Biofactors

Article	Citations
Issue Information	93
Formation of Plant Derived Bioactive Peptides During Simulated Gastro‐Intestinal Digestion: A Systematic Review	72
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Attenuation of p38 MAPK / NF ‐ κB /	58
Investigating rutin as a potential transforming growth factor‐β type I receptor antagonist for the inhibition of bleomycin‐induced lung fibrosis	57
Diverse Inhibitors of De Novo Purine Synthesis Promote AICAR ‐Induced AMPK Activation and Glucose	52
Issue Information	51
Hydroethanolic Soy Extract Rich in Isoflavones Protects Dystrophic Mutant Mice From Oxidative Stress and Inflammation via the ROS /	50
Long‐Term Intake of Oleic Acid‐Rich Palm Oil Induces Obesity Without Impairing Hypothalamic Insulin Sensitivity and Redox Activity in Male Wistar Rats	41
Issue Information	40
Retraction	39
Lactate dehydrogenase A is implicated in the pathogenesis of B‐cell lymphoma through regulation of the FER signaling pathway	38
Delving Into the Multifaceted Role of Exosomal Cargo in Kidney Diseases: Mechanistic Pathways, Diagnostic Potential, and Therapeutic Applications	36
Long non‐coding RNA LINC01224 plays an oncogenic role in endometrial cancer via miR ‐4673/	36
The Role of STAT3 in Cancer: From Metabolic Regulation to Therapeutic Targeting	35
Endogenously produced hyaluronan contributes to the regulation of peritoneal adhesion development	35
Issue Information ‐ Cover	35
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR‐7/m‐TOR/SREBP1 pathway on prostate cancer	34
The possible role of the nucleoside adenosine in countering skin aging: A review	31
Adipose tissue‐derived mesenchymal stem cells ameliorate cognitive impairment in Alzheimer's disease rat model: Emerging role ofSIRT1	31
The endocannabinoidome in human placenta: Possible contribution to the pathogenesis of preeclampsia	30
Knockdown of integrin β1 inhibits proliferation and promotes apoptosis in bladder cancer cells	29
Correction to “Zerumbone, a ginger sesquiterpene, inhibits migration, invasion, and metastatic behavior of human malignant glioblastoma multiforme in vitro”	28
N ‐methyl‐ d ‐aspartate receptors: Structure , function, and role in or	28
AND ‐1 Enhances Erastin‐Induced Ferroptosis in Ovarian Cancer Cells by Down‐Regulating SLC7A11 and	27

SEMI ‐1, A Novel Neuronal Selenium‐Binding Protein 1 Homolog Without Methanethiol Oxidase Activity, Modulates Stress Resistance, Lifespan, and Thermotaxis in	27
Berberine chloride loaded nano‐ PEGylated liposomes attenuates imidacloprid‐induced neurotoxicity by inhibiting NLRP3	26
Rosa gallica and its active compound, cyanidin‐3,5‐O‐diglucoside, improve skin hydration via the GLK signaling pathway	25
The neuropeptide substance P/neurokinin‐1 receptor system and diabetes: From mechanism to therapy	24
Circular RNAs in Cancer: Epigenetic Regulation, Dual Functions and Clinical Translation	24
Crocetin regulates Th1/Th2 and Th17/Treg balances, nitric oxide production, and nuclear localization of NF‐κB in Th2‐provoked and norm	22
High glucose leads to redistribution of the proteasomal system	22
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Issue Information ‐ Cover	22
Deletion of NRF2 disturbs composition, morphology, and differentiation of the murine tail epidermis in chronological aging	22
Retraction	22
Modulatory Effect of Natural Antioxidants on Tissue Transglutaminase Levels in Olfactory Ensheathing Cells Exposed to Amyloid‐β: Integrated Biochemical and Computational Analysis	21
The in vitro anti‐cancer synergy of neurokinin‐1 receptor antagonist, aprepitant, and 5‐aminolevulinic acid in glioblastoma	21
Bitter yet beneficial: The dual role of dietary alkaloids in managing diabetes and enhancing cognitive function	21
Control of Mycobacterium tuberculosis infection in the elderly: Is there a role for epigenetic reprogramming reversal?	21
Melatonin protects Kir2.1 function in an oxidative stress‐related model of aging neuroglia	20
Protein concentrations and activities of fatty acid desaturase and elongase enzymes in liver, brain, testicle, and kidney from mice: Substrate dependency	20
Deciphering the role of Zn2+‐binding histidines from TIA‐1 on the assembly and dynamics of stress granules	20
Dietary limonene promotes gastrointestinal barrier function via upregulating tight/adherens junction proteins through cannabinoid receptor type‐1 antagonistic mechanism and alters cellular metabolism	20
A novel peptide derived from Haematococcus pluvialis residue balanced lipid metabolism through NHR‐49/PPARα and AAK‐2/AMPK pathways in Caenorhabdi	20
Issue Information	19
Agmatine suppresses glycolysis via the PI3K /Akt/ mTOR / HIF	19
Issue Information	19
Deubiquitinase PSMD14 promotes tumorigenicity of glioblastoma by deubiquitinating and stabilizing β‐catenin	18
Issue Information ‐ Cover	18
Proteomic profiling of intestinal epithelial‐like cell‐derived exosomes regulated by epigallocatechin gallate	18
Issue Information ‐ Cover	18
Oleuropein Aglycone Modulates Oxidative Stress and Autophagy‐Related Pathways in Human Skeletal Muscle Cells	18
Integrative Multi‐Omics Analysis Reveals the Tumor‐Suppressive and Immunoregulatory Roles of SEMA5B in Prostate Cancer	17
A new strategy for screening novel functional genes involved in reduction of lipid droplet accumulation	17
Piperine: an emerging biofactor with anticancer efficacy and therapeutic potential	17
Effects of calciprotein particles on EMT induction in an in vitro 3D‐cultured proximal tubule epithelial cell model of CKD	17
Corrigendum to “Fucosterol Promotes Browning in Mouse 3T3‐L1 AdipocytesThrough HO‐1/Nrf2 and AMPK Pathways”	17
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Gut microbiota contribution to selenium deficiency‐induced gut–liver inflammation	16
Issue Information	16
SP1/CTR1 ‐mediated oxidative stress‐induced cuproptosis in intervertebral disc degeneration	16
Correction to “Inhibition of succinate dehydrogenase sensitizes cyclin E‐driven ovarian cancer to CDK inhibition”	15
Issue Information	15
Retraction	15
Non‐beneficial effects of resveratrol on renal epithelial cell cultures: Implications in cell differentiation	15
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Navigating the immune landscape with plasma cells: A pan‐cancer signature for precision immunotherapy	14
Harnessing tumor‐derived exosomes: A promising approach for the expansion of clinical diagnosis, prognosis, and therapeutic outcome of prostate cancer	14
Echinacoside promotes collagen synthesis and survival via activation of IGF ‐1 signaling to alleviate UVB	14
Vitamin D modulates the content of inflammatory microRNAs in extracellular vesicles from human adipocyte cells in inflammatory context	14
Nuclear receptor 4A1 (NR4A1) upregulated by n ‐butylidenephthalide via the mitogen‐activated protein kinase (	13
Mesenchymal Stem Cell‐Derived Exosomal miR ‐29a‐3p Improves Hypertrophic Scar by Inhibiting the Proliferation and Migration of Schwann Cells via the	13
Dauriporphine Inhibits the Proliferation, Migration, Angiogenesis, and Glycolysis in Lung Cancer Cells by Repressing PGK1 Expression via	13
Zerumbone Induced ROS ‐Mediated Autophagic Cell Death in Human Melanoma Cells: An In Vitro and In Vivo Study	13

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Insights into an indolicidin‐derived low‐toxic anti‐microbial peptide's efficacy against bacterial cells while preserving eukaryotic cell viability	13
Leveraging supramolecular systems in biomedical breakthroughs	12
Clock system disruption in male Fischer 344 rats fed cafeteria diet and administered sweet treats at different times: The zeitgeber role of grape seed fl	12
Erratum to “Revisiting the therapeutic potential of tocotrienol”	12
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Retraction	12
Extracellular vesicles (EVs): A promising therapeutic tool in the heart tissue regeneration	12
Crocus sativus tepals extract suppresses subcutaneous adipose tissue hypertrophy and improves systemic insulin sensitivity in mice on high‐fat diet	12
miR‐222 exerts negative regulation on insulin signaling pathway in 3T3‐L1 adipocytes	12
Multi‐Targeted Anti‐Diabetic Effects of Trifuhalol A From Edible Seaweed via Glycation Inhibition, Glucose Uptake Enhancement and Pancreatic Islet Protection	11
The role of LncRNA‐regulated autophagy in AKI	11
UPS and Kinases—Gatekeepers of the G1/S Transition	11
Combinatorial effect of Apigenin‐resveratrol on white adipocyte plasticity and trans‐differentiation for activating lipid metabolism	11
A Di‐Rhamnolipid (Rha 2 ‐ C 10	11
Identification and validation of the TRHDE‐AS1 / hsa‐miR ‐449a/ ADAMTS5	10
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Piperlongumine Triggers Reactive Oxygen Species Driven Mitochondrial Dysfunction Leading to Apoptosis in Human Colon Cancer Cells	10
Pulp Callus Extract From Malus domestica var. Mela Rosa Marchigiana Preserves Intestinal Barrier Integrity and Confers Neuroprotection in a Gut–Brain Axi	10
Garcinia gummi‐gutta: Phytochemicals and pharmacological applications	9
The Function and Supramolecular Assembly of the Mitochondrial Respiratory Complexes Underlie Hypertension‐Related Stroke Susceptibility in a Model of Complex Human Disease	9
BACE1 : Biological Functions and Involvement in the Pathophysiology of Alzheimer's Disease and Other Neurological Disorders	9
Lignans Alleviate Depression by Modulating the Gut–Brain Axis: Effect and Mechanism Based on Multi‐Omics Analyses	9
Scent Goes Digital: The Role of Insect Odorant Binding Proteins in Modern Technology	9
Correction to EVs Biodistribution and Antifibrotic Impact in Aged Lung Fibrosis Model	9
Correction to “Knockdown of Integrin β1 Inhibits Proliferation and Promotes Apoptosis in Bladder Cancer Cells”	9
Bromelain Alleviates 3‐Nitropropionic Acid‐Induced Huntington's Disease‐Like Symptoms in Rats Through the Interplay of SIRT1 /	9
Therapeutic potential of phytochemicals for cystic fibrosis	9
Bioaccessible Sulforaphane Drives Macrophage Migration and Differentiation by Reprogramming the Interleukin Profile in Intestinal Inflammation	8
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Blueberry intervention mitigates detrimental microbial metabolite trimethylamine N‐oxide by modulating gut microbes	8
Cannabinoids in neuroinflammatory disorders: Focusing on multiple sclerosis, Parkinsons, and Alzheimers diseases	8
The Nuclear Face of PTEN : Implications in Cancer Prognosis and Targeted Therapy	8
Fermented Cabbage Brine as a Functional Dietary Modulator of Neuroinflammation, Oxidative Stress, and Anxiety‐Like Behavior in Lipopolysaccharide‐Challenged Mice	8
Mechanisms of cancer cell death induction by triptolide	8
Andrographolide Promotes Ferroptosis in Pancreatic Cancer via Targeting and Activating HSP90 / GPX4	8
Resolvin D1: A key endogenous inhibitor of neuroinflammation	8
Retraction	8
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Gut Microbial Metabolite Crosstalk in Crohn's Disease: Network Pharmacology Unveils Dual‐Axis Pathogenesis and Therapeutic Targets	8
Issue Information ‐ Cover	8
ISG15 Mediates Oxidative Stress Modulation in T2DM Patients by Directly Targeting PIK3R2	8
Issue Information ‐ Cover	8
Torpor‐responsive microRNAs in the heart of the Monito del monte, Dromiciops gliroides	8
Fucosterol Promotes Browning in Mouse 3T3 ‐ L1 Adipocytes Through HO	8
Issue Information ‐ Cover	8
Molecular Extremes of Ovarian Response: Divergent PI3K / AKT / mTOR	8
Correction to “Untargeted metabolomics reveals biomarkers for the diagnosis of coronary artery plaques as observed by coronary cardiac computed tomography”	8
Issue Information ‐ Cover	7
Crosstalk among miR ‐29, α‐SMA , and TGFβ1 /β3	7
Platelet‐activating factor and microvesicle particles as potential mediators for the toxicity associated with intoxicated thermal burn injury	7
Machine learning‐derived peripheral blood transcriptomic biomarkers for early lung cancer diagnosis: Unveiling tumor‐immune interaction mechanisms	7
Therapeutic Potential of Resveratrol in Cancer and Neurodegenerative Disorders: A Current Review	7
Jagged1‐Fluc: A Luminescent Recombinant Protein as a Sensitive Tool for High‐Throughput Screening of Colorectal Cancer	7
DISC1 inhibits GSK3β activity to prevent tau hyperphosphorylation under diabetic encephalopathy	7
Retraction	7
Isolation and characterization of N‐(2‐Hydroxyethyl)hexadecanamide from Colletotrichum gloeosporioides with apoptosis‐inducing potential in breast cancer cells	7
Deep Learning‐Driven Enzyme Engineering in Pichia pastoris : A Sustainable Platform for High‐Yield Nootkatone Biosynthesis	7
Altered rich‐club organization of brain functional network in autism spectrum disorder	7
Issue Information	7
The interlacing anticancer effect of pharmacologic ascorbate, chloroquine, and resveratrol	7
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Trace elements as potential modulators of puberty‐induced amelioration of oxidative stress and inflammation in childhood obesity	7
Unlocking the Antiadipogenic Potential of Carotenoids From Galdieria phlegrea	6
Correction to “Bioactive Peptides in Preterm Human Milk: Impact of Maternal Characteristics and Their Association to Neonatal Outcomes”	6
O ‐ GlcNAcylation regulates osteoblast differentiation through the morphological changes in mitochondria, cytoskeleton, an	6
Multi‐Omics Analysis and Mechanistic Validation Reveal RPS8 as a Novel Prognostic Biomarker and Therapeutic Target for Hepatocellular Carcinoma	6
Ameliorating diabetes‐induced testicular dysfunction by modulating PKC/Nrf2/Bcl‐2 signaling: Protective role of sulbutiamine	6
An AI ‐Driven Multi‐Omics Framework Identifies CASP8 as a Clinically Actionable Pyroptosis Biomark	6
Neuroprotective Effects of SELFormer ‐Selected β‐Citronellol and β‐Caryophyllene in Vagotomized Ischemic Stroke Model Through Direct Brain Protection	6
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Planning the new phase of BioFactors: An IUBMB journal	6
The influence of apigenin on cellular responses to radiation: From protection to sensitization	6
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Reduced iron and cobalt levels in response to curcumin supplementation are not responsible for the prolonged larval development and do not affect the oxidative stress tolerance and polyamine status of	6
The role of PAF in immunopathology: From immediate hypersensitivity reactions to fungal defense	6
Lobaric acid suppresses the stemness potential of colorectal cancer cells through mTOR / AKT	6
Oxidized phospholipids and lipoprotein‐associated phospholipase A2 (Lp‐PLA2) in atherosclerotic cardiovascular disease: An update	6
Resolvins protect against diabetes‐induced colonic oxidative stress, barrier dysfunction, and associated diarrhea via the HO ‐1 pathway	6
Oral Administration of Crocus sativus Tepals Extract Restores High‐Fat Diet‐Induced Gut Dysbiosis and Modulates Intestinal Inflammation and Hepatic Lipid	5

Integrative multi‐omic and machine learning approach for prognostic stratification and therapeutic targeting in lung squamous cell carcinoma	5
Issue Information	5
The role of NRF2 transcription factor in inflammatory skin diseases	5
Resveratrol‐Derived Dimers With Antimicrobial and Immune‐Enhancing Activities	5
Anticancer effect of minor phytocannabinoids in preclinical models of multiple myeloma	5
Bioactive dietary components—Anti‐obesity effects related to energy metabolism and inflammation	5
Platelet‐activating factor as an endogenous cofactor of food anaphylaxis	5
High‐fat diet induced obesity promotes inflammation, oxidative stress, and hepatotoxicity in female FVB/N mice	5
Topical application of gemcitabine generates microvesicle particles in human and murine skin	5
Morin overcomes doxorubicin resistance in human breast cancer by inducing DNA damage and modulating the LKB1	5
Sacubitril/valsartan promotes white adipose tissue browning in rats with metabolic syndrome through activation of mTORC1	5
Melatonin mediated activation of MAP kinase pathway may reduce DNA damage stress in plants: A review	5
Profiling of RUVBL2 ‐Induced Transcriptome Alterations Highlights a Critical Role for Chromatin Remodeling in Ovarian Cancer	5
The in vitro and in vivo skin‐whitening activity of Ectoine through enhanced autophagy in melanocytes and keratinocytes and zebrafish model	5
Effect of High Hydrostatic Pressure ( HHP ) on the Enzymatic Hydrolysis of Fish Gelatin	5
HSP27 Promotes Cutaneous Squamous Cell Carcinoma Progression by Inhibiting Ferroptosis	5
Pax‐8: Molecular biology, pathophysiology, and potential pathogenesis	5
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The Potential Role of Matrix Metalloproteinase in Polycystic Ovary Syndrome: Implications for Extracellular Matrix Remodeling	5
Possible mitigating effect of adropin on lung injury in diabetic rats: Targeting the role of Rho A/Rho‐associated kinase pathway	4
Investigate the metabolic changes in intestinal diseases by employing a 1 H	4
Fingernail Mineral Profiling as a Non‐Invasive Tool to Assess Dietary and Lifestyle Factors: Results From the Cross‐Sectional Fulda NutriNAIL Study	4
Platelet Activating Factor (PAF): A Mediator of Inflammation	4
Dietary carbohydrates: Pathogenesis and potential therapeutic targets to obesity‐associated metabolic syndrome	4
Issue Information	4
Inhibition of glioblastoma proliferation, invasion, and migration by Urolithin B through inducing G0/G1 arrest and targeting MMP‐2/‐9 expression and activity	4
The role of P450 enzymes in malaria and other vector‐borne infectious diseases	4
CEP55 Drives Pancreatic Cancer Progression by Suppressing Ferroptosis	4
Investigating the impact of Ras‐related protein RAB7A on colon adenocarcinoma behavior and its clinical significance	4
OSBPL10‐CNBP axis mediates hypoxia‐induced pancreatic cancer development	4
Translational aspect in peptide drug discovery and development: An emerging therapeutic candidate	4
Impact of Cellular Senescence on LCN2 Expression in Salivary Gland Epithelial Cells and Oral Keratinocytes	4
Taurine rescues pancreatic β‐cell stress by stimulating α‐cell transdifferentiation	4
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Natural Product Daidzin Inhibits Glioma Development via Suppressing the LRP5‐Mediated GSK‐3β/c‐Myc Signaling Pathway	4
Hexokinase 2‐Driven Cardioprotection in Ischemia, Hypertrophy, and Regeneration: From Underlying Mechanisms to Clinical Translation	4
Preface	4
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The Therapeutic Potential of Flavonols in Alzheimer's Disease: Inhibiting Amyloid‐β, Oxidative Stress, and Neuroinflammation	4
Protein kinase CK2: An emerging regulator of cellular metabolism	4
The flavonoid quercetin decreases ACE2 and TMPRSS2 expression but not SAR	4
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Retraction	4
Artificial Intelligence for Detection of Parkinson's Disease From Speech Signals—A Comprehensive Review	3
Sexually dimorphic metal alterations in childhood obesity are modulated by a complex interplay between inflammation, insulin, and sex hormones	3
A Comprehensive Insight Into the Roles of Exosomal circRNAs in Metabolic Syndrome	3
Issue Information	3
Mitochondria‐Targeting SIRT3 Activator Effectively Controls Bleomycin‐Induced Pulmonary Fibrosis	3
Is There an Ace Up One's Sleeve in the Preanalytical Phase of the Circulating Tumor DNA Analysis?	3
Suppression of colorectal cancer growth: Interplay between curcumin and metformin through DMT1 downregulation and ROS	3
Vasoactive intestinal peptide exerts an osteoinductive effect in human mesenchymal stem cells	3
Antioxidant, anti‐inflammatory and epigenetic potential of curcumin in Alzheimer's disease	3
Weighing the Benefits of Improving the Iron Status Against the Risk of Overload—A Narrative Review on Oral Iron Supplementation in Premenopausal Women	3
Pathophysiology of Endoplasmic Reticulum Stress and the Potential Role of Dexmedetomidine as a Modulator	3
Untargeted metabolomics reveals biomarkers for the diagnosis of coronary artery plaques as observed by coronary cardiac computed tomography	3
Catechol‐induced covalent modifications modulate the aggregation tendency of α‐synuclein: An in‐solution and in‐silico study	3
Coenzyme Q10 Mitigates Myocardial Infarction by Modulating HDAC4 O‐ GlcNA	3
Tau, tau kinases, and tauopathies: An updated overview	3
Treatment of the metabolic syndrome by siRNA targeting apolipoprotein CIII	3
Integration of miRNA in exosomes and single‐cell RNA‐seq profiles in endemic osteoarthritis, Kashin–Beck disease	3
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Fabp5 Is the Key Regulator Mediating γ‐ CEHC Differentiation in Osteoblasts and Osteoclasts	3
Salvia hispanica L. (chia) seed improves redox state and reverts extracellular matrix collagen deposition in skeletal muscle of sucrose‐rich diet‐fed rats	3
Blockade of PD‐1 and CTLA‐4: A potent immunotherapeutic approach for hepatocellular carcinoma	3
Trihydroxylated Anthocyanins Potentiate Effects of Docetaxel in Mesenchymal Triple Negative Breast Cancer Cells	3
Deciphering potential molecular mechanisms in clear cell renal cell carcinoma based on the ubiquitin‐conjugating enzyme E2 related genes: Identifying	3