OOIR: Observatory of International Research

Papers

(The median citation count of Matrix Biology is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Thrombospondin-1 promotes mechanical stress-mediated ligamentum flavum hypertrophy through the TGFβ1/Smad3 signaling pathway	53
Optic neuropathy associated with TGFβ dysregulation in mice with a glaucoma-causative mutation of ADAMTS10	53
Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development	52
Beyond the matrisome: New frontiers in ECM research	43
ADAMTS6 cleaves the large latent TGFβ complex and increases the mechanotension of cells to activate TGFβ	43
Targeting the αVβ3/NgR2 pathway in neuroendocrine prostate cancer	42
Tumor and stroma COL8A1 secretion induces autocrine and paracrine progression signaling in pancreatic ductal adenocarcinoma	37
Neurocan regulates axon initial segment organization and neuronal activity	30
Corrigendum to “Syndecan-1 shedding by meprin β impairs keratinocyte adhesion and differentiation in hyperkeratosis”	30
Obesity impairs skeletal muscle repair through NID-1 mediated extracellular matrix remodeling by mesenchymal progenitors	29
A top-down approach to uncover the hidden ligandome of low-density lipoprotein receptor-related protein 1 in cartilage	28
Collagen XVIII regulates extracellular matrix integrity in the developing nephrons and impacts nephron progenitor cell behavior	28
Identification of Periostin as a critical niche for myofibroblast dynamics and fibrosis during tendon healing	27
Hyperglycemic environments directly compromise intestinal epithelial barrier function in an organoid model and hyaluronan (∼35 kDa) protects via a layilin dependent mechanism	25
Tumor-associated fibrosis impairs the response to immunotherapy	24
The dynamic kidney matrisome - is the circadian clock in control?	24
Age related changes in hyaluronan expression leads to Meibomian gland dysfunction	24
Effects of hydrostatic pressure, osmotic pressure, and confinement on extracellular matrix associated responses in the nucleus pulposus cells ex vivo	22
Molecular and epigenetic ex vivo profiling of testis cancer-associated fibroblasts and their interaction with germ cell tumor cells and macrophages	22
Nanoscale characterization of collagen structural responses to in situ loading in rat Achilles tendons	22
Dysfunctional latent transforming growth factor β activation after corneal injury in a classical Ehlers–Danlos model	22
The epidermal integrin-mediated secretome regulates the skin microenvironment during tumorigenesis and repair	22
Temporally and spatially regulated collagen XVIII isoforms are involved in ureteric tree development via the TSP1-like domain	22
Multi-factorial nerve guidance conduit engineering improves outcomes in inflammation, angiogenesis and large defect nerve repair	21
Inhibition of the MRTF-A/SRF signaling axis alleviates vocal fold scarring	21

Novel regulatory roles of small leucine-rich proteoglycans in remodeling of the uterine cervix in pregnancy	21
Tumor vascular remodeling by thrombospondin-1 enhances drug delivery and antineoplastic activity	21
Fibroblast integrin α11β1 is a collagen assembly receptor in mechanoregulated fibrillar adhesions	21
Spatial localization of collagen hydroxylated proline site variation as an ancestral trait in the breast cancer microenvironment	20
The integral role of fibronectin in skeletal morphogenesis and pathogenesis	20
Global, but not chondrocyte-specific, MT1-MMP deficiency in adult mice causes inflammatory arthritis	19
Hyaluronan in the pathogenesis of acute and post-acute COVID-19 infection	19
Sdc4 deletion perturbs intervertebral disc matrix homeostasis and promotes early osteopenia in the aging mouse spine	19
Peptide location fingerprinting identifies structural alterations within basement membrane components in ageing kidney	19
Amino acid sensory complex proteins in mTORC1 and macroautophagy regulation	19
Tissue mechanics coevolves with fibrillar matrisomes in healthy and fibrotic tissues	18
Different molecular weights of hyaluronan research in knee osteoarthritis: A state-of-the-art review	18
Mitochondrial DNA mutations attenuate Bleomycin-induced dermal fibrosis by inhibiting differentiation into myofibroblasts	18
Secreted ADAMTS-like 2 promotes myoblast differentiation by potentiating WNT signaling	17
George R. Martin: Pioneering matrix biologist	17
Matricellular protein CCN1 promotes collagen alignment and scar integrity after myocardial infarction	17
Collagen VII maintains proteostasis in dermal fibroblasts by scaffolding TANGO1 cargo	17
35kDa hyaluronan ameliorates ethanol driven loss of anti-microbial defense and intestinal barrier integrity in a TLR4-dependent manner	16
LPA-induced expression of CCN2 in muscular fibro/adipogenic progenitors (FAPs): Unraveling cellular communication networks	16
RIPK3-MLKL signaling activates mitochondrial CaMKII and drives intrarenal extracellular matrix production during CKD	16
Biglycan: A regulator of hepatorenal inflammation and autophagy	16
O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development	16
Tonic repression of collagen I by the bradykinin receptor 2 in skin fibroblasts	16
Lamellar thickness measurements in control and osteogenesis imperfecta human bone, with development of a method of automated thickness averaging to simplify quantitation	16
Mysteries of the collagen triple helix	16
The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix	16
Toward a rational therapeutic for elastin related disease: Key considerations for elastin based regenerative medicine strategies	15
Remodeling of the extracellular matrix by serine proteases as a prerequisite for cancer initiation and progression	15
Editorial Board	15
Chemotherapy treatment induces pro-invasive changes in liver ECM composition	15
Lack of the myotendinous junction marker col22a1 results in posture and locomotion disabilities in zebrafish	15
Surveillance of nucleolar homeostasis and ribosome maturation by autophagy and the ubiquitin-proteasome system	15
ECM-regulation of autophagy: The yin and the yang of autophagy during wound healing	14
Mechanistic interrogation of mutation-independent disease modulators of RDEB identifies the small leucine-rich proteoglycan PRELP as a TGF-β antagonist and inhibitor of fibrosis	14
Role of syndecan-4 in angiogenesis and vasculogenic mimicry in triple negative breast cancer cells	14
Circulating collagen type I fragments as specific biomarkers of cardiovascular outcome risk: Where are the opportunities?	14
Collagen VI deposition mediates stromal T cell trapping through inhibition of T cell motility in the prostate tumor microenvironment	14
Scleraxis and collagen I expression increase following pilot isometric loading experiments in a rodent model of patellar tendinopathy	14
Extracellular matrix integrity regulates GABAergic plasticity in the hippocampus	14
Fiber alignment in 3D collagen networks as a biophysical marker for cell contractility	14
What does it take to be a collagen receptor?	14
Accumulation of versican and lack of versikine ameliorate acute colitis	14
The INSR/AKT/mTOR pathway regulates the pace of myogenesis in a syndecan-3-dependent manner	14
Structural insights on perlecan and Schwartz–Jampel syndrome	13
Controlled extracellular proteolysis of thrombospondins	13
Conditional expression of endorepellin in the tumor vasculature attenuates breast cancer growth, angiogenesis and hyaluronan deposition	13
Human intestinal myofibroblasts deposited collagen VI enhances adhesiveness for T cells – A novel mechanism for maintenance of intestinal inflammation	13
Syndecan-1 shedding by meprin β impairs keratinocyte adhesion and differentiation in hyperkeratosis	13
IGF-II regulates lysyl oxidase propeptide and mediates its effects in part via basic helix-loop-helix E40	13
PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis	13

Matrisome alterations in obesity – Adipose tissue transcriptome study on monozygotic weight-discordant twins	13
S100A4 a classical DAMP as a therapeutic target in fibrosis	13
Fibrolamellar carcinomas–growth arrested by paracrine signals complexed with synthesized 3-O sulfated heparan sulfate oligosaccharides	12
Molecular mechanisms mediating stiffening in the mechanically adaptable connective tissues of sea cucumbers	12
Collagen VI ablation in zebrafish causes neuromuscular defects during developmental and adult stages	12
SIRT4 protects against intestinal fibrosis by facilitating GLS1 degradation	12
Involvement of lysophosphatidic acid-LPA1-YAP signaling in healthy and pathological FAPs migration	12
Editorial Board	12
EphA2 signaling within integrin adhesions regulates fibrillar adhesion elongation and fibronectin deposition	12
Stiffness-responsive feedback autoregulation of DDR1 expression is mediated by a DDR1-YAP/TAZ axis	12
Mmp14 is required for matrisome homeostasis and circadian rhythm in fibroblasts	12
Loss of BTK ameliorates the pathological cardiac fibrosis and dysfunction	12
CD45+/ Col I+ Fibrocytes: Major source of collagen in the fibrotic lung, but not in passaged fibroblast cultures	12
En route towards a personalized medicine approach: Innovative therapeutic modalities for connective tissue disorders	11
Mechanical loading is required for initiation of extracellular matrix deposition at the developing murine myotendinous junction	11
Shed syndecan-2 enhances colon cancer progression by increasing cooperative angiogenesis in the tumor microenvironment	11
Editorial Board	11
Cancer-associated fibroblasts promote proliferation, angiogenesis, metastasis and immunosuppression in gastric cancer	11
Cell differentiation and matrix organization are differentially affected during bone formation in osteogenesis imperfecta zebrafish models with different genetic defects impacting collagen type I stru	11
Mammary collagen is under reproductive control with implications for breast cancer	11
Health consequences of mutant cartilage oligomeric matrix protein and its relationship to abnormal growth and joint degeneration	11
Analysis of extracellular matrix network dynamics in cancer using the MatriNet database	11
An adapted passive model of anti-MPO dependent crescentic glomerulonephritis reveals matrix dysregulation and is amenable to modulation by CXCR4 inhibition	10
Tissue-specific collagen hydroxylation at GEP/GDP triplets mediated by P4HA2	10
Vertebrate extracellular matrix protein hemicentin-1 interacts physically and genetically with basement membrane protein nidogen-2	10
Site-specific glycosylation of proteoglycans: A revisited frontier in proteoglycan research	10
Myeloid deficiency of heparan sulfate 6-O-endosulfatases impairs bone marrow hematopoiesis	10
AβPP-tau-HAS1 axis trigger HAS1-related nuclear speckles and gene transcription in Alzheimer's disease	10
Novel insights into the role of Discoidin domain receptor 2 (DDR2) in cancer progression: a new avenue of therapeutic intervention	10
Matrix stiffness increases energy efficiency of endothelial cells	10
Editorial Board	10
The phosphorylation of serine55 in enamelin is essential for murine amelogenesis	10
Cleavage of Cartilage Oligomeric Matrix Protein (COMP) by ADAMTS4 generates a neoepitope associated with osteoarthritis and other forms of degenerative joint disease	10
Corrigendum to “Fibrolamellar carcinomas–growth arrested by paracrine signals complexed with synthesized 3-O sulfated heparan sulfate oligosaccharides” [Matrix Biology 121(August 2023), 194–216]	10
Autophagy, tissue repair, and fibrosis: a delicate balance	10
Impact of vascular Ehlers-Danlos Syndrome-associated Gly substitutions on structure, function, and mechanics using bacterial collagen	10
A role for decorin in improving motor deficits after traumatic brain injury	9
Modulation of the expression and activity of cathepsin S in reconstructed human skin by neohesperidin dihydrochalcone	9
Integrins and integrin-driven secretory pathways as multi-dimensional regulators of tumor-associated macrophage recruitment and reprogramming in tumor microenvironment	9
Interleukin-1α inhibits transforming growth factor-β1 and β2-induced extracellular matrix production, remodeling and signaling in human lung fibroblasts: Master regulator in lung mucosal repair	9
Emilin2 fosters vascular stability by promoting pericyte recruitment	9
Collagen prolyl 4-hydroxylase isoenzymes I and II have sequence specificity towards different X-Pro-Gly triplets	9
A functional outside-in signaling network of proteoglycans and matrix molecules regulating autophagy	9
Using load to improve tendon/ligament tissue engineering and develop novel treatments for tendinopathy	9
Suppression of OGN in lung myofibroblasts attenuates pulmonary fibrosis by inhibiting integrin αv-mediated TGF-β/Smad pathway activation	9
Editorial Board	8
Editorial Board	8
Decoding the MMP14 integrin link: Key player in the secretome landscape	8
Calponin 1 increases cancer-associated fibroblasts-mediated matrix stiffness to promote chemoresistance in gastric cancer	8
Peritoneal restoration by repurposing vitamin D inhibits ovarian cancer dissemination via blockade of the TGF-β1/thrombospondin-1 axis	8
Mutant MESD links cellular stress to type I collagen aggregation in osteogenesis imperfecta type XX	8
Dual transgene amelioration of Lama2-null muscular dystrophy	8
Fibronectin isoforms promote postnatal skeletal development	8
Metabolic control of collagen synthesis	8
Asporin, an extracellular matrix protein, is a beneficial regulator of cardiac remodeling	8
Autophagy: Instructions from the extracellular matrix	8
When lipid homeostasis runs havoc: Lipotoxicity links lysosomal dysfunction to autophagy	8
Dual role of enhancer of zeste homolog 2 in the regulation of ultraviolet radiation-induced matrix metalloproteinase-1 and type I procollagen expression in human dermal fibroblasts	8
A lysyl oxidase-responsive collagen peptide illuminates collagen remodeling in wound healing	8
Ameloblastin promotes polarization of ameloblast cell lines in a 3-D cell culture system	8
The gelatinases, matrix metalloproteinases 2 and 9, play individual roles in skeleton development	7
The endocytic receptor uPARAP is a regulator of extracellular thrombospondin-1	7
Increased expression of the pathological O-glycosylated form of oncofetal fibronectin in the multidrug resistance phenotype of cancer cells	7
Autocrine IL-6 drives cell and extracellular matrix anisotropy in scar fibroblasts	7
Heparanase 2 (Hpa2) attenuates the growth of human sarcoma	7
Alterations in the microenvironment of junctional epidermolysis bullosa keratinocytes: A gene expression study	7
Basement membranes in lung metastasis growth and progression	7
Hyaluronan synthase 3 is protective after cardiac ischemia-reperfusion by preserving the T cell response	7
Editorial Board	7
Hedgehog signaling orchestrates cartilage-to-bone transition independently of Smoothened	7
Versican provides the provisional matrix for uterine spiral artery dilation and fetal growth	7