromatic noncoded amino acids (NCAAs) for applications in rational design of peptide therapeutics	8
Bioactive peptide apelin rescues acute kidney injury by protecting the function of renal tubular mitochondria	8
A strategy can be used to analyze intracellular interaction proteomics of cell-surface receptors	8
Large-scale analysis of circulating glutamate and adipose gene expression in relation to abdominal obesity	8
Protein cysteine S-glycosylation: oxidative hydrolysis of protein S-glycosidic bonds in aqueous alkaline environments	8
Characterization of thermostable serine hydroxymethyltransferase for β-hydroxy amino acids synthesis	8
Altered kynurenine pathway metabolism and association with disease activity in patients with systemic lupus	8
PepQSAR: a comprehensive data source and information platform for peptide quantitative structure–activity relationships	8
Effect of AMPK activation and glucose availability on myotube LAT1 expression and BCAA utilization	8
Absence of endogenous carnosine synthesis does not increase protein carbonylation and advanced lipoxidation end products in brain, kidney or muscle	8
Elevated serum levels of kynurenine pathway metabolites in patients with Behçet disease	8
GABAergic circuits of the basolateral amygdala and generation of anxiety after traumatic brain injury	8
The serum amino acid profile in COVID-19	8
C-terminus amidation influences biological activity and membrane interaction of maculatin 1.1	8
Editorial	7
Determination of amino acids in human biological fluids by high-performance liquid chromatography: critical review	7
Leucine ingestion promotes mTOR translocation to the periphery and enhances total and peripheral RPS6 phosphorylation in human skeletal muscle	7
Developmental dynamics of homoarginine, ADMA and SDMA plasma levels from birth to adolescence	7
Comparison of homocitrulline and carbamylated albumin as biomarkers of carbamylation reactions in hemodialyzed patients	7
Lyophilization and homogenization of biological samples improves reproducibility and reduces standard deviation in molecular biology techniques	7
The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review	7
Ferrihydrite synthesis in the presence of amino acids and artificial seawater	7
Proline metabolism in cancer	7
Common pathogenic bacteria-induced reprogramming of the host proteinogenic amino acids metabolism	7
Alkali salts of amino acids as alkaline additives for neutralization of acidic corrosion inhibitors	7
Polyglutamylation: biology and analysis	7
Emerging effects of tryptophan pathway metabolites and intestinal microbiota on metabolism and intestinal function	7
Possible role of SIRT1 and SIRT3 in post-translational modifications in human breast milk during the neonatal period	7
Correlation between serum carnosinase concentration and renal damage in diabetic nephropathy patients	7
Binding of berberine to PEBP1 synergizes with sorafenib to induce the ferroptosis of hepatic stellate cells	7
Global effects of RAB3GAP1 dysexpression on the proteome of mouse cortical neurons	7
Paternal exposure to excessive methionine altered behavior and neurochemical activities in zebrafish offspring	7
Complex relationship between amino acids, fitness and food intake in Bombus terrestris	6
Neuroprotective effect of newly synthesized 4-aminopyridine derivatives on cuprizone-induced demyelination in mice—a behavioral and immunohistochemical study	6
Far-UV circular dichroism signatures indicate fluorophore labeling induced conformational changes of penetratin	6
Novel antimicrobial cruzioseptin peptides extracted from the splendid leaf frog, Cruziohyla calcarifer	6
Furanonyl amino acid derivatives as hemostatic drugs: design, synthesis and hemostasis performance	6
Integrated transcriptomic and proteomic analyses for the characterization of parathyroid oxyphil cells in uremic patients	6
BR-bombesin: a novel bombesin-related peptide from the skin secretion of the Chaco tree frog (Boana raniceps) with physiological gastric effects	6
PYCR, a key enzyme in proline metabolism, functions in tumorigenesis	6
Gamma-gliadin specific celiac disease antibodies recognize p31-43 and p57-68 alpha gliadin peptides in deamidation related manner as a result of cross-reaction	6

Hypusinated EIF5A as a feasible drug target for Advanced Medicinal Therapies in the treatment of pathogenic parasites and therapy-resistant tumors	6
Identifying a role for the interaction of homocysteine and copper in promoting cardiovascular-related damage	6
Activation of proline metabolism maintains ATP levels during cocaine-induced polyADP-ribosylation	6
Intramolecular cyclization of isothiocyanyl amino acids/peptide: arrival at unnatural thioxoimidazolidinyl/thioxooxazolidinyl amino acids	6
Overexpression of recombinant proteins containing non-canonical amino acids in Vibrio natriegens: p-azido-L-phenylalanine as coupling site for 19F-tags	6
Effects of the l-tyrosine-derived bacterial metabolite p-cresol on colonic and peripheral cells	6
Biochemistry of plants N–heterocyclic non-protein amino acids	6
The effect of acidic pH on the adsorption and lytic activity of the peptides Polybia-MP1 and its histidine-containing analog in anionic lipid membrane: a biophysical study by molecular dynamics and sp	6
Cytoprotective effect of taurine against sodium chlorate-induced oxidative damage in human red blood cells: an ex vivo study	6
Effects of time-of-day on the concentration of defined excitatory and inhibitory amino acids in the cerebrospinal fluid of rats: a microdialysis study	6
Molecular species of oxidized phospholipids in brain differentiate between learning- and memory impaired and unimpaired aged rats	6
Taurine supplementation enhances endurance capacity by delaying blood glucose decline during prolonged exercise in rats	6
Current status of PTMs structural databases: applications, limitations and prospects	6
Hypertension alters the function and expression profile of the peptide cotransporters PEPT1 and PEPT2 in the rodent renal proximal tubule	6
Post-translational modifications (PTM): analytical approaches, signaling, physiology and pathophysiology—part I	5
Epibrassinolide prevents tau hyperphosphorylation via GSK3β inhibition in vitro and improves Caenorhabditis elegans lifespan and motor deficits in combination with roscovitine	5
A novel family of non-secreted tridecaptin lipopeptide produced by Paenibacillus elgii	5
Accurately quantified plasma free glycine concentration as a biomarker in patients with acute ischemic stroke	5
Impact of essential amino acid intake, resistance exercise, and aging on the concentration of Achilles peritendinous amino acids and procollagen Iα1 in humans	5
Dietary supplementation with l-arginine between days 14 and 25 of gestation enhances NO and polyamine syntheses and the expression of angiogenic proteins in porcine placentae	5
Vanadium carbide MXene: as a reductant for the synthesis of gold nanoparticles and its biosensing application	5
Rationally designed PMAP-23 derivatives with enhanced bactericidal and anticancer activity based on the molecular mechanism of peptide–membrane interactions	5
The first evidence of biological activity for free Hypusine, an enigmatic amino acid discovered in the '70s	5
Divergent synthesis of biologically active l-threo-β-hydroxyaspartates from common trans-oxazolidine dicarboxylate	5
Exploring details about structure requirements based on antioxidant tripeptide derived from β-Lactoglobulin by in silico approaches	5
Postprandial amino acid availability after intake of intact or hydrolyzed meat protein in a mixed meal in healthy elderly subjects: a randomized, single blind crossover trial	5
Correction to: The novel inhibitors of serine proteases	5
Thermal tolerance role of novel polyamine, caldopentamine, identified in fifth instar Bombyx mori	5
Covalent-reversible peptide-based protease inhibitors. Design, synthesis, and clinical success stories	5
Synthesis and biological study of new galanthamine-peptide derivatives designed for prevention and treatment of Alzheimer’s disease	5
Development of a 2-pyrrolidone biosynthetic pathway in Corynebacterium glutamicum by engineering an acetyl-CoA balance route	5
Stereoselective synthesis of S-norvaline and related amino acids through a common intermediate	5
Chemical properties of inner and surficial regions of hydrogen-bonded clusters of biological molecules: ultraviolet photodissociation and water adsorption analyses in the gas phase	5
Correction to: The association of fasting plasma thiol fractions with body fat compartments, biomarker profile, and adipose tissue gene expression	5
Structural insights into the amino acid usage variations in the profilin gene family	4
Screening of commonly prescribed drugs for effects on the CAT1-mediated transport of l-arginine and arginine derivatives	4
Effect of l-serine on oxidative stress markers in the kidney of streptozotocin-induced diabetic mice	4
Voltammetric studies of glutathione transfer across arrays of liquid–liquid microinterfaces for sensing applications	4
Allyl isothiocyanate inhibits invasion and angiogenesis in breast cancer via EGFR-mediated JAK-1/STAT-3 signaling pathway	4
Amino acid analysis as a method of discovering biomarkers for diagnosis of diabetes and its complications	4
Methionine sulfoxide and the methionine sulfoxide reductase system as modulators of signal transduction pathways: a review	4
Transcriptome analysis of l-leucine-producing Corynebacterium glutamicum under the addition of trimethylglycine	4
Fast killing kinetics, significant therapeutic index, and high stability of melittin-derived antimicrobial peptide	4
Meta-proteomic analysis of two mammoth’s trunks by EVA technology and high-resolution mass spectrometry for an indirect picture of their habitat and the characterization of the collagen type I, alpha-	4
HPLC method with post-column derivatization for the analysis of endogenous histidine in human saliva validated using the total-error concept	4
Characterization of a polyclonal antibody that is highly selective for the d-isoAsp-25 variant of mammalian histone H2B	4
Editorial	4
Protective effects of glycine against lipopolysaccharide-induced intestinal apoptosis and inflammation	4
The optimum dietary methionine requirement of juvenile humpback grouper (Cromileptes altivelis): effects on growth, micromorphology, protein and lipid metabolism	4
Amino acid metabolism dysregulation associated with inflammation and insulin resistance in HIV-infected individuals with metabolic disorders	4
Untargeted metabolomics analysis of plasma metabolic characteristics in patients with acne and insulin resistance	4
Design and modification of frog skin peptide brevinin-1GHa with enhanced antimicrobial activity on Gram-positive bacterial strains	4
N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties	4
Methylarginine efflux in nutrient-deprived yeast mitigates disruption of nitric oxide synthesis	4
Longitudinal metabolomics profiling of serum amino acids in rotenone-induced Parkinson's mouse model	4
A two-step ensemble learning for predicting protein hot spot residues from whole protein sequence	4
Authentication of three main commercial Pheretima based on amino acids analysis	4
Uterine histotroph and conceptus development: III. Adrenomedullin stimulates proliferation, migration and adhesion of porcine trophectoderm cells via AKT-TSC2-MTOR cell signaling pathway	4
Microbiota-derived tryptophan metabolites in vascular inflammation and cardiovascular disease	4
DeepBSRPred: deep learning-based binding site residue prediction for proteins	4
LEAP2 has antagonized the ghrelin receptor GHSR1a since its emergence in ancient fish	4
Polyamine synthesis from arginine and proline in tissues of developing chickens	4
Chemical approaches in the development of natural nontoxic peptide Polybia-MP1 as a potential dual antimicrobial and antitumor agent	4
Carnosine increases insulin-stimulated glucose uptake and reduces methylglyoxal-modified proteins in type-2 diabetic human skeletal muscle cells	4
Greater plasma essential amino acids and lower 3-methylhistidine with higher protein intake during endurance training: a randomised control trial	4
Urinary excretion of asymmetric (ADMA) and symmetric (SDMA) dimethylarginine is positively related to nitric oxide level in tissues of normotensive and hypertensive rats	4