Current Opinion in Genetics & Development

Article	Citations
Enhancer-promoter communication: hubs or loops?	94
Spatially resolved transcriptomics and its applications in cancer	62
To loop or not to loop: what is the role of TADs in enhancer function and gene regulation?	50
Role of VPS13, a protein with similarity to ATG2, in physiology and disease	49
Evolution of sexual development and sexual dimorphism in insects	47
16p11.2 deletion syndrome	44
Diverse lncRNA mechanisms in brain development and disease	44
Single-molecule tracking of transcription protein dynamics in living cells: seeing is believing, but what are we seeing?	43
Copy number variation and neuropsychiatric illness	42
Evolution of the mutation rate across primates	41
Regulation of 3D chromatin organization by CTCF	40
Advances in colon cancer research: in vitro and animal models	37
Microexons: at the nexus of nervous system development, behaviour and autism spectrum disorder	36
Evolution of pigment cells and patterns: recent insights from teleost fishes	36
4D nucleome modeling	35
Structure-forming repeats and their impact on genome stability	33
The evolution of structural colour in butterflies	32
Nuclear mechanisms of gene expression control: pre-mRNA splicing as a life or death decision	31
Microglial ontogeny, diversity and neurodevelopmental functions	31
The evolution of the human brain and disease susceptibility	31
Epigenetic regulation of mouse preimplantation embryo development	31
The role of clustered protocadherins in neurodevelopment and neuropsychiatric diseases	30
African population history: an ancient DNA perspective	30
Advances in repeat expansion diseases and a new concept of repeat motif–phenotype correlation	30
Extrachromosomal DNA (ecDNA) in cancer pathogenesis	29

An extending ATR–CHK1 circuitry: the replication stress response and beyond	28
Diagnostic genetic testing for neurodevelopmental psychiatric disorders: closing the gap between recommendation and clinical implementation	28
New gene discoveries highlight functional convergence in autism and related neurodevelopmental disorders	28
Poison exons in neurodevelopment and disease	27
Rising from the ashes: cellular senescence in regeneration	27
Generations of genomes: advances in paleogenomics technology and engagement for Indigenous people of the Americas	27
The shifting shape of genomes: dynamics of heterochromatin interactions at the nuclear lamina	26
A cell in hand is worth two in the embryo: recent advances in 2-cell like cell reprogramming	26
The nuclear pore complex and the genome: organizing and regulatory principles	26
Break-induced replication mechanisms in yeast and mammals	26
Activity regulates brain development in the fly	25
Exosomes in cancer development	25
Inferring evolutionary dynamics of mutation rates through the lens of mutation spectrum variation	25
The transcription factor code in iPSC reprogramming	25
DNA end resection during homologous recombination	24
Disentangling the paradox of the PCDH19 clustering epilepsy, a disorder of cellular mosaics	24
Experimental embryology of gastrulation: pluripotent stem cells as a new model system	23
Cortico-basal ganglia circuits underlying dysfunctional control of motor behaviors in neuropsychiatric disorders	23
LINC complex regulation of genome organization and function	22
Active nematics across scales from cytoskeleton organization to tissue morphogenesis	22
Waiting on the Fringe: cell autonomy and signaling delays in segmentation clocks	22
Mechanisms of maternal intergenerational epigenetic inheritance	22
Human adaptation over the past 40,000 years	21
H3–H4 histone chaperones and cancer	21
The mouse alpha-globin cluster: a paradigm for studying genome regulation and organization	21
The role of somatic mosaicism in brain disease	20
Insights into clonal hematopoiesis and its relation to cancer risk	20
Genetic pathways involved in human speech disorders	20
Digesting the mechanobiology of the intestinal epithelium	20
Control of cell shape during epithelial morphogenesis: recent advances	20
Evo-devo of shell colour in gastropods and bivalves	20
Engineering and modeling of multicellular morphologies and patterns	20
The dawn of non-human primate models for neurodevelopmental disorders	20
Molecular mechanisms for targeted ASD treatments	19
RAD51 paralog function in replicative DNA damage and tolerance	19
Xeno-organ donor pigs with multiple genetic modifications – the more the better?	19
Replication stress: from chromatin to immunity and beyond	19
Serine ADP-ribosylation in DNA-damage response regulation	19
The stochastic nature of genome organization and function	19
Mitotic recombination in yeast: what we know and what we don’t know	19
Update on Müller glia regenerative potential for retinal repair	19
The dynamics of chromatin architecture in brain development and function	18
Olfactory receptor choice: a case study for gene regulation in a multi-enhancer system	18
The evolution of post-translational modifications	18
Distinct fibroblasts in scars and regeneration	18
Human evolutionary history in Eastern Eurasia using insights from ancient DNA	18
Prime time for primate functional genomics	18
The role of loop extrusion in enhancer-mediated gene activation	17
Stabilizing hematopoietic stem cells in vitro	17
Linking genotype, cell behavior, and phenotype: multidisciplinary perspectives with a basis in zebrafish patterns	17

Recent insights into zebrafish cardiac regeneration	17
Homologous recombination within repetitive DNA	17
Latest trends in archaeogenetic research of west Eurasians	16
Somatic variants in epilepsy – advancing gene discovery and disease mechanisms	16
Collective effects in epithelial cell death and cell extrusion	16
Recombination and restart at blocked replication forks	16
The WRN helicase: resolving a new target in microsatellite unstable cancers	16
Cellular and developmental basis of avian structural coloration	16
Pigmentation and color pattern diversity in Odonata	16
The role of SAF-A/hnRNP U in regulating chromatin structure	16
Noncanonical imprinting: intergenerational epigenetic inheritance mediated by Polycomb complexes	16
ERK signaling dynamics in the morphogenesis and homeostasis of Drosophila	16
How gene duplication diversifies the landscape of protein oligomeric state and function	16
Regeneration in the spiny mouse, Acomys, a new mammalian model	16
The use of CRISPR/Cas9-based gene editing strategies to explore cancer gene function in mice	16
Structural and functional brain alterations revealed by neuroimaging in CNV carriers	16
Multi-scale dynamics of heterochromatin repair	15
Chromosomal instability as a source of genomic plasticity	15
Mechanical induction and competence in epithelial morphogenesis	15
What a finding of gene copy number variation can add to the diagnosis of developmental neuropsychiatric disorders	15
All for one and one for all: heterogeneity of genetic etiologies in neurodevelopmental psychiatric disorders	14
Histone isoforms and the oncohistone code	14
Metal ion availability and homeostasis as drivers of metabolic evolution and enzyme function	14
The X chromosome in C. elegans sex determination and dosage compensation	14
Homologous recombination deficiency: how genomic signatures are generated	13
A lifelong duty: how Xist maintains the inactive X chromosome	13
Challenges of diagnostic genomics in Latin America	13
Evolution of 3D chromatin organization at different scales	13
Seasonal plasticity: how do butterfly wing pattern traits evolve environmental responsiveness?	13
7q11.23 deletion and duplication	13
What crustaceans can tell us about the evolution of insect wings and other morphologically novel structures	13
Stem-cell-based human and mouse embryo models	13
Vertebrate brain regeneration – a community effort of fate-restricted precursor cell types	12
Reprogramming cellular identity during intestinal regeneration	12
The origins of cancer cell dormancy	12
Eco-evo-devo advances with butterfly eyespots	12
Molecular genetic mechanisms of congenital heart disease	12
Recombination-mediated genome rearrangements	12
Clinical evaluation of patients with a neuropsychiatric risk copy number variant	12
Cell competition in vertebrates — a key machinery for tissue homeostasis	12
Brain organoids: the quest to decipher human-specific features of brain development	12
Allele-specific expression: applications in cancer and technical considerations	12
The role of the intestinal microbiota in allogeneic HCT: clinical associations and preclinical mechanisms	11
How strand exchange protein function benefits from ATP hydrolysis	11
Mechanisms of transgenerational epigenetic inheritance: lessons from animal model organisms	11
Epithelial morphogenesis in organoids	11
Predicting immunotherapy response through genomics	11
Reconsidering pathway choice: a sequential model of mammalian DNA double-strand break pathway decisions	11
4D epigenomics: deciphering the coupling between genome folding and epigenomic regulation with biophysical modeling	11
Lessons from single cell sequencing in CNS cell specification and function	11
Use of mouse models to investigate the contributions of CNVs associated with schizophrenia and autism to disease mechanisms	11
Regional patterning and regulation of melanin pigmentation in insects	11
Long overdue: including adults with brain disorders in precision health initiatives	11
Copy number variants in neurexin genes: phenotypes and mechanisms	11
Dysregulated translational control in brain disorders: from genes to behavior	11
The history behind the mosaic of the Americas	11
From biomechanics to mechanobiology: Xenopus provides direct access to the physical principles that shape the embryo	11
Relationship between epithelial organization and morphogen interpretation	10
Contributions of 3D chromatin structure to cell-type-specific gene regulation	10
A complex gene regulatory architecture underlies the development and evolution of cuticle morphology in Drosophila	10
Crossover or non-crossover outcomes: tailored processing of homologous recombination intermediates	10
Oncogenic fusion proteins and their role in three-dimensional chromatin structure, phase separation, and cancer	10
Kidney organoid research: current status and applications	10
Broadening primate genomics: new insights into the ecology and evolution of primate gene regulation	10
Reprogramming lineage identity through cell–cell fusion	10
Cell cycle dynamics and developmental dynamics of the 3D genome: toward linking the two timescales	10
Plants are better engineers: the complexity of plant organ morphogenesis	10
The genetic landscape of cardiovascular left–right patterning defects	9
The evolution and genetics of lepidopteran egg and caterpillar coloration	9
Non-model systems in mammalian forelimb evo-devo	9
Synthetic human embryology: towards a quantitative future	9
Neural circuit reorganisation after spinal cord injury in zebrafish	9
Nucleosomes in mammalian sperm: conveying paternal epigenetic inheritance or subject to reprogramming between generations?	9
Heliconius butterflies: a window into the evolution and development of diversity	9
Mechanobiology of vertebrate gut morphogenesis	9
Metabolic regulation in pluripotent stem cells	9
Microbial experimental evolution in a massively multiplexed and high-throughput era	9
May the best wound WIHN: the hallmarks of wound-induced hair neogenesis	9
Building the genome architecture during the maternal to zygotic transition	8
Advancements in inner ear development, regeneration, and repair through otic organoids	8

Cell type innovation at the tips of the animal tree	8
Discrete roles for Rad54 and Rdh54 during homologous recombination	8
Cancer-associated chromatin variants uncover the oncogenic role of transposable elements	8
The evolutionary and ecological potential of yeast hybrids	8
Branching out: what omics can tell us about primate evolution	8
Trends and variation in vertebrate patterns as outcomes of self-organization	8
DNA helicases in homologous recombination repair	8
Evolution of short linear motifs and disordered proteins Topic: yeast as model system to study evolution	8
Insights into the control of RAD51 nucleoprotein filament dynamics from single-molecule studies	8
Evo-devo of wing colour patterns in beetles	8
Adaptive viscoelasticity of epithelial cell junctions: from models to methods	8
Archaic hominin genomics provides a window into gene expression evolution	8
Single cell genomics and developmental biology: moving beyond the generation of cell type catalogues	8
Regulatory landscape in brain development and disease	7
Copy-number variation in congenital heart disease	7
Redox-mediated regulation of low complexity domain self-association	7
Metabolic regulation of cardiac regeneration: roles of hypoxia, energy homeostasis, and mitochondrial dynamics	7
Communication between chromatin and homologous recombination	7
Pancreatic cell fate specification: insights into developmental mechanisms and their application for lineage reprogramming	7
Nucleic acid therapeutics in neurodevelopmental disease	7
In search of conserved principles of planar cell polarization	7
Understanding lncRNA–protein assemblies with imaging and single-molecule approaches	7
Evolution and molecular bases of reproductive isolation	7
Challenges and potential solutions for studying the genetic and phenotypic architecture of adaptation in microbes	7
A GC-centered view of 3D genome organization	7
Epithelial–immune crosstalk in health and disease	7
Adipocyte plasticity in tissue regeneration, repair, and disease	7
The role of tissue maturity and mechanical state in controlling cell extrusion	7
Divergent and combinatorial mechanical strategies that promote epithelial folding during morphogenesis	7
Recent developments in adipose tissue-secreted factors and their target organs	7
Epigenetic dynamics during germline development: insights from Drosophila and C. elegans	7
Making region-specific integumentary organs in birds: evolution and modifications	6
Chromatin architecture reorganization during somatic cell reprogramming	6
Biochemical properties of fission yeast homologous recombination enzymes	6
Advances in SUMO-based regulation of homologous recombination	6
Something old, something new, something borrowed, something red: the origin of ecologically relevant novelties in Hemiptera	6
Cell plasticity in regeneration in the stomach and beyond	6
Replication timing and transcriptional control: beyond cause and effect — part IV	6
Centromere drive: chromatin conflict in meiosis	6
The frontiers of sequencing in undiagnosed neurodevelopmental diseases	6
In vivo conversion of dopamine neurons in mouse models of Parkinson’s disease — a future approach for regenerative therapy?	6
Cancer epitranscriptomics in a nutshell	6
Shaping inheritance: how distinct reproductive strategies influence DNA methylation memory in plants	6
Cancer regulatory variation	6
Recent progress and challenges in single-cell imaging of enhancer–promoter interaction	6
Recombination-dependent replication: new perspectives from site-specific fork barriers	6
It’s all in the combination: decoding the epigenome for cancer research and diagnostics	6
Methods for detecting introgressed archaic sequences	6
Insights into homology search from cryo-EM structures of RecA-DNA recombination intermediates	6
Somatic copy number variants in neuropsychiatric disorders	6
Functional genomics links genetic origins to pathophysiology in neurodegenerative and neuropsychiatric disease	6
Regulatory principles and mechanisms governing the onset of random X-chromosome inactivation	6
Novel orthogonal methods to uncover the complexity and diversity of nuclear architecture	6
Gene constraint and genotype–phenotype correlations in neurodevelopmental disorders	6
Regeneration of the pancreas: proliferation and cellular conversion of surviving cells	6
Recent insights into the evolution of mutation rates in yeast	6
Correlation between protein abundance and sequence conservation: what do recent experiments say?	6
Architecture of RNA–RNA interactions	6
Regulation of mammalian totipotency: a molecular perspective from in vivo and in vitro studies	5
Advancing global equity in cancer genomics – challenges and opportunities in Sub-Saharan Africa	5
Control of structure-specific endonucleases during homologous recombination in eukaryotes	5
The importance of including ethnically diverse populations in studies of quantitative trait evolution	5
A finger on the pulse of regeneration: insights into the cellular mechanisms of adult digit tip regeneration	5
Intestinal epithelial organoids: regeneration and maintenance of the intestinal epithelium	5
Diversification of the vertebrate limb: sequencing the events	5
Songbird germline-restricted chromosome as a potential arena of genetic conflicts	5
Harnessing epigenetics to study human evolution	5
Towards a CRISPeR understanding of homologous recombination with high-throughput functional genomics	5
Epigenetic memory in reprogramming	5
Perspectives on somatic reprogramming: spotlighting epigenetic regulation and cellular heterogeneity	5
RNA interference therapeutics for cardiac regeneration	5