OOIR: Observatory of International Research

Papers

(The H4-Index of Current Opinion in Structural Biology is 46. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Simultaneous codon usage, the origin of the proteome, and the emergence of de-novo proteins	238
Editorial overview: Artificial intelligence (AI) methodologies in structural biology	152
AI-based methods for biomolecular structure modeling for Cryo-EM	127
Protein binding and folding through an evolutionary lens	121
In-cell NMR: From target structure and dynamics to drug screening	120
Single-point mutations in disordered proteins: Linking sequence, ensemble, and function	115
Protein language models for predicting drug–target interactions: Novel approaches, emerging methods, and future directions	109
Extending the reach of single-particle cryoEM	107
Foundation models of protein sequences: A brief overview	107
Apprehensions and emerging solutions in ML-based protein structure prediction	98
Artificial intelligence-driven antimicrobial peptide discovery	97
Pump-like channelrhodopsins: Not just bridging the gap between ion pumps and ion channels	96
Editorial Board	86
Editorial overview: Folding and Binding (2024)	83
Regulation of tau by peptidyl-prolyl isomerases	76
Structural biology and inhibition of the Mtb cell wall glycoconjugates biosynthesis on the membrane	74
Editorial Board	71
HATs meet structural biology	70
Editorial Board	67
Editorial Board	67
3D genome organization and beyond!	66
Organization of transcription and 3D genome as revealed by live-cell imaging	65
Editorial Board	65
Single-cell mapping of cell-type specific chromatin architecture in the central nervous system	64
Advancing biomolecular simulation through exascale HPC, AI and quantum computing	63

Molecular models of bidirectional promoter regulation	61
Glycosylation as a key parameter in the design of nucleic acid vaccines	61
From disorder comes function: Regulation of small GTPase function by intrinsically disordered lipidated membrane anchor	59
The confluence of machine learning and multiscale simulations	58
Structural determinants of regulated proteolysis in pathogenic bacteria by ClpP and the proteasome	57
Solving the structural puzzle of bacterial glycome	57
Visualizing everything, everywhere, all at once: Cryo-EM and the new field of structureomics	57
RNA helicases are hubs that orchestrate exosome-dependent 3′–5′ decay	57
The role of local versus nonlocal physicochemical restraints in determining protein native structure	56
Mechanistic similarities in recognition of histone tails and DNA by epigenetic readers	54
Structural basis for DNA sequence recognition by pioneer factors in nucleosomes	54
Computer-aided drug design, quantum-mechanical methods for biological problems	52
Computational strategies for protein conformational ensemble detection	52
Multiscale kinetic analysis of proteins	51
Combining crystallography with quantum mechanics	51
How much can physics do for protein design?	50
Serial synchrotron and XFEL crystallography for studies of metalloprotein catalysis	50
Reweighting methods for elucidation of conformation ensembles of proteins	49
Revealing bacterial cell biology using cryo-electron tomography	48
Mechanistic insights into fungal mitochondrial outer membrane protein biogenesis	47
Molecular tools for probing the microbiome	46
Mutational fitness landscape and drug resistance	46
Access and utilization of long chain fatty acyl-CoA by zDHHC protein acyltransferases	46
Recent progress in membrane protein dynamics revealed by X-ray free electron lasers: Molecular movies of microbial rhodopsins	46