Current Opinion in Genetics & Development

Article	Citations
Editorial Board	70
Editorial Board	69
Editorial overview: Conflicts, conflicts everywhere	55
Editorial Board	55
Epithelial–immune crosstalk in health and disease	49
R-loops in neurodegeneration	48
Tile by tile: capturing the evolutionary mosaic of human conditions	40
Adipose tissue endothelial cells: insights into their heterogeneity and functional diversity	38
Evolution and ecology of commensal gut protists: recent advances	35
Integrative approaches to study enhancer–promoter communication	35
The X chromosome in C. elegans sex determination and dosage compensation	33
Convergence and divergence of molecular phenotypes in iPSC-derived models of 16p11.2 and 22q11.2 reciprocal copy number variants	32
Loops, crosstalk, and compartmentalization: it takes many layers to regulate DNA methylation	31
Why is measuring and predicting fitness under genomic conflict so hard?	30
A critical role for X-chromosome architecture in mammalian X-chromosome dosage compensation	30
Therapeutic strategies to target the epitranscriptomic machinery	29
Editorial Board	29
Genetic clues to reprogramming power and formation of mouse oocyte	28
In vitro models of pre- and post-gastrulation embryonic development	28
Mitochondrial metabolism and the continuing search for ultimate regulators of developmental rate	27
High-throughput approaches to functional characterization of genetic variation in yeast	27
Control of cell fate upon transcription factor–driven cardiac reprogramming	27
Toward the dissection of hematopoietic stem cell fates and their determinants	27
Exploring the origin of the development: totipotent stem cells	26
Interplay between N-adenosine RNA methylation and mRNA splicing	25

NAT10 and cytidine acetylation in mRNA: intersecting paths in development and disease	25
Single-cell genomic profiling to study regeneration	25
Cell–cell interactions between transplanted retinal organoid cells and recipient tissues	24
Structural variation in humans and our primate kin in the era of telomere-to-telomere genomes and pangenomics	23
Recent advances in the neurogenomics of autism spectrum disorder	23
Using human pluripotent stem cells to dissect trophoblast development	23
Adipose tissue-derived lipokines in metabolism	23
If you please, draw me a neuron — linking evolutionary tinkering with human neuron evolution	23
Molecular genetics of pulmonary hypertension in children	22
Dynamic microenvironments shape nuclear organization and gene expression	22
Transposon waves at the water-to-land transition	22
Editorial Board	22
Timers, variability, and body-wide coordination: C. elegans as a model system for whole-animal developmental timing	22
Emerging oligo-based imaging methods to study chromatin organization in cells and tissue	21
Stem-cell-based human and mouse embryo models	21
Better together: how cooperativity influences transcriptional bursting	20
Genetic disruption of nonsense-mediated mRNA decay in neurodevelopmental disorders	20
Behavioral evolution by diverging cell type composition	19
Nucleosomes in mammalian sperm: conveying paternal epigenetic inheritance or subject to reprogramming between generations?	19
Genome instability in mammalian embryos implications for genome editing, development, and evolution	19
Editorial overview: Drivers, droplets, and deeds of nuclear genome organization	19
The Yin and Yang of replicative aging and rejuvenation	18
Enhancers on the edge — how the nuclear envelope controls gene regulatory elements	18
Human 8-cell embryo-like cells from pluripotent stem cells	18
Recipes and ingredients for deep learning models of 3D genome folding	17
Nuclear remodeling during cell fate transitions	17
Modifying gastruloids to dissect mechanisms of tissue-specific induction	17
Linking phenotype to genotype using comprehensive genomic comparisons	17
Chromosome organization by Structural Maintenance of Chromosomes complexes in C. elegans	17
A haystack in the needle: packaging sperm DNA in insects	17
Editorial Board	17
Intestinal epithelial organoids: regeneration and maintenance of the intestinal epithelium	17
Editorial overview: Multiscale regulation of genome folding in space, time, and across the tree of life	17
Multi-organelle-mediated mRNA localization in neurons and links to disease	17
What are tethering elements?	16
Meiotic drive of noncentromeric loci in mammalian meiosis II eggs	16
Editorial Board	16
Maternal genetic factors in the development of congenital heart defects	16
Shaping inheritance: how distinct reproductive strategies influence DNA methylation memory in plants	16
Editorial overview: Epigenetic inheritance: A shortcut to environmental adaptation?	16
Evolution of 3D chromatin organization at different scales	16
Cell identity conversion in liver regeneration after injury	16
Epigenetic priming in the male germline	16
Editorial overview: Peering into our history through a genetic lens: How advances in genetics are changing our understanding of human evolution	16
Biological roles of nonsense-mediated RNA decay: insights from the nervous system	16
Approaches to probe and perturb long noncoding RNA functions in diseases	16
Deciphering microglia phenotypes in health and disease	16
Advances in skeletal genomics research across tissues and cells	15
Editorial Board	15
Rewiring cancer: 3D genome determinants of cancer hallmarks	15

Cancer-associated chromatin variants uncover the oncogenic role of transposable elements	15
Transposable elements in early human embryo development and embryo models	15
Editorial overview: Regaining architecture and cell cross-talk upon regeneration	15
Editorial overview: Epitranscriptomics: Exploring a new frontier in health and disease	15
Songbird germline-restricted chromosome as a potential arena of genetic conflicts	15
Amending the injured heart by in vivo reprogramming	15
Mix-and-match between transposable elements and zinc finger proteins fuels genic and regulatory innovation	15
Inheritance of epigenetic transcriptional memory	15
Decoding schizophrenia through postmortem human brain transcriptomics	14
Cellular plasticity in the neural crest and cancer	14
Adipose tissue lipid metabolism: lipolysis	14
Recent developments in adipose tissue-secreted factors and their target organs	14
Alterations in transcriptional networks in cancer: the role of noncoding somatic driver mutations	14
A new era of understanding in vivo metabolic flux in thermogenic adipocytes	14
Correlation between protein abundance and sequence conservation: what do recent experiments say?	14
Cooperativity between regulatory elements acts as a modulator of enhancer function	14
Toward a comprehensive view of gene architecture during transcription	13
Evolution and molecular bases of reproductive isolation	13
Editorial Board	13
Brain organoids: the quest to decipher human-specific features of brain development	13
Challenges and potential solutions for studying the genetic and phenotypic architecture of adaptation in microbes	13
Genome folding dynamics during the M-to-G1-phase transition	13
Principles of genome activation in the early embryo	13
Editorial overview: The genome in space–time	13
The stem cell zoo for comparative studies of developmental tempo	13
Evolutionary genetics meets ecological immunology: insights into the evolution of immune systems	13
Microbial experimental evolution in a massively multiplexed and high-throughput era	13
Oncogenic fusion proteins and their role in three-dimensional chromatin structure, phase separation, and cancer	12
Exploring conditional gene essentiality through systems genetics approaches in yeast	12
Phase separation and inheritance of repressive chromatin domains	12
Alternative splicing in addiction	12
Proliferation and dissemination of killer meiotic drive loci	12
Evolution of comparative transcriptomics: biological scales, phylogenetic spans, and modeling frameworks	12
The role of loop extrusion in enhancer-mediated gene activation	12
Deep learning for psychiatric genomics: from tools to applications	12
Bridging spatial and temporal scales of developmental gene regulation	12
3D chromosomal architecture in germinal center B cells and its alterations in lymphomagenesis	12
Topical section: embryonic models (2023) for Current Opinion in Genetics & Development	12
Epistasis and evolutionary dependencies in human cancers	12
In vitro models of human hypoblast and mouse primitive endoderm	12
Chromosome organization in 4D: insights from C. elegans development	12
Reconstitution of reproductive organ system that produces functional oocytes	12
Editorial Overview: Developmental mechanisms patterning and evolution (2025)	12
The genetic landscape of cardiovascular left–right patterning defects	11
Editorial Board	11
Editorial Board	11
Cellular diversity and developmental hierarchy in the planarian nervous system	11
Paternal genome elimination: patterns and mechanisms of drive and silencing	11
Recent advances in stem cell-based blastocyst models	11
Prospects for precision genetic medicine in congenital heart disease	11
Polycomb complexes in MLL–AF9-related leukemias	11
When 3D genome changes cause disease: the impact of structural variations in congenital disease and cancer	11
Timing mechanisms: insights from comparative neural differentiation systems	10
Principles of long-range gene regulation	10
Spliceosome complex and neurodevelopmental disorders	10
Hijacked enhancer–promoter and silencer–promoter loops in cancer	10
R-loop homeostasis in genome dynamics, gene expression and development	10
The metabolic baton: conducting the dance of N6-methyladenosine writing and erasing	10
Progress in understanding the biological basis of polygenic disorders	10
Can we stop one heart from breaking: triumphs and challenges in cardiac reprogramming	10
The power of proximity: mechanisms and biological roles of transvection	10
Transposon persistence and control in germ cells	10
Ex situ-armus: experimental models for combating respiratory dysfunction	9
Decoding N6-methyladenosine’s dynamic role in stem cell fate and early embryo development: insights into RNA–chromatin interactions	9
Nonequilibrium polymer models for chromatin	9
Clinical Perspectives in Epitranscriptomics	9
To splice or not to splice: pseudoexons in neurological disease and opportunities for intervention	9
Quantitative mapping of the mammalian epitranscriptome	9
Jack of all trades versus master of one: how generalist versus specialist strategies of transposable elements relate to their horizontal transfer between lineages	9
Unlocking regeneration: how partial reprogramming resembles tissue healing	9
Editorial Board	9
Recent insights into the evolution of mutation rates in yeast	8
Pluripotent stem cell–derived mesenchymal stem cells for therapeutic applications, developmental study, and cancer research	8
Do sex-linked male meiotic drivers contribute to intrinsic hybrid incompatibilities? Recent empirical studies from flies and rodents	8
Recent insights into the in vitro culture systems for mammalian embryos	8
Epigenetic dynamics during germline development: insights from Drosophila and C. elegans	8
Experimental evolution of drug resistance in human fungal pathogens	8
Female meiotic drive in plants: mechanisms and dynamics	8
Overcoming muscle stem cell aging	8
Epistatic drift in protein evolution	8

Linking mitochondria metabolism, developmental timing, and human brain evolution	8
Interplay of transposable elements and ageing: epigenetic regulation and potential epitranscriptomic influence	8
Mitochondrial curation for the next generation	8
Temporal patterning of the vertebrate developing neural tube	8
Chromosomal instability as a source of genomic plasticity	8
Pediatric CNS cancer genomics and immunogenomics	8
The ribonucleoprotein network of the nucleus: a historical perspective	8
Circuit integration by transplanted human neurons	8
Mechanisms of regulatory evolution in yeast	8
Vascular and immune interactions in islets transplantation and 3D islet models	8
Evolutionary neurogenomics at single-cell resolution	8
Xenotransplantation — a shortcut to construct tissue complexity in organoids	8
Modification of the RNA methylome in neurodevelopmental disorders	8
The role of cohesin and DNA loop extrusion in the generation of single neuron identity	8
Editorial Board	8
Corneal regeneration: insights in epithelial stem cell heterogeneity and dynamics	8
Editorial overview: 3Rs update: a new era in cellular identity and therapeutic plasticity	8
Adipocyte plasticity in tissue regeneration, repair, and disease	7
Deciphering the role of structural variation in human evolution: a functional perspective	7
New methodological approaches and insights gained toward understanding the evolved human skeleton	7
Advancements in inner ear development, regeneration, and repair through otic organoids	7
Factors that determine cell type–specific CTCF binding in health and disease	7
Insights into multilevel spatial regulation within the root stem cell niche	7
Network models of chromatin structure	7
Editorial overview: Early embryonic development models: back to the beginning	7
Engineering immune organoids to regenerate host immune system	7
Extending the spectrum in aortopathy: stenosis to aneurysm	7
Early central nervous system development and neuron regeneration	7
Transgenerational epigenetic control of constitutive heterochromatin, transposons, and centromeres	7
Block copolymer concepts of how transcription organizes the stem cell genome	7
Finding the genetic basis of adaptation: reducing complexity to improve trait mapping	7
A lifelong duty: how Xist maintains the inactive X chromosome	7
Spatial orchestration of the genome: topological reorganisation during X-chromosome inactivation	7
When and why are mitochondria paternally inherited?	7
Therapeutic index of targeting select chromatin complexes in human cancer patients	7
The ever-growing world of gastruloids: autogenous models of mammalian embryogenesis	7
NOVA1/2 genes and alternative splicing in neurodevelopment	7
A new era in neuromuscular junction research: current advances in self-organized and assembled in vitro models	7
Narrative engineering of the liver	7
Concepts, mechanisms and implications of long-term epigenetic inheritance	7
Revitalizing psychopharmacology in the GWAS era: the potential of barcoded screening in drug discovery	6
Rethinking chromatin accessibility: from compaction to dynamic interactions	6
Editorial Board	6
Human blastoid as an in vitro model of human blastocysts	6
Recent advances in RNA-based therapeutics for neurodevelopmental disorders	6
Somatic mutation burden in relation to aging and functional life span: implications for cellular reprogramming and rejuvenation	6
Safeguarding the epigenome through the cell cycle: a multitasking game	6
Decoding the role of tRNA modifications in cancer progression	6
Editorial overview: New insights into epithelial dynamics: From tissue homeostasis to morphogenesis	6
Genomic snowflakes: how the uniqueness of DNA folding allows us to smell the chemical universe	6
Plasticity of muscle stem cells in homeostasis and aging	6
Molecular mechanisms of the specialization of human synapses in the neocortex	6
Human trophoblast stem cell-state acquisition from pluripotent stem cells and somatic cells	6
Editorial overview: Fat tissue in focus: Assembled deeply insightful perspectives on state-of-the-art explorations	6
How our brains are built: emerging approaches to understand human-specific features	6