OOIR: Observatory of International Research

Papers

(The TQCC of Matrix Biology is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Thrombospondin-1 promotes mechanical stress-mediated ligamentum flavum hypertrophy through the TGFβ1/Smad3 signaling pathway	73
Optic neuropathy associated with TGFβ dysregulation in mice with a glaucoma-causative mutation of ADAMTS10	53
Role of extracellular space and matrix remodeling in cardiac amyloidosis	50
Basement membrane structure and function: Relating biology to mechanics	37
Transmembrane and multiplexin collagens in development and pathobiology	35
ADAMTS6 cleaves the large latent TGFβ complex and increases the mechanotension of cells to activate TGFβ	34
Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development	33
Corrigendum to “Syndecan-1 shedding by meprin β impairs keratinocyte adhesion and differentiation in hyperkeratosis”	32
The dynamic kidney matrisome - is the circadian clock in control?	31
Beyond the matrisome: New frontiers in ECM research	31
A top-down approach to uncover the hidden ligandome of low-density lipoprotein receptor-related protein 1 in cartilage	30
Tumor and stroma COL8A1 secretion induces autocrine and paracrine progression signaling in pancreatic ductal adenocarcinoma	29
Obesity impairs skeletal muscle repair through NID-1 mediated extracellular matrix remodeling by mesenchymal progenitors	29
Neurocan regulates axon initial segment organization and neuronal activity	28
Collagen XVIII regulates extracellular matrix integrity in the developing nephrons and impacts nephron progenitor cell behavior	27
Hyperglycemic environments directly compromise intestinal epithelial barrier function in an organoid model and hyaluronan (∼35 kDa) protects via a layilin dependent mechanism	27
Identification of Periostin as a critical niche for myofibroblast dynamics and fibrosis during tendon healing	26
Age related changes in hyaluronan expression leads to Meibomian gland dysfunction	26
Targeting the αVβ3/NgR2 pathway in neuroendocrine prostate cancer	26
The epidermal integrin-mediated secretome regulates the skin microenvironment during tumorigenesis and repair	26
Effects of hydrostatic pressure, osmotic pressure, and confinement on extracellular matrix associated responses in the nucleus pulposus cells ex vivo	25
Nanoscale characterization of collagen structural responses to in situ loading in rat Achilles tendons	25
Molecular and epigenetic ex vivo profiling of testis cancer-associated fibroblasts and their interaction with germ cell tumor cells and macrophages	25
Dysfunctional latent transforming growth factor β activation after corneal injury in a classical Ehlers–Danlos model	24
Tumor-associated fibrosis impairs the response to immunotherapy	24

Fibroblast integrin α11β1 is a collagen assembly receptor in mechanoregulated fibrillar adhesions	24
Temporally and spatially regulated collagen XVIII isoforms are involved in ureteric tree development via the TSP1-like domain	24
Multi-factorial nerve guidance conduit engineering improves outcomes in inflammation, angiogenesis and large defect nerve repair	23
Retraction Notice to “RETRACTED: The angiostatic molecule Multimerin 2 is processed by MMP-9 to allow sprouting angiogenesis”	23
RETRACTED: Novel regulatory roles of small leucine-rich proteoglycans in remodeling of the uterine cervix in pregnancy	23
Hyaluronan in the pathogenesis of acute and post-acute COVID-19 infection	22
Inhibition of the MRTF-A/SRF signaling axis alleviates vocal fold scarring	22
Sdc4 deletion perturbs intervertebral disc matrix homeostasis and promotes early osteopenia in the aging mouse spine	21
Loss of col4a1 in zebrafish recapitulates the cerebrovascular phenotypes associated with monogenic cerebral small vessel disease	21
Mitochondrial DNA mutations attenuate Bleomycin-induced dermal fibrosis by inhibiting differentiation into myofibroblasts	21
Collagen VII maintains proteostasis in dermal fibroblasts by scaffolding TANGO1 cargo	21
Secreted ADAMTS-like 2 promotes myoblast differentiation by potentiating WNT signaling	21
The integral role of fibronectin in skeletal morphogenesis and pathogenesis	20
Different molecular weights of hyaluronan research in knee osteoarthritis: A state-of-the-art review	20
Global, but not chondrocyte-specific, MT1-MMP deficiency in adult mice causes inflammatory arthritis	20
Tissue mechanics coevolves with fibrillar matrisomes in healthy and fibrotic tissues	20
Peptide location fingerprinting identifies structural alterations within basement membrane components in ageing kidney	20
Spatial localization of collagen hydroxylated proline site variation as an ancestral trait in the breast cancer microenvironment	20
The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix	19
Lamellar thickness measurements in control and osteogenesis imperfecta human bone, with development of a method of automated thickness averaging to simplify quantitation	19
Mysteries of the collagen triple helix	19
George R. Martin: Pioneering matrix biologist	19
Tonic repression of collagen I by the bradykinin receptor 2 in skin fibroblasts	19
RIPK3-MLKL signaling activates mitochondrial CaMKII and drives intrarenal extracellular matrix production during CKD	19
Matricellular protein CCN1 promotes collagen alignment and scar integrity after myocardial infarction	19
35kDa hyaluronan ameliorates ethanol driven loss of anti-microbial defense and intestinal barrier integrity in a TLR4-dependent manner	18
Editorial Board	17
Toward a rational therapeutic for elastin related disease: Key considerations for elastin based regenerative medicine strategies	17
O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development	17
Chemotherapy treatment induces pro-invasive changes in liver ECM composition	17
LPA-induced expression of CCN2 in muscular fibro/adipogenic progenitors (FAPs): Unraveling cellular communication networks	17
The INSR/AKT/mTOR pathway regulates the pace of myogenesis in a syndecan-3-dependent manner	17
Lack of the myotendinous junction marker col22a1 results in posture and locomotion disabilities in zebrafish	17
Collagen IV biosynthesis: Intracellular choreography of post-translational modifications	17
Editorial Board	17
Role of syndecan-4 in angiogenesis and vasculogenic mimicry in triple negative breast cancer cells	17
Remodeling of the extracellular matrix by serine proteases as a prerequisite for cancer initiation and progression	17
Editorial Board	16
Scleraxis and collagen I expression increase following pilot isometric loading experiments in a rodent model of patellar tendinopathy	16
Mechanistic interrogation of mutation-independent disease modulators of RDEB identifies the small leucine-rich proteoglycan PRELP as a TGF-β antagonist and inhibitor of fibrosis	16
What does it take to be a collagen receptor?	16
FAM20C and FAM20A in normal and ectopic mineralization: A focus on oro-renal syndromes	16
Extracellular matrix integrity regulates GABAergic plasticity in the hippocampus	16
Accumulation of versican and lack of versikine ameliorate acute colitis	16
Mechanical control of breast cancer malignancy by promotion of mevalonate pathway enzyme synthesis	16
Collagen VI deposition mediates stromal T cell trapping through inhibition of T cell motility in the prostate tumor microenvironment	16
Biomechanical and compositional basement membrane defects due to a Col4a1 mutation affect cardiac morphology and function	16
Circulating collagen type I fragments as specific biomarkers of cardiovascular outcome risk: Where are the opportunities?	15
Human intestinal myofibroblasts deposited collagen VI enhances adhesiveness for T cells – A novel mechanism for maintenance of intestinal inflammation	15
Structural insights on perlecan and Schwartz–Jampel syndrome	15

S100A4 a classical DAMP as a therapeutic target in fibrosis	15
Matrisome alterations in obesity – Adipose tissue transcriptome study on monozygotic weight-discordant twins	15
Fiber alignment in 3D collagen networks as a biophysical marker for cell contractility	14
Involvement of lysophosphatidic acid-LPA1-YAP signaling in healthy and pathological FAPs migration	14
Molecular mechanisms mediating stiffening in the mechanically adaptable connective tissues of sea cucumbers	14
Stiffness-responsive feedback autoregulation of DDR1 expression is mediated by a DDR1-YAP/TAZ axis	14
IGF-II regulates lysyl oxidase propeptide and mediates its effects in part via basic helix-loop-helix E40	14
Conditional expression of endorepellin in the tumor vasculature attenuates breast cancer growth, angiogenesis and hyaluronan deposition	14
CD45+/ Col I+ Fibrocytes: Major source of collagen in the fibrotic lung, but not in passaged fibroblast cultures	14
Fibrolamellar carcinomas–growth arrested by paracrine signals complexed with synthesized 3-O sulfated heparan sulfate oligosaccharides	14
SIRT4 protects against intestinal fibrosis by facilitating GLS1 degradation	14
Controlled extracellular proteolysis of thrombospondins	14
Mmp14 is required for matrisome homeostasis and circadian rhythm in fibroblasts	14
Editorial Board	14