OOIR: Observatory of International Research

Papers

(The TQCC of Biofactors is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Issue Information	336
Issue Information	86
Investigating rutin as a potential transforming growth factor‐β type I receptor antagonist for the inhibition of bleomycin‐induced lung fibrosis	59
New biomarkers and therapeutic targets of human liver cancer: Transcriptomic findings	58
Reactive oxygen species as a double‐edged sword: The role of oxidative enzymes in antitumor therapy	57
	54
Myasthenia gravis: The pharmacological basis of traditional Chinese medicine for its clinical application	53
Golgi stress response: A regulatory mechanism of Golgi function	50
Attenuation of p38 MAPK/NF‐κB/TRPV1/CGRP is involved in the antinociceptive effect of hesperidin methyl chalcone and taxifolin in paclitaxel‐indu	49
Long‐Term Intake of Oleic Acid‐Rich Palm Oil Induces Obesity Without Impairing Hypothalamic Insulin Sensitivity and Redox Activity in Male Wistar Rats	48
Long non‐coding RNA LINC01224 plays an oncogenic role in endometrial cancer via miR‐4673/TPX2 axis and activating Wnt/β‐catenin signaling pathway	47
Retraction	47
Recent research progress of biologically active peptides	45
Lactate dehydrogenase A is implicated in the pathogenesis of B‐cell lymphoma through regulation of the FER signaling pathway	38
Is there an interplay between the SARS‐CoV‐2 spike protein and Platelet‐Activating factor?	38
Endogenously produced hyaluronan contributes to the regulation of peritoneal adhesion development	37
SEMO‐1, a novel methanethiol oxidase in Caenorhabditis elegans, is a pro‐aging factor conferring selective stress resistance	36
Rosa gallica and its active compound, cyanidin‐3,5‐O‐diglucoside, improve skin hydration via the GLK signaling pathway	35
The endocannabinoidome in human placenta: Possible contribution to the pathogenesis of preeclampsia	32
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR‐7/m‐TOR/SREBP1 pathway on prostate cancer	32
N‐methyl‐d‐aspartate receptors: Structure, function, and role in organophosphorus compound poisoning	31
The possible role of the nucleoside adenosine in countering skin aging: A review	29
Adipose tissue‐derived mesenchymal stem cells ameliorate cognitive impairment in Alzheimer's disease rat model: Emerging role ofSIRT1	29
Correction to “Zerumbone, a ginger sesquiterpene, inhibits migration, invasion, and metastatic behavior of human malignant glioblastoma multiforme in vitro”	29
Berberine chloride loaded nano‐PEGylated liposomes attenuates imidacloprid‐induced neurotoxicity by inhibiting NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis	28

Issue Information ‐ Cover	28
Knockdown of integrin β1 inhibits proliferation and promotes apoptosis in bladder cancer cells	27
The neuropeptide substance P/neurokinin‐1 receptor system and diabetes: From mechanism to therapy	27
Three months of combination therapy with nano‐curcumin reduces the inflammation and lipoprotein (a) in type 2 diabetic patients with mild to moderate coronary artery disease: Evidence of a randomized,	27
Retraction	26
Promising effects of gingerol against toxins: A review article	25
Melatonin protects Kir2.1 function in an oxidative stress‐related model of aging neuroglia	25
Crocetin regulates Th1/Th2 and Th17/Treg balances, nitric oxide production, and nuclear localization of NF‐κB in Th2‐provoked and norm	24
	24
Deletion of NRF2 disturbs composition, morphology, and differentiation of the murine tail epidermis in chronological aging	23
The in vitro anti‐cancer synergy of neurokinin‐1 receptor antagonist, aprepitant, and 5‐aminolevulinic acid in glioblastoma	23
Exosomal lnc‐AFTR as a novel translation regulator of FAS ameliorates Staphylococcus aureus‐induced mastitis	23
Deciphering the role of Zn²⁺‐binding histidines from TIA‐1 on the assembly and dynamics of stress granules	23
High glucose leads to redistribution of the proteasomal system	22
Tangeretin promotes lifespan associated with insulin/insulin‐like growth factor‐1 signaling pathway and heat resistance in Caenorhabditis elegans	21
Issue Information ‐ Cover	20
Control of Mycobacterium tuberculosis infection in the elderly: Is there a role for epigenetic reprogramming reversal?	20
Bitter yet beneficial: The dual role of dietary alkaloids in managing diabetes and enhancing cognitive function	20
Agmatine suppresses glycolysis via the PI3K/Akt/mTOR/HIF‐1α signaling pathway and improves mitochondrial function in microglia exposed to lipopolysaccharide	20
Redox‐sensitive signaling pathways in renal cell carcinoma	19
A novel peptide derived from Haematococcus pluvialis residue balanced lipid metabolism through NHR‐49/PPARα and AAK‐2/AMPK pathways in Caenorhabdi	19
Dietary limonene promotes gastrointestinal barrier function via upregulating tight/adherens junction proteins through cannabinoid receptor type‐1 antagonistic mechanism and alters cellular metabolism	19
Issue Information	18
Issue Information	18
A pilot study of the effects of crocin on high‐density lipoprotein cholesterol uptake capacity in patients with metabolic syndrome: A randomized clinical trial	18
Protein concentrations and activities of fatty acid desaturase and elongase enzymes in liver, brain, testicle, and kidney from mice: Substrate dependency	18
Issue Information ‐ Cover	17
Issue Information ‐ Cover	17
Deubiquitinase PSMD14 promotes tumorigenicity of glioblastoma by deubiquitinating and stabilizing β‐catenin	16
	16
Proteomic profiling of intestinal epithelial‐like cell‐derived exosomes regulated by epigallocatechin gallate	16
Molecular mechanisms involved in the effects of morin in experimental hepatic encephalopathy	16
Piperine: an emerging biofactor with anticancer efficacy and therapeutic potential	16
Issue Information	16
Protective effect of luteolin against chemical and natural toxicants by targeting NF‐κB pathway	15
Maternal erythrocyte fatty acid composition as a predictive marker for pregnancy health	15
SP1/CTR1‐mediated oxidative stress‐induced cuproptosis in intervertebral disc degeneration	15
Erratum	15
A new strategy for screening novel functional genes involved in reduction of lipid droplet accumulation	15
Correction to “Inhibition of succinate dehydrogenase sensitizes cyclin E‐driven ovarian cancer to CDK inhibition”	14
Gut microbiota contribution to selenium deficiency‐induced gut–liver inflammation	14
Retraction	14
Effects of calciprotein particles on EMT induction in an in vitro 3D‐cultured proximal tubule epithelial cell model of CKD	14
Issue Information	14
Targeting of the tumor microenvironment by curcumin	14
	13
Harnessing tumor‐derived exosomes: A promising approach for the expansion of clinical diagnosis, prognosis, and therapeutic outcome of prostate cancer	13
Effects of berbamine against myocardial ischemia/reperfusion injury: Activation of the 5' adenosinemonophosphate‐activatedprotein kinase/nuclear factor erythroid2‐relatedfactor p	13
Vitamin D modulates the content of inflammatory microRNAs in extracellular vesicles from human adipocyte cells in inflammatory context	13
Nuclear receptor 4A1 (NR4A1) upregulated by n‐butylidenephthalide via the mitogen‐activated protein kinase (MAPK) pathway ameliorates drug‐induced gingival enlargement	13

Echinacoside promotes collagen synthesis and survival via activation of IGF‐1 signaling to alleviate UVB‐induced dermal fibroblast photoaging	13
	12
Dioscin: A review on pharmacological properties and therapeutic values	12
	12
Non‐beneficial effects of resveratrol on renal epithelial cell cultures: Implications in cell differentiation	12
Navigating the immune landscape with plasma cells: A pan‐cancer signature for precision immunotherapy	12
Insights into an indolicidin‐derived low‐toxic anti‐microbial peptide's efficacy against bacterial cells while preserving eukaryotic cell viability	12
UPS and Kinases—Gatekeepers of the G1/S Transition	11
Identification and validation of the TRHDE‐AS1/hsa‐miR‐449a/ADAMTS5 axis as a novel prognostic biomarker in prostate cancer	11
Retraction	11
Crocus sativus tepals extract suppresses subcutaneous adipose tissue hypertrophy and improves systemic insulin sensitivity in mice on high‐fat diet	11
Clock system disruption in male Fischer 344 rats fed cafeteria diet and administered sweet treats at different times: The zeitgeber role of grape seed flavanols	11
Erratum to “Revisiting the therapeutic potential of tocotrienol”	11
Combinatorial effect of Apigenin‐resveratrol on white adipocyte plasticity and trans‐differentiation for activating lipid metabolism	11
The role of LncRNA‐regulated autophagy in AKI	11
miR‐222 exerts negative regulation on insulin signaling pathway in 3T3‐L1 adipocytes	11
Extracellular vesicles (EVs): A promising therapeutic tool in the heart tissue regeneration	11
Correction to EVs Biodistribution and Antifibrotic Impact in Aged Lung Fibrosis Model	10
	10
FERM domain‐containing protein 6 exerts a tumor‐inhibiting role in thyroid cancer by antagonizing oncogenic YAP1	10
miR‐23b/TAB3/NF‐κB/p53 axis is involved in hippocampus injury induced by cerebral ischemia–reperfusion in rats: The protective effect of chlorogenic acid	10
	10
Mechanisms of cancer cell death induction by triptolide	10
Therapeutic potential of phytochemicals for cystic fibrosis	10
Leveraging supramolecular systems in biomedical breakthroughs	10
Issue Information	9
Garcinia gummi‐gutta: Phytochemicals and pharmacological applications	9
Issue Information ‐ Cover	9
Issue Information ‐ Cover	9
Correction to “Untargeted metabolomics reveals biomarkers for the diagnosis of coronary artery plaques as observed by coronary cardiac computed tomography”	9
Issue Information ‐ Cover	9
Fucosterol Promotes Browning in Mouse 3T3‐L1 Adipocytes Through HO‐1/Nrf2 and AMPK Pathways	9
Autophagy flux inhibition mediated by lysosomal dysfunction participates in the cadmium exposure‐induced cardiotoxicity in swine	8
Carboxylative efficacy of trans and cisMK7 and comparison with other vitamin K isomers	8
Retraction	8
Noninvasive instrumental evaluation of coenzyme Q₁₀ phytosome on endothelial reactivity in healthy nonsmoking young volunteers: A double‐blind, randomized, placebo‐controlled cro	8
Blueberry intervention mitigates detrimental microbial metabolite trimethylamine N‐oxide by modulating gut microbes	8
Issue Information ‐ Cover	8
Cannabinoids in neuroinflammatory disorders: Focusing on multiple sclerosis, Parkinsons, and Alzheimers diseases	8
Melatonin ameliorates trimethyltin chloride‐induced cardiotoxicity: The role of nuclear xenobiotic metabolism and Keap1‐Nrf2/ARE axis‐mediated pyroptosis	8
Altered rich‐club organization of brain functional network in autism spectrum disorder	8
Nrf2 driven macrophage responses in diverse pathophysiological contexts: Disparate pieces from a shared molecular puzzle	8
Resolvin D1: A key endogenous inhibitor of neuroinflammation	8
Issue Information ‐ Cover	8
Torpor‐responsive microRNAs in the heart of the Monito del monte, Dromiciops gliroides	8
Gut microbiome–micronutrient interaction: The key to controlling the bioavailability of minerals and vitamins?	8
DISC1 inhibits GSK3β activity to prevent tau hyperphosphorylation under diabetic encephalopathy	8
Crosstalk among miR‐29, α‐SMA, and TGFβ1/β3 in melatonin‐induced exosome (Mel‐prExo) treated human limbal mesenchymal stem cells (hLMSCs): An ins	8