OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Molecular Medicine-Jmm is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Vascular pathologies in chronic kidney disease: pathophysiological mechanisms and novel therapeutic approaches	86
Increased immunosuppression impairs tissue homeostasis with aging and age-related diseases	62
The acidic tumor microenvironment drives a stem-like phenotype in melanoma cells	55
Cancer research using organoid technology	51
Glycosylation is a key in SARS-CoV-2 infection	50
The interplay of DAMPs, TLR4, and proinflammatory cytokines in pulmonary fibrosis	46
Organoids of the female reproductive tract	45
AMPK: a key regulator of energy stress and calcium-induced autophagy	45
Disturbed lipid and amino acid metabolisms in COVID-19 patients	45
SCFAs induce autophagy in intestinal epithelial cells and relieve colitis by stabilizing HIF-1α	44
Expanding and validating the biomarkers for mitochondrial diseases	44
Endocrine resistance in breast cancer: from molecular mechanisms to therapeutic strategies	44
A comprehensive review of genetic alterations and molecular targeted therapies for the implementation of personalized medicine in acute myeloid leukemia	43
Evolving AAV-delivered therapeutics towards ultimate cures	42
Obesity and its impact on COVID-19	41
Immunosuppressive network promotes immunosenescence associated with aging and chronic inflammatory conditions	41
COVID-19: molecular diagnostics overview	41
Mitochondrial respiratory supercomplexes in mammalian cells: structural versus functional role	38
Insights into the biased activity of dextromethorphan and haloperidol towards SARS-CoV-2 NSP6: in silico binding mechanistic analysis	36
Lysosomal storage diseases: current therapies and future alternatives	35
Extracellular vesicles-associated tRNA-derived fragments (tRFs): biogenesis, biological functions, and their role as potential biomarkers in human diseases	35
Premature ovarian insufficiency: pathogenesis and therapeutic potential of mesenchymal stem cell	35
Novel therapeutic approaches for treatment of COVID-19	34
Genetic engineering in organoids	34
The heterodimer S100A8/A9 is a potent therapeutic target for idiopathic pulmonary fibrosis	34

Diagnosing the novel SARS-CoV-2 by quantitative RT-PCR: variations and opportunities	34
The human coronaviruses (HCoVs) and the molecular mechanisms of SARS-CoV-2 infection	33
High glucose: an emerging association between diabetes mellitus and cancer progression	33
Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1β and IL-17 upregul	32
ACE polymorphisms and COVID-19-related mortality in Europe	32
Role of the IL-2 inducible tyrosine kinase ITK and its inhibitors in disease pathogenesis	31
TCF21: a critical transcription factor in health and cancer	31
NLRP3 inflammasome priming and activation in cholestatic liver injury via the sphingosine 1-phosphate/S1P receptor 2/Gα(12/13)/MAPK signaling pathway	30
Memantine in neurological disorders – schizophrenia and depression	29
Non-coding RNAs regulating mitochondrial function in cardiovascular diseases	29
High levels of extracellular ATP lead to different inflammatory responses in COVID-19 patients according to the severity	28
Immuno-epidemiology and pathophysiology of coronavirus disease 2019 (COVID-19)	28
Microglial-specific depletion of TAK1 is neuroprotective in the acute phase after ischemic stroke	28
Oxidized LDL induces vimentin secretion by macrophages and contributes to atherosclerotic inflammation	28
Abnormalities of synaptic mitochondria in autism spectrum disorder and related neurodevelopmental disorders	27
Transporter associated with antigen processing 1 (TAP1) expression and prognostic analysis in breast, lung, liver, and ovarian cancer	27
Mitochondrial dynamics and its impact on human health and diseases: inside the DRP1 blackbox	24
Multiple sclerosis is linked to MAPKERK overactivity in microglia	24
CD27 expression on Treg cells limits immune responses against tumors	24
P2X7 receptor: a critical regulator and potential target for breast cancer	23
The FOXO family of transcription factors: key molecular players in gastric cancer	23
Nrf2 as a potential target for Parkinson’s disease therapy	23
hPSC-derived organoids: models of human development and disease	22
Wnt signaling in kidney: the initiator or terminator?	22
The anti-inflammatory drug dimethyl itaconate protects against colitis-associated colorectal cancer	22
Lipid accumulation and novel insight into vascular smooth muscle cells in atherosclerosis	22
Corticosteroid enhances epithelial barrier function in intestinal organoids derived from patients with Crohn’s disease	22
Eukaryotic elongation factor-2 kinase (eEF2K) signaling in tumor and microenvironment as a novel molecular target	21
Increased uterine androgen receptor protein abundance results in implantation and mitochondrial defects in pregnant rats with hyperandrogenism and insulin resistance	21
Current and future direction in treatment of HPV-related cervical disease	21
Impact of β-glycerophosphate on the bioenergetic profile of vascular smooth muscle cells	21
Clinical perspectives on the age-related increase of immunosuppressive activity	20
Cooperative signaling between integrins and growth factor receptors in fibrosis	20
NLRP6 contributes to inflammation and brain injury following intracerebral haemorrhage by activating autophagy	20
Toll-interacting protein impacts on inflammation, autophagy, and vacuole trafficking in human disease	19
Pharmacological blockage of the AHR-CYP1A1 axis: a call for in vivo evidence	19
The ethics of human-embryoids model: a call for consistency	19
3D kidney organoids for bench-to-bedside translation	19
Activation of aryl hydrocarbon receptor (AhR) in Alzheimer’s disease: role of tryptophan metabolites generated by gut host-microbiota	18
An update to “novel therapeutic approaches for treatment of COVID-19”	18
In vivo optical molecular imaging of inflammation and immunity	18
Evaluation of EpCAM-specific exosomal lncRNAs as potential diagnostic biomarkers for lung cancer using droplet digital PCR	18
JAK2 regulates paclitaxel resistance in triple negative breast cancers	18
Neuroprotective and antioxidative effects of pioglitazone in brain tissue adjacent to the ischemic core are mediated by PI3K/Akt and Nrf2/ARE pathways	18
Differential regulation of osteopontin and CD44 correlates with infertility status in PCOS patients	18
Epigenetic modifications of Klotho expression in kidney diseases	17
Exploring the VISTA of microglia: immune checkpoints in CNS inflammation	17
Dysregulation of circRNA expression in the peripheral blood of individuals with schizophrenia and bipolar disorder	17
Chronic stress promotes acute myeloid leukemia progression through HMGB1/NLRP3/IL-1β signaling pathway	17
Aging whole blood transcriptome reveals candidate genes for SARS-CoV-2-related vascular and immune alterations	17

Lipid metabolism, inflammation, and foam cell formation in health and metabolic disorders: targeting mTORC1	17
RNA sequencing reveals BMP4 as a basis for the dual-target treatment of diabetic retinopathy	17
Somatic non-cancerous PIK3CA-related overgrowth syndrome treated with alpelisib in North America	16
The transrepression and transactivation roles of CtBPs in the pathogenesis of different diseases	16
Oviduct as a sensor of embryo quality: deciphering the extracellular vesicle (EV)-mediated embryo-maternal dialogue	16
Soluble IL-6R-mediated IL-6 trans-signaling activation contributes to the pathological development of psoriasis	16
PBX1: a key character of the hallmarks of cancer	16
CU06-1004 (endothelial dysfunction blocker) ameliorates astrocyte end-feet swelling by stabilizing endothelial cell junctions in cerebral ischemia/reperfusion injury	15
Epigenetic mechanisms regulate sex-specific bias in disease manifestations	15
LKB1-PTEN axis controls Th1 and Th17 cell differentiation via regulating mTORC1	15
Underlying mechanisms of epithelial splicing regulatory proteins in cancer progression	15
Need for a precise molecular diagnosis in Beckwith-Wiedemann and Silver-Russell syndrome: what has to be considered and why it is important	15
Chemically modified curcumin (CMC2.24) alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis	15
Regional specification and complementation with non-neuroectodermal cells in human brain organoids	15
The herbal extract EPs® 7630 increases the antimicrobial airway defense through monocyte-dependent induction of IL-22 in T cells	15
Expression and function of Smad7 in autoimmune and inflammatory diseases	15
Phenotypic characteristics of commonly used inbred mouse strains	15
TNFSF13 upregulation confers chemotherapeutic resistance via triggering autophagy initiation in triple-negative breast cancer	14
Endogenous cortisol excess confers a unique lipid signature and metabolic network	14
Gaucher disease – more than just a rare lipid storage disease	14
Gastrointestinal epithelial innate immunity—regionalization and organoids as new model	14
Selective blood-nerve barrier leakiness with claudin-1 and vessel-associated macrophage loss in diabetic polyneuropathy	14
ABCB1 in dermatology: roles in skin diseases and their treatment	14
Relevance of iNOS expression in tumor growth and maintenance of cancer stem cells in a bladder cancer model	14
MT1 and MT2 melatonin receptors play opposite roles in brain cancer progression	14
Long noncoding RNA HAR1A regulates oral cancer progression through the alpha-kinase 1, bromodomain 7, and myosin IIA axis	13
HMGB1: an important regulator of myeloid differentiation and acute myeloid leukemia as well as a promising therapeutic target	13
Mixed lineage kinase domain-like pseudokinase-mediated necroptosis aggravates periodontitis progression	13
Circulating tumor cells in colorectal cancer in the era of precision medicine	13
ZMIZ proteins: partners in transcriptional regulation and risk factors for human disease	13
NF-κB in control of regulatory T cell development, identity, and function	13
SAMHD1 in cancer: curse or cure?	13
Metabolism of N-nitrosodimethylamine, methylation of macromolecules, and development of hepatic fibrosis in rodent models	13
Critical role of HOX transcript antisense intergenic RNA (HOTAIR) in gliomas	13
Purinergic signaling elements are correlated with coagulation players in peripheral blood and leukocyte samples from COVID-19 patients	12
Energy substrate metabolism and oxidative stress in metabolic cardiomyopathy	12
Associations of TP53 codon 72 polymorphism with complications and comorbidities in patients with type 1 diabetes	12
White and brown adipose tissue functionality is impaired by fine particulate matter (PM2.5) exposure	12
Pyruvate dehydrogenase kinase/lactate axis: a therapeutic target for neovascular age-related macular degeneration identified by metabolomics	12
Microparticles expressing myeloperoxidase as potential biomarkers in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV)	12
Role of Na+/K+-ATPase in ischemic stroke: in-depth perspectives from physiology to pharmacology	12
Histone deacetylase 3 (HDAC3) as an important epigenetic regulator of kidney diseases	12
A coordinated approach for the assessment of molecular subgroups in pediatric ependymomas using low-cost methods	12
Autotaxin stimulates LPA2 receptor in macrophages and exacerbates dextran sulfate sodium-induced acute colitis	12
Roles of E3 ubiquitin ligases in gastric cancer carcinogenesis and their effects on cisplatin resistance	12
Mucosal immunity and tRNA, tRF, and tiRNA	12
Bone marrow adiposity during pathologic bone loss: molecular mechanisms underlying the cellular events	12
Apamin inhibits renal fibrosis via suppressing TGF-β1 and STAT3 signaling in vivo and in vitro	12
Gut microbiota and atherosclerosis: role of B cell for atherosclerosis focusing on the gut-immune-B2 cell axis	11
Urinary metabolic signatures reflect cardiovascular risk in the young, middle-aged, and elderly populations	11
Regulation of tamoxifen sensitivity by the PLAC8/MAPK pathway axis is antagonized by curcumin-induced protein stability change	11
Stem cell therapies for retinal diseases: from bench to bedside	11
Exploring the link between chronobiology and drug delivery: effects on cancer therapy	11
Biophysical and pharmacological characterization of a full-length synthetic analog of the antitumor polypeptide crotamine	11
Fibulin-3 knockout mice demonstrate corneal dysfunction but maintain normal retinal integrity	11
Insulin-mediated immune dysfunction in the development of preeclampsia	11
Critical roles of macrophages in pressure overload-induced cardiac remodeling	11
Revisiting lactate dynamics in cancer—a metabolic expertise or an alternative attempt to survive?	11
Unleashing the power of NK cells in anticancer immunotherapy	11