Development

Article	Citations
The extracellular matrix in development	211
Mechanisms of human embryo development: from cell fate to tissue shape and back	113
The lateral plate mesoderm	93
Principles and mechanisms of asymmetric cell division	83
Retinal organoids: a window into human retinal development	82
Development of the cochlea	72
A single-cell atlas of mouse lung development	70
Single-cell transcriptome profiling of the human developing spinal cord reveals a conserved genetic programme with human-specific features	69
Bioelectric signaling as a unique regulator of development and regeneration	67
Understanding axial progenitor biology in vivo and in vitro	64
The molecular and cellular features of 2-cell-like cells: a reference guide	63
Branching morphogenesis	60
Neuronal and glial regulation of CNS angiogenesis and barriergenesis	57
Tissue-resident macrophages regulate lymphatic vessel growth and patterning in the developing heart	57
Stem cell quiescence: the challenging path to activation	57
Establishing the pattern of the vertebrate limb	52
Characterization of primary models of human trophoblast	50
Germline sexual fate is determined by the antagonistic action of dmrt1 and foxl3/foxl2 in tilapia	50
Mechanisms of heart valve development and disease	47
From pluripotency to totipotency: an experimentalist's guide to cellular potency	47
Axial elongation of caudalized human organoids mimics aspects of neural tube development	46
Mammary development in the embryo and adult: new insights into the journey of morphogenesis and commitment	46
Normal Table of Xenopus development: a new graphical resource	44
Development of a straight vertebrate body axis	44
Orchestrating morphogenesis: building the body plan by cell shape changes and movements	44

The heart of the neural crest: cardiac neural crest cells in development and regeneration	43
Segmentation and patterning of the vertebrate hindbrain	43
Transcriptional adaptation: a mechanism underlying genetic robustness	42
TGFβ family signaling and development	42
Cyclical endometrial repair and regeneration	41
Mammalian primordial germ cell specification	41
Cell trajectory modeling identifies a primitive trophoblast state defined by BCAM enrichment	40
The many bits of positional information	39
Development and plasticity of the corpus callosum	39
WNT signaling in pre-granulosa cells is required for ovarian folliculogenesis and female fertility	39
GFI1 functions to repress neuronal gene expression in the developing inner ear hair cells	38
TEAD family transcription factors in development and disease	38
A single cell RNA sequencing resource for early sea urchin development	37
Using Drosophila to drive the diagnosis and understand the mechanisms of rare human diseases	37
Neural crest lineage analysis: from past to future trajectory	37
Arabidopsis root responses to salinity depend on pectin modification and cell wall sensing	37
Y705 and S727 are required for the mitochondrial import and transcriptional activities of STAT3, and for regulation of stem cell proliferation	37
Stochasticity and determinism in cell fate decisions	36
The pulse of morphogenesis: actomyosin dynamics and regulation in epithelia	36
CNS macrophages differentially rely on an intronicCsf1renhancer for their development	35
Hybridization chain reaction enables a unified approach to multiplexed, quantitative, high-resolution immunohistochemistry and in situ hybridization	35
What determines organ size during development and regeneration?	35
Precision of tissue patterning is controlled by dynamical properties of gene regulatory networks	35
Dynamic extrinsic pacing of the HOX clock in human axial progenitors controls motor neuron subtype specification	35
Developmental single-cell transcriptomics in the Lytechinus variegatus sea urchin embryo	34
Hallmarks of intestinal stem cells	34
Pluripotent stem cells related to embryonic disc exhibit common self-renewal requirements in diverse livestock species	34
Mechanical feedback-loop regulation of morphogenesis in plants	34
MOrgAna: accessible quantitative analysis of organoids with machine learning	33
The multiple facets of Cajal-Retzius neurons	33
Single-cell transcriptomics of the early developing mouse cerebral cortex disentangle the spatial and temporal components of neuronal fate acquisition	32
Insulin/IGF signaling and TORC1 promote vitellogenesis via inducing juvenile hormone biosynthesis in the American cockroach	32
Understanding angiodiversity: insights from single cell biology	31
Phyllotaxis as geometric canalization during plant development	31
Common principles of early mammalian embryo self-organisation	31
lncRNAs in development and differentiation: from sequence motifs to functional characterization	31
Tissue clearing and 3D imaging in developmental biology	30
Deep learning for bioimage analysis in developmental biology	30
Dynamic profiling and functional interpretation of histone lysine crotonylation and lactylation during neural development	30
Circular RNAs in cell differentiation and development	30
Hedgehog signaling and the primary cilium: implications for spatial and temporal constraints on signaling	29
The combined action of Esrrb and Nr5a2 is essential for murine naïve pluripotency	29
Spatiotemporal sequence of mesoderm and endoderm lineage segregation during mouse gastrulation	29
Gene-environment interactions: aligning birth defects research with complex etiology	29
Sculpting with stem cells: how models of embryo development take shape	29
HY5 and phytochrome activity modulate shoot-to-root coordination during thermomorphogenesis in Arabidopsis	29
Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse	28
Combinatorial patterns of graded RhoA activation and uniform F-actin depletion promote tissue curvature	28
A landmark-free morphometrics pipeline for high-resolution phenotyping: application to a mouse model of Down syndrome	28
The origins and roles of osteoclasts in bone development, homeostasis and repair	28

Stem cells in pulmonary alveolar regeneration	28
Nuclear pore complexes in development and tissue homeostasis	27
Zebrafish dazl regulates cystogenesis and germline stem cell specification during the primordial germ cell to germline stem cell transition	27
Human assembloids	26
The complex three-dimensional organization of epithelial tissues	26
Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds	26
Inferring cell junction tension and pressure from cell geometry	25
CFAP61 is required for sperm flagellum formation and male fertility in human and mouse	25
Single-nuclei transcriptome analysis of the shoot apex vascular system differentiation in Populus	25
The road to generating transplantable organs: from blastocyst complementation to interspecies chimeras	25
Assisted reproductive technologies induce temporally specific placental defects and the preeclampsia risk marker sFLT1 in mouse	25
The origin and mechanisms of smooth muscle cell development in vertebrates	24
Mechanical and signaling mechanisms that guide pre-implantation embryo movement	24
The development and stem cells of the esophagus	24
FaceBase 3: analytical tools and FAIR resources for craniofacial and dental research	24
The ECM as a driver of heart development and repair	24
Gut innervation and enteric nervous system development: a spatial, temporal and molecular tour de force	24
Gene expression variation in Arabidopsis embryos at single-nucleus resolution	24
Development of the mammalian main olfactory bulb	24
Cell death in animal development	24
Evidence of two types of balance between stem cell mitosis and enterocyte nucleus growth in the Drosophila midgut	24
Cell-cell communication through FGF4 generates and maintains robust proportions of differentiated cell types in embryonic stem cells	24
The HK5 and HK6 cytokinin receptors mediate diverse developmental pathways in rice	24
Distinct contributions of ECM proteins to basement membrane mechanical properties in Drosophila	23
Transposable elements, circular RNAs and mitochondrial transcription in age-related genomic regulation	23
Hes1 overexpression leads to expansion of embryonic neural stem cell pool and stem cell reservoir in the postnatal brain	23
Asynchrony of ovule primordia initiation in Arabidopsis	23
Loss of perinuclear theca ACTRT1 causes acrosome detachment and severe male subfertility in mice	23
Ceramides mediate positional signals in Arabidopsis thaliana protoderm differentiation	22
Integrated molecular analysis identifies a conserved pericyte gene signature in zebrafish	22
Evolution and development of complex eyes: a celebration of diversity	22
New trends in cellular therapy	22
Prrx1b restricts fibrosis and promotes Nrg1-dependent cardiomyocyte proliferation during zebrafish heart regeneration	22
Self-organized cell migration across scales – from single cell movement to tissue formation	22
Retinal ganglion cell interactions shape the developing mammalian visual system	22
Single-cell morphometrics reveals ancestral principles of notochord development	21
Mosaic CRISPR-stop enables rapid phenotyping of nonsense mutations in essential genes	21
Wnt/beta-catenin signalling is dispensable for adult neural stem cell homeostasis and activation	21
Cyclical fate restriction: a new view of neural crest cell fate specification	21
Fibroblast growth factor 10 is a negative regulator of postnatal neurogenesis in the mouse hypothalamus	21
From head to tail: regionalization of the neural crest	21
Developmental mechanisms of sex differences: from cells to organisms	21
Polyploid cardiomyocytes: implications for heart regeneration	21
Development and maintenance of tendons and ligaments	21
ERECTA family signaling constrains CLAVATA3 and WUSCHEL to the center of the shoot apical meristem	21
Deficiency and overexpression of Rtl1 in the mouse cause distinct muscle abnormalities related to Temple and Kagami-Ogata syndromes	21
Model systems for regeneration:Arabidopsis	20
Quantitative developmental biology in vitro using micropatterning	20
Microglia in brain development and regeneration	20
SCARECROW is deployed in distinct contexts during rice and maize leaf development	20
Enhancer-gene specificity in development and disease	20
Secreted inhibitors drive the loss of regeneration competence in Xenopus limbs	20
The biomechanical basis of biased epithelial tube elongation in lung and kidney development	19
APETALA2 functions as a temporal factor together with BLADE-ON-PETIOLE2 and MADS29 to control flower and grain development in barley	19
Identification of regulatory elements required for Stra8 expression in fetal ovarian germ cells of the mouse	19
Aster repulsion drives short-ranged ordering in the Drosophila syncytial blastoderm	19
Gynoecium and fruit development in Arabidopsis	19
The alx3 gene shapes the zebrafish neurocranium by regulating frontonasal neural crest cell differentiation timing	19
Diversity and robustness of bone morphogenetic protein pattern formation	19
Fluid flow as a driver of embryonic morphogenesis	19
Knock-in tagging in zebrafish facilitated by insertion into non-coding regions	19
Three-axis classification of mouse lung mesenchymal cells reveals two populations of myofibroblasts	19
Regulatory mechanisms governing epidermal stem cell function during development and homeostasis	18
Germ cell determination and the developmental origin of germ cell tumors	18
The mechanosensitive channel Piezo1 cooperates with semaphorins to control neural crest migration	18
Robustness and timing of cellular differentiation through population-based symmetry breaking	18
Stable iPSC-derived NKX2-1+ lung bud tip progenitor organoids give rise to airway and alveolar cell types	18
Intermittent ERK oscillations downstream of FGF in mouse embryonic stem cells	18
High temperature perception in leaves promotes vascular regeneration and graft formation in distant tissues	18
Defining the signalling determinants of a posterior ventral spinal cord identity in human neuromesodermal progenitor derivatives	18
Immune cells in cardiac repair and regeneration	18
The Drosophila ribosome protein S5 paralog RpS5b promotes germ cell and follicle cell differentiation during oogenesis	18
Maintenance DNA methylation in pre-meiotic germ cells regulates meiotic prophase by facilitating homologous chromosome pairing	17
Metaphloem development in the Arabidopsis root tip	17
A combination of Notch signaling, preferential adhesion and endocytosis induces a slow mode of cell intercalation in the Drosophila retina	17
Cell cycle control during early embryogenesis	17
CCDC38 is required for sperm flagellum biogenesis and male fertility in mice	17
The extracellular matrix protein agrin is essential for epicardial epithelial-to-mesenchymal transition during heart development	17
Biology of resident tissue macrophages	17
What machine learning can do for developmental biology	17

Shedding light on developmental ERK signaling with genetically encoded biosensors	17
Msl3 promotes germline stem cell differentiation in female Drosophila	17
Protein manipulation using single copies of short peptide tags in cultured cells and in Drosophila melanogaster	17
Human embryo implantation	17
Building neuromuscular junctions in vitro	17
Towards understanding the origin of animal development	17
Cell state transitions: definitions and challenges	17
Premeiotic endoreplication is essential for obligate parthenogenesis in geckos	17
An L-type lectin receptor-like kinase promotes starch accumulation during rice pollen maturation	17
A single-cell atlas of de novo β-cell regeneration reveals the contribution of hybrid β/δ-cells to diabetes recovery in zebrafish	16
Paternal MTHFR deficiency leads to hypomethylation of young retrotransposons and reproductive decline across two successive generations	16
Enhancer RNAs step forward: new insights into enhancer function	16
longfin causes cis-ectopic expression of the kcnh2a ether-a-go-go K+ channel to autonomously prolong fin outgrowth	16
Cell type-specific dynamics underlie cellular growth variability in plants	16
The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development	16
Age reprogramming: cell rejuvenation by partial reprogramming	16
Thymosin β4 is essential for adherens junction stability and epidermal planar cell polarity	16
C2CD6 regulates targeting and organization of the CatSper calcium channel complex in sperm flagella	16
Deep learning is widely applicable to phenotyping embryonic development and disease	16
FGF signalling plays similar roles in development and regeneration of the skeleton in the brittle star Amphiura filiformis	16
FOXO1 mediates hypoxia-induced G0/G1 arrest in ovarian somatic granulosa cells by activating the TP53INP1-p53-CDKN1A pathway	16
Sequestration to lipid droplets promotes histone availability by preventing turnover of excess histones	15
Lipid metabolism in focus: how the build-up and breakdown of lipids affects stem cells	15
Development of vascular regulation in the zebrafish embryo	15
Loss of Prm1 leads to defective chromatin protamination, impaired PRM2 processing, reduced sperm motility and subfertility in male mice	15
Avian auditory hair cell regeneration is accompanied by JAK/STAT-dependent expression of immune-related genes in supporting cells	15
Rectified random cell motility as a mechanism for embryo elongation	15
Functional evidence that Activin/Nodal signaling is required for establishing the dorsal-ventral axis in the annelid Capitella teleta	15
The initiation knot is a signaling center required for molar tooth development	15
DPPA2 and DPPA4 are dispensable for mouse zygotic genome activation and pre-implantation development	15
Hypoxia induces an early primitive streak signature, enhancing spontaneous elongation and lineage representation in gastruloids	15
The origin and role of the renal stroma	15
Calcium and activity-dependent signaling in the developing cerebral cortex	15
Dlx1/2-dependent expression of Meis2 promotes neuronal fate determination in the mammalian striatum	15
KATNB1 is a master regulator of multiple katanin enzymes in male meiosis and haploid germ cell development	15
Ciona embryonic tail bending is driven by asymmetrical notochord contractility and coordinated by epithelial proliferation	15
INO80 requires a polycomb subunit to regulate the establishment of poised chromatin in murine spermatocytes	15
Imaging the onset of oscillatory signaling dynamics during mouse embryo gastrulation	15
Fis1 ablation in the male germline disrupts mitochondrial morphology and mitophagy, and arrests spermatid maturation	15
In vitro models of the human heart	15
Single-molecule tracking technologies for quantifying the dynamics of gene regulation in cells, tissue and embryos	15
Expansion and innovation in auxin signaling: where do we grow from here?	15
Identification of enhancer regulatory elements that direct epicardial gene expression during zebrafish heart regeneration	15
Proper timing of a quiescence period in precursor prospermatogonia is required for stem cell pool establishment in the male germline	14
Reprogramming cellular identity in vivo	14
Molecular and cellular architecture of the larval sensory organ in the cnidarian Nematostella vectensis	14
Visualizing polymeric components that define distinct root barriers across plant lineages	14
KLF17 promotes human naïve pluripotency but is not required for its establishment	14
Mural Wnt/β-catenin signaling regulates Lama2 expression to promote neurovascular unit maturation	14
Generation of a homozygous mutant drug transporter (ABCB1) knockout line in the sea urchinLytechinus pictus	14
Symbiosis: the other cells in development	14
Human pluripotent stem cell-derived kidney organoids for personalized congenital and idiopathic nephrotic syndrome modeling	14
The microRNA miR-202 prevents precocious spermatogonial differentiation and meiotic initiation during mouse spermatogenesis	14
Kinesin motor KIFC1 is required for tubulin acetylation and actin-dependent spindle migration in mouse oocyte meiosis	14
Toll signalling promotes blastema cell proliferation during cricket leg regeneration via insect macrophages	14
Initiation of Otx2 expression in the developing mouse retina requires a unique enhancer and either Ascl1 or Neurog2 activity	14
The Arabidopsis stomatal polarity protein BASL mediates distinct processes before and after cell division to coordinate cell size and fate asymmetries	14
The zebrafish issue: 25 years on	14
Focal adhesion-mediated cell anchoring and migration: from in vitro to in vivo	14
Hox genes in development and beyond	14
Human iPSC-derived cerebral organoids model features of Leigh syndrome and reveal abnormal corticogenesis	14
Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling	14
Notch signaling determines cell-fate specification of the two main types of vomeronasal neurons of rodents	14
An integrated atlas of human placental development delineates essential regulators of trophoblast stem cells	14
It takes all kinds: heterogeneity among satellite cells and fibro-adipogenic progenitors during skeletal muscle regeneration	13
Environmental oxygen regulates astrocyte proliferation to guide angiogenesis during retinal development	13
Mammalian tracheal development and reconstruction: insights from in vivo and in vitro studies	13
Defining epithelial-mesenchymal transitions in animal development	13
When form meets function: the cells and signals that shape the lymphatic vasculature during development	13
Exocrine gland structure-function relationships	13
Gene expression profiling of epidermal cell types in C. elegans using Targeted DamID	13
Agrin/Lrp4 signal constrains MuSK-dependent neuromuscular synapse development in appendicular muscle	13
Ethylene signaling increases reactive oxygen species accumulation to drive root hair initiation in Arabidopsis	13
Development of a 3D atlas of the embryonic pancreas for topological and quantitative analysis of heterologous cell interactions	13
Lmo7 recruits myosin II heavy chain to regulate actomyosin contractility and apical domain size in Xenopus ectoderm	13
Concerted morphogenesis of genital ridges and nephric ducts in the mouse captured through whole-embryo imaging	13
Sperm-borne miR-202 targets SEPT7 and regulates first cleavage of bovine embryos via cytoskeletal remodeling	13
SyNPL: Synthetic Notch pluripotent cell lines to monitor and manipulate cell interactions in vitro and in vivo	13
Understanding the role of lipids and lipoproteins in development	13
Current approaches to fate mapping and lineage tracing using image data	13
PRDM paralogs antagonistically balance Wnt/β-catenin activity during craniofacial chondrocyte differentiation	13
Microbial influences on gut development and gut-brain communication	13
Single-cell RNA sequencing reveals PDGFRα+ stromal cell subpopulations that promote proacinar cell differentiation in embryonic salivary gland organoids	13
Reactive oligodendrocyte progenitor cells (re-)myelinate the regenerating zebrafish spinal cord	13
let-7 miRNAs inhibit CHD7 expression and control auditory-sensory progenitor cell behavior in the developing inner ear	13
Formin 3 directs dendritic architecture via microtubule regulation and is required for somatosensory nociceptive behavior	13
Warm and cold temperatures have distinct germline stem cell lineage effects during Drosophila oogenesis	13
Natural killer cells act as an extrinsic barrier for in vivo reprogramming	13
Dynamic properties of mitochondria during human corticogenesis	13
E2F1 regulates testicular descent and controls spermatogenesis by influencing WNT4 signaling	13
Formal proof of the requirement of MESP1 and MESP2 in mesoderm specification and their transcriptional control via specific enhancers in mice	13
LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development	13
An atlas of seven zebrafish hox cluster mutants provides insights into sub/neofunctionalization of vertebrate Hox clusters	12
A developmental lineage-based gene co-expression network for mouse pancreatic β-cells reveals a role for Zfp800 in pancreas development	12
Fatty acid-binding proteins and fatty acid synthase influence glial reactivity and promote the formation of Müller glia-derived progenitor cells in the chick retina	12