OOIR: Observatory of International Research

Papers

(The H4-Index of Current Opinion in Biotechnology is 50. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Deep learning for optimization of protein expression	271
Recent progress in the synthesis of advanced biofuel and bioproducts	213
Inhalable mRNA vaccines for respiratory diseases: a roadmap	173
Enhancing phage therapy through synthetic biology and genome engineering	151
Beyond vancomycin: recent advances in the modification, reengineering, production and discovery of improved glycopeptide antibiotics to tackle multidrug-resistant bacteria	114
Microenvironmental effects can masquerade as substrate channelling in cascade biocatalysis	112
Optimizing the value of bioinks and robotics to advance in vivo bioprinting	103
Editorial Reflections on BioEnergy: Perspectives from 2024	102
The yin and yang of itaconate metabolism and its impact on the tumor microenvironment	101
Avoidance of detrimental defense responses in beneficial plant–microbe interactions	96
Editorial overview: Biotechnology to help understand and harness biotic interactions in plants	92
Novel transducers for high-channel-count neuroelectronic recording interfaces	92
Bioelectrosynthesis systems	91
Editorial Board	90
Editorial Board	83
Editorial overview: Tissue, cell, and pathway engineering: Recent innovations in biomedical technologies	81
Autophagy as a critical driver of metabolic adaptation, therapeutic resistance, and immune evasion of cancer	80
Tumor lipid metabolism: a mechanistic link between diet and cancer progression	79
Systems biology-based analysis of cell-free systems	75
Recent advances of machine learning applications in human gut microbiota study: from observational analysis toward causal inference and clinical intervention	75
Editorial overview: Analytical biotechnology for healthcare, strain engineering, biosensing and synthetic biology	75
Editorial Board	75
Recent advances in microbial community analysis from machine learning of multiparametric flow cytometry data	74
Editorial Board	73
Integrative metabolic flux analysis reveals an indispensable dimension of phenotypes	72

Biotechnological interventions in reducing losses of tropical fruits and vegetables	72
Isotope tracing in health and disease	71
Adaptive biomimicry: design of neural interfaces with enhanced biointegration	71
Recent advances in bivalve-microbiota interactions for disease prevention in aquaculture	69
Editorial overview: Unlocking the secrets of nongenetic plasticity, one cell at a time	67
Stem cell engineering approaches for investigating glial cues in central nervous system disorders	67
Biological recognition and cellular trafficking of targeted RNA-lipid nanoparticles	64
The osteo-angiogenic signaling crosstalk for bone regeneration: harmony out of complexity	61
Coral holobionts and biotechnology: from Blue Economy to coral reef conservation	60
Application of bacteriophage-derived endolysins to combat streptococcal disease: current state and perspectives	59
Biotechnology approaches for natural product discovery, engineering, and production based on Burkholderia bacteria	58
Constructing next-generation CRISPR–Cas tools from structural blueprints	58
The dawn of interoperating spatial models in cell biology	58
Progress toward rapid, at-line N-glycosylation detection and control for recombinant protein expression	57
Toward optimal use of biomass as carbon source for chemical bioproduction	57
Harnessing the omics revolution to address the global biodiversity crisis	57
Bio-based antimicrobial compositions and sensing technologies to improve food safety	57
Microbial single-cell mass spectrometry: status, challenges, and prospects	55
Engineering protein nanoparticles for drug delivery	55
Bridging the gender gap in autoimmunity with T-cell–targeted biomaterials	53
Mineralized collagen scaffolds for regenerative engineering applications	52
Coupling and uncoupling growth and product formation for producing chemicals	51
The prospect of superior yeast for winemaking: recent successes through bioprospecting	50
Jump-starting chimeric antigen receptor-T cells to go the extra mile with nanotechnology	50
Methane to bioproducts: unraveling the potential of methanotrophs for biomanufacturing	50