Biofactors

Article	Citations
Issue Information	85
	69
Formation of Plant Derived Bioactive Peptides During Simulated Gastro‐Intestinal Digestion: A Systematic Review	68
Investigating rutin as a potential transforming growth factor‐β type I receptor antagonist for the inhibition of bleomycin‐induced lung fibrosis	63
Diverse Inhibitors of De Novo Purine Synthesis Promote AICAR ‐Induced AMPK Activation and Glucose	59
Attenuation of p38 MAPK / NF ‐ κB /	56
Hydroethanolic Soy Extract Rich in Isoflavones Protects Dystrophic Mutant Mice From Oxidative Stress and Inflammation via the ROS /	51
Delving Into the Multifaceted Role of Exosomal Cargo in Kidney Diseases: Mechanistic Pathways, Diagnostic Potential, and Therapeutic Applications	50
Long‐Term Intake of Oleic Acid‐Rich Palm Oil Induces Obesity Without Impairing Hypothalamic Insulin Sensitivity and Redox Activity in Male Wistar Rats	46
Lactate dehydrogenase A is implicated in the pathogenesis of B‐cell lymphoma through regulation of the FER signaling pathway	45
Issue Information	43
Long non‐coding RNA LINC01224 plays an oncogenic role in endometrial cancer via miR ‐4673/	40
The Role of STAT3 in Cancer: From Metabolic Regulation to Therapeutic Targeting	36
Retraction	36
Issue Information ‐ Cover	35
Endogenously produced hyaluronan contributes to the regulation of peritoneal adhesion development	34
The endocannabinoidome in human placenta: Possible contribution to the pathogenesis of preeclampsia	34
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR‐7/m‐TOR/SREBP1 pathway on prostate cancer	32
Correction to “Zerumbone, a ginger sesquiterpene, inhibits migration, invasion, and metastatic behavior of human malignant glioblastoma multiforme in vitro”	32
Is there an interplay between the SARS‐CoV‐2 spike protein and Platelet‐Activating factor?	31
Berberine chloride loaded nano‐ PEGylated liposomes attenuates imidacloprid‐induced neurotoxicity by inhibiting NLRP3	30
Three months of combination therapy with nano‐curcumin reduces the inflammation and lipoprotein (a) in type 2 diabetic patients with mild to moderate coronary artery disease: Evidence of a randomized,	29
Adipose tissue‐derived mesenchymal stem cells ameliorate cognitive impairment in Alzheimer's disease rat model: Emerging role ofSIRT1	28
Rosa gallica and its active compound, cyanidin‐3,5‐O‐diglucoside, improve skin hydration via the GLK signaling pathway	28
Knockdown of integrin β1 inhibits proliferation and promotes apoptosis in bladder cancer cells	28

N‐methyl‐d‐aspartate receptors: Structure, function, and role in organophosphorus compound poisoning	27
The neuropeptide substance P/neurokinin‐1 receptor system and diabetes: From mechanism to therapy	26
The possible role of the nucleoside adenosine in countering skin aging: A review	26
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Issue Information ‐ Cover	24
High glucose leads to redistribution of the proteasomal system	23
Deciphering the role of Zn2+‐binding histidines from TIA‐1 on the assembly and dynamics of stress granules	21
Dietary limonene promotes gastrointestinal barrier function via upregulating tight/adherens junction proteins through cannabinoid receptor type‐1 antagonistic mechanism and alters cellular metabolism	21
Crocetin regulates Th1/Th2 and Th17/Treg balances, nitric oxide production, and nuclear localization of NF‐κB in Th2‐provoked and norm	21
Retraction	21
A novel peptide derived from Haematococcus pluvialis residue balanced lipid metabolism through NHR‐49/PPARα and AAK‐2/AMPK pathways in Caenorhabdi	21
Control of Mycobacterium tuberculosis infection in the elderly: Is there a role for epigenetic reprogramming reversal?	20
Melatonin protects Kir2.1 function in an oxidative stress‐related model of aging neuroglia	20
Deletion of NRF2 disturbs composition, morphology, and differentiation of the murine tail epidermis in chronological aging	20
Protein concentrations and activities of fatty acid desaturase and elongase enzymes in liver, brain, testicle, and kidney from mice: Substrate dependency	20
Bitter yet beneficial: The dual role of dietary alkaloids in managing diabetes and enhancing cognitive function	19
The in vitro anti‐cancer synergy of neurokinin‐1 receptor antagonist, aprepitant, and 5‐aminolevulinic acid in glioblastoma	19
Issue Information	18
Issue Information ‐ Cover	18
Agmatine suppresses glycolysis via the PI3K /Akt/ mTOR / HIF	18
Issue Information	18
Modulatory Effect of Natural Antioxidants on Tissue Transglutaminase Levels in Olfactory Ensheathing Cells Exposed to Amyloid‐β: Integrated Biochemical and Computational Analysis	18
Issue Information ‐ Cover	17
Corrigendum to “Fucosterol Promotes Browning in Mouse 3T3‐L1 AdipocytesThrough HO‐1/Nrf2 and AMPK Pathways”	17
Deubiquitinase PSMD14 promotes tumorigenicity of glioblastoma by deubiquitinating and stabilizing β‐catenin	17
Oleuropein Aglycone Modulates Oxidative Stress and Autophagy‐Related Pathways in Human Skeletal Muscle Cells	16
Proteomic profiling of intestinal epithelial‐like cell‐derived exosomes regulated by epigallocatechin gallate	16
Issue Information	16
Piperine: an emerging biofactor with anticancer efficacy and therapeutic potential	16
Gut microbiota contribution to selenium deficiency‐induced gut–liver inflammation	16
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A new strategy for screening novel functional genes involved in reduction of lipid droplet accumulation	16
Retraction	15
SP1/CTR1‐mediated oxidative stress‐induced cuproptosis in intervertebral disc degeneration	15
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Effects of calciprotein particles on EMT induction in an in vitro 3D‐cultured proximal tubule epithelial cell model of CKD	15
Issue Information	15
Protective effect of luteolin against chemical and natural toxicants by targeting NF‐κB pathway	15
Non‐beneficial effects of resveratrol on renal epithelial cell cultures: Implications in cell differentiation	14
Nuclear receptor 4A1 (NR4A1) upregulated by n ‐butylidenephthalide via the mitogen‐activated protein kinase (	14
Harnessing tumor‐derived exosomes: A promising approach for the expansion of clinical diagnosis, prognosis, and therapeutic outcome of prostate cancer	14
Navigating the immune landscape with plasma cells: A pan‐cancer signature for precision immunotherapy	14
Correction to “Inhibition of succinate dehydrogenase sensitizes cyclin E‐driven ovarian cancer to CDK inhibition”	14
Insights into an indolicidin‐derived low‐toxic anti‐microbial peptide's efficacy against bacterial cells while preserving eukaryotic cell viability	14
Vitamin D modulates the content of inflammatory microRNAs in extracellular vesicles from human adipocyte cells in inflammatory context	14
Combinatorial effect of Apigenin‐resveratrol on white adipocyte plasticity and trans‐differentiation for activating lipid metabolism	13
Echinacoside promotes collagen synthesis and survival via activation of IGF ‐1 signaling to alleviate UVB	13
Erratum to “Revisiting the therapeutic potential of tocotrienol”	13
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Retraction	13

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Leveraging supramolecular systems in biomedical breakthroughs	12
UPS and Kinases—Gatekeepers of the G1/S Transition	12
Multi‐Targeted Anti‐Diabetic Effects of Trifuhalol A From Edible Seaweed via Glycation Inhibition, Glucose Uptake Enhancement and Pancreatic Islet Protection	12
Clock system disruption in male Fischer 344 rats fed cafeteria diet and administered sweet treats at different times: The zeitgeber role of grape seed fl	12
miR‐222 exerts negative regulation on insulin signaling pathway in 3T3‐L1 adipocytes	12
Extracellular vesicles (EVs): A promising therapeutic tool in the heart tissue regeneration	12
Crocus sativus tepals extract suppresses subcutaneous adipose tissue hypertrophy and improves systemic insulin sensitivity in mice on high‐fat diet	12
Identification and validation of the TRHDE‐AS1 / hsa‐miR ‐449a/ ADAMTS5	11
Therapeutic potential of phytochemicals for cystic fibrosis	11
The role of LncRNA‐regulated autophagy in AKI	11
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BACE1 : Biological Functions and Involvement in the Pathophysiology of Alzheimer's Disease and Other Neurological Disorders	11
Piperlongumine Triggers Reactive Oxygen Species Driven Mitochondrial Dysfunction Leading to Apoptosis in Human Colon Cancer Cells	11
Correction to “Knockdown of Integrin β1 Inhibits Proliferation and Promotes Apoptosis in Bladder Cancer Cells”	11
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The Function and Supramolecular Assembly of the Mitochondrial Respiratory Complexes Underlie Hypertension‐Related Stroke Susceptibility in a Model of Complex Human Disease	10
Correction to EVs Biodistribution and Antifibrotic Impact in Aged Lung Fibrosis Model	10
Mechanisms of cancer cell death induction by triptolide	10
Scent Goes Digital: The Role of Insect Odorant Binding Proteins in Modern Technology	10
Issue Information	10
Garcinia gummi‐gutta: Phytochemicals and pharmacological applications	10
Bromelain Alleviates 3‐Nitropropionic Acid‐Induced Huntington's Disease‐Like Symptoms in Rats Through the Interplay of SIRT1 /	10
Correction to “Untargeted metabolomics reveals biomarkers for the diagnosis of coronary artery plaques as observed by coronary cardiac computed tomography”	9
The Nuclear Face of PTEN : Implications in Cancer Prognosis and Targeted Therapy	9
Issue Information ‐ Cover	9
Fucosterol Promotes Browning in Mouse 3T3 ‐ L1 Adipocytes Through HO	9
Issue Information ‐ Cover	9
Gut Microbial Metabolite Crosstalk in Crohn's Disease: Network Pharmacology Unveils Dual‐Axis Pathogenesis and Therapeutic Targets	9
Issue Information ‐ Cover	9
Andrographolide Promotes Ferroptosis in Pancreatic Cancer via Targeting and Activating HSP90 / GPX4	9
Bioaccessible Sulforaphane Drives Macrophage Migration and Differentiation by Reprogramming the Interleukin Profile in Intestinal Inflammation	9
Molecular Extremes of Ovarian Response: Divergent PI3K / AKT / mTOR	8
Nrf2 driven macrophage responses in diverse pathophysiological contexts: Disparate pieces from a shared molecular puzzle	8
Issue Information ‐ Cover	8
Blueberry intervention mitigates detrimental microbial metabolite trimethylamine N‐oxide by modulating gut microbes	8
Issue Information ‐ Cover	8
ISG15 Mediates Oxidative Stress Modulation in T2DM Patients by Directly Targeting PIK3R2	8
Torpor‐responsive microRNAs in the heart of the Monito del monte, Dromiciops gliroides	8
Carboxylative efficacy of trans and cisMK7 and comparison with other vitamin K isomers	8
Resolvin D1: A key endogenous inhibitor of neuroinflammation	8
Fermented Cabbage Brine as a Functional Dietary Modulator of Neuroinflammation, Oxidative Stress, and Anxiety‐Like Behavior in Lipopolysaccharide‐Challenged Mice	8
DISC1 inhibits GSK3β activity to prevent tau hyperphosphorylation under diabetic encephalopathy	8
Altered rich‐club organization of brain functional network in autism spectrum disorder	8
Crosstalk among miR ‐29, α‐SMA , and TGFβ1 /β3	8
Retraction	7
Machine learning‐derived peripheral blood transcriptomic biomarkers for early lung cancer diagnosis: Unveiling tumor‐immune interaction mechanisms	7
Isolation and characterization of N‐(2‐Hydroxyethyl)hexadecanamide from Colletotrichum gloeosporioides with apoptosis‐inducing potential in breast cancer cells	7
Jagged1‐Fluc: A Luminescent Recombinant Protein as a Sensitive Tool for High‐Throughput Screening of Colorectal Cancer	7
Cannabinoids in neuroinflammatory disorders: Focusing on multiple sclerosis, Parkinsons, and Alzheimers diseases	7
Trace elements as potential modulators of puberty‐induced amelioration of oxidative stress and inflammation in childhood obesity	7
Retraction	7
Issue Information	7
The interlacing anticancer effect of pharmacologic ascorbate, chloroquine, and resveratrol	7
Platelet‐activating factor and microvesicle particles as potential mediators for the toxicity associated with intoxicated thermal burn injury	7
Integrative multi‐omic and machine learning approach for prognostic stratification and therapeutic targeting in lung squamous cell carcinoma	6
Reduced iron and cobalt levels in response to curcumin supplementation are not responsible for the prolonged larval development and do not affect the oxidative stress tolerance and polyamine status of	6
Deep Learning‐Driven Enzyme Engineering in Pichia pastoris : A Sustainable Platform for High‐Yield Nootkatone Biosynthesis	6
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Issue Information	6
O ‐ GlcNAcylation regulates osteoblast differentiation through the morphological changes in mitochondria, cytoskeleton, an	6
The in vitro and in vivo skin‐whitening activity of Ectoine through enhanced autophagy in melanocytes and keratinocytes and zebrafish model	6
Effect of High Hydrostatic Pressure ( HHP ) on the Enzymatic Hydrolysis of Fish Gelatin	6
Oral Administration of Crocus sativus Tepals Extract Restores High‐Fat Diet‐Induced Gut Dysbiosis and Modulates Intestinal Inflammation and Hepatic Lipid	6
The role of PAF in immunopathology: From immediate hypersensitivity reactions to fungal defense	6
Platelet‐activating factor as an endogenous cofactor of food anaphylaxis	6
Oxidized phospholipids and lipoprotein‐associated phospholipase A2 (Lp‐PLA2) in atherosclerotic cardiovascular disease: An update	6
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Lobaric acid suppresses the stemness potential of colorectal cancer cells through mTOR / AKT	6
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The role of NRF2 transcription factor in inflammatory skin diseases	6
Correction to “Bioactive Peptides in Preterm Human Milk: Impact of Maternal Characteristics and Their Association to Neonatal Outcomes”	6
Resolvins protect against diabetes‐induced colonic oxidative stress, barrier dysfunction, and associated diarrhea via the HO‐1 pathway	6
Ameliorating diabetes‐induced testicular dysfunction by modulating PKC/Nrf2/Bcl‐2 signaling: Protective role of sulbutiamine	6
Therapeutic Potential of Resveratrol in Cancer and Neurodegenerative Disorders: A Current Review	6
Docosahexaenoic acid may inhibit immune evasion of colorectal cancer cells through targeting immune checkpoint and immunomodulator genes and their controlling microRNAs	6
The influence of apigenin on cellular responses to radiation: From protection to sensitization	6
Planning the new phase of BioFactors: An IUBMB journal	6
High‐fat diet induced obesity promotes inflammation, oxidative stress, and hepatotoxicity in female FVB/N mice	6
Neuroprotective Effects of SELFormer ‐Selected β‐Citronellol and β‐Caryophyllene in Vagotomized Ischemic Stroke Model Through Direct Brain Protection	6

Unlocking the Antiadipogenic Potential of Carotenoids From Galdieria phlegrea	6
Retraction	5
The role of P450 enzymes in malaria and other vector‐borne infectious diseases	5
Melatonin mediated activation of MAP kinase pathway may reduce DNA damage stress in plants: A review	5
Morin overcomes doxorubicin resistance in human breast cancer by inducing DNA damage and modulating the LKB1	5
Topical application of gemcitabine generates microvesicle particles in human and murine skin	5
Anticancer effect of minor phytocannabinoids in preclinical models of multiple myeloma	5
Pax‐8: Molecular biology, pathophysiology, and potential pathogenesis	5
Sacubitril/valsartan promotes white adipose tissue browning in rats with metabolic syndrome through activation of mTORC1	5
HSP27 Promotes Cutaneous Squamous Cell Carcinoma Progression by Inhibiting Ferroptosis	5
The Potential Role of Matrix Metalloproteinase in Polycystic Ovary Syndrome: Implications for Extracellular Matrix Remodeling	5
Natural Product Daidzin Inhibits Glioma Development via Suppressing the LRP5‐Mediated GSK‐3β/c‐Myc Signaling Pathway	5
Growth differentiation factor‐15 is independently associated with metabolic syndrome and hyperglycemia in non‐elderly subjects	5
Investigating the impact of Ras‐related protein RAB7A on colon adenocarcinoma behavior and its clinical significance	5
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Profiling of RUVBL2 ‐Induced Transcriptome Alterations Highlights a Critical Role for Chromatin Remodeling in Ovarian Cancer	5
Bioactive dietary components—Anti‐obesity effects related to energy metabolism and inflammation	5
PAF‐induced inflammatory and immuno‐allergic ophthalmic diseases and their mitigation with PAF receptor antagonists: Cell and nuclear effects	5
Preface	4
Possible mitigating effect of adropin on lung injury in diabetic rats: Targeting the role of Rho A/Rho‐associated kinase pathway	4
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Protein kinase CK2: An emerging regulator of cellular metabolism	4
OSBPL10‐CNBP axis mediates hypoxia‐induced pancreatic cancer development	4
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Inhibition of glioblastoma proliferation, invasion, and migration by Urolithin B through inducing G0/G1 arrest and targeting MMP‐2/‐9 expression and activity	4
Dietary carbohydrates: Pathogenesis and potential therapeutic targets to obesity‐associated metabolic syndrome	4
Platelet Activating Factor (PAF): A Mediator of Inflammation	4
CEP55 Drives Pancreatic Cancer Progression by Suppressing Ferroptosis	4
Hexokinase 2‐Driven Cardioprotection in Ischemia, Hypertrophy, and Regeneration: From Underlying Mechanisms to Clinical Translation	4
The Therapeutic Potential of Flavonols in Alzheimer's Disease: Inhibiting Amyloid‐β, Oxidative Stress, and Neuroinflammation	4
Untargeted metabolomics reveals biomarkers for the diagnosis of coronary artery plaques as observed by coronary cardiac computed tomography	4
Taurine rescues pancreatic β‐cell stress by stimulating α‐cell transdifferentiation	4
Suffruticosol A elevates osteoblast differentiation targeting BMP2‐Smad/1/5/8‐RUNX2 in pre‐osteoblasts	4
Issue Information	4
Investigate the metabolic changes in intestinal diseases by employing a 1 H	4
Translational aspect in peptide drug discovery and development: An emerging therapeutic candidate	4
Molecular modeling and in vitro studies of gedunin a potent alpha‐amylase inhibitor and alpha‐glucosidase inhibitor	4
Fingernail Mineral Profiling as a Non‐Invasive Tool to Assess Dietary and Lifestyle Factors: Results From the Cross‐Sectional Fulda NutriNAIL Study	4
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Integration of miRNA in exosomes and single‐cell RNA‐seq profiles in endemic osteoarthritis, Kashin–Beck disease	4
The flavonoid quercetin decreases ACE2 and TMPRSS2 expression but not SAR	4
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Impact of Cellular Senescence on LCN2 Expression in Salivary Gland Epithelial Cells and Oral Keratinocytes	4
Antioxidant, anti‐inflammatory and epigenetic potential of curcumin in Alzheimer's disease	3
Issue Information	3
Artificial Intelligence for Detection of Parkinson's Disease From Speech Signals—A Comprehensive Review	3
Pathophysiology of Endoplasmic Reticulum Stress and the Potential Role of Dexmedetomidine as a Modulator	3
Mitochondria‐Targeting SIRT3 Activator Effectively Controls Bleomycin‐Induced Pulmonary Fibrosis	3
Tau, tau kinases, and tauopathies: An updated overview	3
Eupatilin Ameliorates Sepsis‐Induced Myocardial Injury by Targeting the KAT5 ‐ H3K27la Epigenetic	3
Preface	3
Salvia hispanica L. (chia) seed improves redox state and reverts extracellular matrix collagen deposition in skeletal muscle of sucrose‐rich diet‐fed rats	3
A Comprehensive Insight Into the Roles of Exosomal circRNAs in Metabolic Syndrome	3
Fabp5 Is the Key Regulator Mediating γ‐ CEHC Differentiation in Osteoblasts and Osteoclasts	3
Blockade of PD‐1 and CTLA‐4: A potent immunotherapeutic approach for hepatocellular carcinoma	3
Deciphering potential molecular mechanisms in clear cell renal cell carcinoma based on the ubiquitin‐conjugating enzyme E2 related genes: Identifying	3
Is There an Ace Up One's Sleeve in the Preanalytical Phase of the Circulating Tumor DNA Analysis?	3
Vasoactive intestinal peptide exerts an osteoinductive effect in human mesenchymal stem cells	3
Treatment of the metabolic syndrome by siRNA targeting apolipoprotein CIII	3
Catechol‐induced covalent modifications modulate the aggregation tendency of α‐synuclein: An in‐solution and in‐silico study	3
Sexually dimorphic metal alterations in childhood obesity are modulated by a complex interplay between inflammation, insulin, and sex hormones	3
Suppression of colorectal cancer growth: Interplay between curcumin and metformin through DMT1 downregulation and ROS	3
Trihydroxylated Anthocyanins Potentiate Effects of Docetaxel in Mesenchymal Triple Negative Breast Cancer Cells	3
Coenzyme Q10 Mitigates Myocardial Infarction by Modulating HDAC4 O‐ GlcNA	3
Issue Information	3