Current Opinion in Genetics & Development

Article	Citations
Editorial Board	60
Editorial Board	55
Integrative approaches to study enhancer–promoter communication	51
Editorial overview: Conflicts, conflicts everywhere	50
Editorial Board	49
Why is measuring and predicting fitness under genomic conflict so hard?	44
Evolution and ecology of commensal gut protists: recent advances	41
A critical role for X-chromosome architecture in mammalian X-chromosome dosage compensation	39
Tile by tile: capturing the evolutionary mosaic of human conditions	38
Epithelial–immune crosstalk in health and disease	37
Adipose tissue endothelial cells: insights into their heterogeneity and functional diversity	36
The X chromosome in C. elegans sex determination and dosage compensation	34
Loops, crosstalk, and compartmentalization: it takes many layers to regulate DNA methylation	33
R-loops in neurodegeneration	31
Editorial Board	30
Therapeutic strategies to target the epitranscriptomic machinery	29
Control of cell fate upon transcription factor–driven cardiac reprogramming	28
Exploring the origin of the development: totipotent stem cells	28
Genetic clues to reprogramming power and formation of mouse oocyte	28
In vitro models of pre- and post-gastrulation embryonic development	28
Mitochondrial metabolism and the continuing search for ultimate regulators of developmental rate	28
High-throughput approaches to functional characterization of genetic variation in yeast	27
Interplay between N-adenosine RNA methylation and mRNA splicing	27
NAT10 and cytidine acetylation in mRNA: intersecting paths in development and disease	27
Toward the dissection of hematopoietic stem cell fates and their determinants	27

Single-cell genomic profiling to study regeneration	25
Using human pluripotent stem cells to dissect trophoblast development	25
Cell–cell interactions between transplanted retinal organoid cells and recipient tissues	23
Genetic disruption of nonsense-mediated mRNA decay in neurodevelopmental disorders	23
If you please, draw me a neuron — linking evolutionary tinkering with human neuron evolution	23
Better together: how cooperativity influences transcriptional bursting	23
Transposon waves at the water-to-land transition	22
Genome instability in mammalian embryos implications for genome editing, development, and evolution	22
Molecular genetics of pulmonary hypertension in children	22
Behavioral evolution by diverging cell type composition	22
Structural variation in humans and our primate kin in the era of telomere-to-telomere genomes and pangenomics	21
Stem-cell-based human and mouse embryo models	21
Timers, variability, and body-wide coordination: C. elegans as a model system for whole-animal developmental timing	21
Dynamic microenvironments shape nuclear organization and gene expression	21
Adipose tissue-derived lipokines in metabolism	21
Editorial overview: Drivers, droplets, and deeds of nuclear genome organization	20
The Yin and Yang of replicative aging and rejuvenation	20
Nuclear remodeling during cell fate transitions	19
Enhancers on the edge — how the nuclear envelope controls gene regulatory elements	19
A haystack in the needle: packaging sperm DNA in insects	19
Editorial Board	19
Modifying gastruloids to dissect mechanisms of tissue-specific induction	18
Editorial overview: Multiscale regulation of genome folding in space, time, and across the tree of life	18
Recipes and ingredients for deep learning models of 3D genome folding	17
Human 8-cell embryo-like cells from pluripotent stem cells	17
Multi-organelle-mediated mRNA localization in neurons and links to disease	17
Intestinal epithelial organoids: regeneration and maintenance of the intestinal epithelium	16
Evolution of 3D chromatin organization at different scales	16
What are tethering elements?	16
Nucleosomes in mammalian sperm: conveying paternal epigenetic inheritance or subject to reprogramming between generations?	16
Linking phenotype to genotype using comprehensive genomic comparisons	16
Shaping inheritance: how distinct reproductive strategies influence DNA methylation memory in plants	16
Epigenetic priming in the male germline	16
Digesting the mechanobiology of the intestinal epithelium	16
Meiotic drive of noncentromeric loci in mammalian meiosis II eggs	16
Editorial overview: Peering into our history through a genetic lens: How advances in genetics are changing our understanding of human evolution	16
Editorial Board	15
Biological roles of nonsense-mediated RNA decay: insights from the nervous system	15
Maternal genetic factors in the development of congenital heart defects	15
Advances in skeletal genomics research across tissues and cells	15
Editorial overview: Epigenetic inheritance: A shortcut to environmental adaptation?	15
Rewiring cancer: 3D genome determinants of cancer hallmarks	15
Transposable elements in early human embryo development and embryo models	14
Cell identity conversion in liver regeneration after injury	14
Editorial Board	14
Cellular plasticity in the neural crest and cancer	14
Deciphering microglia phenotypes in health and disease	14
Inheritance of epigenetic transcriptional memory	14
Songbird germline-restricted chromosome as a potential arena of genetic conflicts	14
Correlation between protein abundance and sequence conservation: what do recent experiments say?	14

Architecture of RNA–RNA interactions	14
Cancer-associated chromatin variants uncover the oncogenic role of transposable elements	14
Approaches to probe and perturb long noncoding RNA functions in diseases	14
Editorial overview: Epitranscriptomics: Exploring a new frontier in health and disease	14
Alterations in transcriptional networks in cancer: the role of noncoding somatic driver mutations	14
Editorial overview: Regaining architecture and cell cross-talk upon regeneration	14
Recent developments in adipose tissue-secreted factors and their target organs	13
Editorial overview: The genome in space–time	13
Mix-and-match between transposable elements and zinc finger proteins fuels genic and regulatory innovation	13
Toward a comprehensive view of gene architecture during transcription	13
Challenges and potential solutions for studying the genetic and phenotypic architecture of adaptation in microbes	13
Principles of genome activation in the early embryo	13
Amending the injured heart by in vivo reprogramming	13
Adipose tissue lipid metabolism: lipolysis	13
The stem cell zoo for comparative studies of developmental tempo	13
Brain organoids: the quest to decipher human-specific features of brain development	13
A new era of understanding in vivo metabolic flux in thermogenic adipocytes	13
Evolutionary genetics meets ecological immunology: insights into the evolution of immune systems	13
Evolution and molecular bases of reproductive isolation	13
Oncogenic fusion proteins and their role in three-dimensional chromatin structure, phase separation, and cancer	12
Editorial Board	12
In vitro models of human hypoblast and mouse primitive endoderm	12
The role of loop extrusion in enhancer-mediated gene activation	12
Evolution of comparative transcriptomics: biological scales, phylogenetic spans, and modeling frameworks	12
3D chromosomal architecture in germinal center B cells and its alterations in lymphomagenesis	12
Exploring conditional gene essentiality through systems genetics approaches in yeast	12
Microbial experimental evolution in a massively multiplexed and high-throughput era	12
Bridging spatial and temporal scales of developmental gene regulation	12
Dissecting nephron morphogenesis using kidney organoids from human pluripotent stem cells	12
Phase separation and inheritance of repressive chromatin domains	12
Genome folding dynamics during the M-to-G1-phase transition	12
Alternative splicing in addiction	12
The role of SAF-A/hnRNP U in regulating chromatin structure	11
The role of tissue maturity and mechanical state in controlling cell extrusion	11
Epistasis and evolutionary dependencies in human cancers	11
Reconstitution of reproductive organ system that produces functional oocytes	11
Polycomb complexes in MLL–AF9-related leukemias	11
Paternal genome elimination: patterns and mechanisms of drive and silencing	11
Proliferation and dissemination of killer meiotic drive loci	11
Topical section: embryonic models (2023) for Current Opinion in Genetics & Development	11
Editorial Board	11
Editorial Overview: Developmental mechanisms patterning and evolution (2025)	11
Chromosome organization in 4D: insights from C. elegans development	11
When 3D genome changes cause disease: the impact of structural variations in congenital disease and cancer	11
In search of conserved principles of planar cell polarization	11
Editorial Board	11
Prospects for precision genetic medicine in congenital heart disease	10
Cellular diversity and developmental hierarchy in the planarian nervous system	10
The genetic landscape of cardiovascular left–right patterning defects	10
Recent advances in stem cell-based blastocyst models	10
Transposon persistence and control in germ cells	10
Jack of all trades versus master of one: how generalist versus specialist strategies of transposable elements relate to their horizontal transfer between lineages	10
The metabolic baton: conducting the dance of N6-methyladenosine writing and erasing	10
Timing mechanisms: insights from comparative neural differentiation systems	10
Can we stop one heart from breaking: triumphs and challenges in cardiac reprogramming	10
The power of proximity: mechanisms and biological roles of transvection	10
Principles of long-range gene regulation	9
R-loop homeostasis in genome dynamics, gene expression and development	9
Ex situ-armus: experimental models for combating respiratory dysfunction	9
Decoding N6-methyladenosine’s dynamic role in stem cell fate and early embryo development: insights into RNA–chromatin interactions	9
Hijacked enhancer–promoter and silencer–promoter loops in cancer	9
Editorial Board	9
To splice or not to splice: pseudoexons in neurological disease and opportunities for intervention	9
Quantitative mapping of the mammalian epitranscriptome	9
Spliceosome complex and neurodevelopmental disorders	9
Unlocking regeneration: how partial reprogramming resembles tissue healing	9
Clinical Perspectives in Epitranscriptomics	9
Do sex-linked male meiotic drivers contribute to intrinsic hybrid incompatibilities? Recent empirical studies from flies and rodents	8
Pediatric CNS cancer genomics and immunogenomics	8
Temporal patterning of the vertebrate developing neural tube	8
Chromosomal instability as a source of genomic plasticity	8
Editorial Board	8
Xenotransplantation — a shortcut to construct tissue complexity in organoids	8
Experimental evolution of drug resistance in human fungal pathogens	8
Mitochondrial curation for the next generation	8
Corneal regeneration: insights in epithelial stem cell heterogeneity and dynamics	8
The ribonucleoprotein network of the nucleus: a historical perspective	8
Modification of the RNA methylome in neurodevelopmental disorders	8
Epigenetic dynamics during germline development: insights from Drosophila and C. elegans	8
Recent insights into the in vitro culture systems for mammalian embryos	8

Female meiotic drive in plants: mechanisms and dynamics	8
Overcoming muscle stem cell aging	8
Recent insights into the evolution of mutation rates in yeast	7
Mechanisms of regulatory evolution in yeast	7
Network models of chromatin structure	7
Advancements in inner ear development, regeneration, and repair through otic organoids	7
Vascular and immune interactions in islets transplantation and 3D islet models	7
Narrative engineering of the liver	7
The ever-growing world of gastruloids: autogenous models of mammalian embryogenesis	7
Epistatic drift in protein evolution	7
Interplay of transposable elements and ageing: epigenetic regulation and potential epitranscriptomic influence	7
Editorial overview: 3Rs update: a new era in cellular identity and therapeutic plasticity	7
Therapeutic index of targeting select chromatin complexes in human cancer patients	7
Circuit integration by transplanted human neurons	7
Transgenerational epigenetic control of constitutive heterochromatin, transposons, and centromeres	7
A new era in neuromuscular junction research: current advances in self-organized and assembled in vitro models	7
Extending the spectrum in aortopathy: stenosis to aneurysm	7
Evolutionary neurogenomics at single-cell resolution	7
Pluripotent stem cell–derived mesenchymal stem cells for therapeutic applications, developmental study, and cancer research	7
Insights into multilevel spatial regulation within the root stem cell niche	7
Factors that determine cell type–specific CTCF binding in health and disease	7
Linking mitochondria metabolism, developmental timing, and human brain evolution	7
NOVA1/2 genes and alternative splicing in neurodevelopment	7
When and why are mitochondria paternally inherited?	7
Rewiring for movements in meiotic prophase: regulators, roles, and evolutionary pathways	6
Decoding the role of tRNA modifications in cancer progression	6
Somatic mutation burden in relation to aging and functional life span: implications for cellular reprogramming and rejuvenation	6
Plasticity of muscle stem cells in homeostasis and aging	6
Adipocyte plasticity in tissue regeneration, repair, and disease	6
Early central nervous system development and neuron regeneration	6
New methodological approaches and insights gained toward understanding the evolved human skeleton	6
Editorial overview: Early embryonic development models: back to the beginning	6
Genomic snowflakes: how the uniqueness of DNA folding allows us to smell the chemical universe	6
Editorial Board	6
Molecular mechanisms of the specialization of human synapses in the neocortex	6
Concepts, mechanisms and implications of long-term epigenetic inheritance	6
Deciphering the role of structural variation in human evolution: a functional perspective	6
Human trophoblast stem cell-state acquisition from pluripotent stem cells and somatic cells	6
Rethinking chromatin accessibility: from compaction to dynamic interactions	6
Safeguarding the epigenome through the cell cycle: a multitasking game	6
How our brains are built: emerging approaches to understand human-specific features	6
A lifelong duty: how Xist maintains the inactive X chromosome	6
Spatial orchestration of the genome: topological reorganisation during X-chromosome inactivation	6
Engineering immune organoids to regenerate host immune system	6