Platelets

Article	Citations
Contributing role of mitochondrial energy metabolism on platelet adhesion, activation and thrombus formation under blood flow conditions	55
High rate of extreme thrombocytosis indicates bone marrow hyperactivity and splenic dysfunction among congenital diaphragmatic hernia patients	46
Prostacyclin analogues decrease platelet aggregation but have no effect on thrombin generation, fibrin clot structure, and fibrinolysis in pulmonary arterial hypertension: PAPAYA coagulation	35
Predictive performance of different bleeding risk scores in patients with atrial fibrillation and acute coronary syndrome or undergoing percutaneous coronary intervention	33
Platelet-derived microparticles stimulated by anti-β 2 GPI/β 2 GPI complexes induce pyroptosis of endothelial cells in antiphospho	29
Enhanced platelet sensitization is accompanied by increased expression of the transporter MRP4 and elevated plasma S1P levels in mild COVID-19 convalescents	26
Trends among platelet function, arterial calcium, and vascular function measures	26
How can we use proteomics to learn more about platelets?	25
Comparison of predictive value of risk scores for gastrointestinal bleeding in antiplatelet therapy	23
Apoptosis is one cause of thrombocytopenia in patients with high-altitude polycythemia	22
Development of an automated chemiluminescence enzyme immunoassay for the measurement of soluble C-type lectin-like receptor 2 (sCLEC-2) and molecular forms of sCLEC-2 measured in patient plasma	22
Sex-specific relationship between blood selenium levels and platelet count in a large cohort representative of the United States population	21
The role of miRNAs in regulation of platelet activity and related diseases - a bioinformatic analysis	21
Clinical features and treatment effect of HIV-associated immune thrombocytopenia—single center Ten-Years data summary	19
Crushed/chewed administration of potent P2Y12 inhibitors in ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: Systematic review and meta-anal	18
Chronic immune thrombocytopenia in a child with X-linked agammaglobulinemia-an uncommon phenotype	18
Dual antiplatelet therapy is associated with high α-tubulin acetylation in circulating platelets from coronary artery disease patients	17
Platelets and open access – a new era dawns	17
Bioinspired artificial platelets: past, present and future	16
The natural anticoagulant protein S; hemostatic functions and deficiency	16
Increased circulating platelet-derived extracellular vesicles in severe COVID-19 disease	16
Pro106Leu MPL mutation is associated with thrombocytosis and a low risk of thrombosis, splenomegaly and marrow fibrosis	15
Recombinant human thrombopoietin (rhTPO) of different dosing regimens for refractory/relapsed primary immune thrombocytopenia: a multicenter, randomized controlled trial and pharmacokinetics study	15
Effects of exercise on platelet reactivity after myocardial infarction: a randomized clinical trial	15
Association between megakaryocyte abnormalities on bone marrow smear and response to thrombopoietin receptor agonists in adult patients with primary immune thrombocytopenia	15

Pre-operative platelet reactivity is a strong, independent predictor of bleeding complications after branched endovascular thoracoabdominal aortic aneurysm repair	15
Significance of mild thrombocytopenia in maintenance hemodialysis patients; a retrospective cohort study	15
Extracellular thiol isomerase ERp5 regulates integrin αIIbβ3 activation by inhibition of fibrinogen binding	15
Janus kinase inhibitors ruxolitinib and baricitinib impair glycoprotein-VI mediated platelet function	14
Thrombosis in Covid-19 and non-Covid-19 pneumonia: role of platelets	13
Platelet response to aspirin in UK and Irish pregnancy cohorts: a genome-wide approach	13
European Delphi panel to build consensus on tapering and discontinuing thrombopoietin receptor agonists in immune thrombocytopenia	13
Phosphorylation of (Ser 291) in the linker insert of Syk negatively regulates ITAM signaling in platelets	13
Pathogen inactivation of platelets for transfusion	12
Avatrombopag improves thrombocytopenia in MYH9-related disorder following eltrombopag treatment failure	12
Potential mechanisms involved on how systemic IgG antibodies specific to vascular endothelial growth factor (VEGF) and induced by active immunotherapy decrease platelet derived free-VEGF	12
Apolipoprotein A-I, elevated in trauma patients, inhibits platelet activation and decreases clot strength	11
Ion channels and ion homeostasis in the platelet and megakaryocyte	11
Tirofiban potentiates agonist-induced platelet activation and degranulation, despite effectively inhibiting aggregation	11
Variation in activation marker expression within the platelet population – a new parameter for evaluation of platelet flow cytometry data	11
Potential and limitations of PKA/ PKG inhibitors for platelet studies	11
In memory of Dr. Susan S. Smyth, MD/Ph.D.	10
Developmental differences of in vitro cultured murine bone marrow- and fetal liver-derived megakaryocytes	10
Impact of thrombocytopenia-associated c.-118C>T and c.-140C>G ANKRD26 5’UTR variants in three-generational pedigree	10
Association of thromboxane generation with the bleeding events in aspirin users	10
Circulating microRNAs as biomarkers and mediators of platelet activation	10
Inflammation modifies the platelet reactivity among thrombocytopenia patients undergoing percutaneous coronary intervention	10
Recent advances in microfluidic technology of arterial thrombosis investigations	10
Evolution of platelet activation parameters during septic shock in intensive care unit	10
Cardiometabolic risk factor burden associates with an immature platelet profile	9
Higher body mass index raises immature platelet count: potential contribution to obesity-related thrombosis	9
miR-28-5p targeted Rap1b attenuates splenic inflammation infiltration in immune thrombocytopenia	9
Neurosurgical bleeding in platelet storage pool disorder: a case report	9
Frozen and cold-stored platelets: reconsidered platelet products	9
Role of platelet count in a murine stasis model of deep vein thrombosis	9
A splice mutation in RASGRP2 gene in the patient with recurrent epistaxis and nasal vascular malformation	9
Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets	9
Thrombosis and hemorrhage in myeloproliferative neoplasms: The platelet perspective	9
In vitro evaluation of platelet extracellular vesicles (PEVs) for corneal endothelial regeneration	8
Evaluation of human platelet granules by structured illumination laser fluorescence microscopy	8
What can we learn from senescent platelets, their transcriptomes and proteomes?	8
The plant hormone abscisic acid stimulates megakaryocyte differentiation from human iPSCs in vitro	8
EloA promotes HEL polyploidization upon PMA stimulation through enhanced ERK1/2 activity	8
Efficacy and safety of two rituximab biosimilars for treating immune thrombocytopenia: a reference-product matched study	8
Early recognition of sepsis-induced coagulopathy using the C2PAC index: a ratio of soluble type C lectin-like receptor 2 (sCLEC-2) level and platelet count	8
Anti-PF4/polyanion antibodies in COVID-19 patients are associated with disease severity and pulmonary pathology	8
Application of the Cellular Thermal Shift Assay (CETSA) to validate drug target engagement in platelets	8
Platelet-derived respiratory-competent mitochondria transfer to mesenchymal stem cells to promote wound healing via metabolic reprogramming	8
Congenital thrombocytopenia associated with a heterozygous variant in the MEIS1 gene encoding a transcription factor essential for megakaryopoiesis	8
The safety and efficacy of indobufen or aspirin combined with clopidogrel in patients with acute myocardial infarction after percutaneous coronary intervention	8
Factors influencing platelet isolation: a prospective multicenter study from Western China	8
Age and outcomes following personalized antiplatelet therapy in chronic coronary syndrome patients: a post hoc analysis of the randomized PATH-PCI trial	7
Evaluating stored platelet shape change using imaging flow cytometry	7
Roles of non-coding RNA in megakaryocytopoiesis and thrombopoiesis: new target therapies in ITP	7
Alantolactone induces platelet apoptosis by activating the Akt pathway	7

Additional efficacy analysis of avatrombopag phase III data for the treatment of adults with immune thrombocytopenia	7
Thrombocytopathy vs Platelet hyper-reactivity in COVID-19: diverse pathologies, disease outcomes and therapeutic implications	7
Effect of avatrombopag in the management of severe and refractory chemotherapy-induced thrombocytopenia (CIT) in patients with solid tumors	7
Cryopreservation affects platelet macromolecular composition over time after thawing and differently impacts on cancer cells behavior in vitro	7
Q94 is not a selective modulator of proteinase-activated receptor 1 (PAR1) in platelets	7
Multiple myeloma and its treatment contribute to increased platelet reactivity	7
Platelet counts in HFE p.C282Y/p.C282Y and wt/wt post-screening clinical evaluation participants	7
Platelet index on admission as a predictor of bacteremia in acute cholangitis: a 7-year retrospective observational study	7
Positive correlations between plasma BPI level and MPO-DNA and S100A8/A9 in myocardial infarction	6
Alterations in platelets during SARS-CoV-2 infection	6
Mapping densely packed αIIbβ3 receptors in murine blood platelets with expansion microscopy	6
Rapid isolation of mature murine primary megakaryocytes by size exclusion via filtration	6
Genetic background of thrombocytosis in mice mimicking hereditary thrombocytosis in humans	6
Appraising non-linear association between pre-diagnostic platelet counts and cancer survival outcomes: observational and genetic analysis	6
Romiplostim for PARP inhibitor-induced thrombocytopenia in solid tumor malignancies	6
New oral protease-activated receptor 4 antagonist BMS-986120: tolerability, pharmacokinetics, pharmacodynamics, and gene variant effects in humans	6
Platelet parameters for distinguishing between inherited macrothrombocytopenia and acquired thrombocytopenia: a retrospective case–control study	6
Current challenges in platelet transfusion	6
An oligogenic case of severe neonatal thrombocytopenia and a purportedly benign variant in GFI1B requiring reinterpretation	6
Feasibility of platelet marker analysis in ischemic stroke patients and their association with one-year outcome. A pilot project within a subsample of the Stroke Induced Cardiac Failure in Mice and Me	6
Association between endometriosis, infertility and autoimmune antiplatelet glycoprotein VI antibodies in two patients	6
A novel, quantitative clot retraction assay to evaluate platelet function	6
From reticulated platelets to immature platelet fraction: structure, function, and clinical applications	6
Exacerbation of immune thrombocytopenia following initial and booster vaccination with Pfizer-BioNTech COVID-19 vaccine	6
Correction	6
The complementary roles of VAMP-2, -3, and -7 in platelet secretion and function	5
Inhibition of platelet-activating factor (PAF)-induced platelet aggregation by fatty acids from human saliva	5
Introduction of direct-acting antiviral agents alters frequencies of anti-GPIIb/IIIa antibody-producing B cells in chronic hepatitis C patients with thrombocytopenia	5
Optimizing the therapeutic window of sirolimus by monitoring blood concentration for the treatment of immune thrombocytopenia	5
Platelet extracellular vesicles are efficient delivery vehicles of doxorubicin, an anti-cancer drug: preparation and in vitro characterization	5
Platelet-HIV: interactions and their implications	5
GALE variants associated with syndromic manifestations, macrothrombocytopenia, bleeding, and platelet dysfunction	5
Effect of iron supplementation on platelet count in adult patients with iron deficiency anemia	5
Correlations among different platelet aggregation pathways in a group of healthy volunteers	5
Antiplatelet effects of the CEACAM1-derived peptide QDTT	5
How can platelet proteomics best be used to interrogate disease?	5
The potential utilization of platelet-derived extracellular vesicles in clinical treatment	5
Immunological platelet transfusion refractoriness: current insights from mechanisms to therapeutics	5
Neonatal platelet physiology and implications for transfusion	5
Frequency and molecular basis of CD36 deficiency among platelet donors in Kunming, China	5
Whole blood platelet aggregation measurement by Multiplate™: potential diagnostic inaccuracy of correcting the results for the sample platelet count	5
Role of the NO-GC/cGMP signaling pathway in platelet biomechanics	5
Differential effect of clopidogrel and ticagrelor on leukocyte count in relation to patient characteristics, biomarkers and genotype: a PLATO substudy	5
Mass cytometry of platelet-rich plasma: a new approach to analyze platelet surface expression and reactivity	5
Regulation of lipid metabolism: a new strategy for platelet storage	5
Platelet-derived mitochondria transfer facilitates wound-closure by modulating ROS levels in dermal fibroblasts	5
Nebulization with alkaline hipertonic ibuprofen induces a rapid increase in platelets circulating in COVID-19 patients but not in healthy subjects	5
Assessment of whole blood platelet aggregation in patients with cirrhosis: challenges and opportunities	4
The role of viscoelastic testing in assessing peri-interventional platelet function and coagulation	4
Platelet rich fibrin as a bioactive matrix with proosteogenic and proangiogenic properties on human healthy primary cells in vitro	4
Bleeding and mortality risk in patients implanted with mechanical prosthetic heart valves with and without thrombocytopenia. Insights from the nationwide PLECTRUM registry	4
Performance evaluation of PLT-H (hybrid-channel platelet) under various interferences and application studies for platelet transfusion decisions	4
Platelet-derived extracellular vesicles play an important role in platelet transfusion therapy	4
Prevalence and significance of large granular lymphocytes in patients with immune thrombocytopenia	4
Anti-GPIb/IX autoantibodies are associated with poor response to dexamethasone combined with rituximab therapy in primary immune thrombocytopenia patients	4
Platelet-derived extracellular vesicles promote hair follicle growth through β-catenin signaling pathway	4
Efficacy and safety of high dose recombinant human thrombopoietin in the treatment of immune thrombocytopenia	4
Storage of plasma-derived exosomes: evaluation of anticoagulant use and preserving temperatures	4
F11R/JAM-A: why do platelets express a molecule which is also present in tight junctions?	4
Successful treatment of acquired amegakaryocytic thrombocytopenia with eltrombopag and immunosuppressant	4
Recent advances in understanding spleen tyrosine kinase (SYK) in human biology and disease, with a focus on fostamatinib	4
Alterations in platelet activity and endothelial glycocalyx biomarkers by treatment with an angiotensin converting enzyme inhibitor or an alpha-1 adrenoceptor antagonist in patients with hypertension:	4
C-type lectin-like receptor-2 (CLEC-2) is a key regulator of kappa-carrageenan-induced tail thrombosis model in mice	4
A case of acquired transient bleeding diathesis associated with acquired platelet storage pool deficiency and defective thromboxane A2 production	4
Murine models of glycoprotein Ib-IX	4
Determining the optimal storage time and temperature for performing platelet function assays and global hemostasis assays	4
Platelet activation by charged ligands and nanoparticles: platelet glycoprotein receptors as pattern recognition receptors	4
A case-control study of bleeding risk in children with 22q11.2 deletion syndrome undergoing cardiac surgery	4
Vaccine-induced immune thrombotic thrombocytopenia in a male after Ad26.COV2.S vaccination presenting as cerebral venous sinus thrombosis	4
Decreased platelet miR-199a-5p level might lead to high on-clopidogrel platelet reactivity in patients with coronary artery disease	4
Scanning transmission X-ray microscopy study of subcellular granules in human platelets at the carbon K- and calcium L2,3-edges	4
Method article: anin vitroblood flow model to advance the study of platelet adhesion utilizing a damaged endothelium	3
Potential biomarkers for inherited thrombocytopenia 2 identified by plasma proteomics	3
Eltrombopag modulates the phenotypic evolution and potential immunomodulatory roles of monocytes/macrophages in immune thrombocytopenia	3
Finding and following: a deep learning-based pipeline for tracking platelets during thrombus formation in vivo and ex vivo	3
Real-life clinical practice in Spain in the setting of new drug availability for ITP treatment. A Delphi-based Spanish expert panel consensus	3
Relationship between thrombocytopenia and prognosis in children with septic shock: a retrospective cohort study	3
Developing human tissue engineered arterial constructs to simulate human in vivo thrombus formation	3
Glycan-Lectin interactions between platelets and tumor cells drive hematogenous metastasis	3
The CalDAG-GEFI/Rap1/αIIbβ3 axis minimally contributes to accelerated platelet clearance in mice with constitutive store-operated calcium entry	3

Immune-induced thrombocytopenia by pembrolizumab: case report and review of literature	3
Exploring the morphine-platelet activity association in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention	3
Signaling mechanisms of the platelet glycoprotein Ib-IX complex	3
Thrombus remodelling by reversible and irreversible P2Y 12 inhibitors	3
New αIIbβ3 variants in 28 Turkish Glanzmann patients; structural hypothesis for complex activation by residues variations in I-EGF domains	3
Molecular insights on Eltrombopag: potential mitogen stimulants, angiogenesis, and therapeutic radioprotectant through TPO-R activation	3
Immature platelets and cardiovascular events in patients with stable coronary artery disease	3
The efficacy of platelet rich plasma on women with poor ovarian response: a systematic review and meta-analysis	3
Recent advances on GPIb-IX-V complex	3
Light transmission aggregometry for platelet function testing: position paper on current recommendations and French proposals for accreditation	3
“Tailored” antiplatelet bridging therapy with cangrelor: moving toward personalized medicine	3
Transcriptomic and functional characterization of megakaryocytic-derived platelet-like particles: impaired aggregation and prominent anti-tumor effects	3
The phenotype of cryopreserved platelets influences the formation of platelet-leukocyte aggregates in an in vitro model	3
Activation of AMPK in platelets promotes the production of offspring	3
Effect of aspirin dosage on oxidative stress and platelet reactivity in patients undergoing coronary artery bypass grafting (APRICOT): randomized controlled trial	3
Akt pathway activation reduces platelet apoptosis and contributes to the increase of platelet counts in solid tumor patients	3
High fragmentation in platelet concentrates impacts the activation, procoagulant, and aggregatory capacity of platelets	3
New presentations and exacerbations of immune thrombocytopenia after coronavirus disease 2019 vaccinations: the Taiwan experience	3