OOIR: Observatory of International Research

Papers

(The TQCC of International Journal of Clinical Pharmacology and Therapeutics is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Adverse reaction profile of sulfasalazine and its persistence in chronic therapy of rheumatoid arthritis and spondyloarthritis: A multicentric observational study	31
Search for nutritional and inflammatory marker ratios to predict neutropenia in FEC therapy for breast cancer: A retrospective observational study	12
A decision tree model for predicting high mono-N-desethylamiodarone concentrations and reducing tissue toxicity in patients with low-dose amiodarone therapy: A multicentral retrospective cohort study	10
Activated charcoal helps in the diagnosis of dabigatran overdose: A case study	9
Integrative treatment of the motor neuron disease amyotrophic lateral sclerosis, efficacy of pharmacotherapy, traditional Chinese medicine and importance of respiratory support, life-style, and gastro	9
Potential drug-drug interactions in a multi-center study of death cases of COVID-19: The significance of appropriate drug choice	8
Research progress in targeted therapies for gastric cancer	8
Association between ABCB1 C3435T polymorphism and antiepileptic drug resistance in epilepsy: An updated meta-analysis based on 62 studies	7
Cabotegravir pharmacokinetics in Asians with and without HIV	7
Rare systemic skin hyperpigmentation associated with osimertinib: A case report	7
Network pharmacology analysis and clinical efficacy of the traditional Chinese medicine Bu-Shen-Jian-Pi. Part 2: Modulation of hypoxia, redox status, and mitochondrial protection in a neuroblastoma ce	7
A cross-sectional study on the potential drug-drug interaction risk of COVID-19 patients in hospital	7
Post-marketing safety concerns with montelukast: A pharmacovigilance study based on the FDA adverse event reporting system	7
Self-reported urinary urgency in association with vitamin D and psychiatric symptoms among patients with musculoskeletal pain	6
Retrospective evaluation of medical information for predicting tazobactam/piperacillin-induced liver injury	6
Adverse event profiles of drugs used for treatment of juvenile idiopathic arthritis according to spontaneous reporting system database	6
Interferon α-induced lupus-like reaction in a mycosis fungoides patient: A case report	6
Effects of iguratimod in the treatment of palindromic rheumatism: Case report	6
Sodium-glucose cotransporter-2 inhibitor treatment has differential effects on the incidence of various malignancies: Evidence from a spontaneous adverse reaction database	5
Pegylated-interferon alpha (PEG-IFNα)-induced interstitial lung disease in a patient with chronic hepatitis B: A case report and literature review	5
Factors affecting outcome in hospitalized patients treated according to recommendations from clinical pharmacologists	5
Methylobacterium infection-induced peritonitis in a patient with renal insufficiency: A case report and literature review	5
Potentiation of paclitaxel-induced apoptosis in a non-small cell lung cancer model using the traditional Chinese drug huaier: Network pharmacology analysis, experimental verification, and clinical imp	5
Cost-utility analysis of pembrolizumab versus nivolumab in the treatment of metastatic colorectal cancer from the perspective of the healthcare payer	5
Drug-induced hepatotoxicity linked to zoledronic acid in the treatment of an elderly man with primary osteoporosis	5

The Enhanced Games with doping permitted and Hulk Hogan	5
Pharmacokinetics, safety, and bioequivalence of apixaban tablets in healthy Chinese subjects under fasting and fed conditions	4
Drug-drug interaction between remdesivir and immunosuppressant agents in a kidney transplant recipient	4
Activated charcoal can be used to aid the diagnosis of an overdose of dabigatran etexilate	4
COVID-19 pandemic management using the 14-day projected incidence	4
Bleeding events associated with recombinant human soluble thrombomodulin, classified according to renal function, in sepsis-induced disseminated intravascular coagulation	4
Personalized management of acenocoumarol dosage using eGFR: Analysis of INR data in a cohort of 204 patients	4
Deprescribing proton pump inhibitors: A study in hospitalized patients in Slovenia	4
Elevation of serum creatine kinase induced by anti-thyroid drugs: Two case reports and a literature review	4
Imipenem cilastatin sodium-associated thrombocytopenia in an older patient: A case report and literature review	4
Severe drug-induced immune hemolytic anemia due to cefmetazole: A case report	4
Components in Prunus mume and their targets in the alleviation of severe depression identified using network pharmacology analysis	4
Degree of serum LDL cholesterol reduction by simvastatin and ezetimibe is dependent on baseline LDL cholesterol concentration but not on baseline values and changes in cholesterol synthesis and absorp	4
Tocilizumab: A retrospective multi-center cohort study of critically ill patients with COVID-19	4
Pharmacokinetics and bioequivalence study of two ciprofloxacin hydrochloride tablets in healthy Chinese subjects under fasting and fed conditions: A randomized, open-label, two-formulation, two-sequen	3
Sub-therapeutic trimethoprim and sulfamethoxazole plasma concentrations during continuous venovenous hemofiltration in a patient with COVID-19 and pulmonary Pneumocystis jirovecii co-infection: A case	3
Warfarin pharmacokinetics and pharmacodynamics are not affected by concomitant administration of the long-acting GLP-1 receptor agonist polyethylene glycol loxenatide	3
Bioequivalence study of two formulations of afatinib dimaleate tablets in healthy subjects under fasting conditions: A randomized, open-label, single-dose, crossover trial	3
Intrathecal drug-infusion system for treating pain in advanced cancer: New research in patient management	3
Severe genital cutaneous toxicity with sunitinib	3
Pharmacokinetics and pharmacodynamics of amiodarone in patients with hypertriglyceridemia: Two case reports	3
Comparative efficacy and safety of topiroxostat at different dosages in hyperuricemic patients with or without gout: A network meta-analysis of randomized controlled trials	3
Securing a diagnosis in patients presenting with suspected paracetamol (acetaminophen) poisoning: A retrospective cohort study	3
Evaluation of the risk factors for the failure of a single prophylactic dose of anticholinergic drugs for irinotecan-induced cholinergic symptoms	3
Treatment of severe psoriasis in a hospice care patient using secukinumab, an inhibitor of interleukin-17A expression: Treatment response and changes in quality of life	3
Clinical effects of atomizing inhalation of antibiotics on germ clearance rate and adverse reactions in respiratory infectious diseases: A meta-analysis	3
Simultaneous determination of cefmetazole and cefaclor in urine from pediatric patients with urinary tract infections using a newly developed high-performance liquid chromatography assay method	3
Aplastic anemia associated with osimertinib: Analysis of the FDA adverse event reporting system	3
High-dose ulinastatin reduces postoperative bleeding and provides platelet-protective effects in patients undergoing heart valve replacement surgery	3
Metformin alone and in combination with sitagliptin induces depression and impairs quality of life in type 2 diabetes mellitus patients: An observational study	3
The vancomycin dosage calculator: Prediction superiority and validation in a comparison of four algorithms using retrospective data from non-critical patients aged 18 to 59 years	3
Severe autoimmune hemolytic anemia associated with glucose-6-phosphate dehydrogenase deficiency as a complication of nivolumab treatment: A case report	3
Randomized, open-label, crossover trial comparing the pharmacokinetic profile of a novel oral aspirin solution and a chewed aspirin tablet	3
Pharmacokinetic and bioequivalence of lenalidomide in multiple myeloma patients	3
Pharmacokinetic evaluation and relative bioavailability pilot study of fidaxomicin in healthy Chinese subjects: An open, randomized, single-dose, cross-over study	3
Network target theory and network pharmacology: Next generation drug research in medicine using AI models	2
Evaluation of the comparative pharmacokinetic properties of a new orally disintegrating tablet of tegoprazan in healthy Korean subjects	2
Is compressed colchicine tablet superior to other colchicine preparations in patients with familial Mediterranean fever?	2
Comparison of the acid suppression effects between low-dose esomeprazole and famotidine in healthy subjects	2
Acute myeloid leukemia after 10 years of azathioprine treatment for Crohn’s disease	2
Early acute kidney injury after tacrolimus administration in heart transplant recipients receiving basiliximab induction therapy	2
A rare case of septic shock caused by Serratia marcescens in an immunocompetent male adolescent. Comment on: DOI: 10.5414/CP204652 by Mughrab et al.	2
Ocular myasthenia gravis-like symptoms associated with erenumab: Case report	2
Exogenous insulin antibody syndrome in type 2 diabetes with diabetic ketoacidosis: A case report and literature review	2
Longevity – via traditional Chinese medicine and macrobiotics to AI-driven network pharmacology and clinical pharmacology	2
Successful management of tumor necrosis factor-alpha inhibitor-induced Sweet syndrome in a patient with ulcerative colitis: A case report	2
Latent class analysis of patients’ background factors affecting the risk of specific adverse drug reactions to dipeptidyl peptidase 4 inhibitors	2
Risks of malignant lymphoma in rheumatoid arthritis patients receiving methotrexate-alone and in combination therapy compared with the general population: A study based on a Japanese medical claims da	2
Analysis of risk factors for hypoglycemia in patients with gastrointestinal bleeding induced by somatostatin for injection and establishment of the prediction model	2
Improving the long-term response to antidepressants by establishing an individualized platform based on variability and chronotherapy	2

Pharmacokinetics and bioequivalence of tofacitinib 5 mg in healthy Korean male subjects	2
Inotersen and severe thrombocytopenia: 2 case reports and review	2
Severe hypertriglyceridemia induced by S-1: Subsequent case series of four patients and further review of the literature	2
Evaluating real-world data in COVID-19 antigen and PCR testing	2
Subcutaneous infliximab CT-P13 without intravenous induction in psoriatic arthritis: A case report and pharmacokinetic considerations	2
Association of gynecomastia with antidiabetic medications in older adults: Data mining from different national pharmacovigilance databases	2
Epithelial-mesenchymal transition biomarkers in patients with acute exacerbation of COPD are indicative of disease severity, disease progression, and risk of readmission	2
Bisphosphonates in combination with alendronate sodium increase bone mineral density and modulate IL-6, TNF-α, and IGF-1 in patients with osteoporosis	2
Differentiation of bone marrow mesenchymal stem cells modulated by Bushen Tian Sui decoction via the TGF-β1-Smad2/3 signaling pathway: In vitro evidence and potential clinical application in delayed f	2
Topics in focus 2025 The International Journal of Clinical Pharmacology and Therapeutics	2
Clinical Handbook of Psychotropic Drugs for Children and Adolescents (5th Edition)	2
Analgesia with reduced incidence of adverse reactions using flurbiprofen axetil in combination with half standard-dose opioids in primary total knee arthroplasty	2
Bioavailability study of Enoxaparin Sodium Chemi (80 mg/0.8 mL) and Clexane (80 mg/0.8 mL) subcutaneous injection in healthy adults	2
Changes in the intestinal microbiota of patients with Parkinson’s disease and their clinical significance	2
Prevalence of therapeutic drug monitoring and adherence to imatinib in chronic myeloid leukemia in Japan	2
An unusual case of acute myopericarditis after the first dose of capecitabine: Need for new cardioprotective strategies and risk stratification	2
A randomized, double-blind, three-arm, parallel group, single-dose phase I study to evaluate the pharmacokinetic similarity between SB12 (a proposed eculizumab biosimilar) and eculizumab (Soliris) in	2
Sodium-glucose cotransporter 2 (SGLT2) inhibitors, as potential (off-label) anti-obesity agents and effects on cardiovascular risk: A systematic review and meta-analysis	2
Treatment of delayed fracture healing with Bushen Tiansui decoction: Analysis of active agents and targets using bioinformatics and network pharmacology analysis	2
Can a β-glucan-containing orthomolecular agent (Saccharomyces sp.) containing metabolic cofactors attenuate cytokine activation and alleviate hypoxia in COVID-19 patients?	2
A pharmacokinetic analysis of amisulpride in adult Chinese patients with schizophrenia: Impact of creatinine clearance	2
Neonatal pain score after use of paracetamol: Is there a relationship with serum trough concentration at steady state in preterm and term neonates?	2
Comparative efficacy and safety of etanercept biosimilars in comparison with etanercept in patients with rheumatoid arthritis who have insufficient response to methotrexate: A network meta-analysis	2
Hypersensitivity reaction to high-dose methotrexate and methotrexate-induced acral erythema in a child with acute lymphoblastic leukemia	2