Platelets

Article	Citations
High rate of extreme thrombocytosis indicates bone marrow hyperactivity and splenic dysfunction among congenital diaphragmatic hernia patients	59
Prostacyclin analogues decrease platelet aggregation but have no effect on thrombin generation, fibrin clot structure, and fibrinolysis in pulmonary arterial hypertension: PAPAYA coagulation	41
Contributing role of mitochondrial energy metabolism on platelet adhesion, activation and thrombus formation under blood flow conditions	34
Predictive performance of different bleeding risk scores in patients with atrial fibrillation and acute coronary syndrome or undergoing percutaneous coronary intervention	30
Platelet-derived microparticles stimulated by anti-β 2 GPI/β 2 GPI complexes induce pyroptosis of endothelial cells in antiphospho	28
Trends among platelet function, arterial calcium, and vascular function measures	26
Development of an automated chemiluminescence enzyme immunoassay for the measurement of soluble C-type lectin-like receptor 2 (sCLEC-2) and molecular forms of sCLEC-2 measured in patient plasma	25
Enhanced platelet sensitization is accompanied by increased expression of the transporter MRP4 and elevated plasma S1P levels in mild COVID-19 convalescents	24
Apoptosis is one cause of thrombocytopenia in patients with high-altitude polycythemia	23
How can we use proteomics to learn more about platelets?	22
The role of miRNAs in regulation of platelet activity and related diseases - a bioinformatic analysis	20
Sex-specific relationship between blood selenium levels and platelet count in a large cohort representative of the United States population	18
Clinical features and treatment effect of HIV-associated immune thrombocytopenia—single center Ten-Years data summary	18
Platelets and open access – a new era dawns	16
Crushed/chewed administration of potent P2Y12 inhibitors in ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: Systematic review and meta-anal	16
Dual antiplatelet therapy is associated with high α-tubulin acetylation in circulating platelets from coronary artery disease patients	15
The natural anticoagulant protein S; hemostatic functions and deficiency	14
Chronic immune thrombocytopenia in a child with X-linked agammaglobulinemia-an uncommon phenotype	14
Increased circulating platelet-derived extracellular vesicles in severe COVID-19 disease	14
Effects of exercise on platelet reactivity after myocardial infarction: a randomized clinical trial	13
Pro106Leu MPL mutation is associated with thrombocytosis and a low risk of thrombosis, splenomegaly and marrow fibrosis	13
Association between megakaryocyte abnormalities on bone marrow smear and response to thrombopoietin receptor agonists in adult patients with primary immune thrombocytopenia	13
Extracellular thiol isomerase ERp5 regulates integrin αIIbβ3 activation by inhibition of fibrinogen binding	13
Tirofiban potentiates agonist-induced platelet activation and degranulation, despite effectively inhibiting aggregation	12
Potential mechanisms involved on how systemic IgG antibodies specific to vascular endothelial growth factor (VEGF) and induced by active immunotherapy decrease platelet derived free-VEGF	12

Significance of mild thrombocytopenia in maintenance hemodialysis patients; a retrospective cohort study	12
Recombinant human thrombopoietin (rhTPO) of different dosing regimens for refractory/relapsed primary immune thrombocytopenia: a multicenter, randomized controlled trial and pharmacokinetics study	12
Avatrombopag improves thrombocytopenia in MYH9-related disorder following eltrombopag treatment failure	11
European Delphi panel to build consensus on tapering and discontinuing thrombopoietin receptor agonists in immune thrombocytopenia	11
Platelet response to aspirin in UK and Irish pregnancy cohorts: a genome-wide approach	11
Apolipoprotein A-I, elevated in trauma patients, inhibits platelet activation and decreases clot strength	11
Variation in activation marker expression within the platelet population – a new parameter for evaluation of platelet flow cytometry data	11
Recent advances in microfluidic technology of arterial thrombosis investigations	10
Inflammation modifies the platelet reactivity among thrombocytopenia patients undergoing percutaneous coronary intervention	10
Potential and limitations of PKA/ PKG inhibitors for platelet studies	10
Phosphorylation of (Ser 291) in the linker insert of Syk negatively regulates ITAM signaling in platelets	10
Developmental differences of in vitro cultured murine bone marrow- and fetal liver-derived megakaryocytes	10
Impact of thrombocytopenia-associated c.-118C>T and c.-140C>G ANKRD26 5’UTR variants in three-generational pedigree	10
Evolution of platelet activation parameters during septic shock in intensive care unit	10
Circulating microRNAs as biomarkers and mediators of platelet activation	10
In memory of Dr. Susan S. Smyth, MD/Ph.D.	9
Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets	9
EloA promotes HEL polyploidization upon PMA stimulation through enhanced ERK1/2 activity	9
Neurosurgical bleeding in platelet storage pool disorder: a case report	9
Identification of UDP-Glucuronosyltransferase mRNA in human platelets: differential levels in smokers and non-smokers	9
A splice mutation in RASGRP2 gene in the patient with recurrent epistaxis and nasal vascular malformation	9
Association of thromboxane generation with the bleeding events in aspirin users	9
Early recognition of sepsis-induced coagulopathy using the C2PAC index: a ratio of soluble type C lectin-like receptor 2 (sCLEC-2) level and platelet count	9
Higher body mass index raises immature platelet count: potential contribution to obesity-related thrombosis	9
Role of platelet count in a murine stasis model of deep vein thrombosis	9
Evaluation of human platelet granules by structured illumination laser fluorescence microscopy	9
Anti-PF4/polyanion antibodies in COVID-19 patients are associated with disease severity and pulmonary pathology	9
Cardiometabolic risk factor burden associates with an immature platelet profile	8
The safety and efficacy of indobufen or aspirin combined with clopidogrel in patients with acute myocardial infarction after percutaneous coronary intervention	8
Efficacy and safety of two rituximab biosimilars for treating immune thrombocytopenia: a reference-product matched study	8
Congenital thrombocytopenia associated with a heterozygous variant in the MEIS1 gene encoding a transcription factor essential for megakaryopoiesis	8
What can we learn from senescent platelets, their transcriptomes and proteomes?	8
miR-28-5p targeted Rap1b attenuates splenic inflammation infiltration in immune thrombocytopenia	8
Thrombosis and hemorrhage in myeloproliferative neoplasms: The platelet perspective	8
Age and outcomes following personalized antiplatelet therapy in chronic coronary syndrome patients: a post hoc analysis of the randomized PATH-PCI trial	8
Application of the Cellular Thermal Shift Assay (CETSA) to validate drug target engagement in platelets	8
Factors influencing platelet isolation: a prospective multicenter study from Western China	8
Platelet-derived respiratory-competent mitochondria transfer to mesenchymal stem cells to promote wound healing via metabolic reprogramming	8
Multiple myeloma and its treatment contribute to increased platelet reactivity	8
Evaluating stored platelet shape change using imaging flow cytometry	7
Platelet index on admission as a predictor of bacteremia in acute cholangitis: a 7-year retrospective observational study	7
Deficiency of BLOS1 moderately impairs the biogenesis of platelet dense granules	7
In vitro evaluation of platelet extracellular vesicles (PEVs) for corneal endothelial regeneration	7
Additional efficacy analysis of avatrombopag phase III data for the treatment of adults with immune thrombocytopenia	7
Effect of avatrombopag in the management of severe and refractory chemotherapy-induced thrombocytopenia (CIT) in patients with solid tumors	7
Q94 is not a selective modulator of proteinase-activated receptor 1 (PAR1) in platelets	7
Romiplostim for PARP inhibitor-induced thrombocytopenia in solid tumor malignancies	7
New oral protease-activated receptor 4 antagonist BMS-986120: tolerability, pharmacokinetics, pharmacodynamics, and gene variant effects in humans	7
Thrombocytopathy vs Platelet hyper-reactivity in COVID-19: diverse pathologies, disease outcomes and therapeutic implications	7
A novel, quantitative clot retraction assay to evaluate platelet function	6

Appraising non-linear association between pre-diagnostic platelet counts and cancer survival outcomes: observational and genetic analysis	6
Rapid isolation of mature murine primary megakaryocytes by size exclusion via filtration	6
An oligogenic case of severe neonatal thrombocytopenia and a purportedly benign variant in GFI1B requiring reinterpretation	6
Cryopreservation affects platelet macromolecular composition over time after thawing and differently impacts on cancer cells behavior in vitro	6
Introduction of direct-acting antiviral agents alters frequencies of anti-GPIIb/IIIa antibody-producing B cells in chronic hepatitis C patients with thrombocytopenia	6
Correction	6
From reticulated platelets to immature platelet fraction: structure, function, and clinical applications	6
Exacerbation of immune thrombocytopenia following initial and booster vaccination with Pfizer-BioNTech COVID-19 vaccine	6
Feasibility of platelet marker analysis in ischemic stroke patients and their association with one-year outcome. A pilot project within a subsample of the Stroke Induced Cardiac Failure in Mice and Me	6
Optimizing the therapeutic window of sirolimus by monitoring blood concentration for the treatment of immune thrombocytopenia	6
Platelet counts in HFE p.C282Y/p.C282Y and wt/wt post-screening clinical evaluation participants	6
Mapping densely packed αIIbβ3 receptors in murine blood platelets with expansion microscopy	6
Roles of non-coding RNA in megakaryocytopoiesis and thrombopoiesis: new target therapies in ITP	6
Platelet parameters for distinguishing between inherited macrothrombocytopenia and acquired thrombocytopenia: a retrospective case–control study	6
Platelet-HIV: interactions and their implications	6
Alantolactone induces platelet apoptosis by activating the Akt pathway	6
Antiplatelet effects of the CEACAM1-derived peptide QDTT	6
Association between endometriosis, infertility and autoimmune antiplatelet glycoprotein VI antibodies in two patients	6
GALE variants associated with syndromic manifestations, macrothrombocytopenia, bleeding, and platelet dysfunction	5
Correlations among different platelet aggregation pathways in a group of healthy volunteers	5
Mass cytometry of platelet-rich plasma: a new approach to analyze platelet surface expression and reactivity	5
Frequency and molecular basis of CD36 deficiency among platelet donors in Kunming, China	5
Megakaryocyte phenotyping in response to SARS-CoV-2 variants	5
The potential utilization of platelet-derived extracellular vesicles in clinical treatment	5
Vaccine-induced immune thrombotic thrombocytopenia in a male after Ad26.COV2.S vaccination presenting as cerebral venous sinus thrombosis	5
Genetic background of thrombocytosis in mice mimicking hereditary thrombocytosis in humans	5
Whole blood platelet aggregation measurement by Multiplate™: potential diagnostic inaccuracy of correcting the results for the sample platelet count	5
Platelet extracellular vesicles are efficient delivery vehicles of doxorubicin, an anti-cancer drug: preparation and in vitro characterization	5
The complementary roles of VAMP-2, -3, and -7 in platelet secretion and function	5
Effect of iron supplementation on platelet count in adult patients with iron deficiency anemia	5
Performance evaluation of PLT-H (hybrid-channel platelet) under various interferences and application studies for platelet transfusion decisions	5
Role of the NO-GC/cGMP signaling pathway in platelet biomechanics	5
How can platelet proteomics best be used to interrogate disease?	5
Platelet-derived mitochondria transfer facilitates wound-closure by modulating ROS levels in dermal fibroblasts	5
Immunological platelet transfusion refractoriness: current insights from mechanisms to therapeutics	5
Regulation of lipid metabolism: a new strategy for platelet storage	5
Scanning transmission X-ray microscopy study of subcellular granules in human platelets at the carbon K- and calcium L2,3-edges	5
Murine models of glycoprotein Ib-IX	4
F11R/JAM-A: why do platelets express a molecule which is also present in tight junctions?	4
Prevalence and significance of large granular lymphocytes in patients with immune thrombocytopenia	4
A case-control study of bleeding risk in children with 22q11.2 deletion syndrome undergoing cardiac surgery	4
C-type lectin-like receptor-2 (CLEC-2) is a key regulator of kappa-carrageenan-induced tail thrombosis model in mice	4
Efficacy and safety of high dose recombinant human thrombopoietin in the treatment of immune thrombocytopenia	4
Recent advances on GPIb-IX-V complex	4
Exploring the morphine-platelet activity association in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention	4
Differential effects of dual antiplatelet and dual antithrombotic therapy on hemostasis in chronic coronary syndrome patients: the DEFINE CCS study	4
Platelet-derived extracellular vesicles play an important role in platelet transfusion therapy	4
Alterations in platelet activity and endothelial glycocalyx biomarkers by treatment with an angiotensin converting enzyme inhibitor or an alpha-1 adrenoceptor antagonist in patients with hypertension:	4
Decreased platelet miR-199a-5p level might lead to high on-clopidogrel platelet reactivity in patients with coronary artery disease	4
Anti-GPIb/IX autoantibodies are associated with poor response to dexamethasone combined with rituximab therapy in primary immune thrombocytopenia patients	4
The CalDAG-GEFI/Rap1/αIIbβ3 axis minimally contributes to accelerated platelet clearance in mice with constitutive store-operated calcium entry	4
New presentations and exacerbations of immune thrombocytopenia after coronavirus disease 2019 vaccinations: the Taiwan experience	4
Platelet rich fibrin as a bioactive matrix with proosteogenic and proangiogenic properties on human healthy primary cells in vitro	4
Storage of plasma-derived exosomes: evaluation of anticoagulant use and preserving temperatures	4
Recent advances in understanding spleen tyrosine kinase (SYK) in human biology and disease, with a focus on fostamatinib	4
Successful treatment of acquired amegakaryocytic thrombocytopenia with eltrombopag and immunosuppressant	4
A case of acquired transient bleeding diathesis associated with acquired platelet storage pool deficiency and defective thromboxane A2 production	4
Platelet-derived extracellular vesicles promote hair follicle growth through β-catenin signaling pathway	4
Light transmission aggregometry for platelet function testing: position paper on current recommendations and French proposals for accreditation	4
Bleeding and mortality risk in patients implanted with mechanical prosthetic heart valves with and without thrombocytopenia. Insights from the nationwide PLECTRUM registry	4
Glycan-Lectin interactions between platelets and tumor cells drive hematogenous metastasis	3
Proteomics-wise, how similar are mouse and human platelets?	3
Finding and following: a deep learning-based pipeline for tracking platelets during thrombus formation in vivo and ex vivo	3
The phenotype of cryopreserved platelets influences the formation of platelet-leukocyte aggregates in an in vitro model	3
Eltrombopag modulates the phenotypic evolution and potential immunomodulatory roles of monocytes/macrophages in immune thrombocytopenia	3
Immune-induced thrombocytopenia by pembrolizumab: case report and review of literature	3
High fragmentation in platelet concentrates impacts the activation, procoagulant, and aggregatory capacity of platelets	3
Transcriptomic and functional characterization of megakaryocytic-derived platelet-like particles: impaired aggregation and prominent anti-tumor effects	3
First-in-human study to assess the safety, pharmacokinetics, and pharmacodynamics of BMS-986141, a novel, reversible, small-molecule, PAR4 agonist in non-Japanese and Japanese healthy participants	3
Effect of aspirin dosage on oxidative stress and platelet reactivity in patients undergoing coronary artery bypass grafting (APRICOT): randomized controlled trial	3
Developing human tissue engineered arterial constructs to simulate human in vivo thrombus formation	3
Relationship between thrombocytopenia and prognosis in children with septic shock: a retrospective cohort study	3
Method article: anin vitroblood flow model to advance the study of platelet adhesion utilizing a damaged endothelium	3
Signaling mechanisms of the platelet glycoprotein Ib-IX complex	3
Thrombus remodelling by reversible and irreversible P2Y 12 inhibitors	3
Akt pathway activation reduces platelet apoptosis and contributes to the increase of platelet counts in solid tumor patients	3
Activation of AMPK in platelets promotes the production of offspring	3
Immature platelets and cardiovascular events in patients with stable coronary artery disease	3
The efficacy of platelet rich plasma on women with poor ovarian response: a systematic review and meta-analysis	3
“Tailored” antiplatelet bridging therapy with cangrelor: moving toward personalized medicine	3

Assessment of whole blood platelet aggregation in patients with cirrhosis: challenges and opportunities

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