OOIR: Observatory of International Research

Papers

(The H4-Index of Phytomedicine is 61. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Rosmarinic acid potentiates and detoxifies tacrine in combination for Alzheimer's disease	308
“Retraction notice to “Borneol Enhances the Protective Effect Against Cerebral Ischemia/Reperfusion Injury by Promoting the Access of Astragaloside IV and the Components of Panax Notoginseng Saponins	296
Tiaogeng decoction improves mild cognitive impairment in menopausal APP/PS1 mice through the ERs/NF-κ b/AQP1 signaling pathway	192
Exploring the active components and potential mechanisms of Zhimu-Huangbai herb-pair in the treatment of depression	182
Na+-K+-ATPase/GLT-1 interaction participates in EGCG protection against cerebral ischemia-reperfusion injury in rats	158
Peiyuan Ningshen-ointment alleviates learning and memory impairment induced by sleep deprivation through activating the cAMP/PKA signaling pathway	129
Hesperetin promotes DOT1L degradation and reduces histone H3K79 methylation to inhibit gastric cancer metastasis	126
Pleiotropic role of TLR2-mediated signaling in the protection of psoralidin against sepsis-induced acute lung injury	120
WITHDRAWN: ESP-B4 promotes nasal epithelial cell-derived extracellular vesicles containing miR-146a-5p to modulate Smad3/GATA-3 thus relieving allergic rhinitis	119
Euphorbia helioscopia L. exhibits promising therapeutic effects on hemangioendothelioma and melanoma through angiogenesis inhibition	108
Kirenol alleviates cerebral ischemic injury by promoting synaptic plasticity via HDAC2-mediated BDNF expression	106
Exploring trends in natural product-based treatments to skin burn: A comprehensive review	104
Enhancing Curcumol Delivery through PD-1 Targeted Nanocarriers: A Novel Therapeutic Approach for Prostate Cancer	101
Glaucocalyxin a protect liver function via inhibiting platelet over-activation during sepsis	101
Daphne genkwa flower extract promotes the neuroprotective effects of microglia	101
Flavonoids extract from the seeds of Psoralea corylifolia L. (PFE) alleviates atherosclerosis in high-fat diet-induced LDLR−/− mice	99
Luteolin ameliorates hypoxia-induced pulmonary hypertension via regulating HIF-2α-Arg-NO axis and PI3K-AKT-eNOS-NO signaling pathway	97
Ginsenoside-Rg1 acts as an IDO1 inhibitor, protects against liver fibrosis via alleviating IDO1-mediated the inhibition of DCs maturation	97
Salvianolic acid B suppresses hepatic stellate cell activation and liver fibrosis by inhibiting the NF-κB signaling pathway via miR-6499-3p/LncRNA-ROR	97
Tenacissoside G synergistically potentiates inhibitory effects of 5-fluorouracil to human colorectal cancer	95
Role of polyphenols in the management of diabetic complications	91
Chlorogenic acid improves the cognitive deficits of sleep-deprived mice via regulation of immunity function and intestinal flora	86
Isorhamnetin induces cell cycle arrest and apoptosis by triggering DNA damage and regulating the AMPK/mTOR/p70S6K signaling pathway in doxorubicin-resistant breast cancer	86
Baicalin protects against insulin resistance and metabolic dysfunction through activation of GALR2/GLUT4 signaling	85
Cardioprotective effect of icariin against myocardial fibrosis and its molecular mechanism in diabetic cardiomyopathy based on network pharmacology: Role of ICA in DCM	84

Effect of paeoniflorin on acute lung injury induced by influenza A virus in mice. Evidences of its mechanism of action	82
Mechanisms for the biological activity of Gastrodia elata Blume and its constituents: A comprehensive review on sedative-hypnotic, and antidepressant properties	82
Lupeol alleviates autoimmune myocarditis by suppressing macrophage pyroptosis and polarization via PPARα/LACC1/NF-κB signaling pathway	81
A promising natural anthraquinones mediated by photodynamic therapy for anti-cancer therapy	80
Isoorientin attenuates doxorubicin-induced cardiac injury via the activation of MAPK, Akt, and Caspase-dependent signaling pathways	79
Saucerneol attenuates nasopharyngeal carcinoma cells proliferation and metastasis through selectively targeting Grp94	78
Xin-yi-san contains potent human CYP1A2 inhibitors and its combined use with theophylline in treatment increases adverse risks in patients	77
Discovery of a novel anti-obesity meroterpenoid agent targeted subcutaneous adipose tissue	77
5-Demethylnobiletin: Insights into its pharmacological activity, mechanisms, pharmacokinetics and toxicity	76
Effect of modified Jianpi Yangzheng on regulating content of PKM2 in gastric cancer cells-derived exosomes	76
Madecassoside alleviates acute kidney injury by regulating JNK-mediated oxidative stress and programmed cell death	75
Protopanaxatriol activates EGFR and HER2 to strengthen the molecules of skin protection in human keratinocytes	73
Compounds derived from Humulus lupulus inhibit SARS-CoV-2 papain-like protease and virus replication	71
Effects of adjunctive Chinese patent medicine on outcome of viral encephalitis in children: A multicenter retrospective study in China	71
Systematic review and meta-analysis on the efficacy and safety of Injectable Lentinan combined with chemotherapy in the treatment of gastric cancer	70
Aristolone in Nardostachys jatamansi DC. induces mesenteric vasodilation and ameliorates hypertension via activation of the KATP channel and PDK1-Akt-eNOS pathway	70
Phytomedicine mourns the death of its founding editor Professor Hildebert Wagner	70
Frankincense vinegar-processing improves the absorption of boswellic acids by regulating bile acid metabolism	69
Critical quality appraisal of randomized controlled trials with traditional Chinese medicines for the coronavirus disease 2019	69
Ethyl acetate extract of Antenoron Filiforme inhibits the proliferation of triple negative breast cancer cells via suppressing Skp2/p21 signaling axis	69
Effects and mechanisms of tanshinone IIA on PTSD-like symptoms	69
Celastrol targets the ChREBP-TXNIP axis to ameliorates type 2 diabetes mellitus	67
Hibiscus syriacus L. cultivated in callus culture exerts cytotoxicity in colorectal cancer via Notch signaling-mediated cholesterol biosynthesis suppression	67
The Sanbi Decoction alleviates intervertebral disc degeneration in rats through intestinal flora and serum metabolic homeostasis modulation	67
Evaluating Cannabis sativa L.’s neuroprotection potential: From bench to bedside	66
An enriched polyphenolic extract obtained from the by-product of Rosa damascena hydrodistillation activates antioxidant and proteostatic modules	65
Caffeine enhances chemosensitivity to irinotecan in the treatment of colorectal cancer	65
Nimbolide inhibits 2D and 3D prostate cancer cells migration, affects microtubules and angiogenesis and suppresses B-RAF/p.ERK-mediated in vivo tumor growth	65
The extracts of Dracaena cochinchinensis stemwood suppress inflammatory response and phagocytosis in lipopolysaccharide-activated microglial cells	65
Vibsane-type diterpenoids from Viburnum odoratissimum inhibit hepatocellular carcinoma cells via the PI3K/AKT pathway	65
Antifibrotic activities of Scutellariae Radix extracts and flavonoids: Comparative proteomics reveals distinct and shared mechanisms	64
Cinnamaldehyde alleviates aspirin-induced gastric mucosal injury by regulating pi3k/akt pathway-mediated apoptosis, autophagy and ferroptosis	64
Progress on the effects and underlying mechanisms of evodiamine in digestive system diseases, and its toxicity: A systematic review and meta-analysis	64
A comprehensive review of natural product-derived compounds acting on P2X7R: The promising therapeutic drugs in disorders	63
Alisol B regulates AMPK/mTOR/SREBPs via directly targeting VDAC1 to alleviate hyperlipidemia	63
Anti-inflammatory effects of quinolinyl analog of resveratrol targeting TLR4 in MCAO/R ischemic stroke rat model	62
Cardioprotective effects of curcumin against Diabetic Cardiomyopathies: A systematic review and meta-analysis of preclinical studies	61
Nobiletin inhibits de novo FA synthesis to alleviate gastric cancer progression by regulating endoplasmic reticulum stress	61