OOIR: Observatory of International Research

Papers

(The median citation count of Platelets is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Prostacyclin analogues decrease platelet aggregation but have no effect on thrombin generation, fibrin clot structure, and fibrinolysis in pulmonary arterial hypertension: PAPAYA coagulation	64
Contributing role of mitochondrial energy metabolism on platelet adhesion, activation and thrombus formation under blood flow conditions	36
Predictive performance of different bleeding risk scores in patients with atrial fibrillation and acute coronary syndrome or undergoing percutaneous coronary intervention	31
Enhanced platelet sensitization is accompanied by increased expression of the transporter MRP4 and elevated plasma S1P levels in mild COVID-19 convalescents	30
Platelet-derived microparticles stimulated by anti-β ₂ GPI/β ₂ GPI complexes induce pyroptosis of endothelial cells in antiphospho	28
Development of an automated chemiluminescence enzyme immunoassay for the measurement of soluble C-type lectin-like receptor 2 (sCLEC-2) and molecular forms of sCLEC-2 measured in patient plasma	27
Trends among platelet function, arterial calcium, and vascular function measures	26
The role of miRNAs in regulation of platelet activity and related diseases - a bioinformatic analysis	25
How can we use proteomics to learn more about platelets?	22
Apoptosis is one cause of thrombocytopenia in patients with high-altitude polycythemia	21
Chronic immune thrombocytopenia in a child with X-linked agammaglobulinemia-an uncommon phenotype	20
The natural anticoagulant protein S; hemostatic functions and deficiency	18
Increased circulating platelet-derived extracellular vesicles in severe COVID-19 disease	17
Sex-specific relationship between blood selenium levels and platelet count in a large cohort representative of the United States population	17
Platelets and open access – a new era dawns	16
Clinical features and treatment effect of HIV-associated immune thrombocytopenia—single center Ten-Years data summary	16
Dual antiplatelet therapy is associated with high α-tubulin acetylation in circulating platelets from coronary artery disease patients	16
Pro106Leu MPL mutation is associated with thrombocytosis and a low risk of thrombosis, splenomegaly and marrow fibrosis	16
Association between megakaryocyte abnormalities on bone marrow smear and response to thrombopoietin receptor agonists in adult patients with primary immune thrombocytopenia	15
Extracellular thiol isomerase ERp5 regulates integrin αIIbβ3 activation by inhibition of fibrinogen binding	15
Recombinant human thrombopoietin (rhTPO) of different dosing regimens for refractory/relapsed primary immune thrombocytopenia: a multicenter, randomized controlled trial and pharmacokinetics study	14
Potential mechanisms involved on how systemic IgG antibodies specific to vascular endothelial growth factor (VEGF) and induced by active immunotherapy decrease platelet derived free-VEGF	13
Avatrombopag improves thrombocytopenia in MYH9-related disorder following eltrombopag treatment failure	13
Effects of exercise on platelet reactivity after myocardial infarction: a randomized clinical trial	13
Variation in activation marker expression within the platelet population – a new parameter for evaluation of platelet flow cytometry data	13

Phosphorylation of (Ser 291) in the linker insert of Syk negatively regulates ITAM signaling in platelets	12
European Delphi panel to build consensus on tapering and discontinuing thrombopoietin receptor agonists in immune thrombocytopenia	12
Platelet response to aspirin in UK and Irish pregnancy cohorts: a genome-wide approach	12
Identification of UDP-Glucuronosyltransferase mRNA in human platelets: differential levels in smokers and non-smokers	11
Tirofiban potentiates agonist-induced platelet activation and degranulation, despite effectively inhibiting aggregation	11
Impact of thrombocytopenia-associated c.-118C>T and c.-140C>G ANKRD26 5’UTR variants in three-generational pedigree	11
Apolipoprotein A-I, elevated in trauma patients, inhibits platelet activation and decreases clot strength	11
Recent advances in microfluidic technology of arterial thrombosis investigations	11
Circulating microRNAs as biomarkers and mediators of platelet activation	11
Inflammation modifies the platelet reactivity among thrombocytopenia patients undergoing percutaneous coronary intervention	11
Potential and limitations of PKA/ PKG inhibitors for platelet studies	11
Developmental differences of in vitro cultured murine bone marrow- and fetal liver-derived megakaryocytes	11
Evolution of platelet activation parameters during septic shock in intensive care unit	10
The effect of testosterone on platelet activation and inflammation in transgender men	10
Higher body mass index raises immature platelet count: potential contribution to obesity-related thrombosis	10
Cardiometabolic risk factor burden associates with an immature platelet profile	10
Role of platelet count in a murine stasis model of deep vein thrombosis	10
Neurosurgical bleeding in platelet storage pool disorder: a case report	10
In memory of Dr. Susan S. Smyth, MD/Ph.D.	10
miR-28-5p targeted Rap1b attenuates splenic inflammation infiltration in immune thrombocytopenia	10
A splice mutation in RASGRP2 gene in the patient with recurrent epistaxis and nasal vascular malformation	10
Association of thromboxane generation with the bleeding events in aspirin users	10
Anti-PF4/polyanion antibodies in COVID-19 patients are associated with disease severity and pulmonary pathology	10
Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets	10
Congenital thrombocytopenia associated with a heterozygous variant in the MEIS1 gene encoding a transcription factor essential for megakaryopoiesis	9
Age and outcomes following personalized antiplatelet therapy in chronic coronary syndrome patients: a post hoc analysis of the randomized PATH-PCI trial	9
Early recognition of sepsis-induced coagulopathy using the C2PAC index: a ratio of soluble type C lectin-like receptor 2 (sCLEC-2) level and platelet count	9
Evaluation of human platelet granules by structured illumination laser fluorescence microscopy	9
In vitro evaluation of platelet extracellular vesicles (PEVs) for corneal endothelial regeneration	9
Multiple myeloma and its treatment contribute to increased platelet reactivity	9
Thrombosis and hemorrhage in myeloproliferative neoplasms: The platelet perspective	9
Factors influencing platelet isolation: a prospective multicenter study from Western China	9
Application of the Cellular Thermal Shift Assay (CETSA) to validate drug target engagement in platelets	9
Efficacy and safety of two rituximab biosimilars for treating immune thrombocytopenia: a reference-product matched study	9
Q94 is not a selective modulator of proteinase-activated receptor 1 (PAR1) in platelets	9
The safety and efficacy of indobufen or aspirin combined with clopidogrel in patients with acute myocardial infarction after percutaneous coronary intervention	9
What can we learn from senescent platelets, their transcriptomes and proteomes?	9
Comparison of in-hospital net clinical outcomes of ticagrelor and clopidogrel in acute coronary syndrome patients stratified by CRUSADE score: findings from the CCC-ACS registry	8
Additional efficacy analysis of avatrombopag phase III data for the treatment of adults with immune thrombocytopenia	8
Evaluating stored platelet shape change using imaging flow cytometry	8
Alantolactone induces platelet apoptosis by activating the Akt pathway	8
Appraising non-linear association between pre-diagnostic platelet counts and cancer survival outcomes: observational and genetic analysis	8
Deficiency of BLOS1 moderately impairs the biogenesis of platelet dense granules	8
Platelet-derived respiratory-competent mitochondria transfer to mesenchymal stem cells to promote wound healing via metabolic reprogramming	8
New oral protease-activated receptor 4 antagonist BMS-986120: tolerability, pharmacokinetics, pharmacodynamics, and gene variant effects in humans	8
Association between endometriosis, infertility and autoimmune antiplatelet glycoprotein VI antibodies in two patients	8
Thrombocytopathy vs Platelet hyper-reactivity in COVID-19: diverse pathologies, disease outcomes and therapeutic implications	8
Romiplostim for PARP inhibitor-induced thrombocytopenia in solid tumor malignancies	8
Effect of avatrombopag in the management of severe and refractory chemotherapy-induced thrombocytopenia (CIT) in patients with solid tumors	8
Platelet counts in HFE p.C282Y/p.C282Y and wt/wt post-screening clinical evaluation participants	8

A novel, quantitative clot retraction assay to evaluate platelet function	7
Feasibility of platelet marker analysis in ischemic stroke patients and their association with one-year outcome. A pilot project within a subsample of the Stroke Induced Cardiac Failure in Mice and Me	7
Mapping densely packed αIIbβ3 receptors in murine blood platelets with expansion microscopy	7
Platelet index on admission as a predictor of bacteremia in acute cholangitis: a 7-year retrospective observational study	7
Correction	7
Rapid isolation of mature murine primary megakaryocytes by size exclusion via filtration	7
Cryopreservation affects platelet macromolecular composition over time after thawing and differently impacts on cancer cells behavior in vitro	7
Roles of non-coding RNA in megakaryocytopoiesis and thrombopoiesis: new target therapies in ITP	7
From reticulated platelets to immature platelet fraction: structure, function, and clinical applications	7
Platelet parameters for distinguishing between inherited macrothrombocytopenia and acquired thrombocytopenia: a retrospective case–control study	7
An oligogenic case of severe neonatal thrombocytopenia and a purportedly benign variant in GFI1B requiring reinterpretation	6
Platelet extracellular vesicles are efficient delivery vehicles of doxorubicin, an anti-cancer drug: preparation and in vitro characterization	6
Antiplatelet effects of the CEACAM1-derived peptide QDTT	6
Platelet-HIV: interactions and their implications	6
Introduction of direct-acting antiviral agents alters frequencies of anti-GPIIb/IIIa antibody-producing B cells in chronic hepatitis C patients with thrombocytopenia	6
How can platelet proteomics best be used to interrogate disease?	6
Exacerbation of immune thrombocytopenia following initial and booster vaccination with Pfizer-BioNTech COVID-19 vaccine	6
Role of the NO-GC/cGMP signaling pathway in platelet biomechanics	6
Genetic background of thrombocytosis in mice mimicking hereditary thrombocytosis in humans	6
Mass cytometry of platelet-rich plasma: a new approach to analyze platelet surface expression and reactivity	6
Correlations among different platelet aggregation pathways in a group of healthy volunteers	6
Optimizing the therapeutic window of sirolimus by monitoring blood concentration for the treatment of immune thrombocytopenia	6
Whole blood platelet aggregation measurement by Multiplate™: potential diagnostic inaccuracy of correcting the results for the sample platelet count	6
F11R/JAM-A: why do platelets express a molecule which is also present in tight junctions?	5
Anti-GPIb/IX autoantibodies are associated with poor response to dexamethasone combined with rituximab therapy in primary immune thrombocytopenia patients	5
Platelet-derived extracellular vesicles play an important role in platelet transfusion therapy	5
The complementary roles of VAMP-2, -3, and -7 in platelet secretion and function	5
Immunological platelet transfusion refractoriness: current insights from mechanisms to therapeutics	5
Vaccine-induced immune thrombotic thrombocytopenia in a male after Ad26.COV2.S vaccination presenting as cerebral venous sinus thrombosis	5
A case-control study of bleeding risk in children with 22q11.2 deletion syndrome undergoing cardiac surgery	5
Prevalence and significance of large granular lymphocytes in patients with immune thrombocytopenia	5
A case of acquired transient bleeding diathesis associated with acquired platelet storage pool deficiency and defective thromboxane A2 production	5
Alterations in platelet activity and endothelial glycocalyx biomarkers by treatment with an angiotensin converting enzyme inhibitor or an alpha-1 adrenoceptor antagonist in patients with hypertension:	5
Performance evaluation of PLT-H (hybrid-channel platelet) under various interferences and application studies for platelet transfusion decisions	5
Scanning transmission X-ray microscopy study of subcellular granules in human platelets at the carbon K- and calcium L2,3-edges	5
GALE variants associated with syndromic manifestations, macrothrombocytopenia, bleeding, and platelet dysfunction	5
Effect of iron supplementation on platelet count in adult patients with iron deficiency anemia	5
Megakaryocyte phenotyping in response to SARS-CoV-2 variants	5
Regulation of lipid metabolism: a new strategy for platelet storage	5
Differential effects of dual antiplatelet and dual antithrombotic therapy on hemostasis in chronic coronary syndrome patients: the DEFINE CCS study	5
Platelet-derived extracellular vesicles promote hair follicle growth through β-catenin signaling pathway	5
C-type lectin-like receptor-2 (CLEC-2) is a key regulator of kappa-carrageenan-induced tail thrombosis model in mice	5
Recent advances in understanding spleen tyrosine kinase (SYK) in human biology and disease, with a focus on fostamatinib	5
Successful treatment of acquired amegakaryocytic thrombocytopenia with eltrombopag and immunosuppressant	5
Frequency and molecular basis of CD36 deficiency among platelet donors in Kunming, China	5
Platelet-derived mitochondria transfer facilitates wound-closure by modulating ROS levels in dermal fibroblasts	5
The potential utilization of platelet-derived extracellular vesicles in clinical treatment	5
Decreased platelet miR-199a-5p level might lead to high on-clopidogrel platelet reactivity in patients with coronary artery disease	5
Platelet rich fibrin as a bioactive matrix with proosteogenic and proangiogenic properties on human healthy primary cells in vitro	4
Immune-induced thrombocytopenia by pembrolizumab: case report and review of literature	4
Signaling mechanisms of the platelet glycoprotein Ib-IX complex	4
Recent advances on GPIb-IX-V complex	4
The NLRP3 inflammasome in platelets – form, functions, and future of the complex	4
High fragmentation in platelet concentrates impacts the activation, procoagulant, and aggregatory capacity of platelets	4
Efficacy and safety of high dose recombinant human thrombopoietin in the treatment of immune thrombocytopenia	4
Bleeding and mortality risk in patients implanted with mechanical prosthetic heart valves with and without thrombocytopenia. Insights from the nationwide PLECTRUM registry	4
The CalDAG-GEFI/Rap1/αIIbβ3 axis minimally contributes to accelerated platelet clearance in mice with constitutive store-operated calcium entry	4
Challenges in diagnosing sticky platelet syndrome using light transmission aggregometry: a scoping review	4
Transcriptomic and functional characterization of megakaryocytic-derived platelet-like particles: impaired aggregation and prominent anti-tumor effects	4
The efficacy of platelet rich plasma on women with poor ovarian response: a systematic review and meta-analysis	4
Assessment of whole blood platelet aggregation in patients with cirrhosis: challenges and opportunities	4
Storage of plasma-derived exosomes: evaluation of anticoagulant use and preserving temperatures	4
Exploring the morphine-platelet activity association in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention	4
New presentations and exacerbations of immune thrombocytopenia after coronavirus disease 2019 vaccinations: the Taiwan experience	4
Light transmission aggregometry for platelet function testing: position paper on current recommendations and French proposals for accreditation	4
Method article: anin vitroblood flow model to advance the study of platelet adhesion utilizing a damaged endothelium	4
Eltrombopag modulates the phenotypic evolution and potential immunomodulatory roles of monocytes/macrophages in immune thrombocytopenia	4
Murine models of glycoprotein Ib-IX	4