OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Molecular Medicine-Jmm is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
The molecular and cellular landscape of hypertrophic cardiomyopathy phenotypes: transition from obstructive to end-stage heart failure	77
Kat7 accelerates osteoarthritis disease progression through the TLR4/NF-κB signaling pathway	68
Soluble LDL-receptor is induced by TNF-α and inhibits hepatocytic clearance of LDL-cholesterol	67
Metabolomics reveals that chronic restraint stress alleviates carbon tetrachloride-induced hepatic fibrosis through the INSR/PI3K/AKT/AMPK pathway	64
Eucalyptol induces osteoblast differentiation through ERK phosphorylation in vitro and in vivo	62
Retraction Note: Endothelin-1 induces the transactivation of vascular endothelial growth factor receptor-3 and modulates cell migration and vasculogenic mimicry in melanoma cells	60
Glycosylation is a key in SARS-CoV-2 infection	58
Mitochondrial transplantation as a possible therapeutic option for sarcopenia	55
The role of CD146 in renal disease: from experimental nephropathy to clinics	50
Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinoma	48
Sex hormone binding globulin (SHBG) modulates mitochondrial dynamics in PPARγ-depleted equine adipose derived stromal cells	44
PCDH11X mutation as a potential biomarker for immune checkpoint therapies in lung adenocarcinoma	37
Protective role of M3 muscarinic acetylcholine receptor in indomethacin-induced small intestinal injury	36
Removal of GIT lesions and the role of impedance of the injection solution—an innovative approach to known methods	35
The mutual interplay of redox signaling and connexins	34
Analysis of the action mechanisms and targets of herbal anticonvulsants highlights opportunities for therapeutic engagement with refractory epilepsy	34
Nrf2 as a potential target for Parkinson’s disease therapy	33
I536T variant of RBM20 affects splicing of cardiac structural proteins that are causative for developing dilated cardiomyopathy	33
A novel ceRNA regulatory network involving the long noncoding NEAT1, miRNA-466f-3p and its mRNA target in osteoblast autophagy and osteoporosis	33
X-linked genes exhibit skewed expression in Sjogren’s disease (SjD): a further step toward understanding the female predominance of autoimmune disease	30
Pathogenic effects of Leu200Pro and Arg387His VRK1 protein variants on phosphorylation targets and H4K16 acetylation in distal hereditary motor neuropathy	29
IGFBP2 function as a novel biomarker for active lupus nephritis	29
Loss-of-function mutation in DDX53 associated with hereditary spastic paraplegia-like disorder	29
Acyloxyacyl hydrolase deficiency induces chronic inflammation and bone loss in male mice	28
Histone modification in podocyte injury of diabetic nephropathy	27

ABCB1 in dermatology: roles in skin diseases and their treatment	27
Unleashing the power of NK cells in anticancer immunotherapy	26
The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration	26
Correction to: The recurrent missense mutation p.(Arg367Trp) in YARS1 causes a distinct neurodevelopmental phenotype	26
WWOX and metabolic regulation in normal and pathological conditions	26
Potential role of mesenchymal stem cells in T cell aging	25
Identification of STAT3 and MYC as critical ferroptosis-related biomarkers in septic cardiomyopathy: a bioinformatics and experimental study	25
Knockdown of SOX9 alleviates tracheal fibrosis through the Wnt/β-catenin signaling pathway	24
Increased Fusobacterium tumoural abundance affects immunogenicity in mucinous colorectal cancer and may be associated with improved clinical outcome	24
Identification of the regulatory mechanism of ACE2 in COVID-19–induced kidney damage with systems genetics approach	24
JAK2 regulates paclitaxel resistance in triple negative breast cancers	22
Post-infarction cardiac remodeling—differential biomarkers for left atrial and left ventricular remodeling	21
Correction to: The protean world of non-coding RNAs in glioblastoma	21
Silencing of Mcl-1 overcomes resistance of melanoma cells against TRAIL-armed oncolytic adenovirus by enhancement of apoptosis	21
Diminished miR-374c-5p negatively regulates IL (interleukin)-6 in unexplained recurrent spontaneous abortion	21
Loss of CAA interruption and intergenerational CAG instability in Chinese patients with Huntington’s disease	21
Novel high-yield potato protease inhibitor panels block a wide array of proteases involved in viral infection and crucial tissue damage	21
X-linked genes exhibit miR6891-5p-regulated skewing in Sjögren’s syndrome	21
The role of immunosuppressive myofibroblasts in the aging process and age-related diseases	20
Synthetic polypeptide crotamine: characterization as a myotoxin and as a target of combinatorial peptides	20
A simple tool for evaluation of inflammation in psoriasis: Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio as markers in psoriasis patients and related murine models of psoriasis-like skin d	20
IL-23 contributes to Particulate Matter induced allergic asthma in the early life of mice and promotes asthma susceptibility	20
CD27 expression on Treg cells limits immune responses against tumors	20
Neurovascular abnormalities in retinopathy of prematurity and emerging therapies	20
The PER3rs772027021 SNP induces pigmentation phenotypes of dyschromatosis universalis hereditaria	19
Indole-3-Aldehyde alleviates lung inflammation in COPD through activating Aryl Hydrocarbon Receptor to inhibit HDACs/NF-κB/NLRP3 signaling pathways	19
Identification of PDXDC1 as a novel pleiotropic susceptibility locus shared between lumbar spine bone mineral density and birth weight	19
Correction to: The vasculature niches required for hematopoiesis	19
Suppression of PGE2/EP2 signaling alleviates Hirschsprung disease by upregulating p38 mitogen-activated protein kinase activity	19
Nets, pulmonary arterial hypertension, and thrombo-inflammation	19
Advances in gene therapy for neurogenetic diseases: a brief review	18
Sympathetic nerve-adipocyte interactions in response to acute stress	18
Molecular mechanisms of thalidomide effectiveness on COVID-19 patients explained: ACE2 is a new ΔNp63α target gene	17
Preferential expression of SCN1A in GABAergic neurons improves survival and epileptic phenotype in a mouse model of Dravet syndrome	17
Effect of α7 nAChR-autophagy axis of deciduous tooth pulp stem cells in regulating IL-1β in the process of physiological root resorption of deciduous teeth	17
Nicotinamide riboside kinase-2 regulates metabolic adaptation in the ischemic heart	17
The role and mechanism of heme oxygenase-1 in arrhythmias	17
Biochemical and structural characterization of beta-carbonic anhydrase from the parasite Trichomonas vaginalis	16
The caspase-inhibitor Emricasan efficiently counteracts cisplatin- and neomycin-induced cytotoxicity in cochlear cells	16
Recent updates on targeting the molecular mediators of NAFLD	16
Soluble IL-6R-mediated IL-6 trans-signaling activation contributes to the pathological development of psoriasis	16
Longitudinal study on immunologic, lipoproteomic, and inflammatory responses indicates the safety of sequential COVID-19 vaccination	16
An innovative targeted therapy for fluoroscopy-induced chronic radiation dermatitis	15
PARP2 promotes inflammation in psoriasis by modulating estradiol biosynthesis in keratinocytes	15
Liquid–liquid phase separation in Alzheimer’s disease	15
PD-1/PD-L1 axis: implications in immune regulation, cancer progression, and translational applications	15
Multiple sclerosis is linked to MAPKERK overactivity in microglia	15
SAMHD1 in cancer: curse or cure?	15
Cellular localization of nucleolin determines the prognosis in cancers: a meta-analysis	15
Melatonin inhibits senescence-associated melanin pigmentation through the p53-TYR pathway in human primary melanocytes and the skin of C57BL/6 J mice after UVB irradiation	15

LMO3 reprograms visceral adipocyte metabolism during obesity	15
Non-invasive biomarkers prognostic of decompensation events in NASH cirrhosis: a systematic literature review	14
Gaucher disease – more than just a rare lipid storage disease	14
Mechanism of efferocytosis in atherosclerosis	14
MyD88 in hepatic stellate cells promotes the development of alcoholic fatty liver via the AKT pathway	13
The role of regulated necrosis in diabetes and its complications	13
Novel insights into the nervous system affected by prolonged hyperglycemia	13
Modelling of BCS1L-related human mitochondrial disease in Drosophila melanogaster	13
Exploring the role of tRNA-derived small RNAs (tsRNAs) in disease: implications for HIF-1 pathway modulation	13
Protective mechanisms of loquat leaf extract and ursolic acid against diabetic pro-inflammation	13
Inhibition of ERK/CREB signaling contributes to postoperative learning and memory dysfunction in neonatal rats	12
FATP1-mediated fatty acid uptake in renal tubular cells as a countermeasure for hypothermia	12
GSK-3α aggravates inflammation, metabolic derangement, and cardiac injury post-ischemia/reperfusion	12
The diagnostic potential of a circRNA–miRNA network in non-small cell lung cancer	12
Aging- and alcohol-associated spatial transcriptomic signature in mouse acute pancreatitis reveals heterogeneity of inflammation and potential pathogenic factors	12
Etiopathogenesis of medication-related osteonecrosis of the jaws: a review	12
Apamin inhibits renal fibrosis via suppressing TGF-β1 and STAT3 signaling in vivo and in vitro	12
Dissecting the role of cell signaling versus CD8+ T cell modulation in propranolol antitumor activity	12
Human colorectal cancer-associated carbohydrate antigen on annexin A2 protein	12
SMARCC1 promotes M2 macrophage polarization and reduces ferroptosis in lung cancer by activating FLOT1 transcription	12
Circular RNAs: regulators of vascular smooth muscle cells in cardiovascular diseases	12
Structure-based humanization of a therapeutic antibody for multiple myeloma	12
The oncogenic role of EIF4A3/CDC20 axis in the endometrial cancer	11
Modulation of cellular transcriptome and proteome composition by azidohomoalanine—implications on click chemistry–based secretome analysis	11
The TLR/MyD88 signalling cascade in inflammation and gastric cancer: the immune regulatory network of Helicobacter pylori	11
Metformin improves cognitive dysfunction through SIRT1/NLRP3 pathway–mediated neuroinflammation in db/db mice	11
The recurrent missense mutation p.(Arg367Trp) in YARS1 causes a distinct neurodevelopmental phenotype	11
Valproic acid modulates collagen architecture in the postoperative conjunctival scar	11
Aquaporin-4 prevents exaggerated astrocytosis and structural damage in retinal inflammation	11
LAMP2A regulates the balance of mesenchymal stem cell adipo-osteogenesis via the Wnt/β-catenin/GSK3β signaling pathway	11
The interplay of DAMPs, TLR4, and proinflammatory cytokines in pulmonary fibrosis	10
c-Met up-regulates the expression of PD-L1 through MAPK/NF-κBp65 pathway	10
Increased uterine androgen receptor protein abundance results in implantation and mitochondrial defects in pregnant rats with hyperandrogenism and insulin resistance	10
Expression of PKM2 in wound keratinocytes is coupled to angiogenesis during skin repair in vivo and in HaCaT keratinocytes in vitro	10
PBX1: a key character of the hallmarks of cancer	10
Microdevices for cancer stem cell culture as a predictive chemotherapeutic response platform	10
Correction to: Arginine derivatives in atrial fibrillation progression phenotypes	10
Interleukin-23 instructs protective multifunctional CD4 T cell responses after immunization with the Mycobacterium tuberculosis subunit vaccine H1 DDA/TDB independently of interleukin-17A	10
Circulating tumor cells in colorectal cancer in the era of precision medicine	10
CREB-H is a stress-regulator of hepcidin gene expression during early postnatal development	9
Altered expression of Sialyl Lewis X in experimental models of Parkinson’s disease	9
Leukocyte cytokine responses in adult patients with mitochondrial DNA defects	9
TFEB: a double-edged sword for tumor metastasis	9
TGF-β1/Smad3 upregulates UCA1 to promote liver fibrosis through DKK1 and miR18a	9
The osteoporosis susceptibility SNP rs188303909 at 2q14.2 regulates EN1 expression by modulating DNA methylation and E2F6 binding	9
Inhibition of p38 MAPK decreases hyperglycemia-induced nephrin endocytosis and attenuates albuminuria	9
Long noncoding RNA HAR1A regulates oral cancer progression through the alpha-kinase 1, bromodomain 7, and myosin IIA axis	9
Genotypic analysis of a large cohort of patients with suspected atypical hemolytic uremic syndrome	9
Mitochondrial respiration inhibitor enhances the anti-tumor effect of high-dose ascorbic acid in castration-resistant prostate cancer	9
Synergistic effect of the sphingosine kinase inhibitor safingol in combination with 2'-nitroflavone in breast cancer	9
Possible implication of miR-142-3p in coronary microembolization induced myocardial injury via ATXN1L/HDAC3/NOL3 axis	9
Regulation of wound healing and fibrosis by galectins	9
PAX5 aberrant expression incorporated in MIPI-SP risk scoring system exhibits additive value in mantle cell lymphoma	9
Aging whole blood transcriptome reveals candidate genes for SARS-CoV-2-related vascular and immune alterations	9