OOIR: Observatory of International Research

Papers

(The TQCC of Biofactors is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Luteolin as a modulator of skin aging and inflammation	143
The role of plant‐derived natural antioxidants in reduction of oxidative stress	130
Long‐COVID syndrome‐associated brain fog and chemofog: Luteolin to the rescue	130
Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma	121
Experimental and clinical reports on anti‐inflammatory, antioxidant, and immunomodulatory effects of Curcuma longa and curcumin, an updated and comprehensive review	75
Protection against Alzheimer's disease by luteolin: Role of brain glucose regulation, anti‐inflammatory activity, and the gut microbiota‐liver‐brain axis	68
COVID‐19, microthromboses, inflammation, and platelet activating factor	51
Luteolin, inflammation and cancer: Special emphasis on gut microbiota	45
Perspectives in liver redox imbalance: Toxicological and pharmacological aspects underlying iron overloading, nonalcoholic fatty liver disease, and thyroid hormone action	40
Mitochondrial dysfunction and endoplasmic reticulum stress in the promotion of fibrosis in obstructive nephropathy induced by unilateral ureteral obstruction	40
Targeting of the tumor microenvironment by curcumin	37
Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals	35
Gut microbiome–micronutrient interaction: The key to controlling the bioavailability of minerals and vitamins?	34
Phytochemicals impact on osteogenic differentiation of mesenchymal stem cells	32
Medicinal plants and bioactive natural compounds as inhibitors of HMG‐CoA reductase: A literature review	31
The cardioprotective effects of nano‐curcumin against doxorubicin‐induced cardiotoxicity: A systematic review	30
Ischemic stroke, obesity, and the anti‐inflammatory role of melatonin	30
The role of phytochemicals in sepsis: A mechanistic and therapeutic perspective	30
Cyanidin‐3‐O‐glucoside attenuates endothelial cell dysfunction by modulating miR‐204‐5p/SIRT1‐mediated inflammation and apoptosis	30
Circular RNA DOCK1 downregulates microRNA‐124 to induce the growth of human thyroid cancer cell lines	29
Targeting lactate metabolism and glycolytic pathways in the tumor microenvironment by natural products: A promising strategy in combating cancer	29
Quercetin prevents cadmium chloride‐induced hepatic steatosis and fibrosis by downregulating the transcription of miR‐21	28
Resolvin D1 protects against sepsis‐induced cardiac injury in mice	28
Dihydroartemisinin alleviates hepatic fibrosis through inducing ferroptosis in hepatic stellate cells	28
Dioscin: A review on pharmacological properties and therapeutic values	25

Interactions between dietary polyphenols and aging gut microbiota: A review	25
Curcumin: A small molecule with big functionality against amyloid aggregation in neurodegenerative diseases and type 2 diabetes	25
Nerolidol protects the liver against cyclophosphamide‐induced hepatic inflammation, apoptosis, and fibrosis via modulation of Nrf2, NF‐κB p65, and caspase‐3 signaling molecules in Swiss alb	24
A mechanistic review on immunomodulatory effects of selective type two cannabinoid receptor β‐caryophyllene	24
Platelet Activating Factor (PAF): A Mediator of Inflammation	24
Exosomal LINC01005 derived from oxidized low‐density lipoprotein‐treated endothelial cells regulates vascular smooth muscle cell phenotypic switch	24
Neuroinflammation in Alzheimer's disease and beneficial action of luteolin	23
Polyphenols as modulators of pre‐established gut microbiota dysbiosis: State‐of‐the‐art	23
Three months of combination therapy with nano‐curcumin reduces the inflammation and lipoprotein (a) in type 2 diabetic patients with mild to moderate coronary artery disease: Evidence of a randomized,	22
Ginger and its constituents: Role in treatment of inflammatory bowel disease	22
LncRNA H19 aggravates TNF‐α‐induced inflammatory injury via TAK1 pathway in MH7A cells	21
Secondary CoQ₁₀ deficiency, bioenergetics unbalance in disease and aging	21
The HIF‐1/SNHG1/miR‐199a‐3p/TFAM axis explains tumor angiogenesis and metastasis under hypoxic conditions in breast cancer	21
Powerful anti‐inflammatory action of luteolin: Potential increase with IL‐38	21
Promising effects of gingerol against toxins: A review article	21
A pilot study of the effects of crocin on high‐density lipoprotein cholesterol uptake capacity in patients with metabolic syndrome: A randomized clinical trial	20
Berberine promotes peri‐implant osteogenesis in diabetic rats by ROS‐mediated IRS‐1 pathway	20
An assessment of poly (ADP‐ribose) polymerase‐1 role in normal and cancer cells	19
C. elegansACAT regulates lipolysis and its related lifespan in fasting through modulation of the genes in lipolysis and insulin/IGF‐1 signaling	19
Selenium deficiency causes apoptosis through endoplasmic reticulum stress in swine small intestine	19
Effect of nano‐curcumin on various diseases: A comprehensive review of clinical trials	19
Revisiting the therapeutic potential of tocotrienol	19
Specialized proresolving mediators in infection and lung injury	19
The roles of melatonin on kidney injury in obese and diabetic conditions	18
Exosomal lnc‐AFTR as a novel translation regulator of FAS ameliorates Staphylococcus aureus‐induced mastitis	18
Catalase deficiency induces reactive oxygen species mediated pexophagy and cell death in the liver during prolonged fasting	17
Protein networks linking Warburg and reverse Warburg effects to cancer cell metabolism	17
Translational aspect in peptide drug discovery and development: An emerging therapeutic candidate	16
Systemic inflammation and oxidative stress induced by inhaled paraquat in rat improved by carvacrol, possible role of PPARγ receptors	16
Ginger: A complementary approach for management of cardiovascular diseases	16
Analytical determinations of luteolin	16
Stem cell‐based therapies for cardiac diseases: The critical role of angiogenic exosomes	16
Zinc and gut microbiota in health and gastrointestinal disease under the COVID‐19 suggestion	15
Anti‐neuroinflammatory effect of daidzein in human hypothalamic GnRH neurons in an in vitro membrane‐based model	15
Recent research progress of biologically active peptides	15
Interleukin‐5 deletion promotes sepsis‐induced M1 macrophage differentiation, deteriorates cardiac dysfunction, and exacerbates cardiac injury via the NF‐κB p65 pathway in mice	14
Mangiferin and organ fibrosis: A mini review	14
Curcuma longa and curcumin affect respiratory and allergic disorders, experimental and clinical evidence: A comprehensive and updated review	14
BCL‐6 promotes the methylation of miR‐34a by recruiting EZH2 and upregulating CTRP9 to protect ischemic myocardial injury	14
Golgi stress response: A regulatory mechanism of Golgi function	14
Vitamin D and colorectal cancer: Chemopreventive perspectives through the gut microbiota and the immune system	14
Daidzin inhibits hepatocellular carcinoma survival by interfering with the glycolytic/gluconeogenic pathway through downregulation of TPI1	14
Restoration of NRF2 attenuates myocardial ischemia reperfusion injury through mediating microRNA‐29a‐3p/CCNT2 axis	14
Anticancer targets and mechanisms of calycosin to treat nasopharyngeal carcinoma	14
Reactive oxygen species as a double‐edged sword: The role of oxidative enzymes in antitumor therapy	14
Role of luteolin in overcoming Parkinson's disease	14
Ammonia induces autophagy via circ‐IFNLR1/miR‐2188‐5p/RNF182 axis in tracheas of chickens	14
The role of biofactors in the prevention and treatment of age‐related diseases	14
Resolvin D1: A key endogenous inhibitor of neuroinflammation	13
The role of exosomal non‐codingRNAsin aging‐related diseases	13

Oxidized phospholipids and lipoprotein‐associated phospholipase A₂ (Lp‐PLA₂) in atherosclerotic cardiovascular disease: An update	13
Zerumbone, a ginger sesquiterpene, inhibits migration, invasion, and metastatic behavior of human malignant glioblastoma multiforme in vitro	13
Cannabinoids in neuroinflammatory disorders: Focusing on multiple sclerosis, Parkinsons, and Alzheimers diseases	13
Knockdown of lncRNA TUG1 attenuates cerebral ischemia/reperfusion injury through regulating miR‐142‐3p	13
Protective effect of luteolin against chemical and natural toxicants by targeting NF‐κB pathway	13
SEMO‐1, a novel methanethiol oxidase in Caenorhabditis elegans, is a pro‐aging factor conferring selective stress resistance	13
The cardioprotective effects of hydrogen sulfide by targeting endoplasmic reticulum stress and the Nrf2 signaling pathway: A review	13
Systematic and experimental investigations of the anti‐colorectal cancer mediated by genistein	12
Melatonin ameliorates arsenic‐induced cardiotoxicity through the regulation of the Sirt1/Nrf2 pathway in rats	12
Melatonin ameliorates trimethyltin chloride‐induced cardiotoxicity: The role of nuclear xenobiotic metabolism and Keap1‐Nrf2/ARE axis‐mediated pyroptosis	12
Luteolin supplements: All that glitters is not gold	12
Circulating miR‐155, let‐7c, miR‐21, and PTEN levels in differential diagnosis and prognosis of idiopathic granulomatous mastitis and breast cancer	12
LncRNA LOC100507144 acts as a novel regulator of CD44/Nanog/Sox2/miR‐302/miR‐21 axis in colorectal cancer	11
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR‐7/m‐TOR/SREBP1 pathway on prostate cancer	11
Antioxidant and reducing lipid accumulation effects of rutin in Caenorhabditis elegans	11
Isolation and characterization of N‐(2‐Hydroxyethyl)hexadecanamide from Colletotrichum gloeosporioides with apoptosis‐inducing potential in breast cancer cells	11
Altered triglyceride glucose index and fasted serum triglyceride high‐density lipoprotein cholesterol ratio predict incidence of cardiovascular disease in the Mashhad cohort study	11
CDCA7‐regulated inflammatory mechanism through TLR4/NF‐κB signaling pathway in stomach adenocarcinoma	10
Dietary carbohydrates: Pathogenesis and potential therapeutic targets to obesity‐associated metabolic syndrome	10
Vitamin D₃ enhances the effects of omega‐3 oils against metabolic dysfunction‐associated fatty liver disease in rat	10
alpha‐Tocopherol supplementation reduces inflammation and apoptosis in high cholesterol mediated nonalcoholic steatohepatitis	10
miR‐23b/TAB3/NF‐κB/p53 axis is involved in hippocampus injury induced by cerebral ischemia–reperfusion in rats: The protective effect of chlorogenic acid	10
Rapid and simultaneous determination of histidine metabolism intermediates in human and mouse microbiota and biomatrices	9
Osteoglycin silencing exerts inhibitory effects on myocardial fibrosis and epithelial/endothelial‐mesenchymal transformation in a mouse model of myocarditis	9
Reduction of senescence‐associated beta‐galactosidase activity by vitamin E in human fibroblasts depends on subjects’ age and cell passage number	9
Altered type I collagen networking in osteoporotic human femoral head revealed by histomorphometric and Fourier transform infrared imaging correlated analyses	9
Exosome: From leukemia progression to a novel therapeutic approach in leukemia treatment	9
Production, health‐promoting properties and characterization of bioactive peptides from cereal and legume grains	9
Is there an interplay between the SARS‐CoV‐2 spike protein and Platelet‐Activating factor?	9
Inhibition of glioblastoma proliferation, invasion, and migration by Urolithin B through inducing G0/G1 arrest and targeting MMP‐2/‐9 expression and activity	9
Bioactive dietary components—Anti‐obesity effects related to energy metabolism and inflammation	9
Neutrophil to lymphocyte ratio is not related to carotid atherosclerosis progression and cardiovascular events in the primary prevention of cardiovascular disease: Results from the IMPROVE	9
Berberine ameliorates neuronal AD‐like change via activating Pi3k/PGCε pathway	8
Integrated analysis of the prognostic values of RNA‐binding proteins in head and neck squamous cell carcinoma	8
Protein concentrations and activities of fatty acid desaturase and elongase enzymes in liver, brain, testicle, and kidney from mice: Substrate dependency	8
Tangeretin promotes lifespan associated with insulin/insulin‐like growth factor‐1 signaling pathway and heat resistance in Caenorhabditis elegans	8
Novel roles of Tsukushi in signaling pathways and multiple disease processes	8
Crocin attenuates inflammation of lung tissue in ovalbumin‐sensitized mice by altering the expression of endoplasmic reticulum stress markers	8
Molecular basis and therapeutic potential of myostatin on bone formation and metabolism in orthopedic disease	8
New insights into the core Hippo signaling and biological macromolecules interactions in the biology of solid tumors	8
PDIA4, a novel ER stress chaperone, modulates adiponectin expression and inflammation in adipose tissue	8
Biological and pharmacological activities of noscapine: Focusing on its receptors and mechanisms	8
Carboxylative efficacy of trans and cisMK7 and comparison with other vitamin K isomers	8
Redox‐sensitive signaling pathways in renal cell carcinoma	8