Phytotherapy Research

Article	Citations
RETRACTION: Epigallocatechin‐3‐Gallate Enhances Differentiation of Acute Promyelocytic Leukemia Cells via Inhibition of PML‐RARα and HDAC1	279
Co‐administration of sub‐effective doses of the constituents of Crocus sativus L. crocins with those of the antipsychotics clozapine and risperidone counteract memory deficits caused by blockad	255
Phytochemicals targeting ferroptosis in cardiovascular diseases: Recent advances and therapeutic perspectives	157
Evaluation of the effect of Lepidium meyenii Walpers in infertile patients: A randomized, double‐blind, placebo‐controlled trial	137
Effects of different natural products in patients with non‐alcoholic fatty liver disease—A network meta‐analysis of randomized controlled trials	131
Safety assessment and adverse drug reaction reporting of tea tree oil (Melaleuca aetheroleum)	113
Effects of gypenoside L‐containingGynostemma pentaphyllumextract on fatigue and physical performance: A double‐blind, placebo‐controlled, randomized trial	112
Anti‐Warburg effect via generation of ROS and inhibition of PKM2/β‐catenin mediates apoptosis of lambertianic acid in prostate cancer cells	103
Pharmacovigilance of unlicensed cannabidiol in European countries	97
The influence of propolis plus Hyoscyamus niger L. against COVID‐19: A phase II, multicenter, placebo‐controlled, randomized trial	96
Morin attenuates osteoclast formation and function by suppressing the NF‐κB, MAPK and calcium signalling pathways	92
Preclinical studies of the antitumor effect of curcumin‐loaded polymeric nanocapsules: A systematic review and meta‐analysis	90
Schisandra B, a representative lignan from Schisandra chinensis, improves cisplatin‐induced toxicity: An in vitro study	86
Phytoncides could potentially inhibit the spike protein of SARS‐CoV‐2 variants	85
Saponin monomers: Potential candidates for the treatment of type 2 diabetes mellitus and its complications	84
Maltol mitigates cisplatin‐evoked cardiotoxicity via inhibiting the PI3K/Akt signaling pathway in rodents in vivo and in vitro	84
Curculigoside rescues hippocampal synaptic deficits elicited by PTSD through activating cAMP‐PKA signaling	82
Harnessing Essential Oils for Acetylcholinesterase Inhibition: A Literature Review	81
Curcumin as a therapeutic agent in cancer therapy: Focusing on its modulatory effects on circularRNAs	80
The effect of propolis supplementation on cardiovascular risk factors in women with rheumatoid arthritis: A double‐blind, placebo, controlled randomized clinical trial	78
Issue Information	72
Antiplatelet effect of ginkgo diterpene lactone meglumine injection in acute ischemic stroke: A randomized, double‐blind, placebo‐controlled clinical trial	71
The effects of spirulina intake on clinical and metabolic parameters in Alzheimer's disease: A randomized, double‐blind, controlled trial	68
Natural compounds as obesity pharmacotherapies	68
Astragaloside IV Alleviates Acute Hepatic Injury by Regulating Macrophage Polarization and Pyroptosis via Activation of the AMPK/SIRT1 Signaling Pathway	67

Xanthohumol Regulates Mitophagy in Osteosarcoma Cells via AMPK‐ULK1‐FUNDC1 Signaling Pathway	67
Licarin A, a neolignan isolated from Nectandra oppositifolia Nees & Mart. (Lauraceae), exhibited moderate preclinical efficacy against Schistosoma mansoni infection	66
Bryodulcosigenin attenuates bleomycin‐induced pulmonary fibrosis via inhibiting AMPK‐mediated mesenchymal epithelial transition and oxidative stress	64
Dietary plants for oral cancer prevention and therapy: A review of preclinical and clinical studies	61
Phase III randomized clinical trial of BV‐4051, an Ayurvedic polyherbal formulation in moderate SARS‐CoV‐2 infections and its impact on inflammatory biomarkers	61
Efficacy of frankincense‐based herbal product in urinary incontinence: A randomized, double‐blind, placebo‐ and active‐controlled clinical trial	59
Vegetable‐derived indole enhances the melanoma‐treating efficacy of chemotherapeutics	57
Ellagitannin Component Punicalin Ameliorates Cognitive Dysfunction, Oxidative Stress, and Neuroinflammation via the Inhibition of cGAS‐STING Signaling in the Brain of an Aging Mo	57
Polydatin as a therapeutic alternative for central nervous system disorders: A systematic review of animal studies	56
Ethanol extract of Pueraria lobata improve acute myocardial infarction in rats via regulating gut microbiota and bile acid metabolism	54
Polysaccharides (pectin, mucilage, and fructan inulin) and their fermented products: A critical analysis of their biochemical, gut interactions, and biological functions as antidiabetic agents	50
Cover Image	49
	49
Mechanisms and Potential of Antitumor Therapy With Natural Products Regulating Non‐Coding RNAs	48
	48
Bavachinin selectively modulates PPAR γ and maintains bone homeostasis in Type 2 Diabetes	47
Nootkatone alleviates rotenone‐induced Parkinson's disease symptoms through activation of the PI3K/Akt signaling pathway	47
Curcumin–cisplatin chemotherapy: A novel strategy in promoting chemotherapy efficacy and reducing side effects	47
The alleviative effect of flavonol‐type Nrf2 activator rhamnazin from Physalis alkekengi L. var. franchetii (Mast.) Makino on pulmonary disorders	47
Effects of artichoke leaf extract supplementation or artichoke juice consumption on lipid profile: A systematic review and dose–response meta‐analysis of randomized controlled trials	47
Asiatic acid inhibits angiogenesis and vascular permeability through the VEGF/VEGFR2 signaling pathway to inhibit the growth and metastasis of breast cancer in mice	46
Aromatic monophenols from cinnamon bark act as proteasome inhibitors by upregulating ER stress, suppressing FoxM1 expression, and inducing apoptosis in prostate cancer cells	45
Upregulation of key factors of viral entry of corona‐ and influenza viruses upon TLR3‐signaling in cells from the respiratory tract and clinical treatment options by 1,8‐Cineol	43
Substantial Effects of Carotenoids on Skin Health: A Mechanistic Perspective	43
Mitochondrial‐targeted curcumin inhibits T‐cell activation via Nrf2 and inhibits graft‐versus‐host‐disease in a mouse model	43
Effect of curcumin on C‐reactive protein as a biomarker of systemic inflammation: An updated meta‐analysis of randomized controlled trials	43
SH‐PRO extract alleviates benign prostatic hyperplasia via ROS‐mediated activation of PARP/caspase 3 and inhibition of FOXO3a/AR/PSA s	43
Urolithin A alleviates acute kidney injury induced by renal ischemia reperfusion through the p62‐Keap1‐Nrf2 signaling pathway	43
Exploring the therapeutic implications of natural compounds modulating apoptosis in vascular dementia	42
Cardiovascular benefits of Eruca sativa mill. Defatted seed meal extract: Potential role of hydrogen sulfide	42
Ouratein D, a Biflavanone From Ouratea spectabilis, Alleviates Betacoronavirus Infection by Mitigating Inflammation, Lung Damage and Viral Replication	42
Immunostimulant plant proteins: Potential candidates as vaccine adjuvants	42
Jatrorrhizine alleviates cytokine storm secondary lung injury via regulating CD39‐dominant purinergic braking and downstream NLRP3 inflammasome	42
Fangchinoline abrogates growth and survival of hepatocellular carcinoma by negative regulation of c‐met/HGF and its associated downstream signaling pathways	41
Morus alba L. water extract changes gut microbiota and fecal metabolome in mice induced by high‐fat and high‐sucrose diet plus low‐dose streptozotocin	40
Trilobatin promotes angiogenesis after cerebral ischemia–reperfusion injury via SIRT7/VEGFA signaling pathway in rats	40
A grape (Vitis vinifera L.) pomace water extract modulates inflammatory and immune response in SW‐480 cells and isolated mouse colon	39
Quercetin as a protective agent for liver diseases: A comprehensive descriptive review of the molecular mechanism	39
Hyperoside prevents doxorubicin‐induced cardiotoxicity by inhibiting NOXs/ROS/NLRP3 inflammasome signaling pathway	39
Brazilian red propolis exerts a cytotoxic action against prostate cancer cells and upregulates human monocyte functions	39
Therapeutic Potential of Chinese Herbal Medicine and Underlying Mechanism for the Treatment of Myocardial Infarction	39
Issue Information	38
The effects of Garcinia cambogia (hydroxycitric acid) on lipid profile: A systematic review and meta‐analysis of randomized controlled trials	38
Issue Information	38
Costunolide protects against alcohol‐induced liver injury by regulating gut microbiota, oxidative stress and attenuating inflammation in vivo and in vitro	38
Pterostilbene Exhibits Broad‐Spectrum Antiviral Activity by Targeting the Enterovirus Capsid, Inactivating Viral Particles, Blocking Viral Binding, and Protecting Mice From Lethal EV‐A	37
Formononetin Induces Ferroptosis in Activated Hepatic Stellate Cells to Attenuate Liver Fibrosis by Targeting NADPH Oxidase 4	37
Issue Information	37
	37
Formononetin attenuates cigarette smoke‐induced COPD in mice by suppressing inflammation, endoplasmic reticulum stress, and apoptosis in bronchial epithelial cells via AhR/C	36

Resistant starch from black rice, Oryza sativaL. var. ameliorates renal inflammation, fibrosis and injury in insulin resistant rats	36
Effect of sumac powder on clinical symptoms, hyperandrogenism, inflammation, blood glucose, lipid profiles in women with polycystic ovary syndrome: A double‐blind randomized clinical trial	36
Effects of resveratrol on female reproduction: A review	36
Jaridon 6, a new diterpene from Rabdosia rubescens (Hemsl.) Hara, can display anti‐gastric cancer resistance by inhibiting SIRT1 and inducing autophagy	35
Natural products targeting macroautophagy signaling in hepatocellular carcinoma therapy: Recent evidence and perspectives	35
Neuroinflammation inhibition and neuroprotective effects of purpurin, a potential anti‐AD compound, screened via network proximity and gene enrichment analyses	35
Anthocyanin oligomers stimulate browning in 3T3‐L1 white adipocytes via activation of the β3‐adrenergic receptor and ERK signaling pathway	35
Rosa Damascena mill for treating adults' anxiety, depression, and stress: A systematic review and dose–response meta‐analysis of randomized controlled trials	35
Therapeutic considerations of bioactive compounds in Alzheimer's disease and Parkinson's disease: Dissecting the molecular pathways	35
Curcumin supplementation as a complementary and alternative medicine for COVID‐19 patients	34
Effects of ginseng consumption on the biomarkers of oxidative stress: A systematic review and meta‐analysis	34
Is the mushroom Meripilus giganteus a potential cancer chemopreventive agent?	34
Effect of walnut consumption on markers of endothelial function in adults: A systematic review and meta‐analysis of randomized controlled trials	34
An exploratory double‐blind, randomized, placebo‐controlled study to assess the efficacy of CitruSlim on body composition and lipid parameters in obese individuals	34
Current clinical developments in curcumin‐based therapeutics for cancer and chronic diseases	34
Natural products in suppressing glioma progression: A focus on the role of microRNAs	34
Lotusine ameliorates propionic acid‐induced autism spectrum disorder‐like behavior in mice by activating D1 dopamine receptor in medial prefrontal cortex	34
Traditional medicinal plants in the treatment of gastrointestinal parasites in humans: A systematic review and meta‐analysis of clinical and experimental evidence	33
Astragaloside IV ameliorates radiation‐induced nerve cell damage by activating the BDNF/TrkB signaling pathway	33
Phytocompounds and COVID‐19: Two years of knowledge	32
Chemical constituents, biological activities and anti‐rheumatoid arthritic properties of four citrus essential oils	32
miRNA, phytometabolites and disease: Connecting the dots	32
Helichrysum stoechas (L.) Moench reduces body weight gain and modulates mood disorders via inhibition of silent information regulator 1 (SIRT1) by arzanol	32
The effects of lycopene supplementation on insulin‐like growth factor‐1 and insulin‐like growth factor binding proteins: A systematic review of randomized controlled trials	32
Ginkgo Flavone Aglycone Ameliorates Atherosclerosis via Inhibiting Endothelial Pyroptosis by Activating the Nrf2 Pathway	32
Trifolirhizin reduces osteoclast formation and prevents inflammatory osteolysis by inhibiting RANKL‐induced activation of NF‐κB and MAPK signaling pathways and ROS	32
Therapeutic effect of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. leaves on ischemic stroke via the microbiota–gut–brain axis	32
Gut microbiota, bile acids, and nature compounds	32
A randomized, double‐blind, placebo‐controlled study of Cistanche tubulosa and Ginkgo biloba extracts for the improvement of cognitive function in middle‐aged and elderly people	32
Exploiting new strategies in combating head and neck carcinoma: A comprehensive review on phytochemical approaches passing through PI3K/Akt/mTOR signaling pathway	32
Efficacy of Extracts of Oleogum Resin of Boswellia in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta‐Analysis	31
Efficacy of herbal treatments for functional dyspepsia: A systematic review and meta‐analysis of randomized clinical trials	31
Hypoglycemic Effect of Ginsenoside Compound K Mediated by N‐Acetylserotonin Derived From Gut Microbiota	31
Peiminine regulates bone‐fat balance by canonical Wnt/β‐catenin pathway in an ovariectomized rat model	31
Effects of Dietary Polyphenols on Vasculogenic Erectile Dysfunction: A Systematic Review of Pre‐Clinical Studies	31
Tetrandrine Alleviates Pulmonary Fibrosis by Modulating Lung Microbiota‐Derived Metabolism and Ameliorating Alveolar Epithelial Cell Senescence	31
Antitumor effect of luteolin proven by patient‐derived organoids of gastric cancer	31
Acetylshikonin Derived From Arnebia euchroma (Royle) Johnst Kills Multidrug‐Resistant Gram‐Positive Pathogens In Vitro and In Vivo	31
Columbianadin Ameliorates Myocardial Injury by Inhibiting Autophagy Through the PI3K/Akt/mTOR Signaling Pathway in AMI Mice and Hypoxic H9c2 Cells	30
Artemether Ameliorates Non‐Alcoholic Steatohepatitis by Restraining Cross‐Talk Between Lipotoxicity‐Induced Hepatic Hepatocytes and Macrophages	30
Curcumin and nano‐curcumin applications in psychiatric disorders	30
What is the influence of cinnamon supplementation on liver enzymes? A systematic review and meta‐analysis of randomized controlled trials	29
Withanolides: Promising candidates for cancer therapy	29
Cornuside, by regulating the AGEs‐RAGE‐IκBα‐ERK1/2 signaling pathway, ameliorates cognitive impairment associated with brain aging	29
The effect of saffron (Crocus sativus L.) on glycemia, lipid profile, and antioxidant status in patients with type‐2 diabetes mellitus: A randomized placebo‐controlled trial	29
	29
Erucin Alleviates Cardiac Hypertrophy by Improving Mitochondrial Function via Nrf2‐Sirt3 Pathway	29
Xanthotoxin (8‐methoxypsoralen): A review of its chemistry, pharmacology, pharmacokinetics, and toxicity	29
Issue Information	29
Perilla seed oil improves bone health by inhibiting bone resorption in healthy Japanese adults: A 12‐month, randomized, double‐blind, placebo‐controlled trial	28
Potato protease inhibitor II prevents obesity by inducing browning of white adipose tissue in mice via β3 adrenergic receptor signaling pathway	28
Isoliquiritigenin Exhibits Anti‐Inflammatory Responses in Acute Lung Injury by Covalently Binding to the Myeloid Differentiation Protein‐2 Domain	28
Effects of Sumac Supplementation on Lipid Profile: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials	28
Behavioral and Neuroprotective Properties of the Phytoestrogen 8‐Prenylnaringenin (8‐PN) in Ovariectomized Mice	28
The effects of flavonoids in experimental sepsis: A systematic review and meta‐analysis	27
Ursolic acid inhibits the activation of smoothened‐independent non‐canonical hedgehog pathway in colorectal cancer by suppressing AKT signaling cascade	27
Effects of adjuvant berberine therapy on acute ischemic stroke: A meta‐analysis	27
The efficacy of curcumin supplementation on serum total antioxidant capacity, malondialdehyde, and disease activity in women with rheumatoid arthritis: A randomized, double‐blind, placebo‐controlled c	27
Magnolol alleviates pulmonary fibrosis inchronic obstructive pulmonary disease by targeting transient receptor potential vanilloid 4‐ankyrin repeat domain	27
Salidroside improves blood–brain barrier integrity and cognitive function in hypobaric hypoxia mice by inhibiting microglia activation through GSK3β	27
Zeylenone synergizes with cisplatin in osteosarcoma by enhancing DNA damage, apoptosis, and necrosis via the Hsp90/AKT/GSK3β and Fanconi anaemia pathway	26
Germacrone alleviates breast cancer‐associated osteolysis by inhibiting osteoclastogenesis via inhibition of MAPK/NF‐κB signaling pathways	26
Protective effects of 4‐geranyloxy‐2,6‐dihydroxybenzophenonel on DSS‐induced ulcerative colitis in mice via regulation of cAMP/PKA/CREB and NF‐κB	26
Taxifolin‐mediated Nrf2 activation ameliorates oxidative stress and apoptosis for the treatment of glucocorticoid‐induced osteonecrosis of the femoral head	26
Total glucosides of white paeony capsule alleviate articular cartilage degeneration and aberrant subchondral bone remodeling in knee osteoarthritis	26
Combination of Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos improves cardiac function of diabetic cardiomyopathy mice by regulating the unfolded protein response signaling pathway	26
The potential health benefits of aloin from genus Aloe	25
Phytosomes as a New Frontier and Emerging Nanotechnology Platform for Phytopharmaceuticals: Therapeutic and Clinical Applications	25
Systematic Review and Network Meta‐Analysis of the Effects of Plant Extracts on Cognitive Function and Quality of Life in Stroke Patients	25
Tanshinone IIA improves contextual fear‐ and anxiety‐like behaviors in mice via the CREB/BDNF/TrkB signaling pathway	25
Total flavonoids of Rhizoma drynariae promote angiogenesis and osteogenesis in bone defects	25
Unlocking the Therapeutic Potential of Autophagy Modulation by Natural Products in Tackling Non‐Alcoholic Fatty Liver Disease	25
Curcumin suppressed the proliferation and apoptosis of HPV‐positive cervical cancer cells by directly targeting the E6 protein	25
Sinigrin Selectively Mitigates the Acute‐Cardiac Inflammatory Response Through an AMPK‐Dependent Mechanism	25
Increasing brain glucose uptake by Gypenoside LXXV ameliorates cognitive deficits in a mouse model of diabetic Alzheimer's disease	25
Phytochemicals mediated modulation of microRNAs and long non‐coding RNAs in cancer prevention and therapy	25
Wogonin and its analogs for the prevention and treatment of cancer: A systematic review	25
Issue Information	24
	24
The 6‐month effect of whole soy and purified isoflavones daidzein on thyroid function—A double‐blind, randomized, placebo controlled trial among Chinese equol‐producing po	24

Poncirus trifoliata Extract and Its Active Coumarins Alleviate Dexamethasone‐Induced Skeletal Muscle Atrophy by Regulating Protein Synthesis, Mitochondrial Biogenesis, and Gut Microb	24
Maslinic Acid Ameliorates DSS‐Induced Experimental Colitis by Suppressing Th Cell‐Mediated Inflammation via AICD Induction	24
A review on phytoestrogens: Current status and future direction	24
Integrated Microbiome and Metabolomic to Explore the Mechanism of Coptisine in Alleviating Ulcerative Colitis	24
A Marine‐Derived Small Molecule Inhibits Prostate Cancer Growth by Promoting Endoplasmic Reticulum Stress Induced Apoptosis and Autophagy	24
Medicinal herbs consumption in relation to cardiometabolic indices and coronary artery stenosis in participants undergoing coronary angiography: A cross‐sectional study	23
Hepatoprotective effect of dietary pterostilbene against high‐fat‐diet‐induced lipid accumulation exacerbated by chronic jet lag via SIRT1 and SIRT3 activation	23
Paeoniflorin‐6′‐O‐benzene sulfonate protected the intestinal epithelial barrier by restoring the inhibitory effect of GRK2 and β‐arrestin 2 on ERK1/2‐NF‐κB	23
The therapeutic effects of berberine against different diseases: A review on the involvement of the endoplasmic reticulum stress	23
Natural Compounds Exert Anti‐Obesity Effects by Regulating Cytokines	23
Licochalcone A inhibits MAS‐related GPR family member X2‐induced pseudo‐allergic reaction by suppressing nuclear migration of nuclear factor‐κB	23
Antcin A, a phytosterol regulates SARS‐CoV‐2 spike protein‐mediated metabolic alteration in THP‐1 cells explored by the 1H‐NMR‐based metabolomics approach	23
Effects of licorice root supplementation on liver enzymes, hepatic steatosis, metabolic and oxidative stress parameters in women with nonalcoholic fatty liver disease: A randomized double‐blind clinic	23
Pharmacodynamics of Aloe vera and acemannan in therapeutic applications for skin, digestion, and immunomodulation	23
The role of natural products as PCSK9 modulators: A review	23
Effects of sea buckthorn (Hippophae rhamnoides L.) on factors related to metabolic syndrome: A systematic review and meta‐analysis of randomized controlled trial	23
Beneficial effects of Ginkgo biloba leaf extract on inflammatory markers: A systematic review and meta‐analysis of the clinical trials	23
Corosolic acid ameliorates non‐alcoholic steatohepatitis induced by high‐fat diet and carbon tetrachloride by regulating TGF‐β1/Smad2, NF‐κB, and AMPK signaling pathwa	22
Effectiveness of Curcuma longa extract versus placebo for the treatment of knee osteoarthritis: A systematic review and meta‐analysis of randomized controlled trials	22
Ameliorative effect ofLuffa cylindricafruits onCaenorhabditis elegansand cellular models of Alzheimer's disease‐related pathology via autophagy induction	22
Pomegranate effects on the health aspects of women during peri‐ and postmenopause: A systematic review and meta‐analysis	22
Naringin protects against inflammation and apoptosis induced by intestinal ischemia–reperfusion injury through deactivation of cGAS‐STING signaling pathway	22
Honokiol inhibits epithelial–mesenchymal transition and hepatic fibrosis via activation of Ecadherin/GSK3β/JNK and inhibition of AKT/ERK/p38/β‐catenin/	22
Moringa oleiferaLam. as a potential plant for alleviation of the metabolic syndrome—A narrative review based on in vivo and clinical studies	22
Plant‐derived virulence arresting drugs as novel antimicrobial agents: Discovery, perspective, and challenges in clinical use	22
Cancer metabolism control by natural products: Pyruvate kinase M2 targeting therapeutics	22
Thymol inTrachyspermum ammiseed extract exhibits neuroprotection, learning, and memory enhancement in scopolamine‐induced Alzheimer's disease mouse model	22
Trilobolide‐6‐O‐isobutyrate suppresses hepatocellular carcinoma tumorigenesis through inhibition of IL‐6/STAT3 signaling pathway	22
The therapeutic potential of typical plant‐derived compounds for the management of metabolic disorders	22
Pretreatment with Notoginsenoside R1 attenuates high‐altitude hypoxia‐induced cardiac injury via activation of the ERK1/2‐P90RSK‐Bad signaling pathway in rats	22
Molecular dynamics simulation and in vitro evaluation of herb–drug interactions involving dietary polyphenols and CDK inhibitors in breast cancer chemotherapy	22
Resveratrol and endoplasmic reticulum stress: A review of the potential protective mechanisms of the polyphenol	22
Potential use of curcumin against methicillin‐resistant Staphylococcus infection	22
Anticancer and chemopreventive potential of Morinda citrifolia L. bioactive compounds: A comprehensive update	22
Pomegranate polyphenol punicalagin improves learning memory deficits, redox homeostasis, and neuroinflammation in aging mice	22
Potential mechanism of oral baicalin treating psoriasis via suppressing Wnt signaling pathway and inhibiting Th17/IL‐17 axis by activating PPARγ	22
Cannabidiol tempers alcohol intake and neuroendocrine and behavioural correlates in alcohol binge drinking  adolescent rats. Focus on calcitonin gene‐related peptide's brain levels	22
Tussilagone ameliorates high‐fat diet‐induced hepatic steatosis by enhancing energy metabolism and antioxidant activity	21
A comprehensive review of antitumor properties of Angelica species and their antitumor‐responsible constituents and the underlying molecular mechanisms involved in tumor inhibition	21
Issue Information	21
	21
Advances in Research on Marine Natural Products for Modulating the Inflammatory Microenvironment	21
Yerba mate (Ilex paraguariensis A. St.‐Hil.) for new therapeutic and nutraceutical interventions: A review of patents issued in the last 20 years (2000–2020)	21
Gastrodia elata Blume water extract modulates neurotransmitters and alters the gut microbiota in a mild social defeat stress‐induced depression mouse model	21
Issue Information	21
	21
Quercetin as a cancer chemopreventive or chemotherapeutic agent: Where we stand	21
Therapeutic effect of curcumin in gastrointestinal cancers: A comprehensive review	21
Curdione inhibits ferroptosis in isoprenaline‐induced myocardial infarction via regulating Keap1/Trx1/GPX4 signaling pathway	21
Curcumin: A Potential Detoxifier Against Chemical and Natural Toxicants	21
Identification of Cannabidiolic and Cannabigerolic Acids as MTDL AChE, BuChE, and BACE‐1 Inhibitors Against Alzheimer's Disease by In Silico, In Vitro, and In Vivo Stu	21
Contribution of traditional Chinese medicine combined with conventional western medicine treatment for the novel coronavirus disease (COVID‐19), current evidence with systematic review and	21
The pharmacological effects of Berberine and its therapeutic potential in different diseases: Role of the phosphatidylinositol 3‐kinase/AKT signaling pathway	21
Icariin, a phytoestrogen, exerts rapid estrogenic actions through crosstalk of estrogen receptors in osteoblasts	20
Salvianolic acid B alleviates autoimmunity in Treg‐deficient mice via inhibiting IL2‐STAT5 signaling	20
Role of herbal medicine for prevention and treatment of migraine	20
A critical review on clinical evidence of the efficacy of lavender in sleep disorders	20
Comparing the activity of propolis‐loaded nanoparticles or hydroethanolic extract on cytokine production by peripheral blood mononuclear cells	20
Eleutheroside B‐loaded poly (lactic‐co‐glycolic acid) nanoparticles protect against renal fibrosis via Smad3‐dependent mechanism	20
Effect of rosemary leaf powder with weight loss diet on lipid profile, glycemic status, and liver enzymes in patients with nonalcoholic fatty liver disease: A randomized, double‐blind clinical trial	20
Targeting autophagy and neuroinflammation pathways with plant‐derived natural compounds as potential antidepressant agents	20
The effects of Capsicum annuum supplementation on lipid profiles in adults with metabolic syndrome and related disorders: A systematic review and meta‐analysis of randomized controlled trials	20
Current therapeutic targets and multifaceted physiological impacts of caffeine	20
Alpinetin alleviates osteoporosis by promoting osteogenic differentiation in BMSCs by triggering autophagy via PKA/mTOR/ULK1 signaling	20
Myricetin reverses epithelial–endothelial transition and inhibits vasculogenic mimicry and angiogenesis of hepatocellular carcinoma by directly targeting PAR1	20
Kaempferol's potential effects againstSARS‐CoV‐2 andCOVID‐19‐associated cancer progression and chemo‐resistance	19
Green tea extract ameliorates macrophage‐driven emphysematous lesions in chronic obstructive pulmonary disease induced by cigarette smoke condensate	19
Triptolide promotes the apoptosis and attenuates the inflammation of fibroblast‐like synoviocytes in rheumatoid arthritis by down‐regulating lncRNA ENST00000619282	19
Ginger polysaccharide promotes myeloid‐derived suppressor cell apoptosis by regulating lipid metabolism	19
Curcumin and its anti‐colorectal cancer potential: From mechanisms of action to autophagy	19
Quercetin and its derivates as antiviral potentials: A comprehensive review	19
Proteomic and metabolomic approaches elucidate the molecular mechanism of emodin against neuropathic pain through modulating the gamma‐aminobutyric acid (GABA)‐ergic pathway and PI3K	19
Aqueous extract ofCeratonia siliquaL. leaves elicits antioxidant, anti‐inflammatory, andAChEinhibiting effects in amyloid‐β42‐induced cognitive deficit mice: Role ofα7‐nAChR	19
Agrimoniin is a dual inhibitor of AKT and ERK pathways that inhibit pancreatic cancer cell proliferation	19
A Comprehensive Review of Biologically Active Natural Products on Human Papillomavirus (HPV) at a Glance	19
Crosstalk between traditional Chinese medicine‐derived polysaccharides and the gut microbiota: A new perspective to understand traditional Chinese medicine	19
Cryptotanshinone alleviates radiation‐induced lung fibrosis via modulation of gut microbiota and bile acid metabolism	19
Tenuifolin ameliorates chronic restraint stress‐induced cognitive impairment in C57BL/6J mice	19
Quercetin prevented diabetic nephropathy by inhibiting renal tubular epithelial cell apoptosis via the PI3K/AKT pathway	19
Fisetin attenuates doxorubicin‐induced cardiotoxicity by inhibiting the insulin‐like growth factor II receptor apoptotic pathway through estrogen receptor‐α/‐β activation	19
Asiaticoside ameliorates DSS‐induced colitis in mice by inhibiting inflammatory response, protecting intestinal barrier and regulating intestinal microecology	19
Hesperidin reduces systolic blood pressure in diabetic patients and has no effect on blood pressure in healthy individuals: A systematic review and meta‐analysis	19
In vitro characterization of iridoid and phenylethanoid glycosides from Cistanche phelypaea for nutraceutical and pharmacological applications	19
An extensive review on phytochemistry and pharmacological activities of Indian medicinal plantCelastrus paniculatusWilld	19
Anti‐inflammatory effect of dictamnine on allergic rhinitis via suppression of the LYN kinase‐mediated molecular signaling pathway during mast cell activation	19
Astaxanthin supplementation impact on insulin resistance, lipid profile, blood pressure, and oxidative stress in polycystic ovary syndrome patients: A triple‐blind randomized clinical trial	18
Juglone promotes antitumor activity against prostate cancer via suppressing glycolysis and oxidative phosphorylation	18
Propolis as an adjunctive therapy for treatment of uncomplicated cystitis in women: A randomized double‐blind placebo‐controlled trial	18
Tanshinone IIA alleviates acute ethanol‐induced myocardial apoptosis mainly through inhibiting the expression of PDCD4 and activating the PI3K/Akt pathway	18
The interplay between fibroblast‐like synovial and vascular endothelial cells leads to angiogenesis via the sphingosine‐1‐phosphate‐induced RhoA‐F‐Actin and Ras‐Erk1/2 pathways a	18
Tetrandrine promotes the survival of the random skin flap via the PI3K/AKT signaling pathway	18
Phyto‐therapeutic potential of Withania somnifera: Molecular mechanism and health implications	18
Suspected adverse reactions to medications and food supplements containing Serenoa repens: A worldwide analysis of pharmacovigilance and phytovigilance spontaneous reports	18
The effect of saffron supplementation on glycemic parameters: An overview of systematic reviews	18
Insights into the anti‐Candida albicans properties of natural phytochemicals: An in vitro and in vivo investigation	18